CN103622017A - 灵芝蛹虫草颗粒 - Google Patents
灵芝蛹虫草颗粒 Download PDFInfo
- Publication number
- CN103622017A CN103622017A CN201310625442.0A CN201310625442A CN103622017A CN 103622017 A CN103622017 A CN 103622017A CN 201310625442 A CN201310625442 A CN 201310625442A CN 103622017 A CN103622017 A CN 103622017A
- Authority
- CN
- China
- Prior art keywords
- mass parts
- extract
- glossy ganoderma
- cordyceps militaris
- parts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 241001264174 Cordyceps militaris Species 0.000 title claims abstract description 19
- 240000008397 Ganoderma lucidum Species 0.000 title abstract description 5
- 235000001637 Ganoderma lucidum Nutrition 0.000 title abstract 4
- 239000008187 granular material Substances 0.000 title abstract 3
- 239000000284 extract Substances 0.000 claims abstract description 47
- 239000000463 material Substances 0.000 claims abstract description 21
- 244000197580 Poria cocos Species 0.000 claims abstract description 20
- 235000008599 Poria cocos Nutrition 0.000 claims abstract description 20
- 239000000843 powder Substances 0.000 claims abstract description 16
- 241000234435 Lilium Species 0.000 claims abstract description 11
- 229920002774 Maltodextrin Polymers 0.000 claims abstract description 10
- 239000005913 Maltodextrin Substances 0.000 claims abstract description 10
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims abstract description 10
- 229940035034 maltodextrin Drugs 0.000 claims abstract description 10
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims abstract description 10
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims abstract description 10
- 229960002675 xylitol Drugs 0.000 claims abstract description 10
- 235000010447 xylitol Nutrition 0.000 claims abstract description 10
- 239000000811 xylitol Substances 0.000 claims abstract description 10
- 241000222336 Ganoderma Species 0.000 claims description 28
- 239000003814 drug Substances 0.000 claims description 14
- 240000008866 Ziziphus nummularia Species 0.000 claims description 13
- 235000001188 Peltandra virginica Nutrition 0.000 claims description 12
- 239000012141 concentrate Substances 0.000 claims description 12
- 238000001035 drying Methods 0.000 claims description 12
- 239000006228 supernatant Substances 0.000 claims description 12
- 239000002245 particle Substances 0.000 claims description 11
- KQLDDLUWUFBQHP-UHFFFAOYSA-N Cordycepin Natural products C1=NC=2C(N)=NC=NC=2N1C1OCC(CO)C1O KQLDDLUWUFBQHP-UHFFFAOYSA-N 0.000 claims description 10
- OFEZSBMBBKLLBJ-BAJZRUMYSA-N cordycepin Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)C[C@H]1O OFEZSBMBBKLLBJ-BAJZRUMYSA-N 0.000 claims description 10
