CN103610048A - Health-care food with assistant protecting function to chemical liver injury and preparation method thereof - Google Patents
Health-care food with assistant protecting function to chemical liver injury and preparation method thereof Download PDFInfo
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- 206010067125 Liver injury Diseases 0.000 title abstract description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 102
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
The invention discloses a health-care food with an assistant protecting function to chemical liver injury. The health-care food comprises the following components in percentage by weight: 1-99% of a schisandra chinensis extract and 1-99% of corn peptide, totaling 100%. The preparation method comprises the following steps: mixing the weighed schisandra chinensis extract and corn peptide; prilling; tabletting to obtain the health-care food. The health-care food with the assistant protecting function to chemical liver injury disclosed by the invention avoids injury to the liver due to high concentration of alcohol and rise of enzyme content in the body through the corn peptide which accelerates alcohol metabolism and the schisandra chinensis extract which reduces the content of related enzymes in alcohol metabolism at the same time. According to the health-care food disclosed by the invention, the enzyme reducing effect of the schisandra chinensis extract and the alcohol metabolism accelerating effect of the corn pipe are synergically exerted, so that the health-care effect with the assistant protecting function to chemical liver injury is improved.
Description
Technical field
The invention belongs to health food technology field, be specifically related to a kind of health food that chemical damage is had to assistant protection function, the invention still further relates to the preparation method of this health food.
Background technology
AML (Alcoholic liver disease, ALD) is the Poisoning liver diseases causing because of long-term excessive consumption of alcohol.ALDShi American-European countries patient causes the topmost reason of cirrhosis, but growing along with the change of China's growth in the living standard, dietary structure and alcohol consumption amount, the incidence of disease of ALD also presents the trend raising year by year, has gradually caused people's attention.
On market, have more fruit of Chinese magnoliavine dissolving liver-protecting healthy food, its prescription mostly is traditional Chinese medical theory compatibility, and this series products health-care effect performance is slower, and dose is larger, and the compound product quality that more medicinal material forms is in addition wayward.The corn peptide liver-protecting product lot number occurring on market is all bread and cheese, and its composition is substantially all single corn peptide, and the mechanism of action is more single, can not embody the synergy advantage with Multiple components combination results.
Summary of the invention
The object of this invention is to provide a kind of health food that chemical damage is had to assistant protection function, the health-care effect performance that has solved existing fruit of Chinese magnoliavine dissolving liver-protecting healthy food existence is slower, the problem that dose is larger.
Another object of the present invention is to provide the preparation method of above-mentioned health food.
The technical solution adopted in the present invention is, chemical damage had to the health food of assistant protection function, composed of the following components by mass percentage: Schisandra chinens P.E 1～99%, and corn peptide 1～99%, above each constituent mass percentage sum is 100%.
Another technical scheme of the present invention is, chemical damage had to the preparation method of the health food of assistant protection function, and concrete operation step is as follows:
Step 1, takes respectively Schisandra chinens P.E 1～99% according to mass percent, corn peptide 1～99%, and above each constituent mass percentage sum is 100%;
Step 2; the Schisandra chinens P.E that step 1 is taken and corn peptide mix with starch; then add 10% starch slurry and make softwood; softwood is crossed to 16 eye mesh screens granulates; again wet granular is dried to dry particle at 40～60 ℃; finally add that talcum powder mixes and by its compressing tablet, obtain chemical damage to have the health caring food tablet of assistant protection function.
Feature of the present invention is also,
Schisandra chinens P.E manufacturing procedure comprises: Fructus Schisandrae Chinensis powder is broken to 80 orders, after adding ethanol, be heated to 60 ℃ of extractions 2～3 hours, filtration obtains schisandra chinensis ethyl hydrate extract, after extracting 2～3 times according to said extracted technique, merge schisandra chinensis ethyl hydrate extract, be heated 60 ℃ and vacuumize the recovery ethanol that refluxes, then be extracted with ethyl acetate, after the ethyl acetate in extract is reclaimed, obtain Fructus Schisandrae Chinensis extractum, finally be dried, be crushed to 80 orders, obtain Schisandra chinens P.E.
The mass ratio of ethanol and the fruit of Chinese magnoliavine is 3～5:1, and concentration of alcohol is 80%.
The volume of ethyl acetate is to reclaim 1～3 times of schisandra chinensis ethyl hydrate extract volume after ethanol.
In step 2, talcum powder quality is dry granular mass 3%.
