CN103630524B - The detection device of the chemical substance quantitative and qualitative analysis of intelligent type automatic - Google Patents

The detection device of the chemical substance quantitative and qualitative analysis of intelligent type automatic Download PDF

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CN103630524B
CN103630524B CN201310471120.5A CN201310471120A CN103630524B CN 103630524 B CN103630524 B CN 103630524B CN 201310471120 A CN201310471120 A CN 201310471120A CN 103630524 B CN103630524 B CN 103630524B
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detection
group
electronic installation
light
solvent
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CN103630524A (en
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杨建夫
汪克毅
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Abstract

The present invention provides the detection device of the chemical substance quantitative and qualitative analysis of a kind of intelligent type automatic, and described detection device comprises a testing container, a solvent treating unit, an extraction plant, a pipeline, a concentrating unit, a detecting unit and an electronic installation. Determinand is placed in described testing container by the present invention, and by described solvent treating unit, described extraction plant, described concentrating unit, described detecting unit and described electronic installation, by fast qualitative and quantitative in the way of, detect out the chemical substance contained by described determinand. The detection device of the chemical substance quantitative and qualitative analysis of intelligent type automatic provided by the invention, reach the effect of quantitative and qualitative analysis thing to be detected, provide operate fast and easily, full-automaticization and highly sensitive detection function, allow the chemical substance that user can detect described thing to be detected fast and comprises, and reach product pipe and the qualitative and quantitative effect of detection.

Description

The detection device of the chemical substance quantitative and qualitative analysis of intelligent type automatic
Technical field
The present invention relates to the detection device of the chemical substance quantitative and qualitative analysis of a kind of intelligent type automatic, specifically, it relates to a kind of ease of Use and detection time is short and detection sensitivity is high test set and method.
Background technology
Food is the requisite maintaining physical function and metabolism, and it is normally made up of carbohydrate, fat, protein or water. Food, except maintaining except physical function, also can affect the mood of people, such as, containing by bringing people the material of joyful sense in some food. Along with the raising of quality of life, work is also relative busy, the pressure of people is caused to become big gradually, therefore nowadays food concerning people not exclusively just pursuit have enough to eat and wear and with, the substitute is and enjoy happiness and the happy feeling that cuisines bring, therefore nowadays catering trade prosperity especially, various snack bars and drinks also emerges in an endless stream, and makes people have more preference for food.
Science and technology constantly improves; also driven the prosperity of food-processing industry simultaneously; in order to meet the demand in market; natural food process can be become the food with higher commercial value by relevant industries; wherein may add chemical substance in food; in addition, food can be convenient for people to preserve by packaging usually, but the chemical substance in packaging easily attaches on food. But, if people eat too much chemical additive can affect physical function, cause disease to be burdened with. Substantially, people are when buying food, and the chemical substance that cannot directly remain on food by being observed visually, can only rely on the conscience with industry of checking on of government. Still have unsafe food unavoidably commercially to peddle and eaten by mistake by human consumer, such as poison milk trimeric cyanamide and fluidizer storm, some manufacturers are in order to pursue low cost, in legal food additives (mist generating agent), it may also be useful to cheap industrial plastics agent, the scope of its impact is very extensive, such as beverage, bread, cake even medicine etc., if accidentally eating the food with fluidizer by mistake, not only causing reproductive system pathology, even having carcinogenic danger.The poisonous additive event of food is constantly broken out such as poison milk event (trimeric cyanamide in China and Taiwan in recent years, fluidizer, clenbuterol hydrochloride), the carcinogenic soy sauce of single propylene glycol of chlorine, the malicious bar of maleic acid, steroid (betamethasone), diuretic(s) (hydrochlorothiazide), the pigeon feed additives such as cardiotonic drug (caffeine), Tianjin poison boiled dumpling event and the Environmental Hormone not yet broken out, aquaculture, electric consumers, toy, daily necessities, makeup, agricultural-food, etc., cause people common people's uneasiness and the attention to food test, rush to purchase milk tide fear thus arouse the thorough inspection consciousness of Liao Ge manufacturer, adding that farm crop use agricultural chemicals in a large number, agricultural-food are contained Pesticides Testing control pay attention to day by day by agriculture political affairs unit, aquaculture feed is again and again toxic, outlet is caused to be obstructed, rivers and creeks, various countries ecology is subject to polluting to be destroyed, the more urgent strict reason implementing inspection etc. of environmental monitoring control, the purposes proceeding to industrial community production control that fast and convenient detecting instrument is comprehensive, and check sensitivity requirement more and more to be developed toward the direction of trace and the needs of reliability.
In addition, nowadays sick edible medicine and safeguard that the protective foods of physiological function all commercially passes through widely, before each similar drug commercially circulates, pharmaceutical factory can first carry out strict detection, to check the composition of medicine whether correct, carries out last checking on.
In daily life, human consumer often faces the puzzlement having bought fake products, fake wine, and government and manufacturer check on difficulty, and human consumer has the needs detected voluntarily.
General technology of knowing checks the composition in food and medicine with gas chromatography mass spectrometry instrument (GC) or high performance liquid chromatography (HPLC), wherein the shortcoming of gas chromatography mass spectrometry instrument (GC) is to need to lose time to increase the volatility analyzing thing, and then cause the interference in analysis process and increase quantitative degree of difficulty, the difference that high performance liquid chromatography (HPLC) is the interaction utilizing chemistry in preparation process or physical properties carrys out separating mixture. When using high performance liquid chromatography, liquid thing to be detected is injected into chromatographic column at one time, mainly according to various thing to be detected by being caused the difference of the residence time to reach separating effect in the gap of dynamic phase and the interaction strength of stationary phase during chromatographic column, the signal induction intensity of each material obtained finally by detector to detect contained material, like this its analysis time long (generally about more than one, two week) and flow process is loaded down with trivial details. And high performance liquid chromatography by detector such as UV-detector and cannot the character of identification sample. In addition, physical environment can be caused that very big harm, operation are strict, method exploitation is remarkable and time-consuming by high performance liquid chromatography (HPLC) equipment and required running stores a large amount of toxic organic solvents waste material expensive, that produce. Therefore, above-mentioned two kinds of equipment need to be subject to the training operating machine and had the talent of application experience can should be used for checking the composition of food and medicine fast, for pharmaceutical factory, owing to above-mentioned disappearance also causes pharmaceutical production cost higher.
In order to overcome above-mentioned defect, the present inventor drops into the much time and carries out correlative study, and add and compare every quality, carry out the research and development of related products, thus release the present invention's [detection device of the chemical substance quantitative and qualitative analysis of intelligent type automatic.
Summary of the invention
In order to overcome the defect of prior art, main purpose of the present invention is to provide a kind of ease of Use, reach (0.1 second was by several minutes) and a large amount of composition analyzing toxic chemical solvent in determinand fast, promote the sensitivity and accuracy of analyzing detection, wherein determinand is medicine, pharmaceutical raw material, food, food contamination, Environmental Hormone, explosive, virus, cancer biological marker, true and false article identification, true wine fake wine identification etc., it is possible to promote the sensitivity and accuracy of analyzing detection.
In order to realize above-mentioned purpose and effect, the present invention provides the first embodiment of the detection device of the chemical substance quantitative and qualitative analysis of a kind of intelligent type automatic, and described detection device comprises a testing container, for storing thing to be detected, one solvent treating unit, for storage, heating and pressurized solvent, one extraction plant, described extraction plant comprises an extracter platform, one perforation group, one switch member, one weight measurement unit and an extraction dropper, described extracter platform is provided with a positioning part, and in described extracter platform, it is provided with a detection passage being connected with described positioning part, described perforation group activity group is located in described detection passage, described perforation group clips and pierces through described testing container, described switch member is hubbed on described extraction plant, and arrange with described perforation group is even dynamic, described weight measurement unit is corresponding with described positioning part, and group is located at described detection passage, described extraction dropper group is located at the end of described extracter platform, and it is connected with described detection passage, described extraction dropper is provided with a titration end, described solvent is mixed to form extraction liquid via described extracter platform and described thing to be detected, described weight measurement unit exports a weight information, the described detection passage of one pipeline, solvent treating unit described in described pipeline connection and described extraction plant, one concentrating unit, described concentrating unit comprises a mobile platform and a collection container, described mobile platform is provided with a heating part, and described collection container is placed on described heating part, and by heat and extract dropper blow mode by extraction liquid simmer down to concentrated solution, one detecting unit, described detecting unit comprises a sampler, a smooth focus control group and a detection slide glass, described detection slide glass group is located on described mobile platform, the end face of described detection slide glass is provided with a joint portion, the molecule of described joint portion in described concentrated solution is combined, and reads a Raman spectrum signal after described smooth focus control group throw light, one electronic installation, described electronic installation and described solvent treating unit, described extraction plant, described concentrating unit, described detecting unit electrically link, described electronic installation receives described Raman spectrum signal to analyze chemical substance contained in described detection thing, and described electronic installation receives described weight information simultaneously.
Thus, after the molecule of described concentrated solution is combined with described detection slide glass, reading the highest Raman spectrum signal by described smooth focus control group provides weight information to described electronic installation by described weight measurement unit, after described electronic installation carries out the weight information of thing to be detected and the compare of analysis of Raman spectrum signal, again the chemical substance of thing to be detected is combined, reach the effect of quantitative and qualitative analysis thing to be detected like this, offer fast and operates easily, full-automaticization and highly sensitive detection function, allow the chemical substance that user can detect described thing to be detected fast and comprises, and reach product pipe and detect qualitative and quantitative effect.
Preferably, the first embodiment of the present invention also comprises following technology feature, described solvent treating unit comprises the reservoir of a storage of solvent, the heating chamber of one heated solvent, two magnetic valves and a force (forcing) pump being connected with heating chamber, described pipeline comprise one before pipeline and one after pipeline, reservoir and described heating chamber described in described front pipeline connection, heating chamber described in described rear pipeline connection and described detection passage, described two magnetic valves respectively group be located on described front pipeline and described rear pipeline, adjust described reservoir and described heating chamber and described heating chamber and described detection passage by two magnetic valves to be conducting state or hinder but state, described force (forcing) pump is as the effect pushing described solvent. more preferably, the further technology feature of the first embodiment of the present invention, perforation group described in this comprises two needle tubing sheets being oppositely arranged, the shape of each needle tubing sheet is corresponding with the structure of described testing container, described in each, the end face of needle tubing sheet has multiple needle tubing, when two needle tubing sheets clip the both sides of described testing container, multiple needle tubings of needle tubing sheet described in each can be worn in described testing container.
More preferably, the first embodiment of the present invention also comprises following technology feature, the described joint portion of described detection slide glass is surface reinforced Raman active carrier (SERS-activesubstrate), described surface reinforced Raman active carrier is the sol of metallic particles, the surface of described joint portion is provided with a Raman spectrum optically focused focus sheet, described Raman spectrum optically focused focus sheet be silicon chip or other draw graceful unit spectrum standard specimen, supply the application that optically focused focus sets, and concentrated solution restriction ring (RetainingRing) it is provided with in periphery, described joint portion, the material of described concentrated solution restriction ring is paraffin ring or Te Folong (Teflon), to limit homogeneity and the reliability that concentrated solution drips to the scope detecting slide glass and keeps concentrated solution to distribute.