- OFEZSBMBBKLLBJ-UHFFFAOYSA-N cordycepine Natural products C1=NC=2C(N)=NC=NC=2N1C1OC(CO)CC1O OFEZSBMBBKLLBJ-UHFFFAOYSA-N 0.000 claims description 10
- 229940079593 drug Drugs 0.000 claims description 9
- 229930182490 saponin Natural products 0.000 claims description 9
- 150000007949 saponins Chemical class 0.000 claims description 9
- 239000001397 quillaja saponaria molina bark Substances 0.000 claims description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 6
- 239000008213 purified water Substances 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- 241001247821 Ziziphus Species 0.000 claims description 5
- 239000001394 sodium malate Substances 0.000 claims description 4
- 230000000694 effects Effects 0.000 abstract description 16
- 230000036039 immunity Effects 0.000 abstract description 11
- 230000002708 enhancing effect Effects 0.000 abstract description 3
- 239000002994 raw material Substances 0.000 abstract description 2
- 230000003860 sleep quality Effects 0.000 abstract 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 11
- 230000007958 sleep Effects 0.000 description 11
- 230000036737 immune function Effects 0.000 description 7
- 235000017709 saponins Nutrition 0.000 description 7
- 241000699670 Mus sp. Species 0.000 description 6
- 244000000231 Sesamum indicum Species 0.000 description 4
- 235000003434 Sesamum indicum Nutrition 0.000 description 4
- 230000008485 antagonism Effects 0.000 description 4
- 230000006870 function Effects 0.000 description 4
- 230000036541 health Effects 0.000 description 4
- 230000000242 pagocytic effect Effects 0.000 description 4
- KWTSXDURSIMDCE-QMMMGPOBSA-N (S)-amphetamine Chemical compound C[C@H](N)CC1=CC=CC=C1 KWTSXDURSIMDCE-QMMMGPOBSA-N 0.000 description 3
- 244000025254 Cannabis sativa Species 0.000 description 3
- 206010039897 Sedation Diseases 0.000 description 3
- 241000256856 Vespidae Species 0.000 description 3
- 229940025084 amphetamine Drugs 0.000 description 3
- 230000005284 excitation Effects 0.000 description 3
- 210000004698 lymphocyte Anatomy 0.000 description 3
- 210000002540 macrophage Anatomy 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 230000036280 sedation Effects 0.000 description 3
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 241000233866 Fungi Species 0.000 description 2
- 108010006464 Hemolysin Proteins Proteins 0.000 description 2
- 206010020751 Hypersensitivity Diseases 0.000 description 2
- 240000001307 Myosotis scorpioides Species 0.000 description 2
- 208000026935 allergic disease Diseases 0.000 description 2
- 230000007815 allergy Effects 0.000 description 2