The invention has the beneficial effects as follows, the present invention has the health food of assistant protection function to chemical damage, the mechanism of action is different from the fruit of Chinese magnoliavine and the health food of other Chinese prescriptions and the bread and cheese that simple corn peptide forms that market exists, by corn peptide, accelerate alcohol metabolism, Schisandra chinens P.E reduces the content that produces relevant enzyme in alcohol metabolism simultaneously, avoid the high concentration of alcohol in body and the damage that enzyme content raises to liver, the collaborative performance of health food of the present invention Schisandra chinens P.E falls enzyme and corn peptide promotes alcohol metabolism effect, raising has the health-care efficacy of assistant protection function to chemical damage.
The specific embodiment
Below in conjunction with the specific embodiment, the present invention is described in detail.
The present invention has the health food of assistant protection function to chemical damage, composed of the following components by mass percentage: Schisandra chinens P.E 1～99%, and corn peptide 1～99%, above each constituent mass percentage sum is 100%.
Fruit of Chinese magnoliavine Schisandra Chinensis (Turez.) Bill is famous nourishing Chinese medicine.According to Ancient Times in China herbal encyclopedia, record: the fruit of Chinese magnoliavine, fruit can be used as medicine, warm in nature, and taste acid is sweet, has the effect of astringent or styptic treatment for spontaneous sweating, the nourishing generate fluid of convergence, kidney calming.The fruit of Chinese magnoliavine is containing schizandrin A, Schisantherin C, second, third, fourth, the lignan component such as penta.Modern clinic experiment shows: Schisantherin C, ester second, ester third, ester fourth have and fall preferably SGPT effect delay property, chronic disease disposition hepatitis, the patent new drug " DDB " of China's independent research, " Wuzhi soft capsule " are for clinical treatment acute hepatitis, chronic hepatitis, and effect is remarkable.
Corn peptide is the protein extracting from wholefood corn, then the micromolecule polypeptide material that process pacemaker enzyme is cut and specific little peptide isolation technics obtains.Bibliographical information corn peptide has anti-alcohol function.Corn peptide has facilitation to alcohol metabolism, and alanine and the leucic concentration that can improve in blood produce stable NAD+, by reduce the alanine concentration discharging from muscle, reduces the concentration of alcohol in blood.The Ministry of Public Health is new resource food this product in approval on October 21st, 2010 maize oligopeptide, and from product safety aspect, corn peptide is edible raw material, and safety has no side effect.
The present invention has the health food of assistant protection function to chemical damage, the mechanism of action is different from the fruit of Chinese magnoliavine and the health food of other Chinese prescriptions and the bread and cheese that simple corn peptide forms that market exists, by corn peptide, accelerate alcohol metabolism, Schisandra chinens P.E reduces the content that produces relevant enzyme in alcohol metabolism simultaneously, avoid the high concentration of alcohol in body and the damage that enzyme content raises to liver, the collaborative performance of health food of the present invention Schisandra chinens P.E falls enzyme and corn peptide promotes alcohol metabolism effect, raising has the health-care efficacy of assistant protection function to chemical damage.
The above-mentioned preparation method who chemical damage is had to the health food of assistant protection function, concrete operation step is as follows:
Step 1, Fructus Schisandrae Chinensis powder is broken to 80 orders, adding concentration is after 80% ethanol (mass ratio of ethanol and the fruit of Chinese magnoliavine is 3～5:1), to be heated to 60 ℃ to extract 2～3 hours, filtration obtains schisandra chinensis ethyl hydrate extract, after extracting 2～3 times according to said extracted technique, merge schisandra chinensis ethyl hydrate extract, be heated 60 ℃ and vacuumize the recovery ethanol that refluxes, use again ethyl acetate (volume of ethyl acetate is to reclaim 1～3 times of schisandra chinensis ethyl hydrate extract volume after ethanol) extraction, after being reclaimed, ethyl acetate in extract obtains Fructus Schisandrae Chinensis extractum, finally be dried, be crushed to 80 orders, obtain Schisandra chinens P.E.
Step 2, takes respectively according to mass percent the Schisandra chinens P.E 1～99% that step 1 obtains, corn peptide 1～99%, and above each constituent mass percentage sum is 100%;
Step 3; the Schisandra chinens P.E that step 2 is taken and corn peptide mix with starch; then add 10% starch slurry and make softwood; softwood is crossed to 16 eye mesh screens granulates; again wet granular is dried to dry particle at 40～60 ℃; finally adding talcum powder (3% that talcum powder quality is dry granular mass) mixes and by its compressing tablet, obtains chemical damage to have the health caring food tablet of assistant protection function.
