CN103652939B - 多种维生素c胶囊 - Google Patents
多种维生素c胶囊 Download PDFInfo
- Publication number
- CN103652939B CN103652939B CN201210315081.5A CN201210315081A CN103652939B CN 103652939 B CN103652939 B CN 103652939B CN 201210315081 A CN201210315081 A CN 201210315081A CN 103652939 B CN103652939 B CN 103652939B
- Authority
- CN
- China
- Prior art keywords
- vitamin
- capsule
- calcium
- human body
- multivitamin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 235000019154 vitamin C Nutrition 0.000 title claims abstract description 53
- 239000011718 vitamin C Substances 0.000 title claims abstract description 53
- 239000002775 capsule Substances 0.000 title claims abstract description 25
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims abstract description 87
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims abstract description 42
- 229930003268 Vitamin C Natural products 0.000 claims abstract description 42
- CWYNVVGOOAEACU-UHFFFAOYSA-N Fe2+ Chemical compound [Fe+2] CWYNVVGOOAEACU-UHFFFAOYSA-N 0.000 claims abstract description 12
- 239000011782 vitamin Substances 0.000 claims abstract description 11
- 239000002994 raw material Substances 0.000 claims abstract description 5
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 9
- 239000011734 sodium Substances 0.000 claims description 9
- 229910052708 sodium Inorganic materials 0.000 claims description 9
- 239000011692 calcium ascorbate Substances 0.000 claims description 8
- 235000010376 calcium ascorbate Nutrition 0.000 claims description 8
- 229940047036 calcium ascorbate Drugs 0.000 claims description 8
- BLORRZQTHNGFTI-ZZMNMWMASA-L calcium-L-ascorbate Chemical compound [Ca+2].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] BLORRZQTHNGFTI-ZZMNMWMASA-L 0.000 claims description 8
- WIGIZIANZCJQQY-UHFFFAOYSA-N 4-ethyl-3-methyl-N-[2-[4-[[[(4-methylcyclohexyl)amino]-oxomethyl]sulfamoyl]phenyl]ethyl]-5-oxo-2H-pyrrole-1-carboxamide Chemical compound O=C1C(CC)=C(C)CN1C(=O)NCCC1=CC=C(S(=O)(=O)NC(=O)NC2CCC(C)CC2)C=C1 WIGIZIANZCJQQY-UHFFFAOYSA-N 0.000 claims description 7
- 239000004677 Nylon Substances 0.000 claims description 4
- 229920001903 high density polyethylene Polymers 0.000 claims description 4
- 239000004700 high-density polyethylene Substances 0.000 claims description 4
- 229920001778 nylon Polymers 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 238000005516 engineering process Methods 0.000 claims description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 abstract description 15
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract description 11
- 239000011575 calcium Substances 0.000 abstract description 11
- 229910052791 calcium Inorganic materials 0.000 abstract description 11
- 238000002360 preparation method Methods 0.000 abstract description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 7
- -1 compound vitamin Chemical class 0.000 abstract description 5
- 150000003722 vitamin derivatives Chemical class 0.000 abstract description 4
