CN103636615B - Sterilizing composition containing tiadinil and application thereof - Google Patents
Sterilizing composition containing tiadinil and application thereof Download PDFInfo
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- CN103636615B CN103636615B CN201310664720.3A CN201310664720A CN103636615B CN 103636615 B CN103636615 B CN 103636615B CN 201310664720 A CN201310664720 A CN 201310664720A CN 103636615 B CN103636615 B CN 103636615B
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- tiadinil
- component
- bactericidal composition
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- 239000000203 mixture Substances 0.000 title claims abstract description 98
- VJQYLJSMBWXGDV-UHFFFAOYSA-N tiadinil Chemical compound N1=NSC(C(=O)NC=2C=C(Cl)C(C)=CC=2)=C1C VJQYLJSMBWXGDV-UHFFFAOYSA-N 0.000 title claims abstract description 67
- 230000001954 sterilising effect Effects 0.000 title claims abstract description 25
- 201000010099 disease Diseases 0.000 claims abstract description 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 8
- 230000000844 anti-bacterial effect Effects 0.000 claims description 22
- 238000004659 sterilization and disinfection Methods 0.000 claims description 21
- 206010039509 Scab Diseases 0.000 claims description 13
- -1 alkene oxime amine Chemical class 0.000 claims description 12
- 241000221785 Erysiphales Species 0.000 claims description 11
- 235000007164 Oryza sativa Nutrition 0.000 claims description 11
- 241000233679 Peronosporaceae Species 0.000 claims description 11
- 235000009566 rice Nutrition 0.000 claims description 11
- 240000008067 Cucumis sativus Species 0.000 claims description 10
- 241000209140 Triticum Species 0.000 claims description 10
- 235000021307 Triticum Nutrition 0.000 claims description 10
- 235000010799 Cucumis sativus var sativus Nutrition 0.000 claims description 9
- JHIPUJPTQJYEQK-ZLHHXESBSA-N orysastrobin Chemical compound CNC(=O)C(=N\OC)\C1=CC=CC=C1CO\N=C(/C)\C(=N\OC)\C(\C)=N\OC JHIPUJPTQJYEQK-ZLHHXESBSA-N 0.000 claims description 5
- 230000002708 enhancing effect Effects 0.000 claims description 3
- 244000241235 Citrullus lanatus Species 0.000 claims description 2
- 235000012828 Citrullus lanatus var citroides Nutrition 0.000 claims description 2
- 241000675108 Citrus tangerina Species 0.000 claims description 2
- 241000220225 Malus Species 0.000 claims description 2
- 235000011430 Malus pumila Nutrition 0.000 claims description 2
- 235000015103 Malus silvestris Nutrition 0.000 claims description 2
- 241000582441 Peronospora tabacina Species 0.000 claims description 2
- 241000220324 Pyrus Species 0.000 claims description 2
- 235000009754 Vitis X bourquina Nutrition 0.000 claims description 2
- 235000012333 Vitis X labruscana Nutrition 0.000 claims description 2
- 240000006365 Vitis vinifera Species 0.000 claims description 2
- 235000014787 Vitis vinifera Nutrition 0.000 claims description 2
- 241000607479 Yersinia pestis Species 0.000 claims description 2
- 239000000839 emulsion Substances 0.000 claims description 2
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 claims description 2
- 239000004530 micro-emulsion Substances 0.000 claims description 2
- 235000021017 pears Nutrition 0.000 claims description 2
- 239000000843 powder Substances 0.000 claims description 2
- 238000005507 spraying Methods 0.000 claims description 2
- 239000000375 suspending agent Substances 0.000 claims description 2
- 239000004562 water dispersible granule Substances 0.000 claims description 2
- 238000009736 wetting Methods 0.000 claims description 2
- 240000007594 Oryza sativa Species 0.000 claims 2
- 230000000694 effects Effects 0.000 abstract description 13
- 230000002195 synergetic effect Effects 0.000 abstract description 8
- 244000052769 pathogen Species 0.000 abstract description 5
- 230000001717 pathogenic effect Effects 0.000 abstract description 5
- 238000012271 agricultural production Methods 0.000 abstract description 2