- VIROVYVQCGLCII-UHFFFAOYSA-N amobarbital Chemical compound CC(C)CCC1(CC)C(=O)NC(=O)NC1=O VIROVYVQCGLCII-UHFFFAOYSA-N 0.000 description 2
- 230000001147 anti-toxic effect Effects 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 230000001413 cellular effect Effects 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 230000003111 delayed effect Effects 0.000 description 2
- 210000003743 erythrocyte Anatomy 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 239000003228 hemolysin Substances 0.000 description 2
- 230000004727 humoral immunity Effects 0.000 description 2
- 230000001900 immune effect Effects 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 239000000932 sedative agent Substances 0.000 description 2
- 230000001624 sedative effect Effects 0.000 description 2
- 210000000952 spleen Anatomy 0.000 description 2
- 230000008925 spontaneous activity Effects 0.000 description 2
- 210000001541 thymus gland Anatomy 0.000 description 2
- 230000002936 tranquilizing effect Effects 0.000 description 2
- 238000003809 water extraction Methods 0.000 description 2
- DNXIKVLOVZVMQF-UHFFFAOYSA-N (3beta,16beta,17alpha,18beta,20alpha)-17-hydroxy-11-methoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]-yohimban-16-carboxylic acid, methyl ester Natural products C1C2CN3CCC(C4=CC=C(OC)C=C4N4)=C4C3CC2C(C(=O)OC)C(O)C1OC(=O)C1=CC(OC)=C(OC)C(OC)=C1 DNXIKVLOVZVMQF-UHFFFAOYSA-N 0.000 description 1
- 240000002900 Arthrospira platensis Species 0.000 description 1
- 235000016425 Arthrospira platensis Nutrition 0.000 description 1
- 241000235349 Ascomycota Species 0.000 description 1
- 206010003694 Atrophy Diseases 0.000 description 1
- 229920000018 Callose Polymers 0.000 description 1
- 241001480006 Clavicipitaceae Species 0.000 description 1
- 206010010904 Convulsion Diseases 0.000 description 1
- 241000190633 Cordyceps Species 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 description 1
- AEMOLEFTQBMNLQ-AQKNRBDQSA-N D-glucopyranuronic acid Chemical compound OC1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-AQKNRBDQSA-N 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 description 1
- 241000238631 Hexapoda Species 0.000 description 1
- 241000221775 Hypocreales Species 0.000 description 1
- SQHQDXGIJPHZRZ-AAWDLAKASA-N Jujuboside A Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](O[C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O3)O)O2)O[C@H]2[C@@H]([C@@H](O)[C@H](O)CO2)O)[C@@H](O)CO[C@H]1O[C@@H]1C(C)(C)[C@H](CC[C@@]2(C)[C@@]34C[C@]5([C@H]([C@@](C[C@@H](O5)C=C)(C)O)[C@H]4CC[C@H]42)OC3)[C@]4(C)CC1 SQHQDXGIJPHZRZ-AAWDLAKASA-N 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 206010033557 Palpitations Diseases 0.000 description 1
