CN102114111B - Medicament for treating damp-heat stagnation type acne - Google Patents
Medicament for treating damp-heat stagnation type acne Download PDFInfo
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- CN102114111B CN102114111B CN2011100455535A CN201110045553A CN102114111B CN 102114111 B CN102114111 B CN 102114111B CN 2011100455535 A CN2011100455535 A CN 2011100455535A CN 201110045553 A CN201110045553 A CN 201110045553A CN 102114111 B CN102114111 B CN 102114111B
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Abstract
The invention relates to a medicament using plants as raw materials, in particular to the medicament for treating damp-heat stagnation type acne. The medicament comprises active ingredients and pharmaceutically acceptable excipients, and is characterized in that the active ingredients are prepared by the following active pharmaceutical ingredients by weight percent: 6-12% of artemisia capillaris thunb, 6-12% of baical skullcap root, 11-20% of talc, 6-12% of immature bitter orange, 7-10% of loquat leaf, 8-14% of radix salviae miltiorrhizae, 8-14% of spreading hedyotis herb, 6-10% of common selfheal fruit-spike, 6-10% of red paeony root, 4-7% of Chinese angelica and 4-7% of liquoric root. The active ingredients can be prepared into granules or capsules, thereby having the effects of clearing heat, removing dampness and cooling blood.
Description
Invention field
The present invention relates to the field of Chinese medicines, be specifically related to the Chinese medicine composition that a kind of Chinese crude drug crude drug is processed.
Background technology
Acne is commonly called as " comedo ", " acne ", is a kind of pilosebaceous chronic inflammation disease, is its characteristic with acne, pimple, pustule, tuberosity etc., often accompanies seborrhea, and pilosity is born in the adolescence men and women.The traditional Chinese medical science thinks that the cause of disease that the syndrome of accumulated dampness-heat acne takes place is many because the pungent delicious food savoury of surfeit helps heat of wetting, and damp-heat gluing each other can not be assigned, on steam face and cause.Western medicine thinks and removes the endocrine disturbance, androgen secretion is vigorous cause outer also relevant with some pathogenic bacterial infections, such as pityrosporum furfur, propionibacterium acnes, staphylococcus aureus and acarid etc.Southern area is located in damp and hot ground, and rain is wet to be contained and the weather sweltering heat, and the damp-heat accumulation type acne is multiple, common.The medicine of treatment acne is in the majority with medicine for external use at present, and like Da Fuwen, acne ointment, beauty mask etc., its effect is to eliminate the hair follicle inflammation; Dredging pore; Reduce fat secretion, overweight Zhi Biao and be negligent of effecting a permanent cure outbreak repeatedly easily; Treatment time is long, and external used medicine causes discomforts such as pruritus, desquamation, drying, erythema even anaphylaxis easily mostly.Take Western medicine such as suppressing sebaceous gland function medicament, gonadal hormone and antibiotic for a long time and then cause gastrointestinal reaction, drying, teratogenesis, drug resistance, endocrine disturbance easily, even to untoward reaction such as hepatic and renal function exert an influence, and it is slow to take effect, easy relapse.Therefore, seek that a kind of can to bring into play the popular again damp-heat accumulation type acne method of preventing and treating of tcm characteristic be desirability.
Summary of the invention
The object of the present invention is to provide a kind of medicine of treating the damp-heat accumulation type acne, this medicine has advantages such as good effect, untoward reaction be little.
The inventor is through the massive epidemiology investigation; Find that wet Sheng of heat in blood is the main etiology and pathogenesis of southern area acne morbidity; Wind and heat in the lung meridian, damp-heat accumulation are its main differentiation of symptoms and signs for classification of syndrome; Be more common in the adolescence of oily skin; Erythra is main with blackhead, inflammatory pimple, pustule or tuberosity (being equivalent to pimple, acne pustulosa), and often fester with thirsty, halitosis, laryngopharynx swelling and pain or gingival swelling and pain or hemorrhage, yellow urine and be short of, constipation with dry stool, red tongue with yellowish and greasy fur, rolling pulse, number or equality hygropyrexia symptom.This medicine is a principle with the clearing away heat and cooling blood eliminating dampness method to its main etiology and pathogenesis, be widely used in clinical 10 surplus year, and obtain good curative effect.Concrete technical solution is described below:
A kind of medicine of treating the damp-heat accumulation type acne, this medicine is made up of active ingredient and medically acceptable excipient, it is characterized in that described active ingredient processed by following raw materials by weight percent medicine:
Herba Artemisiae Scopariae 6～12%, Radix Scutellariae 6～12%, Talcum 11～20%, Fructus Aurantii Immaturus 6～12%, Folium Eriobotryae 7～10%, Radix Salviae Miltiorrhizae 8～14%, Herba Hedyotidis Diffusae 8～14%, Spica Prunellae 6～10%, Radix Paeoniae Rubra 6～10%, Radix Angelicae Sinensis 4～7%, Radix Glycyrrhizae 4～7%.