- 230000003111 delayed effect Effects 0.000 abstract 1
- 230000006806 disease prevention Effects 0.000 abstract 1
- 230000003449 preventive effect Effects 0.000 description 22
- 241000894006 Bacteria Species 0.000 description 10
- 241000209094 Oryza Species 0.000 description 10
- 150000003851 azoles Chemical class 0.000 description 9
- 239000003814 drug Substances 0.000 description 9
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 8
- 239000002131 composite material Substances 0.000 description 7
- 238000012360 testing method Methods 0.000 description 7
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 6
- 150000001875 compounds Chemical class 0.000 description 6
- 150000002148 esters Chemical class 0.000 description 6
- 229920001542 oligosaccharide Polymers 0.000 description 6
- 150000002482 oligosaccharides Chemical class 0.000 description 6
- 239000007921 spray Substances 0.000 description 6
- OICGFSUWXCJLCO-UHFFFAOYSA-N 1-ethylsulfonylsulfanylethane Chemical compound CCSS(=O)(=O)CC OICGFSUWXCJLCO-UHFFFAOYSA-N 0.000 description 5
- PCCSBWNGDMYFCW-UHFFFAOYSA-N 5-methyl-5-(4-phenoxyphenyl)-3-(phenylamino)-1,3-oxazolidine-2,4-dione Chemical compound O=C1C(C)(C=2C=CC(OC=3C=CC=CC=3)=CC=2)OC(=O)N1NC1=CC=CC=C1 PCCSBWNGDMYFCW-UHFFFAOYSA-N 0.000 description 5
- 239000005772 Famoxadone Substances 0.000 description 5
- QNBTYORWCCMPQP-JXAWBTAJSA-N (Z)-dimethomorph Chemical compound C1=C(OC)C(OC)=CC=C1C(\C=1C=CC(Cl)=CC=1)=C/C(=O)N1CCOCC1 QNBTYORWCCMPQP-JXAWBTAJSA-N 0.000 description 4
- PXMNMQRDXWABCY-UHFFFAOYSA-N 1-(4-chlorophenyl)-4,4-dimethyl-3-(1H-1,2,4-triazol-1-ylmethyl)pentan-3-ol Chemical compound C1=NC=NN1CC(O)(C(C)(C)C)CCC1=CC=C(Cl)C=C1 PXMNMQRDXWABCY-UHFFFAOYSA-N 0.000 description 4
- SOUGWDPPRBKJEX-UHFFFAOYSA-N 3,5-dichloro-N-(1-chloro-3-methyl-2-oxopentan-3-yl)-4-methylbenzamide Chemical compound ClCC(=O)C(C)(CC)NC(=O)C1=CC(Cl)=C(C)C(Cl)=C1 SOUGWDPPRBKJEX-UHFFFAOYSA-N 0.000 description 4
- TWFZGCMQGLPBSX-UHFFFAOYSA-N Carbendazim Natural products C1=CC=C2NC(NC(=O)OC)=NC2=C1 TWFZGCMQGLPBSX-UHFFFAOYSA-N 0.000 description 4
- 239000005754 Cyazofamid Substances 0.000 description 4
- 239000005758 Cyprodinil Substances 0.000 description 4
- 239000005760 Difenoconazole Substances 0.000 description 4
- 239000005761 Dimethomorph Substances 0.000 description 4
- 239000005784 Fluoxastrobin Substances 0.000 description 4
- 239000005805 Mepanipyrim Substances 0.000 description 4
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 4
- 229930182764 Polyoxin Natural products 0.000 description 4
- 239000005820 Prochloraz Substances 0.000 description 4
- 239000005822 Propiconazole Substances 0.000 description 4
- 239000005869 Pyraclostrobin Substances 0.000 description 4
- 239000005864 Sulphur Substances 0.000 description 4
- 239000005839 Tebuconazole Substances 0.000 description 4
- 239000005863 Zoxamide Substances 0.000 description 4
- 239000011717 all-trans-retinol Substances 0.000 description 4
- 235000019169 all-trans-retinol Nutrition 0.000 description 4
- 239000006013 carbendazim Substances 0.000 description 4
- JNPZQRQPIHJYNM-UHFFFAOYSA-N carbendazim Chemical compound C1=C[CH]C2=NC(NC(=O)OC)=NC2=C1 JNPZQRQPIHJYNM-UHFFFAOYSA-N 0.000 description 4
- YXKMMRDKEKCERS-UHFFFAOYSA-N cyazofamid Chemical compound CN(C)S(=O)(=O)N1C(C#N)=NC(Cl)=C1C1=CC=C(C)C=C1 YXKMMRDKEKCERS-UHFFFAOYSA-N 0.000 description 4
- HAORKNGNJCEJBX-UHFFFAOYSA-N cyprodinil Chemical compound N=1C(C)=CC(C2CC2)=NC=1NC1=CC=CC=C1 HAORKNGNJCEJBX-UHFFFAOYSA-N 0.000 description 4
- BQYJATMQXGBDHF-UHFFFAOYSA-N difenoconazole Chemical compound O1C(C)COC1(C=1C(=CC(OC=2C=CC(Cl)=CC=2)=CC=1)Cl)CN1N=CN=C1 BQYJATMQXGBDHF-UHFFFAOYSA-N 0.000 description 4
- UFEODZBUAFNAEU-NLRVBDNBSA-N fluoxastrobin Chemical compound C=1C=CC=C(OC=2C(=C(OC=3C(=CC=CC=3)Cl)N=CN=2)F)C=1C(=N/OC)\C1=NOCCO1 UFEODZBUAFNAEU-NLRVBDNBSA-N 0.000 description 4
