CN103687876A - 特异性针对β-淀粉样蛋白x-37的单克隆抗体及其用途 - Google Patents

特异性针对β-淀粉样蛋白x-37的单克隆抗体及其用途 Download PDF

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Publication number
CN103687876A
CN103687876A CN201280035194.8A CN201280035194A CN103687876A CN 103687876 A CN103687876 A CN 103687876A CN 201280035194 A CN201280035194 A CN 201280035194A CN 103687876 A CN103687876 A CN 103687876A
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China
Prior art keywords
antibody
peptide
beta
sample
amyloid
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CN201280035194.8A
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English (en)
Chinese (zh)
Inventor
M.H.梅肯
M.博格斯
M.M.P.P.范德米伦
B.J.J.范布罗伊克
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Janssen Pharmaceutica NV
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Janssen Pharmaceutica NV
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/577—Immunoassay; Biospecific binding assay; Materials therefor involving monoclonal antibodies binding reaction mechanisms characterised by the use of monoclonal antibodies; monoclonal antibodies per se are classified with their corresponding antigens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN201280035194.8A 2011-07-15 2012-07-06 特异性针对β-淀粉样蛋白x-37的单克隆抗体及其用途 Pending CN103687876A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11174224 2011-07-15
EP11174224.3 2011-07-15
PCT/EP2012/063213 WO2013010812A1 (en) 2011-07-15 2012-07-06 Monoclonal antibodies specific for beta-amyloid x-37 and uses thereof

Publications (1)

Publication Number Publication Date
CN103687876A true CN103687876A (zh) 2014-03-26

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CN201280035194.8A Pending CN103687876A (zh) 2011-07-15 2012-07-06 特异性针对β-淀粉样蛋白x-37的单克隆抗体及其用途

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Country Link
US (1) US8911731B2 (enExample)
EP (1) EP2731968A1 (enExample)
JP (1) JP2014520825A (enExample)
CN (1) CN103687876A (enExample)
AU (1) AU2012286021A1 (enExample)
CA (1) CA2841093A1 (enExample)
EA (1) EA201490286A1 (enExample)
WO (1) WO2013010812A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004029629A1 (en) * 2002-09-27 2004-04-08 Janssen Pharmaceutica N.V. N-11 truncated amyloid-beta nomoclonal antibodies, compositions, methods and uses
CN114478762B (zh) * 2022-02-15 2024-06-04 武汉天德生物科技有限公司 一种β-淀粉样多肽1-42单克隆抗体、ELISA试剂盒及其应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101124247A (zh) * 2004-07-30 2008-02-13 礼纳特神经系统科学公司 针对淀粉质-beta肽的抗体以及使用它的方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8173127B2 (en) * 1997-04-09 2012-05-08 Intellect Neurosciences, Inc. Specific antibodies to amyloid beta peptide, pharmaceutical compositions and methods of use thereof
UY29504A1 (es) * 2005-04-29 2006-10-31 Rinat Neuroscience Corp Anticuerpos dirigidos contra el péptido amiloide beta y métodos que utilizan los mismos.
CN101223185A (zh) * 2005-05-17 2008-07-16 萨托里医药公司 用于治疗神经变性障碍的化合物
EA021047B1 (ru) 2009-07-15 2015-03-31 Янссен Фармасьютикалз, Инк. Замещенные производные триазола и имидазола в качестве модуляторов гамма-секретазы

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101124247A (zh) * 2004-07-30 2008-02-13 礼纳特神经系统科学公司 针对淀粉质-beta肽的抗体以及使用它的方法

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
HOGLUND K ET AL: "Prediction of Alzheimer"s disease using a cerebropinal fluid pattern of C-terminally truncated beta-amyloid peptides", 《NEURODEGENERATIVE DISEASES》 *
MOHAMMED EL MOUEDDEN ET AL: "Development of a specific ELISA for the quantitative study of amino-terminally truncated beta-amyloid peptides", 《JOURNAL OF NEUROSCIENCE METHODS》 *

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Publication number Publication date
CA2841093A1 (en) 2013-01-24
US20140154715A1 (en) 2014-06-05
EA201490286A1 (ru) 2014-04-30
JP2014520825A (ja) 2014-08-25
US8911731B2 (en) 2014-12-16
AU2012286021A1 (en) 2014-01-16
EP2731968A1 (en) 2014-05-21
WO2013010812A1 (en) 2013-01-24

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Application publication date: 20140326