CN103610847B - A kind of ointment for the treatment of radiation dermatitis and preparation method - Google Patents
A kind of ointment for the treatment of radiation dermatitis and preparation method Download PDFInfo
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Abstract
The present invention relates to a kind of ointment and preparation method for the treatment of radiation dermatitis, the raw material making described ointment effective ingredient consists of: Herba Houttuyniae, Herba Centellae, Radix Stephaniae Japonicae, Mylabris, Folium et cacumen sabinae chinensis, Herba Sophorae alopecuroidis, Radix Hamamelidis Mollis, Ramulus Euonymi (Herba Buchnerae cruciatae), Rhizoma Belamcandae, silk cotton, Radix Arnebiae (Radix Lithospermi), Radix Polygoni Multiflori, Rhizoma Polygoni Cuspidati, Nidus Vespae, Fructus Lycopersici esculenti and Folium catalpae ovatae; Selected by ointment of the present invention, medical material compatibility is suitable, meet Chinese medicine and modern medicine research theory, and adopt modern advanced medical pharmaceutical technology to make, there is effect of heat-clearing and toxic substances removing, anti-inflammatory analgetic, removing the necrotic tissue and promoting granulation, to the radiodermatitis caused due to radioactivity factor, there is significant curative effect, and long action time, safe without toxic side effect, short treating period, instant effect, can be widely used in the clinical treatment of radiodermatitis.
Description
Technical field
The present invention relates to the field of Chinese medicines, particularly a kind of ointment for the treatment of radiation dermatitis and preparation method.
Background technology
Radiodermatitis is because lonizing radiation (mainly β and gamma-rays and x-ray) irradiate the skin mucosa inflammatory injury caused.Primary disease is mainly seen in the radiocurable patient of acceptance and is engaged in radiation work and protects tight person, a series of dermoreaction and damage can be caused, show as reversible alopecia, dermatitis, pigmentation and irreversible atrophoderma, the destruction of sebaceous gland, sweat gland and permanent hair disappearance, so that radium necrosis, then forms ulcer.Cause a series of dermoreaction and damage due to these basic lesion, the impact of low dose radiation on skin is concealment and accumulation, infringement occur sooner or later and weight and radioactive character, dosage and patient individual variation relevant.
Radiodermatitis is divided into acute radiodermatitis and chronic radiodermatitis, and acute radiodermatitis causes due to the heavy dose of radiation exposure of one or many, even if but sensitive subjects dosage is not very big also can fall ill.Incubation period, because the dosage of lonizing radiation is different with each one toleration and length is indefinite, mostly is 8 ~ 20 days; Chronic radiodermatitis mostly is for a long time, repeatedly low dose of radiation exposure cause, or to be changed by acute radiodermatitis.Incubation period from the several months to many decades.Inflammation performance is not remarkable.Cause due to radiation damage sebaceous gland, sweat gland, hair follicle and nail matrix germinal layer cell xerosis cutis, coarse, chap, alopecia, there is vertical ridge, pigmentation and thickens, even coming off in first color clouding.Microcirculation of Nailfold changes, visible pipe button loop exception and capillary blood viscous.
For radiodermatitis, patient mainly strengthens supporting treatment at present, give high protein, homovitamin diet, give transfusion, Energy mixture and aminoacid etc. if desired, and vitimin supplement A, D, B, C, E etc., other available Radix Salviae Miltiorrhizae Tabellae and low molecular dextran are to improve local or systemic microcirculation, but treat comparatively slow, effect is very undesirable, Chinese medicine is the same with food is derive from the mineral of the Nature, plant, animal, there is no toxic and side effects, there is no Drug resistance, can continue to use until radical curing of disease.
Summary of the invention
The invention provides a kind of ointment and preparation method for the treatment of radiation dermatitis; Selected by ointment of the present invention, medical material compatibility is suitable, meet Chinese medicine and modern medicine research theory, and adopt modern advanced medical pharmaceutical technology to make, there is effect of heat-clearing and toxic substances removing, anti-inflammatory analgetic, removing the necrotic tissue and promoting granulation, to the radiodermatitis caused due to radioactivity factor, there is significant curative effect, and long action time, safe without toxic side effect, short treating period, instant effect, can be widely used in the clinical treatment of radiodermatitis.
