CN103630524A - Intelligent type automatic qualitative and quantitative detection device and method for chemical substances - Google Patents

Intelligent type automatic qualitative and quantitative detection device and method for chemical substances Download PDF

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CN103630524A
CN103630524A CN201310471120.5A CN201310471120A CN103630524A CN 103630524 A CN103630524 A CN 103630524A CN 201310471120 A CN201310471120 A CN 201310471120A CN 103630524 A CN103630524 A CN 103630524A
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light
solvent
group
electronic installation
thing
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CN103630524B (en
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杨建夫
汪克毅
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Abstract

The invention provides an intelligent type automatic qualitative and quantitative detection device and method for chemical substances. The detection device comprises a container to be detected, a solvent treatment device, an extraction device, a pipeline, a concentration device, a detection unit and an electronic device. The detection method comprises the following steps: putting an object to be detected in the container to be detected; and detecting the chemical substances contained in the object to be detected in a rapid qualitative and quantitative manner through using the solvent treatment device, the extraction device, the concentration device, the detection unit and the electronic device. According to the intelligent type automatic qualitative and quantitative detection device and method for the chemical substances, the qualitative and quantitative effects of the object to be detected are realized; the rapid, simple and easy detection and a full-automatic and high-sensitivity detection function are achieved so that a user can rapidly detect the chemical substances contained in the object to be detected, and the quality control and the qualitative and quantitative effects on detection are achieved.

Description

Pick-up unit and the detection method of the chemical substance quantitative and qualitative analysis of intelligent robotization
Technical field
The present invention relates to a kind of pick-up unit and detection method of chemical substance quantitative and qualitative analysis of intelligent robotization, specifically, relate to a kind of short and high checkout equipment and the method for detection sensitivity of ease of Use and detection time.
Background technology
Food is the necessity that maintains physical function and metabolism, and it is normally consisted of carbohydrates, fat, protein or water.Food, except maintaining physical function, also can affect people's mood, for example, in some food, contain by the material that brings the joyful sense of people.Raising along with quality of life, work is also relative busy, cause people's pressure to become gradually large, therefore nowadays food concerning people not exclusively just pursuit have enough to eat and wear and with, the substitute is and enjoy happiness and the happy feeling that cuisines bring, therefore nowadays catering trade prosperity especially, various snack bars and drinks also emerge in an endless stream, and make people have more right to choose for food.
Science and technology is constantly progressive; also driven the prosperity of food processing industry simultaneously; in order to meet the demand in market; relevant industries can become the food with higher commercial value by natural food process; wherein may in food, add chemical substance; in addition, food can be convenient for people to preserve by packing conventionally, but the chemical substance in packing easily attaches on food.Yet, if eating too much chemical additive, people can affect physical function, cause and be eaten up with illness.Substantially, people, cannot be directly by being observed visually the chemical substance remaining on food when buying food, can only rely on the conscience of checking on industry of government.Still have unavoidably unsafe food peddles and is eaten by mistake by consumer on market, for example malicious milk melamine and plasticiser storm, some manufacturers are in order to pursue low cost, in legal food additives (mist generating agent), use cheap industrial plastics agent, the scope of its impact is very extensive, such as beverage, bread, cake medicine etc. even, if accidentally eat the food with plasticiser by mistake, not only cause reproductive system pathology, even there is carcinogenic danger.The poisonous additive event of food is constantly broken out as malicious milk event (melamine in China in Recent Years and Taiwan, plasticiser, clenbuterol hydrochloride), the carcinogenic soy sauce of monochloro propylene glycol, maleic acid Du Broad-rice-noodles bar, steroids (betamethasone), diuretics (hydrochlorothiazide), the pigeon feed additives such as cardiotonic (caffeine), Tianjin poison boiled dumpling event and the not yet Environmental Hormone of outburst, aquaculture, electric consumers, toy, commodity, cosmetics, agricultural product, etc., people common people's uneasiness and the attention to Food Inspection have been caused, thereby the panic thorough check consciousness of arousing Liao Ge manufacturer of panic buying milk tide, add crops use in a large number agricultural chemicals ，Nong political affairs unit to agricultural product containing Pesticides Testing control pay attention to day by day, aquaculture feed is toxic again and again, cause outlet to be obstructed, rivers and creeks, various countries ecology is subject to polluting and destroys, the more urgent strict reason of implementing check etc. of environmental monitoring control, fast and convenient detecting instrument is the comprehensive purposes that proceeds to industrial community production control, and check sensitivity require more and more will be toward the future development of the needs of trace and reliability.
In addition, nowadays sick edible medicine is all current on market widely with the health food of safeguarding physiological function, and before each similar drug circulates on market, strict detection can be first carried out in pharmaceutical factory, to check the composition of medicine whether correct, carries out last checking on.
In daily life, consumer often faces the puzzlement of having bought fake products, fake wine, government and the manufacturer difficulty of checking on, and consumer has the needs that detect voluntarily.
The general technology of knowing is to check the composition in food and medicine with gas chromatography mass spectrometer (GC) or high performance liquid chromatography (HPLC), wherein the shortcoming of gas chromatography mass spectrometer (GC) is need to lose time to increase the volatility of analyte, and then cause the interference in analytic process and increase quantitative degree of difficulty, high performance liquid chromatography (HPLC) is to utilize chemistry in preparation process or the interactional difference of physical property to carry out separating mixture.While using high performance liquid chromatography, liquid thing to be detected is injected into chromatographic column at one time, be mainly according to various things to be detected during by chromatographic column mutually moving and fixedly the difference of the residence time that gap causes of the interaction strength of phase reach separating effect, finally by detecting device, the resulting signal of the induction of each material is detected to contained material, its analysis time, long (general about more than one, two week) and flow process were loaded down with trivial details like this.And high performance liquid chromatography is by detecting device for example UV-detector character that cannot identification sample.In addition, high performance liquid chromatography (HPLC) equipment and required consumables are expensive, a large amount of poisonous organic solvent waste material of producing to physical environment can cause very large harm, operation is strict, method exploitation is remarkable and time-consuming.Therefore, above-mentioned two kinds of equipment need to be subject to the training of operating machines and have the people of application experience should be used for checking rapidly the composition of food and medicine, for pharmaceutical factory, because above-mentioned disappearance also causes pharmaceutical production high expensive.
In order to overcome above-mentioned defect, the inventor drops into the much time and carries out correlative study, and add more every quality, carry out the research and development of Related product, thereby release the present invention [pick-up unit and the detection method of the chemical substance quantitative and qualitative analysis of intelligent robotization.
Summary of the invention
In order to overcome the defect of prior art, fundamental purpose of the present invention is to provide a kind of ease of Use, reach the composition of poisonous chemical solvent in quick (0.1 second was by several minutes) and large component analysis determinand, promote sensitivity and the accuracy of analyzing and testing, wherein determinand is medicine, pharmaceutical raw material, food, food pollution, Environmental Hormone, explosive, virus, cancer biological marker, true and false article identification, the identification of true wine fake wine etc., and can promote sensitivity and the accuracy of analyzing and testing.
To achieve these goals and effect, the invention provides a kind of the first embodiment of pick-up unit of chemical substance quantitative and qualitative analysis of intelligent robotization, described pick-up unit Bao Kuo ︰ mono-testing container, for storing thing to be detected, one solvent treating apparatus, for storage, heating and pressurized solvent, one extraction equipment, described extraction equipment comprises an extraction board, one perforation group, one switch member, one weight measurement unit and an extraction dropper, described extraction board is provided with a positioning part, and in described extraction board, be provided with a sense channel being connected with described positioning part, described perforation group activity group is located in described sense channel, described perforation group clips and pierces through described testing container, described switch member is hubbed on described extraction equipment, and with the setting of described perforation group interlock, described weight measurement unit is corresponding with described positioning part, and group is located at described sense channel, described extraction dropper group is located at the end of described extraction board, and be connected with described sense channel, described extraction dropper is provided with a titration end, described solvent is mixed to form extract via described extraction board and described thing to be detected, a weight information is exported in described weight measurement unit, one pipeline, the described sense channel of solvent treating apparatus and described extraction equipment described in described pipeline connection, one enrichment facility, described enrichment facility comprises a mobile platform and a collection container, described mobile platform is provided with a heating part, and described collection container is placed on described heating part, and by heating and extract mode that dropper blows by extract simmer down to concentrate, one detecting unit, described detecting unit comprises that a sampler, a smooth focus control group and detect slide glass, described detection slide glass group is located on described mobile platform, the end face of described detection slide glass is provided with a joint portion, the molecule of described joint portion in described concentrate is combined, and after described smooth focus control group throw light, reads a Raman spectrum signal, one electronic installation, described electronic installation and described solvent treating apparatus, described extraction equipment, described enrichment facility, described detecting unit electrically connect, described electronic installation receives described Raman spectrum signal and analyzes contained chemical substance in described detection thing, and described electronic installation receives described weight information simultaneously.
Thus, after the molecule of described concentrate is combined with described detection slide glass, by described smooth focus control group, reading the highest Raman spectrum signal provides weight information to described electronic installation by described weight measurement unit, described electronic installation carries out after the weight information of thing to be detected and the compare of analysis of Raman spectrum signal, reconfigure the chemical substance of thing to be detected, reach like this effect of quantitative and qualitative analysis thing to be detected, provide fast and easily and operate, full-automatic and highly sensitive measuring ability, allow user can detect fast the chemical substance that described thing to be detected comprises, and reach QC and detect qualitative and quantitative effect.
Preferably, the first embodiment of the present invention also comprises following technical characterictic, described solvent treating apparatus comprises the reservoir of a storage of solvent, the heating chamber of one heated solvent, two solenoid valves and a force (forcing) pump being connected with heating chamber, described pipeline comprises a front pipeline and a rear pipeline, reservoir and described heating chamber described in described front pipeline connection, heating chamber and described sense channel described in described rear pipeline connection, described two solenoid valves respectively group are located on described front pipeline and described rear pipeline, by two solenoid valves, adjusting described reservoir and described heating chamber and described heating chamber and described sense channel is conducting state or hinders but state, described force (forcing) pump is as the effect that pushes described solvent.More preferably, the further technical characterictic of the first embodiment of the present invention, described in this, perforation group comprises two needle tubing sheets that are oppositely arranged, the shape of each needle tubing sheet is corresponding with the structure of described testing container, described in each, one end mask of needle tubing sheet has a plurality of needle tubings, when two needle tubing sheets clip the both sides of described testing container, described in each, a plurality of needle tubings of needle tubing sheet can penetrate in described testing container.
More preferably, the first embodiment of the present invention also comprises following technical characterictic, the described joint portion of described detection slide glass is surface reinforced Raman active carrier (SERS-active substrate), the colloidal sol body that described surface reinforced Raman active carrier is metallic particles, the surface of described joint portion is provided with a Raman spectrum optically focused focus sheet, described Raman spectrum optically focused focus sheet is silicon chip or other Raman unit spectrum standard specimen, supply the application of optically focused focusing, and be provided with a concentrate limit collar (Retaining Ring) in described joint portion periphery, the material of described concentrate limit collar is paraffin ring or Te Folong (Teflon), with restriction concentrate, drip to and detect the scope of slide glass and homogeneity and the reliability that keeps concentrate to distribute.
Preferably, described smooth focus control group comprises a light supply apparatus and a spectrometer, described light supply apparatus can project laser light, ultraviolet light (UV), near infrared light (Near Infra red:NIR), far red light (Far Infra red:FIR) or visible ray, described light supply apparatus comprises a body, one light emitting source, one goes out shaven head, one group of described focus regulating mechanism that goes out shaven head described in being located at, described light emitting source group is located at described intrinsic one end, described light emitting source projects the light of at least one wavelength, and produce at least one projecting light path and at least one backhaul light path, describedly go out the bare headed group of other end that is located at described body, it is described that to go out shaven head corresponding with described detection slide glass, described at least one projecting light path finally goes out shaven head to the described joint portion of described detection slide glass by described by one first collimation lens, a laser rays filtrator, a colo(u)r filter, a beam splitter in order, described projecting light path arrives one first focusing light path of described detection slide glass by described beam splitter in described beam splitter generation one, by the second focusing light path of described beam splitter reflection, described the second focusing light path projects by one second focus lamp to one group of photosensory assembly that is located at described body with one, the described joint portion of detecting slide glass described at least one return light route in order through described in go out shaven head, described colo(u)r filter, a reflector plate, one second collimation lens and one group of long pass light filter that is located at described inner body wall, described long pass light filter and the electric connection of described spectrometer, described focus regulating mechanism, described photosensory assembly and described spectrometer and described electronic installation are electrically connected, the difference of the path of described electronic installation comparison the first focusing light path and the path of the second focusing light path, by going out the burnt section of shaven head and described detection slide glass described in the adjustment of described focal length automatic mechanism, goes out bare headed focal length described in adjusting.