Medicine of the present invention, the optimum ratio of wherein said active ingredient is:
Herba Artemisiae Scopariae 8～10%, Radix Scutellariae 8～10%, Talcum 14～18%, Fructus Aurantii Immaturus 8～10%, Folium Eriobotryae 8～9%, Radix Salviae Miltiorrhizae 10～12%, Herba Hedyotidis Diffusae 10～12%, Spica Prunellae 7～9%, Radix Paeoniae Rubra 7～9%, Radix Angelicae Sinensis 5～6%, Radix Glycyrrhizae 5～6%.
Medicine of the present invention, the best proportioning of wherein said active ingredient is:
Herba Artemisiae Scopariae 8.4%, Radix Scutellariae 8.3%, Talcum 16.7%, Fructus Aurantii Immaturus 8.3%, Folium Eriobotryae 8.3%, Radix Salviae Miltiorrhizae 11.1%, Herba Hedyotidis Diffusae 11.1%, Spica Prunellae 8.3%, Radix Paeoniae Rubra 8.3%, Radix Angelicae Sinensis 5.6%, Radix Glycyrrhizae 5.6%.
Active ingredient of the present invention is common water extract, and this water extract can adopt various common method for preparinies to obtain, and wherein a kind of simple and easy to do method is made up of following steps:
(1) by the proportioning weighting raw materials, add 8 times of water gagings at every turn and decoct 3 times, boil the back intense fire for the first time and fry in shallow oil 30min, boil the back intense fire for the second time and fry in shallow oil 1h, boil the back intense fire for the third time and fry in shallow oil 1.5h;
(2) collecting decoction filters the back and under 80 ℃, filtrating is concentrated into clear paste, puts in the baking oven in 75 ℃ and bakes dried cream, is ground into fine powder.
Active ingredient of the present invention adds an amount of medically acceptable excipient, can be made into conventional oral agents by conventional method, like granule or capsule.
Medicine of the present invention is a principal agent with Herba Artemisiae Scopariae and Radix Scutellariae, is equipped with Fructus Aurantii Immaturus, Talcum, Folium Eriobotryae, Herba Hedyotidis Diffusae, Spica Prunellae, Radix Paeoniae Rubra, Radix Angelicae Sinensis, Radix Glycyrrhizae and processes.In the described medicine, Herba Artemisiae Scopariae clearing away heat-damp and promoting diuresis, promoting the function of the gallbladder to alleviate jaundice; Radix Scutellariae heat clearing and damp drying, eliminating fire and detoxication, the two is combined into monarch drug, gathers clearing away damp-heat altogether, the effect of pathogenic fire purging poison; Fructus Aurantii Immaturus, Talcum are minister, strengthen rushing down clearly the damp and hot power of gastrointestinal; Assistant is with, Herba Hedyotidis Diffusae clearing heat and expelling damp toxin expelling, Spica Prunellae, Radix Paeoniae Rubra heat clearing away eliminating stagnation, and the Folium Eriobotryae making lung-QI pure and descending, the Radix Salviae Miltiorrhizae cooling blood and removing stasis, Radix Angelicae Sinensis replenishing vital QI with drugs of warm nature blood vessels, it is cold and cool to supervise its medicine; Make with Radix Glycyrrhizae heat-clearing and toxic substances removing, coordinating the actions of various ingredients in a prescription.The effect that all medicines are played the clearing heat and expelling damp removing heat from blood altogether.
Medicine of the present invention can observe further being confirmed through following clinical case to damp-heat accumulation type remedy of acne effect.