- FQKUGOMFVDPBIZ-UHFFFAOYSA-N flusilazole Chemical compound C=1C=C(F)C=CC=1[Si](C=1C=CC(F)=CC=1)(C)CN1C=NC=N1 FQKUGOMFVDPBIZ-UHFFFAOYSA-N 0.000 description 4
- FCOAHACKGGIURQ-UHFFFAOYSA-N iprobenfos Chemical compound CC(C)OP(=O)(OC(C)C)SCC1=CC=CC=C1 FCOAHACKGGIURQ-UHFFFAOYSA-N 0.000 description 4
- CIFWZNRJIBNXRE-UHFFFAOYSA-N mepanipyrim Chemical compound CC#CC1=CC(C)=NC(NC=2C=CC=CC=2)=N1 CIFWZNRJIBNXRE-UHFFFAOYSA-N 0.000 description 4
- 239000012452 mother liquor Substances 0.000 description 4
- 150000002825 nitriles Chemical class 0.000 description 4
- UWVQIROCRJWDKL-UHFFFAOYSA-N oxadixyl Chemical compound CC=1C=CC=C(C)C=1N(C(=O)COC)N1CCOC1=O UWVQIROCRJWDKL-UHFFFAOYSA-N 0.000 description 4
- 150000002923 oximes Chemical class 0.000 description 4
- YEBIHIICWDDQOL-YBHNRIQQSA-N polyoxin Polymers O[C@@H]1[C@H](O)[C@@H](C(C=O)N)O[C@H]1N1C(=O)NC(=O)C(C(O)=O)=C1 YEBIHIICWDDQOL-YBHNRIQQSA-N 0.000 description 4
- TVLSRXXIMLFWEO-UHFFFAOYSA-N prochloraz Chemical group C1=CN=CN1C(=O)N(CCC)CCOC1=C(Cl)C=C(Cl)C=C1Cl TVLSRXXIMLFWEO-UHFFFAOYSA-N 0.000 description 4
- STJLVHWMYQXCPB-UHFFFAOYSA-N propiconazole Chemical compound O1C(CCC)COC1(C=1C(=CC(Cl)=CC=1)Cl)CN1N=CN=C1 STJLVHWMYQXCPB-UHFFFAOYSA-N 0.000 description 4
- HZRSNVGNWUDEFX-UHFFFAOYSA-N pyraclostrobin Chemical compound COC(=O)N(OC)C1=CC=CC=C1COC1=NN(C=2C=CC(Cl)=CC=2)C=C1 HZRSNVGNWUDEFX-UHFFFAOYSA-N 0.000 description 4
- AMHNZOICSMBGDH-UHFFFAOYSA-L zineb Chemical compound [Zn+2].[S-]C(=S)NCCNC([S-])=S AMHNZOICSMBGDH-UHFFFAOYSA-L 0.000 description 4
- 241000196324 Embryophyta Species 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- 239000003899 bactericide agent Substances 0.000 description 3
- 230000000855 fungicidal effect Effects 0.000 description 3
- 238000011835 investigation Methods 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 238000001228 spectrum Methods 0.000 description 3
- NCVWJDISIZHFQS-CQSZACIVSA-N (-)-antofine Chemical compound C12=CC(OC)=C(OC)C=C2C2=CC(OC)=CC=C2C2=C1C[C@H]1CCCN1C2 NCVWJDISIZHFQS-CQSZACIVSA-N 0.000 description 2
- ZMYFCFLJBGAQRS-IRXDYDNUSA-N (2R,3S)-epoxiconazole Chemical compound C1=CC(F)=CC=C1[C@@]1(CN2N=CN=C2)[C@H](C=2C(=CC=CC=2)Cl)O1 ZMYFCFLJBGAQRS-IRXDYDNUSA-N 0.000 description 2
- LDVVMCZRFWMZSG-OLQVQODUSA-N (3ar,7as)-2-(trichloromethylsulfanyl)-3a,4,7,7a-tetrahydroisoindole-1,3-dione Chemical compound C1C=CC[C@H]2C(=O)N(SC(Cl)(Cl)Cl)C(=O)[C@H]21 LDVVMCZRFWMZSG-OLQVQODUSA-N 0.000 description 2
- PPDBOQMNKNNODG-NTEUORMPSA-N (5E)-5-(4-chlorobenzylidene)-2,2-dimethyl-1-(1,2,4-triazol-1-ylmethyl)cyclopentanol Chemical compound C1=NC=NN1CC1(O)C(C)(C)CC\C1=C/C1=CC=C(Cl)C=C1 PPDBOQMNKNNODG-NTEUORMPSA-N 0.000 description 2
- LQDARGUHUSPFNL-UHFFFAOYSA-N 1-[2-(2,4-dichlorophenyl)-3-(1,1,2,2-tetrafluoroethoxy)propyl]1,2,4-triazole Chemical compound C=1C=C(Cl)C=C(Cl)C=1C(COC(F)(F)C(F)F)CN1C=NC=N1 LQDARGUHUSPFNL-UHFFFAOYSA-N 0.000 description 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 2
- 239000005735 Benalaxyl-M Substances 0.000 description 2
- 239000005741 Bromuconazole Substances 0.000 description 2
- 239000005745 Captan Substances 0.000 description 2
- 239000005767 Epoxiconazole Substances 0.000 description 2
- 239000005774 Fenamidone Substances 0.000 description 2
- IWDQPCIQCXRBQP-UHFFFAOYSA-M Fenaminosulf Chemical compound [Na+].CN(C)C1=CC=C(N=NS([O-])(=O)=O)C=C1 IWDQPCIQCXRBQP-UHFFFAOYSA-M 0.000 description 2
- 239000005782 Fluopicolide Substances 0.000 description 2
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 description 2
- 239000005789 Folpet Substances 0.000 description 2
- 239000005868 Metconazole Substances 0.000 description 2
- 229910019142 PO4 Inorganic materials 0.000 description 2
- 239000005840 Tetraconazole Substances 0.000 description 2
- 239000005842 Thiophanate-methyl Substances 0.000 description 2
- 239000005846 Triadimenol Substances 0.000 description 2
- 239000005859 Triticonazole Substances 0.000 description 2
- FROZIYRKKUFAOC-UHFFFAOYSA-N amobam Chemical compound N.N.SC(=S)NCCNC(S)=S FROZIYRKKUFAOC-UHFFFAOYSA-N 0.000 description 2
