CN203089942U - Tiamulin long-acting particle pill - Google Patents
Tiamulin long-acting particle pill Download PDFInfo
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- CN203089942U CN203089942U CN 201220703993 CN201220703993U CN203089942U CN 203089942 U CN203089942 U CN 203089942U CN 201220703993 CN201220703993 CN 201220703993 CN 201220703993 U CN201220703993 U CN 201220703993U CN 203089942 U CN203089942 U CN 203089942U
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Abstract
The utility model aims at disclosing a tiamulin long-acting particle pill. The tiamulin long-acting particle pill comprises a basic pill which is used as a core, a drug layer which is formed by tiamulin, monostearin, HPMC (Hydroxy Propyl Methyl Cellulose) and acrylic resin via mixing, a polymer controlled-release coating layer and a color coating layer, wherein the drug layer is coated on the basic pill; and the polymer controlled-release coating layer and the color coating layer are sequentially coated at the outer side of the drug layer. According to the tiamulin long-acting particle pill, the problem that the tiamulin in the prior art is short in half-life period and needs long-time dosing is effectively solved; and the aim of drug controlled release is realized through mixing tiamulin and a retarder for granulation, so that the half-life period of the drug is greatly prolonged and the curative effect of the drug is improved.
Description
Technical field
This utility model relates to a kind of structure of granule pill, particularly a kind of taimulin long-acting granular pill.
Background technology
It is too high to prepare long-acting taimulin pill cost by traditional method, mainly is the character because of taimulin itself, and its character of taimulin (Tiamulin) is white or off-white color crystalline powder, easily molten in methanol or ethanol, water-soluble, molten in the acetone part omitted, be dissolved in ethane hardly.Taimulin is after obtaining pleuromutilin by higher fungus basidiomycetes pleurotus Pleurotus mutilus fermentation, to obtain the hydrogenation fumarate through chemosynthesis again, is the special-purpose antibiotic of a kind of di-terpene class poultry.Nineteen fifty-one is proposed first by Australian Kavangh, begins broad research the sixties, is one of the world's ten big antibiotic for animals.This product antimicrobial spectrum is to similar to macrolide antibiotics, main resisting gram-positive bacteria, staphylococcus aureus, streptococcus, mycoplasma, actinobacillus pleuropneumoniae, pig treponema dysentery etc. there is stronger inhibitory action, strong and the Macrolide to the effect of mycoplasma is a little less than gram negative bacteria especially intestinal effect.And present taimulin has the half-life short, needs the problem of long-time administration, generally takes successive administration 5-10 days.
Therefore, needed a kind of taimulin long-acting granular pill especially, to address the above problem.
The utility model content
The purpose of this utility model provides a kind of taimulin long-acting granular pill, short with the taimulin half-life in the solution prior art, as to need long-time administration problem.
To achieve these goals, the technical solution of the utility model is as follows:
A kind of taimulin long-acting granular pill, it is characterized in that, medicine layer, polymer sustained release coating layer and color clothing layer that it comprises basic ball as core, is formed by taimulin, monoglyceride, HPMC and interior olefin(e) acid mixed with resin, described medicine layer is coated on the basic ball, and the outside of described medicine layer is coated with polymer sustained release coating layer and color clothing layer successively.
In an embodiment of the present utility model, the diameter of described basic ball is about 0.2mm.
In an embodiment of the present utility model, the thickness of described medicine layer is about 0.2mm.
In an embodiment of the present utility model, the thickness of described polymer sustained release coating layer is about 0.15mm.
In an embodiment of the present utility model, the thickness of described color clothing layer is about 0.06mm.
Taimulin long-acting granular pill of the present utility model, its pharmacological action is: taimulin is a kind of former ribosome inhibitor, by with ribosomal 50S subunit permanent bond, synthesizing of blocking-up bacterial peptide chain, thereby suppress the synthetic of bacterioprotein and key enzyme, stop the growth and breeding of antibacterial.Antibacterial is difficult for producing drug resistance to fumaric acid tiamulin, also is difficult for producing cross resistance with other antibiotic.Fumaric acid tiamulin belongs to bacteriostatic antibiotic, but high concentration also has bactericidal action to sensitive organism, and multiple gram-positive cocci (comprising most of staphylococcuses and streptococcus) and multiple mycoplasma are had good antibacterial activity with some spirillum.But the activity to some gram negative bacteria is very low, and haemophilus and some escherichia coli and klebsiella bacterial strain are had good antibacterial activity.Indication: be mainly used in the control chronic respiratory disease, mycoplasmal pneumonia of swine (asthma), actinomycetes property pleuropneumonia and treponema dysentery etc.Low dosage can promote growth, improves efficiency of feed utilization.The consumption usage: mix drink, per 50 gram this product are converted 200L water and are drunk for poultry, mixed feeding, and every 100g taimulin Calomelas: be general processing technique, product for animals all uses Calomelas water-soluble, drinks to beast.Heavy powder: be through compacting, granulate mixes powder, and the particle size distribution that physical process such as sieve obtains reaches necessarily required product, and heavy powder can be directly encapsulated.
Taimulin long-acting granular pill of the present utility model, efficiently solve the problem of taimulin half-life weak point in the prior art, the long-time administration of needs, realize the purpose of medicament slow release by adopting taimulin and blocker mixing granulation, improve the half-life of medicine greatly, improved the curative effect of medicine.