- 240000005373 Panax quinquefolius Species 0.000 description 1
- 235000003140 Panax quinquefolius Nutrition 0.000 description 1
- CWRVKFFCRWGWCS-UHFFFAOYSA-N Pentrazole Chemical compound C1CCCCC2=NN=NN21 CWRVKFFCRWGWCS-UHFFFAOYSA-N 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- 241000222341 Polyporaceae Species 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- 208000001431 Psychomotor Agitation Diseases 0.000 description 1
- 241000382353 Pupa Species 0.000 description 1
- LCQMZZCPPSWADO-UHFFFAOYSA-N Reserpilin Natural products COC(=O)C1COCC2CN3CCc4c([nH]c5cc(OC)c(OC)cc45)C3CC12 LCQMZZCPPSWADO-UHFFFAOYSA-N 0.000 description 1
- QEVHRUUCFGRFIF-SFWBKIHZSA-N Reserpine Natural products O=C(OC)[C@@H]1[C@H](OC)[C@H](OC(=O)c2cc(OC)c(OC)c(OC)c2)C[C@H]2[C@@H]1C[C@H]1N(C2)CCc2c3c([nH]c12)cc(OC)cc3 QEVHRUUCFGRFIF-SFWBKIHZSA-N 0.000 description 1
- 206010038743 Restlessness Diseases 0.000 description 1
- 241000612118 Samolus valerandi Species 0.000 description 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 1
- 206010041660 Splenomegaly Diseases 0.000 description 1
- 210000000662 T-lymphocyte subset Anatomy 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 229960001301 amobarbital Drugs 0.000 description 1
- 230000002567 autonomic effect Effects 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical group OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 230000007969 cellular immunity Effects 0.000 description 1
- 210000003169 central nervous system Anatomy 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 230000036461 convulsion Effects 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 231100000673 dose–response relationship Toxicity 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000000469 ethanolic extract Substances 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 229940097043 glucuronic acid Drugs 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 235000013402 health food Nutrition 0.000 description 1
- 230000000147 hypnotic effect Effects 0.000 description 1
- 230000005965 immune activity Effects 0.000 description 1
- 230000004957 immunoregulator effect Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 206010022437 insomnia Diseases 0.000 description 1
- KVKRFLVYJLIZFD-OPGZLHQPSA-N jujuboside A Natural products C[C@@H]1O[C@@H](O[C@H]2[C@H](O[C@H]3CC[C@@]4(C)[C@@H](CC[C@]5(C)[C@@H]4CC[C@@H]6[C@H]7[C@](C)(O)C[C@@H](O[C@@]78C[C@@]56CO8)C=C(C)C)C3(C)C)OC[C@H](O)[C@@H]2O[C@@H]9O[C@H](CO[C@@H]%10O[C@H](CO)[C@@H](O)[C@H](O)[C@H]%10O)[C@@H](O)[C@H](O)[C@H]9O[C@@H]%11OC[C@@H](O)[C@H](O)[C@H]%11O)[C@H](O)[C@H](O)[C@H]1O KVKRFLVYJLIZFD-OPGZLHQPSA-N 0.000 description 1