Selected by ointment of the present invention, medical material compatibility is suitable, meet Chinese medicine and modern medicine research theory, and adopt modern advanced medical pharmaceutical technology to make, there is effect of heat-clearing and toxic substances removing, anti-inflammatory analgetic, removing the necrotic tissue and promoting granulation, there is significant curative effect, long action time to the radiodermatitis caused due to radioactivity factor, safe without toxic side effect, short treating period, instant effect, can be widely used in the clinical treatment of radiodermatitis.
For achieving the above object, technical scheme of the present invention is implemented as follows:
An ointment for treating radiation dermatitis, raw material composition and the parts by weight of making described ointment effective ingredient are:
Herba Houttuyniae 42-70 part Herba Centellae 42-70 part Radix Stephaniae Japonicae 42-70 part Mylabris 40-64 part
Folium et cacumen sabinae chinensis 40-64 part Herba Sophorae alopecuroidis 40-64 part Radix Hamamelidis Mollis 38-56 part Ramulus Euonymi (Herba Buchnerae cruciatae) 38-56 part
Rhizoma Belamcandae 38-56 part kapok 38-56 part Radix Arnebiae (Radix Lithospermi) 35-52 part Radix Polygoni Multiflori 35-52 part
Rhizoma Polygoni Cuspidati 35-52 part Nidus Vespae 30-48 part Fructus Lycopersici esculenti 30-48 part Folium catalpae ovatae 25-42 part.
Raw material composition and the parts by weight of making described ointment effective ingredient are:
Herba Houttuyniae 64 parts of Herba Centellaes 64 parts of Radix Stephaniae Japonicaes 64 portions of Mylabris 58 parts
Folium et cacumen sabinae chinensis 58 portions of Herba Sophorae alopecuroidiss 58 portions of Radix Hamamelidis Molliss 50 parts of Ramulus Euonymi (Herba Buchnerae cruciatae)s 50 parts
Rhizoma Belamcandae 50 portions of kapoks 50 portions of Radix Arnebiae (Radix Lithospermi)s 47 parts of Radix Polygoni Multiflori 47 parts
Rhizoma Polygoni Cuspidati 47 parts of Nidus Vespae 43 portions of Fructus Lycopersici esculenties 43 parts of Folium catalpae ovatae 37 parts.
Raw material composition and the parts by weight of making described ointment effective ingredient are:
Herba Houttuyniae 58 parts of Herba Centellaes 58 parts of Radix Stephaniae Japonicaes 58 portions of Mylabris 52 parts
Folium et cacumen sabinae chinensis 52 portions of Herba Sophorae alopecuroidiss 52 portions of Radix Hamamelidis Molliss 46 parts of Ramulus Euonymi (Herba Buchnerae cruciatae)s 46 parts
Rhizoma Belamcandae 46 portions of kapoks 46 portions of Radix Arnebiae (Radix Lithospermi)s 43 parts of Radix Polygoni Multiflori 43 parts
Rhizoma Polygoni Cuspidati 43 parts of Nidus Vespae 38 portions of Fructus Lycopersici esculenties 38 parts of Folium catalpae ovatae 33 parts.
Raw material composition and the parts by weight of making described ointment effective ingredient are:
Herba Houttuyniae 50 parts of Herba Centellaes 50 parts of Radix Stephaniae Japonicaes 50 portions of Mylabris 46 parts
Folium et cacumen sabinae chinensis 46 portions of Herba Sophorae alopecuroidiss 46 portions of Radix Hamamelidis Molliss 42 parts of Ramulus Euonymi (Herba Buchnerae cruciatae)s 42 parts
Rhizoma Belamcandae 42 portions of kapoks 42 portions of Radix Arnebiae (Radix Lithospermi)s 39 parts of Radix Polygoni Multiflori 39 parts
Rhizoma Polygoni Cuspidati 39 parts of Nidus Vespae 34 portions of Fructus Lycopersici esculenties 34 parts of Folium catalpae ovatae 29 parts.