1. patient profile: we adopt this Drug therapy from year April in April, 2002 to 2004 to 108 routine damp-heat accumulation type patients with acne (being the surgery of Chinese medicine outpatient of Nanfang Hospital), and contrast treatment at random with tetracycline, spironolactone, vitamin B6 treatment group.Adopt the random table method to be divided into 4 groups (treatment is organized 3 groups, 1 group of matched group), every group 27 example at random.Wherein male 57 examples, women 41 examples; Minimum 15 years old of age, maximum 39 years old, average 23.8 years old; The course of disease is the shortest 1 month, and is the longest 10 years.Divide fraction by the state of an illness: slight 1 grade of 15 example, 2 grade of 11 example, 3 grade of 23 example; 4 grade of 30 example of moderate, 5 grade of 20 example, 6 grade of 9 example.Each organize the age through t check, sex through x
2Check, state of an illness classification are through a plurality of independent sample non parametric testss, and difference that there are no significant has comparability.
2. case is included standard in: (1) belongs to the damp-heat accumulation type person according to " Surgery of Chinese Medicine " typing standard, and disease is seen: skin greasing, pustule, tuberosity are arranged, or companion's halitosis; Indigestion and loss of appetite abdominal distention, constipation dark coloured urine, red tongue, yellow and greasy fur; Slippery and rapid pulse, or see the pustule cyst, the state of an illness is touching, and erythra is risen one after another etc.; (2) man, women volunteer; (3) get into not oral or other Retinoids, Retin-A, Renova, Accutane of external person in 2 weeks of test;
3. rejecting standard: (1) allergic constitution or to this medicine allergy sufferers; (2) be associated with serious primary disease such as cardiovascular, cerebrovascular, liver, kidney and hemopoietic system, psychotic; (3) occupational acne due to the chemical substance, drug-induced acne; (4) use other can influence the medicine person of the acne state of an illness and observation of curative effect simultaneously; (5) gestation or women breast-feeding their children; (6) while other Retinoids, Retin-A, Renova, Accutane of oral administration and externally person during the treatment fails to accomplish person's course of treatment.
4. Therapeutic Method: 1. treatment group gives the granule of following embodiment 1,2,3, each 1 bag, every day 2 times; 2. matched group oral tetracycline 250mg, every day 4 times; Spironolactone 20mg, vitamin B6 10mg, every day 3 times.Each organizes equal 4 weeks is 1 course of treatment, observes the statistics curative effect after 3 courses of treatment.
5. state of an illness classification and curative effect determinate standard: with reference to Chinese medical aesthstic with cosmetology branch beautifying skin group. acne vulgaris classification and criterion of therapeutical effect are tentatively formulated (the Chinese medical magazine of improving looks, 1998,4 (1): 41).
(1) grade scale (9 grades of classification method of 3 degree): calculate with a side surface part (a right or left side) acne, pimple, pustule number.Slightly: 1 grade is less than 25, and 2 grades 26～50,3 grades 51～75; Moderate: 4 grades 76～100,5 grades more than 100, and 6 grades with 1～2 tuberosity or cyst; Severe: 7 grades with 3～5 tuberositys or cyst, 8 grades with 6 with superior thyroid tubercle or cyst, 9 grades of tuberositys, cysts companion's hypertrophic cicatrix or sinus tracts.
(2) standards of grading: treat 9 grades of preceding 3 degree, per 1 grade is chosen as 1 fen; After the treatment, every reduction deducts 1 fen for 1 grade, if all disappearance then is 0 minute; Therapeutic index=(mark before treating-treatment back mark)/index * 100% before treating.If after the treatment still is simple, but alleviates to some extent, then can calculate little branch, every improvement 10% can deduct 0.1 fen.Skin lesion counting position selects the right side or left side facial, demarcates with centrage, comprises that half side forehead, cheekbone portion, buccal, chin portion and jaw portion summation calculate.The inactivity pathological changes comprises pigmentation, hole point-like cicatrix, ice pick appearance cicatrix, the index of not marking.
(3) criterion of therapeutical effect: be divided into 4 grades.Therapeutic index reaches and is clinical cure more than 95%; Therapeutic index 60%～95% is a produce effects; Therapeutic index 20%～59% is effective; Therapeutic index＜20% is invalid.
6. statistical procedures: adopt the SPSS10.0 statistical software, measurement data relatively adopts one way analysis of variance, and enumeration data relatively adopts a plurality of independent sample non parametric testss.
7. result:
Table 1 is respectively organized onset time and is compared (
unit: the sky)
* P＜0.05 of comparing with matched group.
Table 2 is respectively organized clinical efficacy relatively
Compare * P＜0.05, * * P＜0.01 with matched group.