- CJPQIRJHIZUAQP-MRXNPFEDSA-N benalaxyl-M Chemical compound CC=1C=CC=C(C)C=1N([C@H](C)C(=O)OC)C(=O)CC1=CC=CC=C1 CJPQIRJHIZUAQP-MRXNPFEDSA-N 0.000 description 2
- 230000000035 biogenic effect Effects 0.000 description 2
- 230000004071 biological effect Effects 0.000 description 2
- GAMFEMAXLMWCRG-UHFFFAOYSA-N bis(dimethylcarbamothioylsulfanyl)arsanyl n,n-dimethylcarbamodithioate Chemical compound CN(C)C(=S)S[As](SC(=S)N(C)C)SC(=S)N(C)C GAMFEMAXLMWCRG-UHFFFAOYSA-N 0.000 description 2
- HJJVPARKXDDIQD-UHFFFAOYSA-N bromuconazole Chemical compound ClC1=CC(Cl)=CC=C1C1(CN2N=CN=C2)OCC(Br)C1 HJJVPARKXDDIQD-UHFFFAOYSA-N 0.000 description 2
- 229940117949 captan Drugs 0.000 description 2
- CWVRPJSBNHNJSI-XQNSMLJCSA-N coumoxystrobin Chemical compound C1=C2OC(=O)C(CCCC)=C(C)C2=CC=C1OCC1=CC=CC=C1\C(=C/OC)C(=O)OC CWVRPJSBNHNJSI-XQNSMLJCSA-N 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
- AWZOLILCOUMRDG-UHFFFAOYSA-N edifenphos Chemical compound C=1C=CC=CC=1SP(=O)(OCC)SC1=CC=CC=C1 AWZOLILCOUMRDG-UHFFFAOYSA-N 0.000 description 2
- LMVPQMGRYSRMIW-KRWDZBQOSA-N fenamidone Chemical compound O=C([C@@](C)(N=C1SC)C=2C=CC=CC=2)N1NC1=CC=CC=C1 LMVPQMGRYSRMIW-KRWDZBQOSA-N 0.000 description 2
- GBOYJIHYACSLGN-UHFFFAOYSA-N fluopicolide Chemical compound ClC1=CC(C(F)(F)F)=CN=C1CNC(=O)C1=C(Cl)C=CC=C1Cl GBOYJIHYACSLGN-UHFFFAOYSA-N 0.000 description 2
- 239000011737 fluorine Substances 0.000 description 2
- 229910052731 fluorine Inorganic materials 0.000 description 2
- HKIOYBQGHSTUDB-UHFFFAOYSA-N folpet Chemical compound C1=CC=C2C(=O)N(SC(Cl)(Cl)Cl)C(=O)C2=C1 HKIOYBQGHSTUDB-UHFFFAOYSA-N 0.000 description 2
- 150000002460 imidazoles Chemical class 0.000 description 2
- 230000010534 mechanism of action Effects 0.000 description 2
- ZQEIXNIJLIKNTD-GFCCVEGCSA-N metalaxyl-M Chemical compound COCC(=O)N([C@H](C)C(=O)OC)C1=C(C)C=CC=C1C ZQEIXNIJLIKNTD-GFCCVEGCSA-N 0.000 description 2
- XWPZUHJBOLQNMN-UHFFFAOYSA-N metconazole Chemical compound C1=NC=NN1CC1(O)C(C)(C)CCC1CC1=CC=C(Cl)C=C1 XWPZUHJBOLQNMN-UHFFFAOYSA-N 0.000 description 2
- 239000003960 organic solvent Substances 0.000 description 2
- 150000002916 oxazoles Chemical class 0.000 description 2
- WBTYBAGIHOISOQ-UHFFFAOYSA-N pent-4-en-1-yl 2-[(2-furylmethyl)(imidazol-1-ylcarbonyl)amino]butanoate Chemical compound C1=CN=CN1C(=O)N(C(CC)C(=O)OCCCC=C)CC1=CC=CO1 WBTYBAGIHOISOQ-UHFFFAOYSA-N 0.000 description 2
- 235000021317 phosphate Nutrition 0.000 description 2
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 2
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 2
- 229920000053 polysorbate 80 Polymers 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 229910052717 sulfur Inorganic materials 0.000 description 2
- 239000011593 sulfur Substances 0.000 description 2
- QGHREAKMXXNCOA-UHFFFAOYSA-N thiophanate-methyl Chemical compound COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC QGHREAKMXXNCOA-UHFFFAOYSA-N 0.000 description 2
- BAZVSMNPJJMILC-UHFFFAOYSA-N triadimenol Chemical compound C1=NC=NN1C(C(O)C(C)(C)C)OC1=CC=C(Cl)C=C1 BAZVSMNPJJMILC-UHFFFAOYSA-N 0.000 description 2
- FFSJPOPLSWBGQY-UHFFFAOYSA-N triazol-4-one Chemical compound O=C1C=NN=N1 FFSJPOPLSWBGQY-UHFFFAOYSA-N 0.000 description 2
- 150000003852 triazoles Chemical class 0.000 description 2
- AMNAZJFEONUVTD-KEWDHRJRSA-N (2s,3s,4s,5r,6r)-6-(4-amino-2-oxopyrimidin-1-yl)-4,5-dihydroxy-3-[[(2s)-3-hydroxy-2-[[2-(methylamino)acetyl]amino]propanoyl]amino]oxane-2-carboxamide Chemical compound O1[C@H](C(N)=O)[C@@H](NC(=O)[C@H](CO)NC(=O)CNC)[C@H](O)[C@@H](O)[C@@H]1N1C(=O)N=C(N)C=C1 AMNAZJFEONUVTD-KEWDHRJRSA-N 0.000 description 1
- 241000233652 Chytridiomycota Species 0.000 description 1
- 239000005786 Flutolanil Substances 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- FEACDOXQOYCHKU-UHFFFAOYSA-N Gougerotin Natural products CNCC(=O)NC1=NC(=O)N(C=C1)C2OC(C(O)C(NC(=O)C(N)CO)C2O)C(=O)N FEACDOXQOYCHKU-UHFFFAOYSA-N 0.000 description 1