A preparation method for the ointment for the treatment of radiation dermatitis, comprises following processing step:
(1) get Herba Houttuyniae, Herba Centellae, Radix Hamamelidis Mollis, Ramulus Euonymi (Herba Buchnerae cruciatae), Rhizoma Belamcandae, kapok, Radix Arnebiae (Radix Lithospermi), Radix Polygoni Multiflori and Folium catalpae ovatae decontamination, clean and put into container, add the distilled water of 7-9 times amount, soak after 3-4 hour, boil 2-3 hour, extract; Again add 4-6 times amount distilled water, boil 1-2 hour, extract; Finally add 2-3 times amount distilled water, heated and boiled 1-2 hour, extract; Merge three extracting solution, filtering, is the thick paste of 1.12 ~ 1.15 by relative density under filtrate simmer down to 60 DEG C of environment, for subsequent use;
(2) get Radix Stephaniae Japonicae, Folium et cacumen sabinae chinensis, Rhizoma Polygoni Cuspidati and Nidus Vespae decontamination, microwave drying, smashs to pieces, is placed in mortar and grinds into powder, crosses 200 order fine powders, for subsequent use;
(3) get Mylabris decontamination to clean, the rice adding 0.5 times amount stirs, and being fried to rice is yellowish-brown, takes out, is placed in mortar and grinds into powder, crosses 180 order fine powders, for subsequent use;
(4) get Herba Sophorae alopecuroidis decontamination, be placed in intense fire in frying pan and be fried to and smolder and till being black, taking-up cools, and is placed in mortar and grinds into powder, cross 160 order fine powders, for subsequent use;
(5) get Fructus Lycopersici esculenti to clean, smash to pieces, taking juice is for subsequent use;
(6) by thick paste, fine powder and the juice mixing obtained by above-mentioned steps (1)-(5), utilize modern advanced pharmaceutical technology, make ointment, be the ointment of described treating radiation dermatitis.
The property of medicine of the present invention's Chinese medicine used is as follows:
Herba Houttuyniae: bitter in the mouth, cold nature; Return lung, bladder, large intestine channel.Heat-clearing and toxic substances removing, eliminating carbuncle evacuation of pus, inducing diuresis for treating stranguria syndrome.Modern medicine study confirms, Herba Houttuyniae has the effect of radiation resistance and enhancing human body immunity function, and without any side effects, can improve the immunity of body, has great significance to the treatment of venereal infection.
Herba Centellae: bitter in the mouth, pungent, cold in nature; Return liver,spleen,kidney warp.Clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling.Cure mainly conjunctival congestion and swelling pain.Modern medicine study confirms, Herba Centellae water extract has the effect of anti-inflammation.
Radix Stephaniae Japonicae: sweet in the mouth, cold in nature; Attach to the lung and stomach meridians.Heat-clearing and toxic substances removing, inducing diuresis to remove edema, wind-expelling pain-stopping.For laryngopharynx swelling and pain, toothache, stomachache, edema, beriberi, urgent micturition dysurea, dysuria, vulval eczema, rheumatic arthritis; Traumatic injury is controlled in external, venom, carbuncle furuncle." Chinese herbal medicine is commonly used in Sichuan ": " diuresis, analgesic therapy are dispeled the wind.Control heart stomachache, mass in abdomen, edema, swelling due to wind, carbuncle malignant boil.”
Mylabris: acrid in the mouth, hot in nature, very toxic; Return liver, stomach, kidney channel.Removing blood stasis Xiao wei, merit poison phagedenoma, draws red foaming.Yong Yu WEIJIA lump, stubborn dermatitis for many years, scrofula, wart, carbuncle is not burst, the dead flesh of malignant boil." herbal classic ": " malignant boil cellulitis, loses dead flesh for main cold and heat, scrofula, and broken stone is infirmity.”
Folium et cacumen sabinae chinensis: acrid in the mouth, warm in nature, poisonous.Expelling wind and cold, promoting blood circulation and detoxication.Cure mainly anemofrigid cold, rheumatic arthritis, urticaria, toxic swelling from the beginning of." Fujian traditional herbal medicine ": " parasite killing dirt eliminating, powder detoxifcation.Control urticaria, scleroma toxic swelling from the beginning of.”
Herba Sophorae alopecuroidis: bitter in the mouth, cold in nature, poisonous; GUIXIN, lung meridian.Clearing away heat-damp and promoting diuresis, pain relieving parasite killing.For stomachache, trichomonas enteritis, leukorrhagia; Furuncle is controlled in external, eczema, stubborn dermatitis.Modern medicine study confirms, Herba Sophorae alopecuroidis has the effect of analgesia, antiinflammatory.
