CN103649069B - 闪光和辉光1,2-二氧杂环丁烷类 - Google Patents

闪光和辉光1,2-二氧杂环丁烷类 Download PDF

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Publication number
CN103649069B
CN103649069B CN201280021603.9A CN201280021603A CN103649069B CN 103649069 B CN103649069 B CN 103649069B CN 201280021603 A CN201280021603 A CN 201280021603A CN 103649069 B CN103649069 B CN 103649069B
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enzyme
carbon atoms
group
light
compound
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CN103649069A (zh
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A.米哈利
B.爱德华兹
Z.王
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Life Technologies Corp
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Life Technologies Corp
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/42—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving phosphatase
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D321/00—Heterocyclic compounds containing rings having two oxygen atoms as the only ring hetero atoms, not provided for by groups C07D317/00 - C07D319/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/6551—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a four-membered ring
    • C07F9/65512—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a four-membered ring condensed with carbocyclic rings or carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/78—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N31/00—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods
    • G01N31/22—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods using chemical indicators
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • H—ELECTRICITY
    • H10—SEMICONDUCTOR DEVICES; ELECTRIC SOLID-STATE DEVICES NOT OTHERWISE PROVIDED FOR
    • H10P—GENERIC PROCESSES OR APPARATUS FOR THE MANUFACTURE OR TREATMENT OF DEVICES COVERED BY CLASS H10
    • H10P14/00—Formation of materials, e.g. in the shape of layers or pillars
    • H10P14/20—Formation of materials, e.g. in the shape of layers or pillars of semiconductor materials
    • H10P14/32—Formation of materials, e.g. in the shape of layers or pillars of semiconductor materials characterised by intermediate layers between substrates and deposited layers
    • H10P14/3202—Materials thereof
    • H10P14/3241—Materials thereof being conductive materials

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plasma & Fusion (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN201280021603.9A 2011-05-03 2012-04-30 闪光和辉光1,2-二氧杂环丁烷类 Active CN103649069B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201161482134P 2011-05-03 2011-05-03
US61/482,134 2011-05-03
US61/482134 2011-05-03
PCT/US2012/035732 WO2012151142A2 (en) 2011-05-03 2012-04-30 Flash and glow 1,2-dioxetanes

Publications (2)

Publication Number Publication Date
CN103649069A CN103649069A (zh) 2014-03-19
CN103649069B true CN103649069B (zh) 2016-09-14

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CN201280021603.9A Active CN103649069B (zh) 2011-05-03 2012-04-30 闪光和辉光1,2-二氧杂环丁烷类

Country Status (6)

Country Link
US (4) US20140154675A1 (https=)
EP (1) EP2705031B1 (https=)
JP (2) JP2014516947A (https=)
KR (1) KR101960113B1 (https=)
CN (1) CN103649069B (https=)
WO (1) WO2012151142A2 (https=)

Families Citing this family (6)

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Publication number Priority date Publication date Assignee Title
EP3211050A1 (en) * 2016-02-26 2017-08-30 Trinseo Europe GmbH Molded structures of polycarbonate based substrates over molded with silicone rubbers
TWI767937B (zh) 2016-09-09 2022-06-21 美商卡利泰拉生物科技公司 外核苷酸酶抑制劑及其使用方法
JP7138351B2 (ja) 2016-12-22 2022-09-16 キャリセラ バイオサイエンシーズ， インコーポレイテッド エクトヌクレオチダーゼ阻害剤およびその使用方法
AU2019288495B2 (en) 2018-06-21 2024-02-08 Antengene Therapeutics Limited Ectonucleotidase inhibitors and methods of use thereof
WO2021086977A1 (en) * 2019-10-28 2021-05-06 Beckman Coulter, Inc. Rapid, high-intensity chemiluminescent dioxetanes
WO2025160017A1 (en) * 2024-01-26 2025-07-31 Beckman Coulter, Inc. Assay methods using chemiluminescent dioxetane compounds

Citations (1)

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Publication number Priority date Publication date Assignee Title
US5780649A (en) * 1995-09-08 1998-07-14 Takasago International Corporation Process for preparing optically active cyclic compounds