With clinical cure, produce effects and effective and basic as the data of total effective rate calculating, it is 92.5% that 1 total effective rate is organized in treatment, and it is 85.2% that 2 total effective rates are organized in treatment; It is 81.5% that 3 total effective rates are organized in treatment; Matched group is 77.7%, compares with matched group, checks through Friedman; Treatment group 3 does not have significance with the matched group differences, and treatment group 1, treatment group 2 have significance with matched group difference.
8. untoward reaction: in taking the medicine process, the patient is if occur to feel sick, gastrointestinal reactions such as vomiting, stomachache, diarrhoea, and perhaps erythema and pimple are accompanied anaphylaxiss such as pruritus, and xerostomia, pharyngitis, angular cheilitis, glossitis etc. are the untoward reaction of drug-induced.During treating, it is slight nauseating that treatment group 1, treatment group 3 all have 1 routine patient to occur; Treatment group 2 has 2 routine patients the patient to occur to occur slight feeling sick; Matched group has 3 routine patients xerostomia to occur, and the symptom (seeing table 3) of feeling sick appears in 1 routine patient.
Table 3 is respectively organized the untoward reaction rate relatively
* * P＜0.01 of comparing with matched group.
9. recurrence situation: drug withdrawal was followed up a case by regular visits to after 2 months, treatment group 1 recurrence 3 examples, relapse rate 11.1%; Treatment group 2 recurrences 5 examples, relapse rate 18.5%; Treatment is organized 3 matched groups and is recurred 4 examples, relapse rate 14.8%, and matched group recurs 7 examples, relapse rate 25.9%.
Table 4 is respectively organized relapse rate relatively
* * P＜0.01 of comparing with matched group, * P＜0.05.
10. efficacy analysis: The above results shows that medicine of the present invention has good and clinical curative effect to the damp-heat accumulation type acne, and have untoward reaction little, be difficult for characteristics such as recurrence, can be used as the active drug of treating the damp-heat accumulation type acne.
The specific embodiment
Embodiment 1 (granule)
Take by weighing Herba Artemisiae Scopariae 750g, Radix Scutellariae 750g, Talcum 1500g, Fructus Aurantii Immaturus 750g, Folium Eriobotryae 750g, Radix Salviae Miltiorrhizae 1000g, Herba Hedyotidis Diffusae 1000g, Radix Paeoniae Rubra 750g, Spica Prunellae 750g, Radix Angelicae Sinensis 500g, Radix Glycyrrhizae 500g; Adding 8 times of water gagings decocts 3 times; Boil for the first time the back intense fire and fry in shallow oil 30min; Boil for the second time the back intense fire and fry in shallow oil 1h, boil the back intense fire for the third time and fry in shallow oil 1.5h.Collecting decoction then, filtering under back 80 ℃ filtrating is concentrated into relative density is 1.25 clear paste, puts in the baking oven in 75 ℃ and bakes dried cream, is ground into fine powder.In the dried cream fine powder that obtains, add an amount of dextrin and starch to 1000g, add water again and process granule, dry then, granulate are distributed into 10g/ bag (whenever comprising the about 3.5g of medicine dry powder).
Embodiment 2 (granule)
Take by weighing Herba Artemisiae Scopariae 1000g, Radix Scutellariae 1000g, Talcum 1700g, Fructus Aurantii Immaturus 1000g, Folium Eriobotryae 650g, Radix Salviae Miltiorrhizae 750g, Herba Hedyotidis Diffusae 750g, Radix Paeoniae Rubra 600g, Spica Prunellae 600g, Radix Angelicae Sinensis 400g, Radix Glycyrrhizae 400g; Adding 8 times of water gagings decocts 3 times; Boil for the first time the back intense fire and fry in shallow oil 30min; Boil for the second time the back intense fire and fry in shallow oil 1h, boil the back intense fire for the third time and fry in shallow oil 1.5h.Collecting decoction then, filtering under back 80 ℃ filtrating is concentrated into relative density is 1.25 clear paste, puts in the baking oven in 75 ℃ and bakes dried cream, is ground into fine powder.In the dried cream fine powder that obtains, add an amount of dextrin and starch to 1000g, add water again and process granule, dry then, granulate are distributed into 10g/ bag (whenever comprising the about 3.5g of medicine dry powder).