Radix Hamamelidis Mollis: sweet in the mouth, warm in nature; Enter spleen channel.Invigorating the spleen and replenishing QI.For deficiency-weakness of spleen-QI disease, impairment caused by overstrain is weak.Carry according to " Xinhua's book on Chinese herbal medicine outline ": " cure mainly impairment caused by overstrain weak." modern medicine study confirmation, Radix Hamamelidis Mollis can promote lymph blood circulation, the effect of have calmness, pacifying, and is improved effect, effectively can helps the regeneration capacity at skin night to be full of cracks, sunburn, acne.
Ramulus Euonymi (Herba Buchnerae cruciatae): bitter in the mouth, cold in nature, nontoxic.Clearing away heat and cooling blood, removing toxic substances.Cure mainly eruptive syndrome, typhoid fever, epilepsy, skin pathogenic wind toxic swells and ache." Guangxi Chinese medicinal herbal " carries: " heat-clearing and toxic substances removing, the skin pathogenic wind toxic that disappears swells and ache.”
Rhizoma Belamcandae: bitter in the mouth, cold in nature, poisonous; Return lung meridian.Heat-clearing and toxic substances removing, expectorant sore-throat relieving.For the pent-up of pyretic toxicity phlegm-fire, laryngopharynx swelling and pain, accumulation and obstruction of sputum, cough and asthma.Modern medicine study confirms, 1:10 Rhizoma Belamcandae decoct or preserved material have inhibitory action to common pathogenic dermatophytosis in test tube, and 1:20 concentration decoct also has suppression or retarding action to some virus in diseases caused by exogenous pathogenic factor and throat illness in vitro.
Kapok: acrid in the mouth, sweet, property is put down; Enter stomach, large intestine channel.Clearing away heat-damp and promoting diuresis, promoting blood circulation and detumescence.Cure mainly chronic gastritis, gastric ulcer, have loose bowels, dysentery, waist foot is unsuccessful, and lower limb knee joint pain, skin ulcer are swollen, traumatic injury etc.Modern medicine study confirms, kapok has clearing away heat and cooling blood, goes effect of stagnant removing food stagnancy, can regulate human immunity and anticancer function.
Radix Arnebiae (Radix Lithospermi): sweet in the mouth, salty, cold in nature; GUIXIN, Liver Channel.Removing heat from blood and promoting blood circulation, removing toxic substances rash.Contain for heat in blood poison, macule purple is black, measles without adequate eruption, skin infection, eczema, burn due to hot liquid or fire.Pharmacological evaluation shows, Radix Arnebiae (Radix Lithospermi) has inhibitory action to capital section 68-1 virus, also can suppress staphylococcus aureus, Bacterium prodigiosum, and the tincture of Radix Arnebiae (Radix Lithospermi) is also inhibited to pyogenic baeceria, escherichia coli.
Radix Polygoni Multiflori: sweet in the mouth, bitterness, slightly warm in nature; Return liver, kidney channel.Blood deficiency anemia, Light-headedness, cardiopalmus, insomnia, the soreness of the waist and knees of the hepatic and renal YIN deficiency, early whitening of beard and hair, tinnitus, seminal emission, dryness of the intestine constipation, chronic malaria body is empty, rubella pruritus, carbuncle sore, scrofula, hemorrhoid.Modern medicine study confirms, fibrin contained by Radix Polygoni Multiflori has lytic activity, the formation of atherosclerotic's thrombosis or microthrombus can be reduced, can directly reduce or avoid the generation of cardio cerebrovascular affection, improve, correct and prevent and treat the clinical diseases such as cerebrovas-cularaccident.
Rhizoma Polygoni Cuspidati: mildly bitter flavor, cold nature; Return liver, gallbladder, lung meridian.Heat-clearing and toxic substances removing, promoting the function of the gallbladder to alleviate jaundice, expelling wind and removing dampness, dissipating blood stasis analgesic therapy, relieving cough and resolving phlegm.For arthralgia, jaundice due to damp-heat, amenorrhea, postnatal blood stasis does not Xia ， WEIJIA, cough with copious phlegm, burn due to hot liquid or fire, traumatic injury, carbuncle sore tumefacting virus.Modern medicine study confirms, Huzhang has obvious anastalsis to traumatic hemorrhage, and for oral administration also have anastalsis to upper gastrointestinal hemorrhage, and Rhizoma Polygoni Cuspidati extract has antipyretic effect, has convergence, protects from infection and antiinflammation to scald wound.
