CN103623184A - Traditional Chinese medicine for treating lumbar disc herniation and preparation method of traditional Chinese medicine - Google Patents
Traditional Chinese medicine for treating lumbar disc herniation and preparation method of traditional Chinese medicine Download PDFInfo
- Publication number
- CN103623184A CN103623184A CN201310624721.5A CN201310624721A CN103623184A CN 103623184 A CN103623184 A CN 103623184A CN 201310624721 A CN201310624721 A CN 201310624721A CN 103623184 A CN103623184 A CN 103623184A
- Authority
- CN
- China
- Prior art keywords
- parts
- weight
- radix
- chinese medicine
- described radix
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a traditional Chinese medicine for treating lumbar disc herniation and a preparation method of the traditional Chinese medicine. The lumbar disc herniation has the characteristics of high morbidity, long treatment time, extreme easiness for recurrence after treatment and the like. The traditional Chinese medicine is prepared from 40-60 parts of safflower, 40-60 parts of red paeony roots, 20-40 parts of olibanum, 20-40 parts of ground beetle, 20-40 parts of angelica sinensis, 20-40 parts of rhizoma chuanxiong, 40-60 parts of pseudo-ginseng, 20-40 parts of rhizoma corydalis, 20-40 parts of rheum officinale, 20-40 parts of earthworms, 20-40 parts of radix angelicae pubescentis, 20-40 parts of eucommia ulmoides, 20-40 parts of radix aconiti agrestis, 20-40 parts of spina gleditsiae, 20-40 parts of radix achyranthis bidentatae, 1-3 parts of centipedes, 20-40 parts of dragon blood, 20-40 parts of liquorice, 20-40 parts of pangolin and 40-60 parts of dragon bone. The traditional Chinese medicine is used for treating lumbar disc herniation.
Description
Technical field:
The present invention relates to a kind of Chinese medicine and manufacture method for the treatment of prolapse of lumbar intervertebral disc.
Background technology:
According to Ministry of Public Health statistics, China lumbar intervertebral disc protrusion patient has broken through 200,000,000 people, for many years always in rising trend.It is high that this disease has sickness rate, and treatment time is long, the feature such as recurrence very easily after treatment.Have a strong impact on people's quality of life and work, caused serious harm to individual, family, society.The current Therapeutic Method of lumbar intervertebral disc protrusion has: traction, acupuncture, massage, small needle knife, operative treatment, oral Chinese and western drugs, percutaneous dosing etc.But poor, the easy recurrence of specific aim, effect are all uncertain, increased patient's misery." specially good effect " medicine for the treatment of clinically prolapse of lumbar intervertebral disc disease is deficient.
At present, the medicine for the treatment of prolapse of lumbar intervertebral disc disease on market is more, its therapeutic effect is also sure, but treatment cycle, medical expense and user's rule have greatly difference, the long-time use of some medicine is easily developed immunity to drugs, and unstable condition is outbreak repeatedly easily, to patient, causes heavy psychological burden, treatment is produced to fear, even desperate psychology.Have many patients for short-term response, also adopt the Therapeutic Method of " massage " and " manual reduction ", often cure the symptoms, not the disease, just clinical symptoms is eased, and can not get desirable curative effect, and even the state of an illness is more and more serious.Therefore the Chinese medicine that, can find a kind of effective treatment prolapse of lumbar intervertebral disc disease is one of important topic of Medical circle.
Summary of the invention:
The object of this invention is to provide a kind of easy to use, therapeutic effect good, evident in efficacy, have no side effect, be difficult for the priming by vacuum method of recurrence.
Above-mentioned object realizes by following technical scheme:
Treat a Chinese medicine for prolapse of lumbar intervertebral disc, its composition comprises: Flos Carthami, Radix Paeoniae Rubra, Olibanum, eupolyphage sece steleophaga, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Notoginseng, Rhizoma Corydalis, Radix Et Rhizoma Rhei, Pheretima, Radix Angelicae Pubescentis, the Cortex Eucommiae, Radix Aconiti Kusnezoffii, Spina Gleditsiae, Radix Achyranthis Bidentatae, Scolopendra, Sanguis Draxonis, Radix Glycyrrhizae, Squama Manis, Os Draconis, the parts by weight of described Flos Carthami are 40-60 part, the parts by weight of described Radix Paeoniae Rubra are 40-60 part, the parts by weight of described Olibanum are 20-40 part, the parts by weight of described eupolyphage sece steleophaga are 20-40 part, the parts by weight of described Radix Angelicae Sinensis are 20-40 part, the parts by weight of described Rhizoma Chuanxiong are 20-40 part, the parts by weight of described Radix Notoginseng are 40-60 part, the parts by weight of described Rhizoma Corydalis are 20-40 part, the parts by weight of described Radix Et Rhizoma Rhei are 20-40 part, the parts by weight of described Pheretima are 20-40 part, the parts by weight of described Radix Angelicae Pubescentis are 20-40 part, the parts by weight of the described Cortex Eucommiae are 20-40 part, the parts by weight of described Radix Aconiti Kusnezoffii are 20-40 part, the parts by weight of described Spina Gleditsiae are 20-40 part, the parts by weight of described Radix Achyranthis Bidentatae are 20-40 part, the parts by weight of described Scolopendra are 1-3 part, the parts by weight of described Sanguis Draxonis are 20-40 part, the parts by weight of described Radix Glycyrrhizae are 20-40 part, the parts by weight of described Squama Manis are 20-40 part, the parts by weight of described Os Draconis are 40-60 part.
The Chinese medicine of described treatment prolapse of lumbar intervertebral disc, the parts by weight of described Flos Carthami are 45-55 part, the parts by weight of described Radix Paeoniae Rubra are 45-55 part, the parts by weight of described Olibanum are 25-35 part, the parts by weight of described eupolyphage sece steleophaga are 25-35 part, the parts by weight of described Radix Angelicae Sinensis are 25-35 part, the parts by weight of described Rhizoma Chuanxiong are 25-35 part, the parts by weight of described Radix Notoginseng are 45-55 part, the parts by weight of described Rhizoma Corydalis are 25-35 part, the parts by weight of described Radix Et Rhizoma Rhei are 25-35 part, the parts by weight of described Pheretima are 25-35 part, the parts by weight of described Radix Angelicae Pubescentis are 25-35 part, the parts by weight of the described Cortex Eucommiae are 25-35 part, the parts by weight of described Radix Aconiti Kusnezoffii are 25-35 part, the parts by weight of described Spina Gleditsiae are 25-35 part, the parts by weight of described Radix Achyranthis Bidentatae are 25-35 part, the parts by weight of described Scolopendra are 1-3 part, the parts by weight of described Sanguis Draxonis are 25-35 part, the parts by weight of described Radix Glycyrrhizae are 25-35 part, the parts by weight of described Squama Manis are 25-35 part, the parts by weight of described Os Draconis are 45-55 part.