- QCLBRNPQMDEDIM-UHFFFAOYSA-N jujuboside C Natural products OC1C(O)C(O)C(C)OC1OC1C(OC2C(C(O)C(O)C(COC3C(C(O)C(O)C(CO)O3)O)O2)O)C(O)COC1OC1C(C)(C)C(CCC2(C)C34CC5(C(C(CC(O5)C=C(C)C)(C)O)C4CCC42)OC3)C4(C)CC1 QCLBRNPQMDEDIM-UHFFFAOYSA-N 0.000 description 1
- 235000020094 liqueur Nutrition 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 239000002362 mulch Substances 0.000 description 1
- 230000001662 opsonic effect Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 210000003024 peritoneal macrophage Anatomy 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000007670 refining Methods 0.000 description 1
- 230000009711 regulatory function Effects 0.000 description 1
- BJOIZNZVOZKDIG-MDEJGZGSSA-N reserpine Chemical compound O([C@H]1[C@@H]([C@H]([C@H]2C[C@@H]3C4=C([C]5C=CC(OC)=CC5=N4)CCN3C[C@H]2C1)C(=O)OC)OC)C(=O)C1=CC(OC)=C(OC)C(OC)=C1 BJOIZNZVOZKDIG-MDEJGZGSSA-N 0.000 description 1
- 229960003147 reserpine Drugs 0.000 description 1
- MDMGHDFNKNZPAU-UHFFFAOYSA-N roserpine Natural products C1C2CN3CCC(C4=CC=C(OC)C=C4N4)=C4C3CC2C(OC(C)=O)C(OC)C1OC(=O)C1=CC(OC)=C(OC)C(OC)=C1 MDMGHDFNKNZPAU-UHFFFAOYSA-N 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 230000004799 sedative–hypnotic effect Effects 0.000 description 1
- 210000000582 semen Anatomy 0.000 description 1
- 230000008667 sleep stage Effects 0.000 description 1
- 230000037322 slow-wave sleep Effects 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 229940082787 spirulina Drugs 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
- 230000005760 tumorsuppression Effects 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Mycology (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
本发明公开了一种灵芝蛹虫草颗粒，包括以下原料药：灵芝提取物350～370质量份、蛹虫草粉1400～1600质量份、茯苓提取物1400～1600质量份、酸枣仁提取物1100～1300质量份、百合提取物950～960质量份；还包括以下辅料：木糖醇1700～1900质量份、麦芽糊精1870～1890质量份。能够增强免疫力和改善睡眠，药用、保健价值高。
Description
技术领域
本发明涉及一种能增强免疫力和改善睡眠的保健食品，尤其涉及一种灵芝蛹虫草颗粒。
背景技术
现在市场上有许多增强免疫力的产品，如西洋参、维生素、蜂产品、螺旋藻等。
灵芝又称灵芝草、神芝、芝草、仙草、瑞草，是多孔菌科植物赤芝或紫芝的全株，灵芝作为拥有数千年药用历史的中国传统珍贵药材，具备很高的药用和保健价值。
现有技术中，灵芝一般都是直接食用、泡制药酒或水提取甚至精制等工艺、药品里使用等，由于缺乏有效的配制和服用手段，导致灵芝的药用、保健价值大打折扣，使其增强免疫力的效力降低，作用单一。
发明内容
本发明的目的是提供一种能增强免疫力和改善睡眠的灵芝蛹虫草颗粒，对健康具有复合功效。
本发明的目的是通过以下技术方案实现的：
本发明的灵芝蛹虫草颗粒，包括以下原料药：灵芝提取物350～370质量份、蛹虫草粉1400～1600质量份、茯苓提取物1400～1600质量份、酸枣仁提取物1100～1300质量份、百合提取物950～960质量份；
还包括以下辅料：木糖醇1700～1900质量份、麦芽糊精1870～1890质量份；
所述灵芝提取物是灵芝经过纯化水提取后，取上清液经过浓缩干燥后得到的灵芝浸膏粉，其主要成分为灵芝多糖和灵芝三帖；
所述茯苓提取物是茯苓经过纯化水提取后，取上清液经过浓缩干燥后得到的茯苓浸膏粉，其主要成分为茯苓多糖；
所述酸枣仁提取物是酸枣仁粉末经过醇提取后，取上清液经过浓缩干燥后得到的物质，其主要成分为木枣核总皂苷；
所述百合提取物是百合经过醇提取后，取上清液经过浓缩干燥后得到的物质，其主要成分为百合总皂苷。
