CN103638349A - Application of honeysuckle forsythia powder in preparation of medicine for treating seborrheic dermatitis - Google Patents
Application of honeysuckle forsythia powder in preparation of medicine for treating seborrheic dermatitis Download PDFInfo
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- CN103638349A CN103638349A CN201310592063.6A CN201310592063A CN103638349A CN 103638349 A CN103638349 A CN 103638349A CN 201310592063 A CN201310592063 A CN 201310592063A CN 103638349 A CN103638349 A CN 103638349A
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Abstract
The invention belongs to the technical field of medicines, relates to a new use of Chinese patent medicine, and particularly relates to application of honeysuckle forsythia powder in preparation of medicine for treating seborrheic dermatitis. The prescription and a preparation method of the honeysuckle forsythia powder are as follows:ten traditional Chinese medicines of honeysuckle, fructus forsythia, platycodon grandiflorum, mint, fermented soybean, lophatherum gracile, burdock, herba schizonepetae, reed rhizome and liquorice are crushed into fine powder, sieved and mixed evenly to obtain the honeysuckle forsythia powder. The honeysuckle forsythia powder has the functions of cooling and expelling surficial evils and clearing heat and removing toxicity, and can treat the seborrheic dermatitis by oral administration.
Description
Technical field
The invention belongs to medical technical field, relate to a kind of new purposes of Chinese patent medicine, be specifically related to the application of Lonicerae and Forsythiae Powder in preparation treatment seborrheic dermatitis medicine.
Background technology
Seborrheic dermatitis is that sebaceous gland secretory function is hyperfunction in body, and the discharge that sebum is too much and being deposited on skin makes accumulation place skin generation chronic inflammation pathological changes.Be common in adolescence or adult patients that smegma is vigorous, be apt to occur in the sebaceous gland more place that distributes, as scalp, face, chest and gauffer portion.Due to the change of people's living habit and dietary habit and more and more make to apply some make up, seborrheic dermatitis in recent years, the sickness rate of especially facial seborrheic dermatitis raises year by year.By erythra performance difference, can be divided into dryness and moist two classes, dryness mostly is the infringement of erythema desquamation, mostly moistly is pimple, vesicle, can produces erosion, overflows and form yellow crust after scratching, and unbearably, the state of an illness is slow for normal pruritus, outbreak repeatedly.The seborrheic dermatitis of face is often spread by scalp, is yellowish red color or greasy scales macule.The pathogenic factor of seborrheic dermatitis it be unclear that, it is generally acknowledged relevant with gonad parasecretion, due to androgen hypersecretion.In addition, have scholar think may with immunity, heredity, hormone, nerve and environmental factors, digestive function is not normal, sugar, hyperliposis, psychentonia, overworked, antibacterial infects, vitamin B complex lacks, mite infections etc. have certain relation.
The method of the facial seborrheic dermatitis for the treatment of is varied at present, have adopt refrigerant Herba Menthae cream to be evenly applied to facial affected part can inflammation-inhibiting, repair impaired horny layer, the skin itch causing for facial erythema, pimple, decortication and cosmetic allergic contact dermatitis, ultraviolet burn etc. has the effect of Quick itch stopping.Adopt in addition topical class steroid hormone preparation, although have to a certain extent antiinflammatory, antiallergic, antipruritic effect, life-time service can cause atrophoderma, telangiectasis, and acne sample rash etc., and also after stopping using, erythra is easily repeatedly.Conventional local application is: with dissolved fat, cutin strips off, anti-inflammatory analgetic is antipruritic is main, common drug has sulfur, Lei Xinxin, coal tar, salicylic acid, selenium sulfide, imidazoles etc. are pressed different parts, available 50% sulfur, Calamine Lotion or 2% ~ 5% sulfur coal tar paste, the local painting of 20% ketone bran azoles frost put on the skin.All exist and be difficult to radical cure, easily the problem of recurrence.
The product effect for the treatment of seborrheic dermatitis is all not so good at present, is therefore badly in need of a kind of Chinese medicine for the treatment of seborrheic dermatitis.There is (the accurate word Z11021205 of traditional Chinese medicines Beijing three nine-day periods after the winter solstice pharmaceutcal corporation, Ltd in the current China of Lonicerae and Forsythiae Powder, traditional Chinese medicines Zhun Zi Z52020075 Dechangxiang Medical Industry Co Ltd, Guiyang, traditional Chinese medicines Zhun Zi Z52020281 Guizhou Shunjian Pharmaceutical Co., Ltd., Lonicerae and Forsythiae Powder (traditional Chinese medicines Zhun Zi Z52020467 Guizhou Baihua Pharmaceutical Co., Ltd., 5 productions of Lonicerae and Forsythiae Powder (traditional Chinese medicines Zhun Zi Z52020389 Zunyi Liaoyuan Hetang Pharmaceutical Co., Ltd.).The bibliographical information that also there is no at present its treatment seborrheic dermatitis.
Summary of the invention
Goal of the invention: the object of the present invention is to provide the application of Lonicerae and Forsythiae Powder in preparation treatment seborrheic dermatitis medicine.
Technical scheme: the application of Lonicerae and Forsythiae Powder in preparation treatment seborrheic dermatitis medicine.