More preferably, the technical characterictic of the first embodiment of the present invention also comprises a light focus control device being electrically connected with light emitting source, described light emitting source is provided with at least two luminescent grains, luminance and the emission wavelength of the arbitrary described luminescent grain of described smooth focus control device regulation and control, make described light emitting source project the light of at least one wavelength, and control wavelength, power, light intensity and the shinny state of luminescent grain.
More preferably, the first embodiment of the present invention also comprises technical characterictic, described electronic installation comprises a data storage element, one receiving element and a processing unit, described data storage element and described receiving element and the mutual data transmission of described processing unit, described data storage element stores a plurality of example weight information, a plurality of sample Raman spectral information and a plurality of sample scattering strength values, described processing unit is by the weight information of thing to be identified thus, the relativeness of Raman spectral information and scattering strength numerical value, minimal square error method (Least Square Method) and the completely data analysis of restrictive condition minimal square error method (Full Constrained Least Square Method), compare a plurality of example weight information in described data storage element, a plurality of sample Raman spectral information and a plurality of sample scattering strength values are carried out baseline correction, subtracting each other of fluorescence spectrum, and data qualitative and quantitative analysis detects the contained chemical substance of thing.
Preferably, the first embodiment of the present invention also comprises following technical characterictic, and described mobile platform comprises a plurality of displacement motors, and described a plurality of displacement motors provide the multidirectional displacement of described mobile platform and rotation; Preferably, described sampler comprises a plurality of mobile motors and a sampler, described mobile motor provides the multidirectional displacement of described sampler and rotation, and described sampler is quantitative pin (Syringe), quantitative liquid suction pipe (Pipette) or electronic automatic ration aspirator (Motorized Auto-Pipette).
Preferably, the first embodiment of the detection method of the chemical substance quantitative and qualitative analysis of a kind of intelligent robotization of the present invention, described detection method Bao draws together Xia row Bu Zhou ︰ Yang product Dings Wei ︰ the described testing container that is equipped with determinand is put into described extraction equipment, described determinand is positioned on described weight measurement unit, and by described weight measurement unit, produce weight information, then operate described switch member and described perforation group is clipped and partly penetrate described testing container; Rong Ji Chu Li ︰ is by the described solvent heating (10 ℃ to 200 ℃) in described solvent treating apparatus and pressurization (0.1kg/cm 2to 1000kg/cm 2) and be transported to described extraction equipment; Extraction is got described in ︰ solvent and is flow into and in described testing container, mix with described determinand and produce an extract, and described extraction dropper splashes into the described extract of collection in described collection container; Thereby the described solvent in Nong Suo ︰ heating and the described acceleration collection container of blowing is waved to send out and is obtained concentrate; Described in Fen Xi ︰, sampler is drawn described concentrate, and be added drop-wise on described detection slide glass and be combined after blow dried with described joint portion, after irradiating with described smooth focus control group, read Raman spectrum signal, and being input to described electronic installation analyzes, described electronic installation analyses and comparison Raman spectrum signal and weight information, analyze chemical substance contained in thing to be detected.
Preferably, the first embodiment of the detection method of the chemical substance quantitative and qualitative analysis of a kind of intelligent robotization of the present invention also comprises following technical characterictic, in described analytical procedure, described electronic installation is by the Raman spectrum signal of described thing to be detected, weight information be stored in a plurality of sample Raman spectrum signals in described electronic installation, a plurality of example weight information is compared, baseline correction, subtracting each other of fluorescence spectrum, data qualitative and quantitative analysis, application minimal square error method (Least Square Method) and the completely data of restrictive condition minimal square error method (Full Constrained Least Square Method) are analyzed the contained chemical substance of thing to be detected.
Preferably, the first embodiment of the present invention is technical characterictic also, described smooth focus control group is radiated the first light and the second light, the wavelength of described the first light and described the second light is close, while scanning the described thing to be detected of detection with this, produce the first spectrogram and the second spectrogram, fluorescence spectrum subtracts each other the quantitative and qualitative analysis result that obtains detecting dark sample with baseline correction thus, or described smooth focus control group is radiated a far red light, while scanning detection thing to be detected with this, thereby generation does not contain the Raman spectrogram of the noise of fluorescence reaches the quantitative and qualitative analysis result that can detect dark sample.
Preferably, the further technical characterictic of the first embodiment of the present invention, in solvent treatment step, a force (forcing) pump pushes heated solvent from described solvent treating apparatus to described extraction equipment, and described force (forcing) pump produces 0.1kg/cm 2～1000kg/cm 2the pressure of scope.Preferably, described solvent is organic solvent, hydrosolvent, mixed solvent or carbon dioxide.
Preferably, the second embodiment of the pick-up unit of the chemical substance quantitative and qualitative analysis of intelligent robotization of the present invention, described pick-up unit Bao Kuo ︰ mono-testing container, for storing thing to be detected, one solvent treating apparatus, for store and heat pressurization described solvent, one extraction equipment, described extraction equipment comprises an extraction board, one perforation group, one switch member and a weight measurement unit, described extraction board is provided with a positioning part, described extraction board is provided with a sense channel being connected with positioning part and an endpiece being connected with described sense channel, described perforation group activity group is located in described sense channel, described perforation group clips and pierces through described testing container, described switch member is hubbed on described extraction board, and with the setting of described perforation group interlock, described weight measurement unit is corresponding with described positioning part, and group is located at described sense channel, described endpiece is connected with described sense channel, the described solvent having heated imports in described sense channel from described pipeline, and dissolve the deposits yields extract described to be detected in described testing container through described perforation group, a weight information is exported in described weight measurement unit, one pipeline, the sense channel of solvent treating apparatus and described extraction equipment described in described pipeline connection, one test tubes, described test tubes group is located at described endpiece and is connected with described sense channel, and in described test tubes, around a joint portion is set, described extract passes into described test tubes and is combined with described joint portion, one detecting unit, described detecting unit comprises a smooth focus control group, described smooth focus control group throw light reads setting and the detection thing Raman spectrum signal that a Raman spectrum signal is done peak signal focal length behind described joint portion, one electronic installation, described electronic installation and described solvent treating apparatus, described extraction equipment, described detecting unit electrically connect, described electronic installation receives described Raman spectrum signal, and analyze described Raman spectrum signal, obtain chemical substance information contained in described detection thing, described electronic installation receives described weight information.
Thus, by described solvent treating apparatus and described extraction equipment, obtain concentrate, and after being combined by the molecule of concentrate and the described joint portion of described test tubes, by described smooth focus control group, read weight information that Raman spectrum signal and weight measurement unit provide to described electronic installation, described electronic installation is compared and is analyzed by analytic unit after the described weight information and Raman spectrum signal of thing to be detected, reconfigure the chemical substance of thing to be detected, reach the effect of quantitative and qualitative analysis thing to be detected, provide fast and easily and operate, full-automatic and highly sensitive measuring ability, allow user can detect fast the chemical substance that thing to be detected comprises, and reach the effect of QC and detection.
Preferably, the second embodiment of the pick-up unit of the chemical substance quantitative and qualitative analysis of intelligent robotization of the present invention also comprises following technical characterictic, described solvent treating apparatus comprises a force (forcing) pump, one reservoir, one heating chamber being connected with described reservoir and described sense channel, described pipeline comprises one first pipeline and one second pipeline, described the first pipeline connection force (forcing) pump and described sense channel, reservoir and described sense channel described in described the second pipeline connection, and on described the first pipeline, be provided with one first valve, on described the second pipeline, be provided with one second valve.
Preferably, the second embodiment of the pick-up unit of the chemical substance quantitative and qualitative analysis of intelligent robotization of the present invention also comprises following technical characterictic, described perforation group comprises two needle tubing sheets that are oppositely arranged, the shape of each needle tubing sheet is corresponding with the structure of described testing container, one end mask of each needle tubing sheet has a plurality of needle tubings, when two needle tubing sheets clip the both sides of described testing container, a plurality of needle tubings of each needle tubing sheet can penetrate in testing container.
Preferably, the second embodiment of the pick-up unit of the chemical substance quantitative and qualitative analysis of intelligent robotization of the present invention also comprises following technical characterictic, the described joint portion of described test tubes is surface reinforced Raman active carrier (SERS-active substrate), the colloidal sol body that described surface reinforced Raman active carrier is metallic particles.
Preferably, the second embodiment of the pick-up unit of the chemical substance quantitative and qualitative analysis of intelligent robotization of the present invention also comprises following technical characterictic, described smooth focus control group comprises a light supply apparatus and a spectrometer, described light supply apparatus can project laser light, ultraviolet light (UV), near infrared light (Near Infra red:NIR), far red light (Far Infra red:FIR) or visible ray, described light supply apparatus comprises a body, one light emitting source, one goes out shaven head, one group goes out bare headed focus regulating mechanism described in being located at, described light emitting source group is located at described intrinsic one end, described light emitting source projects the light of at least one wavelength, and produce at least one projecting light path and at least one backhaul light path, describedly go out the bare headed group of other end that is located at described body, it is described that to go out shaven head corresponding with the described joint portion of described test tubes, described at least one projecting light path finally goes out shaven head to the described joint portion of described test tubes by described through one first collimation lens, a laser rays filtrator, a colo(u)r filter, a beam splitter in order, at least one projecting light path arrives one first focusing light path of the described joint portion of described test tubes by described beam splitter in described beam splitter generation one, by the second focusing light path of described beam splitter reflection, described the second focusing light path projects by one second focus lamp to one group of photosensory assembly that is located at described body with one, described in described at least one return light route the described joint portion of test tubes in order through described in go out shaven head, described colo(u)r filter, a reflector plate, one second collimation lens and one group of long pass light filter that is located at described inner body wall, the electric connection of described long pass light filter and described spectrometer, described focus regulating mechanism, described photosensory assembly and described spectrometer and described electronic installation are electrically connected, the difference of the path of described electronic installation comparison the first focusing light path and the path of the second focusing light path, automatically described in adjusting by described focus regulating mechanism, go out bare headed burnt section, to go out the focal length of shaven head and the described joint portion of described test tubes described in adjusting.
Preferably, the second embodiment of the pick-up unit of the chemical substance quantitative and qualitative analysis of intelligent robotization of the present invention also comprises following technical characterictic, described pick-up unit also comprises a light focus control device being electrically connected with described light emitting source, described light emitting source is provided with at least two luminescent grains, luminance and the emission wavelength of the arbitrary described luminescent grain of described smooth focus control device regulation and control, make described light emitting source project the light of at least one wavelength, and control wavelength, power, light intensity and the shinny state of luminescent grain.Preferably, described smooth focus control group is provided with a rotation motor, and described rotation motor drives described light supply apparatus displacement.
Preferably, the second embodiment of the detection method of the chemical substance quantitative and qualitative analysis of intelligent robotization of the present invention, described detection method Bao draws together Xia row Bu Zhou ︰ Yang product Dings Wei ︰ the testing container that determinand is housed is put into extraction equipment, and then operating switch part makes perforation group clip described testing container and part penetrates described testing container; Rong Ji Chu Li ︰ is by the solvent heating in solvent treating apparatus and be pressed and delivered to extraction equipment; Extraction is got ︰ solvent and is flow into interior generation one extract that mixes with determinand of described testing container; Described in Fen Xi ︰, extract is delivered to test tubes by endpiece, molecule in described extract is combined with described joint portion, after heating and blow dried, by light focus control group, read a Raman spectrum signal, and be input to electronic installation analysis, described electronic installation comparison Raman spectrum signal and weight information are analyzed chemical substance contained in thing to be detected.
