CN103610048B - To chemical damage health food having assistant protection function and preparation method thereof - Google Patents
To chemical damage health food having assistant protection function and preparation method thereof Download PDFInfo
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- CN103610048B CN103610048B CN201310598431.8A CN201310598431A CN103610048B CN 103610048 B CN103610048 B CN 103610048B CN 201310598431 A CN201310598431 A CN 201310598431A CN 103610048 B CN103610048 B CN 103610048B
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Mycology (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
The invention discloses a kind of health food chemical damage being had to assistant protection function, composed of the following components by mass percentage: Schisandra chinens P.E 1 ~ 99%, corn peptide 1 ~ 99%, above each constituent mass percentage sum is 100%.Its preparation method be the Schisandra chinens P.E taken and corn peptide mixed with starch, granulate, compressing tablet obtains.The present invention has the health food of assistant protection function to chemical damage; alcohol metabolism is accelerated by corn peptide; Schisandra chinens P.E reduces the content producing relevant enzyme in alcohol metabolism simultaneously; avoid high concentration and the damage of enzyme content rising to liver of alcohol in body; enzyme and the effect of corn peptide promotion alcohol metabolism fall in the collaborative Schisandra chinens P.E that plays of health food of the present invention, improve health-care efficacy chemical damage being had to assistant protection function.
Description
Technical field
The invention belongs to technical field of health care food, be specifically related to a kind of health food chemical damage being had to assistant protection function, the invention still further relates to the preparation method of this health food.
Background technology
AML (Alcoholicliverdisease, ALD) is the Poisoning liver diseases because long-term excessive consumption of alcohol causes.ALD is the topmost reason that American-European countries patient causes cirrhosis, but along with the change of China's growth in the living standard, dietary structure and the growing of alcohol consumption amount, the incidence of disease of ALD also presents the trend raised year by year, gradually causes the attention of people.
Market has more fruit of Chinese magnoliavine dissolving liver-protecting healthy food, its prescription mostly is traditional Chinese medical theory compatibility, and the performance of this series products health-care effect is comparatively slow, and dose is comparatively large, and the compound product quality of more medicinal material composition is wayward in addition.The corn peptide liver-protecting product lot number that market occurs is all bread and cheese, and its composition is substantially all single corn peptide, and the mechanism of action is more single, can not embody the synergy advantage combining with Multiple components and produce.
Summary of the invention
The object of this invention is to provide a kind of health food chemical damage being had to assistant protection function, the health-care effect performance solving the existence of existing fruit of Chinese magnoliavine dissolving liver-protecting healthy food is comparatively slow, the problem that dose is larger.
Another object of the present invention is to provide the preparation method of above-mentioned health food.
The technical solution adopted in the present invention is, chemical damage is had to the health food of assistant protection function, composed of the following components by mass percentage: Schisandra chinens P.E 1 ~ 99%, corn peptide 1 ~ 99%, and above each constituent mass percentage sum is 100%.
Another technical scheme of the present invention is that chemical damage is had to the preparation method of the health food of assistant protection function, concrete operation step is as follows:
Step 1, takes Schisandra chinens P.E 1 ~ 99% respectively according to mass percent, corn peptide 1 ~ 99%, and above each constituent mass percentage sum is 100%;
Step 2; Schisandra chinens P.E step 1 taken and corn peptide mix with starch; then add 10% starch slurry and make softwood; softwood is crossed 16 eye mesh screens to granulate; again wet granular is dried to dry particle at 40 ~ 60 DEG C; finally add talcum powder mixing and by its compressing tablet, namely obtain health caring food tablet chemical damage being had to assistant protection function.
Feature of the present invention is also,
Schisandra chinens P.E manufacturing procedure comprises: Fructus Schisandrae Chinensis powder is broken to 80 orders, be heated to 60 DEG C after adding ethanol to extract 2 ~ 3 hours, filtration obtains schisandra chinensis ethyl hydrate extract, schisandra chinensis ethyl hydrate extract is merged after extracting 2 ~ 3 times according to said extracted technique, be heated 60 DEG C and vacuumize backflow recovery ethanol, then be extracted with ethyl acetate, after being reclaimed by the ethyl acetate in extract, obtain Fructus Schisandrae Chinensis extractum, finally be dried, be crushed to 80 orders, obtain Schisandra chinens P.E.
The mass ratio of ethanol and the fruit of Chinese magnoliavine is 3 ~ 5:1, and concentration of alcohol is 80%.
The volume of ethyl acetate is 1 ~ 3 times of schisandra chinensis ethyl hydrate extract volume after recovery ethanol.