The Chinese medicine of described treatment prolapse of lumbar intervertebral disc, the parts by weight of described Flos Carthami are 40 parts, the parts by weight of described Radix Paeoniae Rubra are 40 parts, the parts by weight of described Olibanum are 20 parts, the parts by weight of described eupolyphage sece steleophaga are 20 parts, the parts by weight of described Radix Angelicae Sinensis are 20 parts, the parts by weight of described Rhizoma Chuanxiong are 20 parts, the parts by weight of described Radix Notoginseng are 40 parts, the parts by weight of described Rhizoma Corydalis are 20 parts, the parts by weight of described Radix Et Rhizoma Rhei are 20 parts, the parts by weight of described Pheretima are 20 parts, the parts by weight of described Radix Angelicae Pubescentis are 20 parts, the parts by weight of the described Cortex Eucommiae are 20 parts, the parts by weight of described Radix Aconiti Kusnezoffii are 20-40 part, the parts by weight of described Spina Gleditsiae are 20-40 part, the parts by weight of described Radix Achyranthis Bidentatae are 20 parts, the parts by weight of described Scolopendra are 1 part, the parts by weight of described Sanguis Draxonis are 20 parts, the parts by weight of described Radix Glycyrrhizae are 20 parts, the parts by weight of described Squama Manis are 20 parts, the parts by weight of described Os Draconis are 40 parts.
The Chinese medicine of described treatment prolapse of lumbar intervertebral disc, the parts by weight of described Flos Carthami are 60 parts, the parts by weight of described Radix Paeoniae Rubra are 60 parts, the parts by weight of described Olibanum are 40 parts, the parts by weight of described eupolyphage sece steleophaga are 40 parts, the parts by weight of described Radix Angelicae Sinensis are 40 parts, the parts by weight of described Rhizoma Chuanxiong are 40 parts, the parts by weight of described Radix Notoginseng are 60 parts, the parts by weight of described Rhizoma Corydalis are 40 parts, the parts by weight of described Radix Et Rhizoma Rhei are 40 parts, the parts by weight of described Pheretima are 40 parts, the parts by weight of described Radix Angelicae Pubescentis are 40 parts, the parts by weight of the described Cortex Eucommiae are 40 parts, the parts by weight of described Radix Aconiti Kusnezoffii are 40 parts, the parts by weight of described Spina Gleditsiae are 40 parts, the parts by weight of described Radix Achyranthis Bidentatae are 40 parts, the parts by weight of described Scolopendra are 3 parts, the parts by weight of described Sanguis Draxonis are 40 parts, the parts by weight of described Radix Glycyrrhizae are 40 parts, the parts by weight of described Squama Manis are 40 parts, the parts by weight of described Os Draconis are 60 parts.
The Chinese medicine of described treatment prolapse of lumbar intervertebral disc, the parts by weight of described Flos Carthami are 50 parts, the parts by weight of described Radix Paeoniae Rubra are 50 parts, the parts by weight of described Olibanum are 30 parts, the parts by weight of described eupolyphage sece steleophaga are 30 parts, the parts by weight of described Radix Angelicae Sinensis are 30 parts, the parts by weight of described Rhizoma Chuanxiong are 30 parts, the parts by weight of described Radix Notoginseng are 50 parts, the parts by weight of described Rhizoma Corydalis are 30 parts, the parts by weight of described Radix Et Rhizoma Rhei are 30 parts, the parts by weight of described Pheretima are 30 parts, the parts by weight of described Radix Angelicae Pubescentis are 30 parts, the parts by weight of the described Cortex Eucommiae are 30 parts, the parts by weight of described Radix Aconiti Kusnezoffii are 30 parts, the parts by weight of described Spina Gleditsiae are 30 parts, the parts by weight of described Radix Achyranthis Bidentatae are 30 parts, the parts by weight of described Scolopendra are 2 parts, the parts by weight of described Sanguis Draxonis are 30 parts, the parts by weight of described Radix Glycyrrhizae are 30 parts, the parts by weight of described Squama Manis are 30 parts, the parts by weight of described Os Draconis are 50 parts.
A preparation method for the treatment of prolapse of lumbar intervertebral disc Chinese medicine, this preparation method comprises the steps:
Step 1: raw material of Chinese medicine micronizing 300 orders that take above-mentioned weight portion obtain medicated powder;
Step 2: ground medicated powder is put into container for stirring even;
Step 3: by first make the semifinished product of pill with an even Medical powder part, be called " mothers and sons ";
Step 4: " pill " is placed in mothers and sons in the general ball tank of sugar-coat tank of rotation, repeatedly sprays water, spreads pesticides, rotates sugar-coat tank, after medicated powder sticks on pill completely, sieves, and can be made into uniform and smooth water pill;
Step 5: water pill is placed on gravity-flow ventilation place cold drying, and temperature is controlled at 15-25 ℃, time 3-4 hour;
Step 6: water pill is made to pill, and every heavy 0.1 gram, 70 grams of every bags.
The preparation method of described treatment prolapse of lumbar intervertebral disc Chinese medicine, described mothers and sons are base particles of pill; With the molding of sugar-coat tank, make mother and sons' process and first use the cold boiled water of atomizers spray in sugar-coat tank, be then sprinkled into medicated powder, make tank rotation, after fine powder evenly adheres to, with brush by brushing down in the other direction with rotating photo in tank, now in tank to form many tiny medicines group, add again medicated powder, atomized water spray, rotation sugar-coat tank, repeatable operation like this, until form after the granule of suitable size, after sieve, choose uniform granule as mothers and sons.
Beneficial effect:
1. the present invention selects traditional Chinese herbal treatment prolapse of lumbar intervertebral disc disease, prolapse of lumbar intervertebral disc is a kind of of osteoarthritis, is a kind of disease causing due to bone degeneration, so in treatment prolapse of lumbar intervertebral disc, first to improve bony structures, supplement the required trace element of sclerotin.The traditional Chinese medical science think bone and liver,spleen,kidney in close relations, control the first the kidney invigorating of bone.Waist person, house of kidney, incapable of turning round, kidney is by exhausted.Carry < < Plain Questions-arteries and veins and want precise and tiny opinion > >.Kidney essense foot skeleton is nourished, and muscles and bones is strong and powerful.But the aging along with human body, liver spleen renal hypofunction, skeleton lose moisten foster, cause bone marrow sky to need, muscle arteries and veins loses supports the degeneration that occurs bone, cause articular degeneration, cause that lumbar intervertebral disc generation degeneration Anular disruption, vertebral pulp are outstanding, stimulate or tissue around of compressing and causing with lumbago.So want cautiously grasping pathogenesis during treatment, kidney tonifying marrow facilitating, Psoralen, strong waist knee joint, warming the meridian and promoting blood circulation, the removing damp and stopping pain of dispeling cold.Through the test of pesticide effectiveness and clinical showing: this medicine is evident in efficacy.
