CN103655728A - Long-acting Qizhen immunity-enhancing granule pill - Google Patents
Long-acting Qizhen immunity-enhancing granule pill Download PDFInfo
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- CN103655728A CN103655728A CN201310696603.5A CN201310696603A CN103655728A CN 103655728 A CN103655728 A CN 103655728A CN 201310696603 A CN201310696603 A CN 201310696603A CN 103655728 A CN103655728 A CN 103655728A
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- stilbene
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Abstract
The invention discloses a long-acting Qizhen immunity-enhancing granule pill. The pill comprises a base pill (1) serving as a core, a medicine layer (2), a coating layer (3) and a color coating layer (4), wherein the medicine layer (2) is formed by mixing an Qizhen immunity-enhancing granules, monostearin, hydroxypropyl methyl cellulose and acrylic resin, the base pill (1) is covered with the medicine layer (2), and the medicine layer (2) is covered with the coating layer (3) and the color coating layer (4) from inside to outside sequentially. According to the pill, the problems of the short half-life period of Qizhen immunity-enhancing granules and numerous dosage times are solved, and the defects in the prior art are overcome.
Description
Technical field
The present invention relates to loyal increasing of a kind of stilbene and exempt from long-acting granular pill.
Background technology
By traditional method, prepare that long-acting stilbene is loyal increases that to exempt from granule cost too high, main cause is the loyal characteristic of exempting from granule itself that increases of stilbene.The loyal increasing of stilbene is exempted from granule and is made by the Radix Astragali, Herba Epimedii, the above three taste Chinese medicines of Fructus Ligustri Lucidi.This product granulation can overcome the oral difficulty of Chinese medicine, and drug effect is good, is applicable to extensive administration.
Summary of the invention
The object of this invention is to provide loyal increasing of a kind of stilbene and exempt from long-acting granular pill, the invention solves loyal increasing of stilbene and exempt from the problem that the granule half-life is short, administration number of times is many, made up the deficiencies in the prior art.
The technical problem that will solve required for the present invention, can be achieved through the following technical solutions:
The loyal increasing of a kind of stilbene exempted from long-acting granular pill, it is characterized in that: be followed successively by from inside to outside: as the base ball of core, and loyal increasing of stilbene exempted from the medicine layer that granule, monoglyceride, hydroxypropyl emthylcellulose (HPMC) and acrylic resin mix, coatings and color clothing layer.
Further, described base ball adopts starch to make spherical or olive shape structure.
Further, according to ratio of weight and number meter, the ratio of exempting from granule, monoglyceride, hydroxypropyl emthylcellulose and acrylic resin by the loyal increasing of stilbene in described medicine layer is that 1 ~ 10:1 ~ 10:1 ~ 10:1 ~ 10 are coated on outside base ball, makes spherical or olive shape structure.
Further, the loyal increasing of described stilbene is exempted from granule and is made chondritic by the Radix Astragali, Herba Epimedii, Fructus Ligustri Lucidi, and according to ratio of weight and number meter, the Radix Astragali, Herba Epimedii, Fructus Ligustri Lucidi are 1 ~ 10:1 ~ 10:1 ~ 10.
Further, according to ratio of weight and number meter, described coatings is by polyacrylic resin 50 ~ 60, Pulvis Talci 8 ~ 10, and triethyl citrate 1 ~ 2, water 30 ~ 40 is coated on outside medicine layer, makes spherical or olive shape structure.
Further, described color clothing layer adopts food coloring to be coated on outside coatings, makes spherical or olive shape structure.
Hydroxypropyl emthylcellulose (Hydroxypropyl Methyl Cellulose is called for short HPMC or MHPC)
Pharmacological action: the loyal increasing of a kind of stilbene of the present invention exempted from long-acting granular pill, and the ability of penetration cell wall is strong, can anti-bacteria cell membrane synthetic, make antibacterial become spheroid and dissolvings of breaking rapidly, thus to the bactericidal action of various bacteria compared with rapidly and by force.
Indication: for poultry escherichia coli, Salmonella, streptococcus, the caused enteritis such as Bacillus proteus and pasteurellosis bacillus, diarrhoea, salpingitis, oophoritis, the mould unrest of fowl, injury flu, bronchitis, pneumonia, the diseases such as mycoplasma infection.