Characteristics of the present utility model can be consulted the detailed description of the graphic and following better embodiment of this case and be obtained to be well understood to.
Description of drawings
Fig. 1 is the structural representation of a kind of taimulin long-acting granular of this utility model pill;
Wherein, l is basic ball, the 2nd, and medicine layer, the 3rd, polymer sustained release coating layer, the 4th, color clothing layer.
The specific embodiment
For technological means, creation characteristic that this utility model is realized, reach purpose and effect is easy to understand, further set forth this utility model below in conjunction with specific embodiment.
As shown in Figure 1, taimulin long-acting granular pill of the present utility model, medicine layer 2, polymer sustained release coating layer 3 and color clothing layer 4 that it comprises basic ball 1 as core, is formed by taimulin, monoglyceride, HPMC and interior olefin(e) acid mixed with resin, described medicine layer 2 is coated on the basic ball 1, and the outside of described medicine layer 2 is coated with polymer sustained release coating layer 3 and color clothing layer 4 successively.
In this utility model, the diameter of described basic ball 1 is about 0.2mm.
In this utility model, the thickness of described medicine layer 2 is about 0.2mm.
In this utility model, the thickness of described polymer sustained release coating layer 3 is about 0.15mm.
In this utility model, the thickness of described color clothing layer 4 is about 0.06mm.
Taimulin long-acting granular pill of the present utility model, its pharmacological action is: taimulin is a kind of former ribosome inhibitor, by with ribosomal 50S subunit permanent bond, synthesizing of blocking-up bacterial peptide chain, thereby suppress the synthetic of bacterioprotein and key enzyme, stop the growth and breeding of antibacterial.Antibacterial is difficult for producing drug resistance to fumaric acid tiamulin, also is difficult for producing cross resistance with other antibiotic.Fumaric acid tiamulin belongs to bacteriostatic antibiotic, but high concentration also has bactericidal action to sensitive organism, and multiple gram-positive cocci (comprising most of staphylococcuses and streptococcus) and multiple mycoplasma are had good antibacterial activity with some spirillum.But the activity to some gram negative bacteria is very low, and haemophilus and some escherichia coli and klebsiella bacterial strain are had good antibacterial activity.Indication: be mainly used in the control chronic respiratory disease, mycoplasmal pneumonia of swine (asthma), actinomycetes property pleuropneumonia and treponema dysentery etc.Low dosage can promote growth, improves efficiency of feed utilization.The consumption usage: mix drink, per 50 gram this product are converted 200L water and are drunk for poultry, mixed feeding, and every 100g taimulin Calomelas: be general processing technique, product for animals all uses Calomelas water-soluble, drinks to beast.Heavy powder: be through compacting, granulate mixes powder, and the particle size distribution that physical process such as sieve obtains reaches necessarily required product, and heavy powder can be directly encapsulated.
Taimulin long-acting granular pill of the present utility model, efficiently solve the problem of taimulin half-life weak point in the prior art, the long-time administration of needs, realize the purpose of medicament slow release by adopting taimulin and blocker mixing granulation, improve the half-life of medicine greatly, improved the curative effect of medicine.
More than show and described ultimate principle of the present utility model, principal character and advantage of the present utility model.The technical staff of the industry should understand; this utility model is not restricted to the described embodiments; what describe in the foregoing description and the description is principle of the present utility model; this utility model also has various changes and modifications under the prerequisite that does not break away from this utility model spirit and scope, and these changes and improvements all fall in the claimed scope of the present utility model.The protection domain that this utility model requires is defined by appending claims and equivalent thereof.
Claims (5)
1. taimulin long-acting granular pill, it is characterized in that, it comprises basic ball, medicine layer, polymer sustained release coating layer and color clothing layer as core, and described medicine layer is coated on the basic ball, and the outside of described medicine layer is coated with polymer sustained release coating layer and color clothing layer successively.
2. profit requires 1 described taimulin long-acting granular pill, it is characterized in that the diameter of described basic ball is about 0.2mm.
3. profit requires 1 described taimulin long-acting granular pill, it is characterized in that the thickness of described medicine layer is about 0.2mm.
4. the described taimulin long-acting granular of claim 1 pill is characterized in that, the thickness of described polymer sustained release coating layer is about 0.15mm.
5. the described taimulin long-acting granular of claim 1 pill is characterized in that, the thickness of described color clothing layer is about 0.06mm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201220703993 CN203089942U (en) | 2012-12-18 | 2012-12-18 | Tiamulin long-acting particle pill |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201220703993 CN203089942U (en) | 2012-12-18 | 2012-12-18 | Tiamulin long-acting particle pill |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN203089942U true CN203089942U (en) | 2013-07-31 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201220703993 Expired - Lifetime CN203089942U (en) | 2012-12-18 | 2012-12-18 | Tiamulin long-acting particle pill |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN203089942U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103610739A (en) * | 2013-12-05 | 2014-03-05 | 江苏恒丰强生物技术有限公司 | Liquorice pellet pill |
-
2012
- 2012-12-18 CN CN 201220703993 patent/CN203089942U/en not_active Expired - Lifetime
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103610739A (en) * | 2013-12-05 | 2014-03-05 | 江苏恒丰强生物技术有限公司 | Liquorice pellet pill |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CX01 | Expiry of patent term |
Granted publication date: 20130731 |
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| CX01 | Expiry of patent term |