- 208000031888 Mycoses Diseases 0.000 description 1
- IWUCXVSUMQZMFG-AFCXAGJDSA-N Ribavirin Chemical compound N1=C(C(=O)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 IWUCXVSUMQZMFG-AFCXAGJDSA-N 0.000 description 1
- VMFXMTJCTSYHCF-HHQUSWFZSA-N [(2r,3r,4s,5r)-5-(hexylamino)-4-hydroxy-2-(hydroxymethyl)-6-[(7-hydroxy-4-oxo-1,3a,5,6,7,7a-hexahydroimidazo[4,5-c]pyridin-2-yl)amino]oxan-3-yl] carbamate Chemical compound CCCCCCN[C@@H]1[C@H](O)[C@@H](OC(N)=O)[C@@H](CO)OC1\N=C\1NC(C(=O)NCC2O)C2N/1 VMFXMTJCTSYHCF-HHQUSWFZSA-N 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- 229930008659 antofine Natural products 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- PTCGDEVVHUXTMP-UHFFFAOYSA-N flutolanil Chemical compound CC(C)OC1=CC=CC(NC(=O)C=2C(=CC=CC=2)C(F)(F)F)=C1 PTCGDEVVHUXTMP-UHFFFAOYSA-N 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 230000009545 invasion Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000003641 microbiacidal effect Effects 0.000 description 1
- 229940124561 microbicide Drugs 0.000 description 1
- 239000002855 microbicide agent Substances 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 239000000575 pesticide Substances 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- NCVWJDISIZHFQS-UHFFFAOYSA-N tylophorine B Natural products C12=CC(OC)=C(OC)C=C2C2=CC(OC)=CC=C2C2=C1CC1CCCN1C2 NCVWJDISIZHFQS-UHFFFAOYSA-N 0.000 description 1
- 230000017260 vegetative to reproductive phase transition of meristem Effects 0.000 description 1
- 229940100050 virazole Drugs 0.000 description 1
Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention relates to a sterilizing composition containing tiadinil. The composition comprises two active components A and B in synergetic effective quantity, wherein A is tiadinil and B is selected from one of methoxyl acrylic sterilizing components. The composition represents a good synergetic effect in a certain proportioning range, and the disease prevention effect of the composition is improved. The sterilizing composition can be used for preventing and treating various diseases on agricultural production, the number of use is reduced, the using cost is lowered, and generation of resistance to a single agent by pathogen is delayed.
Description
The application is the divisional application of " bactericidal composition containing tiadinil " application for a patent for invention, original application day: on January 17th, 2013, application number: 201310016327.3.
Technical field
The present invention relates to the bactericidal composition containing tiadinil, belong to bactericide field, composition is for preventing and treating rice blast, downy mildew, powdery mildew, anthracnose, late blight, leaf spot, scab etc.
Background technology
Tiadinil is the new type bactericide of amide containing structure, is a kind of New-type long-acting rice field bactericide, effectively can stops the invasion of pathogen, and have obvious induction of resistance.For Reasonable Protection medicament, delay germ to the drug-fast generation of new medicament and the control efficiency improving medicament, be necessary to carry out rational composition research.Disclose the microbicide compositions containing tiadinil and flutolanil in patent application 200810183486.1, its goal of the invention is the preparation of preparation containing active component, and clear and definite two kinds of active components can synergy for it.Except this is composite, in patent application, the processing method that tiadinil and virazole, Ningnanmycin, antofine etc. are mixed with interacting composition is described, but it does not illustrate that its objective is can the composition of synergy in order to obtain yet.So, also there is no the report about tiadinil and other sterilization component composition research at present.Inventor, by the research to the composite effect of tiadinil, has found some beyond thought effects.
