CN103463570B - Pharmaceutical composition and preparation method, preparation and application thereof - Google Patents
Pharmaceutical composition and preparation method, preparation and application thereof Download PDFInfo
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Abstract
The invention discloses a pharmaceutical composition and a preparation method, a preparation and an application thereof. The pharmaceutical composition is mainly composed of the following main components: 5-7 parts of cortex moutan, 5-7 parts of radix paeoniae alba, 3-6 parts of radix curcumae, 3-6 parts of gardenia, 4-7 parts of lily, 4-7 parts of tuckahoe, 4-7 parts of angelica, 5-7 parts of bighead atractylodes rhizome, 4-6 parts of mint and 3-5 parts of rhizoma cyperi. The preparation method comprises the following steps: firstly, sorting all raw materials, removing impurities, and then, crushing the raw materials to powder through a crusher, and finally, uniformly mixing and packaging the powder to obtain the preparation disclosed by the invention. The preparation disclosed by the invention is convenient to take, low in cost and good in curative effect on such skin diseases as acne, comedo, eczema, chloasma, seborrheic dermatitis, bacterial skin infection, alopecia seborrheica and neuropathic alopecia, the total effective rate reaches 90%, the basic cure rate reaches 70%, and the average effective time is 27 days. Furthermore, the pharmaceutical composition has no side effect.
Description
Technical field
The invention belongs to application in TCM technical field, be specifically related to one and treat dermopathic pharmaceutical composition and preparation method thereof, preparation and application.
Background technology
Dermatosis is one of the commonly encountered diseases, frequently-occurring disease that have a strong impact on people ' s health, as acne, acne, eczema, chloasma, seborrheic dermatitis, bacterial skin infections, seborrheic alopecia and nervous alopecia etc.Dermatosis is that after skin (comprising hair and first) is subject to the impact of internal and external factor, its form, 26S Proteasome Structure and Function all change, and produces pathological process, and the various clinical priority performance of corresponding generation.Impact morbidity many factors, wherein topmost virulence factor often with diet, social mentality, climatic environment etc. because have close relationship.Modern medicine is thought, a lot of dermatosis is the outward manifestation of viscera disease, because unhygienic diet or uncontrolled, social life are discord, the factors such as climatic environment deterioration, cause crowd's body and psychology to be difficult to adapt to many changes, thus cause body's immunity unbalance, cell division is abnormal, organism metabolic disorder, immunologic function is unbalance, endocrine regulation, free radical toxin dysbolismus, even has indirect or direct relation with spirit, neural pathological change.How relatively lighter, often not unhealthful dermopathic sickness rate is very high, but minority is heavier even can threat to life.Be used for the treatment of the dermopathic medicines such as acne, acne, eczema, chloasma, seborrheic dermatitis, bacterial skin infections, seborrheic alopecia and nervous alopecia at present a lot, mostly containing hormones composition in its Chinese medicine and western medicine ointment, but life-time service can produce harmful effect to human body, cause patient cannot adhere to treatment.Also have some traditional Chinese medicine product to be used to treat this type of dermatosis, but major part all needs to decoct, take inconvenience, treatment cost is high, and curative effect is unsatisfactory.Therefore, develop one and take aspect, with low cost, it is very necessary that curative effect preferably treats dermopathic pharmaceutical composition.
Summary of the invention
The first object of the present invention is to provide a kind of and is suitable for that crowd is wide, taking convenience, with low cost, have no side effect, evident in efficacy, the pharmaceutical composition of common skin diseases can be treated; Second object is the preparation method providing described pharmaceutical composition; 3rd object is the preparation providing described pharmaceutical composition, and the 4th object is the application providing described pharmaceutical composition.
The first object of the present invention is achieved in that described pharmaceutical composition consists of Cortex Moutan 5 ~ 7 parts, the Radix Paeoniae Alba 5 ~ 7 parts, Radix Curcumae 3 ~ 6 parts, Fructus Gardeniae 3 ~ 6 parts, Bulbus Lilii 4 ~ 7 parts, 4 ~ 7 parts, Poria, Radix Angelicae Sinensis 4 ~ 7 parts.