Embodiment 3 (granule)
Take by weighing Herba Artemisiae Scopariae 550g, Radix Scutellariae 550g, Talcum 1050g, Fructus Aurantii Immaturus 550g, Folium Eriobotryae 900g, Radix Salviae Miltiorrhizae 1250g, Herba Hedyotidis Diffusae 1250g, Radix Paeoniae Rubra 900g, Spica Prunellae 900g, Radix Angelicae Sinensis 600g, Radix Glycyrrhizae 600g; Adding 8 times of water gagings decocts 3 times; Boil for the first time the back intense fire and fry in shallow oil 30min; Boil for the second time the back intense fire and fry in shallow oil 1h, boil the back intense fire for the third time and fry in shallow oil 1.5h.Collecting decoction then, filtering under back 80 ℃ filtrating is concentrated into relative density is 1.25 clear paste, puts in the baking oven in 75 ℃ and bakes dried cream, is ground into fine powder.In the dried cream fine powder that obtains, add an amount of dextrin and starch to 1000g, add water again and process granule, dry then, granulate are distributed into 10g/ bag (whenever comprising the about 3.5g of medicine dry powder).
Embodiment 4 (capsule)
The drug particles that will be prepared into according to the method for embodiment 1, the gelatine capsule of packing into is processed capsule.
Claims (5)
1. medicine of treating the damp-heat accumulation type acne, this medicine is made up of active ingredient and medically acceptable excipient, it is characterized in that described active ingredient processed by following raw materials by weight percent medicine: Herba Artemisiae Scopariae 6～12%, Radix Scutellariae 6～12%; Talcum 11～20%, Fructus Aurantii Immaturus 6～12%, Folium Eriobotryae 7～10%; Radix Salviae Miltiorrhizae 8～14%, Herba Hedyotidis Diffusae 8～14%, Spica Prunellae 6～10%; Radix Paeoniae Rubra 6～10%, Radix Angelicae Sinensis 4～7%, Radix Glycyrrhizae 4～7%.
2. a kind of medicine of treating the damp-heat accumulation type acne according to claim 1 is characterized in that described active ingredient processed by following raw materials by weight percent medicine: Herba Artemisiae Scopariae 8～10%, Radix Scutellariae 8～10%; Talcum 14～18%, Fructus Aurantii Immaturus 8～10%, Folium Eriobotryae 8～9%; Radix Salviae Miltiorrhizae 10～12%, Herba Hedyotidis Diffusae 10～12%, Spica Prunellae 7～9%; Radix Paeoniae Rubra 7～9%, Radix Angelicae Sinensis 5～6%, Radix Glycyrrhizae 5～6%.
3. a kind of medicine of treating the damp-heat accumulation type acne according to claim 1 is characterized in that described active ingredient processed by following raw materials by weight percent medicine: Herba Artemisiae Scopariae 8.4%, Radix Scutellariae 8.3%; Talcum 16.7%, Fructus Aurantii Immaturus 8.3%, Folium Eriobotryae 8.3%; Radix Salviae Miltiorrhizae 11.1%, Herba Hedyotidis Diffusae 11.1%, Spica Prunellae 8.3%; Radix Paeoniae Rubra 8.3%, Radix Angelicae Sinensis 5.6%, Radix Glycyrrhizae 5.6%.
4. according to claim 1,2 or 3 described a kind of medicines of treating the damp-heat accumulation type acne, it is characterized in that described active ingredient is prepared by following method:
(1) by the proportioning weighting raw materials, add 8 times of water gagings at every turn and decoct 3 times, boil the back intense fire for the first time and fry in shallow oil 30min, boil the back intense fire for the second time and fry in shallow oil 1h, boil the back intense fire for the third time and fry in shallow oil 1.5h;
(2) collecting decoction filters the back and under 80 ℃, filtrating is concentrated into clear paste, puts in the baking oven in 75 ℃ and bakes dried cream, is ground into fine powder.
5. according to claim 1,2 or 3 described a kind of medicines of treating the damp-heat accumulation type acne, it is characterized in that described medicine is granule or capsule.
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| CN2011100455535A CN102114111B (en) | 2011-02-25 | 2011-02-25 | Medicament for treating damp-heat stagnation type acne |
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| CN1157160A (en) * | 1996-12-06 | 1997-08-20 | 王化石 | Chinese patent drug for curing acne |
| CN1063656C (en) * | 1998-02-12 | 2001-03-28 | 许家春 | Capsule of peenisetum flaccidum for treating acne and preparing method therefor |
| CN101224287B (en) * | 2007-12-27 | 2010-06-30 | 佟家勇 | Oral administration Chinese traditional medicine for treating acne and preparing method thereof |
| CN101869618B (en) * | 2010-06-03 | 2012-01-04 | 杨美伦 | Chinese medicinal acne-removal mixture for treating acne |
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