Consumption usage:
Mixed drink, every 50 grams of this product are converted 200L water and are drunk for poultry.
Mixed feeding, the loyal increasing of every 100g stilbene exempted from granule.
Calomelas: be general processing technique, product for animals is all used Calomelas to be dissolved in water, drinks to beast.
Heavy powder: be through compacting, granulate, mixed powder, the particle size distribution that the physical process such as sieve obtains reaches necessarily required product, and heavy powder can be directly encapsulated.
Beneficial effect of the present invention:
The loyal increasing of a kind of stilbene of the present invention exempted from long-acting granular pill, granule is exempted from the loyal increasing of employing stilbene and blocker mixing granulation is realized slow release object, and it is 12 hours that the granule half-life is exempted from the loyal increasing of stilbene of the present invention, and administration number of times is 12 hours/time, greatly save production cost, improved economic benefit.
Accompanying drawing explanation
Fig. 1 is structural representation of the present invention.
Reference numeral:
The 1st, base ball, the 2nd, medicine layer, the 3rd, coatings, the 4th, color clothing layer.
The specific embodiment
Below in conjunction with specific embodiment, the present invention is done to progressive explanation.Should be understood that following examples are only for the present invention is described but not for limiting scope of the present invention.
Embodiment 1
Fig. 1 is structural representation of the present invention, as shown in Figure 1, the loyal increasing of a kind of stilbene exempted from long-acting granular pill, be followed successively by from inside to outside: as the base ball 1 of core, and loyal increasing of stilbene exempted from the medicine layer 2 that granule, monoglyceride, hydroxypropyl emthylcellulose (HPMC) and acrylic resin mix), coatings 3 and color clothing layer 4, coated layer by layer.
Base ball 1 adopts starch to make spherical or olive shape structure.In the present embodiment, the diameter of base ball 1 is about the spherical of 0.2mm.
According to ratio of weight and number meter, the ratio of exempting from granule, monoglyceride, hydroxypropyl emthylcellulose HPMC and acrylic resin by the loyal increasing of stilbene in medicine layer 2 is that 1 ~ 10:1 ~ 10:1 ~ 10:1 ~ 10 are coated on outside base ball 1, makes spherical or olive shape structure.
The loyal increasing of stilbene is exempted from granule and is made chondritic by the Radix Astragali, Herba Epimedii, Fructus Ligustri Lucidi, and the diameter of this chondritic is 0.1 ~ 1mm.
According to ratio of weight and number meter, the Radix Astragali, Herba Epimedii, Fructus Ligustri Lucidi are 1 ~ 10:1 ~ 10:1 ~ 10.The thickness of medicine layer 2 is about 0.2mm.
According to ratio of weight and number meter, coatings 3 is by polyacrylic resin 50 ~ 60, Pulvis Talci 8 ~ 10, and triethyl citrate 1 ~ 2, water 30 ~ 40 is coated on outside medicine layer 2, makes spherical or olive shape structure.
In the present embodiment, coatings 3 is got 53g, Pulvis Talci 8g, triethyl citrate 1. 6g, water 37. 4g for polyacrylic resin can adopt especially strange L30D_55; In coatings, solids content 25. 5%, and in coatings, polymer content 15. 9%.The thickness of coatings 3 is about 0.15mm.
Color clothing layer 4 adopts food coloring to be coated on outside coatings 3, makes spherical or olive shape structure.
The supplementary material of amount of calculation is mixed after equal Uniform, and spray adds ready 5%PVP solution and makes suitable soft material.By shot-blasting machine pill-rolling, fluid bed screens 30-40 object coating of pellets, weightening finish 5% after drying.The thickness of color clothing layer 4 is about 0.06mm.
Through evidence, a kind of stilbene of the present invention is loyal to be increased and exempts from long-acting granular pill and really solved loyal increasing of stilbene and exempt from the problem that the granule half-life is short, administration number of times is many, has made up the deficiencies in the prior art.
Above the specific embodiment of the present invention is illustrated, but the present invention is as limit, only otherwise depart from aim of the present invention, the present invention can also have various variations.