Summary of the invention
The object of the present invention is to provide the bactericidal composition containing tiadinil, it is undertaken composite by the sterilization component of two kinds of different structures, the different mechanism of action, be expanding prevention spectrum and the effective way improving drug effect, the more important thing is and avoid or delay the generation of disease to new composition resistance.For realizing object of the present invention, inventor is composite with the compound with sterilization component by tiadinil, for preventing and treating the disease of crop.
The object of the invention is to be realized by following measures.
The invention provides a kind of bactericidal composition containing tiadinil, it is characterized in that said composition comprises A and B two kinds of active components of enhancing effective amount, wherein A is tiadinil, and B is selected from the one in a kind of or oxazole class sterilization component in a kind of, the imidazoles sterilization component in a kind of, the biogenic substances sterilization component in a kind of, the miazines sterilization component in a kind of, the amides compound in a kind of, the organic phosphates sterilization component in a kind of, the sulfur-bearing class sterilization component in a kind of, the triazole type sterilization component in methoxy acrylic sterilization component.
In above-mentioned bactericidal composition, methoxy acrylic sterilization component is selected from the one in Fluoxastrobin, oxime bacterium ester, pyraclostrobin, ZEN 90160, alkene oxime amine, orysastrobin, ZJ0712, SSF 126, SYP-3375, azoles bacterium ester, 2-cyano-3-amino-3-phenylancryic acetate.Triazole type sterilization component is selected from the one in propiconazole, Tebuconazole, Difenoconazole, nitrile bacterium azoles, Flusilazole, triazolone, bromuconazole, own azoles alcohol, metconazole, Triadimenol, epoxiconazole, tetraconazole, triticonazole, own azoles alcohol.Sulfur-bearing class sterilization component is selected from the one in zineb, Carbatene, tpn, sulphur, carbendazim, S-Ethyl ethylthio sulfonate, thiophanate-methyl, tmtd, asomate, captan, folpet, sulfonat, fenaminosulf, ambam.Organic phosphates sterilization component is selected from the one in iprobenfos, edifenphos.Amide-type sterilization component is selected from the one in dimethomorph, zoxamide, mefenoxam, benalaxyl-M, fluopicolide.Miazines sterilization component is selected from the one in the phonetic phenol of second, cyprodinil, fluorine mepanipyrim, mepanipyrim.Biogenic substances sterilization component is selected from the one in jinggangmeisu, kasugarnycin, polyoxin, oligosaccharides, Zhongshengmycin.Imidazoles sterilization component is selected from Prochloraz, cyazofamid, Fenamidone, pefurazoate a kind of.One in oxazole class sterilization component Xuan Zi famoxadone, Wakil.
Specifically, the invention provides a kind of bactericidal composition containing tiadinil, it is characterized in that: said composition comprises A and B two kinds of components of enhancing effective amount, and wherein A is tiadinil, and B is selected from Fluoxastrobin, oxime bacterium ester, pyraclostrobin, ZEN 90160, alkene oxime amine, orysastrobin, ZJ0712, SSF 126, SYP-3375, azoles bacterium ester, 2-cyano-3-amino-3-phenylancryic acetate, propiconazole, Tebuconazole, Difenoconazole, nitrile bacterium azoles, Flusilazole, triazolone, bromuconazole, own azoles alcohol, metconazole, Triadimenol, epoxiconazole, tetraconazole, triticonazole, zineb, Carbatene, tpn, sulphur, carbendazim, S-Ethyl ethylthio sulfonate, thiophanate-methyl, tmtd, asomate, captan, folpet, sulfonat, fenaminosulf, ambam, iprobenfos, edifenphos, dimethomorph, zoxamide, mefenoxam, benalaxyl-M, fluopicolide, the phonetic phenol of second, cyprodinil, fluorine mepanipyrim, mepanipyrim, jinggangmeisu, kasugarnycin, polyoxin, oligosaccharides, Prochloraz, cyazofamid, Fenamidone, pefurazoate, any one in famoxadone and Wakil.
Preferably, in above-mentioned bactericidal composition, component A is tiadinil, and B component is selected from the one in Fluoxastrobin, oxime bacterium ester, pyraclostrobin, ZEN 90160, alkene oxime amine, orysastrobin, propiconazole, Tebuconazole, Difenoconazole, nitrile bacterium azoles, Flusilazole, zineb, Carbatene, tpn, sulphur, carbendazim, S-Ethyl ethylthio sulfonate, iprobenfos, dimethomorph, zoxamide, the phonetic phenol of second, cyprodinil, jinggangmeisu, kasugarnycin, oligosaccharides, polyoxin, Prochloraz, cyazofamid, famoxadone, Wakil.
In above-mentioned bactericidal composition, preferably, the ratio of quality and the number of copies of A, B two between component is 1:50-50:1, and preferably, mass fraction is than being 1:20:5:1.
In above-mentioned bactericidal composition, preferably, the quality sum of component A and B component accounts for the 1-90% of bactericidal composition gross mass percentage.
Above-mentioned composition of the present invention can be made into suspending agent, wetting powder, water dispersible granules, aqua, microemulsion, aqueous emulsion, for spraying, fills with root, seed dressing etc.