In step 2, talcum powder quality is 3% of dry granular mass.
The invention has the beneficial effects as follows, the present invention has the health food of assistant protection function to chemical damage, the mechanism of action is different from the bread and cheese that the fruit of Chinese magnoliavine of market existence forms with the health food of other Chinese prescriptions and simple corn peptide, alcohol metabolism is accelerated by corn peptide, Schisandra chinens P.E reduces the content producing relevant enzyme in alcohol metabolism simultaneously, avoid high concentration and the damage of enzyme content rising to liver of alcohol in body, enzyme and the effect of corn peptide promotion alcohol metabolism fall in the collaborative Schisandra chinens P.E that plays of health food of the present invention, improve health-care efficacy chemical damage being had to assistant protection function.
Detailed description of the invention
Below in conjunction with detailed description of the invention, the present invention is described in detail.
The present invention has the health food of assistant protection function to chemical damage, composed of the following components by mass percentage: Schisandra chinens P.E 1 ~ 99%, corn peptide 1 ~ 99%, and above each constituent mass percentage sum is 100%.
Fruit of Chinese magnoliavine SchisandraChinensis (Turez.) Bill is famous nourishing Chinese medicine.Record according to Ancient Times in China herbal encyclopedia: the fruit of Chinese magnoliavine, fruit can be used as medicine, warm in nature, and taste acid is sweet, has effect of astringent or styptic treatment for spontaneous sweating, the nourishing generate fluid of convergence, kidney calming.The fruit of Chinese magnoliavine containing schizandrin A, Schisantherin C, second, third, fourth, the lignan component such as penta.Modern clinic experiment shows: Schisantherin C, ester second, ester third, ester fourth have unresolved, chronic disease disposition hepatitis falls SGPT effect preferably, the patent new drug " DDB " of China's independent research, " Wuzhi soft capsule " for clinical treatment acute hepatitis, chronic hepatitis, Be very effective.
Corn peptide is the protein extracted from wholefood corn, then through the micromolecule polypeptide material that pacemaker enzyme is cut and specific little peptide isolation technics obtains.Bibliographical information corn peptide has anti-alcohol function.Corn peptide has facilitation to alcohol metabolism, can improve alanine in blood and leucic concentration produces stable NAD+, by reducing the alanine concentration discharged from muscle, reduces the concentration of alcohol in blood.The Ministry of Public Health is new resource food this product in approval on October 21st, 2010 maize oligopeptide, and from product safety aspect, corn peptide is edible raw material, and safety has no side effect.
The present invention has the health food of assistant protection function to chemical damage, the mechanism of action is different from the bread and cheese that the fruit of Chinese magnoliavine of market existence forms with the health food of other Chinese prescriptions and simple corn peptide, alcohol metabolism is accelerated by corn peptide, Schisandra chinens P.E reduces the content producing relevant enzyme in alcohol metabolism simultaneously, avoid high concentration and the damage of enzyme content rising to liver of alcohol in body, enzyme and the effect of corn peptide promotion alcohol metabolism fall in the collaborative Schisandra chinens P.E that plays of health food of the present invention, improve health-care efficacy chemical damage being had to assistant protection function.
Above-mentioned preparation method chemical damage being had to the health food of assistant protection function, concrete operation step is as follows:
Step 1, Fructus Schisandrae Chinensis powder is broken to 80 orders, adding concentration is be heated to 60 DEG C after the ethanol (mass ratio of ethanol and the fruit of Chinese magnoliavine is 3 ~ 5:1) of 80% to extract 2 ~ 3 hours, filtration obtains schisandra chinensis ethyl hydrate extract, schisandra chinensis ethyl hydrate extract is merged after extracting 2 ~ 3 times according to said extracted technique, be heated 60 DEG C and vacuumize backflow recovery ethanol, ethyl acetate (volume of ethyl acetate is 1 ~ 3 times of schisandra chinensis ethyl hydrate extract volume after reclaiming ethanol) is used to extract again, Fructus Schisandrae Chinensis extractum is obtained after being reclaimed by ethyl acetate in extract, finally be dried, be crushed to 80 orders, obtain Schisandra chinens P.E.
Step 2, take according to mass percent the Schisandra chinens P.E 1 ~ 99% that step 1 obtains respectively, corn peptide 1 ~ 99%, above each constituent mass percentage sum is 100%;
Step 3; Schisandra chinens P.E step 2 taken and corn peptide mix with starch; then add 10% starch slurry and make softwood; softwood is crossed 16 eye mesh screens to granulate; again wet granular is dried to dry particle at 40 ~ 60 DEG C; finally add talcum powder (talcum powder quality is 3% of dry granular mass) mixing and by its compressing tablet, namely obtain health caring food tablet chemical damage being had to assistant protection function.