Nidus Vespae: sweet in the mouth, property is put down; Return stomach warp.Removing the necrotic tissue and promoting granulation, anti-inflammatory analgetic, antiallergic.Be applicable to toothache due to dental caries, sore swollen toxin, acute mastitis, scrofula, skin stubborn dermatitis, fungal infection of hand and foot, allergic constitution." choosing of Simao, Yunnan Chinese herbal medicine " carries: " relaxing muscles and tendons and activating QI and blood in the collateral, method rheumatism, diuresis.Treating rheumatic arthritis, waist knee joint arthralgia chiefly caused by damp pathogen, oedema due to nephritis." modern medicine study confirmation, Nidus Vespae preparation has the effect promoting Immune Function.
Fructus Lycopersici esculenti: sour in the mouth, sweet, cold nature.Promoting the production of body fluid to quench thirst, invigorating the stomach and promoting digestion.Modern medicine study confirms, Fructus Lycopersici esculenti is rich in the multiple element such as carotene, vitamin C, vitamin B and vitamin B2 and calcium, phosphorus, potassium, magnesium, ferrum, zinc, copper and iodine, also containing protein, saccharide, organic acid, cellulose, and containing abundant antioxidant, the destruction of radical pair skin can be prevented, there is the effect that significantly beauty treatment is crease-resistant.
Folium catalpae ovatae: bitter in the mouth, cold in nature; GUIXIN, lung meridian.Heat-clearing and toxic substances removing, killing parasites for relieving itching.Cure mainly fever of children, furuncle, scabies." four tones of standard Chinese pronunciation book on Chinese herbal medicine " carries: " (decocting) washes children's's high fever, all skin ulcer scabies, skin pruritus.”
The present invention compared with prior art, has following beneficial effect:
Selected by ointment of the present invention, medical material compatibility is suitable, meet Chinese medicine and modern medicine research theory, and adopt modern advanced medical pharmaceutical technology to make, there is effect of heat-clearing and toxic substances removing, anti-inflammatory analgetic, removing the necrotic tissue and promoting granulation, to the radiodermatitis caused due to radioactivity factor, there is significant curative effect, and long action time, safe without toxic side effect, short treating period, instant effect, can be widely used in the clinical treatment of radiodermatitis.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is further elaborated.
Embodiment 1
The raw material composition of ointment effective ingredient of the present invention and weight are:
Herba Houttuyniae 68g Herba Centellae 68g Radix Stephaniae Japonicae 68g Mylabris 62g
Folium et cacumen sabinae chinensis 62g Herba Sophorae alopecuroidis 62g Radix Hamamelidis Mollis 54g Ramulus Euonymi (Herba Buchnerae cruciatae) 54g
Rhizoma Belamcandae 54g kapok 54g Radix Arnebiae (Radix Lithospermi) 51g Radix Polygoni Multiflori 51g
Rhizoma Polygoni Cuspidati 51g Nidus Vespae 47g Fructus Lycopersici esculenti 47g Folium catalpae ovatae 40g.
The preparation method of ointment of the present invention, comprises following processing step:
(1) get Herba Houttuyniae, Herba Centellae, Radix Hamamelidis Mollis, Ramulus Euonymi (Herba Buchnerae cruciatae), Rhizoma Belamcandae, kapok, Radix Arnebiae (Radix Lithospermi), Radix Polygoni Multiflori and Folium catalpae ovatae decontamination, clean and put into container, add the distilled water of 7-9 times amount, soak after 3-4 hour, boil 2-3 hour, extract; Again add 4-6 times amount distilled water, boil 1-2 hour, extract; Finally add 2-3 times amount distilled water, heated and boiled 1-2 hour, extract; Merge three extracting solution, filtering, is the thick paste of 1.12 ~ 1.15 by relative density under filtrate simmer down to 60 DEG C of environment, for subsequent use;
(2) get Radix Stephaniae Japonicae, Folium et cacumen sabinae chinensis, Rhizoma Polygoni Cuspidati and Nidus Vespae decontamination, microwave drying, smashs to pieces, is placed in mortar and grinds into powder, crosses 200 order fine powders, for subsequent use;
(3) get Mylabris decontamination to clean, the rice adding 0.5 times amount stirs, and being fried to rice is yellowish-brown, takes out, is placed in mortar and grinds into powder, crosses 180 order fine powders, for subsequent use;
(4) get Herba Sophorae alopecuroidis decontamination, be placed in intense fire in frying pan and be fried to and smolder and till being black, taking-up cools, and is placed in mortar and grinds into powder, cross 160 order fine powders, for subsequent use;
(5) get Fructus Lycopersici esculenti to clean, smash to pieces, taking juice is for subsequent use;
(6) by thick paste, fine powder and the juice mixing obtained by above-mentioned steps (1)-(5), utilize modern advanced pharmaceutical technology, make ointment, be the ointment of described treating radiation dermatitis.