The present invention is according to pathogeny and the theory of Chinese medical science of lumbar vertebra prolapse of lumbar intervertebral disc disease, base oneself upon that to consolidate be main, by invigorating the liver and kidney, bone and muscle strengthening, promoting blood circulation by removing wind dredging collateral, the pain relieving of warming the meridian dampness removing, is conducive to improve compactness, the robustness of cartilaginous lamina after taking, adjust the full level of vertebral pulp moisture, make outstanding vertebral pulp Hui Na, the irritation of contact edema, removes the compressing of nerve root, repairs damage fibrous ring, thereby reach, delay regression or alleviate pathological changes definite effect, and short treating period, instant effect, is difficult for recurrence more afterwards.
The present invention's righting of getting rid of evils develops simultaneously, and treating both the principal and secondary aspects of a disease, is suitable for the lumbar disc disease that a variety of causes causes, and is particularly useful for prolapse of lumbar intervertebral disc, and has no adverse reaction and toxic and side effects.
Preparation of the present invention preparation is simple, and taking convenience is evident in efficacy, healing speed is fast.
Antiinflammatory result of the test of the present invention shows, treatment prolapse of lumbar intervertebral disc Chinese medicine administration group can delay Ovum Gallus domesticus album and cause pedal swelling, and self administration of medication more just has significant difference (P<0.05) with blank group in 1 hour.Prompting: Chinese medicine xylol, acetic acid and the Ovum Gallus domesticus album for the treatment of prolapse of lumbar intervertebral disc all have good antiinflammatory action.
Analgesic test of the present invention result shows, adopts acetic acid twisting method, and treatment prolapse of lumbar intervertebral disc Chinese medicine administration group has the effect of the pain of raising thresholding, and analgesia percentage rate is 31.3%.
Of the present invention the hemorheological result of the test that affects of rat syndrome of blood stasis model is shown: the hemorheological property effect that improves significantly for the treatment of prolapse of lumbar intervertebral disc Chinese medicine.
The specific embodiment:
Embodiment 1:
Treat a Chinese medicine for prolapse of lumbar intervertebral disc, its composition comprises: Flos Carthami, Radix Paeoniae Rubra, Olibanum, eupolyphage sece steleophaga, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Notoginseng, Rhizoma Corydalis, Radix Et Rhizoma Rhei, Pheretima, Radix Angelicae Pubescentis, the Cortex Eucommiae, Radix Aconiti Kusnezoffii, Spina Gleditsiae, Radix Achyranthis Bidentatae, Scolopendra, Sanguis Draxonis, Radix Glycyrrhizae, Squama Manis, Os Draconis, the parts by weight of described Flos Carthami are 40-60 part, the parts by weight of described Radix Paeoniae Rubra are 40-60 part, the parts by weight of described Olibanum are 20-40 part, the parts by weight of described eupolyphage sece steleophaga are 20-40 part, the parts by weight of described Radix Angelicae Sinensis are 20-40 part, the parts by weight of described Rhizoma Chuanxiong are 20-40 part, the parts by weight of described Radix Notoginseng are 40-60 part, the parts by weight of described Rhizoma Corydalis are 20-40 part, the parts by weight of described Radix Et Rhizoma Rhei are 20-40 part, the parts by weight of described Pheretima are 20-40 part, the parts by weight of described Radix Angelicae Pubescentis are 20-40 part, the parts by weight of the described Cortex Eucommiae are 20-40 part, the parts by weight of described Radix Aconiti Kusnezoffii are 20-40 part, the parts by weight of described Spina Gleditsiae are 20-40 part, the parts by weight of described Radix Achyranthis Bidentatae are 20-40 part, the parts by weight of described Scolopendra are 1-3 part, the parts by weight of described Sanguis Draxonis are 20-40 part, the parts by weight of described Radix Glycyrrhizae are 20-40 part, the parts by weight of described Squama Manis are 20-40 part, the parts by weight of described Os Draconis are 40-60 part.
By clinical observation on the therapeutic effect, test and set forth the curative effect of using this product.
One, physical data
Prolapse of lumbar intervertebral disc patient is respectively chosen to 30 routine patients, the prolapse of lumbar intervertebral disc patient who chooses is divided into two groups, every group of 15 people, distinguish as a control group and treatment group.
Two, diagnostic criteria
(1) symptom and sign
Patient's conscious waist persistence dull pain or spasm sample severe pain, horizontal position alleviates, the aggravation of standing, lower limb radiated pain.
(2) imaging examination
CT examination: CT examination image demonstrates the position of intervertebral disk hernia and the image that nerve root, dural sac pressurized are shifted, and demonstrates the situations such as vertebral plate and hypertrophy of ligamentum flavum, little joint hyperplasia hypertrophy, canalis spinalis and lateral recess stenosis simultaneously.
Three, Therapeutic Method:
Matched group: oral ibuprofen capsule: each 0.2 gram every day 3 times, 35 days is a course for the treatment of, one to three course for the treatment of.
Treatment group: oral Chinese medicine: each 5 grams, every day, twice sub-service sooner or later, 35 days was a course for the treatment of, one to three course for the treatment of.
Four, efficacy assessment standard
Cure: pain disappears, CT shows that the compactness of cartilaginous lamina improves, and outstanding vertebral pulp Hui Na, removes the compressing of nerve root, the annular repair of damage.
Effective: pain obviously alleviates, can orthobiosis and work.
Invalid: pain is not alleviated, after Long-term taking medicine, symptom does not change.
Five, therapeutic effect
Cure: 16 examples, effectively: 14 examples are invalid: 0 example, total effective rate reaches 100%.(referring to following statistical table)
Table 1 is statistical effect table:
Table 1
Treatment group takes medicine of the present invention and matched group is taken existing similar drug contrast, by above correction data, can find out, it is 27.00% to treatment prolapse of lumbar intervertebral disc cure rate that matched group is taken existing similar drug, effective percentage is 60.00%, and treatment group to take medicine of the present invention be 53.33% to treatment prolapse of lumbar intervertebral disc cure rate, effective percentage is 100%.
The healing patient of above-mentioned matched group, treatment group is paid a return visit once for every 6 months, through the return visit statistics of 3 years, in 8 people that matched group is cured, 4 people's recurrences accounted for 50%, unmanned recurrence in 16 people that treatment group is cured simultaneously.
Therefore a kind of drug products for the treatment of prolapse of lumbar intervertebral disc of the present invention to treatment prolapse of lumbar intervertebral disc cure rate and effective percentage equal existing similar drugs and without recurrence apparently higher than market.From above-mentioned every experimental studies results, a kind of medicine for the treatment of prolapse of lumbar intervertebral disc of the present invention can significantly reach the object for the treatment of prolapse of lumbar intervertebral disc.