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CA1340590C (en) 1986-07-24 1999-06-08 John C. Voyta Chemiluminescence enhancement
US5582980A (en) * 1989-07-17 1996-12-10 Tropix, Inc. Chemiluminescent 1,2-dioxetanes
US5538847A (en) * 1989-07-17 1996-07-23 Tropix, Inc. Chemiluminescent 1,2-dioxetanes
US4952707A (en) * 1988-06-30 1990-08-28 Tropix, Inc. Enzymatically-cleavable chemiluminescent fused polycyclic ring-containing 1,2-dioxetanes
US5326882A (en) * 1989-07-17 1994-07-05 Tropix, Inc. Chemiluminescent 3-(substituted Adamant-2'-Ylidene) 1,2-dioxetanes
US5547836A (en) 1990-08-30 1996-08-20 Tropix, Inc. Enhancement of chemiluminescent assays
US5994073A (en) 1990-08-30 1999-11-30 Tropix, Inc. Enhancement of chemiluminescent assays
US5603868A (en) * 1992-10-30 1997-02-18 Abbott Laboratories Chemiluminescent electron-rich aryl-substituted 1,2-dioxetanes
US5773628A (en) * 1994-11-14 1998-06-30 Tropix, Inc. 1,2-dioxetane compounds with haloalkoxy groups, methods preparation and use
JPH11500222A (ja) * 1995-02-13 1999-01-06 トロピックス・インコーポレーテッド 化学ルミネセンスエネルギー移動アッセイ
JPH08245615A (ja) * 1995-03-11 1996-09-24 Masakatsu Matsumoto １，２−ジオキセタン誘導体
US5679803A (en) * 1995-10-25 1997-10-21 Tropix, Inc. 1,2 chemiluminescent dioxetanes of improved performance
WO1997014692A1 (en) * 1995-10-17 1997-04-24 Tropix, Inc. 1,2 chemiluminescent dioxetanes of improved performance
US6660529B2 (en) * 1998-07-28 2003-12-09 Pe Corporation Heteroaryl substituted benzothiazole dioxetanes
CA2338883A1 (en) * 1998-07-28 2000-02-10 Tropix, Inc. Benzothiazole dioxetanes
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EP1735621A4 (en) * 2004-04-14 2012-12-12 Brij P Giri NEW ULTRA-SENSITIVE CHEMIELUMINESCENSE SUBSTRATES FOR ENZYMES AND THEIR CONJUGATES
US20060079699A1 (en) * 2004-08-27 2006-04-13 Brooks Edwards Intermediate compounds and methods for synthesizing chemiluminescent dioxetane substrates
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CN101784897A (zh) * 2007-05-23 2010-07-21 应用生物系统有限公司 通过从活化的化学发光的基质将能量转移至能量受体染料来检测生物分子的试剂、试剂盒和方法
WO2009139811A2 (en) * 2008-05-15 2009-11-19 Tianxin Wang Chemiluminescent methods and reagents for analyte detection
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US5780649A (en) * 1995-09-08 1998-07-14 Takasago International Corporation Process for preparing optically active cyclic compounds

Non-Patent Citations (1)

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Title
A Novel Substitution Process for the Preparation of Alkoxy-, Aryloxy-, and Acyloxy-Substituted 1,2-Dioxetanes;Hashem Akhavan-Tafti et al.;《J. Am. Chem. Soc.》;19971231;第119卷(第1期);第245-246页 *

Also Published As

Publication number Publication date
JP6440265B2 (ja) 2018-12-19
JP2014516947A (ja) 2014-07-17
US20170321245A1 (en) 2017-11-09
HK1193608A1 (zh) 2014-09-26
US20140154675A1 (en) 2014-06-05
KR20140039213A (ko) 2014-04-01
WO2012151142A2 (en) 2012-11-08
CN103649069A (zh) 2014-03-19
WO2012151142A3 (en) 2013-01-10
EP2705031A2 (en) 2014-03-12
JP2017039743A (ja) 2017-02-23
EP2705031B1 (en) 2018-04-11
KR101960113B1 (ko) 2019-03-19
US20200056222A1 (en) 2020-02-20
US20220010356A1 (en) 2022-01-13

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