Preferably, the second embodiment of the method for the pick-up unit of the chemical substance quantitative and qualitative analysis of intelligent robotization of the present invention also comprises that following Ji art Te Zheng ︰ is in analytical procedure, described electronic installation is by the Raman spectrum signal of described thing to be detected, weight information and a plurality of sample Raman spectrum signals that are stored in described electronic installation, a plurality of example weight information is compared, baseline correction, subtracting each other of fluorescence spectrum, data qualitative and quantitative analysis, application minimal square error method (Least Square Method) and the completely data of restrictive condition minimal square error method (Full Constrained Least Square Method) are analyzed the contained chemical substance of described thing to be detected.
Preferably, the second embodiment of the method for the pick-up unit of the chemical substance quantitative and qualitative analysis of intelligent robotization of the present invention, described smooth focus control group is radiated the first light and the second light, the wavelength of described the first light and described the second light is close, while scanning the described thing to be detected of detection with this, produce the first spectrogram and the second spectrogram, by subtract each other the quantitative and qualitative analysis result that obtains detecting dark sample with baseline correction with this fluorescence spectrum, or described smooth focus control group is radiated a far red light, while scanning detection thing to be detected with this, thereby generation does not contain the Raman spectrogram of the noise of fluorescence reaches the quantitative and qualitative analysis result that can detect dark sample.
Preferably, the method for the pick-up unit of the chemical substance quantitative and qualitative analysis of intelligent robotization of the present invention, in Sample location step, the weight data of determinand is measured in described electronic installation in described weight measurement unit.
Preferably, the method for the pick-up unit of the chemical substance quantitative and qualitative analysis of intelligent robotization of the present invention, in solvent treatment step, opens the second valve and makes the solvent in reservoir be sent to heating chamber heating (10 ℃ to 200 ℃).Preferably, described solvent is organic solvent, water, mixed solvent or carbon dioxide.
Preferably, the method of the pick-up unit of the chemical substance quantitative and qualitative analysis of intelligent robotization of the present invention, in extraction step, opens the first valve the gas in force (forcing) pump is flow in described sense channel, and push solvent in described testing container, finally in described test tubes.The air pressure of the gas that preferably, described force (forcing) pump is sent is 0.1kg/cm 2～1000kg/cm 2.
Preferably, the 3rd embodiment of the pick-up unit of the chemical substance quantitative and qualitative analysis of intelligent robotization of the present invention, described pick-up unit Bao Kuo ︰ mono-testing container, for storing thing to be detected, one solvent treating apparatus, for storage, heating and pressurized solvent, one extraction equipment, described extraction equipment comprises an extraction board, one perforation group, one switch member, one weight measurement unit and an extraction dropper, described extraction board is provided with a positioning part, and in described extraction board, be provided with a sense channel being connected with described positioning part, described perforation group activity group is located in described sense channel, described switch member and the setting of described perforation group interlock, described weight measurement unit is corresponding with described positioning part, and group is located at described sense channel, described extraction dropper group is located at the end of described extraction board and is connected with sense channel, described extraction dropper is provided with a titration end, described solvent is mixed to form extract via described extraction equipment and described thing to be detected, a weight information is exported in described weight measurement unit, one pipeline, the sense channel of solvent treating apparatus and described extraction equipment described in described pipeline connection, one enrichment facility, described enrichment facility comprises a mobile platform and an inspection instrument, described mobile platform is provided with a heating part, described inspection instrument is seated in described heating part, in described inspection instrument, there is a joint portion, described extract is in described inspection instrument, and through heating and air blowing simmer down to concentrate, the molecule in described concentrate is combined with described joint portion, one detecting unit, described detecting unit comprises a smooth focus control group, described smooth focus control group comprises a light supply apparatus, described light supply apparatus one end is provided with one and goes out shaven head, describedly go out shaven head and wear described mobile platform and corresponding with the joint portion of inspection instrument, described smooth focus control group throw light reads a Raman spectrum signal behind joint portion, one electronic installation, described electronic installation and described solvent treating apparatus, described extraction equipment, described enrichment facility, described detecting unit electrically connect, described electronic installation receives Raman spectrum signal and carrys out chemical substance contained in analyzing and testing thing, and simultaneously described electronic installation receives weight information.
Preferably, the 3rd embodiment of the pick-up unit of the chemical substance quantitative and qualitative analysis of intelligent robotization of the present invention also comprises following technical characterictic, described solvent treating apparatus comprises the reservoir of a storage of solvent, the heating chamber of one heated solvent, two solenoid valves and a force (forcing) pump being connected with described heating chamber, described pipeline comprises a front pipeline and a rear pipeline, reservoir and described heating chamber described in described front pipeline connection, heating chamber and described sense channel described in described rear pipeline connection, described two solenoid valves respectively group are located on described front pipeline and described rear pipeline, by described two solenoid valves, adjusting described reservoir and described heating chamber and described heating chamber and described sense channel is conducting state or hinders but state, described force (forcing) pump is as the function that pushes described solvent.
Preferably, the 3rd embodiment of the pick-up unit of the chemical substance quantitative and qualitative analysis of intelligent robotization of the present invention also comprises following technical characterictic, described perforation group comprises two needle tubing sheets that are oppositely arranged, described in each, the shape of needle tubing sheet and the structure of described testing container are corresponding, described in each, one end mask of needle tubing sheet has a plurality of needle tubings, when two needle tubing sheets clip the both sides of described testing container, a plurality of needle tubings of each needle tubing sheet can penetrate in described testing container.
Preferably, the 3rd embodiment of the pick-up unit of the chemical substance quantitative and qualitative analysis of intelligent robotization of the present invention also comprises following technical characterictic, the described joint portion of described inspection instrument is surface reinforced Raman active carrier (SERS-active substrate), the colloidal sol body that described surface reinforced Raman active carrier is metallic particles.
Preferably, the 3rd embodiment of the pick-up unit of the chemical substance quantitative and qualitative analysis of intelligent robotization of the present invention also comprises following technical characterictic, described smooth focus control group comprises a light supply apparatus and a spectrometer, described light supply apparatus can project laser light, ultraviolet light (UV), near infrared light (Near Infra red:NIR), far red light (Far Infra red:FIR) or visible ray, described light supply apparatus comprises a body, one light emitting source, one goes out shaven head, one group goes out bare headed focus regulating mechanism described in being located at, described light emitting source group is located at described intrinsic one end, described light emitting source projects the light of at least one wavelength, and produce at least one projecting light path and at least one backhaul light path, describedly go out the bare headed group of other end that is located at described body, it is described that to go out shaven head corresponding with described detection slide glass, described at least one projecting light path finally goes out shaven head to the described joint portion of described detection slide glass by described through one first collimation lens, a laser rays filtrator, a colo(u)r filter, a beam splitter in order, described projecting light path arrives one first focusing light path of described detection slide glass by beam splitter in described beam splitter generation one, by the second focusing light path of described beam splitter reflection, described the second focusing light path projects by one second focus lamp to one group of photosensory assembly that is located at described body with one, the described joint portion of detecting slide glass described at least one return light route in order through described in go out shaven head, described colo(u)r filter, a reflector plate, one second collimation lens and one group of long pass light filter that is located at described inner body wall, described long pass light filter and the electric connection of described spectrometer, described focus regulating mechanism, described photosensory assembly and described spectrometer and described electronic installation are electrically connected, described electronic installation is compared the difference of the path of described the first focusing light path and the path of the second focusing light path, by going out bare headed burnt section described in described focus regulating mechanism adjustment, goes out focal length bare headed and described inspection instrument described in adjusting.
More preferably, the 3rd embodiment of the pick-up unit of the chemical substance quantitative and qualitative analysis of intelligent robotization of the present invention also comprises following technical characterictic, described pick-up unit also comprises a light focus control device being electrically connected with described light emitting source, described light emitting source is provided with at least two luminescent grains, described smooth focus control device regulates and controls luminance and the emission wavelength of arbitrary luminescent grain, make described light emitting source project the light of at least one wavelength, and control wavelength, power, light intensity and the shinny state of luminescent grain.
More preferably, the 3rd embodiment of the pick-up unit of the chemical substance quantitative and qualitative analysis of intelligent robotization of the present invention also comprises following technical characterictic, described electronic installation comprises a data storage element, one receiving element and a processing unit, described data storage element and described receiving element and the mutual data transmission of described processing unit, described data storage element stores a plurality of example weight information, a plurality of sample Raman spectral information and a plurality of sample scattering strength values, described processing unit is by the weight information of thing to be identified thus, the relativeness of Raman spectral information and scattering strength numerical value, minimal square error method (Least Square Method) and the completely data analysis of restrictive condition minimal square error method (Full Constrained Least Square Method), compare a plurality of example weight information in described data storage element, a plurality of sample Raman spectral information and a plurality of sample scattering strength values are carried out baseline correction, subtracting each other of fluorescence spectrum, and data qualitative and quantitative analysis detects the contained chemical substance of thing.
More preferably, the 3rd embodiment of the detection method of the chemical substance quantitative and qualitative analysis of intelligent robotization of the present invention, described detection method Bao draws together Xia row Bu Zhou ︰ Yang product Dings Wei ︰ the testing container that is equipped with determinand is put in extraction equipment, described determinand is positioned on weight measurement unit, described weight measurement unit produces a weight information, and then operating switch part clips perforation group and partly penetrates described testing container; Rong Ji Chu Li ︰ heats the solvent in solvent treating apparatus and pressurizes and be transported to extraction equipment; Extraction is got described in ︰ solvent and is flow into and in described testing container, mix with determinand and produce an extract, extracts dropper the described extract of collection is splashed in described inspection instrument; Extract in Nong Suo ︰ heating and air blowing inspection instrument, makes solvent evaporates obtain a concentrate; Fen Xi ︰ light focus control group is irradiated behind the joint portion of described inspection instrument, read Raman spectrum signal, and be input to electronic installation analysis, described electronic installation analyses and comparison Raman spectrum signal and weight information, analyze chemical substance contained in thing to be detected.
More preferably, the 3rd embodiment of the detection method of the chemical substance quantitative and qualitative analysis of intelligent robotization of the present invention also comprises following technical characterictic; In analytical procedure, described electronic installation is by Raman spectrum signal, the weight information of thing to be detected and be stored in that a plurality of sample Raman spectrum signals wherein, a plurality of example weight information are compared, the data of the subtracting each other of baseline correction, fluorescence spectrum, data qualitative and quantitative analysis, application minimal square error method (Least Square Method) and complete restrictive condition minimal square error method (Full Constrained Least Square Method) analyze the contained chemical substance of thing to be detected.
More preferably, the 3rd embodiment of the detection method of the chemical substance quantitative and qualitative analysis of intelligent robotization of the present invention, described smooth focus control group is radiated the first light and the second light, the wavelength of described the first light and described the second light is very close, while detecting described thing to be detected by scanning, produce the first spectrogram and the second spectrogram, with this fluorescence spectrum, subtract each other the qualitative and quantitative result that obtains detecting dark sample with baseline correction, or described smooth focus control group is radiated a far red light, while scanning the described thing to be detected of detection with this, thereby produce Raman spectrogram containing the noise of fluorescence reach can detect dark sample qualitative and and quantitative result.
More preferably, the 3rd embodiment of the detection method of the chemical substance quantitative and qualitative analysis of intelligent robotization of the present invention, in solvent treatment step, described detection method pushes and has heated described solvent from described solvent treating apparatus to described extraction equipment with described force (forcing) pump, and described force (forcing) pump produces 0.1kg/cm 2～1000kg/cm 2the pressure of scope.Preferably, described solvent is organic solvent, hydrosolvent, mixed solvent or carbon dioxide.
Therefore, pick-up unit and the detection method of the chemical substance quantitative and qualitative analysis of intelligent robotization provided by the invention, reached the effect of quantitative and qualitative analysis thing to be detected, quick and easy operation, full-automatic and highly sensitive measuring ability are provided, allow user can detect fast the chemical substance that described thing to be detected comprises, and reached QC and detected qualitative and quantitative effect.