由上述本发明提供的技术方案可以看出，本发明实施例提供的灵芝蛹虫草颗粒，由于包括以下原料药：灵芝提取物350～370质量份、蛹虫草粉1400～1600质量份、茯苓提取物1400～1600质量份、酸枣仁提取物1100～1300质量份、百合提取物950～960质量份，伴以辅料：木糖醇1700～1900质量份、麦芽糊精1870～1890质量份，制成颗粒，能够增强免疫力和改善睡眠，药用、保健价值高。
具体实施方式
下面将对本发明实施例作进一步地详细描述。
本发明的灵芝蛹虫草颗粒，其较佳的具体实施方式是：
包括以下原料药：灵芝提取物350～370质量份、蛹虫草粉1400～1600质量份、茯苓提取物1400～1600质量份、酸枣仁提取物1100～1300质量份、百合提取物950～960质量份；
还包括以下辅料：木糖醇1700～1900质量份、麦芽糊精1870～1890质量份；
所述灵芝提取物是灵芝经过纯化水提取后，取上清液经过浓缩干燥后得到的灵芝浸膏粉，其主要成分为灵芝多糖和灵芝三帖；
所述茯苓提取物是茯苓经过纯化水提取后，取上清液经过浓缩干燥后得到的茯苓浸膏粉，其主要成分为茯苓多糖；
所述酸枣仁提取物是酸枣仁粉末经过醇提取后，取上清液经过浓缩干燥后得到的物质，其主要成分为木枣核总皂苷；
所述百合提取物是百合经过醇提取后，取上清液经过浓缩干燥后得到的物质，其主要成分为百合总皂苷。
优选的，所述原料药和辅料的含量分别为：
灵芝提取物360质量份、蛹虫草粉1500质量份、茯苓提取物1500质量份、酸枣仁提取物1200质量份、百合提取物960质量份、木糖醇1800质量份、麦芽糊精1880质量份。
具体实施例：
8g/袋，共制成1000袋，1000袋原料药和辅料的用量：
原料药：灵芝提取物360g（相当于灵芝药材6kg）、蛹虫草粉1500g、茯苓提取物1500g（相当于灵芝药材10kg）、酸枣仁提取物1200g（相当于灵芝药材10kg）、百合提取物960g（相当于灵芝药材6kg）；
辅料：木糖醇1800g、麦芽糊精1880g；
推荐服用方法：每日1次，每次1袋，口服。
本发明的灵芝蛹虫草颗粒，具备以下功能：增强免疫力和改善睡眠。
本发明中的各组分经实验表明：
灵芝提取物能减少小鼠的自主活酶和过氧化氢酶的活力，加强利血平及抓丙嘛的中枢抑制，拮抗苯丙胺的中枢兴奋作用，延长戊巴比妥的睡眠时间,并增强其镇静作用。灵芝通过促进巨噬细胞吞噬作用，激活中酸性磷酶和一葡萄糖醛酸醉的活性，增强非特异性免疫的作用。灵芝多糖具有广泛的免疫调节活性,能提高机体免疫活性，大多数具有生理活性的灵芝多糖是β-D-葡聚糖。灵芝多糖提取物能提高癌症晚期病人的免疫功能。
蛹虫草[Cordyceps mditaris(L)Link]又称为北虫草、北冬虫夏草，隶属于真菌界的子囊菌门、肉座菌目、麦角菌科，是世界性广布种，我国各省区均有分布，其子座于春至秋季在半埋于林地上或腐枝落叶层下的鳞翅目昆虫蛹上长出。蛹虫草主要在免疫器官、免疫细胞及免疫分子等水平上发挥作用，增强机体的免疫功能。蛹虫草能显著提高小鼠脾、胸腺的重量和腹腔巨噬细胞数量及吞噬活性。实验表明蛹虫草ig能明显减少小鼠的自主活动,拮抗戊四氮所致的小鼠惊厥和一定程度协同戊巴比妥钠诱发小鼠睡眠,表明蛹虫草具有镇静催眠作用。蛹虫草提高红细胞天然免疫活性和免疫粘附肿瘤细胞的能力,增强免疫功能低下小鼠红细胞对自身淋巴细胞的免疫粘附调节功能。
茯苓性味甘、淡、平，功效利水渗湿，健脾补中，宁心安神。茯苓多糖具有增强免疫功能的作用,它有抗胸腺萎缩、抗脾脏增大和抑瘤生长的作用.既可增强细胞免疫,又可增强体液免疫。茯苓多糖可使免疫偏低者的LCT、Ea值有显著提高(P<0．05)，特别是能调整T细胞亚群的比值，但对IgG、IgA、IgM和等体液免疫指标均无明显影响。即茯苓多糖促进免疫作用主要是促进细胞免疫功能。
酸枣仁为鼠李科枣属植物酸枣Ziz ip hus jujuba Sp ino sa(Bunge)Hu ex H.F.Chow的干燥种子，别名枣仁、酸枣核。酸枣仁的催眠作用主要是影响慢波睡眠的深睡阶段，能明显提高小鼠淋巴细胞转化值,小鼠抗体溶血素生成也明显高于对照组,能明显增强小鼠的单核巨噬细胞的吞噬功能,可明显增加小鼠的迟发型超敏反应并能拮抗环磷酰胺引起的小鼠迟发型超敏反应的抑制。由于酸枣仁具有宁心安神的作用,治疗虚烦不眠,惊悸多梦有比较好的疗效,从而说明酸枣仁对中枢神经系统具有抑制作用。酸枣仁总皂甙也能减少小鼠自发活动,协同苯丙胺的中枢兴奋作用。其中枢抑制作用也呈剂量依赖性。药理研究表明,酸枣仁能增强免疫功能,其乙醇提取物能明显提高小鼠淋巴细胞转化值,促进抗体溶血素生成,增强单核巨噬细胞的吞噬功能，增加小鼠的体液免疫力和细胞免疫功能。酸枣仁总皂苷是酸枣仁的主要有效成分,其中主要含有酸枣仁皂苷A、B。动物实验发现:酸枣仁总皂苷能够减少小鼠自发活动,协同戊巴比妥钠的中枢抑制作用,拮抗苯丙胺的中枢兴奋作用,有阈下催眠镇静作用.
百合为常用中药,具有养阴润肺止咳、清心安神、补中益气的功效。百合能显著地增加戊巴比妥钠的睡眠时间及阂下剂量的睡眠率,县有明显的镇静作用,与中医所说的清心安神是相吻合的。给小鼠灌服百合水提液，可明显延长戊巴比妥纳睡眠时间，并使阈下量戊巴比妥纳睡眠率显著提高。百合的水溶性多糖(BHP)对小鼠免疫功能有明显的调理作用。
本发明以灵芝提取物、蛹虫草粉、茯苓提取物、酸枣仁提取物、百合提取物为原料，伴以木糖醇、麦芽糊精等辅料，制成胶囊剂，产品剂型、工艺合理，符合现代制剂要求，不但服用方便、安全可靠，而且经动物功能试验证明，能够显著增强免疫力和改善睡眠。
以上所述，仅为本发明较佳的具体实施方式，但本发明的保护范围并不局限于此，任何熟悉本技术领域的技术人员在本发明披露的技术范围内，可轻易想到的变化或替换，都应涵盖在本发明的保护范围之内。因此，本发明的保护范围应该以权利要求书的保护范围为准。
Claims (3)
1.一种灵芝蛹虫草颗粒，其特征在于，包括以下原料药：灵芝提取物350～370质量份、蛹虫草粉1400～1600质量份、茯苓提取物1400～1600质量份、酸枣仁提取物1100～1300质量份、百合提取物950～960质量份；
还包括以下辅料：木糖醇1700～1900质量份、麦芽糊精1870～1890质量份；
所述灵芝提取物是灵芝经过纯化水提取后，取上清液经过浓缩干燥后得到的灵芝浸膏粉，其主要成分为灵芝多糖和灵芝三帖；
所述茯苓提取物是茯苓经过纯化水提取后，取上清液经过浓缩干燥后得到的茯苓浸膏粉，其主要成分为茯苓多糖；