The prescription of Lonicerae and Forsythiae Powder and preparation method are: Flos Lonicerae 100g, Fructus Forsythiae 100g, Radix Platycodonis 60g, Herba Menthae 60g, tasteless preserved soybean 50g, Herba Lophatheri 40g, Fructus Arctii 60g, Herba Schizonepetae 40g, Rhizoma Phragmitis 100g, Radix Glycyrrhizae 40g, above ten tastes, be ground into fine powder, sieve, mix, obtain.There is the pungent table that cools completely, the effect of heat-clearing and toxic substances removing.Clinical in anemopyretic cold, fever and headache, xerostomia cough, has sore throat, oliguria with reddish urine.Now find that it orally can treat seborrheic dermatitis.
Beneficial effect: Lonicerae and Forsythiae Powder treatment seborrheic dermatitis, respond well.
The specific embodiment
Below in conjunction with specific embodiment, the present invention is further described, so that those skilled in the art more understands the present invention, but does not therefore limit the present invention.
The specific embodiment
The clinical data of Lonicerae and Forsythiae Powder treatment seborrheic dermatitis
Clinical medicine:
Tacrolimus ointment, (specification: 10 g/ prop up), Japanese Teng Ze company, lot number is 15523.
Lonicerae and Forsythiae Powder, Beijing three nine-day periods after the winter solstice pharmaceutcal corporation, Ltd, lot number: 20110308.
The routine facial patients with seborrheic dermatitis of 1.1 physical data 144 all meets Ministry of Public Health < < new Chinese medicine guideline of clinical investigations > > seborrheic dermatitis in 1997 diagnostic criteria.
Male 55 examples wherein, female's 89 examples, are divided into two groups of each 72 examples at random, matched group man 28 examples, female's 44 examples; 17 ~ 54 years old age, average 29.1 years old; The course of disease 0.3 ~ 15 a, average 4.5 a.Treatment group man 27 examples, female's 45 examples; 16 ~ 53 years old age, average 28.6 years old; The course of disease 0.3 ~ 15 a, average 4.5 a.The sex of two groups, age, the equal no significant difference of the state of an illness, P>0.05.Treat the front medicine of not using any treatment primary disease for 1 week, during treatment, do not use other treatment to take orally and external used medicine.
1.2 Therapeutic Method
The routine patient of matched group 72 adopts 0.1% tacrolimus ointment (specification: 10 g/ prop up), 2 times/d of skin lesion position external, 4 weeks courses for the treatment of.
The routine patient for the treatment of group 72 adopts Lonicerae and Forsythiae Powder to carry out oral medication, and warm water is swallowed or boiled water is taken after being infused in hot water or decoction, one time 1 bag (every bag 6g), 2～3 times on the one.
During treatment, two groups all give low fat light diet, prohibit pungent irritable food, observe patient simultaneously and have no adverse reaction, record patient therapeutic effect.
After finishing the course for the treatment of, 1.3 curative effect determinate standards 4 week carry out therapeutic evaluation, according to clinical symptoms and sign: the degree of skin lesion size, erythema, desquamation, seborrhea and pruritus is evaluated.Clinical recovery: clinical symptoms and sign disappear more than 95%; Effective: clinical symptoms and sign go down 80% ~ 94%; Effective: clinical symptoms and sign alleviate more than 50%; Invalid: clinical symptoms and sign are improved below 50%.
2 results
The routine patient of matched group 72, clinical recovery 26 examples, effective 15 examples, effective 9 examples, invalid 22 examples, total effective rate is 69.44%, in therapeutic process, there are 4 routine patients to occur insufferable skin pruritus, in the situation that not applying other antipruritic agents, pruritus symptom spontaneous remission after 3 ~ 5 d; The routine patient for the treatment of group 72, clinical recovery 38 examples, effective 17 examples, effective 11 examples, invalid 6 examples, total effective rate is that symptom of diarrhea appears in 91.67%, 1 routine patient, spontaneous remission after 1 d.Two groups of total effective rates compare χ 2=11.35, and P<0.01, has significant difference.
Claims (1)
1. the application of Lonicerae and Forsythiae Powder in preparation treatment seborrheic dermatitis medicine.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310592063.6A CN103638349A (en) | 2013-11-22 | 2013-11-22 | Application of honeysuckle forsythia powder in preparation of medicine for treating seborrheic dermatitis |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201310592063.6A CN103638349A (en) | 2013-11-22 | 2013-11-22 | Application of honeysuckle forsythia powder in preparation of medicine for treating seborrheic dermatitis |
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| CN103638349A true CN103638349A (en) | 2014-03-19 |
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| CN201310592063.6A Pending CN103638349A (en) | 2013-11-22 | 2013-11-22 | Application of honeysuckle forsythia powder in preparation of medicine for treating seborrheic dermatitis |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108607046A (en) * | 2016-12-13 | 2018-10-02 | 河南后羿实业集团有限公司 | A kind of animal compound Lonicera and Forsythia oral solution and preparation method thereof |
-
2013
- 2013-11-22 CN CN201310592063.6A patent/CN103638349A/en active Pending
Non-Patent Citations (2)
| Title |
|---|
| 左言富等: "《简明中成药辞典》", 31 October 2002 * |
| 李浩然: ""宣肺法治疗皮肤病举隅"", 《新疆中医药》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108607046A (en) * | 2016-12-13 | 2018-10-02 | 河南后羿实业集团有限公司 | A kind of animal compound Lonicera and Forsythia oral solution and preparation method thereof |
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Application publication date: 20140319 |