Preferably, described smooth focus control group comprises a light source device and a spectrograph, described light source device can project laser light, UV-light (UV), near infrared light (NearInfrared:NIR), far red light (FarInfrared:FIR) or visible ray, described light source device comprises a body, one luminous source, one goes out shaven head, one group be located at described in go out shaven head described focus regulating mechanism, one end that described luminous source group is located in described body, described luminous source projects the light of at least one wavelength, and produce at least one projecting light path and at least one backhaul light path, described bright dipping head group is located at the other end of described body, described go out shaven head corresponding with described detection slide glass, described at least one projecting light path in order by one first collimating lens, a laser rays strainer, spectral filter of the same colour, a beam splitter finally by described go out shaven head to the described joint portion of described detection slide glass, described projecting light path described beam splitter produce one by described beam splitter to described detection slide glass one first focus light path, with a 2nd focusing light path reflected by described beam splitter, described 2nd focusing light path is projected through the photosensory assembly that one the 2nd condensing lens is located at described body to a group, the described joint portion detecting slide glass described at least one return light route goes out shaven head, described look spectral filter, a reflector plate, one the 2nd collimating lens and one group of long pass spectral filter being located at described inner body wall described in process in order, and described long pass spectral filter and described spectrograph are electrically connected, described focus regulating mechanism, described photosensory assembly and described spectrograph and described electronic installation are electrically connected, described electronic installation comparison first is focused the difference of path length of the path length of light path and the 2nd focusing light path, by going out the burnt section of shaven head with described detection slide glass described in the adjustment of described focal length automatic adjusting machine structure, goes out the focal length of shaven head described in adjusting.
More preferably, the technology feature of the first embodiment of the present invention also comprises a light focus control device being electrically connected with luminous source, described luminous source is provided with at least two luminous crystal grain, the luminous state of the arbitrary described luminous crystal grain of described smooth focus control device regulation and control and emission wavelength, make described luminous source project the light of at least one wavelength, and control the wavelength of luminous crystal grain, power, light intensity and shinny state.
More preferably, the first embodiment of the present invention also comprises technology feature, described electronic installation comprises a data storage element, one reception unit and a processing unit, described data storage element and described reception unit and the mutual transfer of described processing unit, described data storage element stores multiple example weight information, multiple sample Raman spectral information and multiple sample scattering strength values, thus described processing unit is by the weight information of thing to be identified, the relative relation of Raman spectral information and scattering strength numerical value, the data analysis of minimal square error method (LeastSquareMethod) and complete restricted condition minimal square error method (FullConstrainedLeastSquareMethod), multiple example weight information in data storage element described in comparison, multiple sample Raman spectral information and multiple sample scattering strength values carry out baseline correction, subtracting each other of fluorescence spectrum, and data quantitative and qualitative analysis analysis detects the chemical substance contained by thing.
Preferably, the first embodiment of the present invention also comprises following technology feature, and described mobile platform comprises multiple displacement motor, and described multiple displacement motor provides described mobile platform many to displacement and rotation; Preferably, described sampler comprises multiple mobile motor and a sampler, described mobile motor provides described sampler many to displacement and rotation, and described sampler is quantitative pin (Syringe), quantitative liquid suction pipe (Pipette) or electronic automatic ration imbibition device (MotorizedAuto-Pipette).
Preferably, first embodiment of the detection method of the chemical substance quantitative and qualitative analysis of a kind of intelligent type automatic of the present invention, described detection method comprises the following steps that equipment is had the described testing container of determinand to put into described extraction plant by Sample location, described determinand is positioned on described weight measurement unit, and by described weight measurement unit produce weight information, then operate described switch member make described perforation group clip and part wear into described testing container; Solvent process is by the described solvothermal (10 DEG C to 200 DEG C) in described solvent treating unit and pressurization (0.1kg/cm2To 1000kg/cm2) and be transported to described extraction plant; Extracting described solvent to be flowed in described testing container with described determinand to mix and produce an extraction liquid, the described extraction drop of collection is entered in described collection container by described extraction dropper; Concentrated heating and the described solvent blown in described acceleration collection container are waved thus are sent out and obtain concentrated solution; Analyze described sampler and draw described concentrated solution, and it is added drop-wise on described detection slide glass after described joint portion is in conjunction with blow dried, Raman spectrum signal is read after irradiating with described smooth focus control group, and it is input to described electronic installation to analyze, described electronic installation analyses and comparison Raman spectrum signal and weight information, analyze chemical substance contained in thing to be detected.
Preferably, first embodiment of the detection method of the chemical substance quantitative and qualitative analysis of a kind of intelligent type automatic of the present invention also comprises following technology feature, in described analytical procedure, described electronic installation is by the Raman spectrum signal of described thing to be detected, weight information and the multiple sample Raman spectrum signals being stored in described electronic installation, multiple example weight information is compared, baseline correction, subtracting each other of fluorescence spectrum, data quantitative and qualitative analysis is analyzed, the data of application minimal square error method (LeastSquareMethod) and complete restricted condition minimal square error method (FullConstrainedLeastSquareMethod) analyze the chemical substance contained by thing to be detected.
Preferably, the first embodiment of the present invention is technology feature also, described smooth focus control group radiates the first light and the 2nd light, the wavelength of described first light and described 2nd light is close, with described in this Scanning Detction during thing to be detected, produce the first spectrogram and the 2nd spectrogram, thus fluorescence spectrum subtracts each other the quantitative and qualitative analysis result obtaining detecting dark sample with baseline correction, or described smooth focus control group radiates a far red light, during thing to be detected with this Scanning Detction, produce not contain the Raman spectrogram of the noise of fluorescence thus reach the quantitative and qualitative analysis result that can detect dark sample.
Preferably, the further technology feature of the first embodiment of the present invention, in solvent treatment step, a force (forcing) pump push heated solvent from described solvent treating unit to described extraction plant, described force (forcing) pump produce 0.1kg/cm2��1000kg/cm2The pressure of scope. Preferably, described solvent is organic solvent, water solvent, mixed solvent or carbonic acid gas.
Preferably, the 2nd embodiment of the detection device of the chemical substance quantitative and qualitative analysis of the intelligent type automatic of the present invention, described detection device comprises a testing container, for storing thing to be detected, one solvent treating unit, for storage also solvent described in heating and pressurizing, one extraction plant, described extraction plant comprises an extracter platform, one perforation group, one switch member and a weight measurement unit, described extracter platform is provided with a positioning part, described extracter platform is provided with a detection passage being connected with positioning part and an exit end being connected with described detection passage, described perforation group activity group is located in described detection passage, described perforation group clips and pierces through described testing container, described switch member is hubbed on described extracter platform, and arrange with described perforation group is even dynamic, described weight measurement unit is corresponding with described positioning part, and group is located at described detection passage, described exit end is connected with described detection passage, the described solvent heated imports in described detection passage from described pipeline, and dissolve the raw extraction liquid of the produce described to be detected in described testing container through described perforation group, described weight measurement unit exports a weight information,One pipeline, the detection passage of solvent treating unit and described extraction plant described in described pipeline connection; One test tubes, described test tubes group is located at described exit end and is connected with described detection passage, and a joint portion is put in described test tubes inner ring winding, and described extraction liquid leads to and is combined with described joint portion into described test tubes; One detecting unit, described detecting unit comprises a smooth focus control group, reads setting and detection thing Raman spectrum signal that a Raman spectrum signal does the strongest signal focal length after described smooth focus control group throw light to described joint portion; One electronic installation, described electronic installation and described solvent treating unit, described extraction plant, described detecting unit electrically link, described electronic installation receives described Raman spectrum signal, and analyze described Raman spectrum signal, obtaining chemical substance information contained in described detection thing, described electronic installation receives described weight information.
Thus, concentrated solution is obtained by described solvent treating unit and described extraction plant, and after being combined with the described joint portion of described test tubes by the molecule of concentrated solution, the weight information provided by described smooth focus control group reading Raman spectrum signal and weight measurement unit is to described electronic installation, described electronic installation is by after analytical unit comparison and the described weight information analyzing thing to be detected and Raman spectrum signal, again the chemical substance of thing to be detected is combined, reach the effect of quantitative and qualitative analysis thing to be detected, offer fast and operates easily, full-automaticization and highly sensitive detection function, allow the chemical substance that user can detect thing to be detected fast and comprises, and reach the effect of product pipe and detection.
Preferably, 2nd embodiment of the detection device of the chemical substance quantitative and qualitative analysis of the intelligent type automatic of the present invention also comprises following technology feature, described solvent treating unit comprises a force (forcing) pump, one reservoir, one heating chamber being connected with described detection passage with described reservoir, described pipeline comprises one first pipeline and one the 2nd pipeline, described first pipeline connection force (forcing) pump and described detection passage, reservoir and described detection passage described in described 2nd pipeline connection, and on described first pipeline, it is provided with one first valve, described 2nd pipeline is provided with one the 2nd valve.
Preferably, 2nd embodiment of the detection device of the chemical substance quantitative and qualitative analysis of the intelligent type automatic of the present invention also comprises following technology feature, described perforation group comprises two needle tubing sheets being oppositely arranged, the shape of each needle tubing sheet is corresponding with the structure of described testing container, the end face of each needle tubing sheet has multiple needle tubing, when two needle tubing sheets clip the both sides of described testing container, multiple needle tubings of each needle tubing sheet can be worn in testing container.
Preferably, 2nd embodiment of the detection device of the chemical substance quantitative and qualitative analysis of the intelligent type automatic of the present invention also comprises following technology feature, the described joint portion of described test tubes is surface reinforced Raman active carrier (SERS-activesubstrate), and described surface reinforced Raman active carrier is the sol of metallic particles.
Preferably, 2nd embodiment of the detection device of the chemical substance quantitative and qualitative analysis of the intelligent type automatic of the present invention also comprises following technology feature, described smooth focus control group comprises a light source device and a spectrograph, described light source device can project laser light, UV-light (UV), near infrared light (NearInfrared:NIR), far red light (FarInfrared:FIR) or visible ray, described light source device comprises a body, one luminous source, one goes out shaven head, one group be located at described in go out shaven head focus regulating mechanism, one end that described luminous source group is located in described body, described luminous source projects the light of at least one wavelength, and produce at least one projecting light path and at least one backhaul light path, described bright dipping head group is located at the other end of described body, described go out shaven head corresponding with the described joint portion of described test tubes,Described at least one projecting light path in order through one first collimating lens, a laser rays strainer, spectral filter of the same colour, a beam splitter finally by described go out shaven head to the described joint portion of described test tubes, at least one projecting light path described beam splitter produce one by described beam splitter to described test tubes described joint portion one first focus light path, with a 2nd focusing light path reflected by described beam splitter, described 2nd focusing light path is projected through the photosensory assembly that one the 2nd condensing lens is located at described body to a group; The described joint portion of test tubes described in described at least one return light route goes out shaven head, described look spectral filter, a reflector plate, one the 2nd collimating lens and one group of long pass spectral filter being located at described inner body wall described in passing through in order, and described long pass spectral filter and described spectrograph are electrically connected; Described focus regulating mechanism, described photosensory assembly and described spectrograph and described electronic installation are electrically connected; Described electronic installation comparison first is focused the difference of path length of the path length of light path and the 2nd focusing light path, automatically the burnt section of shaven head is gone out by described focus regulating mechanism described in being adjusted, to go out the focal length of the described joint portion of shaven head with described test tubes described in adjusting.