The present invention also finds, above-mentioned bactericidal composition is when respective active component uses total amount to reduce, and have excellent control efficiency to rice blast, cucumber downy mildew, wheat powdery mildew, synergistic effect is obvious.
Present invention also offers above-mentioned composition for preventing and treating the purposes of crop pest, the disease of suitable control has the fungus-caused rice blast of Fungi Imperfecti, scab etc., the fungus-caused downy mildew of Mastigomycotina, late blight, peronospora tabacina etc., the fungus-caused powdery mildew of Ascomycotina, anthracnose, leaf spot etc., the rust that Basidiomycotina causes, smut etc.Therefore, the present invention also comprises the purposes of various agricultural fungal diseases on above-mentioned composition control crop.
In the purposes of above-mentioned composition of the present invention, described crop is preferably paddy rice, wheat, cucumber, watermelon, apple, grape, oranges and tangerines, pears, lichee, flowers etc.
Beneficial effect of the present invention is:
1, synergistic effect is obvious: composition shows good synergistic effect in certain ratio range, improves the protection effect of composition.
2, expanding prevention spectrum: composition can prevent and treat the multiple diseases in agricultural production.
3, use cost is reduced: because of composite, there is raising preventive effect, the increase of control spectrum, decrease access times, reduce use cost;
4, delay pesticide resistance: the composition of two kinds of different mechanism of action is composite, and pathogen not easily develops immunity to drugs, delay pathogen to the drug-fast generation of single dose.
Embodiment
Following examples further illustrate of the present invention, but the present invention is not confined to composition in present embodiment and purposes.
Embodiment 1 tiadinil composition is to the control efficiency of rice blast
Single compound or composition organic solvent dissolution are prepared into the mother liquor of 1000mg/L.According to biological activity determination trial test, a certain amount of above-mentioned mother liquor 0.1% Tween 80 is diluted, is mixed with the concentration of needs.During mensuration, first liquid medicine jet is imposed on pot rice plant, then inoculate pathogen, moisturizing is placed in greenhouse and cultivates, measure the percentage that plant leaf surface infects after certain hour after cultivating 24h.Use Abbot formula, convert percentage to preventive effect.
Theoretical preventive effect (%)=x+y-xy/100
The preventive effect of the active component A that x is working concentration when being a, the preventive effect of the active component B that y is working concentration when being b.Relatively theoretical effect and actual effect, evaluates the synergy of composition, for synergistic effect when being greater than theoretical preventive effect with actual preventive effect.The results are shown in Table 1.
Table 1 tiadinil composition is to the control efficiency of rice blast
By potted plant test, as seen from Table 1, the composition of the composition of the composition of the composition of the composition of the composition of the composition of the composition of the composition of tiadinil and Fluoxastrobin, tiadinil and oxime bacterium ester, tiadinil and propiconazole, tiadinil and Tebuconazole, tiadinil and S-Ethyl ethylthio sulfonate, tiadinil and iprobenfos, tiadinil and jinggangmeisu, tiadinil and kasugarnycin, tiadinil and oligosaccharides, tiadinil and Prochloraz composition to the effect of rice blast all higher than composition theoretical preventive effect.Obviously, tiadinil and the composite of above-mentioned Fungicidal compounds are synergy to rice blast.
Embodiment 2 tiadinil composition is to the control efficiency of cucumber downy mildew
Single compound or composition organic solvent dissolution are prepared into the mother liquor of 1000mg/L.According to biological activity determination trial test, a certain amount of above-mentioned mother liquor 0.1% Tween 80 is diluted, is mixed with the concentration of needs.During test, cucumber plant, substantially in 4 leaf phases, investigates downy mildew incidence before the 1st medicine.Carried out cucumber downy mildew pot experiment with tiadinil composition, and established corresponding single dose and blank, adopt the conventional conventional spray of manual sprayer, every medicament sprays 10 strains, and the 7-10d after 1 time that sprays sprays 1 time again.10-14d investigation after 2nd dispenser, whole blade is investigated in every strain, and record investigation total number of sheets, the sick number of sheets, calculate disease index and preventive effect according to following stage division.
Blade staging:
0 grade: anosis
1 grade: the scab area that is connected accounts for less than 1% of whole leaf area;
3 grades: the scab area that is connected accounts for the 1%-10% of whole leaf area;
5 grades: the scab area that is connected accounts for the 11%-20% of whole leaf area;
7 grades: the scab area that is connected accounts for the 21%-50% of whole leaf area;
9 grades: the scab area that is connected accounts for more than 51% of whole leaf area;
Theoretical preventive effect (%)=x+y-xy/100
The preventive effect of the active component A that x is working concentration when being a, the preventive effect of the active component B that y is working concentration when being b.Relatively theoretical effect and actual effect, evaluates the synergy of composition, for synergistic effect when being greater than theoretical preventive effect with actual preventive effect.The results are shown in Table 2.