For increasing local flavor or the different dosage form manufacture craft of product, need, can suitably add corresponding auxiliary material, according to conventional preparation process, produce the product that obtains the formulations such as solid beverage, liquid beverage, capsule.
In order to study health food of the present invention, chemical damage is had to assistant protection function, carry out following experiment.
(1) experimental data
Medicine: Schisandra chinens P.E is made by oneself by pharmaceutical college of Xi'an Medical University, corn peptide is purchased from Beijing Zhong Shi Hai Shi Bioisystech Co., Ltd.Adopt preparation method of the present invention to prepare this health food, then with distilled water, dissolve, be mixed with desired concn, 4 ℃ of preservations, heating water bath to 37 ℃ before administration.
Instrument and reagent: Vital-200 automatic clinical chemistry analyzer, Dutch Wei Tu scientific instrument company product; ELx808 type ELIASA, U.S. BioTek company produces; Micro sample adding appliance, German Eppendorf company produces; YQ-3 type electric homogenate machine, Jintan City culture Instrument Ltd. product; KY91 vortex oscillator, Beijing Kai Yunyi Science and Technology Ltd. product; GL-25M high speed freezing centrifuge, Shanghai Lu Xiangyi centrifuge Co., Ltd product.Serum ALT, AST, TG detection kit are the special biotechnology of Boeing (Shanghai) Co., Ltd. product; VLDL detection kit (ELISA method), MDA, SOD kit, soudan III staining kit are Nanjing and build up Bioengineering Research Institute's product.
Animal: Kunming mouse body weight is 18～22g, male and female half and half ，You The Fourth Military Medical University animal center provides, the quality certification number: SCXK (Shan) 2007-007.
Experimental technique: 50 of kunming mices, male and female half and half, body weight 18～22g, adaptability is raised 3 days, is divided at random 5 groups.Normal group: give isometric distilled water; Model group: give isometric distilled water; Health food low dose group of the present invention: 0.105g/kg, middle dosage group: 0.21g/kg, high dose group: 0.42g/kg.Every group 10, each organizes administration volume is 10ml/kg, successive administration 28 days, and Normal group and model group give pure water.Animal is weighed weekly to twice, by body weight, adjust given the test agent amount.Model group and each sample sets gavage when experiment finishes gives 50% ethanol, mouse stomach amount 12ml/kg BW, and Normal group gives pure water, fasting 16h.Animal lumbar injection 60mg/kgBW(body weight) abdominal aorta blood sampling after amobarbital sodium solution anesthesia, and get hepatic tissue, carry out detection and the histopathologic examination of indices.
(1) press kit explanation and detect serum alt, AST, SOD, TG activity and MDA, VLDL content.
(2) dislocation of mouse cervical vertebra is got hepatic tissue after putting to death.Each group takes appropriate liver organization, adds precooling homogenate buffer (10mM Tris-HCI, 0.1mM EDTA-2Na, the 10mM sucrose of 9 times of volumes, 0.8%NaCl, pH=7.4), electronic homogenate (1500rpm, 2min), the centrifugal 15min of 3000rpm, after supernatant packing ,-80 ℃ save backup.Hydroxylamine assay is measured total SOD activity, TBA colorimetric method for determining MDA content.
Statistical analysis: experimental result with
represent, adopt one-way analysis of variance method.All experimental datas adopt SPSS13.0 software to carry out statistical procedures.Between group, significance test adopts F check.
(2) result
(1) health food of the present invention on the impact of liver function index in ethanol induced Acute hepatic injury mice serum in Table 1.
Table 1 health food of the present invention on the impact of liver function index in serum (
n=10)
*p<0.05
*p<0.01vs Normal group;
Δp<0.05
Δ Δp<0.01vs model group
As can be seen from Table 1, model group is compared serum alt, AST, TG, VLDL activity or content and is obviously raise with Normal group; The middle and high dosage group of taking health food of the present invention all can reduce serum alt, AST, TG, VLDL activity or content, and relatively there were significant differences (P<0.05 or P<0.01) with model group.
(2) health food of the present invention on the impact of SOD, MDA in ethanol induced Acute hepatic injury mouse liver tissue in Table 2.