Usage and dosage: external, uniform application is in affected part to absorbing completely, and every day 3 times, within 5 days, be a course for the treatment of, 2 to 3 courses for the treatment of can fully recover; The person of being in a bad way follows the doctor's advice the meal with wine amount of adding.
Embodiment 2
The raw material composition of ointment effective ingredient of the present invention and weight are:
Herba Houttuyniae 64g Herba Centellae 64g Radix Stephaniae Japonicae 64g Mylabris 58g
Folium et cacumen sabinae chinensis 58g Herba Sophorae alopecuroidis 58g Radix Hamamelidis Mollis 50g Ramulus Euonymi (Herba Buchnerae cruciatae) 50g
Rhizoma Belamcandae 50g kapok 50g Radix Arnebiae (Radix Lithospermi) 47g Radix Polygoni Multiflori 47g
Rhizoma Polygoni Cuspidati 47g Nidus Vespae 43g Fructus Lycopersici esculenti 43g Folium catalpae ovatae 37g.
The present embodiment Chinese drugs agentia preparation method processing step and usage and dosage identical with embodiment 1.
Embodiment 3
The raw material composition of ointment effective ingredient of the present invention and weight are:
Herba Houttuyniae 58g Herba Centellae 58g Radix Stephaniae Japonicae 58g Mylabris 52g
Folium et cacumen sabinae chinensis 52g Herba Sophorae alopecuroidis 52g Radix Hamamelidis Mollis 46g Ramulus Euonymi (Herba Buchnerae cruciatae) 46g
Rhizoma Belamcandae 46g kapok 46g Radix Arnebiae (Radix Lithospermi) 43g Radix Polygoni Multiflori 43g
Rhizoma Polygoni Cuspidati 43g Nidus Vespae 38g Fructus Lycopersici esculenti 38g Folium catalpae ovatae 33g.
The present embodiment Chinese drugs agentia preparation method processing step and usage and dosage identical with embodiment 1.
Embodiment 4
The raw material composition of ointment effective ingredient of the present invention and weight are:
Herba Houttuyniae 50g Herba Centellae 50g Radix Stephaniae Japonicae 50g Mylabris 46g
Folium et cacumen sabinae chinensis 46g Herba Sophorae alopecuroidis 46g Radix Hamamelidis Mollis 42g Ramulus Euonymi (Herba Buchnerae cruciatae) 42g
Rhizoma Belamcandae 42g kapok 42g Radix Arnebiae (Radix Lithospermi) 39g Radix Polygoni Multiflori 39g
Rhizoma Polygoni Cuspidati 39g Nidus Vespae 34g Fructus Lycopersici esculenti 34g Folium catalpae ovatae 29g.
The present embodiment Chinese drugs agentia preparation method processing step and usage and dosage identical with embodiment 1.
Clinical data:
1, case selection:
As the ointment for the treatment of radiation dermatitis, select radiodermatitis patient 90 example made a definite diagnosis to carry out clinical observation, patient is divided into two groups at random, treatment group 45 example, wherein man 23 example, women 22 example, age 26-60 year, 35.3 years old mean age, disease time 1-3 month; Matched group 45 example, wherein man 24 example, women 21 example, age 28-60 year, 35.8 years old mean age, course of disease 1-3 month; Two groups of patient medical record are basically identical, without significant difference, have comparability, keep on a diet all on request for two groups.
2, Therapeutic Method:
Patient for treatment group uses ointment of the present invention, external, and uniform application is in affected part to absorbing completely, and every day 3 times 5 days is a course for the treatment of, uses 2 to 3 courses for the treatment of continuously; The person of being in a bad way follows the doctor's advice the meal with wine amount of adding.
Matched group uses dexamethasone acetate ointment, by specification use, and the person of being in a bad way follows the doctor's advice the meal with wine amount of adding.