Accompanying drawing explanation
Fig. 1 is the schematic diagram of device of the first embodiment of pick-up unit of the present invention;
Cardon is made in the operating process of the first embodiment that Fig. 2-5 are pick-up unit of the present invention;
Fig. 6 is the solvent treating apparatus of the first embodiment of pick-up unit of the present invention and the enlarged diagram of extraction equipment;
Fig. 7 is the enlarged diagram of the enrichment facility of the first embodiment;
Fig. 8 is the enlarged diagram of detecting unit;
Fig. 9-10 are the second embodiment of pick-up unit of the present invention makes cardon; Figure 11 is the installation drawing of the 3rd embodiment of pick-up unit of the present invention;
Figure 12 is the 3rd enrichment facility of embodiment and the enlarged diagram of detecting unit of pick-up unit of the present invention;
Figure 13 is the schematic diagram of light supply apparatus;
Figure 14 is electronic installation figure;
Figure 15 is the profile of detection slide glass,
Figure 16 is the flow chart of steps of detection method first of the present invention and the 3rd embodiment;
Figure 17 is that the present invention detects the spectrogram of melamine with 785nm laser wavelength;
Figure 18 is for detecting the spectrogram of sensitivity of the present invention with the melamine of variable concentrations;
Figure 19 is for removing to proofread and correct in the intensity of the Raman spectral peaks of 520nm the spectrogram that reaches optimum focusing distance in 675.9nm Raman spectral peaks and silicon by comparing melamine;
Figure 20 is the flow chart of steps of the second embodiment of detection method of the present invention.
Description of reference numerals is as follows:
Testing container 1, solvent treating apparatus 2, reservoir 21, hot cell 22, solenoid valve 23, solenoid valve 24, force (forcing) pump 25, extraction equipment 3, positioning part 31, sense channel 32, perforation group 33, needle tubing sheet 331, needle tubing 3311, switch member 34, weight measurement unit 35, extraction dropper 36, titration end 361, endpiece 37, extraction board 38, pipeline 4, front pipeline 41, rear pipeline 42, the first pipeline 43, the first valve 431, the second pipeline 44, the second valve 441, enrichment facility 5, mobile platform 51, displacement motor 511, collection container 52, heating part 53, detecting unit 6, sampler 61, mobile motor 611, sampler 612, light focus control group 62, light supply apparatus 621, light emitting source 6211, luminescent grain 62111, go out shaven head 6213, focus regulating mechanism 6214, penetrate light path 6215, backhaul light path 6216, the first collimation lens 6217, laser rays filtrator 6218, colo(u)r filter 6219, beam splitter 6220, the first focusing light path 6221, the second focusing light path 6222, photosensory assembly 6224, reflector plate 6225, the second collimation lens 6226, long pass light filter 6227, spectrometer 622, light focus control device 623, detect slide glass 63, joint portion 631, concentrated limit collar 632, Raman spectrum optically focused focus sheet 633, electronic installation 7, data storage element 71, receiving element 72, processing unit 73, test tubes 8, joint portion 81, inspection instrument 9 and joint portion 91.
Embodiment
In order to make auditor can further understand structure of the present invention, feature and other objects, now in conjunction with appended preferred embodiment, being accompanied by accompanying drawing is described in detail as follows, use the illustrated embodiment of this accompanying drawing only for technical scheme of the present invention is described, and non-limiting the present invention.
Shown in Fig. 1 to Fig. 5, be the first embodiment of the pick-up unit of the chemical substance quantitative and qualitative analysis of a kind of intelligent robotization of the present invention, Bao Kuo ︰ mono-testing container 1, testing container 1 is for storing thing to be detected; One solvent treating apparatus 2, for storage, heating and pressurized solvent (the present embodiment is usingd the packings such as stainless steel, glass, capsule-type as testing container 1, and thing to be detected can be through the food of processing such as smashing, grind and medicine etc.).
One extraction equipment 3, comprise an extraction board 38, one perforation group 33, one switch member 34, one weight measurement unit 35 and an extraction dropper 36, extraction board 38 is provided with a positioning part 31, in extraction board 38, be provided with a sense channel 32 being connected with positioning part 31, perforation is organized 33 activity groups and is located in sense channel 32, perforation group 33 clips and pierces through testing container 1, switch member 34 is hubbed on extraction board 38, and organize 33 interlock settings with perforation, weight measurement unit 35 is corresponding with positioning part 31, and group is located at sense channel 32, 36 groups of ends that are located at extraction board 38 of extraction dropper, and be connected with sense channel 32, extraction dropper 36 is provided with a titration end 361, solvent is mixed to form extract via extraction board 38 with thing to be detected, weight measurement unit 35 output weight information, one pipeline 4, pipeline 4 is communicated with the sense channel 32 of solvent treating apparatus 2 and extraction equipment 3.
One enrichment facility 5, comprise a mobile platform 51 and a collection container 52, mobile platform 51 is provided with a heating part 53, collection container 52 is placed on heating part 53, extract is by heating and extract the volatilization of the mode accelerated solvent of dropper 36 air blowings, thereby the concentration that promotes extract, makes extract become concentrate.
One detecting unit 6, comprise that the smooth focus control group 62 of a sampler 61, one and detects slide glass 63, detecting 63 groups of slide glasses is located on mobile platform 51, the end face that detects slide glass 63 is provided with a joint portion 631, the molecule of joint portion 631 in concentrate is combined, and after light focus control group 62 throw lights, reads a Raman spectrum signal.
One electronic installation 7, electronic installation 7 of the present invention can be computer equipment or other electronic product, electronic installation 7 electrically connect solvent treating apparatus 2, extraction equipment 3, enrichment facility 5, detecting unit 6, electronic installation 7 receives contained chemical substance in Raman spectrum signal analyzing and testing thing, and electronic installation 7 receives weight information simultaneously.
The second embodiment of the pick-up unit of the chemical substance quantitative and qualitative analysis of intelligent robotization of the present invention, refers to Fig. 9 and Figure 10, this pick-up unit Bao Kuo ︰ mono-testing container 1, and testing container 1 is for storing thing to be detected, one solvent treating apparatus 2, for storing and heated solvent, one extraction equipment 3, extraction equipment 3 is provided with a positioning part 31, extraction equipment 3 is provided with a sense channel 32 being connected with positioning part 31, extraction equipment 3 comprises a perforation group 33, one switch member 34, one weight measurement unit 35 and an endpiece 37, perforation is organized 33 activity groups and is located in sense channel 32, perforation group 33 clips and pierces through testing container 1, switch member 34 is hubbed on extraction equipment 3, and organize 33 interlock settings with perforation, weight measurement unit 35 is corresponding with positioning part 31, and group is located at sense channel 32, endpiece 37 is connected with sense channel 32, the solvent having heated is imported in sense channel 32 by pipeline 4, and thereby the thing to be detected dissolving in testing container 1 through perforation group 33 produces extract, weight measurement unit 35 output weight information, one pipeline 4, pipeline 4 is communicated with the sense channel 32 of solvent treating apparatus 2 and extraction equipment 3, one test tubes 8,8 groups of test tubes are located at endpiece 37 and are connected with sense channel 32, and in test tubes 8, around a joint portion 81 is set, this extract is passed in test tubes 8 and joint portion 81 combinations, one detecting unit 6, comprises a smooth focus control group 62, and light focus control group 62 throw lights read a Raman spectrum signal behind joint portion 81, one electronic installation 7, with solvent treating apparatus 2, extraction equipment 3, detecting unit 6 electrically connects, electronic installation 7 receives Raman spectrum signal, and analyzes Raman spectrum signal, obtain the contained chemical substance information in thing that detects, electronic installation 7 receives this weight information.
Thus, by solvent treating apparatus 2 and extraction equipment 3, obtain concentrate, and by after the molecule of concentrate and 81 combinations of the joint portion of test tubes 8, via light focus control group 62, read weight information that Raman spectrum signal and weight measurement unit 35 provide to electronic installation 7, after the weight information and Raman spectrum signal of electronic installation 7 by this thing to be detected of analysing and comparing, reconfigure the chemical substance of thing to be detected, reach the effect of quantitative and qualitative analysis thing to be detected, provide fast and easily and operate, full-automatic and highly sensitive measuring ability, allow user can detect fast the chemical substance that thing to be detected comprises, and (discrepancy of the second embodiment of the present invention and the first embodiment is to reach the effect of QC and detection, the present invention only need be by being installed in the test tubes 8 of the end of extraction equipment 3, make molecule and test tubes 8 combinations in extract, can be in addition qualitative, the molecule of quantified extract liquid and analyze the chemical composition of extract, and do not need enrichment facility 5, because other device is identical with the first embodiment with structure, no longer repeat specification).
The 3rd embodiment of the pick-up unit of the chemical substance quantitative and qualitative analysis of intelligent robotization of the present invention, refers to Figure 11 and Figure 12, and this pick-up unit comprises, a testing container 1, and testing container 1 is for storing thing to be detected, one solvent treating apparatus 2, for storage, heating and pressurized solvent, one extraction equipment 3, comprise an extraction board 38, one perforation group 33, one switch member 34, one weight measurement unit 35 and an extraction dropper 36, extraction board 38 is provided with a positioning part 31, in extraction board 38, be provided with a sense channel 32 being connected with positioning part 31, perforation is organized 33 activity groups and is located in sense channel 32, perforation group 33 clips and pierces through testing container 1, switch member 34 is hubbed on extraction equipment 3, and organize 33 interlock settings with perforation, weight measurement unit 35 is corresponding with positioning part 31, and group is located at sense channel 32, 36 groups of ends that are located at extraction board 38 of extraction dropper, and be connected with sense channel 32, extraction dropper 36 is provided with a titration end 361, solvent is mixed to form extract via extraction equipment 3 and thing to be detected, weight measurement unit 35 output one weight informations, one pipeline 4, pipeline 4 is communicated with the sense channel 32 of solvent treating apparatus 2 and extraction equipment 3, one enrichment facility 5, comprise a mobile platform 51 and an inspection instrument 9, mobile platform 51 is provided with a heating part 53, inspection instrument 9 is seated in heating part 53, in inspection instrument 9, there is a joint portion 91, extract is in inspection instrument 9, through heating and blow concentrated become concentrate, the molecule in this concentrate and joint portion 91 combinations, one detecting unit 6, comprise a smooth focus control group 62, light focus control group 62 comprises a light supply apparatus 621 (light supply apparatus 621 of the present embodiment is laser head), one end of light supply apparatus 621 is provided with one and goes out shaven head 6213, go out shaven head 6213 and wear mobile platform 51 and corresponding with the joint portion 91 of inspection instrument 9, light supply apparatus 621 throw lights read a Raman spectrum signal through going out shaven head 6213 behind joint portion 91, one electronic installation 7, with solvent treating apparatus 2, extraction equipment 3, enrichment facility 5, detecting unit 6 electrically connects, electronic installation 7 receives contained chemical substance in Raman spectrum signal analyzing and testing thing, and electronic installation 7 receives this weight information simultaneously.
Thus, by solvent treating apparatus 2 and extraction equipment 3, obtain extract, and by the molecule of this extract and joint portion 91 combinations of inspection instrument 9, and by heating and air blowing process by extract simmer down to concentrate, by light focus control group 62, read weight information that Raman spectrum signal and weight measurement unit 35 provide to electronic installation 7 again, after the weight information and Raman spectrum signal of electronic installation 7 these things to be detected of analyses and comparison, reconfigure the chemical substance of this thing to be detected, to reach the effect of quantitative and qualitative analysis thing to be detected, provide fast and easily and operate, full-automatic and highly sensitive measuring ability, allow user can detect fast the chemical substance that thing to be detected comprises, and reach the effect of QC and detection, above-mentioned is the embodiment explanation of low-concentration liquid sample.
The third embodiment of the present invention, when detecting high concentration liquid or powdery solid sample, in the 3rd embodiment, the high concentration liquid or the solid-state determinand of powdery that are equipped with two milliliters are put in inspection instrument 9, light supply apparatus 621 automatic focuses are positioned at the joint portion 91 of inspection instrument 9 and read Raman spectrum (Raman Spectrum), and input draws diffuse spectrum (Raman Spectrum) to electronic installation 7.