所述酸枣仁提取物是酸枣仁粉末经过醇提取后，取上清液经过浓缩干燥后得到的物质，其主要成分为木枣核总皂苷；
所述百合提取物是百合经过醇提取后，取上清液经过浓缩干燥后得到的物质，其主要成分为百合总皂苷。
2.根据权利要求1所述的灵芝蛹虫草颗粒，其特征在于，所述原料药和辅料的含量分别为：
灵芝提取物360质量份、蛹虫草粉1500质量份、茯苓提取物1500质量份、酸枣仁提取物1200质量份、百合提取物960质量份、木糖醇1800质量份、麦芽糊精1880质量份。
3.根据权利要求2所述的灵芝蛹虫草颗粒，其特征在于，所述颗粒每袋的质量为8g，每1000袋中原料药和辅料的含量分别为：
灵芝提取物360g、蛹虫草粉1500g、茯苓提取物1500g、酸枣仁提取物1200g、百合提取物960g、木糖醇1800g、麦芽糊精1880g。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310625442.0A CN103622017B (zh) | 2013-11-28 | 2013-11-28 | 灵芝蛹虫草颗粒 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310625442.0A CN103622017B (zh) | 2013-11-28 | 2013-11-28 | 灵芝蛹虫草颗粒 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103622017A true CN103622017A (zh) | 2014-03-12 |
| CN103622017B CN103622017B (zh) | 2016-04-06 |
Family
ID=50203748
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310625442.0A Active CN103622017B (zh) | 2013-11-28 | 2013-11-28 | 灵芝蛹虫草颗粒 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103622017B (zh) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106177014A (zh) * | 2016-08-26 | 2016-12-07 | 成都润馨堂药业有限公司 | 一种增强免疫力的蛹虫草颗粒及其制备方法 |
| CN108308344A (zh) * | 2018-05-04 | 2018-07-24 | 兰陵县政和菌业有限公司 | 一种宁心、益智、安神的虫草袋泡茶 |
| CN110313615A (zh) * | 2019-08-19 | 2019-10-11 | 江西仙客来生物科技有限公司 | 灵芝蛹虫草茯苓酸枣仁颗粒与制备方法 |
| CN111214555A (zh) * | 2018-11-08 | 2020-06-02 | 浙江泛亚生物医药股份有限公司 | 一种改善睡眠的中药组合物 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1626188A (zh) * | 2004-08-09 | 2005-06-15 | 刘勇成 | 一种增免安神保健品 |
| CN1660398A (zh) * | 2004-12-23 | 2005-08-31 | 杨雄志 | 一种治疗失眠的药物组合物 |
| KR20100125618A (ko) * | 2009-05-21 | 2010-12-01 | 주식회사 엔유씨전자 | 한약재 추출물이 혼합된 발효홍삼 음료의 제조방법 및 이를 포함하는 음료 조성물 |
| CN101999503A (zh) * | 2010-12-03 | 2011-04-06 | 广东省昆虫研究所 | 一种蛹虫草灵芝袋泡茶及其制作方法 |
-
2013
- 2013-11-28 CN CN201310625442.0A patent/CN103622017B/zh active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1626188A (zh) * | 2004-08-09 | 2005-06-15 | 刘勇成 | 一种增免安神保健品 |
| CN1660398A (zh) * | 2004-12-23 | 2005-08-31 | 杨雄志 | 一种治疗失眠的药物组合物 |
| KR20100125618A (ko) * | 2009-05-21 | 2010-12-01 | 주식회사 엔유씨전자 | 한약재 추출물이 혼합된 발효홍삼 음료의 제조방법 및 이를 포함하는 음료 조성물 |
| CN101999503A (zh) * | 2010-12-03 | 2011-04-06 | 广东省昆虫研究所 | 一种蛹虫草灵芝袋泡茶及其制作方法 |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106177014A (zh) * | 2016-08-26 | 2016-12-07 | 成都润馨堂药业有限公司 | 一种增强免疫力的蛹虫草颗粒及其制备方法 |
| CN108308344A (zh) * | 2018-05-04 | 2018-07-24 | 兰陵县政和菌业有限公司 | 一种宁心、益智、安神的虫草袋泡茶 |
| CN111214555A (zh) * | 2018-11-08 | 2020-06-02 | 浙江泛亚生物医药股份有限公司 | 一种改善睡眠的中药组合物 |
| CN110313615A (zh) * | 2019-08-19 | 2019-10-11 | 江西仙客来生物科技有限公司 | 灵芝蛹虫草茯苓酸枣仁颗粒与制备方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103622017B (zh) | 2016-04-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR101332321B1 (ko) | 선옥균과 한약재를 이용한 건강식품 및 그 제조방법 | |