The second object of the present invention is achieved in that and first sorts all raw materials, removes impurities, then uses pulverizer raw material pulverizing powdered, finally subpackage after mixing.
The third object of the present invention is achieved in that described pharmaceutical composition adds medically acceptable adjuvant and makes powder, capsule, tablet, granule, pill or oral liquid.
The fourth object of the present invention is achieved in that described pharmaceutical composition is preparing the application in Acne treatment, acne, eczema, chloasma, seborrheic dermatitis, bacterial skin infections, seborrheic alopecia and nervous alopecia medicine.
The present invention also provides the preparation method of aforementioned pharmaceutical compositions: comprise first by all material sorting, remove impurity, then use pulverizer raw material pulverizing powdered, powder is by 60 ~ 100 object screen clothes, it is broken that what granule was larger return pulverizer relaying continued powder, and finally subpackage after mixing, can be distributed into 3 ~ 10g and often wrap, after obtaining mixing drug powder basis on, the medicine of the types such as powder, capsule, tablet, granule, pill or oral liquid can be made according to conventional methods.
The instructions of taking of pharmaceutical composition of the present invention: every day 2 ~ 3 times, count 3 ~ 10g at every turn, take with warm water with crude drug weight, a course for the treatment of is 25 ~ 35 days.Take period and avoid sugar and greasy food.
Product of the present invention is used for the treatment of the multiple head-face skin disease such as acne, acne, eczema, chloasma, seborrheic dermatitis, bacterial skin infections, seborrheic alopecia and nervous alopecia and has good effect, effective percentage reaches 97%, and basic cure rate reaches 70%.
According to the Pharmacopoeia of the People's Republic of China (nineteen ninety-five version), the Cortex Moutan in product of the present invention possesses clearing away heat and cooling blood, effect of blood circulation promoting and blood stasis dispelling; The Radix Paeoniae Alba possesses suppressing the hyperactive liver pain relieving, effect of nourishing blood for regulating menstruation; Radix Curcumae possesses promoting QI circulation for relieving depression, effect of menstruction regulating and pain relieving; Fructus Gardeniae possesses pathogenic fire purging relieving restlessness, effect of clearing away heat and promoting diuresis; Bulbus Lilii possesses lung moistening of nourishing blood, effect of clearing away heart-fire for tranquillization; Poria possesses diuretic and oozes spleen, effect of spleen invigorating mind calming; The Rhizoma Atractylodis Macrocephalae possesses spleen reinforcing stomach reinforcing, dampness and in effect; Herba Menthae possesses wind-dispelling heat-dissipating, keeps away effect of dirty removing toxic substances; Rhizoma Cyperi possesses resolving depression of regulating the flow of vital energy, effect of pain relieving regulating menstruation.The present invention, by these drug regimens, coordinates between each composition mutually, can receive good QI and blood regulating, and speckle removing removes rash, the effects such as detoxification mind calming.The powder that inventor applies gained pharmaceutical composition is treated clinical case, and adds up, and result is as following table:
| Dermatosis | Number of cases/people | Healing/people | Effective/people | Effectively/people | Invalid/people | Effective percentage/% |
| Acne | 50 | 46 | 0 | 46 | 4 | 92 |
| Acne | 36 | 32 | 1 | 33 | 3 | 92 |
| Eczema | 42 | 38 | 1 | 39 | 3 | 93 |
| Chloasma | 38 | 33 | 2 | 35 | 3 | 92 |
| Seborrheic dermatitis | 25 | 20 | 3 | 23 | 2 | 92 |
| Bacterial skin infections | 28 | 20 | 4 | 24 | 4 | 86 |
| Seborrheic alopecia | 24 | 20 | 2 | 22 | 2 | 91 |
| Nervous alopecia | 20 | 15 | 3 | 18 | 2 | 90 |
The standard of curing is that skin surface affected part area reduces.Effective standard does not increase new skin lesion.Effective standard to alleviate patient suffering.Invalid standard is the beneficial effect not occurring perceiving.