- 239000013589 supplement Substances 0.000 abstract description 2
- 150000003700 vitamin C derivatives Chemical class 0.000 abstract description 2
- 229930003231 vitamin Natural products 0.000 abstract 4
- 235000013343 vitamin Nutrition 0.000 abstract 4
- 229940088594 vitamin Drugs 0.000 abstract 4
- 235000015097 nutrients Nutrition 0.000 abstract 1
- PPASLZSBLFJQEF-RXSVEWSESA-M sodium-L-ascorbate Chemical compound [Na+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RXSVEWSESA-M 0.000 abstract 1
- 230000001502 supplementing effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 description 13
- 239000000047 product Substances 0.000 description 10
- 239000003814 drug Substances 0.000 description 7
- 229910052742 iron Inorganic materials 0.000 description 7
- 238000010521 absorption reaction Methods 0.000 description 6
- 230000002354 daily effect Effects 0.000 description 6
- 230000036541 health Effects 0.000 description 6
- 235000016709 nutrition Nutrition 0.000 description 6
- 230000000694 effects Effects 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 230000035764 nutrition Effects 0.000 description 5
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 4
- 230000004060 metabolic process Effects 0.000 description 4
- FKNQFGJONOIPTF-UHFFFAOYSA-N Sodium cation Chemical compound [Na+] FKNQFGJONOIPTF-UHFFFAOYSA-N 0.000 description 3
- 230000005540 biological transmission Effects 0.000 description 3
- 229910001415 sodium ion Inorganic materials 0.000 description 3
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 2
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 2
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 229910001424 calcium ion Inorganic materials 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 229910052500 inorganic mineral Inorganic materials 0.000 description 2
- 239000011777 magnesium Substances 0.000 description 2
- 229910052749 magnesium Inorganic materials 0.000 description 2
- 229910021645 metal ion Inorganic materials 0.000 description 2
- 239000011707 mineral Substances 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 238000004806 packaging method and process Methods 0.000 description 2
- 230000035479 physiological effects, processes and functions Effects 0.000 description 2
- 239000011591 potassium Substances 0.000 description 2
- 229910052700 potassium Inorganic materials 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 238000005728 strengthening Methods 0.000 description 2
- 230000009469 supplementation Effects 0.000 description 2
- PFTAWBLQPZVEMU-DZGCQCFKSA-N (+)-catechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-DZGCQCFKSA-N 0.000 description 1
- 208000006820 Arthralgia Diseases 0.000 description 1
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- VTLYFUHAOXGGBS-UHFFFAOYSA-N Fe3+ Chemical compound [Fe+3] VTLYFUHAOXGGBS-UHFFFAOYSA-N 0.000 description 1