In addition, the first embodiment of the pick-up unit of the chemical substance quantitative and qualitative analysis of intelligent robotization of the present invention, the second embodiment and the 3rd embodiment comprise following technical characterictic.
(1) refer to shown in Fig. 2, solvent treating apparatus 2 comprises the reservoir 21 of a storage of solvent, the heating chamber 22 of one heated solvent, two solenoid valves 23, the force (forcing) pump 25 of the 24 and one force (forcing) pump 25(being connected with heating chamber 22 of the present invention first and the 3rd embodiment is pump, the force (forcing) pump 25 of the second embodiment is air-pot), pipeline 4 comprises a front pipeline 41 and a rear pipeline 42, front pipeline 41 is communicated with reservoir 21 and heating chamber 22, rear pipeline 42 is communicated with heating chamber 22 and sense channel 32, two solenoid valves 23 respectively group are located on front pipeline 41 and rear pipeline 42, by two solenoid valves 23, adjusting reservoir 21 is conducting state with sense channel 32 or hinders but state with heating chamber 22 and heating chamber 22, force (forcing) pump 25 start the rear product power of boosting push solvent by pipeline 4 in sense channel 32, after finally mixing with the detection material in testing container 1, push extract and arrive outer function through extraction dropper 36, in addition when the solenoid valve 23 that is arranged on front pipeline 41 is during for closed condition, start force (forcing) pump 25 can promote gas in heating chamber 22 through after pipeline 42, sense channel 32 is outside extraction dropper 36, thereby reach the effect of air blowing.Pipeline 4 in the second embodiment of the present invention comprises one first pipeline 43 and one second pipeline 44, the first pipeline 43 is communicated with force (forcing) pump 25 and sense channel 32, the second pipeline 44 is communicated with reservoir 21 and sense channel 32, and on the first pipeline 43, be provided with on one first valve 431, the second pipelines 44 and be provided with one second valve 441.
(2) refer to shown in Fig. 2 and Fig. 7, further illustrate the detailed structure of perforation group 33, perforation group 33 comprises two needle tubing sheets 331 that are oppositely arranged, when testing container 1 is put into sense channel 32 from positioning part 31, two needle tubing sheets 331 lay respectively at front end face and the rear end face of testing container 1, the shape of each needle tubing sheet 331 is corresponding with the structure of testing container 1, one end mask of each needle tubing sheet 331 has a plurality of needle tubings 3311, when two needle tubing sheets 331 clip the both sides of testing container 1, a plurality of needle tubings 3311 of each needle tubing sheet 331 can penetrate in testing container 1, inside and the sense channel 32 of testing container 1 are interconnected.
(3) refer to Fig. 1, shown in Fig. 9 and Figure 11, light focus control group 62 comprises that a light supply apparatus 621 and a spectrometer 622(the present embodiment are Raman spectrometer), light supply apparatus 621 can project laser light, ultraviolet light (UV), near infrared light (Near Infra red:NIR), far red light (Far Infra red:FIR) or visible ray, the present embodiment is laser light, light supply apparatus 621 comprises a light emitting source 6211, one goes out shaven head 6213, one group of focus regulating mechanism 6214 that is located at out shaven head 6213, 6211 groups of one end that are located in light supply apparatus 621 of light emitting source, the light of at least one wavelength of light emitting source 6211 projection (for example 785nm or 638nm, or 532nm), and produce at least one projecting light path 6215 and at least one backhaul light path 6216, go out bare headed 6213 groups of other ends that are located at light supply apparatus 621, go out shaven head 6213 corresponding with detection slide glass 63, at least one projecting light path 6215 is in order through one first collimation lens 6217, one laser rays filtrator 6218, one colo(u)r filter 6219(is 45 degree and tilts), one beam splitter 6220(T95/R5 beam splitter 6220, being negative 45 degree tilts) finally by going out bare headed 6213(, go out shaven head 6213 and be provided with focusing lens) to the joint portion 631 of detecting slide glass 63, projecting light path 6215 is at beam splitter 6220(T95/R5 beam splitter 6220) produce one by beam splitter 6220 to the one first focusing light path 6221 that detects slide glass 63, with a second focusing light path 6222 being reflected by beam splitter 6220, the second focusing light path 6222 projection is located at the photosensory assembly 6224 (photosensory assembly 6224 is photoelectric diode) of light supply apparatus 621 by 6223 to one groups of one second focus lamps, and (light of this at least one wavelength is after beam splitter 6220, 95% light ray energy enters into the first focusing light path 6221, the light ray energy of this at least one wavelength of 5% enters into the second focusing light path 6222), angle between the first focusing light path 6221 and the second focusing light path 6222 is right angle, and see through the difference of electronic installation 7 paths of comparison the first focusing light path 6221 and the path of the second focusing light path 6222 by focus regulating mechanism 6214(voice coil motor) adjusting focal length, focal range is 5 millimeters to 8 millimeters, focus regulating mechanism 6214, photosensory assembly 6224 and spectrometer 622 are electrically connected with electronic installation 7.
At least one backhaul light path 6216 passes through shaven head 6213 in order from detecting the joint portion 631 of slide glass 63, colo(u)r filter 6219, one reflector plate 6225, one second collimation lens 6226 and one group of long pass light filter 6227 that is located at the inwall of light supply apparatus 621, (long pass light filter 6227 is electrically connected by fibre system with spectrometer 622 long pass light filter 6227 with spectrometer 622 electric connections, this is to know technology, so be no longer illustrated its details, make flowing mode), light focus control group 62 can read Raman spectrum (Raman Spectrum) thus, and be input to electronic installation 7 and carry out qualitative and quantitative analysis.
(4) please refer to shown in Fig. 1 and Figure 17, in order to control the wavelength of light emitting source 6211 projections, power, light intensity and shinny state, for example select the far infrared light emitting source 6211 of the radiation of fluorescence excitation to reduce the generation of background fluorescence noise, also comprise a light focus control device 623 being electrically connected with light emitting source 6211, light emitting source 6211 is provided with at least two luminescent grains 62111, luminance and the emission wavelength of the arbitrary luminescent grain 62111 of light focus control device 623 regulation and control, the present embodiment is by two luminescent grains 62111, project respectively light (for example 784nm and the 785nm of two kinds of different wave lengths, or 637nm and 638nm, or 531nm and 532nm), and compare the background fluorescence noise that two light reduce generation.
(5) refer to shown in Figure 16, electronic installation 7 comprises a data storage element 71, one receiving element 72 and a processing unit 73, data storage element 71 and receiving element 72 and the mutual data transmission of processing unit 73, data storage element 71 stores a plurality of example weight information, a plurality of sample Raman spectral information and a plurality of sample scattering strength values, processing unit 73 is by the weight information of thing to be identified thus, the relativeness of Raman spectral information and scattering strength numerical value, minimal square error method (Least Square Method) and the completely data analysis of restrictive condition minimal square error method (Full Constrained Least Square Method), the plurality of example weight information in comparison data storage element 71, these multiple a plurality of sample Raman spectral information and the plurality of sample scattering strength values are carried out baseline correction, subtracting each other of fluorescence spectrum, and data qualitative and quantitative analysis detects the contained chemical substance of thing.
(6) refer to shown in Fig. 7, mobile platform 51 comprises a plurality of displacement motors 511, and a plurality of displacement motors 511 provide the multidirectional displacement of mobile platform 51 and rotation.
(7) refer to shown in Fig. 1, this sampler 61 comprises a plurality of mobile motors 611 and a sampler 612, a plurality of mobile motors 611 provide the multidirectional displacement of sampler 612 and rotation, sampler 612 is quantitative pin (Syringe), quantitative liquid suction pipe (Pipette) or electronic automatic ration aspirator (Motorized Auto-Pipette), by electronic installation 7, control the displacement motor 511 of complex digital on mobile platform 51 and be positioned at the mobile motor 611 in sampler 612, reaching full-automatic effect.
In addition, the first embodiment of the present invention, refer to shown in Figure 15, detecting slide glass 63(, to detect slide glass 63 be detection chip) joint portion 631, the joint portion 81 of test tubes 8 of the second embodiment and the joint portion of the inspection instrument 9 of the 3rd embodiment 91 be chemical, physics or biologic facies affinity concentrated carrier or surface reinforced Raman active carrier (SERS-active substrate), surface reinforced Raman active carrier is the colloidal sol body of metallic particles, as silver, gold, copper, nickel ... Deng.Metal surface has the rough surface of be situated between sight or microcosmic, by the chemical molecular in concentrate, the functional group of metal surface can be adsorbed by active carrier, utilize like this Surface Enhanced Raman Scattering Spectrum (SERS) to carry out the Spectral Identification on micro-Molecular Identification and Nai meter surface, even if by a small amount of molecular weight, also can reach highly sensitive evaluation like this.Wherein 631 surfaces, joint portion of the first embodiment are provided with a Raman spectrum optically focused focus sheet 633, Raman spectrum optically focused focus sheet 633 is silicon chip or other Raman unit spectrum standard specimen, supply the application of optically focused focusing, and 631 periphery is provided with a concentrated limit collar 632 (Retaining Ring) in joint portion, the material of concentrated limit collar 632 is paraffin ring, Te Folong (Teflon) or the relative chemistry of other cooperation concentrate, physics, the chemical material of biological repellency mutually or affinity, be used for limiting concentrate and be added drop-wise to the scope of detection slide glass 63 and homogeneity and the reliability that keeps concentrate to distribute.The light scanning Raman spectrum optically focused focus sheet 633 that light emitting source 6211 projection wavelength are 520nm, reaches maximum intensity and automatically sets light source to detecting the focus point of slide glass 63.
According to the first embodiment of the pick-up unit of the chemical substance quantitative and qualitative analysis of aforesaid intelligent robotization of the present invention and further technical characterictic, go on to say the detection method of the chemical substance quantitative and qualitative analysis of intelligent robotization of the present invention, refer to Figure 12 and coordinate shown in Fig. 1 to Fig. 8 simultaneously, (1) Yang product are Dinged Wei ︰ the testing container 1 that is equipped with determinand are put into extraction equipment 3, determinand is positioned on weight measurement unit 35, weight measurement unit 35 produces weight information, then operating switch part 34 clips perforation group 33 and partly penetrates testing container 1, close positioning part 31 simultaneously, (2) Rong Ji Chu Li ︰ heats the solvent in solvent treating apparatus 2 (solvent is organic solvent, hydrosolvent, mixed solvent or carbon dioxide) and pressurizes and be transported to extraction equipment 3, its particular procedures is positioned at front pipeline 41 solenoid valve 23 for starting allows solvent flow to heating chamber 22 from reservoir 21 and is heated to design temperature, and then shut electromagnetic valve 23.(3) extraction is got ︰ solvent and is flowed into and in testing container 1, to mix with determinand and to produce extract, and extraction dropper 36 splashes into this extract of collecting in collection container 52, its particular procedures is to adjust mobile platform 51 to make collection container 52 openings aim at the titration end 361 of extraction dropper 36, start the solenoid valve 24 that is positioned at rear pipeline 42, and starting force (forcing) pump 25 is sent to the solvent having heated in sense channel 32, and from mixing with determinand in needle tubing sheet 331 flow into testing container 1 and producing extract, by extraction dropper 36, the extract of collection is splashed into (force (forcing) pump 25 generation 0.1kg/cm in collection container 52 again 2～1000kg/cm 2the pressure of scope).(4) Nong Suo ︰ heating and the extract volatilization of accelerating in collection container 52 of blowing obtain a concentrate, (5) Fen Xi ︰ samplers 61 are drawn this concentrate, and this concentrate is added drop-wise to and detects slide glass 63 and joint portion 631 in conjunction with after blow dried again, after irradiating by light focus control group 62, read Raman spectrum signal, and being input to electronic installation 7 analyzes, electronic installation 7 analyses and comparison Raman spectrum signal and weight informations, analyze chemical substance contained in thing to be detected, its particular procedures is that displacement motor 511 is displaced to mobile platform 51 below of sampler 612, sampler 612 makes the end of sampler 612 insert in collection container 52 by mobile motor 611 and mobile motor 611 is drawn quantitatively (for example 0.5 microlitre) concentrate, rear displacement motor 511 makes to detect slide glass 63 and aims at sampler 612, the concentrate of absorption is added drop-wise to the joint portion 631 of detecting slide glass 63, carry out sample after fast dry-cure joint portion 631, displacement motor 511 is displaced to light focus control group 62 times by mobile platform 51, by throw light (laser laser) and spectrometer 622(Raman spectrometer) read Raman spectrum (Raman Spectrum), and being input to electronic installation 7 reads Raman spectrum (Raman spectrum) and compares.