For the local flavor or different dosage form manufacture craft that increase product need, can suitably add corresponding auxiliary material, preparation process conveniently produces the product obtaining the formulations such as solid beverage, liquid beverage, capsule.
There is assistant protection function in order to study health food of the present invention to chemical damage, carrying out following experiment.
(1) experimental data
Medicine: Schisandra chinens P.E is made by oneself by pharmaceutical college of Xi'an Medical University, and corn peptide is purchased from Beijing Zhongshi Haishi Biotechnology Co., Ltd..Adopt preparation method of the present invention to prepare this health food, then dissolve with distilled water, be mixed with desired concn, 4 DEG C of preservations, heating water bath to 37 DEG C before administration.
Instrument and reagent: Vital-200 automatic clinical chemistry analyzer, Dutch Wei Tu Scientific Instruments Corporation product; ELx808 type ELIASA, BioTek company of the U.S. produces; Micro sample adding appliance, German Eppendorf company produces; YQ-3 type electric homogenate machine, culture Instrument Ltd. of Jintan City product; KY91 vortex oscillator, Beijing Kai Yunyi Science and Technology Ltd. product; GL-25M high speed freezing centrifuge, Shanghai Lu Xiangyi centrifuge Co., Ltd product.Serum ALT, AST, TG detection kit are Boeing special biotechnology (Shanghai) Co., Ltd. product; VLDL detection kit (ELISA method), MDA, SOD kit, soudan III staining kit are Nanjing and build up Bioengineering Research Institute's product.
Animal: Kunming mouse body weight is 18 ~ 22g, male and female half and half are provided by The Fourth Military Medical University's animal center, the quality certification number: SCXK (Shan) 2007-007.
Experimental technique: kunming mice 50, male and female half and half, body weight 18 ~ 22g, adaptability raises 3 days, is divided into 5 groups at random.Normal group: give isometric distilled water; Model group: give isometric distilled water; Health food low dose group of the present invention: 0.105g/kg, middle dosage group: 0.21g/kg, high dose group: 0.42g/kg.Often organize 10, each group administration volume is 10ml/kg, and successive administration 28 days, Normal group and model group give pure water.Animal is weighed weekly twice, by body weight adjustment given the test agent amount.Model group and each sample group gavage at the end of experiment gives the ethanol of 50%, and mouse stomach amount 12ml/kgBW, Normal group gives pure water, fasting 16h.Animal lumbar injection 60mg/kgBW(body weight) Nembutal sodium solution anesthesia after abdominal aorta blood sampling, and get hepatic tissue, carry out detection and the histopathologic examination of indices.
(1) by kit, detection serum alt, AST, SOD, TG activity and MDA, VLDL content are described.
(2) mouse cervical dislocation gets hepatic tissue after putting to death.Each group takes appropriate liver organization, add the precooling homogenate buffer (10mMTris-HCI of 9 times of volumes, 0.1mMEDTA-2Na, 10mM sucrose, 0.8%NaCl, pH=7.4), electronic homogenate (1500rpm, 2min), the centrifugal 15min of 3000rpm, after supernatant packing ,-80 DEG C save backup.Hydroxylamine assay measures total SOD activity, TBA colorimetric method for determining MDA content.
Statistical analysis: experimental result with
represent, adopt one-way analysis of variance method.All experimental datas adopt SPSS13.0 software to carry out statistical procedures.Between group, significance test adopts F inspection.
(2) result
(1) health food of the present invention on the impact of liver function index in ethanol induced Acute hepatic injury mice serum in table 1.
Table 1 health food of the present invention on the impact of liver function index in serum (
n=10)
*p<0.05
*p<0.01vs Normal group;
Δp<0.05
Δ Δp<0.01vs model group
As can be seen from Table 1, model group serum alt, AST, TG, VLDL activity or content compared with Normal group obviously raises; The middle and high dosage group taking health food of the present invention all can reduce the active or content of serum alt, AST, TG, VLDL, compares that there were significant differences (P<0.05 or P<0.01) with model group.
(2) health food of the present invention on the impact of SOD, MDA in ethanol induced Acute hepatic injury mouse liver tissue in table 2.