Table 2 health food of the present invention on the impact of liver organization SOD, MDA (
n=10)
*p<0.05
*p<0.01vs Normal group;
Δp<0.05
Δ Δp<0.01vs model group
As can be known from Table 2, model group is compared total SOD activity decreased in hepatic homogenate, MDA content rising (P<0.01) with Normal group.The middle and high dosage group of taking health food of the present invention all can raise, and liver organization SOD is active, reduction MDA content, and relatively there were significant differences (P<0.05 or P<0.01) with model group.
Above experimental result shows that health food of the present invention can alleviate the mouse liver injury of alcohol induction, has assistant protection function to chemical damage.
Embodiment 1
Step 1, Fructus Schisandrae Chinensis powder is broken to 80 orders, adding concentration is after 80% ethanol (mass ratio of ethanol and the fruit of Chinese magnoliavine is 3:1), to be heated to 60 ℃ to extract 2 hours, filtration obtains schisandra chinensis ethyl hydrate extract, after extracting 3 times according to said extracted technique, merge schisandra chinensis ethyl hydrate extract, be heated 60 ℃ and vacuumize the recovery ethanol that refluxes, use again ethyl acetate (volume of ethyl acetate is to reclaim 1 times of schisandra chinensis ethyl hydrate extract volume after ethanol) extraction, after being reclaimed, ethyl acetate in extract obtains Fructus Schisandrae Chinensis extractum, finally be dried, be crushed to 80 orders, obtain Schisandra chinens P.E.
Step 2, takes respectively according to mass percent the Schisandra chinens P.E 80% that step 1 obtains, corn peptide 20%, and above each constituent mass percentage sum is 100%;
Step 3; the Schisandra chinens P.E that step 2 is taken and corn peptide mix with starch; then add 10% starch slurry and make softwood; softwood is crossed to 16 eye mesh screens granulates; again wet granular is dried to dry particle at 40 ℃; finally adding talcum powder (3% that talcum powder quality is dry granular mass) mixes and by its compressing tablet, obtains chemical damage to have the health caring food tablet of assistant protection function.
Embodiment 2
Step 1, Fructus Schisandrae Chinensis powder is broken to 80 orders, adding concentration is after 80% ethanol (mass ratio of ethanol and the fruit of Chinese magnoliavine is 5:1), to be heated to 60 ℃ to extract 3 hours, filtration obtains schisandra chinensis ethyl hydrate extract, after extracting 3 times according to said extracted technique, merge schisandra chinensis ethyl hydrate extract, be heated 60 ℃ and vacuumize the recovery ethanol that refluxes, use again ethyl acetate (volume of ethyl acetate is to reclaim 1.5 times of schisandra chinensis ethyl hydrate extract volume after ethanol) extraction, after being reclaimed, ethyl acetate in extract obtains Fructus Schisandrae Chinensis extractum, finally be dried, be crushed to 80 orders, obtain Schisandra chinens P.E.
Step 2, takes respectively according to mass percent the Schisandra chinens P.E 1% that step 1 obtains, corn peptide 99%, and above each constituent mass percentage sum is 100%;
Step 3; the Schisandra chinens P.E that step 2 is taken and corn peptide mix with starch; then add 10% starch slurry and make softwood; softwood is crossed to 16 eye mesh screens granulates; again wet granular is dried to dry particle at 45 ℃; finally adding talcum powder (3% that talcum powder quality is dry granular mass) mixes and by its compressing tablet, obtains chemical damage to have the health caring food tablet of assistant protection function.
Embodiment 3
Step 1, Fructus Schisandrae Chinensis powder is broken to 80 orders, adding concentration is after 80% ethanol (mass ratio of ethanol and the fruit of Chinese magnoliavine is 4:1), to be heated to 60 ℃ to extract 3 hours, filtration obtains schisandra chinensis ethyl hydrate extract, after extracting 2 times according to said extracted technique, merge schisandra chinensis ethyl hydrate extract, be heated 60 ℃ and vacuumize the recovery ethanol that refluxes, use again ethyl acetate (volume of ethyl acetate is to reclaim 2 times of schisandra chinensis ethyl hydrate extract volume after ethanol) extraction, after being reclaimed, ethyl acetate in extract obtains Fructus Schisandrae Chinensis extractum, finally be dried, be crushed to 80 orders, obtain Schisandra chinens P.E.