3, Outcome measure:
Cure: the transference cures such as the destruction of atrophoderma, sebaceous gland, sweat gland and permanent hair disappearance, skin function recovers normal.
Take a turn for the better: above-mentioned symptom is alleviated to some extent, and skin function recovers to some extent.
Invalid: symptom is unchanged.
4, therapeutic outcome:
Treatment group: cure 30 examples, take a turn for the better 12 examples, and invalid 3 examples, cure rate is 66.7%, and total effective rate is 93.3%.
Matched group: cure 17 examples, take a turn for the better 14 examples, and invalid 14 examples, cure rate is 37.8%, and total effective rate is 68.9%.
Above result display, the cure rate for the treatment of group and total effective rate are apparently higher than matched group.
5, model case citing:
(1) Huang, man, 36 years old, civil servant, people from Huaian, Jiangsu.Patient's cervical region suffers from malignant lymphoma, and all surrounding skins of radiotherapy many cervical regions in the future irradiation place start to occur depilation, dry, erythema, after have pain, redness progressively increases the weight of.Take multiple antibiotic medicine and external-applied ointment, poor effect.Admission examination finds that irradiation place skin has vesicle to be formed, and be radiodermatitis symptom, patient uses ointment of the present invention, and presses physician guidance diet, and keeps affected part health, takes clinical symptom disappearance after 2 courses for the treatment of, follows up a case by regular visits to, do not recur so far after half a year.
(2) beam, female, 42 years old, dining room was responsible for, people from Zaozhuang, Shandong.Patient suffers from breast cancer postoperative 2 first quarter moons, radiotherapy 40 days, and rear patient finds axillary fossa place skin swelling and pain, has a small amount of flowing water, has pain, and rear redness progressively increases the weight of, and takes cephamycin oral 6 days, poor effect in community hospital.After rear patient follows the doctor's advice and takes 3 courses for the treatment of of Chinese medicine preparation of the present invention, irradiation place skin obviously improves, and clinical symptom disappearance does not recur so far.
(3) Yao, female, 55 years old, teacher, people from Hefei ,Anhui.Patient suffers from breast carcinoma, and radiotherapy in the treatment starts after 2 weeks to occur skin of axillary fossa edematous erythema, poor effect after being coated with erythromycin ointment.Admission examination illing skin has ulceration liquid to ooze out, and rear patient uses 2 courses for the treatment of of ointment of the present invention, the irritable food such as simultaneously to give up alcohol, pungent, keep skin clean, clinical symptom disappearance, there is light pigmentation local, follow up a case by regular visits to skin color half a year and recover normal, do not recur again.
Claims (5)
1. an ointment for treating radiation dermatitis, is characterized in that: raw material composition and the parts by weight of making described ointment effective ingredient are:
Herba Houttuyniae 42-70 part Herba Centellae 42-70 part Radix Stephaniae Japonicae 42-70 part Mylabris 40-64 part
Folium et cacumen sabinae chinensis 40-64 part Herba Sophorae alopecuroidis 40-64 part Radix Hamamelidis Mollis 38-56 part Ramulus Euonymi (Herba Buchnerae cruciatae) 38-56 part
Rhizoma Belamcandae 38-56 part kapok 38-56 part Radix Arnebiae (Radix Lithospermi) 35-52 part Radix Polygoni Multiflori 35-52 part
Rhizoma Polygoni Cuspidati 35-52 part Nidus Vespae 30-48 part Fructus Lycopersici esculenti 30-48 part Folium catalpae ovatae 25-42 part.
2. the ointment of a kind for the treatment of radiation dermatitis according to claim 1, is characterized in that: raw material composition and the parts by weight of making described ointment effective ingredient are:
Herba Houttuyniae 64 parts of Herba Centellaes 64 parts of Radix Stephaniae Japonicaes 64 portions of Mylabris 58 parts
Folium et cacumen sabinae chinensis 58 portions of Herba Sophorae alopecuroidiss 58 portions of Radix Hamamelidis Molliss 50 parts of Ramulus Euonymi (Herba Buchnerae cruciatae)s 50 parts
Rhizoma Belamcandae 50 portions of kapoks 50 portions of Radix Arnebiae (Radix Lithospermi)s 47 parts of Radix Polygoni Multiflori 47 parts
Rhizoma Polygoni Cuspidati 47 parts of Nidus Vespae 43 portions of Fructus Lycopersici esculenties 43 parts of Folium catalpae ovatae 37 parts.