Preferably, 2nd embodiment of the detection device of the chemical substance quantitative and qualitative analysis of the intelligent type automatic of the present invention also comprises following technology feature, described detection device also comprises a light focus control device being electrically connected with described luminous source, described luminous source is provided with at least two luminous crystal grain, the luminous state of the arbitrary described luminous crystal grain of described smooth focus control device regulation and control and emission wavelength, make described luminous source project the light of at least one wavelength, and control the wavelength of luminous crystal grain, power, light intensity and shinny state. Preferably, described smooth focus control group is provided with a rotation motor, and described rotation motor drives described light source device displacement.
Preferably, 2nd embodiment of the detection method of the chemical substance quantitative and qualitative analysis of the intelligent type automatic of the present invention, described detection method comprises the following steps that the testing container that determinand is housed is put into extraction plant by Sample location, and then operating switch part makes perforation group clip described testing container and partly wear into described testing container; Solvent process by the solvothermal in solvent treating unit and is pressed and delivered to extraction plant; Extraction solvent is flowed in described testing container to mix with determinand produce an extraction liquid; Analyze described extraction liquid and deliver to test tubes by exit end, molecule in described extraction liquid is combined with described joint portion, heating and blow dried after, a Raman spectrum signal is read by light focus control group, and being input to electronic installation to analyze, described electronic installation comparison Raman spectrum signal and weight information analyze chemical substance contained in thing to be detected.
Preferably, 2nd embodiment of the method for the detection device of the chemical substance quantitative and qualitative analysis of the intelligent type automatic of the present invention also comprises following technology feature in analytical procedure, described electronic installation is by the Raman spectrum signal of described thing to be detected, weight information and the multiple sample Raman spectrum signals being stored in described electronic installation, multiple example weight information is compared, baseline correction, subtracting each other of fluorescence spectrum, data quantitative and qualitative analysis is analyzed, the data of application minimal square error method (LeastSquareMethod) and complete restricted condition minimal square error method (FullConstrainedLeastSquareMethod) analyze the chemical substance contained by described thing to be detected.
Preferably, 2nd embodiment of the method for the detection device of the chemical substance quantitative and qualitative analysis of the intelligent type automatic of the present invention, described smooth focus control group radiates the first light and the 2nd light, the wavelength of described first light and described 2nd light is close, with described in this Scanning Detction during thing to be detected, produce the first spectrogram and the 2nd spectrogram, by subtracting each other the quantitative and qualitative analysis result obtaining detecting dark sample with baseline correction with this fluorescence spectrum, or described smooth focus control group radiates a far red light, during thing to be detected with this Scanning Detction, produce not contain the Raman spectrogram of the noise of fluorescence thus reach the quantitative and qualitative analysis result that can detect dark sample.
Preferably, the method for the detection device of the chemical substance quantitative and qualitative analysis of the intelligent type automatic of the present invention, in Sample location step, described weight measurement unit measures the weight data of determinand in described electronic installation.
Preferably, the method for the detection device of the chemical substance quantitative and qualitative analysis of the intelligent type automatic of the present invention, in solvent treatment step, opens the 2nd valve and makes the solvent in reservoir be sent to heating chamber heating (10 DEG C to 200 DEG C). Preferably, described solvent is organic solvent, water, mixed solvent or carbonic acid gas.
Preferably, the method of the detection device of the chemical substance quantitative and qualitative analysis of the intelligent type automatic of the present invention, in extraction step, opens the first valve and makes the gas in force (forcing) pump be flowed in described detection passage, and push solvent in described testing container, finally in described test tubes. Preferably, the air pressure of the gas that described force (forcing) pump is sent is 0.1kg/cm2��1000kg/cm2��
Preferably, the 3rd embodiment of the detection device of the chemical substance quantitative and qualitative analysis of the intelligent type automatic of the present invention, described detection device comprises a testing container, for storing thing to be detected, one solvent treating unit, for storage, heating and pressurized solvent, one extraction plant, described extraction plant comprises an extracter platform, one perforation group, one switch member, one weight measurement unit and an extraction dropper, described extracter platform is provided with a positioning part, and in described extracter platform, it is provided with a detection passage being connected with described positioning part, described perforation group activity group is located in described detection passage, described switch member and described perforation group are even dynamic to be arranged, described weight measurement unit is corresponding with described positioning part, and group is located at described detection passage, described extraction dropper group is located at the end of described extracter platform and is connected with detection passage, described extraction dropper is provided with a titration end, described solvent is mixed to form extraction liquid via described extraction plant and described thing to be detected, described weight measurement unit exports a weight information, one pipeline, the detection passage of solvent treating unit and described extraction plant described in described pipeline connection, one concentrating unit, described concentrating unit comprises a mobile platform and a detection receptacle, described mobile platform is provided with a heating part, described detection receptacle is seated in described heating part, there is in described detection receptacle a joint portion, described extraction liquid is in described detection receptacle, and through heating and air blowing simmer down to concentrated solution, the molecule in described concentrated solution is combined with described joint portion, one detecting unit, described detecting unit comprises a smooth focus control group, described smooth focus control group comprises a light source device, described light source device one end is provided with one and goes out shaven head, described go out shaven head wear described mobile platform and corresponding with the joint portion of detection receptacle, read a Raman spectrum signal after described smooth focus control group throw light to joint portion,One electronic installation, described electronic installation and described solvent treating unit, described extraction plant, described concentrating unit, described detecting unit electrically link, described electronic installation receives Raman spectrum signal and analyzes chemical substance contained in detection thing, and described electronic installation receives weight information simultaneously.
Preferably, 3rd embodiment of the detection device of the chemical substance quantitative and qualitative analysis of the intelligent type automatic of the present invention also comprises following technology feature, described solvent treating unit comprises the reservoir of a storage of solvent, the heating chamber of one heated solvent, two magnetic valves and a force (forcing) pump being connected with described heating chamber, described pipeline comprise one before pipeline and one after pipeline, reservoir and described heating chamber described in described front pipeline connection, heating chamber described in described rear pipeline connection and described detection passage, described two magnetic valves respectively group be located on described front pipeline and described rear pipeline, adjust described reservoir and described heating chamber and described heating chamber and described detection passage by described two magnetic valves to be conducting state or hinder but state, described force (forcing) pump is as the function pushing described solvent.
Preferably, 3rd embodiment of the detection device of the chemical substance quantitative and qualitative analysis of the intelligent type automatic of the present invention also comprises following technology feature, described perforation group comprises two needle tubing sheets being oppositely arranged, described in each, the shape of needle tubing sheet is corresponding with the structure of described testing container, described in each, the end face of needle tubing sheet has multiple needle tubing, when two needle tubing sheets clip the both sides of described testing container, multiple needle tubings of each needle tubing sheet can be worn in described testing container.
Preferably, 3rd embodiment of the detection device of the chemical substance quantitative and qualitative analysis of the intelligent type automatic of the present invention also comprises following technology feature, the described joint portion of described detection receptacle is surface reinforced Raman active carrier (SERS-activesubstrate), and described surface reinforced Raman active carrier is the sol of metallic particles.
Preferably, 3rd embodiment of the detection device of the chemical substance quantitative and qualitative analysis of the intelligent type automatic of the present invention also comprises following technology feature, described smooth focus control group comprises a light source device and a spectrograph, described light source device can project laser light, UV-light (UV), near infrared light (NearInfrared:NIR), far red light (FarInfrared:FIR) or visible ray, described light source device comprises a body, one luminous source, one goes out shaven head, one group be located at described in go out shaven head focus regulating mechanism, one end that described luminous source group is located in described body, described luminous source projects the light of at least one wavelength, and produce at least one projecting light path and at least one backhaul light path, described bright dipping head group is located at the other end of described body, described go out shaven head corresponding with described detection slide glass, described at least one projecting light path in order through one first collimating lens, a laser rays strainer, spectral filter of the same colour, a beam splitter finally by described go out shaven head to the described joint portion of described detection slide glass, described projecting light path described beam splitter produce one by beam splitter to described detection slide glass one first focus light path, with a 2nd focusing light path reflected by described beam splitter, described 2nd focusing light path is projected through the photosensory assembly that one the 2nd condensing lens is located at described body to a group, the described joint portion detecting slide glass described at least one return light route goes out shaven head, described look spectral filter, a reflector plate, one the 2nd collimating lens and one group of long pass spectral filter being located at described inner body wall described in process in order, and described long pass spectral filter and described spectrograph are electrically connected, described focus regulating mechanism, described photosensory assembly and described spectrograph and described electronic installation are electrically connected, the difference of the path length of the first focusing light path described in described electronic installation comparison and the path length of the 2nd focusing light path, by going out the burnt section of shaven head described in the adjustment of described focus regulating mechanism, goes out the focal length of shaven head with described detection receptacle described in adjusting.
More preferably, 3rd embodiment of the detection device of the chemical substance quantitative and qualitative analysis of the intelligent type automatic of the present invention also comprises following technology feature, described detection device also comprises a light focus control device being electrically connected with described luminous source, described luminous source is provided with at least two luminous crystal grain, the luminous state of the arbitrary luminous crystal grain of described smooth focus control device regulation and control and emission wavelength, make described luminous source project the light of at least one wavelength, and control the wavelength of luminous crystal grain, power, light intensity and shinny state.
More preferably, 3rd embodiment of the detection device of the chemical substance quantitative and qualitative analysis of the intelligent type automatic of the present invention also comprises following technology feature, described electronic installation comprises a data storage element, one reception unit and a processing unit, described data storage element and described reception unit and the mutual transfer of described processing unit, described data storage element stores multiple example weight information, multiple sample Raman spectral information and multiple sample scattering strength values, thus described processing unit is by the weight information of thing to be identified, the relative relation of Raman spectral information and scattering strength numerical value, the data analysis of minimal square error method (LeastSquareMethod) and complete restricted condition minimal square error method (FullConstrainedLeastSquareMethod), multiple example weight information in data storage element described in comparison, multiple sample Raman spectral information and multiple sample scattering strength values carry out baseline correction, subtracting each other of fluorescence spectrum, and data quantitative and qualitative analysis analysis detects the chemical substance contained by thing.