- 206010018276 Gingival bleeding Diseases 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 description 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 208000007502 anemia Diseases 0.000 description 1
- 230000003064 anti-oxidating effect Effects 0.000 description 1
- 230000002180 anti-stress Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- QXDMQSPYEZFLGF-UHFFFAOYSA-L calcium oxalate Chemical compound [Ca+2].[O-]C(=O)C([O-])=O QXDMQSPYEZFLGF-UHFFFAOYSA-L 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 235000015872 dietary supplement Nutrition 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 239000002389 essential drug Substances 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 230000029142 excretion Effects 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 235000013373 food additive Nutrition 0.000 description 1
- 239000002778 food additive Substances 0.000 description 1
- 230000027119 gastric acid secretion Effects 0.000 description 1
- 229930182470 glycoside Natural products 0.000 description 1
- 150000002338 glycosides Chemical class 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 1
- 230000003907 kidney function Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 210000003141 lower extremity Anatomy 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 230000027939 micturition Effects 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 230000000050 nutritive effect Effects 0.000 description 1
- 235000006408 oxalic acid Nutrition 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 150000003014 phosphoric acid esters Chemical class 0.000 description 1
- 230000019612 pigmentation Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- ZNCPFRVNHGOPAG-UHFFFAOYSA-L sodium oxalate Chemical compound [Na+].[Na+].[O-]C(=O)C([O-])=O ZNCPFRVNHGOPAG-UHFFFAOYSA-L 0.000 description 1
- 159000000000 sodium salts Chemical group 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 description 1
- 208000037816 tissue injury Diseases 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/30—Encapsulation of particles, e.g. foodstuff additives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Nutrition Science (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
本发明提供了一种多种维生素C胶囊，可用于人体日常进行营养素强化补充的多种维生素C胶囊，采用了维生素C亚铁、维生素C钙、维生素C钠、维生素C等三种以上(含三种)的维生素C及其衍生物为主要原料，经粉碎，过筛，混合的方法制得，并装入胶囊。由于多种维生素C胶囊的产品性能稳定，其内容物在水中溶解性好、人体吸收率高，pH值在7.2～7.8之间、安全性能好；能同时补充维生素C、铁、钙等，能替代目前单一或复方维生素C类口服制剂的应用，多种维生素C胶囊将成为新的维生素C类补充剂消费热点。
Description
技术领域
本发明涉及一种日常补充维生素C与矿物质的营养强化剂类产品，尤其是一种多种维生素C胶囊。
背景技术
维生素C类衍生物是国内外广泛使用的维生素C强化剂，已经逐步替代维生素C使用。但除了美国、意大利、瑞士和日本外，我国尚未有多种维生素C的制剂供人们使用；据国外有关临床报道，维生素C与其衍生物的混合物可提高人体的维生素C生理饱和水平值，提升人体内血液与细胞内维生素C的浓度与储量，有助于满足人体对维生素C的吸收利用与代谢平衡等生理需求；单一或复合维生素C类制剂是临床基本用药或日常保健营养强化剂，广泛应用于日常保健或多种疾病的预防与治疗上。由于维生素C酸性较强(4％水溶液pH值约为2.4)，日常营养补充或临床应用上面临众多胃肠道、肾功能不好等人群不宜长期使用，有促进胃酸分泌增多、尿频等不良作用；另酸性的维生素C不宜与众多药物(碱性药物或含苷类的中药)同时使用；单方或复方维生素C钠制剂，只能单一补充维生素C，不能同时增加补充人体其它必需元素；单方维生素C钙制剂的生物利用度与水溶性欠佳，可影响人体的吸收传输，代谢物为草酸钙等，长期大剂量使用可能引起结石；另目前尚无人体补充维生素C钾、维生素C磷酸脂镁与维生素C亚铁的维生素C营养强化保健产品或药品制剂在我国生产应用的报道。