Embodiment 2:
The Chinese medicine of the treatment prolapse of lumbar intervertebral disc described in embodiment 1, the parts by weight of described Flos Carthami are 45-55 part, the parts by weight of described Radix Paeoniae Rubra are 45-55 part, the parts by weight of described Olibanum are 25-35 part, the parts by weight of described eupolyphage sece steleophaga are 25-35 part, the parts by weight of described Radix Angelicae Sinensis are 25-35 part, the parts by weight of described Rhizoma Chuanxiong are 25-35 part, the parts by weight of described Radix Notoginseng are 45-55 part, the parts by weight of described Rhizoma Corydalis are 25-35 part, the parts by weight of described Radix Et Rhizoma Rhei are 25-35 part, the parts by weight of described Pheretima are 25-35 part, the parts by weight of described Radix Angelicae Pubescentis are 25-35 part, the parts by weight of the described Cortex Eucommiae are 25-35 part, the parts by weight of described Radix Aconiti Kusnezoffii are 25-35 part, the parts by weight of described Spina Gleditsiae are 25-35 part, the parts by weight of described Radix Achyranthis Bidentatae are 25-35 part, the parts by weight of described Scolopendra are 1-3 part, the parts by weight of described Sanguis Draxonis are 25-35 part, the parts by weight of described Radix Glycyrrhizae are 25-35 part, the parts by weight of described Squama Manis are 25-35 part, the parts by weight of described Os Draconis are 45-55 part.
Embodiment 3:
The Chinese medicine of the treatment prolapse of lumbar intervertebral disc described in embodiment 1, the parts by weight of described Flos Carthami are 40 parts, the parts by weight of described Radix Paeoniae Rubra are 40 parts, the parts by weight of described Olibanum are 20 parts, the parts by weight of described eupolyphage sece steleophaga are 20 parts, the parts by weight of described Radix Angelicae Sinensis are 20 parts, the parts by weight of described Rhizoma Chuanxiong are 20 parts, the parts by weight of described Radix Notoginseng are 40 parts, the parts by weight of described Rhizoma Corydalis are 20 parts, the parts by weight of described Radix Et Rhizoma Rhei are 20 parts, the parts by weight of described Pheretima are 20 parts, the parts by weight of described Radix Angelicae Pubescentis are 20 parts, the parts by weight of the described Cortex Eucommiae are 20 parts, the parts by weight of described Radix Aconiti Kusnezoffii are 20-40 part, the parts by weight of described Spina Gleditsiae are 20-40 part, the parts by weight of described Radix Achyranthis Bidentatae are 20 parts, the parts by weight of described Scolopendra are 1 part, the parts by weight of described Sanguis Draxonis are 20 parts, the parts by weight of described Radix Glycyrrhizae are 20 parts, the parts by weight of described Squama Manis are 20 parts, the parts by weight of described Os Draconis are 40 parts.
Embodiment 4:
The Chinese medicine of the treatment prolapse of lumbar intervertebral disc described in embodiment 1 or 2, the parts by weight of described Flos Carthami are 60 parts, the parts by weight of described Radix Paeoniae Rubra are 60 parts, the parts by weight of described Olibanum are 40 parts, the parts by weight of described eupolyphage sece steleophaga are 40 parts, the parts by weight of described Radix Angelicae Sinensis are 40 parts, the parts by weight of described Rhizoma Chuanxiong are 40 parts, the parts by weight of described Radix Notoginseng are 60 parts, the parts by weight of described Rhizoma Corydalis are 40 parts, the parts by weight of described Radix Et Rhizoma Rhei are 40 parts, the parts by weight of described Pheretima are 40 parts, the parts by weight of described Radix Angelicae Pubescentis are 40 parts, the parts by weight of the described Cortex Eucommiae are 40 parts, the parts by weight of described Radix Aconiti Kusnezoffii are 40 parts, the parts by weight of described Spina Gleditsiae are 40 parts, the parts by weight of described Radix Achyranthis Bidentatae are 40 parts, the parts by weight of described Scolopendra are 3 parts, the parts by weight of described Sanguis Draxonis are 40 parts, the parts by weight of described Radix Glycyrrhizae are 40 parts, the parts by weight of described Squama Manis are 40 parts, the parts by weight of described Os Draconis are 60 parts.
Embodiment 5:
The Chinese medicine of the treatment prolapse of lumbar intervertebral disc described in embodiment 1 or 2, the parts by weight of described Flos Carthami are 50 parts, the parts by weight of described Radix Paeoniae Rubra are 50 parts, the parts by weight of described Olibanum are 30 parts, the parts by weight of described eupolyphage sece steleophaga are 30 parts, the parts by weight of described Radix Angelicae Sinensis are 30 parts, the parts by weight of described Rhizoma Chuanxiong are 30 parts, the parts by weight of described Radix Notoginseng are 50 parts, the parts by weight of described Rhizoma Corydalis are 30 parts, the parts by weight of described Radix Et Rhizoma Rhei are 30 parts, the parts by weight of described Pheretima are 30 parts, the parts by weight of described Radix Angelicae Pubescentis are 30 parts, the parts by weight of the described Cortex Eucommiae are 30 parts, the parts by weight of described Radix Aconiti Kusnezoffii are 30 parts, the parts by weight of described Spina Gleditsiae are 30 parts, the parts by weight of described Radix Achyranthis Bidentatae are 30 parts, the parts by weight of described Scolopendra are 2 parts, the parts by weight of described Sanguis Draxonis are 30 parts, the parts by weight of described Radix Glycyrrhizae are 30 parts, the parts by weight of described Squama Manis are 30 parts, the parts by weight of described Os Draconis are 50 parts.
Embodiment 6:
A preparation method for the treatment of prolapse of lumbar intervertebral disc Chinese medicine, this preparation method comprises the steps:
Step 1: raw material of Chinese medicine micronizing 300 orders that take above-mentioned weight portion obtain medicated powder;
Step 2: ground medicated powder is put into container for stirring even;
Step 3: by first make the semifinished product of pill with an even Medical powder part, be called " mothers and sons ";
Step 4: " pill " is placed in mothers and sons in the general ball tank of sugar-coat tank of rotation, repeatedly sprays water, spreads pesticides, rotates sugar-coat tank, after medicated powder sticks on pill completely, sieves, and can be made into uniform and smooth water pill;
Step 5: water pill is placed on gravity-flow ventilation place cold drying, and temperature is controlled at 15-25 ℃, time 3-4 hour;
Step 6: water pill is made to pill, and every heavy 0.1 gram, 70 grams of every bags.