More preferably, 3rd embodiment of the detection method of the chemical substance quantitative and qualitative analysis of the intelligent type automatic of the present invention, described detection method comprises the following steps that equipment is had the testing container of determinand to put in extraction plant by Sample location, described determinand is positioned on weight measurement unit, described weight measurement unit produces a weight information, then operating switch part make perforation group clip and part wear into described testing container; Solvent process by the solvothermal in solvent treating unit and pressurization and is transported to extraction plant; Extract described solvent to be flowed in described testing container with determinand mix and produce an extraction liquid, extract dropper and the described extraction drop of collection is entered in described detection receptacle; Concentrate the extraction liquid in heating and air blowing detection receptacle so that solvent volatilization obtains a concentrated solution; After analyzing the joint portion that light focus control group irradiates described detection receptacle, read Raman spectrum signal, and it is input to electronic installation to analyze, described electronic installation analyses and comparison Raman spectrum signal and weight information, analyzes chemical substance contained in thing to be detected.
More preferably, the 3rd embodiment of the detection method of the chemical substance quantitative and qualitative analysis of the intelligent type automatic of the present invention also comprises following technology feature; In analytical procedure, described electronic installation is by the Raman spectrum signal of thing to be detected, weight information and is stored in multiple sample Raman spectrum signals wherein, multiple example weight information is compared, baseline correction, the subtracting each other of fluorescence spectrum, data quantitative and qualitative analysis are analyzed, the data of application minimal square error method (LeastSquareMethod) and complete restricted condition minimal square error method (FullConstrainedLeastSquareMethod) to be to analyze the chemical substance contained by thing to be detected.
More preferably, 3rd embodiment of the detection method of the chemical substance quantitative and qualitative analysis of the intelligent type automatic of the present invention, described smooth focus control group radiates the first light and the 2nd light, the wavelength of described first light and described 2nd light is very close, by described in Scanning Detction during thing to be detected, produce the first spectrogram and the 2nd spectrogram, qualitative and the quantitative result obtaining detecting dark sample is subtracted each other with baseline correction with this fluorescence spectrum, or described smooth focus control group radiates a far red light, with described in this Scanning Detction during thing to be detected, the Raman spectrogram thus reach producing noise containing fluorescence can detect dark sample qualitative and and quantitative result.
More preferably, 3rd embodiment of the detection method of the chemical substance quantitative and qualitative analysis of the intelligent type automatic of the present invention, in solvent treatment step, described detection method pushes with described force (forcing) pump and has heated described solvent from described solvent treating unit to described extraction plant, and described force (forcing) pump produces 0.1kg/cm2��1000kg/cm2The pressure of scope.Preferably, described solvent is organic solvent, water solvent, mixed solvent or carbonic acid gas.
Therefore, the detection device of the chemical substance quantitative and qualitative analysis of intelligent type automatic provided by the invention, reach the effect of quantitative and qualitative analysis thing to be detected, provide operate fast and easily, full-automaticization and highly sensitive detection function, allow the chemical substance that user can detect described thing to be detected fast and comprises, and reach product pipe and the qualitative and quantitative effect of detection.
Accompanying drawing explanation
Fig. 1 is the schematic diagram of the device of the first embodiment of the detection device of the present invention;
Cardon is made in the operating process that Fig. 2-5 is the first embodiment of the detection device of the present invention;
Fig. 6 is the solvent treating unit of the first embodiment and the enlarged diagram of extraction plant of the detection device of the present invention;
Fig. 7 is the enlarged diagram of the concentrating unit of the first embodiment;
Fig. 8 is the enlarged diagram of detecting unit;
Fig. 9-10 be the 2nd embodiment of the detection device of the present invention make cardon; Figure 11 is the setting drawing of the 3rd embodiment of the detection device of the present invention;
Figure 12 is the concentrating unit of the 3rd embodiment and the enlarged diagram of detecting unit of the detection device of the present invention;
Figure 13 is the schematic diagram of light source device;
Figure 14 is electronic installation figure;
Figure 15 is the profile of detection slide glass,
Figure 16 is the detection method first of the present invention and the flow chart of steps of the 3rd embodiment;
Figure 17 is the spectrogram of the present invention's 785nm laser wavelength detecting trimeric cyanamide;
Figure 18 is the spectrogram of the sensitivity detecting the present invention with the trimeric cyanamide of different concns;
Figure 19 goes to correct the spectrogram reaching best focusing distance in the intensity of the Raman spectral peaks of 520nm in 675.9nm Raman spectral peaks and silicon by comparing trimeric cyanamide;
Figure 20 is the flow chart of steps of the 2nd embodiment of the detection method of the present invention.
Description of reference numerals is as follows:
Testing container 1, solvent treating unit 2, reservoir 21, hot cell 22, magnetic valve 23, magnetic valve 24, force (forcing) pump 25, extraction plant 3, positioning part 31, detection passage 32, perforation group 33, needle tubing sheet 331, needle tubing 3311, switch member 34, weight measurement unit 35, extraction dropper 36, titration end 361, exit end 37, extracter platform 38, pipeline 4, front pipeline 41, rear pipeline 42, first pipeline 43, first valve 431, 2nd pipeline 44, 2nd valve 441, concentrating unit 5, mobile platform 51, displacement motor 511, collection container 52, heating part 53, detecting unit 6, sampling unit 61, mobile motor 611, sampler 612, light focus control group 62, light source device 621, luminous source 6211, luminous crystal grain 62111, go out shaven head 6213, focus regulating mechanism 6214, penetrate light path 6215, backhaul light path 6216, first collimating lens 6217, laser rays strainer 6218, look spectral filter 6219, beam splitter 6220, first focusing light path 6221, 2nd focusing light path 6222, photosensory assembly 6224, reflector plate 6225, 2nd collimating lens 6226, long pass spectral filter 6227, spectrograph 622, light focus control device 623, detection slide glass 63, joint portion 631, concentrated restriction ring 632, Raman spectrum optically focused focus sheet 633, electronic installation 7, data storage element 71, receive unit 72, processing unit 73, test tubes 8, joint portion 81, detection receptacle 9 and joint portion 91.
Embodiment
In order to enable auditor understand the structure of the present invention, feature and other objects further, preferred embodiment appended by now combining is accompanied by accompanying drawing and is described in detail as follows, use the embodiment illustrated by this accompanying drawing only for illustration of the technical scheme of the present invention, and non-limiting the present invention.
Shown in Fig. 1 to Fig. 5, being first embodiment of detection device of chemical substance quantitative and qualitative analysis of a kind of intelligent type automatic of the present invention, comprise a testing container 1, testing container 1 is for storing thing to be detected;One solvent treating unit 2, for storage, heating and pressurized solvent (the present embodiment using the packaging such as stainless steel, glass, capsule-type as testing container 1, thing to be detected can be through the food of process such as smashing, grind and medicine etc.).
One extraction plant 3, comprise an extracter platform 38, one perforation group 33, one switch member 34, one weight measurement unit 35 and an extraction dropper 36, extracter platform 38 is provided with a positioning part 31, a detection passage 32 being connected with positioning part 31 it is provided with in extracter platform 38, perforation group 33 activity group is located in detection passage 32, perforation group 33 clips and pierces through testing container 1, switch member 34 is hubbed on extracter platform 38, and arrange with perforation group 33 is even dynamic, weight measurement unit 35 is corresponding with positioning part 31, and group is located at detection passage 32, extraction dropper 36 groups of ends being located at extracter platform 38, and it is connected with detection passage 32, extraction dropper 36 is provided with a titration end 361, solvent is mixed to form extraction liquid via extracter platform 38 and thing to be detected, weight measurement unit 35 output weight information, one pipeline 4, pipeline 4 is connected the detection passage 32 of solvent treating unit 2 and extraction plant 3.
One concentrating unit 5, comprise mobile platform 51 and a collection container 52, mobile platform 51 is provided with a heating part 53, collection container 52 is placed on heating part 53, extraction liquid is by heating and extract the volatilization of the mode accelerated solvent that dropper 36 is blown, thus promote the concentration of extraction liquid, make extraction liquid become concentrated solution.
One detecting unit 6, comprise sampling unit 61, smooth focus control group 62 and a detection slide glass 63, detection slide glass 63 groups is located on mobile platform 51, the end face of detection slide glass 63 is provided with a joint portion 631, the molecule of joint portion 631 in concentrated solution is combined, and reads a Raman spectrum signal after light focus control group 62 throw light.
One electronic installation 7, the electronic installation 7 of the present invention can be computer equipment or other electronic product, electronic installation 7 electrically links solvent treating unit 2, extraction plant 3, concentrating unit 5, detecting unit 6, electronic installation 7 receives chemical substance contained in Raman spectrum signal analysis detection thing, and electronic installation 7 receives weight information simultaneously.
2nd embodiment of the detection device of the chemical substance quantitative and qualitative analysis of the intelligent type automatic of the present invention, refers to Fig. 9 and Figure 10, and this detection device comprises a testing container 1, and testing container 1 is for storing thing to be detected, one solvent treating unit 2, for storage also heated solvent, one extraction plant 3, extraction plant 3 is provided with a positioning part 31, extraction plant 3 is provided with a detection passage 32 being connected with positioning part 31, extraction plant 3 comprises a perforation group 33, one switch member 34, one weight measurement unit 35 and an exit end 37, perforation group 33 activity group is located in detection passage 32, perforation group 33 clips and pierces through testing container 1, switch member 34 is hubbed on extraction plant 3, and arrange with perforation group 33 is even dynamic, weight measurement unit 35 is corresponding with positioning part 31, and group is located at detection passage 32, exit end 37 is connected with detection passage 32, the solvent heated imports in detection passage 32 by pipeline 4, and dissolve the thing to be detected in testing container 1 through perforation group 33 thus produce extraction liquid, weight measurement unit 35 output weight information, one pipeline 4, pipeline 4 is connected the detection passage 32 of solvent treating unit 2 and extraction plant 3,One test tubes 8, test tubes 8 groups is located at exit end 37 and is connected with detection passage 32, and a joint portion 81 is put in test tubes 8 inner ring winding, and this extraction liquid is passed in test tubes 8 and is combined with joint portion 81; One detecting unit 6, comprises a smooth focus control group 62, and light focus control group 62 throw light is rear to joint portion 81 reads a Raman spectrum signal; One electronic installation 7, electrically linking with solvent treating unit 2, extraction plant 3, detecting unit 6, electronic installation 7 receives Raman spectrum signal, and analyzes Raman spectrum signal, obtaining chemical substance information contained in detection thing, electronic installation 7 receives this weight information.
Thus, concentrated solution is obtained by solvent treating unit 2 and extraction plant 3, and after being combined with the joint portion 81 of test tubes 8 by the molecule of concentrated solution, weight information that Raman spectrum signal and weight measurement unit 35 provide is read to electronic installation 7 via light focus control group 62, electronic installation 7 is by after the weight information of this thing to be detected of analysing and comparing and Raman spectrum signal, again the chemical substance of thing to be detected is combined, reach the effect of quantitative and qualitative analysis thing to be detected, offer fast and operates easily, full-automaticization and highly sensitive detection function, allow the chemical substance that user can detect thing to be detected fast and comprises, and (the difference point of the second embodiment of the present invention and the first embodiment is to reach the effect of product pipe and detection, the present invention only need to by being installed in the test tubes 8 of the end of extraction plant 3, molecule in extraction liquid is combined with test tubes 8, can be in addition qualitative, the molecule of quantified extract liquid and analyze the chemical composition of extraction liquid, and do not need concentrating unit 5, owing to other device is identical with the first embodiment with structure, no longer repeat to illustrate).