随着我国全民慢病、未病防治及养生保健意识的提升，人们对补充维生素C与矿物质类产品的需求量、使用量在逐年的增大，使用时间不断延长；为了扩大维生素C类产品的使用范围，保证营养补充均衡与安全，急需开发一种pH值在7.2～7.8之间，并能同时补充人体生理必需元素铁、钙的多种维生素C胶囊，以替代单方或复方维生素C类产品在日常保健、预防与治疗疾病中的应用。
本发明的目的是提供一种产品性能稳定，其内容物在水中溶解性好、人体吸收率高，pH值介于7.2～7.8之间，安全性能好，适用人群与使用范围较广；可同时补充铁、钙等其它人体必需元素，并能替代单方或复方维生素C类口服制剂产品进行补充维生素C的多种维生素C胶囊。
多种维生素C胶囊因维生素C类衍生物原料不稳定，因此配方组成、制备要求都要有所突破，稳定性研究就要做得更为细致严谨，围绕技术难点，本发明采用了新的配方组成、制剂包装选择与酸碱度调节的应用办法，并在研制、调配、工艺上进行新的改进。
发明内容
本发明的技术方案。包括：
1、原料重量配比组成：
维生素C亚铁：87.26份
维生素C钙： 107.00份
维生素C钠： 39.00份
维生素C： 1.74份
据文献报道：维生素C能将人体内的三价铁还原为二价铁，有助于人体对铁质的吸收利用；维生素C亚铁作为临床药品、维C补充剂、补铁剂也在国外广泛使用多年；钙离子在维生素C存在的情况下更易于吸收，维生素C钙作为补钙营养强化剂、维C补充剂也在国内外的日常保健与临床应用中使用多年；人体维生素C主要通过钠离子依赖性维生素C传输通道(SVCT)进行吸收传输，在钠离子存在情况下吸收利用最佳，维生素C钠有助于人体安全、高效吸收维生素C；另在人体的金属阳离子的代谢排泄中，首先排出的是钠盐，其次才是钾、钙、镁等；在维生素C代谢中，钠离子能替代钙离子优先与草酸结合，形成水溶性草酸钠盐，降低人体因同时补充维生素C与钙时，可能形成草酸钙结石的风险；维生素C具有良好的抗氧化性，可保护制剂中各组合物的稳定性，同时具有较强的酸性可有效调节本组合物的酸碱度。
维生素C及其衍生物易受金属离子影响，过筛时宜选用尼龙筛。为了减少湿度、氧气、金属离子、温度、其它赋形剂对多种维生素C补充剂的影响，不采用制粒工艺。
装胶囊前的混合物应控制水份在1％以下，应使用水含量较低、密闭性好的空心胶囊。
制剂内容物的pH值控制在7.2～7.8之间。
2、配方依据
本发明的原料配比确定了本胶囊剂的规格为235mg/粒；相当于维生素C200mg、亚铁12mg、钙10mg。多种维生素C混合物在避光、干燥情况下稳定，但易受到光照、湿度、氧气、温度、pH值等因素影响而缓慢氧化，因此避光、防潮甚为重要。采用水含量低及密闭性好的胶囊剂，可有效防氧化、防潮湿及避免光的直接照射；采用高密度聚乙烯瓶包装能提升保持其内容物的温度恒定，并方便使用与携带，若另行内置干燥剂保证在正常使用中不易吸湿，效果更佳。在试制过程中，发现随着湿度的加大，pH值的影响也会加大，pH值控制在7.2～7.8之间，实验结果较为理想。
3、工艺流程
将维生素C亚铁、维生素C钙、维生素C钠、维生素C分别粉碎，过80目尼龙筛；将各原料置混合机中，充分混匀，装入胶囊，经高密度聚乙烯瓶包装即可。
发明的优点及积极效果
在国内，维生素C、维生素C钠、维生素C钙作为临床药品、膳食补充剂、食品添加剂、营养强化剂和抗氧化剂而广泛使用多年；在国外，维生素C亚铁作为临床药品、维C强化补充剂、补铁剂也广泛使用多年。整体组成配方中的各成分，经多年人体广泛使用在国家相关日摄入补充标准剂量以内安全、可靠；各配方组分混合后，能提升人体对其所含的各种元素的吸收、利用，形成协同增效的作用。据国外资讯报道，美国可能有相关多元维生素C类相拟产品，但具体组合配方不同，查新表明国内尚无相关制剂；多种维生素C胶囊的成功开发，将填补我国国内空白，同时由于多种维生素C胶囊的产品性能稳定，抗湿性好，能高效补充维生素C、铁、钙，pH值介于7.2～7.8之间，人体长期使用安全，能替代目前单一或复方维生素C类的口服制剂的应用，多种维生素C胶囊将成为新的维生素C补充剂消费热点。
产品的用途
维生素C、亚铁、钙补充剂。
1、有助于骨胶原的生物合成，有助于组织创伤口的愈合。
2、有助于人体氨基酸中酪氨酸和色氨酸的代谢，有助于改善色素沉着，延长肌体寿命。
3、有助于改善缺铁性贫血，促进人体对维生素C、铁、钙等的利用。
4、有助于脂肪和类脂特别是胆固醇的代谢，有助于预防心血管病。
5、有助于牙齿和骨骼的生长，防止牙床出血，防止关节痛、腰腿痛。
6、有助于增强肌体对外界环境的抗应激能力和免疫力。
7、有助于坚固结缔组织。
8、有助于胶原蛋白的合成，防止牙龈出血。
使用方法
口服，每次1粒，每日1～3粒。
具体实施方式
分别称取：维生素C亚铁872.6g、维生素C钙1070g、维生素C钠390g、维生素C17.4g。
将维生素C亚铁、维生素C钙、维生素C钠、维生素C分别粉碎，过80目尼龙筛；按等量递增法混合均匀，然后置于混合机中充分混匀20分钟，送检合格后填充胶囊，装入合格的1号胶囊，经检验合格后，装入高密度聚乙烯瓶中，包装即得。
共制成10000粒胶囊，每粒含多种维生素C235mg[约相当于200mg维生素C、12mg铁、10mg钙、4.5mg钠、8.5mg化合水]。
Claims (3)
1.一种多种维生素C胶囊，其特征在于其组成配方及重量配比如下：
2.根据权利要求1所述的多种维生素C胶囊，其特征在于生产工艺为：
将维生素C亚铁、维生素C钙、维生素C钠、维生素C分别粉碎，过80目尼龙筛；将各原料置混合机中，充分混匀，装入胶囊，经高密度聚乙烯瓶包装即可。
3.根据权利要求1所述的多种维生素C胶囊，其特征在于：多种维生素C胶囊内容物的pH值在7.2～7.8之间。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210315081.5A CN103652939B (zh) | 2012-08-30 | 2012-08-30 | 多种维生素c胶囊 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210315081.5A CN103652939B (zh) | 2012-08-30 | 2012-08-30 | 多种维生素c胶囊 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103652939A CN103652939A (zh) | 2014-03-26 |
| CN103652939B true CN103652939B (zh) | 2015-04-01 |
Family
ID=50292658
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201210315081.5A Expired - Fee Related CN103652939B (zh) | 2012-08-30 | 2012-08-30 | 多种维生素c胶囊 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103652939B (zh) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104544047B (zh) * | 2014-12-11 | 2016-08-24 | 广西南宁智翠科技咨询有限公司 | 一种原橙味维生素c钠口含片及其制备工艺 |