Embodiment 7:
The preparation method of the treatment prolapse of lumbar intervertebral disc Chinese medicine described in embodiment 6, described mothers and sons are base particles of pill; With the molding of sugar-coat tank, make mother and sons' process and first use the cold boiled water of atomizers spray in sugar-coat tank, be then sprinkled into medicated powder, make tank rotation, after fine powder evenly adheres to, with brush by brushing down in the other direction with rotating photo in tank, now in tank to form many tiny medicines group, add again medicated powder, atomized water spray, rotation sugar-coat tank, repeatable operation like this, until form after the granule of suitable size, after sieve, choose uniform granule as mothers and sons.
The present invention treats the Pharmacodynamic test of active extract of prolapse of lumbar intervertebral disc Chinese medicine
For checking treatment prolapse of lumbar intervertebral disc herbal medicine efficacy, learn characteristic, it carried out to antiinflammatory, analgesia pharmacodynamic experiment, now experimental result is reported as follows:
Experiment material
Medicine and reagent:
1, treatment prolapse of lumbar intervertebral disc Chinese medicine
2, positive control drug:
Ibuprofen manufacturing enterprise: Sino-America Tianjin Shike Pharmaceutical Co., Ltd.'s authentication code: the accurate word H10900089 of traditional Chinese medicines
Indomethacin manufacturing enterprise: Zhengzhou Huan Ke pharmaceutcal corporation, Ltd authentication code: the accurate word H41020112 of traditional Chinese medicines
Adrenalin hydrochloride injection: manufacturing enterprise: Shanghai Hefeng Pharmaceutical Co., Ltd. produces, the accurate word H31021062 of traditional Chinese medicines, lot number: 100712
Animal: white mice is Kunming kind, rat is SD kind, by Heilongjiang University of Chinese Medicine's Experimental Animal Center, provides.The quality certification: 07-3-3.
Method and result
One, the impact on mice ear
Principle: cause after auricular concha skin turgor with proinflammatory agent, observe and measure the weight that administration group and matched group cause scorching auricular concha, and compare the difference of their swelling rate.
Operational approach:
1. get 50 of Male Kunming strain mice (18 ~ 20g), be divided at random 5 groups, 10 every group.
2. equal gastric infusion, Chinese drug-treated group drug treatment every day prolapse of lumbar intervertebral disc Chinese medicine 3g/kg, 6g/kg, 12g/kg, indomethacin matched group every day is to indomethacin 8mg/kg, and blank group is given 0.9% normal saline (NS) 0.3ml/10g every day.For three days on end, after the 3rd day gavage 1 hour, under etherization, before and after the left ear of mice, two sides is coated with the about 0.1ml of 100% dimethylbenzene, auris dextra is done blank.
3. after 1h, the disconnected neck of mice is put to death, along auricle baseline, cut two ears, with 9mm diameter card punch, at same position, lay round auricle respectively, with organizing balance to weigh.The left auricle weight of every Mus deducts auris dextra sheet weight and is swelling degree.(left auricle weight-auris dextra sheet weight)/auris dextra sheet weight is as swelling rate.Calculate average and the standard deviation of each swollen tissue, by aforementioned formula, obtain the inhibitory rate of intumesce of administration group, and make t test, the significance of difference between comparable group.Result indomethacin group inhibitory rate of intumesce is 45.14%, and Chinese medicine high dose group inhibitory rate of intumesce is 83.62%, and in Chinese medicine, dosage group inhibitory rate of intumesce is 69.37%, and Chinese medicine low dose group inhibitory rate of intumesce is 60.28%.Learn and process by statistics, relatively, all there were significant differences (p < 0.05) for indomethacin group, Chinese drug-treated group and blank group; Indomethacin group and Chinese drug-treated group be no significant difference (p > 0.05) relatively.
Evaluate: this law is easy and simple to handle, does not need special installation, instant effect, dosage is few, is applicable to the screening of anti-inflammatory agent.
Lime light:
1. the position that the auricle taking off should cause scorching liquid with painting matches.
2. tested medicine is more reasonable with whole body administration, and the influence factor of local application is more, may occur false positive.
The impact of table 2 treatment prolapse of lumbar intervertebral disc Chinese medicine on mice ear
Note: with model control group, compare * P<0.05 * * P<0.01
As can be seen here, treatment prolapse of lumbar intervertebral disc Chinese medicine 3g crude drug/kg, 6g crude drug/kg, 12g crude drug/kg xylol induced mice ear swelling has remarkable inhibitory action.
Above-mentioned the results show, treatment prolapse of lumbar intervertebral disc Chinese medicine administration group and positive drug group have obvious antiinflammatory action, and the 1h effect after proinflammatory agent of administration group is the most obvious.
Two, the impact on rat paw edema
Get body weight and be 50 of the male rats of 140 ~ 160 g, by body weight, divide 5 groups at random, every group 10, be respectively dosage group, treatment prolapse of lumbar intervertebral disc Chinese medicine low dose group, indomethacin group in saline group, treatment prolapse of lumbar intervertebral disc Chinese medicine high dose group, treatment prolapse of lumbar intervertebral disc Chinese medicine.Equal gastric infusions, Chinese drug-treated group drug treatment every day prolapse of lumbar intervertebral disc Chinese medicine 3g/kg, 6g/kg, 12g/kg, indomethacin matched group every day is to indomethacin 8mg/kg, and blank group is given 0.9% normal saline (NS) 0.3ml/10g every day.Before experiment, at the right back ankle joint of each Mus, mark, with sufficient volume measuring apparatus, measure each Mus right hind foot volume twice, average as normal foot volume.30min after administration, every clear solution 0.1ml of subcutaneous injection 10% Fresh Egg of Rat Right metapedes sole of the foot portion causes inflammation, respectively at causing scorching rear 0.5h, 1h, 2h, 4h, 6h, measures and causes scorching sufficient volume, calculates each rat and causes scorching front and back, right back sufficient sole of the foot volume-variation value.The results are shown in following table 3.
The impact (X ± s, n=10) of table 3 treatment prolapse of lumbar intervertebral disc Chinese medicine test sample on foot swelling due to Ovum Gallus domesticus album
From experimental result, during the 0.5h to 6h after administration, to compare with saline group, the foot swelling rate of each administration group all obviously reduces, wherein remarkable with high dose group diversity.1h after administration, high, medium and low dosage group and saline group relatively have obvious diversity, and high dose and saline group relatively have extremely significantly diversity; 2h after administration, high, medium and low dosage group and saline group relatively have obvious diversity; After administration, 4h is similar with 6h situation, and high, medium and low dosage group and saline group relatively have obvious diversity
Three, hot-plate analgesic test
Choose pain territory 50 of the mices of 5 ~ 30s, by basis pain thresholding, be divided at random 5 groups, every group 10, equal gastric infusion, Chinese drug-treated group drug treatment every day prolapse of lumbar intervertebral disc Chinese medicine 3g/kg, 6g/kg, 12g/kg, ibuprofen matched group every day is to ibuprofen 8mg/kg, and blank group is given 0.9% normal saline (NS) 0.3ml/10g every day.After administration 0.5,1,1.5h is measured in the same method each Mus pain thresholding, the results are shown in Table
From table 4, the pain reaction that treatment prolapse of lumbar intervertebral disc Chinese medicine 3g crude drug/kg, 6g crude drug/kg, 12g crude drug/kg cause thermostimulation mice has obvious inhibitory action.