3rd embodiment of the detection device of the chemical substance quantitative and qualitative analysis of the intelligent type automatic of the present invention, refers to Figure 11 and Figure 12, and this detection device comprises, a testing container 1, and testing container 1 is for storing thing to be detected, one solvent treating unit 2, for storage, heating and pressurized solvent, one extraction plant 3, comprise an extracter platform 38, one perforation group 33, one switch member 34, one weight measurement unit 35 and an extraction dropper 36, extracter platform 38 is provided with a positioning part 31, a detection passage 32 being connected with positioning part 31 it is provided with in extracter platform 38, perforation group 33 activity group is located in detection passage 32, perforation group 33 clips and pierces through testing container 1, switch member 34 is hubbed on extraction plant 3, and arrange with perforation group 33 is even dynamic, weight measurement unit 35 is corresponding with positioning part 31, and group is located at detection passage 32, extraction dropper 36 groups of ends being located at extracter platform 38, and it is connected with detection passage 32, extraction dropper 36 is provided with a titration end 361, solvent is mixed to form extraction liquid via extraction plant 3 and thing to be detected, weight measurement unit 35 exports a weight information, one pipeline 4, pipeline 4 is connected the detection passage 32 of solvent treating unit 2 and extraction plant 3, one concentrating unit 5, comprise mobile platform 51 and a detection receptacle 9, mobile platform 51 is provided with a heating part 53, detection receptacle 9 is seated in heating part 53, there is in detection receptacle 9 joint portion 91, extraction liquid, in detection receptacle 9, concentrates through heating and air blowing and becomes concentrated solution, and the molecule in this concentrated solution is combined with joint portion 91, one detecting unit 6, comprise a smooth focus control group 62, light focus control group 62 comprises a light source device 621 (the light source device 621 of the present embodiment is laser head), one end of light source device 621 is provided with one and goes out shaven head 6213, going out shaven head 6213 and wear mobile platform 51 and corresponding with the joint portion 91 of detection receptacle 9, light source device 621 throw light reads a Raman spectrum signal after going out shaven head 6213 to joint portion 91,One electronic installation 7, electrically links with solvent treating unit 2, extraction plant 3, concentrating unit 5, detecting unit 6, and electronic installation 7 receives chemical substance contained in Raman spectrum signal analysis detection thing, and electronic installation 7 receives this weight information simultaneously.
Thus, extraction liquid is obtained by solvent treating unit 2 and extraction plant 3, and be combined with the joint portion 91 of detection receptacle 9 by the molecule of this extraction liquid, and by heat and air blowing process by extraction liquid simmer down to concentrated solution, read Raman spectrum signal by light focus control group 62 again and weight information that weight measurement unit 35 provides to electronic installation 7, electronic installation 7 is analysed and compared after the weight information of this thing to be detected and Raman spectrum signal, again the chemical substance of this thing to be detected is combined, to reach the effect of quantitative and qualitative analysis thing to be detected, offer fast and operates easily, full-automaticization and highly sensitive detection function, allow the chemical substance that user can detect thing to be detected fast and comprises, and reach the effect of product pipe and detection, above-mentioned is the embodiment explanation of low-concentration liquid sample.
The third embodiment of the present invention, when detecting high concentration liquid or powdery solid sample, the solid-state determinand of high concentration liquid or powdery being equipped with two milliliters is put in detection receptacle 9 by the 3rd embodiment, light source device 621 automatic focusing is positioned at the joint portion 91 of detection receptacle 9 and reads Raman spectrum (RamanSpectrum), and inputs and draw diffuse spectrum (RamanSpectrum) to electronic installation 7.
In addition, the first embodiment of the detection device of the chemical substance quantitative and qualitative analysis of the intelligent type automatic of the present invention, the 2nd embodiment and the 3rd embodiment comprise following technology feature.
(1) refer to shown in Fig. 2, solvent treating unit 2 comprises the reservoir 21 of a storage of solvent, the heating chamber 22 of one heated solvent, two magnetic valves 23, 24 force (forcing) pump 25(the present invention being connected with heating chamber 22 with first and the 3rd the force (forcing) pump 25 of embodiment be pump, the force (forcing) pump 25 of the 2nd embodiment is air-pot), pipeline 4 comprise one before pipeline 42 after pipeline 41 and, front pipeline 41 is connected reservoir 21 and heating chamber 22, rear pipeline 42 is connected heating chamber 22 and detection passage 32, two magnetic valves 23 respectively group be located on front pipeline 41 and rear pipeline 42, adjust reservoir 21 by two magnetic valves 23 and for conducting state or hinder but state with detection passage 32 with heating chamber 22 and heating chamber 22, force (forcing) pump 25 produces boosting power to push solvent by pipeline 4 in detection passage 32 after starting, after finally mixing with the detection material in testing container 1, push extraction liquid through extraction dropper 36 to outer function, in addition when the magnetic valve 23 being arranged on front pipeline 41 is closing condition, start force (forcing) pump 25 can promote the gas in heating chamber 22 through after pipeline 42, detection passage 32 is to outside extraction dropper 36, thus reach the effect of air blowing. pipeline 4 in the second embodiment of the present invention comprises one first pipeline 43 and one the 2nd pipeline 44, first pipeline 43 is connected force (forcing) pump 25 and detection passage 32,2nd pipeline 44 is connected reservoir 21 and detection passage 32, and it is provided with on one first valve the 431, two pipeline 44 on the first pipeline 43 and it is provided with one the 2nd valve 441.
(2) refer to shown in Fig. 2 and Fig. 7, the detailed structure of perforation group 33 is described further, perforation group 33 comprises two needle tubing sheets 331 being oppositely arranged, when testing container 1 puts into detection passage 32 from positioning part 31, two needle tubing sheets 331 lay respectively at front end face and the aft end face of testing container 1, the shape of each needle tubing sheet 331 is corresponding with the structure of testing container 1, the end face of each needle tubing sheet 331 has multiple needle tubing 3311, when two needle tubing sheets 331 clip the both sides of testing container 1, multiple needle tubings 3311 of each needle tubing sheet 331 can be worn in testing container 1, the inside of testing container 1 is interconnected with detection passage 32.
(3) Fig. 1 is referred to, shown in Fig. 9 and Figure 11, light focus control group 62 comprises a light source device 621 and a spectrograph 622(the present embodiment is Raman spectrometer), light source device 621 can project laser light, UV-light (UV), near infrared light (NearInfrared:NIR), far red light (FarInfrared:FIR) or visible ray, the present embodiment is laser light, light source device 621 comprises a luminous source 6211, one goes out shaven head 6213, one group is located at out the focus regulating mechanism 6214 of shaven head 6213, luminous source 6211 groups of one end being located in light source device 621, luminous source 6211 projects light (such as 785nm or 638nm of at least one wavelength, or 532nm), and produce at least one projecting light path 6215 and at least one backhaul light path 6216, go out bare headed 6213 groups of the other ends being located at light source device 621, go out shaven head 6213 corresponding with detection slide glass 63, at least one projecting light path 6215 is in order through one first collimating lens 6217, one laser rays strainer 6218, spectral filter 6219(of the same colour is 45 degree of inclinations), one beam splitter 6220(T95/R5 beam splitter 6220, in negative 45 degree inclination) go out shaven head 6213 be provided with focusing lens finally by going out shaven head 6213() arrive the joint portion 631 detecting slide glass 63, projecting light path 6215 is at beam splitter 6220(T95/R5 beam splitter 6220) produce one by beam splitter 6220 to the one first focusing light path 6221 detecting slide glass 63, with a 2nd focusing light path 6222 reflected by beam splitter 6220, 2nd focusing light path 6222 is projected through one the 2nd condensing lens 6223 to group and is located at the photosensory assembly 6224 (photosensory assembly 6224 is photoelectric diode) of light source device 621 (light of this at least one wavelength is after beam splitter 6220, the light ray energy of 95% enters into the first focusing light path 6221, the light ray energy of this at least one wavelength of 5% enters into the 2nd focusing light path 6222), angle between first focusing light path 6221 and the 2nd focusing light path 6222 is right angle, and focus the difference of path length of the path length of light path 6221 and the 2nd focusing light path 6222 by focus regulating mechanism 6214(voice coil loudspeaker voice coil electric motor through electronic installation 7 comparison first) adjusting focal length, focal range is 5 millimeters to 8 millimeters, focus regulating mechanism 6214, photosensory assembly 6224 and spectrograph 622 are electrically connected with electronic installation 7.
At least one backhaul light path 6216 passes through shaven head 6213 in order from the joint portion 631 of detection slide glass 63, look spectral filter 6219, one reflector plate 6225, the long pass spectral filter 6227 of one the 2nd collimating lens 6226 and one group of inwall being located at light source device 621, long pass spectral filter 6227 and spectrograph 622 are electrically connected that (long pass spectral filter 6227 and spectrograph 622 are electrically connected by fibre system, this knows technology, so the details being no longer illustrated it makes flowing mode), thus light focus control group 62 can read Raman spectrum (RamanSpectrum), and it is input to electronic installation 7 and carries out quantitative and qualitative analysis analysis.
(4) please refer to shown in Fig. 1 and Figure 17, in order to control the wavelength that luminous source 6211 projects, power, light intensity and shinny state, such as select the far infrared rays luminous source 6211 of not fluorescence excitation radiation to reduce the generation of background fluorescence noise, also comprise a light focus control device 623 being electrically connected with luminous source 6211, luminous source 6211 is provided with at least two luminous crystal grain 62111, light focus control device 623 regulates and controls luminous state and the emission wavelength of arbitrary luminous crystal grain 62111, the present embodiment is by two luminous crystal grain 62111, project light (such as 784nm and 785nm of two kinds of different wave lengths respectively, or 637nm and 638nm, or 531nm and 532nm), and comparison two light reduces reasons for its use fluorescent noise.
(5) refer to shown in Figure 16, electronic installation 7 comprises a data storage element 71, one reception unit 72 and a processing unit 73, data storage element 71 and reception unit 72 and processing unit 73 transfer mutually, data storage element 71 stores multiple example weight information, multiple sample Raman spectral information and multiple sample scattering strength values, thus processing unit 73 is by the weight information of thing to be identified, the relative relation of Raman spectral information and scattering strength numerical value, the data analysis of minimal square error method (LeastSquareMethod) and complete restricted condition minimal square error method (FullConstrainedLeastSquareMethod), the plurality of example weight information in comparison data storage element 71, this multiple multiple sample Raman spectral information and the plurality of sample scattering strength values carry out baseline correction, subtracting each other of fluorescence spectrum, and data quantitative and qualitative analysis analysis detects the chemical substance contained by thing.
(6) referring to shown in Fig. 7, mobile platform 51 comprises multiple displacement motor 511, and multiple displacement motor 511 provides mobile platform more than 51 to displacement and rotation.
(7) refer to shown in Fig. 1, this sampling unit 61 comprises multiple mobile motor 611 and a sampler 612, multiple mobile motor 611 provides sampler more than 612 to displacement and rotation, sampler 612 is quantitative pin (Syringe), quantitative liquid suction pipe (Pipette) or electronic automatic ration imbibition device (MotorizedAuto-Pipette), the mobile motor 611 controlling the displacement motor of complex digital on mobile platform 51 511 by electronic installation 7 and be positioned on sampler 612, reaches the effect of full-automaticization.
In addition, the first embodiment of the present invention, refer to shown in Figure 15, it be detection chip that detection slide glass 63(detects slide glass 63) joint portion 631, the joint portion 81 of test tubes 8 of the 2nd embodiment and the joint portion 91 of the detection receptacle 9 of the 3rd embodiment be concentrated carrier or the surface reinforced Raman active carrier (SERS-activesubstrate) of chemical, physics or biophase affinity, surface reinforced Raman active carrier is the sol of metallic particles, such as silver, gold, copper, nickel ... Deng. metallic surface has the uneven surface of be situated between sight or microcosmic, by the chemical molecular in concentrated solution, the functional group of metallic surface can be adsorbed by active carrier, surface enhanced Raman scattering spectrum (SERS) is utilized to carry out the Molecular Identification of trace and the spectroscopic identification on Nai meter surface like this, even if like this by a small amount of molecular weight, it is possible to reach the qualification of highly sensitive. wherein the surface, joint portion 631 of the first embodiment is provided with a Raman spectrum optically focused focus sheet 633, Raman spectrum optically focused focus sheet 633 for silicon chip or other draw graceful unit spectrum standard specimen, supply the application that optically focused focus sets, and concentrated restriction ring 632 (RetainingRing) it is provided with in the periphery of joint portion 631, the material of concentrated restriction ring 632 is paraffin ring, Te Folong (Teflon) or other chemistry coordinating concentrated solution relative, physics, the chemical material of biological repellency or affinity mutually, it is used for limiting homogeneity and the reliability that concentrated solution is added drop-wise to the scope detecting slide glass 63 and keeps concentrated solution to distribute. luminous source 6211 projects the light scanning Raman spectrum optically focused focus sheet 633 that wavelength is 520nm, reaches maximum intensity and automatically sets light source to the focusing point of detection slide glass 63.
First embodiment of the detection device of the chemical substance quantitative and qualitative analysis of the intelligent type automatic according to aforesaid the present invention and further technology feature, go on to say the detection method of the chemical substance quantitative and qualitative analysis of the intelligent type automatic of the present invention, refer to Figure 12 and coordinate shown in Fig. 1 to Fig. 8 simultaneously, (1) equipment is had the testing container 1 of determinand to put into extraction plant 3 by Sample location, determinand is positioned on weight measurement unit 35, weight measurement unit 35 produces weight information, then operating switch part 34 make perforation group 33 clip and part wear into testing container 1, close positioning part 31 simultaneously,(2) solvent process by solvent (solvent is organic solvent, water solvent, mixed solvent or the carbonic acid gas) heating in solvent treating unit 2 and pressurization and is transported to extraction plant 3, its particular procedures is start the magnetic valve 23 being positioned at front pipeline 41 to allow solvent flow to heating chamber 22 from reservoir 21 to be heated to design temperature, then close magnetic valve 23. (3) mix with determinand in extraction solvent inflow testing container 1 and produce extraction liquid, and extract dropper 36 by collect this extraction drop enter in collection container 52, its particular procedures is the titration end 361 that adjustment mobile platform 51 makes collection container 52 opening alignment extraction dropper 36, start the magnetic valve 24 being positioned at rear pipeline 42, and start force (forcing) pump 25 is sent in detection passage 32 by the solvent heated, and mix with determinand in being flowed into testing container 1 from needle tubing sheet 331 and produce extraction liquid, the extraction drop of collection entered in collection container 52 by extraction dropper 36 (force (forcing) pump 25 produces 0.1kg/cm again2��1000kg/cm2The pressure of scope). (4) concentrated heating and the extraction liquid volatilization accelerated in collection container 52 of blowing obtain a concentrated solution, (5) analyze sampling unit 61 and draw this concentrated solution, and this concentrated solution is added drop-wise to detection slide glass 63 to be combined after blow dried with joint portion 631 again, Raman spectrum signal is read after being irradiated by light focus control group 62, and it is input to electronic installation 7 to analyze, electronic installation 7 is analysed and compared Raman spectrum signal and weight information, analyze chemical substance contained in thing to be detected, its particular procedures is that mobile platform 51 is displaced to the lower section of sampler 612 by displacement motor 511, sampler 612 makes the end of sampler 612 insert in collection container 52 and (such as 0.5 micro-liter) concentrated solution drawn quantitatively by mobile motor 611 by mobile motor 611, rear displacement motor 511 makes detection slide glass 63 be directed at sampler 612, the concentrated solution of absorption is added drop-wise to the joint portion 631 of detection slide glass 63, after sample is carried out fast dry-cure by joint portion 631, mobile platform 51 is displaced to light focus control group 62 times by displacement motor 511, by throw light (laser laser) and spectrograph 622(Raman spectrometer) read Raman spectrum (RamanSpectrum), and be input to electronic installation 7 to read Raman spectrum (Ramanspectrum) compare.
Wherein, the first embodiment of the detection method of the chemical substance quantitative and qualitative analysis of the intelligent type automatic of the present invention comprises following further technology feature.
(1) in analytical procedure, electronic installation 7 is by the Raman spectrum signal of thing to be detected, weight information and the multiple sample Raman spectrum signals being stored in electronic installation 7, plural number example weight information is compared, baseline correction, subtracting each other of fluorescence spectrum, data quantitative and qualitative analysis is analyzed, the data of application minimal square error method (LeastSquareMethod) and complete restricted condition minimal square error method (FullConstrainedLeastSquareMethod) analyze the chemical substance contained by thing to be detected, there is provided full-automaticization with this and operate easily, reach quick detection, qualitative, quantitatively treat the result of the detection thing in side container 1.
(2) in order to reduce noise, light focus control group 62 radiates the first light and the 2nd light, the wavelength of this first light and the 2nd light is very close, during thing to be detected with this Scanning Detction, produce the first spectrogram and the 2nd spectrogram, the quantitative and qualitative analysis result obtaining detecting dark sample is subtracted each other with baseline correction with this fluorescence spectrum, or this light focus control group 62 radiate a far red light, during thing to be detected with this Scanning Detction, generation does not contain the Raman spectrogram of the noise of fluorescence thus reaches the result of the quantitative and qualitative analysis that can detect dark sample, (opticpath of the first light or the 2nd light is all identical with Figure 13 to be such as applied in the result of red wine quantitative and qualitative analysis, so no longer other pictorial representation, and no longer repeat to illustrate).
Referring to shown in Figure 17, Figure 17 is the present invention is that 785nm detects trimeric cyanamide (Melamine) (chemical formula: C by laser wavelength3H6N6), chemical structural formula is as follows
Ordinate of orthogonal axes in Figure 17 is intensity (Intensity (counts/s)), and transverse axis coordinate is wave number (Wavenumber (cm-1)), trimeric cyanamide is at 378.7cm-1��387.6cm-1��581.5cm-1��675.9cm-1��774.7cm-1��986.2cm-1��1445.3cm-1��1560.2cm-1Intensity relatively strong, at 675.9cm-1Crest the highest.
Referring to shown in Figure 18, Figure 18 is that the present invention measures the sensitivity of trimeric cyanamide (Melamine) on detection slide glass 63 (SERS) substrate by laser wavelength 785nm, and gained Raman shift spectrum is at 300cm-1To 1800cm-1Scope, in figure, A to F is respectively the trimeric cyanamide (Melamine) of different concns, and the concentration of A is 10-2molL-1, B concentration be 10-3molL-1, C concentration be 10-4molL-1, D concentration be 10-5molL-1, E concentration be 10-6molL-1, F concentration be 10-7molL-1, G is SERS substrate gold material (goldsubtrate), and as seen from Figure 20, the E of the present invention still can significantly measure 676cm-1Crest, so it is 10 that the sensitivity of the present invention can reach the concentration of trimeric cyanamide (Melamine)-6molL-1��
Referring to shown in Figure 20, Figure 20 is that the present invention is by 10-4M trimeric cyanamide is at detection slide glass 63(SERS substrate) upper by adjustment focus on apart from obtain at 675.9nm (trimeric cyanamide) with at the Raman spectrum of 520nm (Si).. Reach best raman spectrum strength when focusing on distance and be transferred to B to A from C, A is best focusing distance.
The present invention is according to the detection device of the chemical substance quantitative and qualitative analysis of above-mentioned intelligent type automatic, 2nd embodiment of the detection method of the chemical substance quantitative and qualitative analysis of the intelligent type automatic of the present invention is described further, refer to shown in Figure 20, coordinate again shown in Fig. 9 and Figure 10 simultaneously, this detection method comprises the following steps that the testing container 1 that determinand is housed is put into extraction plant 3 by (one) Sample location, and then operating switch part 34 makes perforation group 33 clip testing container 1 and partly wear into testing container 1; (2) solvent process by the solvothermal in solvent treating unit 2 and is pressed and delivered to extraction plant 3; (3) extraction solvent is flowed in testing container 1 to mix with determinand produce extraction liquid; (4) analyze extraction liquid and deliver to test tubes 8 from exit end 37, molecule in this extraction liquid is combined with joint portion 81, heating and blow dried after, a Raman spectrum signal is read by light focus control group 62, and being input to electronic installation 7 to analyze, electronic installation 7 comparison Raman spectrum signal and weight information analyze chemical substance contained in this thing to be detected. (difference of the steps flow chart of the second embodiment of the present invention and the steps flow chart of the first embodiment is, 2nd embodiment does not need enrichment step, but directly derive this extraction liquid in test tubes 8 by extraction plant 3, the detailed process of other flow process is identical with the first embodiment, so no longer repeating to illustrate).
2nd embodiment of the detection method of the chemical substance quantitative and qualitative analysis of the intelligent type automatic of the present invention also comprises following technology feature () in analytical procedure, electronic installation 7 is by the Raman spectrum signal of thing to be detected, weight information and the multiple sample Raman spectrum signals being stored in electronic installation 7, multiple example weight information is compared, baseline correction, subtracting each other of fluorescence spectrum, data quantitative and qualitative analysis is analyzed, the data of application minimal square error method (LeastSquareMethod) and complete restricted condition minimal square error method (FullConstrainedLeastSquareMethod) analyze the chemical substance contained by thing to be detected.(2) light focus control group 62 radiates the first light and the 2nd light, the wavelength of this first light and the 2nd light is close, during with this thing to be detected of this Scanning Detction, produce the first spectrogram and the 2nd spectrogram, the quantitative and qualitative analysis result obtaining detecting dark sample is subtracted each other with baseline correction with this fluorescence spectrum, or light focus control group 62 radiates a far red light, during with this thing to be detected of this Scanning Detction, produce not contain the Raman spectrogram of the noise of fluorescence thus reach the quantitative and qualitative analysis result that can detect dark sample. (3) in Sample location step, weight measurement unit 35 measures the weight data of this determinand in electronic installation 7. (4), in solvent treatment step, open the 2nd valve 441 and make the solvent in reservoir 21 be sent to heating chamber 22 to heat. (5) this solvent is organic solvent, water, mixed solvent or carbonic acid gas. (6) in solvent treatment step, the air pressure of the gas that force (forcing) pump 25 is sent is 0.1kg/cm2��1000kg/cm2. (7) in extraction step, open the first valve 431 and the gas in force (forcing) pump 25 is flowed in detection passage 32, and push solvent to, in testing container 1, being finally combined with joint portion 81 in test tubes 8.
(1) identical with the details process step in the first embodiment to Section 6 in above-mentioned further art feature of 2nd embodiment of the detection method of the chemical substance quantitative and qualitative analysis of the intelligent type automatic of the present invention, so no longer repeating explanation.
The present invention is according to the detection device of the chemical substance quantitative and qualitative analysis of the intelligent type automatic of above-mentioned the present invention, 3rd embodiment of the detection method of the chemical substance quantitative and qualitative analysis of the intelligent type automatic of the present invention is described further, refer to Fig. 6 and simultaneously shown in figure 11 and Figure 12, the step of this detection method comprises Sample location has the testing container 1 of determinand to put into extraction plant 3 equipment, this determinand is positioned on weight measurement unit 35, weight measurement unit 35 produces weight information, then operating switch part 34 make perforation group 33 clip and part wear into testing container 1, solvent process is by the solvothermal in solvent treating unit 2 and pressurization and is transported to the process of extraction plant 3(solvent and is pushed by force (forcing) pump 25 that heated solvent is from solvent treating unit 2 to extraction plant 3, and force (forcing) pump 25 produces 0.1kg/cm2��1000kg/cm2The pressure of scope); Extracting this solvent to be flowed in testing container 1 mix with determinand and produce an extraction liquid, this extraction liquid collected is added drop-wise to detection receptacle 9 interior (being organic solvent, water solvent or mixed solvent in the present embodiment) by extraction dropper 36; Concentrate this extraction liquid in heating and air blowing detection receptacle 9, make solvent volatilization obtain a concentrated solution; After analyzing the joint portion 91 of light focus control group 62 irradiating and detecting container 9, read Raman spectrum signal, and being input to electronic installation 7 to analyze, electronic installation 7 is analysed and compared this Raman spectrum signal and this weight information, analyzes chemical substance contained in thing to be detected.
It is after the joint portion 91 of concentrated solution in detection receptacle 9 is combined that 3rd embodiment of the detection method of the chemical substance quantitative and qualitative analysis of the intelligent type automatic of the present invention also comprises following this detection method of technology feature (), directly obtain Raman spectrum by light focus control group 62 irradiation acquirement, and this Raman spectrum is transferred in electronic installation 7 and compares.(2) in addition, in analytical procedure, the Raman spectrum signal of thing to be detected and weight information are compared by electronic installation 7 with the multiple sample Raman spectrum signal being stored in electronic installation 7 and multiple example weight information, baseline correction, subtracting each other of fluorescence spectrum, data quantitative and qualitative analysis is analyzed, application minimal square error method (LeastSquareMethod) analyzes the chemical substance contained by thing to be detected with the data of complete restricted condition minimal square error method (FullConstrainedLeastSquareMethod), and (effect that this detection method is reached is crossed identical with the first and second embodiments, so no longer repeating to illustrate).
Therefore, the detection device of the chemical substance quantitative and qualitative analysis of intelligent type automatic provided by the invention, reach the effect of quantitative and qualitative analysis thing to be detected, there is provided operate fast and easily, full-automaticization and highly sensitive detection function, allow the chemical substance that user can detect described thing to be detected fast and comprises, and reach product pipe and the qualitative and quantitative effect of detection.
It is to be understood that, the novel content of above-mentioned practicality and embodiment are intended to the practical application proving that the utility model is provided technical scheme, it should not be interpreted as the restriction to the utility model protection domain. Those skilled in the art in spirit of the present utility model and principle, when doing various amendment, equivalent replace or improve. Protection domain of the present utility model is as the criterion with appended claims.

Claims (23)

1. the detection device of the chemical substance quantitative and qualitative analysis of an intelligent type automatic, it is characterised in that, described detection device comprises
One testing container, for storing thing to be detected;
One solvent treating unit, for storage, heating and pressurized solvent;
One extraction plant, described extraction plant comprises an extracter platform, one perforation group, one switch member, one weight measurement unit and an extraction dropper, described extracter platform is provided with a positioning part, and in described extracter platform, it is provided with a detection passage being connected with described positioning part, described perforation group activity group is located in described detection passage, described switch member and described perforation group are even dynamic to be arranged, described weight measurement unit is corresponding with described positioning part, and group is located at described detection passage, described extraction dropper group is located at the end of described extracter platform, and it is connected with described detection passage, described extraction dropper is provided with a titration end, described solvent is mixed to form extraction liquid by described extracter platform and described thing to be detected, described weight measurement unit exports a weight information,
One pipeline, the detection passage of solvent treating unit and described extraction plant described in described pipeline connection;
One concentrating unit, described concentrating unit comprises a mobile platform and a collection container, described mobile platform is provided with a heating part, and described collection container is seated in described heating part, and by heat and extract dropper blow mode by described extraction liquid simmer down to one concentrated solution;
One detecting unit, described detecting unit comprises an adjustment type sampler, a smooth focus control group and a detection slide glass, described detection slide glass group is established on a mobile platform, the end face of described detection slide glass is provided with a joint portion, the molecule of described joint portion in described concentrated solution is combined, and reads a Raman spectrum signal after described smooth focus control group throw light;
One electronic installation, described electronic installation and described solvent treating unit, described extraction plant, described concentrating unit, described detecting unit electrically link, described electronic installation receives Raman spectrum signal and analyzes chemical substance contained in detection thing, and described electronic installation receives described weight information simultaneously;
Thus, after the molecule of concentrated solution is combined with detection slide glass, the weight information provided by described smooth focus control group reading Raman spectrum signal and weight measurement unit is to described electronic installation, after described electronic installation carries out the weight information of thing to be detected and the compare of analysis of Raman spectrum signal, analyze chemical substance contained in thing to be detected.
2. detection device according to claim 1, it is characterized in that, described solvent treating unit comprises the reservoir of a storage of solvent, the heating chamber of one heated solvent, two magnetic valves and a force (forcing) pump being connected with heating chamber, described pipeline comprise one before pipeline and one after pipeline, reservoir and described heating chamber described in described front pipeline connection, heating chamber described in described rear pipeline connection and described detection passage, described two magnetic valves respectively group be located on described front pipeline and described rear pipeline, described reservoir and described heating chamber is adjusted by described two magnetic valves, and described heating chamber and described detection passage are conducting state or hinder but state, described force (forcing) pump pushes described solvent.
3. detection device according to claim 1, it is characterized in that, described perforation group comprises two needle tubing sheets being oppositely arranged, the shape of each described needle tubing sheet is corresponding with the structure of described testing container, the end face of each described needle tubing sheet has multiple needle tubing, when described two needle tubing sheets clip the both sides of described testing container, described multiple needle tubing of described each needle tubing sheet can be worn in described testing container.
4. detection device according to claim 1, it is characterized in that, the described joint portion of described detection slide glass is surface reinforced Raman active carrier, described surface reinforced Raman active carrier is the sol of metallic particles, the surface of described joint portion is provided with a Raman spectrum optically focused focus sheet, and be provided with a concentrated solution restriction ring in the periphery of described joint portion, the material of described concentrated solution restriction ring is paraffin ring or Te Folong.
5. detection device according to claim 4, it is characterized in that, described smooth focus control group comprises a light source device and a spectrograph, described light source device projection laser light, described light source device comprises a body, one luminous source, one goes out shaven head, one group be located at described in go out shaven head focus regulating mechanism, one end that described luminous source group is located in described body, described luminous source projects the light of at least one wavelength, and produce at least one projecting light path and at least one backhaul light path, described bright dipping head group is located at the other end of described body, described go out shaven head corresponding with described detection slide glass,
Described at least one projecting light path in order by one first collimating lens, a laser rays strainer, spectral filter of the same colour, a beam splitter finally by described go out shaven head to the described joint portion of described detection slide glass, described projecting light path described beam splitter produce one by described beam splitter to described detection slide glass one first focus light path, with a 2nd focusing light path reflected by described beam splitter, described 2nd focusing light path is projected through the photosensory assembly that one the 2nd condensing lens is located at described body to a group;
Described at least one backhaul light path goes out shaven head, described look spectral filter, a reflector plate, one the 2nd collimating lens and one group of long pass spectral filter being located at described inner body wall described in being passed through in order by the described joint portion of described detection slide glass, and described long pass spectral filter and described spectrograph are electrically connected;
Described focus regulating mechanism, described photosensory assembly and described spectrograph and described electronic installation are electrically connected;
The difference of the path length of the first focusing light path described in described electronic installation comparison and the path length of described 2nd focusing light path, automatically go out the burnt section of shaven head described in being adjusted by described focus regulating mechanism, described in adjusting, go out the focal length of shaven head with described detection slide glass.
6. detection device according to claim 5, it is characterized in that, described detection device also comprises a light focus control device being electrically connected with described luminous source, described luminous source is provided with at least two luminous crystal grain, the luminous state of the arbitrary described luminous crystal grain of described smooth focus control device regulation and control and emission wavelength, make described luminous source project the light of at least one wavelength, and control the wavelength of described luminous crystal grain, power, light intensity and shinny state.
7. detection device according to claim 1, it is characterized in that, described electronic installation comprises a data storage element, one reception unit and a processing unit, described data storage element and described reception unit and the mutual transfer of described processing unit, described data storage element stores multiple example weight information, multiple sample Raman spectral information and multiple sample scattering strength values, thus described processing unit is by the weight information of thing to be identified, the relative relation of Raman spectral information and scattering strength numerical value, the data analysis of minimal square error method, multiple example weight information in data storage element described in comparison, multiple sample Raman spectral information and multiple sample scattering strength values carry out baseline correction, subtracting each other of fluorescence spectrum, and data quantitative and qualitative analysis analysis detects the chemical substance contained by thing.
8. detection device according to claim 1, it is characterised in that, described mobile platform comprises multiple displacement motor, and described multiple displacement motor provides mobile platform many to displacement and rotation.