Show according to practice, it is wide that pharmaceutical composition of the present invention is suitable for crowd, remarkable result is had to the people of all age group, without the need to decocting when taking, can be taken after mixing with liquid by direct warm water, consumption is few, preparation cost is low, and product is pure Chinese medicinal preparation, without any side effects, and patient's long-term taking also has no any harmful effect.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is further illustrated, but limited the present invention never in any form, and any conversion done based on training centre of the present invention or replacement, all belong to protection scope of the present invention.
Pharmaceutical composition of the present invention consists of Cortex Moutan 5 ~ 7 parts, the Radix Paeoniae Alba 5 ~ 7 parts, Radix Curcumae 3 ~ 6 parts, Fructus Gardeniae 3 ~ 6 parts, Bulbus Lilii 4 ~ 7 parts, 4 ~ 7 parts, Poria, Radix Angelicae Sinensis 4 ~ 7 parts.
Described pharmaceutical composition consists of Cortex Moutan 6 parts, the Radix Paeoniae Alba 6 parts, Radix Curcumae 4.5 parts, Fructus Gardeniae 4.5 parts, Bulbus Lilii 6 parts, 6 parts, Poria, Radix Angelicae Sinensis 6 parts.
Described pharmaceutical composition also comprises the Rhizoma Atractylodis Macrocephalae 5 ~ 7 parts, Herba Menthae 4 ~ 6 parts, Rhizoma Cyperi 3 ~ 5 parts.
The described Rhizoma Atractylodis Macrocephalae is 6 parts, and Herba Menthae is 4.5 parts, and Rhizoma Cyperi is 4.5 parts.
The method of preparation of the present invention pharmaceutical composition according to claim 1, first sorts all raw materials, removes impurities, then uses pulverizer raw material pulverizing powdered, finally subpackage after mixing.
Described subpackage carries out subpackage according to the weight of often wrapping 3 ~ 10g.
Described powder diameter is 60 ~ 100 orders.
Preparation of the present invention is that described pharmaceutical composition adds medically acceptable adjuvant and makes powder, capsule, tablet, granule, pill or oral liquid.
Of the present inventionly be applied as described pharmaceutical composition and preparing the application in Acne treatment, acne, eczema, chloasma, seborrheic dermatitis, bacterial skin infections, seborrheic alopecia and nervous alopecia medicine.
Illustrate below and the present invention be described in more detail:
Embodiment 1
Raw material is got ready according to the ratio of Cortex Moutan 5 parts, the Radix Paeoniae Alba 5 parts, Radix Curcumae 3 parts, Fructus Gardeniae 3 parts, Bulbus Lilii 4 parts, 4 parts, Poria, Radix Angelicae Sinensis 4 parts, after picking various impurity, various raw material pulverizing is made powder, after pulverizing, powder is through 60 object screen clothes, the unsanctioned pulverizer that returns continues to pulverize, until whole powder is by 60 object screen clothes, gained powder mix homogeneously, the specification subpackage often wrapped with 10g.
Embodiment 2
According to Cortex Moutan 5 parts, the Radix Paeoniae Alba 5 parts, Radix Curcumae 3 parts, Fructus Gardeniae 3 parts, Bulbus Lilii 4 parts, 4 parts, Poria, Radix Angelicae Sinensis 4 parts, the Rhizoma Atractylodis Macrocephalae 5 parts, Herba Menthae 4 parts, the ratio that Rhizoma Cyperi is 3 parts gets raw material ready, after picking various impurity, various raw material pulverizing is made powder, after pulverizing, powder is through 80 object screen clothes, and the unsanctioned pulverizer that returns continues to pulverize, until whole powder is by 80 object screen clothes, gained powder mix homogeneously, the specification subpackage often wrapped with 10g.