The impact of table 4 treatment prolapse of lumbar intervertebral disc Chinese medicine on mice thermostimulation reaction
Four, to the analgesic activity of white mice (writhing method)
Get 50 of Kunming kind white mice (male), be divided at random 5 groups, every group 10, it is all the same that each organizes medication, medication, dosage, for three days on end, after perfusion in the 3rd day 30 minutes, 0.6% acetate solution 0.2ml is all injected in each Mus abdominal cavity, observe to inject in latter 30 minutes and occur that writhing response (stretches hind leg, abdominal part shrinks indent, buttocks is raised) number of mice, calculate analgesia Shuai ﹝ analgesia rate=(experimental group without writhing response number of animals-matched group without writhing response number of animals)/matched group writhing response Dong Wu and Shuo ﹞, the results are shown in Table 5.
Table 5 treatment prolapse of lumbar intervertebral disc Chinese medicine Dichlorodiphenyl Acetate causes the impact of the pain reaction of mice
From table 5, treatment prolapse of lumbar intervertebral disc Chinese medicine 3g crude drug/kg, 6g crude drug/kg, 12g crude drug/kg Dichlorodiphenyl Acetate cause that the pain reaction of mice has obvious inhibitory action.
Five, on the hemorheological impact of rat syndrome of blood stasis model
1, experiment grouping SD rat is 48, male and female half and half, and body weight 180 ~ 220g, is divided into six groups at random, eight every group, establishes blank group, model group, positive controls, the large, medium and small dosage group for the treatment of prolapse of lumbar intervertebral disc Chinese medicine.
, method Normal group and model group gavage distilled water, FUFANG DANSHEN PIAN group gavage 0.782g/ kg, 4th ~ 6 groups of gavage treatment every day prolapse of lumbar intervertebral disc Chinese medicine 12g, 6g, 3g crude drug/kg, once a day, continuous 5 days, 1h after last administration, except blank group, all the other only respectively organize equal subcutaneous injection adrenalin hydrochloride 0.15 mg/, after injection 2h, below respectively organize rat and all immerse 5min in 4 ℃ of frozen water, after taking-up, dry the water on rat fur, only after 2h, respectively organize again subcutaneous injection adrenalin hydrochloride 0.15 mg/, water 18h is can't help in fasting, with 10 ﹪ urethane 1mL/100g intraperitoneal injection of anesthesia, separated common carotid artery, intubate is got blood 5 mL, make blood naturally flow into the test tube containing a small amount of heparin sodium, shake on stream limit, limit, make blood anticoagulant, on the full-automatic blood rheology test instrument of ZL4500i, detect, 22 ℃ of room temperatures, 37 ℃ of sample constant temperature.
, this group of result test data
± s represents relatively to take t check between group, take P < 0.05 as significant difference, and P < 0.01 is utmost point significant difference.Statistical procedures adopts Excel2003.Result of the test sees the following form.
Model group whole blood viscosity value (200mpa.s), whole blood viscosity value (30mpa.s), whole blood viscosity value (5mpa.s), whole blood viscosity value (1mpa.s), plasma viscosity, Fibrinogen and erythrocyte overstock all apparently higher than blank group (P < 0.01～P < 0.05), and blood stasis model success is described, FUFANG DANSHEN PIAN group and treatment prolapse of lumbar intervertebral disc Chinese medicine 12g, 6g crude drug/kg group can significantly reduce whole blood viscosity value (200mpa.s, 30mpa.s, 5mpa.s, 1mpa.s) plasma viscosity and Fibrinogen (P < 0.01～P < 0.05), FUFANG DANSHEN PIAN group and treatment prolapse of lumbar intervertebral disc Chinese medicine 12g, crude drug/kg group can significantly reduce packed cell volume (P < 0.01), treatment prolapse of lumbar intervertebral disc Chinese medicine 3g crude drug/kg also can obviously reduce whole blood viscosity value (200mpa.s, 30mpa.s, 5mpa.s, 1mpa.s) plasma viscosity and Fibrinogen (P < 0.01～P < 0.05), result shows this product hemorheological property effect that improves significantly.
Table 6 treatment prolapse of lumbar intervertebral disc Chinese medicine is on the hemorheological impact of rat syndrome of blood stasis model
Note: with blank group comparison: △ P < 0.01; With model control group comparison: ▲ P < 0.05, ◇ P < 0.01.
Table 7 treatment prolapse of lumbar intervertebral disc Chinese medicine on the hemorheological impact of rat syndrome of blood stasis model (
± s)
Note: with blank group comparison: △ P < 0.01; With model control group comparison: ▲ P < 0.05, ◇ P < 0.01.
Table 8 treatment prolapse of lumbar intervertebral disc Chinese medicine on the hemorheological impact of rat syndrome of blood stasis model (
± s)
Note: with blank group comparison: △ P < 0.01; With model control group comparison: ▲ P < 0.05, ◇ P < 0.01.
Antiinflammatory result of the test shows, treatment prolapse of lumbar intervertebral disc Chinese medicine administration group can delay Ovum Gallus domesticus album and cause pedal swelling, and self administration of medication more just has significant difference (P<0.05) with blank group in 1 hour.Prompting: Chinese medicine xylol, acetic acid and the Ovum Gallus domesticus album for the treatment of prolapse of lumbar intervertebral disc all have good antiinflammatory action.
Analgesic test result shows, adopts acetic acid twisting method, and treatment prolapse of lumbar intervertebral disc Chinese medicine administration group has the effect of the pain of raising thresholding, and analgesia percentage rate is 31.3%.
The hemorheological result of the test that affects of rat syndrome of blood stasis model is shown: the hemorheological property effect that improves significantly for the treatment of prolapse of lumbar intervertebral disc Chinese medicine.