| CN102827750A (zh) | 一种具有提高机体免疫力及性活力的玛咖保健酒 | |
| CN103622017B (zh) | 灵芝蛹虫草颗粒 | |
| CN102697035A (zh) | 虫草褔寿丹 | |
| CN102008516B (zh) | 一种治疗肿瘤的超微粉中药 | |
| CN103053733A (zh) | 一种具有益气补血、改善微循环、嫩肤养颜的东方美人茶及制备方法 | |
| CN103238702A (zh) | 多元复合灵芝茶及其制备方法 | |
| CN103877122A (zh) | 中药阿胶原料的生产方法及其产品 | |
| CN105294811A (zh) | 以林芝灵芝为原材料制备林芝三萜酸及灵芝多糖的方法 | |
| CN101104006B (zh) | 一种冬虫夏草菌提取浓缩液的制备方法及其应用 | |
| CN103829340B (zh) | 一种功能饮料及其制备方法 | |
| CN102551058A (zh) | 一种具有增强免疫力功能的中药保健品 | |
| CN109730315A (zh) | 一种抗疲劳、提高免疫力的黄精食用菌口服液及其制备方法 | |
| CN104274502B (zh) | 一种圆齿野鸦椿高效抗炎作用化合物的提取方法、产品 | |
| KR101053177B1 (ko) | 건강기능성 식품 | |
| Arora | Cordyceps sinensis (berk.) sacc.-an entomophagous medicinal fungus-a review | |
| CN105748947A (zh) | 一种铁皮石斛复方胶囊及其制备方法 | |
| CN104056054B (zh) | 一种抗氧化和增强免疫力的口服制剂及其制备 | |
| CN104906140A (zh) | 一种阿胶及其制备方法与相关设备 | |
| Jones | Reishi mushroom: Ancient medicine in modern times | |
| CN104082747A (zh) | 一种具有提高机体免疫力功能的保健食品及其制备方法 | |
| CN106074799A (zh) | 一种新会柑食用菌酵素的生产方法 | |
| CN103211224A (zh) | 一种迅速恢复男性体能复方保健食品的制备 | |
| CN103230003B (zh) | 一种具有增强免疫力功能的保健食品及其制备方法 | |
| CN106727865A (zh) | 含有蛹虫草超细粉的复合含片的制备方法 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Ganoderma lucidum and cordyceps militaris granules Effective date of registration: 20180102 Granted publication date: 20160406 Pledgee: Jiangzhou branch of Jiangxi rural commercial bank Limited by Share Ltd. Development Zone Pledgor: Pan Xinhua Registration number: 2017360000054 |
|
| TR01 | Transfer of patent right |
Effective date of registration: 20190606 Address after: 332100 Shacheng Industrial Park, Chaisang District, Jiujiang City, Jiangxi Province Patentee after: JIANGXI XIANKELAI BIOLOGICAL TECHNOLOGY Co.,Ltd. Address before: 332100 No. 221 Chaisangbei Road, Shahejie Town, Jiujiang County, Jiangxi Province Patentee before: Pan Xinhua |
|
| TR01 | Transfer of patent right | ||
| PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20231226 Granted publication date: 20160406 Pledgee: Jiangzhou branch of Jiangxi rural commercial bank Limited by Share Ltd. Development Zone Pledgor: Pan Xinhua Registration number: 2017360000054 |
|
| PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Lingzhi Pupa Cordyceps Granules Effective date of registration: 20231228 Granted publication date: 20160406 Pledgee: Jiangxi Jiangzhou Rural Commercial Bank Co.,Ltd. Shahe Sub branch Pledgor: JIANGXI XIANKELAI BIOLOGICAL TECHNOLOGY Co.,Ltd. Registration number: Y2023980075315 |
|
| PE01 | Entry into force of the registration of the contract for pledge of patent right |