Embodiment 3
Raw material is got ready according to the ratio of Cortex Moutan 6 parts, the Radix Paeoniae Alba 6 parts, Radix Curcumae 4.5 parts, Fructus Gardeniae 4.5 parts, Bulbus Lilii 6 parts, 6 parts, Poria, Radix Angelicae Sinensis 6 parts, after picking various impurity, various raw material pulverizing is made powder, after pulverizing, powder is through 100 object screen clothes, the unsanctioned pulverizer that returns continues to pulverize, until whole powder is by 100 object screen clothes, gained powder mix homogeneously, the specification subpackage often wrapped with 6g.
Embodiment 4
According to Cortex Moutan 6 parts, the Radix Paeoniae Alba 6 parts, Radix Curcumae 4.5 parts, Fructus Gardeniae 4.5 parts, Bulbus Lilii 6 parts, 6 parts, Poria, Radix Angelicae Sinensis 6 parts, the Rhizoma Atractylodis Macrocephalae 6 parts, Herba Menthae 4.5 parts, the ratio that Rhizoma Cyperi is 4.5 parts gets raw material ready, after picking various impurity, various raw material pulverizing is made powder, after pulverizing, powder is through 100 object screen clothes, and the unsanctioned pulverizer that returns continues to pulverize, until whole powder is by 100 object screen clothes, gained powder mix homogeneously, the specification subpackage often wrapped with 6g.
Embodiment 5
Raw material is got ready according to the ratio of Cortex Moutan 7 parts, the Radix Paeoniae Alba 7 parts, Radix Curcumae 6 parts, Fructus Gardeniae 6 parts, Bulbus Lilii 7 parts, 7 parts, Poria, Radix Angelicae Sinensis 7 parts, after picking various impurity, various raw material pulverizing is made powder, after pulverizing, powder is through 80 object screen clothes, the unsanctioned pulverizer that returns continues to pulverize, until whole powder is by 80 object screen clothes, gained powder mix homogeneously, the specification subpackage often wrapped with 3g.
Embodiment 6
According to Cortex Moutan 7 parts, the Radix Paeoniae Alba 7 parts, Radix Curcumae 6 parts, Fructus Gardeniae 6 parts, Bulbus Lilii 7 parts, 7 parts, Poria, Radix Angelicae Sinensis 7 parts, the Rhizoma Atractylodis Macrocephalae 7 parts, Herba Menthae 6 parts, the ratio that Rhizoma Cyperi is 5 parts gets raw material ready, after picking various impurity, various raw material pulverizing is made powder, after pulverizing, powder is through 80 object screen clothes, and the unsanctioned pulverizer that returns continues to pulverize, until whole powder is by 80 object screen clothes, gained powder mix homogeneously, the specification subpackage often wrapped with 3g.
Clinical practice:
Lee's ××, man, 30 years old, athlete.Suffer from acne for many years, use other Chinese medicine and western medicine to carry out the treatment several years, curative effect is also not obvious, and through taking the product described in the embodiment of the present invention 2 after 25 days, skin lesion disappears more than 90%, and advise and take 27 days again, skin lesion disappears completely, is almost recovered.
Old ×, female, 17 years old, student.Suffer from more than acne year, use the western medicines in treatment such as viaminate, jinhuaxiaocuo pill, curative effect is dissatisfied, and through taking the product described in the embodiment of the present invention 2 after 30 days, skin lesion disappears more than 90%, is almost recovered, and follows up a case by regular visits to after half a year, and erythra does not recur.
King's ××, female, 45 years old, company clerk.Suffer from chloasma nearly 2 years, use other drug treatment, curative effect is not obvious.Take product described in the embodiment of the present invention 3 after 27 days, skin lesion disappears more than 90%, is almost recovered.