3. the ointment of a kind for the treatment of radiation dermatitis according to claim 1, is characterized in that: raw material composition and the parts by weight of making described ointment effective ingredient are:
Herba Houttuyniae 58 parts of Herba Centellaes 58 parts of Radix Stephaniae Japonicaes 58 portions of Mylabris 52 parts
Folium et cacumen sabinae chinensis 52 portions of Herba Sophorae alopecuroidiss 52 portions of Radix Hamamelidis Molliss 46 parts of Ramulus Euonymi (Herba Buchnerae cruciatae)s 46 parts
Rhizoma Belamcandae 46 portions of kapoks 46 portions of Radix Arnebiae (Radix Lithospermi)s 43 parts of Radix Polygoni Multiflori 43 parts
Rhizoma Polygoni Cuspidati 43 parts of Nidus Vespae 38 portions of Fructus Lycopersici esculenties 38 parts of Folium catalpae ovatae 33 parts.
4. the ointment of a kind for the treatment of radiation dermatitis according to claim 1, is characterized in that: raw material composition and the parts by weight of making described ointment effective ingredient are:
Herba Houttuyniae 50 parts of Herba Centellaes 50 parts of Radix Stephaniae Japonicaes 50 portions of Mylabris 46 parts
Folium et cacumen sabinae chinensis 46 portions of Herba Sophorae alopecuroidiss 46 portions of Radix Hamamelidis Molliss 42 parts of Ramulus Euonymi (Herba Buchnerae cruciatae)s 42 parts
Rhizoma Belamcandae 42 portions of kapoks 42 portions of Radix Arnebiae (Radix Lithospermi)s 39 parts of Radix Polygoni Multiflori 39 parts
Rhizoma Polygoni Cuspidati 39 parts of Nidus Vespae 34 portions of Fructus Lycopersici esculenties 34 parts of Folium catalpae ovatae 29 parts.
5. the preparation method of the ointment for the treatment of radiation dermatitis as described in any one of claim 1-4, is characterized in that: comprise following processing step:
(1) get Herba Houttuyniae, Herba Centellae, Radix Hamamelidis Mollis, Ramulus Euonymi (Herba Buchnerae cruciatae), Rhizoma Belamcandae, kapok, Radix Arnebiae (Radix Lithospermi), Radix Polygoni Multiflori and Folium catalpae ovatae decontamination, clean and put into container, add the distilled water of 7-9 times amount, soak after 3-4 hour, boil 2-3 hour, extract; Again add 4-6 times amount distilled water, boil 1-2 hour, extract; Finally add 2-3 times amount distilled water, heated and boiled 1-2 hour, extract; Merge three extracting solution, filtering, is the thick paste of 1.12 ~ 1.15 by relative density under filtrate simmer down to 60 DEG C of environment, for subsequent use;
(2) get Radix Stephaniae Japonicae, Folium et cacumen sabinae chinensis, Rhizoma Polygoni Cuspidati and Nidus Vespae decontamination, microwave drying, smashs to pieces, is placed in mortar and grinds into powder, crosses 200 order fine powders, for subsequent use;
(3) get Mylabris decontamination to clean, the rice adding 0.5 times amount stirs, and being fried to rice is yellowish-brown, takes out, is placed in mortar and grinds into powder, crosses 180 order fine powders, for subsequent use;
(4) get Herba Sophorae alopecuroidis decontamination, be placed in intense fire in frying pan and be fried to and smolder and till being black, taking-up cools, and is placed in mortar and grinds into powder, cross 160 order fine powders, for subsequent use;
(5) get Fructus Lycopersici esculenti to clean, smash to pieces, taking juice is for subsequent use;
(6) by thick paste, fine powder and the juice mixing obtained by above-mentioned steps (1)-(5), make ointment, be the ointment of described treating radiation dermatitis.
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| CN104491113A (en) * | 2014-12-25 | 2015-04-08 | 夏吉凯 | Traditional Chinese medicine for treating radiodermatitis |
| CN104587253A (en) * | 2015-01-23 | 2015-05-06 | 黄显玉 | Traditional Chinese medicine composition for preventing and treating radiodermatitis of head and neck and preparation method thereof |
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