Step 2, takes respectively according to mass percent the Schisandra chinens P.E 99% that step 1 obtains, corn peptide 1%, and above each constituent mass percentage sum is 100%;
Step 3; the Schisandra chinens P.E that step 2 is taken and corn peptide mix with starch; then add 10% starch slurry and make softwood; softwood is crossed to 16 eye mesh screens granulates; again wet granular is dried to dry particle at 60 ℃; finally adding talcum powder (3% that talcum powder quality is dry granular mass) mixes and by its compressing tablet, obtains chemical damage to have the health caring food tablet of assistant protection function.
Embodiment 4
Step 1, Fructus Schisandrae Chinensis powder is broken to 80 orders, adding concentration is after 80% ethanol (mass ratio of ethanol and the fruit of Chinese magnoliavine is 4.5:1), to be heated to 60 ℃ to extract 2 hours, filtration obtains schisandra chinensis ethyl hydrate extract, after extracting 2 times according to said extracted technique, merge schisandra chinensis ethyl hydrate extract, be heated 60 ℃ and vacuumize the recovery ethanol that refluxes, use again ethyl acetate (volume of ethyl acetate is to reclaim 3 times of schisandra chinensis ethyl hydrate extract volume after ethanol) extraction, after being reclaimed, ethyl acetate in extract obtains Fructus Schisandrae Chinensis extractum, finally be dried, be crushed to 80 orders, obtain Schisandra chinens P.E.
Step 2, takes respectively according to mass percent the Schisandra chinens P.E 40% that step 1 obtains, corn peptide 60%, and above each constituent mass percentage sum is 100%;
Step 3; the Schisandra chinens P.E that step 2 is taken and corn peptide mix with starch; then add 10% starch slurry and make softwood; softwood is crossed to 16 eye mesh screens granulates; again wet granular is dried to dry particle at 50 ℃; finally adding talcum powder (3% that talcum powder quality is dry granular mass) mixes and by its compressing tablet, obtains chemical damage to have the health caring food tablet of assistant protection function.
Claims (6)
1. pair chemical damage has the health food of assistant protection function, it is characterized in that, composed of the following components by mass percentage: Schisandra chinens P.E 1～99%, and corn peptide 1～99%, above each constituent mass percentage sum is 100%.
2. the preparation method who chemical damage is had to the health food of assistant protection function according to claim 1, is characterized in that, concrete operation step is as follows:
Step 1, takes respectively Schisandra chinens P.E 1～99% according to mass percent, corn peptide 1～99%, and above each constituent mass percentage sum is 100%;
Step 2; the Schisandra chinens P.E that step 1 is taken and corn peptide mix with starch; then add 10% starch slurry and make softwood; softwood is crossed to 16 eye mesh screens granulates; again wet granular is dried to dry particle at 40～60 ℃; finally add that talcum powder mixes and by its compressing tablet, obtain chemical damage to have the health caring food tablet of assistant protection function.
3. the preparation method who chemical damage is had to the health food of assistant protection function according to claim 2, it is characterized in that, Schisandra chinens P.E manufacturing procedure comprises: Fructus Schisandrae Chinensis powder is broken to 80 orders, after adding ethanol, be heated to 60 ℃ of extractions 2～3 hours, filtration obtains schisandra chinensis ethyl hydrate extract, after extracting 2～3 times according to said extracted technique, merge schisandra chinensis ethyl hydrate extract, be heated 60 ℃ and vacuumize the recovery ethanol that refluxes, be extracted with ethyl acetate again, after being reclaimed, ethyl acetate in extract obtains Fructus Schisandrae Chinensis extractum, finally be dried, be crushed to 80 orders, obtain Schisandra chinens P.E.
4. the preparation method who chemical damage is had to the health food of assistant protection function according to claim 3, is characterized in that, the mass ratio of ethanol and the fruit of Chinese magnoliavine is 3～5:1, and concentration of alcohol is 80%.
5. the preparation method who chemical damage is had to the health food of assistant protection function according to claim 3, is characterized in that, the volume of ethyl acetate is to reclaim 1～3 times of schisandra chinensis ethyl hydrate extract volume after ethanol.
6. the preparation method who chemical damage is had to the health food of assistant protection function according to claim 2, is characterized in that, in step 2, talcum powder quality is dry granular mass 3%.
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| CN114631565A (en) * | 2022-03-28 | 2022-06-17 | 唐建 | Beverage before drinking and preparation method thereof |
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