Table 2 tiadinil composition is to the control efficiency of cucumber downy mildew
By tiadinil composition, the potted plant test of cucumber downy mildew is found, the composition of tiadinil and pyraclostrobin, the composition of tiadinil and ZEN 90160, the composition of tiadinil and Difenoconazole, the composition of tiadinil and zineb, the composition of tiadinil and Carbatene, the composition of tiadinil and tpn, the composition of tiadinil and S-Ethyl ethylthio sulfonate, the composition of tiadinil and dimethomorph, the composition of tiadinil and oligosaccharides, the composition of tiadinil and cyazofamid, tiadinil Yu the composition of famoxadone to the effect of cucumber downy mildew all higher than the theoretical preventive effect of correspondent composition.Obviously, the composition of tiadinil and above-mentioned Fungicidal compounds is synergy to cucumber downy mildew.
Embodiment three: tiadinil composition is to wheat powdery mildew field trial
Carried out wheat powdery mildew field trial with composition, and established corresponding single dose and blank, community 30m2 established by every medicament.Adopt the conventional conventional spray of knapsack sprayer, test respectively sprays 1 time in booting and flowering initial stage, 7 ~ 10d before medicine and after the 2nd dispenser, often process is by 5 samplings, often 50 strains, whole blade is investigated in every strain, and record investigation total number of sheets, the sick number of sheets, calculate disease index and preventive effect according to following stage division.
Blade staging:
0 grade: anosis
1 grade: the scab area that is connected accounts for less than 1% of whole leaf area;
3 grades: the scab area that is connected accounts for the 1%-5% of whole leaf area;
5 grades: the scab area that is connected accounts for the 6%-25% of whole leaf area;
7 grades: the scab area that is connected accounts for the 26%-50% of whole leaf area;
9 grades: the scab area that is connected accounts for more than 51% of whole leaf area;
Theoretical preventive effect (%)=x+y-xy/100
The preventive effect of the active component A that x is working concentration when being a, the preventive effect of the active component B that y is working concentration when being b.Relatively theoretical effect and actual effect, evaluates the synergy of composition, for synergistic effect when being greater than theoretical preventive effect with actual preventive effect.The control efficiency of bactericidal composition containing tiadinil to wheat powdery mildew the results are shown in Table 3.
The bactericidal composition of table 3 containing tiadinil is to wheat powdery mildew field efficacy
By tiadinil composition, wheat powdery mildew test is found, the composition of tiadinil and alkene oxime amine, the composition of tiadinil and orysastrobin, the composition of tiadinil and nitrile bacterium azoles, the composition of tiadinil and Flusilazole, the composition of tiadinil and sulphur, the composition of tiadinil and carbendazim, the composition of tiadinil and zoxamide, the composition of tiadinil and the phonetic phenol of second, the composition of tiadinil and cyprodinil, the composition of tiadinil and polyoxin, the composition of tiadinil and oligosaccharides, tiadinil is Yu the composition of famoxadone, the composition of tiadinil and Wakil to the effect of wheat powdery mildew all higher than the theoretical preventive effect of correspondent composition.Obviously, the composition of tiadinil and above-mentioned Fungicidal compounds is synergy to wheat powdery mildew.
Claims (5)
1. the bactericidal composition containing tiadinil, it is characterized in that said composition comprises A and B two kinds of active components of enhancing effective amount, wherein A is tiadinil, B is selected from the one in methoxy acrylic sterilization component alkene oxime amine, orysastrobin, and wherein the ratio of quality and the number of copies of A, B two between component is 3:5-3:1.
2. bactericidal composition according to claim 1, wherein the quality sum of component A and B component accounts for the 1-90% of bactericidal composition gross mass percentage.
3. the bactericidal composition described in any one of claim 1-2, said composition is made into suspending agent, wetting powder, water dispersible granules, aqua, microemulsion or aqueous emulsion, for spraying, fills with root or seed dressing.
4. bactericidal composition according to claim 3 is for preventing and treating the purposes of crop pest, and wherein disease is rice blast, scab, downy mildew, late blight, peronospora tabacina, powdery mildew, anthracnose, leaf spot, rust or smut.
5. purposes according to claim 4, wherein said crop is paddy rice, wheat, cucumber, watermelon, apple, grape, oranges and tangerines, pears, lichee or flowers.
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| CN101473829A (en) * | 2008-12-18 | 2009-07-08 | 孙家隆 | Bactericide agent composition containing tiadinil and flutolanil |
| CN101836631A (en) * | 2010-05-27 | 2010-09-22 | 浙江省桐庐汇丰生物化工有限公司 | SYP-1620-Jinggangmycin compound biocide |
| CN102630679A (en) * | 2012-04-05 | 2012-08-15 | 广西田园生化股份有限公司 | Pesticide composition containing orysastrobin |
| CN102669164A (en) * | 2012-05-30 | 2012-09-19 | 陕西上格之路生物科学有限公司 | Syp-1620 containing sterilization composition |
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| CN101473829A (en) * | 2008-12-18 | 2009-07-08 | 孙家隆 | Bactericide agent composition containing tiadinil and flutolanil |
| CN101836631A (en) * | 2010-05-27 | 2010-09-22 | 浙江省桐庐汇丰生物化工有限公司 | SYP-1620-Jinggangmycin compound biocide |
| CN102630679A (en) * | 2012-04-05 | 2012-08-15 | 广西田园生化股份有限公司 | Pesticide composition containing orysastrobin |
| CN102669164A (en) * | 2012-05-30 | 2012-09-19 | 陕西上格之路生物科学有限公司 | Syp-1620 containing sterilization composition |
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