Table 2 health food of the present invention on the impact of liver organization SOD, MDA (
n=10)
*p<0.05
*p<0.01vs Normal group;
Δp<0.05
Δ Δp<0.01vs model group
As can be known from Table 2, model group is total SOD activity reduction in hepatic homogenate compared with Normal group, and MDA content raises (P<0.01).The middle and high dosage group taking health food of the present invention all can raise liver organization SOD active, reduce MDA content, compare with model group that there were significant differences (P<0.05 or P<0.01).
Above experimental result shows that health food of the present invention can alleviate the mouse liver injury of alcohol induction, has assistant protection function to chemical damage.
Embodiment 1
Step 1, Fructus Schisandrae Chinensis powder is broken to 80 orders, adding concentration is be heated to 60 DEG C after the ethanol (mass ratio of ethanol and the fruit of Chinese magnoliavine is 3:1) of 80% to extract 2 hours, filtration obtains schisandra chinensis ethyl hydrate extract, schisandra chinensis ethyl hydrate extract is merged after extracting 3 times according to said extracted technique, be heated 60 DEG C and vacuumize backflow recovery ethanol, ethyl acetate (volume of ethyl acetate is 1 times of schisandra chinensis ethyl hydrate extract volume after reclaiming ethanol) is used to extract again, Fructus Schisandrae Chinensis extractum is obtained after being reclaimed by ethyl acetate in extract, finally be dried, be crushed to 80 orders, obtain Schisandra chinens P.E.
Step 2, take according to mass percent the Schisandra chinens P.E 80% that step 1 obtains respectively, corn peptide 20%, above each constituent mass percentage sum is 100%;
Step 3; Schisandra chinens P.E step 2 taken and corn peptide mix with starch; then add 10% starch slurry and make softwood; softwood is crossed 16 eye mesh screens to granulate; again wet granular is dried to dry particle at 40 DEG C; finally add talcum powder (talcum powder quality is 3% of dry granular mass) mixing and by its compressing tablet, namely obtain health caring food tablet chemical damage being had to assistant protection function.
Embodiment 2
Step 1, Fructus Schisandrae Chinensis powder is broken to 80 orders, adding concentration is be heated to 60 DEG C after the ethanol (mass ratio of ethanol and the fruit of Chinese magnoliavine is 5:1) of 80% to extract 3 hours, filtration obtains schisandra chinensis ethyl hydrate extract, schisandra chinensis ethyl hydrate extract is merged after extracting 3 times according to said extracted technique, be heated 60 DEG C and vacuumize backflow recovery ethanol, ethyl acetate (volume of ethyl acetate is 1.5 times of schisandra chinensis ethyl hydrate extract volume after reclaiming ethanol) is used to extract again, Fructus Schisandrae Chinensis extractum is obtained after being reclaimed by ethyl acetate in extract, finally be dried, be crushed to 80 orders, obtain Schisandra chinens P.E.
Step 2, take according to mass percent the Schisandra chinens P.E 1% that step 1 obtains respectively, corn peptide 99%, above each constituent mass percentage sum is 100%;
Step 3; Schisandra chinens P.E step 2 taken and corn peptide mix with starch; then add 10% starch slurry and make softwood; softwood is crossed 16 eye mesh screens to granulate; again wet granular is dried to dry particle at 45 DEG C; finally add talcum powder (talcum powder quality is 3% of dry granular mass) mixing and by its compressing tablet, namely obtain health caring food tablet chemical damage being had to assistant protection function.
Embodiment 3
Step 1, Fructus Schisandrae Chinensis powder is broken to 80 orders, adding concentration is be heated to 60 DEG C after the ethanol (mass ratio of ethanol and the fruit of Chinese magnoliavine is 4:1) of 80% to extract 3 hours, filtration obtains schisandra chinensis ethyl hydrate extract, schisandra chinensis ethyl hydrate extract is merged after extracting 2 times according to said extracted technique, be heated 60 DEG C and vacuumize backflow recovery ethanol, ethyl acetate (volume of ethyl acetate is 2 times of schisandra chinensis ethyl hydrate extract volume after reclaiming ethanol) is used to extract again, Fructus Schisandrae Chinensis extractum is obtained after being reclaimed by ethyl acetate in extract, finally be dried, be crushed to 80 orders, obtain Schisandra chinens P.E.
Step 2, take according to mass percent the Schisandra chinens P.E 99% that step 1 obtains respectively, corn peptide 1%, above each constituent mass percentage sum is 100%;
Step 3; Schisandra chinens P.E step 2 taken and corn peptide mix with starch; then add 10% starch slurry and make softwood; softwood is crossed 16 eye mesh screens to granulate; again wet granular is dried to dry particle at 60 DEG C; finally add talcum powder (talcum powder quality is 3% of dry granular mass) mixing and by its compressing tablet, namely obtain health caring food tablet chemical damage being had to assistant protection function.