Wherein, the first embodiment of the detection method of the chemical substance quantitative and qualitative analysis of intelligent robotization of the present invention comprises following further technical characterictic.
(1) in analytical procedure, electronic installation 7 is by the Raman spectrum signal of thing to be detected, weight information be stored in a plurality of sample Raman spectrum signals in electronic installation 7, plural number example weight information is compared, baseline correction, subtracting each other of fluorescence spectrum, data qualitative and quantitative analysis, application minimal square error method (Least Square Method) and the completely data of restrictive condition minimal square error method (Full Constrained Least Square Method) are analyzed the contained chemical substance of thing to be detected, with this, provide full-automatic and operation easily, reach fast detecting, qualitative, quantitatively treat the result of the detection thing in side container 1.
(2) in order to reduce noise, light focus control group 62 radiation the first light and the second light, the wavelength of this first light and this second light is very close, while scanning detection thing to be detected with this, produce the first spectrogram and the second spectrogram, with this fluorescence spectrum, subtract each other the quantitative and qualitative analysis result that obtains detecting dark sample with baseline correction, or this light focus control group 62 radiation one far red lights, while scanning detection thing to be detected with this, thereby generation does not contain the result that the Raman spectrogram of the noise of fluorescence reaches the quantitative and qualitative analysis that can detect dark sample, (opticpath of the first light or the second light is all identical with Figure 13 to be for example applied in the result of red wine quantitative and qualitative analysis, so draw and represent no longer in addition, and no longer repeat specification).
Refer to shown in Figure 17, Figure 17 is that the present invention is that 785nm detects melamine (Melamine) (chemical formula: C by laser wavelength 3h 6n 6), chemical structural formula is as Xia ︰
Figure BDA0000393594720000241
Ordinate of orthogonal axes in Figure 17 is intensity (Intensity (counts/s)), and transverse axis coordinate is wave number (Wavenumber (cm -1)), melamine is at 378.7cm -1, 387.6cm -1, 581.5cm -1, 675.9cm -1, 774.7cm -1, 986.2cm -1, 1445.3cm -1, 1560.2cm -1intensity stronger, at 675.9cm -1crest the highest.
Refer to shown in Figure 18, Figure 18 is that the present invention measures melamine (Melamine) in the sensitivity detecting on slide glass 63 (SERS) substrate by laser wavelength 785nm, and gained Raman shift spectrum is at 300cm -1to 1800cm -1scope, in figure, A is respectively the melamine (Melamine) of variable concentrations to F, the concentration of A is 10 -2molL -1, B concentration be 10 -3molL -1, C concentration be 10 -4molL -1, D concentration be 10 -5molL -1, E concentration be 10 -6molL -1, F concentration be 10 -7molL -1, G is SERS substrate gold material (gold subtrate), as seen from Figure 20, E of the present invention still can significantly measure 676cm -1crest, so sensitivity of the present invention can reach the concentration of melamine (Melamine), be 10 -6molL -1.
Refer to shown in Figure 20, Figure 20 is that the present invention is by 10 -4m melamine is detecting slide glass 63(SERS substrate) upper resulting at 675.9nm (melamine) with at the Raman spectrum of 520nm (Si) by adjusting focusing distance..When focusing distance reaches best raman spectrum strength when C is transferred to B to A, A is best focusing distance.
The present invention is according to the pick-up unit of the chemical substance quantitative and qualitative analysis of above-mentioned intelligent robotization, further illustrate second embodiment of detection method of the chemical substance quantitative and qualitative analysis of intelligent robotization of the present invention, refer to shown in Figure 20, coordinate again shown in Fig. 9 and Figure 10 simultaneously, this detection method Bao draws together Xia row Bu Zhou ︰ () Yang product Dings Wei ︰ the testing container 1 that determinand is housed is put into extraction equipment 3, and then operating switch part 34 makes perforation group 33 clip testing container 1 and part penetrates testing container 1; (2) Rong Ji Chu Li ︰ is by the solvent heating in solvent treating apparatus 2 and be pressed and delivered to extraction equipment 3; (3) extraction is got ︰ solvent and is flow into the interior generation extract that mixes with determinand of testing container 1; (4) Fen Xi ︰ extracts are delivered to test tubes 8 from endpiece 37, molecule in this extract and joint portion 81 combinations, after heating and blow dried, by light focus control group 62, read a Raman spectrum signal, and be input to electronic installation 7 and analyze, electronic installation 7 comparison Raman spectrum signals and weight information are analyzed contained chemical substance in this thing to be detected.(difference of the steps flow chart of the steps flow chart of the second embodiment of the present invention and the first embodiment is, the second embodiment does not need concentration step, but directly by extraction equipment 3, derive this extract in test tubes 8, the detailed process of other flow process is identical with the first embodiment, so no longer repeat specification).
The second embodiment of the detection method of the chemical substance quantitative and qualitative analysis of intelligent robotization of the present invention also comprises that following Ji art Te Zheng ︰ () is in analytical procedure, electronic installation 7 is by the Raman spectrum signal of thing to be detected, weight information be stored in a plurality of sample Raman spectrum signals in electronic installation 7, a plurality of example weight information is compared, baseline correction, subtracting each other of fluorescence spectrum, data qualitative and quantitative analysis, application minimal square error method (Least Square Method) and the completely data of restrictive condition minimal square error method (Full Constrained Least Square Method) are analyzed the contained chemical substance of thing to be detected.(2) light focus control group 62 radiation the first light and the second light, the wavelength of this first light and the second light is close, while scanning this thing to be detected of detection with this, produce the first spectrogram and the second spectrogram, with this fluorescence spectrum, subtract each other the quantitative and qualitative analysis result that obtains detecting dark sample with baseline correction, or light focus control group 62 radiation one far red lights, while scanning this thing to be detected of detection with this, thereby not containing the Raman spectrogram of the noise of fluorescence, generation do not reach the quantitative and qualitative analysis result that can detect dark sample.(3), in Sample location step, the weight data that this determinand is measured in weight measurement unit 35 is in electronic installation 7.(4), in solvent treatment step, open the second valve 441 and make the solvent in reservoir 21 be sent to heating chamber 22 heating.(5) this solvent is organic solvent, water, mixed solvent or carbon dioxide.(6), in solvent treatment step, the air pressure of the gas that force (forcing) pump 25 is sent is 0.1kg/cm 2～1000kg/cm 2.(7) in extraction step, open the first valve 431 gas in force (forcing) pump 25 flow in sense channel 32, and push solvent in testing container 1, finally in test tubes 8 with joint portion 81 combinations.
In above-mentioned further art feature (one) to (six) of the second embodiment of the detection method of the chemical substance quantitative and qualitative analysis of intelligent robotization of the present invention is identical with the details process step in the first embodiment, so no longer repeat specification.
The present invention is according to the pick-up unit of the chemical substance quantitative and qualitative analysis of above-mentioned intelligent robotization of the present invention, further illustrate the 3rd embodiment of detection method of the chemical substance quantitative and qualitative analysis of intelligent robotization of the present invention, refer to shown in Fig. 6 and while figure 11 and Figure 12, the step Bao Kuo ︰ Yang product of this detection method are Dinged Wei ︰ the testing container 1 that is equipped with determinand are put into extraction equipment 3, this determinand is positioned on weight measurement unit 35, weight measurement unit 35 produces weight information, then operating switch part 34 clips perforation group 33 and partly penetrates testing container 1, Rong Ji Chu Li ︰ is by the solvent heating in solvent treating apparatus 2 and pressurization and be transported to extraction equipment 3(solvent and process and by force (forcing) pump 25, push that heated solvent is from solvent treating apparatus 2 to extraction equipment 3, and force (forcing) pump 25 produces 0.1kg/cm 2～1000kg/cm 2the pressure of scope), extraction is got this solvent of ︰ and is flow into and in testing container 1, mix with determinand and produce an extract, and extraction dropper 36 is added drop-wise to inspection instrument 9 interior (being organic solvent, hydrosolvent or mixed solvent in the present embodiment) by this extract of collecting, this extract in Nong Suo ︰ heating and air blowing inspection instrument 9, makes solvent evaporates obtain a concentrate, behind the joint portion 91 of Fen Xi ︰ light focus control group 62 irradiating and detecting containers 9, read Raman spectrum signal, and be input to electronic installation 7 and analyze, electronic installation 7 this Raman spectrum signal of analyses and comparison and these weight informations, analyze chemical substance contained in thing to be detected.
After the 3rd embodiment of the detection method of the chemical substance quantitative and qualitative analysis of intelligent robotization of the present invention also comprises that this detection method of following Ji art Te Zheng ︰ () is joint portion 91 combinations in concentrate and inspection instrument 9, directly by 62 irradiations of light focus control group, obtain Raman spectrum, and this Raman spectrum is transferred in electronic installation 7 and is compared.(2) in addition, in analytical procedure, electronic installation 7 is compared the Raman spectrum signal of thing to be detected and weight information and a plurality of sample Raman spectrum signals and a plurality of example weight information that are stored in electronic installation 7, baseline correction, subtracting each other of fluorescence spectrum, data qualitative and quantitative analysis, the data of application minimal square error method (Least Square Method) and complete restrictive condition minimal square error method (Full Constrained Least Square Method) are analyzed the contained chemical substance of thing to be detected, and (effect reached of this detection method is crossed identical with the first and second embodiment, so no longer repeat specification).
Therefore, pick-up unit and the detection method of the chemical substance quantitative and qualitative analysis of intelligent robotization provided by the invention, reach the effect of quantitative and qualitative analysis thing to be detected, quick and easy operation, full-automatic and highly sensitive measuring ability are provided, allow user can detect fast the chemical substance that described thing to be detected comprises, and reach QC and detect qualitative and quantitative effect.
Need statement, foregoing invention content and embodiment are intended to prove the practical application of technical scheme provided by the present invention, should not be construed as limiting the scope of the present invention.Those skilled in the art are in spirit of the present invention and principle, when doing various modifications, be equal to and replace or improve.Protection scope of the present invention is as the criterion with appended claims.

Claims (41)

1. a pick-up unit for the chemical substance quantitative and qualitative analysis of intelligent robotization, is characterized in that, described pick-up unit bag is drawn together ︰
One testing container, for storing thing to be detected;
One solvent treating apparatus, for storage, heating and pressurized solvent;
One extraction equipment, described extraction equipment comprises an extraction board, one perforation group, one switch member, one weight measurement unit and an extraction dropper, described extraction board is provided with a positioning part, and in described extraction board, be provided with a sense channel being connected with described positioning part, described perforation group activity group is located in described sense channel, described switch member and the setting of described perforation group interlock, described weight measurement unit is corresponding with described positioning part, and group is located at described sense channel, described extraction dropper group is located at the end of described extraction board, and be connected with described sense channel, described extraction dropper is provided with a titration end, described solvent is mixed to form extract by described extraction board and described thing to be detected, a weight information is exported in described weight measurement unit,
One pipeline, the sense channel of solvent treating apparatus and described extraction equipment described in described pipeline connection;
One enrichment facility, described enrichment facility comprises a mobile platform and a collection container, described mobile platform is provided with a heating part, and described collection container is seated in described heating part, and by heating and extract mode that dropper blows by described extract simmer down to one concentrate;
One detecting unit, described detecting unit comprises that an adjustment type sampler, a smooth focus control group and detect slide glass, described detection slide glass group is located on mobile platform, the end face of described detection slide glass is provided with a joint portion, the molecule of described joint portion in described concentrate is combined, and after described smooth focus control group throw light, reads a Raman spectrum signal;
One electronic installation, described electronic installation and described solvent treating apparatus, described extraction equipment, described enrichment facility, described detecting unit electrically connect, described electronic installation receives Raman spectrum signal and carrys out chemical substance contained in analyzing and testing thing, and described electronic installation receives described weight information simultaneously;
Thus, after the molecule of concentrate is combined with detection slide glass, by described smooth focus control group, read weight information that Raman spectrum signal and weight measurement unit provide to described electronic installation, described electronic installation carries out, after the weight information of thing to be detected and the compare of analysis of Raman spectrum signal, reconfiguring the chemical substance of thing to be detected.