| CN104605374A (zh) * | 2014-12-11 | 2015-05-13 | 张莘蔓 | 一种原水蜜桃味维生素c钠口含片及其制备工艺 |
| CN108175104A (zh) * | 2018-01-18 | 2018-06-19 | 广东健林生物科技有限公司 | 一种高维生素c含量咀嚼片及其制作方法 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1047450A (zh) * | 1990-03-12 | 1990-12-05 | 河南省淅川制药厂 | 防氧化的二价铁剂和维生素c复合剂 |
| CN1546061A (zh) * | 2003-12-12 | 2004-11-17 | 黄爱强 | 维生素c钠胶囊 |
| CN101700236A (zh) * | 2009-09-14 | 2010-05-05 | 蔡晓东 | 维生素c软胶囊 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6352713B1 (en) * | 1999-12-01 | 2002-03-05 | Drugtech Corporation | Nutritional composition |
-
2012
- 2012-08-30 CN CN201210315081.5A patent/CN103652939B/zh not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1047450A (zh) * | 1990-03-12 | 1990-12-05 | 河南省淅川制药厂 | 防氧化的二价铁剂和维生素c复合剂 |
| CN1546061A (zh) * | 2003-12-12 | 2004-11-17 | 黄爱强 | 维生素c钠胶囊 |
| CN101700236A (zh) * | 2009-09-14 | 2010-05-05 | 蔡晓东 | 维生素c软胶囊 |
Non-Patent Citations (1)
| Title |
|---|
| 尤启冬.维生素C类.《药物化学》.中国医药科技出版社,2011,(第二版),第513-516页. * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103652939A (zh) | 2014-03-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2733455T3 (es) | Suplementos nutricionales multivitamínicos y minerales | |
| CN102771869A (zh) | 一种胶原蛋白饮料制剂及其制备方法 | |
| CN108391811A (zh) | 一种肿瘤全营养配方食品及其应用 | |
| AU2010212456B2 (en) | Formulas comprising calcium, magnesium, zinc, and vitamin D3, for the prevention and amelioration of osteoporosis | |
| RU2463811C1 (ru) | Специализированный продукт для питания спортсменов | |
| CN102823857A (zh) | 一种人参阿胶保健食品 | |
| CN103652939B (zh) | 多种维生素c胶囊 | |
| CN1315418C (zh) | 黑木耳燕麦螺旋藻即冲饮品及其制备方法 | |
| RU2665635C2 (ru) | Мультивитаминная/минеральная композиция для борьбы с эффектами экологического стресса; повышения иммунитета и повышения активности, направленная на недостаточности витаминов и минералов без негативных побочных эффектов мегадозовой пищевой добавки | |
| CN105878397A (zh) | 一种调节牛羊运输应激组合物 | |
| CN102150838A (zh) | 一种减肥组合物，包含组合物的制剂及其制备方法 | |
| CN112956538A (zh) | 一种火麻仁抹茶代餐奶昔及其制备方法 | |
| CN105581331B (zh) | 一种补钙营养组合物 | |
| CN102028230B (zh) | 一种保健品辅料及其应用 | |
| CN102771793A (zh) | 一种多种维生素制剂及其制备方法 | |
| US20180169071A1 (en) | Nutritional supplement composition | |
| CN108851037A (zh) | 一种肾病综合征全营养食品的制备方法及其用途 | |
| CN108450964A (zh) | 治疗和预防女性经期综合症的保健组合物及其制备方法 | |
| CN102579956A (zh) | 一种药物组合物及其应用 | |
| CA2816207C (en) | Formulas comprising highly soluble elements and vitamin for the prevention and amelioration of osteoporosis | |
| US20160022594A1 (en) | Soft gel encapsulation | |
| CN103417764A (zh) | 含有左旋肉碱的保健品 | |
| CN102318832A (zh) | 一种提高机体耐缺氧能力的营养剂 | |
| KR101100904B1 (ko) | 세포내 지질 부착물 제거를 자극하는 비타민, 미네랄 및미량원소로 이루어진 새로운 상승작용성 조성물 | |
| CN1191764C (zh) | 一种补血保健食品 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20150401 Termination date: 20210830 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |