CN103623184B - The Chinese medicine for the treatment of prolapse of lumbar intervertebral disc and manufacture method - Google Patents
The Chinese medicine for the treatment of prolapse of lumbar intervertebral disc and manufacture method Download PDFInfo
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Abstract
<b> treats Chinese medicine and the manufacture method of prolapse of lumbar intervertebral disc.It is high that this disease has sickness rate, and treatment time is long, the very easily feature such as recurrence after treatment.Flos Carthami of the present invention is </b><bGreatT.Gre aT.GT40-60</b><b > part, Radix Paeoniae Rubra is </b><bGreatT.Gre aT.GT40-60</b><b > part, Olibanum is </b><bGreatT.Gre aT.GT20-40</b><b > part, eupolyphage sece steleophaga is </b><bGreatT.Gre aT.GT20-40</b><b > part, when being classified as </b><bGreatT.Gre aT.GT20-40</b><b > part, Rhizoma Chuanxiong is </b><bGreatT.Gre aT.GT20-40</b><b > part, Radix Notoginseng is </b><bGreatT.Gre aT.GT40-60</b><b > part, unit acts like a bully </b><bGreatT.Gre aT.GT20-40</b><b > part, Radix Et Rhizoma Rhei is </b><bGreatT.Gre aT.GT20-40</b><b > part, Pheretima is </b><bGreatT.Gre aT.GT20-40</b><b > part, Radix Angelicae Pubescentis is </b><bGreatT.Gre aT.GT20-40</b><b > part, the Cortex Eucommiae is </b><bGreatT.Gre aT.GT20-40</b><b > part, Radix Aconiti Kusnezoffii is </b><bGreatT.Gre aT.GT20-40</b><b > part, Spina Gleditsiae is </b><bGreatT.Gre aT.GT20-40</b><b > part, Radix Achyranthis Bidentatae is </b><bGreatT.Gre aT.GT20-40</b><b > part, Scolopendra is </b><bGreatT.Gre aT.GT1-3</b><bGr eatT.GreaT.GT part, Sanguis Draxonis is </b><bGreatT.Gre aT.GT20-40</b><b > part, Radix Glycyrrhizae is </b><bGreatT.Gre aT.GT20-40</b><b > part, Squama Manis is </b><bGreatT.Gre aT.GT20-40</b><b > part, Os Draconis are </b><bGreatT.Gre aT.GT40-60</b><b > part.The present invention is used for the treatment of prolapse of lumbar intervertebral disc.</b>
Description
Technical field:
The present invention relates to a kind of Chinese medicine and manufacture method for the treatment of prolapse of lumbar intervertebral disc.
Background technology:
According to Ministry of Public Health statistics, China lumbar intervertebral disc protrusion patient has broken through 200,000,000 people, for many years always in rising trend.It is high that this disease has sickness rate, and treatment time is long, the very easily feature such as recurrence after treatment.Have a strong impact on people's quality of life and work, cause serious harm to individual, family, society.The current Therapeutic Method of lumbar intervertebral disc protrusion has: traction, acupuncture, massage, small needle knife, operative treatment, oral Chinese and western drugs, percutaneous dosing etc.But specific aim is poor, easily recurrence, effect are all uncertain, adds the misery of patient." specially good effect " medicine of clinical treatment prolapse of lumbar intervertebral disc disease is deficient.
At present, the medicine of market being treated prolapse of lumbar intervertebral disc disease is more, its therapeutic effect is also affirmative, but treatment cycle, medical expense and user's rule have difference greatly, some medicine uses for a long time and easily develops immunity to drugs, and the easy recurrent exerbation of unstable condition, causes heavy psychological burden to patient, treatment is produced frightened, even desperate psychology.Have many patients in order to short-term response, also adopt the Therapeutic Method of " massage " and " manual reduction ", often cure the symptoms, not the disease, just clinical symptoms is eased, and can not get desirable curative effect, even the state of an illness is more and more serious.Therefore, it is possible to the Chinese medicine finding a kind of effective treatment prolapse of lumbar intervertebral disc disease is one of important topic of Medical circle.
Summary of the invention:
The object of this invention is to provide a kind of easy to use, therapeutic effect good, evident in efficacy, have no side effect, the vacuum infusion method not easily recurred.
Above-mentioned object is realized by following technical scheme:
Treat a Chinese medicine for prolapse of lumbar intervertebral disc, its composition comprises: Flos Carthami, Radix Paeoniae Rubra, Olibanum, eupolyphage sece steleophaga, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Notoginseng, Rhizoma Corydalis, Radix Et Rhizoma Rhei, Pheretima, Radix Angelicae Pubescentis, the Cortex Eucommiae, Radix Aconiti Kusnezoffii, Spina Gleditsiae, Radix Achyranthis Bidentatae, Scolopendra, Sanguis Draxonis, Radix Glycyrrhizae, Squama Manis, Os Draconis, the parts by weight of described Flos Carthami are 40-60 part, the parts by weight of described Radix Paeoniae Rubra are 40-60 part, the parts by weight of described Olibanum are 20-40 part, the parts by weight of described eupolyphage sece steleophaga are 20-40 part, the parts by weight of described Radix Angelicae Sinensis are 20-40 part, the parts by weight of described Rhizoma Chuanxiong are 20-40 part, the parts by weight of described Radix Notoginseng are 40-60 part, the parts by weight of described Rhizoma Corydalis are 20-40 part, the parts by weight of described Radix Et Rhizoma Rhei are 20-40 part, the parts by weight of described Pheretima are 20-40 part, the parts by weight of described Radix Angelicae Pubescentis are 20-40 part, the parts by weight of the described Cortex Eucommiae are 20-40 part, the parts by weight of described Radix Aconiti Kusnezoffii are 20-40 part, the parts by weight of described Spina Gleditsiae are 20-40 part, the parts by weight of described Radix Achyranthis Bidentatae are 20-40 part, the parts by weight of described Scolopendra are 1-3 part, the parts by weight of described Sanguis Draxonis are 20-40 part, the parts by weight of described Radix Glycyrrhizae are 20-40 part, the parts by weight of described Squama Manis are 20-40 part, the parts by weight of described Os Draconis are 40-60 part.
The Chinese medicine of described treatment prolapse of lumbar intervertebral disc, the parts by weight of described Flos Carthami are 45-55 part, the parts by weight of described Radix Paeoniae Rubra are 45-55 part, the parts by weight of described Olibanum are 25-35 part, the parts by weight of described eupolyphage sece steleophaga are 25-35 part, the parts by weight of described Radix Angelicae Sinensis are 25-35 part, the parts by weight of described Rhizoma Chuanxiong are 25-35 part, the parts by weight of described Radix Notoginseng are 45-55 part, the parts by weight of described Rhizoma Corydalis are 25-35 part, the parts by weight of described Radix Et Rhizoma Rhei are 25-35 part, the parts by weight of described Pheretima are 25-35 part, the parts by weight of described Radix Angelicae Pubescentis are 25-35 part, the parts by weight of the described Cortex Eucommiae are 25-35 part, the parts by weight of described Radix Aconiti Kusnezoffii are 25-35 part, the parts by weight of described Spina Gleditsiae are 25-35 part, the parts by weight of described Radix Achyranthis Bidentatae are 25-35 part, the parts by weight of described Scolopendra are 1-3 part, the parts by weight of described Sanguis Draxonis are 25-35 part, the parts by weight of described Radix Glycyrrhizae are 25-35 part, the parts by weight of described Squama Manis are 25-35 part, the parts by weight of described Os Draconis are 45-55 part.
The Chinese medicine of described treatment prolapse of lumbar intervertebral disc, the parts by weight of described Flos Carthami are 40 parts, the parts by weight of described Radix Paeoniae Rubra are 40 parts, the parts by weight of described Olibanum are 20 parts, the parts by weight of described eupolyphage sece steleophaga are 20 parts, the parts by weight of described Radix Angelicae Sinensis are 20 parts, the parts by weight of described Rhizoma Chuanxiong are 20 parts, the parts by weight of described Radix Notoginseng are 40 parts, the parts by weight of described Rhizoma Corydalis are 20 parts, the parts by weight of described Radix Et Rhizoma Rhei are 20 parts, the parts by weight of described Pheretima are 20 parts, the parts by weight of described Radix Angelicae Pubescentis are 20 parts, the parts by weight of the described Cortex Eucommiae are 20 parts, the parts by weight of described Radix Aconiti Kusnezoffii are 20-40 part, the parts by weight of described Spina Gleditsiae are 20-40 part, the parts by weight of described Radix Achyranthis Bidentatae are 20 parts, the parts by weight of described Scolopendra are 1 part, the parts by weight of described Sanguis Draxonis are 20 parts, the parts by weight of described Radix Glycyrrhizae are 20 parts, the parts by weight of described Squama Manis are 20 parts, the parts by weight of described Os Draconis are 40 parts.
The Chinese medicine of described treatment prolapse of lumbar intervertebral disc, the parts by weight of described Flos Carthami are 60 parts, the parts by weight of described Radix Paeoniae Rubra are 60 parts, the parts by weight of described Olibanum are 40 parts, the parts by weight of described eupolyphage sece steleophaga are 40 parts, the parts by weight of described Radix Angelicae Sinensis are 40 parts, the parts by weight of described Rhizoma Chuanxiong are 40 parts, the parts by weight of described Radix Notoginseng are 60 parts, the parts by weight of described Rhizoma Corydalis are 40 parts, the parts by weight of described Radix Et Rhizoma Rhei are 40 parts, the parts by weight of described Pheretima are 40 parts, the parts by weight of described Radix Angelicae Pubescentis are 40 parts, the parts by weight of the described Cortex Eucommiae are 40 parts, the parts by weight of described Radix Aconiti Kusnezoffii are 40 parts, the parts by weight of described Spina Gleditsiae are 40 parts, the parts by weight of described Radix Achyranthis Bidentatae are 40 parts, the parts by weight of described Scolopendra are 3 parts, the parts by weight of described Sanguis Draxonis are 40 parts, the parts by weight of described Radix Glycyrrhizae are 40 parts, the parts by weight of described Squama Manis are 40 parts, the parts by weight of described Os Draconis are 60 parts.
The Chinese medicine of described treatment prolapse of lumbar intervertebral disc, the parts by weight of described Flos Carthami are 50 parts, the parts by weight of described Radix Paeoniae Rubra are 50 parts, the parts by weight of described Olibanum are 30 parts, the parts by weight of described eupolyphage sece steleophaga are 30 parts, the parts by weight of described Radix Angelicae Sinensis are 30 parts, the parts by weight of described Rhizoma Chuanxiong are 30 parts, the parts by weight of described Radix Notoginseng are 50 parts, the parts by weight of described Rhizoma Corydalis are 30 parts, the parts by weight of described Radix Et Rhizoma Rhei are 30 parts, the parts by weight of described Pheretima are 30 parts, the parts by weight of described Radix Angelicae Pubescentis are 30 parts, the parts by weight of the described Cortex Eucommiae are 30 parts, the parts by weight of described Radix Aconiti Kusnezoffii are 30 parts, the parts by weight of described Spina Gleditsiae are 30 parts, the parts by weight of described Radix Achyranthis Bidentatae are 30 parts, the parts by weight of described Scolopendra are 2 parts, the parts by weight of described Sanguis Draxonis are 30 parts, the parts by weight of described Radix Glycyrrhizae are 30 parts, the parts by weight of described Squama Manis are 30 parts, the parts by weight of described Os Draconis are 50 parts.
Treat a preparation method for prolapse of lumbar intervertebral disc Chinese medicine, this preparation method comprises the steps:
Step 1: raw material of Chinese medicine micronizing 300 order taking above-mentioned weight portion obtains medicated powder;
Step 2: ground medicated powder is put into container for stirring even;
Step 3: by first making the semifinished product of pill with an even Medical powder part, be called " mothers and sons ";
Step 4: mothers and sons are placed in the general ball tank of the sugar-coat tank of rotation by " pill ", repeatedly sprays water, spreads pesticides, rotates sugar-coat tank, sticks to completely after on pill, sieves, namely can be made into uniform and smooth water pill until medicated powder;
Step 5: water pill is placed on gravity-flow ventilation place cold drying, temperature controls at 15-25 DEG C, time 3-4 hour;
Step 6: water pill is made pill, every heavy 0.1 gram, often wraps 70 grams.
The preparation method of described treatment prolapse of lumbar intervertebral disc Chinese medicine, described mothers and sons are base particles of pill; With the molding of sugar-coat tank, the process making mothers and sons first uses the cold boiled water of atomizers spray in sugar-coat tank, is then sprinkled into medicated powder, tank is rotated, after fine powder uniform adhesion, with brush by tank with under rotating rightabout brush, now tank is interior to form many tiny medicine groups, add medicated powder again, atomized water spray, rotate sugar-coat tank, repeatable operation like this, until after forming the granule of suitable size, after sieve, choose uniform granule as mothers and sons.
Beneficial effect:
1. the present invention selects traditional Chinese herbal treatment prolapse of lumbar intervertebral disc disease, prolapse of lumbar intervertebral disc is the one of osteoarthritis, is a kind of disease because bone degeneration causes, so while treatment prolapse of lumbar intervertebral disc, first to improve bony structures, supplement the trace element needed for sclerotin.The traditional Chinese medical science think bone and liver,spleen,kidney in close relations, control the first the kidney invigorating of bone.Waist person, house of kidney, incapable of turning round, kidney is by exhausted.Carry " Plain Questions-arteries and veins wants precise and tiny opinion ".Kidney essense foot then skeleton is nourished, and muscles and bones is strong and powerful.But along with the aging of human body, liver spleen renal hypofunction, skeleton lose moisten foster, bone marrow sky is caused to need, muscle arteries and veins loses the degeneration of supporting and then occurring bone, cause articular degeneration, cause lumbar intervertebral disc generation degeneration Anular disruption, Nucleus pulposus, stimulate or oppress tissue around and cause with lumbago.So want cautiously grasping pathogenesis, kidney tonifying marrow facilitating, Psoralen, strong waist knee joint, warming the meridian and promoting blood circulation, removing damp and stopping pain of dispeling cold during treatment.Through the test of pesticide effectiveness with clinically to show: this medicine is evident in efficacy.
The present invention is according to the pathogeny of lumbar vertebra prolapse of lumbar intervertebral disc disease and theory of Chinese medical science, base oneself upon that to consolidate be main, pass through invigorating the liver and kidney, bone and muscle strengthening, promoting blood circulation by removing wind dredging collateral, the pain relieving of warming the meridian dampness removing, is conducive to compactness, the robustness of improving cartilaginous lamina after taking, adjustment vertebral pulp moisture fills level, make the vertebral pulp Hui Na given prominence to, the irritation of contact edema, removes the compressing of nerve root, repairs damage fibrous ring, thus reach and delay regression or alleviate pathological changes definite effect, and short treating period, instant effect, not easily recurs more.
The present invention's righting of getting rid of evils develops simultaneously, and treating both the principal and secondary aspects of a disease, is suitable for the lumbar disc disease that a variety of causes causes, is particularly useful for prolapse of lumbar intervertebral disc, and has no adverse reaction and toxic and side effects.
Invention formulation preparation is simple, taking convenience, evident in efficacy, to cure speed fast.
Anti-inflammation test result of the present invention shows, treatment prolapse of lumbar intervertebral disc Chinese medicine administration group can delay Ovum Gallus domesticus album and cause pedal swelling, and self administration of medication more just has significant difference (P<0.05) with blank group in 1 hour.Prompting: treating the Chinese medicine xylol of prolapse of lumbar intervertebral disc, acetic acid and Ovum Gallus domesticus album all has good antiinflammatory action.
Analgesic test of the present invention result shows, adopts acetic acid writhing test, and treatment prolapse of lumbar intervertebral disc Chinese medicine administration group has the effect of raising pain thresholding, and analgesia percentage rate is 31.3%.
Of the present invention the hemorheological result of the test that affects of rat syndrome of blood stasis model to be shown: treatment prolapse of lumbar intervertebral disc Chinese medicine improves significantly hemorheological property effect.
Detailed description of the invention:
Embodiment 1:
Treat a Chinese medicine for prolapse of lumbar intervertebral disc, its composition comprises: Flos Carthami, Radix Paeoniae Rubra, Olibanum, eupolyphage sece steleophaga, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Notoginseng, Rhizoma Corydalis, Radix Et Rhizoma Rhei, Pheretima, Radix Angelicae Pubescentis, the Cortex Eucommiae, Radix Aconiti Kusnezoffii, Spina Gleditsiae, Radix Achyranthis Bidentatae, Scolopendra, Sanguis Draxonis, Radix Glycyrrhizae, Squama Manis, Os Draconis, the parts by weight of described Flos Carthami are 40-60 part, the parts by weight of described Radix Paeoniae Rubra are 40-60 part, the parts by weight of described Olibanum are 20-40 part, the parts by weight of described eupolyphage sece steleophaga are 20-40 part, the parts by weight of described Radix Angelicae Sinensis are 20-40 part, the parts by weight of described Rhizoma Chuanxiong are 20-40 part, the parts by weight of described Radix Notoginseng are 40-60 part, the parts by weight of described Rhizoma Corydalis are 20-40 part, the parts by weight of described Radix Et Rhizoma Rhei are 20-40 part, the parts by weight of described Pheretima are 20-40 part, the parts by weight of described Radix Angelicae Pubescentis are 20-40 part, the parts by weight of the described Cortex Eucommiae are 20-40 part, the parts by weight of described Radix Aconiti Kusnezoffii are 20-40 part, the parts by weight of described Spina Gleditsiae are 20-40 part, the parts by weight of described Radix Achyranthis Bidentatae are 20-40 part, the parts by weight of described Scolopendra are 1-3 part, the parts by weight of described Sanguis Draxonis are 20-40 part, the parts by weight of described Radix Glycyrrhizae are 20-40 part, the parts by weight of described Squama Manis are 20-40 part, the parts by weight of described Os Draconis are 40-60 part.
Undertaken setting forth the curative effect using this product by clinical observation on the therapeutic effect experiment.
One, physical data
Prolapse of lumbar intervertebral disc patient is respectively chosen 30 routine patients, the prolapse of lumbar intervertebral disc patient chosen is divided into two groups, often organizes 15 people, respectively as matched group and treatment group.
Two, diagnostic criteria
(1) symptom and sign
Patient's conscious waist persistence dull pain or spasm sample severe pain, horizontal position alleviates, and stands, and aggravates, lower limb radiated pain.
(2) imaging examination
CT examination: CT examination image demonstrates the image of the position of intervertebral disk hernia and nerve root, the displacement of dural sac pressurized, demonstrates the situation such as vertebral plate and hypertrophy of ligamentum flavum, Minor articulus hypertrophy, canalis spinalis and lateral recess stenosis simultaneously.
Three, Therapeutic Method:
Matched group: oral ibuprofen capsule: each 0.2 gram, every day 3 times 35 days is a course for the treatment of, one to three course for the treatment of.
Treatment group: oral Chinese medicine: each 5 grams, every day, twice sub-service sooner or later, 35 days was a course for the treatment of, one to three course for the treatment of.
Four, efficacy assessment standard
Cure: pain disappears, the compactness that CT shows cartilaginous lamina improves, and outstanding vertebral pulp Hui Na removes the compressing of nerve root, the annular repair of damage.
Effective: pain obviously alleviates, can orthobiosis and work.
Invalid: pain is not alleviated, after Long-term taking medicine, symptom does not change.
Five, therapeutic effect
Cure: 16 examples, effectively: 14 examples, invalid: 0 example, total effective rate reaches 100%.(referring to following statistical table)
Table 1 is statistical effect table:
Table 1
Treatment group takes medicine of the present invention and matched group takes the contrast of existing similar drug, can be found out by above correction data, it is 27.00% that matched group takes existing similar drug to treatment prolapse of lumbar intervertebral disc cure rate, effective percentage is 60.00%, and treatment group to take medicine of the present invention to treatment prolapse of lumbar intervertebral disc cure rate be 53.33%, effective percentage is 100%.
Within every 6 months, pay a return visit once the healing patient of above-mentioned matched group, treatment group, through the return visit statistics of 3 years, in 8 people that matched group is cured, 4 people's recurrences accounted for 50%, unmanned recurrence in 16 people that treatment group is cured simultaneously.
Therefore a kind of drug products for the treatment of prolapse of lumbar intervertebral disc of the present invention to treatment prolapse of lumbar intervertebral disc cure rate and effective percentage equal existing similar drugs and without recurrence apparently higher than market.From above-mentioned every experimental studies results, a kind of medicine for the treatment of prolapse of lumbar intervertebral disc of the present invention significantly can reach the object for the treatment of prolapse of lumbar intervertebral disc.
Embodiment 2:
The Chinese medicine of the treatment prolapse of lumbar intervertebral disc described in embodiment 1, the parts by weight of described Flos Carthami are 45-55 part, the parts by weight of described Radix Paeoniae Rubra are 45-55 part, the parts by weight of described Olibanum are 25-35 part, the parts by weight of described eupolyphage sece steleophaga are 25-35 part, the parts by weight of described Radix Angelicae Sinensis are 25-35 part, the parts by weight of described Rhizoma Chuanxiong are 25-35 part, the parts by weight of described Radix Notoginseng are 45-55 part, the parts by weight of described Rhizoma Corydalis are 25-35 part, the parts by weight of described Radix Et Rhizoma Rhei are 25-35 part, the parts by weight of described Pheretima are 25-35 part, the parts by weight of described Radix Angelicae Pubescentis are 25-35 part, the parts by weight of the described Cortex Eucommiae are 25-35 part, the parts by weight of described Radix Aconiti Kusnezoffii are 25-35 part, the parts by weight of described Spina Gleditsiae are 25-35 part, the parts by weight of described Radix Achyranthis Bidentatae are 25-35 part, the parts by weight of described Scolopendra are 1-3 part, the parts by weight of described Sanguis Draxonis are 25-35 part, the parts by weight of described Radix Glycyrrhizae are 25-35 part, the parts by weight of described Squama Manis are 25-35 part, the parts by weight of described Os Draconis are 45-55 part.
Embodiment 3:
The Chinese medicine of the treatment prolapse of lumbar intervertebral disc described in embodiment 1, the parts by weight of described Flos Carthami are 40 parts, the parts by weight of described Radix Paeoniae Rubra are 40 parts, the parts by weight of described Olibanum are 20 parts, the parts by weight of described eupolyphage sece steleophaga are 20 parts, the parts by weight of described Radix Angelicae Sinensis are 20 parts, the parts by weight of described Rhizoma Chuanxiong are 20 parts, the parts by weight of described Radix Notoginseng are 40 parts, the parts by weight of described Rhizoma Corydalis are 20 parts, the parts by weight of described Radix Et Rhizoma Rhei are 20 parts, the parts by weight of described Pheretima are 20 parts, the parts by weight of described Radix Angelicae Pubescentis are 20 parts, the parts by weight of the described Cortex Eucommiae are 20 parts, the parts by weight of described Radix Aconiti Kusnezoffii are 20-40 part, the parts by weight of described Spina Gleditsiae are 20-40 part, the parts by weight of described Radix Achyranthis Bidentatae are 20 parts, the parts by weight of described Scolopendra are 1 part, the parts by weight of described Sanguis Draxonis are 20 parts, the parts by weight of described Radix Glycyrrhizae are 20 parts, the parts by weight of described Squama Manis are 20 parts, the parts by weight of described Os Draconis are 40 parts.
Embodiment 4:
The Chinese medicine of the treatment prolapse of lumbar intervertebral disc described in embodiment 1 or 2, the parts by weight of described Flos Carthami are 60 parts, the parts by weight of described Radix Paeoniae Rubra are 60 parts, the parts by weight of described Olibanum are 40 parts, the parts by weight of described eupolyphage sece steleophaga are 40 parts, the parts by weight of described Radix Angelicae Sinensis are 40 parts, the parts by weight of described Rhizoma Chuanxiong are 40 parts, the parts by weight of described Radix Notoginseng are 60 parts, the parts by weight of described Rhizoma Corydalis are 40 parts, the parts by weight of described Radix Et Rhizoma Rhei are 40 parts, the parts by weight of described Pheretima are 40 parts, the parts by weight of described Radix Angelicae Pubescentis are 40 parts, the parts by weight of the described Cortex Eucommiae are 40 parts, the parts by weight of described Radix Aconiti Kusnezoffii are 40 parts, the parts by weight of described Spina Gleditsiae are 40 parts, the parts by weight of described Radix Achyranthis Bidentatae are 40 parts, the parts by weight of described Scolopendra are 3 parts, the parts by weight of described Sanguis Draxonis are 40 parts, the parts by weight of described Radix Glycyrrhizae are 40 parts, the parts by weight of described Squama Manis are 40 parts, the parts by weight of described Os Draconis are 60 parts.
Embodiment 5:
The Chinese medicine of the treatment prolapse of lumbar intervertebral disc described in embodiment 1 or 2, the parts by weight of described Flos Carthami are 50 parts, the parts by weight of described Radix Paeoniae Rubra are 50 parts, the parts by weight of described Olibanum are 30 parts, the parts by weight of described eupolyphage sece steleophaga are 30 parts, the parts by weight of described Radix Angelicae Sinensis are 30 parts, the parts by weight of described Rhizoma Chuanxiong are 30 parts, the parts by weight of described Radix Notoginseng are 50 parts, the parts by weight of described Rhizoma Corydalis are 30 parts, the parts by weight of described Radix Et Rhizoma Rhei are 30 parts, the parts by weight of described Pheretima are 30 parts, the parts by weight of described Radix Angelicae Pubescentis are 30 parts, the parts by weight of the described Cortex Eucommiae are 30 parts, the parts by weight of described Radix Aconiti Kusnezoffii are 30 parts, the parts by weight of described Spina Gleditsiae are 30 parts, the parts by weight of described Radix Achyranthis Bidentatae are 30 parts, the parts by weight of described Scolopendra are 2 parts, the parts by weight of described Sanguis Draxonis are 30 parts, the parts by weight of described Radix Glycyrrhizae are 30 parts, the parts by weight of described Squama Manis are 30 parts, the parts by weight of described Os Draconis are 50 parts.
Embodiment 6:
Treat a preparation method for prolapse of lumbar intervertebral disc Chinese medicine, this preparation method comprises the steps:
Step 1: raw material of Chinese medicine micronizing 300 order taking above-mentioned weight portion obtains medicated powder;
Step 2: ground medicated powder is put into container for stirring even;
Step 3: by first making the semifinished product of pill with an even Medical powder part, be called " mothers and sons ";
Step 4: mothers and sons are placed in the general ball tank of the sugar-coat tank of rotation by " pill ", repeatedly sprays water, spreads pesticides, rotates sugar-coat tank, sticks to completely after on pill, sieves, namely can be made into uniform and smooth water pill until medicated powder;
Step 5: water pill is placed on gravity-flow ventilation place cold drying, temperature controls at 15-25 DEG C, time 3-4 hour;
Step 6: water pill is made pill, every heavy 0.1 gram, often wraps 70 grams.
Embodiment 7:
The preparation method of the treatment prolapse of lumbar intervertebral disc Chinese medicine described in embodiment 6, described mothers and sons are base particles of pill; With the molding of sugar-coat tank, the process making mothers and sons first uses the cold boiled water of atomizers spray in sugar-coat tank, is then sprinkled into medicated powder, tank is rotated, after fine powder uniform adhesion, with brush by tank with under rotating rightabout brush, now tank is interior to form many tiny medicine groups, add medicated powder again, atomized water spray, rotate sugar-coat tank, repeatable operation like this, until after forming the granule of suitable size, after sieve, choose uniform granule as mothers and sons.
The present invention treats the Pharmacodynamic test of active extract of prolapse of lumbar intervertebral disc Chinese medicine
For checking treatment prolapse of lumbar intervertebral disc Herbal pharmacodynamics characteristic, antiinflammatory, analgesia pharmacodynamic experiment are carried out to it, existing that experimental results report is as follows:
Experiment material
Medicine and reagent:
1, prolapse of lumbar intervertebral disc Chinese medicine is treated
2, positive control drug:
Ibuprofen manufacturing enterprise: Sino-America Tianjin Shike Pharmaceutical Co., Ltd.'s authentication code: the accurate word H10900089 of traditional Chinese medicines
Indomethacin manufacturing enterprise: Zhengzhou Huan Ke pharmaceutcal corporation, Ltd authentication code: the accurate word H41020112 of traditional Chinese medicines
Adrenalin hydrochloride injection: manufacturing enterprise: Shanghai Hefeng Pharmaceutical Co., Ltd. produces, the accurate word H31021062 of traditional Chinese medicines, lot number: 100712
Animal: white mice is Kunming kind, rat is SD kind, provides by Heilongjiang University of Chinese Medicine's Experimental Animal Center.The quality certification: 07-3-3.
Method and result
One, on the impact of mice ear
Principle: after causing auricular concha skin turgor with proinflammatory agent, observes and measures the weight that administration group and matched group cause scorching auricular concha, and comparing the difference of their swelling rate.
Operational approach:
1. get Male Kunming strain mice (18 ~ 20g) 50, be divided into 5 groups at random, often organize 10.
2. equal gastric infusion, Chinese drug-treated group drug treatment every day prolapse of lumbar intervertebral disc Chinese medicine 3g/kg, 6g/kg, 12g/kg, blank group gives 0.9% normal saline (NS) 0.3ml/10g every day to indomethacin matched group to indomethacin 8mg/kg every day.For three days on end, after the 3rd day gavage 1 hour, under etherization, before and after the left ear of mice, two sides is coated with 100% dimethylbenzene and is about 0.1ml, and auris dextra does blank.
3. the neck that broken by mice after 1h is put to death, and cuts two ears, laying round auricle respectively, weighing with organizing balance with 9mm diameter card punch at same position along auricle baseline.The left auricle weight of every Mus deducts auris dextra sheet weight and is swelling degree.(left auricle weight-auris dextra sheet weight)/auris dextra sheet weight is as swelling rate.Calculate average and the standard deviation of each swollen tissue, obtain the inhibitory rate of intumesce of administration group by aforementioned formula, and do t test, the significance of difference between comparable group.Result indomethacin group inhibitory rate of intumesce is 45.14%, and Chinese medicine high dose group inhibitory rate of intumesce is 83.62%, and in Chinese medicine, dosage group inhibitory rate of intumesce is 69.37%, and Chinese medicine low dose group inhibitory rate of intumesce is 60.28%.Through statistical procedures, indomethacin group, Chinese drug-treated group compare with blank group, and all there were significant differences (p < 0.05); Indomethacin group compares no significant difference (p > 0.05) with Chinese drug-treated group.
Evaluate: this law is easy and simple to handle, does not need special installation, instant effect, and dosage is few, is applicable to the screening of anti-inflammatory agent.
Lime light:
1. the auricle taken off should match with being coated with the position causing scorching liquid.
2. test medicine is more reasonable with Formulations for systemic administration, and local application influence factor is more, may occur false positive.
The impact of prolapse of lumbar intervertebral disc Chinese medicine on mice ear treated by table 2
Note: compare * P<0.05**P<0.01 with model control group
As can be seen here, treat prolapse of lumbar intervertebral disc Chinese medicine 3g crude drug/kg, 6g crude drug/kg, 12g crude drug/kg xylol induced mice ear swelling and have remarkable inhibitory action.
Above-mentioned the results show, treatment prolapse of lumbar intervertebral disc Chinese medicine administration group and positive drug group have obvious antiinflammatory action, and the 1h effect after proinflammatory agent of administration group is the most obvious.
Two, on the impact of rat paw edema
Get the male rat 50 that body weight is 140 ~ 160g, 5 groups are divided at random by body weight, often organize 10, be respectively dosage group, treatment prolapse of lumbar intervertebral disc Chinese medicine low dose group, indomethacin group in saline group, treatment prolapse of lumbar intervertebral disc Chinese medicine high dose group, treatment prolapse of lumbar intervertebral disc Chinese medicine.Equal gastric infusion, Chinese drug-treated group drug treatment every day prolapse of lumbar intervertebral disc Chinese medicine 3g/kg, 6g/kg, 12g/kg, indomethacin matched group every day, blank group gave 0.9% normal saline (NS) 0.3ml/10g every day to indomethacin 8mg/kg.Mark at the right back ankle joint of each Mus before experiment, measure each Mus right hind foot volume twice with sufficient volume measuring apparatus, average as normal foot volume.30min after administration, every Rat Right metapedes sole of the foot portion clear solution 0.1ml of subcutaneous injection 10% Fresh Egg causes inflammation, respectively at causing scorching rear 0.5h, 1h, 2h, 4h, 6h, measuring and causing scorching sufficient volume, calculates each rat and causes scorching front and back, right back sufficient sole of the foot volume changing value.The results are shown in following table 3.
The impact (X ± s, n=10) of prolapse of lumbar intervertebral disc Chinese medicine test sample on foot swelling caused by Ovum Gallus domesticus album treated by table 3
From experimental result, during 0.5h to 6h upon administration, compared with saline group, the foot swelling rate of each administration group all obviously reduces, wherein remarkable with high dose group diversity.1h after administration, high, medium and low dosage group compares with saline group obvious diversity, and high dose compares with saline group extremely significantly diversity; 2h after administration, high, medium and low dosage group compares with saline group obvious diversity; After administration, 4h with 6h situation is similar, and high, medium and low dosage group compares with saline group obvious diversity
Three, hot-plate analgesic test
Choose the mice 50 of pain territory at 5 ~ 30s, 5 groups are divided at random by basis pain thresholding, often organize 10, equal gastric infusion, Chinese drug-treated group drug treatment every day prolapse of lumbar intervertebral disc Chinese medicine 3g/kg, 6g/kg, 12g/kg, ibuprofen matched group every day, blank group gave 0.9% normal saline (NS) 0.3ml/10g every day to ibuprofen 8mg/kg.After administration 0.5,1,1.5h is measured in the same method each Mus pain thresholding, the results are shown in Table
From table 4, treatment prolapse of lumbar intervertebral disc Chinese medicine 3g crude drug/kg, 6g crude drug/kg, 12g crude drug/kg has obvious inhibitory action to the pain reaction that thermostimulation mice causes.
The impact that prolapse of lumbar intervertebral disc Chinese medicine reacts mice thermostimulation treated by table 4
Four, to the analgesic activity (writhing method) of white mice
Get Kun Ming mice (male) 50, be divided into 5 groups at random, often organize 10, each group of medication, medication, dosage are all the same, for three days on end, after perfusion in the 3rd day 30 minutes, 0.6% acetate solution 0.2ml is all injected in each Mus abdominal cavity, observe to inject in latter 30 minutes and occur that writhing response (stretches hind leg, abdominal part shrinks indent, buttocks is raised) number of mice, calculate analgesia Shuai ﹝ analgesia rate=(experimental group without writhing response number of animals-matched group without writhing response number of animals)/matched group writhing response Dong Wu Shuo ﹞, the results are shown in Table 5.
The impact that prolapse of lumbar intervertebral disc Chinese medicine Dichlorodiphenyl Acetate causes the pain reaction of mice treated by table 5
From table 5, treatment prolapse of lumbar intervertebral disc Chinese medicine 3g crude drug/kg, 6g crude drug/kg, 12g crude drug/kg Dichlorodiphenyl Acetate causes the pain reaction of mice to have obvious inhibitory action.
Five, on the hemorheological impact of rat syndrome of blood stasis model
1, experiment grouping SD rat 48, male and female half and half, body weight 180 ~ 220g, is divided into six groups at random, often organizes eight, if blank group, model group, positive controls, the large, medium and small dosage group for the treatment of prolapse of lumbar intervertebral disc Chinese medicine.
, method Normal group and model group gavage distilled water, FUFANG DANSHEN PIAN group gavage 0.782g/kg, 4th ~ 6 groups of gavage treatment every day prolapse of lumbar intervertebral disc Chinese medicine 12g, 6g, 3g crude drug/kg, once a day, continuous 5 days, 1h after last administration, except blank group, all the other are group equal subcutaneous injection adrenalin hydrochloride 0.15mg/ respectively, after injection 2h, below respectively organize rat and all immerse 5min in 4 DEG C of frozen water, the water on rat fur is dried after taking-up, only subcutaneous injection adrenalin hydrochloride 0.15mg/ is respectively organized again after 2h, water 18h is can't help in fasting, with 10 ﹪ urethane 1mL/100g intraperitoneal injection of anesthesia, be separated common carotid artery, intubate gets blood 5mL, blood is made naturally to flow into the test tube containing a small amount of heparin sodium, stream limit, limit is shaken, make blood anticoagulant, the full-automatic blood rheology test instrument of ZL4500i detects, room temperature 22 DEG C, sample constant temperature 37 DEG C.
, this group of result test data
comparing between ± s expression group takes t to check, and with P < 0.05 for significant difference, P < 0.01 is pole significant difference.Statistical procedures adopts Excel2003.Result of the test sees the following form.
Model group whole blood viscosity value (200mpa.s), whole blood viscosity value (30mpa.s), whole blood viscosity value (5mpa.s), whole blood viscosity value (1mpa.s), plasma viscosity, Fibrinogen and erythrocyte overstock all apparently higher than blank group (P < 0.01 ~ P < 0.05), and blood stasis model success is described, FUFANG DANSHEN PIAN group and treatment prolapse of lumbar intervertebral disc Chinese medicine 12g, 6g crude drug/kg group significantly can reduce whole blood viscosity value (200mpa.s, 30mpa.s, 5mpa.s, 1mpa.s) plasma viscosity and Fibrinogen (P < 0.01 ~ P < 0.05), FUFANG DANSHEN PIAN group and treatment prolapse of lumbar intervertebral disc Chinese medicine 12g, crude drug/kg group significantly can reduce packed cell volume (P < 0.01), treatment prolapse of lumbar intervertebral disc Chinese medicine 3g crude drug/kg also obviously can reduce whole blood viscosity value (200mpa.s, 30mpa.s, 5mpa.s, 1mpa.s) plasma viscosity and Fibrinogen (P < 0.01 ~ P < 0.05), result shows this product and to improve significantly hemorheological property effect.
Table 6 treats prolapse of lumbar intervertebral disc Chinese medicine to the hemorheological impact of rat syndrome of blood stasis model
Note: compare with blank group: △ P < 0.01; Compare with model control group: ▲ P < 0.05, ◇ P < 0.01.
Table 7 treat prolapse of lumbar intervertebral disc Chinese medicine on the hemorheological impact of rat syndrome of blood stasis model (
± s)
Note: compare with blank group: △ P < 0.01; Compare with model control group: ▲ P < 0.05, ◇ P < 0.01.
Table 8 treat prolapse of lumbar intervertebral disc Chinese medicine on the hemorheological impact of rat syndrome of blood stasis model (
± s)
Note: compare with blank group: △ P < 0.01; Compare with model control group: ▲ P < 0.05, ◇ P < 0.01.
Anti-inflammation test result shows, treatment prolapse of lumbar intervertebral disc Chinese medicine administration group can delay Ovum Gallus domesticus album and cause pedal swelling, and self administration of medication more just has significant difference (P<0.05) with blank group in 1 hour.Prompting: treating the Chinese medicine xylol of prolapse of lumbar intervertebral disc, acetic acid and Ovum Gallus domesticus album all has good antiinflammatory action.
Analgesic test result shows, adopts acetic acid writhing test, and treatment prolapse of lumbar intervertebral disc Chinese medicine administration group has the effect of raising pain thresholding, and analgesia percentage rate is 31.3%.
The hemorheological result of the test that affects of rat syndrome of blood stasis model is shown: treatment prolapse of lumbar intervertebral disc Chinese medicine improves significantly hemorheological property effect.
Claims (7)
1. treat a Chinese medicine for prolapse of lumbar intervertebral disc, by Flos Carthami, Radix Paeoniae Rubra, Olibanum, eupolyphage sece steleophaga, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Notoginseng, Rhizoma Corydalis, Radix Et Rhizoma Rhei, Pheretima, Radix Angelicae Pubescentis, the Cortex Eucommiae, Radix Aconiti Kusnezoffii, Spina Gleditsiae, Radix Achyranthis Bidentatae, Scolopendra, Sanguis Draxonis, Radix Glycyrrhizae, Squama Manis, Os Draconis form, it is characterized in that: the parts by weight of described Flos Carthami are 40-60 part, the parts by weight of described Radix Paeoniae Rubra are 40-60 part, the parts by weight of described Olibanum are 20-40 part, the parts by weight of described eupolyphage sece steleophaga are 20-40 part, the parts by weight of described Radix Angelicae Sinensis are 20-40 part, the parts by weight of described Rhizoma Chuanxiong are 20-40 part, the parts by weight of described Radix Notoginseng are 40-60 part, the parts by weight of described Rhizoma Corydalis are 20-40 part, the parts by weight of described Radix Et Rhizoma Rhei are 20-40 part, the parts by weight of described Pheretima are 20-40 part, the parts by weight of described Radix Angelicae Pubescentis are 20-40 part, the parts by weight of the described Cortex Eucommiae are 20-40 part, the parts by weight of described Radix Aconiti Kusnezoffii are 20-40 part, the parts by weight of described Spina Gleditsiae are 20-40 part, the parts by weight of described Radix Achyranthis Bidentatae are 20-40 part, the parts by weight of described Scolopendra are 1-3 part, the parts by weight of described Sanguis Draxonis are 20-40 part, the parts by weight of described Radix Glycyrrhizae are 20-40 part, the parts by weight of described Squama Manis are 20-40 part, the parts by weight of described Os Draconis are 40-60 part.
2. the Chinese medicine for the treatment of prolapse of lumbar intervertebral disc according to claim 1, it is characterized in that: the parts by weight of described Flos Carthami are 45-55 part, the parts by weight of described Radix Paeoniae Rubra are 45-55 part, the parts by weight of described Olibanum are 25-35 part, the parts by weight of described eupolyphage sece steleophaga are 25-35 part, the parts by weight of described Radix Angelicae Sinensis are 25-35 part, the parts by weight of described Rhizoma Chuanxiong are 25-35 part, the parts by weight of described Radix Notoginseng are 45-55 part, the parts by weight of described Rhizoma Corydalis are 25-35 part, the parts by weight of described Radix Et Rhizoma Rhei are 25-35 part, the parts by weight of described Pheretima are 25-35 part, the parts by weight of described Radix Angelicae Pubescentis are 25-35 part, the parts by weight of the described Cortex Eucommiae are 25-35 part, the parts by weight of described Radix Aconiti Kusnezoffii are 25-35 part, the parts by weight of described Spina Gleditsiae are 25-35 part, the parts by weight of described Radix Achyranthis Bidentatae are 25-35 part, the parts by weight of described Scolopendra are 1-3 part, the parts by weight of described Sanguis Draxonis are 25-35 part, the parts by weight of described Radix Glycyrrhizae are 25-35 part, the parts by weight of described Squama Manis are 25-35 part, the parts by weight of described Os Draconis are 45-55 part.
3. the Chinese medicine for the treatment of prolapse of lumbar intervertebral disc according to claim 1, it is characterized in that: the parts by weight of described Flos Carthami are 40 parts, the parts by weight of described Radix Paeoniae Rubra are 40 parts, the parts by weight of described Olibanum are 20 parts, the parts by weight of described eupolyphage sece steleophaga are 20 parts, the parts by weight of described Radix Angelicae Sinensis are 20 parts, the parts by weight of described Rhizoma Chuanxiong are 20 parts, the parts by weight of described Radix Notoginseng are 40 parts, the parts by weight of described Rhizoma Corydalis are 20 parts, the parts by weight of described Radix Et Rhizoma Rhei are 20 parts, the parts by weight of described Pheretima are 20 parts, the parts by weight of described Radix Angelicae Pubescentis are 20 parts, the parts by weight of the described Cortex Eucommiae are 20 parts, the parts by weight of described Radix Aconiti Kusnezoffii are 20-40 part, the parts by weight of described Spina Gleditsiae are 20-40 part, the parts by weight of described Radix Achyranthis Bidentatae are 20 parts, the parts by weight of described Scolopendra are 1 part, the parts by weight of described Sanguis Draxonis are 20 parts, the parts by weight of described Radix Glycyrrhizae are 20 parts, the parts by weight of described Squama Manis are 20 parts, the parts by weight of described Os Draconis are 40 parts.
4. the Chinese medicine for the treatment of prolapse of lumbar intervertebral disc according to claim 1, it is characterized in that: the parts by weight of described Flos Carthami are 60 parts, the parts by weight of described Radix Paeoniae Rubra are 60 parts, the parts by weight of described Olibanum are 40 parts, the parts by weight of described eupolyphage sece steleophaga are 40 parts, the parts by weight of described Radix Angelicae Sinensis are 40 parts, the parts by weight of described Rhizoma Chuanxiong are 40 parts, the parts by weight of described Radix Notoginseng are 60 parts, the parts by weight of described Rhizoma Corydalis are 40 parts, the parts by weight of described Radix Et Rhizoma Rhei are 40 parts, the parts by weight of described Pheretima are 40 parts, the parts by weight of described Radix Angelicae Pubescentis are 40 parts, the parts by weight of the described Cortex Eucommiae are 40 parts, the parts by weight of described Radix Aconiti Kusnezoffii are 40 parts, the parts by weight of described Spina Gleditsiae are 40 parts, the parts by weight of described Radix Achyranthis Bidentatae are 40 parts, the parts by weight of described Scolopendra are 3 parts, the parts by weight of described Sanguis Draxonis are 40 parts, the parts by weight of described Radix Glycyrrhizae are 40 parts, the parts by weight of described Squama Manis are 40 parts, the parts by weight of described Os Draconis are 60 parts.
5. the Chinese medicine for the treatment of prolapse of lumbar intervertebral disc according to claim 1 and 2, it is characterized in that: the parts by weight of described Flos Carthami are 50 parts, the parts by weight of described Radix Paeoniae Rubra are 50 parts, the parts by weight of described Olibanum are 30 parts, the parts by weight of described eupolyphage sece steleophaga are 30 parts, the parts by weight of described Radix Angelicae Sinensis are 30 parts, the parts by weight of described Rhizoma Chuanxiong are 30 parts, the parts by weight of described Radix Notoginseng are 50 parts, the parts by weight of described Rhizoma Corydalis are 30 parts, the parts by weight of described Radix Et Rhizoma Rhei are 30 parts, the parts by weight of described Pheretima are 30 parts, the parts by weight of described Radix Angelicae Pubescentis are 30 parts, the parts by weight of the described Cortex Eucommiae are 30 parts, the parts by weight of described Radix Aconiti Kusnezoffii are 30 parts, the parts by weight of described Spina Gleditsiae are 30 parts, the parts by weight of described Radix Achyranthis Bidentatae are 30 parts, the parts by weight of described Scolopendra are 2 parts, the parts by weight of described Sanguis Draxonis are 30 parts, the parts by weight of described Radix Glycyrrhizae are 30 parts, the parts by weight of described Squama Manis are 30 parts, the parts by weight of described Os Draconis are 50 parts.
6. the preparation method for the treatment of prolapse of lumbar intervertebral disc Chinese medicine according to claim 1, is characterized in that: this preparation method comprises the steps:
Step 1: raw material of Chinese medicine micronizing 300 order taking above-mentioned weight portion obtains medicated powder;
Step 2: ground medicated powder is put into container for stirring even;
Step 3: by first making the semifinished product of pill with an even Medical powder part, be called " mothers and sons ";
Step 4: mothers and sons are placed in the general ball tank of the sugar-coat tank of rotation by " pill ", repeatedly sprays water, spreads pesticides, rotates sugar-coat tank, sticks to completely after on pill, sieves, namely can be made into uniform and smooth water pill until medicated powder;
Step 5: water pill is placed on gravity-flow ventilation place cold drying, temperature controls at 15-25 DEG C, time 3-4 hour;
Step 6: water pill is made pill, every heavy 0.1 gram, often wraps 70 grams.
7. the preparation method for the treatment of prolapse of lumbar intervertebral disc Chinese medicine according to claim 6, is characterized in that: described mothers and sons are base particles of pill; With the molding of sugar-coat tank, the process making mothers and sons first uses the cold boiled water of atomizers spray in sugar-coat tank, is then sprinkled into medicated powder, tank is rotated, after fine powder uniform adhesion, with brush by tank with under rotating rightabout brush, now tank is interior to form many tiny medicine groups, add medicated powder again, atomized water spray, rotate sugar-coat tank, repeatable operation like this, until after forming the granule of suitable size, after sieve, choose uniform granule as mothers and sons.
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