Zhu's ××, man, 50 years old, workman.Suffer from a seborrheic dermatitis, use the product of the embodiment of the present invention 6 after 27 days, deflorescence more than 90%, follow up a case by regular visits to after 1 year, the state of an illness does not recur.
Open ××, man, 45 years old, cadre.Suffer from seborrheic alopecia, use the product of the embodiment of the present invention 5 after 29 days, alopecia has clear improvement, and scalp oils and fats reduces, and the state of an illness is almost recovered.
Clinical application practice illustrates, the patient of product of the present invention to various ages has good therapeutical effect, and all has good therapeutic effect in multiple head-face skin diseases such as Acne treatment, chloasma, eczema, seborrheic dermatitis.Total effective rate reaches 90%, and basic cure rate reaches 70%, and average effective time is 25 days.
Claims (9)
1. a pharmaceutical composition for Acne treatment, eczema, chloasma, seborrheic dermatitis, bacterial skin infections, seborrheic alopecia and nervous alopecia, is characterized in that: described drug regimen raw material consists of Cortex Moutan 5 ~ 7 parts, the Radix Paeoniae Alba 5 ~ 7 parts, Radix Curcumae 3 ~ 6 parts, Fructus Gardeniae 3 ~ 6 parts, Bulbus Lilii 4 ~ 7 parts, 4 ~ 7 parts, Poria, Radix Angelicae Sinensis 4 ~ 7 parts.
2. pharmaceutical composition according to claim 1, is characterized in that: described pharmaceutical composition consists of Cortex Moutan 6 parts, the Radix Paeoniae Alba 6 parts, Radix Curcumae 4.5 parts, Fructus Gardeniae 4.5 parts, Bulbus Lilii 6 parts, 6 parts, Poria, Radix Angelicae Sinensis 6 parts.
3. the pharmaceutical composition of an Acne treatment, eczema, chloasma, seborrheic dermatitis, bacterial skin infections, seborrheic alopecia and nervous alopecia, it is characterized in that: described drug regimen raw material consists of Cortex Moutan 5 ~ 7 parts, the Radix Paeoniae Alba 5 ~ 7 parts, Radix Curcumae 3 ~ 6 parts, Fructus Gardeniae 3 ~ 6 parts, Bulbus Lilii 4 ~ 7 parts, 4 ~ 7 parts, Poria, Radix Angelicae Sinensis 4 ~ 7 parts, the Rhizoma Atractylodis Macrocephalae 5 ~ 7 parts, Herba Menthae 4 ~ 6 parts, Rhizoma Cyperi 3 ~ 5 parts.
4. pharmaceutical composition according to claim 3, is characterized in that: the described Rhizoma Atractylodis Macrocephalae is 6 parts, and Herba Menthae is 4.5 parts, and Rhizoma Cyperi is 4.5 parts.
5. according to pharmaceutical composition arbitrary described in claim 1 ~ 4, it is characterized in that: the preparation method of described pharmaceutical composition is all raw materials of sorting, removes impurities, then uses pulverizer raw material pulverizing powdered, finally subpackage after mixing.
6. pharmaceutical composition according to claim 5, is characterized in that: described subpackage carries out subpackage according to the weight of often wrapping 3 ~ 10g.
7. pharmaceutical composition according to claim 5, is characterized in that: described powder diameter is 60 ~ 100 orders.
8. a preparation for arbitrary pharmaceutical composition described in claim 1 ~ 4, is characterized in that: described pharmaceutical composition adds medically acceptable adjuvant and makes powder, capsule, tablet, granule, pill or oral liquid.
9. the arbitrary described pharmaceutical composition of claim 1 ~ 4 is preparing the application in Acne treatment, eczema, chloasma, seborrheic dermatitis, bacterial skin infections, seborrheic alopecia and nervous alopecia medicine.
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| WO2021232334A1 (en) * | 2020-05-21 | 2021-11-25 | 极臣生物科技(深圳)有限公司 | Traditional chinese medicine composition having anti-acne effect, preparation method therefor, and use thereof |
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