Claims (6)
1. loyal increasing of stilbene exempted from long-acting granular pill, it is characterized in that: be followed successively by from inside to outside: as the base ball (1) of core, and loyal increasing of stilbene exempted from the medicine layer (2) that granule, monoglyceride, hydroxypropyl emthylcellulose and acrylic resin mix, coatings (3) and color clothing layer (4).
2. pill according to claim 1, is characterized in that: described base ball (1) adopts starch to make spherical or olive shape structure.
3. pill according to claim 1, it is characterized in that: according to ratio of weight and number meter, the ratio of exempting from granule, monoglyceride, hydroxypropyl emthylcellulose (HPMC) and acrylic resin by the loyal increasing of stilbene in described medicine layer (2) is that 1 ~ 10:1 ~ 10:1 ~ 10:1 ~ 10 are coated on outside base ball (1), makes spherical or olive shape structure.
4. pill according to claim 3, is characterized in that: the loyal increasing of described stilbene is exempted from granule and made chondritic by the Radix Astragali, Herba Epimedii, Fructus Ligustri Lucidi, and according to ratio of weight and number meter, the Radix Astragali, Herba Epimedii, Fructus Ligustri Lucidi are 1 ~ 10:1 ~ 10:1 ~ 10.
5. pill according to claim 1, is characterized in that: according to ratio of weight and number meter, described coatings (3) is by polyacrylic resin 50 ~ 60, Pulvis Talci 8 ~ 10, triethyl citrate 1 ~ 2, water 30 ~ 40 is coated on outside medicine layer (2), makes spherical or olive shape structure.
6. pill according to claim 1, is characterized in that: described color clothing layer (4) adopts food coloring to be coated on outside coatings (3), makes spherical or olive shape structure.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310696603.5A CN103655728A (en) | 2013-12-18 | 2013-12-18 | Long-acting Qizhen immunity-enhancing granule pill |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310696603.5A CN103655728A (en) | 2013-12-18 | 2013-12-18 | Long-acting Qizhen immunity-enhancing granule pill |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103655728A true CN103655728A (en) | 2014-03-26 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310696603.5A Pending CN103655728A (en) | 2013-12-18 | 2013-12-18 | Long-acting Qizhen immunity-enhancing granule pill |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106668180A (en) * | 2016-12-26 | 2017-05-17 | 李劲松 | Drug capable of preventing pigs from being attacked by diseases during porcine stress |
| CN114129588A (en) * | 2021-10-28 | 2022-03-04 | 湖南农业大学 | Antibacterial composition containing astragalus extract and application thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101647852A (en) * | 2009-08-28 | 2010-02-17 | 缪雪荣 | Veterinary medicine for enhancing immunologic function |
| CN201426857Y (en) * | 2009-07-13 | 2010-03-24 | 上海恒丰强动物药业有限公司 | Amoxicillin long-acting granular pill |
| KR20120097268A (en) * | 2011-02-24 | 2012-09-03 | 대구한의대학교산학협력단 | Composition comprising the combined extract of astragalus membranaceus bunge and plantago asiatica for preventing and treating obesity |
-
2013
- 2013-12-18 CN CN201310696603.5A patent/CN103655728A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN201426857Y (en) * | 2009-07-13 | 2010-03-24 | 上海恒丰强动物药业有限公司 | Amoxicillin long-acting granular pill |
| CN101647852A (en) * | 2009-08-28 | 2010-02-17 | 缪雪荣 | Veterinary medicine for enhancing immunologic function |
| KR20120097268A (en) * | 2011-02-24 | 2012-09-03 | 대구한의대학교산학협력단 | Composition comprising the combined extract of astragalus membranaceus bunge and plantago asiatica for preventing and treating obesity |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106668180A (en) * | 2016-12-26 | 2017-05-17 | 李劲松 | Drug capable of preventing pigs from being attacked by diseases during porcine stress |
| CN114129588A (en) * | 2021-10-28 | 2022-03-04 | 湖南农业大学 | Antibacterial composition containing astragalus extract and application thereof |
| CN114129588B (en) * | 2021-10-28 | 2024-01-23 | 湖南农业大学 | Antibacterial composition containing astragalus extract and application thereof |
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Application publication date: 20140326 |