Claims (7)
1. treat a Chinese medicine for prolapse of lumbar intervertebral disc, its composition comprises: Flos Carthami, Radix Paeoniae Rubra, Olibanum, eupolyphage sece steleophaga, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Notoginseng, Rhizoma Corydalis, Radix Et Rhizoma Rhei, Pheretima, Radix Angelicae Pubescentis, the Cortex Eucommiae, Radix Aconiti Kusnezoffii, Spina Gleditsiae, Radix Achyranthis Bidentatae, Scolopendra, Sanguis Draxonis, Radix Glycyrrhizae, Squama Manis, Os Draconis, it is characterized in that: the parts by weight of described Flos Carthami are 40-60 part, the parts by weight of described Radix Paeoniae Rubra are 40-60 part, the parts by weight of described Olibanum are 20-40 part, the parts by weight of described eupolyphage sece steleophaga are 20-40 part, the parts by weight of described Radix Angelicae Sinensis are 20-40 part, the parts by weight of described Rhizoma Chuanxiong are 20-40 part, the parts by weight of described Radix Notoginseng are 40-60 part, the parts by weight of described Rhizoma Corydalis are 20-40 part, the parts by weight of described Radix Et Rhizoma Rhei are 20-40 part, the parts by weight of described Pheretima are 20-40 part, the parts by weight of described Radix Angelicae Pubescentis are 20-40 part, the parts by weight of the described Cortex Eucommiae are 20-40 part, the parts by weight of described Radix Aconiti Kusnezoffii are 20-40 part, the parts by weight of described Spina Gleditsiae are 20-40 part, the parts by weight of described Radix Achyranthis Bidentatae are 20-40 part, the parts by weight of described Scolopendra are 1-3 part, the parts by weight of described Sanguis Draxonis are 20-40 part, the parts by weight of described Radix Glycyrrhizae are 20-40 part, the parts by weight of described Squama Manis are 20-40 part, the parts by weight of described Os Draconis are 40-60 part.
2. the Chinese medicine for the treatment of prolapse of lumbar intervertebral disc according to claim 1, it is characterized in that: the parts by weight of described Flos Carthami are 45-55 part, the parts by weight of described Radix Paeoniae Rubra are 45-55 part, the parts by weight of described Olibanum are 25-35 part, the parts by weight of described eupolyphage sece steleophaga are 25-35 part, the parts by weight of described Radix Angelicae Sinensis are 25-35 part, the parts by weight of described Rhizoma Chuanxiong are 25-35 part, the parts by weight of described Radix Notoginseng are 45-55 part, the parts by weight of described Rhizoma Corydalis are 25-35 part, the parts by weight of described Radix Et Rhizoma Rhei are 25-35 part, the parts by weight of described Pheretima are 25-35 part, the parts by weight of described Radix Angelicae Pubescentis are 25-35 part, the parts by weight of the described Cortex Eucommiae are 25-35 part, the parts by weight of described Radix Aconiti Kusnezoffii are 25-35 part, the parts by weight of described Spina Gleditsiae are 25-35 part, the parts by weight of described Radix Achyranthis Bidentatae are 25-35 part, the parts by weight of described Scolopendra are 1-3 part, the parts by weight of described Sanguis Draxonis are 25-35 part, the parts by weight of described Radix Glycyrrhizae are 25-35 part, the parts by weight of described Squama Manis are 25-35 part, the parts by weight of described Os Draconis are 45-55 part.
3. the Chinese medicine for the treatment of prolapse of lumbar intervertebral disc according to claim 1, it is characterized in that: the parts by weight of described Flos Carthami are 40 parts, the parts by weight of described Radix Paeoniae Rubra are 40 parts, the parts by weight of described Olibanum are 20 parts, the parts by weight of described eupolyphage sece steleophaga are 20 parts, the parts by weight of described Radix Angelicae Sinensis are 20 parts, the parts by weight of described Rhizoma Chuanxiong are 20 parts, the parts by weight of described Radix Notoginseng are 40 parts, the parts by weight of described Rhizoma Corydalis are 20 parts, the parts by weight of described Radix Et Rhizoma Rhei are 20 parts, the parts by weight of described Pheretima are 20 parts, the parts by weight of described Radix Angelicae Pubescentis are 20 parts, the parts by weight of the described Cortex Eucommiae are 20 parts, the parts by weight of described Radix Aconiti Kusnezoffii are 20-40 part, the parts by weight of described Spina Gleditsiae are 20-40 part, the parts by weight of described Radix Achyranthis Bidentatae are 20 parts, the parts by weight of described Scolopendra are 1 part, the parts by weight of described Sanguis Draxonis are 20 parts, the parts by weight of described Radix Glycyrrhizae are 20 parts, the parts by weight of described Squama Manis are 20 parts, the parts by weight of described Os Draconis are 40 parts.
4. the Chinese medicine for the treatment of prolapse of lumbar intervertebral disc according to claim 1, it is characterized in that: the parts by weight of described Flos Carthami are 60 parts, the parts by weight of described Radix Paeoniae Rubra are 60 parts, the parts by weight of described Olibanum are 40 parts, the parts by weight of described eupolyphage sece steleophaga are 40 parts, the parts by weight of described Radix Angelicae Sinensis are 40 parts, the parts by weight of described Rhizoma Chuanxiong are 40 parts, the parts by weight of described Radix Notoginseng are 60 parts, the parts by weight of described Rhizoma Corydalis are 40 parts, the parts by weight of described Radix Et Rhizoma Rhei are 40 parts, the parts by weight of described Pheretima are 40 parts, the parts by weight of described Radix Angelicae Pubescentis are 40 parts, the parts by weight of the described Cortex Eucommiae are 40 parts, the parts by weight of described Radix Aconiti Kusnezoffii are 40 parts, the parts by weight of described Spina Gleditsiae are 40 parts, the parts by weight of described Radix Achyranthis Bidentatae are 40 parts, the parts by weight of described Scolopendra are 3 parts, the parts by weight of described Sanguis Draxonis are 40 parts, the parts by weight of described Radix Glycyrrhizae are 40 parts, the parts by weight of described Squama Manis are 40 parts, the parts by weight of described Os Draconis are 60 parts.
5. the Chinese medicine for the treatment of prolapse of lumbar intervertebral disc according to claim 1 and 2, it is characterized in that: the parts by weight of described Flos Carthami are 50 parts, the parts by weight of described Radix Paeoniae Rubra are 50 parts, the parts by weight of described Olibanum are 30 parts, the parts by weight of described eupolyphage sece steleophaga are 30 parts, the parts by weight of described Radix Angelicae Sinensis are 30 parts, the parts by weight of described Rhizoma Chuanxiong are 30 parts, the parts by weight of described Radix Notoginseng are 50 parts, the parts by weight of described Rhizoma Corydalis are 30 parts, the parts by weight of described Radix Et Rhizoma Rhei are 30 parts, the parts by weight of described Pheretima are 30 parts, the parts by weight of described Radix Angelicae Pubescentis are 30 parts, the parts by weight of the described Cortex Eucommiae are 30 parts, the parts by weight of described Radix Aconiti Kusnezoffii are 30 parts, the parts by weight of described Spina Gleditsiae are 30 parts, the parts by weight of described Radix Achyranthis Bidentatae are 30 parts, the parts by weight of described Scolopendra are 2 parts, the parts by weight of described Sanguis Draxonis are 30 parts, the parts by weight of described Radix Glycyrrhizae are 30 parts, the parts by weight of described Squama Manis are 30 parts, the parts by weight of described Os Draconis are 50 parts.