2. pick-up unit according to claim 1, it is characterized in that, described solvent treating apparatus comprises the reservoir of a storage of solvent, the heating chamber of one heated solvent, two solenoid valves and a force (forcing) pump being connected with heating chamber, described pipeline comprises a front pipeline and a rear pipeline, reservoir and described heating chamber described in described front pipeline connection, heating chamber and described sense channel described in described rear pipeline connection, described two solenoid valves respectively group are located on described front pipeline and described rear pipeline, by described two solenoid valves, adjust described reservoir and described heating chamber, and described heating chamber and described sense channel are conducting state or hinder but state, described force (forcing) pump is as pushing described solvent.
3. pick-up unit according to claim 1, it is characterized in that, described perforation group comprises two needle tubing sheets that are oppositely arranged, described in each, the shape of needle tubing sheet and the structure of described testing container are corresponding, described in each, one end mask of needle tubing sheet has a plurality of needle tubings, when described two needle tubing sheets clip the both sides of described testing container, described a plurality of needle tubings of described each needle tubing sheet can penetrate in described testing container.
4. pick-up unit according to claim 1, it is characterized in that, the described joint portion of described detection slide glass is surface reinforced Raman active carrier, the colloidal sol body that described surface reinforced Raman active carrier is metallic particles, the surface of described joint portion is provided with a Raman spectrum optically focused focus sheet, and the periphery in described joint portion is provided with a concentrate limit collar, the material of described concentrate limit collar is paraffin ring or Te Folong.
5. pick-up unit according to claim 4, it is characterized in that, described smooth focus control group comprises a light supply apparatus and a spectrometer, described light supply apparatus projection laser light, ultraviolet light, near infrared light, far red light or visible ray, described light supply apparatus comprises a body, one light emitting source, one goes out shaven head, one group goes out bare headed focus regulating mechanism described in being located at, described light emitting source group is located at described intrinsic one end, described light emitting source projects the light of at least one wavelength, and produce at least one projecting light path and at least one backhaul light path, describedly go out the bare headed group of other end that is located at described body, it is described that to go out shaven head corresponding with described detection slide glass,
Described at least one projecting light path finally goes out shaven head to the described joint portion of described detection slide glass by described by one first collimation lens, a laser rays filtrator, a colo(u)r filter, a beam splitter in order, described projecting light path arrives one first focusing light path of described detection slide glass by described beam splitter in described beam splitter generation one, by the second focusing light path of described beam splitter reflection, described the second focusing light path projects by one second focus lamp to one group of photosensory assembly that is located at described body with one;
Described at least one backhaul light path goes out shaven head, described colo(u)r filter, a reflector plate, one second collimation lens and one group of long pass light filter that is located at described inner body wall described in passing through in order by the described joint portion of described detection slide glass, and described long pass light filter and described spectrometer are electrically connected;
Described focus regulating mechanism, described photosensory assembly and described spectrometer and described electronic installation are electrically connected;
Described electronic installation is compared the difference of the path of described the first focusing light path and the path of described the second focusing light path, automatically described in adjusting by described focus regulating mechanism, go out bare headed burnt section, described in adjusting, go out focal length bare headed and described detection slide glass.
6. pick-up unit according to claim 5, it is characterized in that, described pick-up unit also comprises a light focus control device being electrically connected with described light emitting source, described light emitting source is provided with at least two luminescent grains, luminance and the emission wavelength of the arbitrary described luminescent grain of described smooth focus control device regulation and control, make described light emitting source project the light of at least one wavelength, and control wavelength, power, light intensity and the shinny state of described luminescent grain.
7. pick-up unit according to claim 1, it is characterized in that, described electronic installation comprises a data storage element, one receiving element and a processing unit, described data storage element and described receiving element with the mutual data transmission of described processing unit, described data storage element stores a plurality of example weight information, a plurality of sample Raman spectral information and a plurality of sample scattering strength values, described processing unit is by the weight information of thing to be identified thus, the relativeness of Raman spectral information and scattering strength numerical value, minimal square error method and the completely data analysis of restrictive condition minimal square error method, compare a plurality of example weight information in described data storage element, a plurality of sample Raman spectral information and a plurality of sample scattering strength values are carried out baseline correction, subtracting each other of fluorescence spectrum, and data qualitative and quantitative analysis detects the contained chemical substance of thing.
8. pick-up unit according to claim 1, is characterized in that, described mobile platform comprises a plurality of displacement motors, and described a plurality of displacement motors provide the multidirectional displacement of mobile platform and rotation.
9. pick-up unit according to claim 1, it is characterized in that, described adjustment type sampler comprises a plurality of mobile motors and a sampler, described a plurality of mobile motor provides the multidirectional displacement of portable sampler and rotation, and described sampler is quantitative pin, quantitative liquid suction pipe or electronic automatic ration aspirator.
10. a detection method for the chemical substance quantitative and qualitative analysis of intelligent robotization, is characterized in that, described detection method bag is drawn together lower row and walked rapid ︰
Yang product are Dinged Wei ︰ the testing container that is equipped with determinand are put into extraction equipment, described determinand is positioned on weight measurement unit, and by described weight measurement unit, produce weight information, then operating switch part clips perforation group and partly penetrates described testing container;
Rong Ji Chu Li ︰ is by the solvent heating in solvent treating apparatus and be transported to described extraction equipment;
Extraction is got described in ︰ solvent and is flow into and in described testing container, mix with described determinand and produce an extract, extracts dropper the described extract of collection is splashed in collection container;
Solvent evaporates in Nong Suo ︰ heating and the acceleration collection container of blowing is to obtain concentrate;
Fen Xi ︰ adopts adjustment type sampler to draw described concentrate, and be added drop-wise to detect on slide glass and be combined after blow dried with joint portion, after irradiating with light focus control group, read Raman spectrum signal, and be input to electronic installation analysis, described electronic installation analyses and comparison Raman spectrum signal and weight information, analyze chemical substance contained in thing to be detected.
11. detection methods according to claim 10, it is characterized in that, in analytical procedure, described electronic installation is by Raman spectrum signal, the weight information of thing to be detected and be stored in that a plurality of sample Raman spectrum signals in described electronic installation, a plurality of example weight information are compared, the subtracting each other of baseline correction, fluorescence spectrum, data qualitative and quantitative analysis, application minimal square error method and completely the data of restrictive condition minimal square error method analyze the contained chemical substance of thing to be detected.
12. detection methods according to claim 10, it is characterized in that, described smooth focus control group is radiated the first light and the second light, the wavelength of the first light and the second light is very close, while scanning the described thing to be detected of detection with this, produce the first spectrogram and the second spectrogram, fluorescence spectrum subtracts each other the quantitative and qualitative analysis result that obtains detecting dark sample with baseline correction thus, or described smooth focus control group is radiated a far red light, while scanning detection thing to be detected with this, thereby generation does not contain the Raman spectrogram of the noise of fluorescence reaches the quantitative and qualitative analysis result that detects dark sample.
13. detection methods according to claim 10, is characterized in that, in solvent treatment step, by a force (forcing) pump, push heated solvent from described solvent treating apparatus to described extraction equipment, and force (forcing) pump produces 0.1kg/cm 2～1000kg/cm 2the pressure of scope.
14. detection methods according to claim 10, is characterized in that, described solvent is organic solvent, hydrosolvent, mixed solvent or carbon dioxide.
The pick-up unit of the chemical substance quantitative and qualitative analysis of 15. 1 kinds of intelligent robotizations, is characterized in that, described pick-up unit bag is drawn together ︰
One testing container, for storing thing to be detected;
One solvent treating apparatus, for storing and heating pressurized solvent;
One extraction equipment, described extraction equipment comprises an extraction board, one perforation group, one switch member and a weight measurement unit, described extraction board is provided with a positioning part, described extraction board is provided with a sense channel being connected with positioning part and an endpiece being connected with described sense channel, described perforation group activity group is located in described sense channel, described perforation group clips and pierces through described testing container, described switch member hub setting is at described extraction board, and with the setting of described perforation group interlock, described weight measurement unit is corresponding with described positioning part, and group is located at sense channel, described endpiece is connected with described sense channel, the solvent having heated imports in sense channel from pipeline, and dissolve the deposits yields extract to be detected in testing container through described perforation group, a weight information is exported in described weight measurement unit,
One pipeline, the sense channel of solvent treating apparatus and described extraction equipment described in described pipeline connection;
One test tubes, described test tubes group is located at endpiece and is connected with described sense channel, is equipped with a joint portion in described test tubes, and extract passes into described test tubes and is combined with described joint portion;
One detecting unit, described detecting unit comprises a smooth focus control group, described smooth focus control group throw light reads a Raman spectrum signal behind described joint portion;
One electronic installation, described electronic installation and described solvent treating apparatus, described extraction equipment, described detecting unit electrically connect, described electronic installation receives Raman spectrum signal, and analyze Raman spectrum signal, to obtain the contained chemical substance information in thing that detects, described electronic installation receives weight information;
Thus, by described solvent treating apparatus and described extraction equipment, obtain concentrate, and after being combined by the molecule of described concentrate and the joint portion of described test tubes, by described smooth focus control group, read weight information that Raman spectrum signal and weight measurement unit provide to described electronic installation, described electronic installation is compared and is analyzed by analytic unit after the weight information and Raman spectrum signal of thing to be detected, reconfigure the chemical substance of thing to be detected, to reach the effect of quantitative and qualitative analysis thing to be detected.
16. pick-up units according to claim 15, it is characterized in that, described solvent treating apparatus comprises a force (forcing) pump, a reservoir, a heating chamber being connected with described reservoir and described sense channel, described pipeline comprises one first pipeline and one second pipeline, force (forcing) pump and described sense channel described in described the first pipeline connection, reservoir and described sense channel described in described the second pipeline connection, and on described the first pipeline, be provided with one first valve, on described the second pipeline, be provided with one second valve.
17. pick-up units according to claim 15, it is characterized in that, described perforation group comprises two needle tubing sheets that are oppositely arranged, described in each, the shape of needle tubing sheet and the structure of described testing container are corresponding, described in each, one end mask of needle tubing sheet has a plurality of needle tubings, when two needle tubing sheets clip the both sides of described testing container, described in each, a plurality of needle tubings of needle tubing sheet can penetrate in testing container.
18. according to pick-up unit described in claim 15, it is characterized in that, the described joint portion of described test tubes is surface reinforced Raman active carrier, the colloidal sol body that described surface reinforced Raman active carrier is metallic particles.
19. pick-up units according to claim 18, it is characterized in that, described smooth focus control group comprises a light supply apparatus and a spectrometer, described light supply apparatus can project laser light, ultraviolet light, near infrared light, far red light or visible ray, described light supply apparatus comprises a body, one light emitting source, one goes out shaven head, one group goes out bare headed focus regulating mechanism described in being located at, described light emitting source group is located at described intrinsic one end, described light emitting source projects the light of at least one wavelength, and produce at least one projecting light path and at least one backhaul light path, describedly go out the bare headed group of other end that is located at described body, it is described that to go out shaven head corresponding with the described joint portion of described test tubes,
Described at least one projecting light path finally goes out shaven head to the described joint portion of described test tubes by described through one first collimation lens, a laser rays filtrator, a colo(u)r filter, a beam splitter in order, described at least one projecting light path arrives one first focusing light path of the joint portion of described test tubes by described beam splitter in beam splitter generation one, by the second focusing light path of described beam splitter reflection, described the second focusing light path projects by one second focus lamp to one group of photosensory assembly that is located at described body with one;
Described in described at least one return light route, detect the joint portion of slide glass in order through going out shaven head, colo(u)r filter, a reflector plate, one second collimation lens and one group of long pass light filter that is located at inner body wall, described long pass light filter and described spectrometer are electrically connected;
Described focus regulating mechanism, described photosensory assembly and described spectrometer and described electronic installation are electrically connected;
The difference of the path of described electronic installation comparison the first focusing light path and the path of the second focusing light path, goes out bare headed burnt section described in automatically adjusting by described focus regulating mechanism, to go out the focal length of shaven head and described test tubes described in adjusting.