9. detection device according to claim 1, it is characterized in that, described adjustment type sampler comprises multiple mobile motor and a sampler, and described multiple mobile motor provides portable sampler many to displacement and rotation, and described sampler is quantitative pin or quantitative liquid suction pipe.
10. the detection device of the chemical substance quantitative and qualitative analysis of an intelligent type automatic, it is characterised in that, described detection device comprises
One testing container, for storing thing to be detected;
One solvent treating unit, for storage also heating and pressurizing solvent;
One extraction plant, described extraction plant comprises an extracter platform, one perforation group, one switch member and a weight measurement unit, described extracter platform is provided with a positioning part, described extracter platform is provided with a detection passage being connected with positioning part and an exit end being connected with described detection passage, described perforation group activity group is located in described detection passage, described perforation group clips and pierces through described testing container, described switch member hub setting is at described extracter platform, and arrange with described perforation group is even dynamic, described weight measurement unit is corresponding with described positioning part, and group is located at detection passage, described exit end is connected with described detection passage, the solvent heated imports in detection passage from pipeline, and dissolve the raw extraction liquid of the produce to be detected in testing container through described perforation group, described weight measurement unit exports a weight information,
One pipeline, the detection passage of solvent treating unit and described extraction plant described in described pipeline connection;
One test tubes, described test tubes group is located at exit end and is connected with described detection passage, is equipped with a joint portion in described test tubes, and extraction liquid leads to and is combined with described joint portion into described test tubes;
One detecting unit, described detecting unit comprises a smooth focus control group, reads a Raman spectrum signal after described smooth focus control group throw light to described joint portion;
One electronic installation, described electronic installation and described solvent treating unit, described extraction plant, described detecting unit electrically link, described electronic installation receives Raman spectrum signal, and analyze Raman spectrum signal, to obtain chemical substance information contained in detection thing, described electronic installation receives weight information;
Thus, concentrated solution is obtained by described solvent treating unit and described extraction plant, and after being combined by the joint portion of the molecule of described concentrated solution with described test tubes, the weight information provided by described smooth focus control group reading Raman spectrum signal and weight measurement unit is to described electronic installation, described electronic installation is by after analytical unit comparison and the weight information analyzing thing to be detected and Raman spectrum signal, analyze chemical substance contained in thing to be detected, to reach the effect of quantitative and qualitative analysis thing to be detected.
11. detection devices according to claim 10, it is characterized in that, described solvent treating unit comprises a force (forcing) pump, a reservoir, a heating chamber being connected with described reservoir with described detection passage, described pipeline comprises one first pipeline and one the 2nd pipeline, force (forcing) pump described in described first pipeline connection and described detection passage, reservoir and described detection passage described in described 2nd pipeline connection, and on described first pipeline, it is provided with one first valve, described 2nd pipeline is provided with one the 2nd valve.
12. detection devices according to claim 10, it is characterized in that, described perforation group comprises two needle tubing sheets being oppositely arranged, described in each, the shape of needle tubing sheet is corresponding with the structure of described testing container, described in each, the end face of needle tubing sheet has multiple needle tubing, when two needle tubing sheets clip the both sides of described testing container, multiple needle tubings of needle tubing sheet described in each can be worn in testing container.
13. detect device according to claim 10, it is characterised in that, the described joint portion of described test tubes is surface reinforced Raman active carrier, and described surface reinforced Raman active carrier is the sol of metallic particles.
14. detection devices according to claim 13, it is characterized in that, described smooth focus control group comprises a light source device and a spectrograph, described light source device can project laser light, described light source device comprises a body, one luminous source, one goes out shaven head, one group be located at described in go out shaven head focus regulating mechanism, one end that described luminous source group is located in described body, described luminous source projects the light of at least one wavelength, and produce at least one projecting light path and at least one backhaul light path, described bright dipping head group is located at the other end of described body, described go out shaven head corresponding with the described joint portion of described test tubes,
Described at least one projecting light path in order through one first collimating lens, a laser rays strainer, spectral filter of the same colour, a beam splitter finally by described go out shaven head to the described joint portion of described test tubes, described at least one projecting light path beam splitter produce one by described beam splitter to described test tubes joint portion one first focus light path, with a 2nd focusing light path reflected by described beam splitter, described 2nd focusing light path is projected through the photosensory assembly that one the 2nd condensing lens is located at described body to a group;
The joint portion of described at least one return light route one test tubes is in order through going out shaven head, look spectral filter, a reflector plate, one the 2nd collimating lens and one group of long pass spectral filter being located at inner body wall, and described long pass spectral filter and described spectrograph are electrically connected;
Described focus regulating mechanism, described photosensory assembly and described spectrograph and described electronic installation are electrically connected;
Described electronic installation comparison first is focused the difference of path length of the path length of light path and the 2nd focusing light path, goes out the burnt section of shaven head, go out the focal length of shaven head with described test tubes described in adjusting described in automatically being adjusted by described focus regulating mechanism.
15. detection devices according to claim 14, it is characterized in that, described detection device also comprises a light focus control device being electrically connected with described luminous source, described luminous source is provided with at least two luminous crystal grain, the luminous state of the arbitrary luminous crystal grain of described smooth focus control device regulation and control and emission wavelength, make described luminous source project the light of at least one wavelength, and control the wavelength of luminous crystal grain, power, light intensity and shinny state.
16. detection devices according to claim 15, it is characterised in that, described smooth focus control group is provided with a rotation motor, and described rotation motor drives described light source device displacement.
The detection device of 17. 1 kinds of intelligent type automatic chemical substance quantitative and qualitative analysis, it is characterised in that, described detection device comprises
One testing container, for storing thing to be detected;
One solvent treating unit, for storage, heating and pressurized solvent;
One extraction plant, described extraction plant comprises an extracter platform, one perforation group, one switch member, one weight measurement unit and an extraction dropper, described extracter platform is provided with a positioning part, and in described extracter platform, it is provided with a detection passage being connected with described positioning part, described perforation group activity group is located in described detection passage, described switch member and described perforation group are even dynamic to be arranged, described weight measurement unit is corresponding with described positioning part, and group is located at described detection passage, described extraction dropper group is located at the end of described extracter platform and is connected with described detection passage, described extraction dropper is provided with a titration end, solvent is mixed to form extraction liquid via described extraction plant and thing to be detected, described weight measurement unit exports a weight information,
The described detection passage of one pipeline, solvent treating unit described in described pipeline connection and described extraction plant;
One concentrating unit, described concentrating unit comprises a mobile platform and a detection receptacle, described mobile platform is provided with a heating part, described detection receptacle is seated in described heating part, there is in described detection receptacle a joint portion, described extraction liquid is in described detection receptacle, and through heating and air blowing simmer down to concentrated solution, the molecule in described concentrated solution is combined with described joint portion;
One detecting unit, described detecting unit comprises a smooth focus control group, described smooth focus control group comprises a light source device, one end of described light source device is provided with one and goes out shaven head, described go out shaven head wear described mobile platform and corresponding with the joint portion of detection receptacle, read a Raman spectrum signal after described smooth focus control group throw light to described joint portion;
One electronic installation, described electronic installation and described solvent treating unit, described extraction plant, described concentrating unit, described detecting unit electrically link, described electronic installation receives Raman spectrum signal and analyzes chemical substance contained in detection thing, and described electronic installation receives weight information simultaneously.
18. detection devices according to claim 17, it is characterized in that, described solvent treating unit comprises the reservoir of a storage of solvent, the heating chamber of one heated solvent, two magnetic valves and a force (forcing) pump being connected with described heating chamber, described pipeline comprise one before pipeline and one after pipeline, reservoir and described heating chamber described in described front pipeline connection, heating chamber described in described rear pipeline connection and described detection passage, described two magnetic valves respectively group be located on described front pipeline and described rear pipeline, adjust described reservoir and described heating chamber and described heating chamber and described detection passage by described two magnetic valves to be conducting state or hinder but state, described force (forcing) pump is as pressurization and the function pushing described solvent.
19. detection devices according to claim 17, it is characterized in that, described perforation group comprises two needle tubing sheets being oppositely arranged, the shape of each needle tubing sheet is corresponding with the structure of described testing container, the end face of each needle tubing sheet has multiple needle tubing, when two needle tubing sheets clip the both sides of described testing container, multiple needle tubings of each needle tubing sheet can be worn in described testing container.
20. detection devices according to claim 17, it is characterised in that, the described joint portion of described detection receptacle is surface reinforced Raman active carrier, and described surface reinforced Raman active carrier is the sol of metallic particles.
21. detection devices according to claim 17, it is characterized in that, described smooth focus control group comprises a light source device and a spectrograph, described light source device projection laser light, described light source device comprises a body, one luminous source, one goes out shaven head, one group be located at described in go out shaven head focus regulating mechanism, one end that described luminous source group is located in body, described luminous source projects the light of at least one wavelength, and produce at least one projecting light path and at least one backhaul light path, described bright dipping head group is located at the other end of described body, described go out shaven head corresponding with a detection receptacle,
Described at least one projecting light path in order through one first collimating lens, a laser rays strainer, spectral filter of the same colour, a beam splitter finally by described go out shaven head to a joint portion of described detection receptacle, described projecting light path described beam splitter produce one by beam splitter to described detection receptacle one first focus light path, with a 2nd focusing light path reflected by described beam splitter, described 2nd focusing light path is projected through the photosensory assembly that one the 2nd condensing lens is located at described body to a group;
The described joint portion of detection receptacle described in described at least one return light route is in order through going out shaven head, look spectral filter, a reflector plate, one the 2nd collimating lens and one group of long pass spectral filter being located at described inner body wall, and described long pass spectral filter and described spectrograph are electrically connected;
Described focus regulating mechanism, described photosensory assembly and described spectrograph and described electronic installation are electrically connected;
Described electronic installation comparison first is focused the difference of path length of the path length of light path and the 2nd focusing light path, goes out the burnt section of shaven head, go out the focal length of shaven head with described detection receptacle described in adjusting described in automatically being adjusted by described focus regulating mechanism.
22. detection devices according to claim 21, it is characterized in that, described detection device also comprises a light focus control device being electrically connected with described luminous source, described luminous source is provided with at least two luminous crystal grain, the luminous state of the arbitrary described luminous crystal grain of described smooth focus control device regulation and control and emission wavelength, make described luminous source project the light of at least one wavelength, and control the wavelength of described luminous crystal grain, power, light intensity and shinny state.
23. detection devices according to claim 17, it is characterized in that, described electronic installation comprises a data storage element, one reception unit and a processing unit, described data storage element and described reception unit and the mutual transfer of described processing unit, described data storage element stores multiple example weight information, multiple sample Raman spectral information and multiple sample scattering strength values, thus described processing unit is by the weight information of thing to be identified, the relative relation of Raman spectral information and scattering strength numerical value, the data of minimal square error method are analyzed, multiple example weight information in data storage element described in comparison, multiple sample Raman spectral information and multiple sample scattering strength values carry out baseline correction, subtracting each other of fluorescence spectrum, and data quantitative and qualitative analysis analyzes the chemical substance contained by described detection thing.
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