6. a preparation method for the treatment of prolapse of lumbar intervertebral disc Chinese medicine, is characterized in that: this preparation method comprises the steps:
Step 1: raw material of Chinese medicine micronizing 300 orders that take above-mentioned weight portion obtain medicated powder;
Step 2: ground medicated powder is put into container for stirring even;
Step 3: by first make the semifinished product of pill with an even Medical powder part, be called " mothers and sons ";
Step 4: " pill " is placed in mothers and sons in the general ball tank of sugar-coat tank of rotation, repeatedly sprays water, spreads pesticides, rotates sugar-coat tank, after medicated powder sticks on pill completely, sieves, and can be made into uniform and smooth water pill;
Step 5: water pill is placed on gravity-flow ventilation place cold drying, and temperature is controlled at 15-25 ℃, time 3-4 hour;
Step 6: water pill is made to pill, and every heavy 0.1 gram, 70 grams of every bags.
7. the preparation method for the treatment of prolapse of lumbar intervertebral disc Chinese medicine according to claim 6, is characterized in that: described mothers and sons are base particles of pill; With the molding of sugar-coat tank, make mother and sons' process and first use the cold boiled water of atomizers spray in sugar-coat tank, be then sprinkled into medicated powder, make tank rotation, after fine powder evenly adheres to, with brush by brushing down in the other direction with rotating photo in tank, now in tank to form many tiny medicines group, add again medicated powder, atomized water spray, rotation sugar-coat tank, repeatable operation like this, until form after the granule of suitable size, after sieve, choose uniform granule as mothers and sons.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310624721.5A CN103623184B (en) | 2013-11-30 | 2013-11-30 | The Chinese medicine for the treatment of prolapse of lumbar intervertebral disc and manufacture method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310624721.5A CN103623184B (en) | 2013-11-30 | 2013-11-30 | The Chinese medicine for the treatment of prolapse of lumbar intervertebral disc and manufacture method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103623184A true CN103623184A (en) | 2014-03-12 |
| CN103623184B CN103623184B (en) | 2016-01-20 |
Family
ID=50204867
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310624721.5A Expired - Fee Related CN103623184B (en) | 2013-11-30 | 2013-11-30 | The Chinese medicine for the treatment of prolapse of lumbar intervertebral disc and manufacture method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103623184B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104606511A (en) * | 2015-02-09 | 2015-05-13 | 齐刚 | Traditional Chinese medicine for preventing postoperative bounce phenomenon after minimally invasive therapy on lubar intervertebral disc protrusion |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1365827A (en) * | 2002-02-04 | 2002-08-28 | 陈玉周 | Exterior-applied medicine for treating osteopathy |
| CN103356854A (en) * | 2013-07-23 | 2013-10-23 | 董恩荣 | Traditional Chinese medicine for treating rheumatism |
-
2013
- 2013-11-30 CN CN201310624721.5A patent/CN103623184B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1365827A (en) * | 2002-02-04 | 2002-08-28 | 陈玉周 | Exterior-applied medicine for treating osteopathy |
| CN103356854A (en) * | 2013-07-23 | 2013-10-23 | 董恩荣 | Traditional Chinese medicine for treating rheumatism |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104606511A (en) * | 2015-02-09 | 2015-05-13 | 齐刚 | Traditional Chinese medicine for preventing postoperative bounce phenomenon after minimally invasive therapy on lubar intervertebral disc protrusion |
| CN104606511B (en) * | 2015-02-09 | 2018-01-26 | 齐刚 | A kind of Chinese medicine for preventing minimally-invasive treatment Lumbar Disc herniation resection rebound phenomenon |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103623184B (en) | 2016-01-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104825591A (en) | Traditional Chinese medicine preparation for treating cervical vertebra diseases and preparation method of traditional Chinese medicine preparation | |
| CN103263659B (en) | Traditional Chinese medicine composition for treating rheumatism bone diseases | |
| CN103394031B (en) | Medicament for treating sciatica | |
| CN102309723A (en) | Traditional Chinese medicine composition for treating arthralgia and preparation method of ointment thereof | |
| CN104258278A (en) | Gushangling (for bone injury) spray | |
| CN102247501A (en) | Medicine for treating soft tissue injury | |
| CN103393999A (en) | Anti-inflammatory resolutive liquid medicine for promoting blood circulation to arrest pain | |
| CN103520682A (en) | Traditional Chinese medicine composition for treating rheumatism bone disease | |
| CN103495042A (en) | Traditional Chinese medicine composition for treating migraine | |
| CN103565969A (en) | Traditional Chinese medicine composition for treating soft tissue injury and fracture | |
| CN105288232A (en) | Traditional Chinese medicine capsule for treating rheumatic bone disease and preparing method thereof | |
| CN107115493A (en) | It is a kind of to treat Chinese medicine composition of fracture and its production and use | |
| CN103623184B (en) | The Chinese medicine for the treatment of prolapse of lumbar intervertebral disc and manufacture method | |
| CN105362904A (en) | Qi tonifying and blood nourishing traditional Chinese medicinal pill and preparation method thereof | |
| CN104162088A (en) | Traditional Chinese medicine composition for relieving rigidity of muscles, activating collaterals and eliminating dampness and preparation method thereof | |
| CN105343419A (en) | Traditional Chinese medicinal pill for invigorating yang and tonifying kidney, and preparation method thereof | |
| CN104958416A (en) | Chinese medicinal preparation for treating sciatica and preparation method thereof | |
| CN105597035A (en) | Application of externally-applied traditional Chinese medicine preparation in preparation of medicines for treating hyperosteogeny | |
| CN101564433B (en) | Chinese medicinal composition for treating rheumatic diseases, and preparation method thereof | |
| CN108743818A (en) | External application is dispelled osteoarthropathy medicinal liquor | |
| CN102335304B (en) | Chinese medicine composition for dispelling wind, removing dampness, invigorating blood circulation, and relieving pain and preparation method thereof | |
| CN107875200A (en) | A kind of Chinese medicine composition of effectively treatment tinea pedis | |
| CN101897822B (en) | Traditional Chinese medicinal preparation for treating hyperosteogeny and prolapse of intervertebral discs and preparation method thereof | |
| CN101658648B (en) | Medicament for treating cervical erosion | |
| CN105106786A (en) | Traditional Chinese medicine composition capable of dredging collaterals and relaxing muscles as well as preparation and production method of composition |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20160120 Termination date: 20161130 |