20. pick-up units according to claim 19, it is characterized in that, described pick-up unit also comprises a light focus control device being electrically connected with described light emitting source, described light emitting source is provided with at least two luminescent grains, described smooth focus control device regulates and controls luminance and the emission wavelength of arbitrary luminescent grain, make described light emitting source project the light of at least one wavelength, and control wavelength, power, light intensity and the shinny state of luminescent grain.
21. pick-up units according to claim 15, is characterized in that, described smooth focus control group is provided with a rotation motor, and described rotation motor drives described light supply apparatus displacement.
The detection method of the chemical substance quantitative and qualitative analysis of 22. 1 kinds of intelligent robotizations, is characterized in that, described detection method bag is drawn together lower row and walked rapid ︰
Yang product are Dinged Wei ︰ the testing container that determinand is housed are put into extraction equipment, and then operating switch part makes perforation group clip described testing container and part penetrates described testing container;
Rong Ji Chu Li ︰ is by the solvent heating in solvent treating apparatus and be pressed and delivered to extraction equipment;
Extraction is got described in ︰ solvent and is flow into and in described testing container, mix generation one extract with described determinand;
Described in Fen Xi ︰, extract is delivered to test tubes by endpiece, molecule in described extract is combined with joint portion, after heating and blow dried, by light focus control group, read a Raman spectrum signal, and be input to electronic installation analysis, described electronic installation comparison Raman spectrum signal and weight information are analyzed contained chemical substance in described thing to be detected.
23. detection methods according to claim 22, it is characterized in that, in analytical procedure, described electronic installation is by Raman spectrum signal, the weight information of thing to be detected and be stored in that a plurality of sample Raman spectrum signals in described electronic installation, a plurality of example weight information are compared, the subtracting each other of baseline correction, fluorescence spectrum, data qualitative and quantitative analysis, application minimal square error method and completely the data of restrictive condition minimal square error method analyze the contained chemical substance of thing to be detected.
24. detection methods according to claim 22, it is characterized in that, described smooth focus control group is radiated the first light and the second light, the wavelength of described the first light and described the second light is close, while scanning detection thing to be detected with this, produce the first spectrogram and the second spectrogram, fluorescence spectrum subtracts each other the quantitative and qualitative analysis result that obtains detecting dark fluorescent radiation sample with baseline correction thus, or described smooth focus control group is radiated a far red light, while scanning detection thing to be detected with this, thereby generation does not contain the Raman spectrogram of the noise of fluorescence reaches the quantitative and qualitative analysis result that detects dark sample.
25. detection methods according to claim 22, is characterized in that, in Sample location step, the weight data of determinand is measured in described electronic installation in weight measurement unit.
26. detection methods according to claim 22, is characterized in that, in solvent treatment step, open one second valve and make the solvent in a reservoir be sent to heating chamber heating.
27. detection methods according to claim 22, is characterized in that, described solvent is organic solvent, water, mixed solvent or carbon dioxide.
28. detection methods according to claim 22, is characterized in that, in extraction step, open the first valve the gas in force (forcing) pump is flow in sense channel, and push described solvent in described testing container, finally in described test tubes.
29. detection methods according to claim 28, is characterized in that, in solvent treatment step, the air pressure of the gas that described force (forcing) pump is sent is 0.1kg/cm 2～1000kg/cm 2.
The pick-up unit of 30. 1 kinds of intelligent automatic chemistry material quantitative and qualitative analysis, is characterized in that, described pick-up unit bag is drawn together ︰
One testing container, for storing thing to be detected;
One solvent treating apparatus, for storage, heating and pressurized solvent;
One extraction equipment, described extraction equipment comprises an extraction board, one perforation group, one switch member, one weight measurement unit and an extraction dropper, described extraction board is provided with a positioning part, and in described extraction board, be provided with a sense channel being connected with described positioning part, described perforation group activity group is located in described sense channel, described switch member and the setting of described perforation group interlock, described weight measurement unit is corresponding with described positioning part, and group is located at described sense channel, described extraction dropper group is located at the end of described extraction board and is connected with described sense channel, described extraction dropper is provided with a titration end, solvent is mixed to form extract via described extraction equipment and thing to be detected, a weight information is exported in described weight measurement unit,
One pipeline, the described sense channel of solvent treating apparatus and described extraction equipment described in described pipeline connection;
One enrichment facility, described enrichment facility comprises a mobile platform and an inspection instrument, described mobile platform is provided with a heating part, described inspection instrument is seated in described heating part, in described inspection instrument, there is a joint portion, described extract is in described inspection instrument, and through heating and air blowing simmer down to concentrate, the molecule in described concentrate is combined with described joint portion;
One detecting unit, described detecting unit comprises a smooth focus control group, described smooth focus control group comprises a light supply apparatus, one end of described light supply apparatus is provided with one and goes out shaven head, describedly go out shaven head and wear described mobile platform and corresponding with the joint portion of inspection instrument, described smooth focus control group throw light reads a Raman spectrum signal behind described joint portion;
One electronic installation, described electronic installation and described solvent treating apparatus, described extraction equipment, described enrichment facility, described detecting unit electrically connect, described electronic installation receives Raman spectrum signal and carrys out chemical substance contained in analyzing and testing thing, and simultaneously described electronic installation receives weight information.
31. pick-up units according to claim 30, it is characterized in that, described solvent treating apparatus comprises the reservoir of a storage of solvent, the heating chamber of one heated solvent, two solenoid valves and a force (forcing) pump being connected with described heating chamber, described pipeline comprises a front pipeline and a rear pipeline, reservoir and described heating chamber described in described front pipeline connection, heating chamber and described sense channel described in described rear pipeline connection, described two solenoid valves respectively group are located on described front pipeline and described rear pipeline, by described two solenoid valves, adjusting described reservoir and described heating chamber and described heating chamber and described sense channel is conducting state or hinders but state, described force (forcing) pump is as pressurization and push the function of described solvent.
32. pick-up units according to claim 30, it is characterized in that, described perforation group comprises two needle tubing sheets that are oppositely arranged, the shape of each needle tubing sheet is corresponding with the structure of described testing container, one end mask of each needle tubing sheet has a plurality of needle tubings, when two needle tubing sheets clip the both sides of described testing container, a plurality of needle tubings of each needle tubing sheet can penetrate in described testing container.
33. pick-up units according to claim 30, is characterized in that, the described joint portion of described inspection instrument is surface reinforced Raman active carrier, the colloidal sol body that described surface reinforced Raman active carrier is metallic particles.
The pick-up unit of the chemical substance quantitative and qualitative analysis of 34. intelligent robotizations according to claim 30, it is characterized in that, described smooth focus control group comprises a light supply apparatus and a spectrometer, described light supply apparatus projection laser light, ultraviolet light, near infrared light, far red light or visible ray, described light supply apparatus comprises a body, one light emitting source, one goes out shaven head, one group goes out bare headed focus regulating mechanism described in being located at, described light emitting source group is located at intrinsic one end, described light emitting source projects the light of at least one wavelength, and produce at least one projecting light path and at least one backhaul light path, describedly go out the bare headed group of other end that is located at described body, it is described that to go out shaven head corresponding with described detection slide glass,
Described at least one projecting light path finally goes out shaven head to the described joint portion of described detection slide glass by described through one first collimation lens, a laser rays filtrator, a colo(u)r filter, a beam splitter in order, described projecting light path arrives one first focusing light path of described detection slide glass by beam splitter in described beam splitter generation one, by the second focusing light path of described beam splitter reflection, described the second focusing light path projects by one second focus lamp to one group of photosensory assembly that is located at described body with one;
Described in described at least one return light route, detect the described joint portion of slide glass in order through going out shaven head, colo(u)r filter, a reflector plate, one second collimation lens and one group of long pass light filter that is located at described inner body wall, described long pass light filter and described spectrometer are electrically connected;
Described focus regulating mechanism, described photosensory assembly and described spectrometer and described electronic installation are electrically connected;
The difference of the path of described electronic installation comparison the first focusing light path and the path of the second focusing light path, goes out bare headed burnt section described in adjusting by described focus regulating mechanism is automatic, goes out the focal length of shaven head and described inspection instrument described in adjusting.
35. pick-up units according to claim 34, it is characterized in that, described pick-up unit also comprises a light focus control device being electrically connected with described light emitting source, described light emitting source is provided with at least two luminescent grains, luminance and the emission wavelength of the arbitrary described luminescent grain of described smooth focus control device regulation and control, make described light emitting source project the light of at least one wavelength, and control wavelength, power, light intensity and the shinny state of described luminescent grain.
36. pick-up units according to claim 30, it is characterized in that, described electronic installation comprises a data storage element, one receiving element and a processing unit, described data storage element and described receiving element and the mutual data transmission of described processing unit, described data storage element stores a plurality of example weight information, a plurality of sample Raman spectral information and a plurality of sample scattering strength values, described processing unit is by the weight information of thing to be identified thus, the relativeness of Raman spectral information and scattering strength numerical value, minimal square error method and the completely data of restrictive condition minimal square error method are analyzed, compare a plurality of example weight information in described data storage element, a plurality of sample Raman spectral information and a plurality of sample scattering strength values are carried out baseline correction, subtracting each other of fluorescence spectrum, and described in data qualitative and quantitative analysis, detect the contained chemical substance of thing.
The detection method of the chemical substance quantitative and qualitative analysis of 37. 1 kinds of intelligent robotizations, is characterized in that, described detection method bag is drawn together lower row and walked rapid ︰
Yang product are Dinged Wei ︰ the testing container that is equipped with determinand are put in extraction equipment, described determinand is positioned on weight measurement unit, described weight measurement unit produces a weight information, and then operating switch part clips perforation group and partly penetrates described testing container;
Rong Ji Chu Li ︰ heats the solvent in solvent treating apparatus and pressurizes and be transported to described extraction equipment;
Extraction is got ︰ solvent and is flow in described testing container and mix with determinand and produce an extract, and described extraction dropper splashes into the extract of collection in described inspection instrument;
Extract in Nong Suo ︰ heating and the described inspection instrument of blowing, makes solvent evaporates obtain a concentrate;
Fen Xi ︰ light focus control group is irradiated behind the joint portion of described inspection instrument, read Raman spectrum signal, and be input to electronic installation analysis, described electronic installation analyses and comparison Raman spectrum signal and weight information, analyze chemical substance contained in thing to be detected.
38. according to the detection method described in claim 37, it is characterized in that, in analytical procedure, described electronic installation is by Raman spectrum signal, the weight information of thing to be detected and be stored in that a plurality of sample Raman spectrum signals wherein, a plurality of example weight information are compared, the subtracting each other of baseline correction, fluorescence spectrum, data qualitative and quantitative analysis, application minimal square error method and completely the data of restrictive condition minimal square error method analyze the contained chemical substance of thing to be detected.
39. according to the detection method described in claim 37, it is characterized in that, described smooth focus control group radiation one first light and one second light, the wavelength of the first light and the second light is close, while detecting thing to be detected by scanning, produce the first spectrogram and the second spectrogram, with this fluorescence spectrum, subtract each other the quantitative and qualitative analysis result that obtains detecting dark fluorescent radiation sample with baseline correction, or described smooth focus control group is radiated a far red light, while detecting described thing to be detected by scanning, thereby generation does not contain the Raman spectrogram of the noise of fluorescence reaches the quantitative and qualitative analysis result that detects dark sample.
40. according to the detection method described in claim 37, it is characterized in that, in solvent treatment step, with force (forcing) pump, pushes heated solvent from described solvent treating apparatus to described extraction equipment, and described force (forcing) pump produces 0.1kg/cm 2～1000kg/cm 2the pressure of scope.
41. according to the detection method described in claim 40, it is characterized in that, described solvent is organic solvent, hydrosolvent, mixed solvent or carbon dioxide.
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