Embodiment 4
Step 1, Fructus Schisandrae Chinensis powder is broken to 80 orders, adding concentration is be heated to 60 DEG C after the ethanol (mass ratio of ethanol and the fruit of Chinese magnoliavine is 4.5:1) of 80% to extract 2 hours, filtration obtains schisandra chinensis ethyl hydrate extract, schisandra chinensis ethyl hydrate extract is merged after extracting 2 times according to said extracted technique, be heated 60 DEG C and vacuumize backflow recovery ethanol, ethyl acetate (volume of ethyl acetate is 3 times of schisandra chinensis ethyl hydrate extract volume after reclaiming ethanol) is used to extract again, Fructus Schisandrae Chinensis extractum is obtained after being reclaimed by ethyl acetate in extract, finally be dried, be crushed to 80 orders, obtain Schisandra chinens P.E.
Step 2, take according to mass percent the Schisandra chinens P.E 40% that step 1 obtains respectively, corn peptide 60%, above each constituent mass percentage sum is 100%;
Step 3; Schisandra chinens P.E step 2 taken and corn peptide mix with starch; then add 10% starch slurry and make softwood; softwood is crossed 16 eye mesh screens to granulate; again wet granular is dried to dry particle at 50 DEG C; finally add talcum powder (talcum powder quality is 3% of dry granular mass) mixing and by its compressing tablet, namely obtain health caring food tablet chemical damage being had to assistant protection function.
Claims (4)
1. chemical damage is had to the preparation method of the health food of assistant protection function, it is characterized in that, concrete operation step is as follows:
Step 1, takes Schisandra chinens P.E 1 ~ 99% respectively according to mass percent, corn peptide 1 ~ 99%, and above each constituent mass percentage sum is 100%;
Step 2, Schisandra chinens P.E step 1 taken and corn peptide mix with starch, then add 10% starch slurry and make softwood, softwood is crossed 16 eye mesh screens to granulate, again wet granular is dried to dry particle at 40 ~ 60 DEG C, finally add talcum powder mixing and by its compressing tablet, namely obtain health caring food tablet chemical damage being had to assistant protection function;
Schisandra chinens P.E manufacturing procedure comprises: Fructus Schisandrae Chinensis powder is broken to 80 orders, be heated to 60 DEG C after adding ethanol to extract 2 ~ 3 hours, filtration obtains schisandra chinensis ethyl hydrate extract, schisandra chinensis ethyl hydrate extract is merged after extracting 2 ~ 3 times according to said extracted technique, be heated 60 DEG C and vacuumize backflow recovery ethanol, then be extracted with ethyl acetate, after being reclaimed by the ethyl acetate in extract, obtain Fructus Schisandrae Chinensis extractum, finally be dried, be crushed to 80 orders, obtain Schisandra chinens P.E.
2. preparation method chemical damage being had to the health food of assistant protection function according to claim 1, is characterized in that, the mass ratio of ethanol and the fruit of Chinese magnoliavine is 3 ~ 5:1, and concentration of alcohol is 80%.
3. preparation method chemical damage being had to the health food of assistant protection function according to claim 1, is characterized in that, the volume of ethyl acetate is 1 ~ 3 times of schisandra chinensis ethyl hydrate extract volume after recovery ethanol.
4. preparation method chemical damage being had to the health food of assistant protection function according to claim 1, is characterized in that, in step 2, talcum powder quality is 3% of dry granular mass.
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| CN101513464A (en) * | 2009-03-27 | 2009-08-26 | 武汉大学 | Medicament for relieving alcoholism and protecting liver and preparation method thereof |
| CN102018952A (en) * | 2010-12-20 | 2011-04-20 | 付斌 | Tablet for nourishing liver, protecting liver, sobering up and strengthening kidney and preparation process thereof |
| CN102106580A (en) * | 2011-02-23 | 2011-06-29 | 福建康之味食品工业有限公司 | Sobering-up and liver-protecting health beverage |
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| CN101513464A (en) * | 2009-03-27 | 2009-08-26 | 武汉大学 | Medicament for relieving alcoholism and protecting liver and preparation method thereof |
| CN102018952A (en) * | 2010-12-20 | 2011-04-20 | 付斌 | Tablet for nourishing liver, protecting liver, sobering up and strengthening kidney and preparation process thereof |
| CN102106580A (en) * | 2011-02-23 | 2011-06-29 | 福建康之味食品工业有限公司 | Sobering-up and liver-protecting health beverage |
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