CN103599508A

CN103599508A - Traditional Chinese medicine composition for treating pediatric uremia

Info

Publication number: CN103599508A
Application number: CN201310582458.8A
Authority: CN
Inventors: 徐洪海; 徐峰
Original assignee: ANHUI BAOZHITANG PHARMACEUTICAL Co Ltd
Current assignee: ANHUI BAOZHITANG PHARMACEUTICAL Co Ltd
Priority date: 2013-11-19
Filing date: 2013-11-19
Publication date: 2014-02-26
Anticipated expiration: 2033-11-19
Also published as: CN103599508B

Abstract

The invention relates to a traditional Chinese medicine composition for treating pediatric uremia. The traditional Chinese medicine composition consists of oral administration medicine and external application medicine, wherein the oral administration medicine is prepared from the following raw pharmaceutical materials in weight: 9g of inula flower, 9g of ginger, 9g of prepared pinellia tuber, 6g of prepared liquorice roots, 4 Chinese dates, 9g of codonopsis pilosula, 30g of black aconite accessory tuber, 9g of rhubarb, 3g of asarum, 15g of codonopsis pilosula, 10g of magnolia bark, 10g o f fructus evodiae, 20g of dried tangerine peel, 20g of tuckahoe, 20g of hooked uncaria, 20g of tribulus terrestris, 20g of nacre, 20g of oyster, 10g of gentian, 10g of gardenia, 10g of coptis root, 10g of grass-leaved sweet flag rhizome, 10g of radix curcumae, 10g of tabasheer and 20g of keel; the external application medicine is prepared from the following raw pharmaceutical materials in weight: 15g of reddle, 9g of gastrodia tuber, 9g of gardenia, 9g of scutellaria root, 9g of eucommia bark, 9g of herba leonuri, 9g of mistletoe, 9g of tuber fleece flower stem, 9g of red poria with hostwood, 12g of radix cyathulae, 12g of hooked uncaria, 5g of antelope powder, 10g of Dadian, 12g of rhizoma alismatis, 9g of akebia stem, 9g of plantain seeds, 10g of rush, 10g of artemisia annua, 8g of wax gourd peels, 10g of talc and 9g of cortex dictamni. The traditional Chinese medicine composition has the characteristics of easiness in material obtaining, simplicity in preparation, low cost, reasonable compatibility and the like, is small in dosage, low in content of harmful ingredients and remarkable in curative effect, and is free from toxic and side effects.

Description

A kind of uremic Chinese medicine composition of children's that is used for the treatment of

Technical field

The present invention relates to field of Chinese herbal medicine technology, be specifically related to the uremic Chinese medicine composition of a kind of children's of being used for the treatment of.

Background technology

Uremia is the disease of poor prognosis, due to long-term nephropathy, and chronic nephritis especially, with the passing of time edema, move the court of a feudal ruler repeatedly, kidney qi exhaustion, noxious water retention; Or after swollen moving back, weakened body resistance not multiple, cause deficiency of spleen-YANG and kidneyYANG or the liver-fire deficiency of YIN, with the passing of time again can excess caused by deficiency.Burnt in the yang deficiency evil strongly fragrant resistance that water is wet, upward gush of turbid YIN is violated stomach, even hoodwinks the mind; Strongly fragrant and the heat-transformation of the evil malicious turbid damp of the deficiency of YIN, liver-yang is partially high, the raw expectorant wind symptom of fire-transformation, and in causing, close thinking, conscience, with sick, can cause the absurd row of forcing blood.Severe patient often shows coldheat complex, and spleen, kidney, the heart, liver are with sick.Due to the domination of pathogen and weakened body resistance influencing each other, the state of an illness is constantly worsened, to weakened body resistance, can not win heresy eventually, finally there is unconsciousness and collapse, there is the moon to exhaust the danger time that sun is died.

Summary of the invention

Technical problem to be solved by this invention is to provide a kind of cure rate high, the safe and reliable uremic Chinese medicine composition of children's that is used for the treatment of.

Technical problem to be solved by this invention realizes by the following technical solutions:

Be used for the treatment of the uremic Chinese medicine composition of children's, oral medicine and external application, will consist of, wherein oral medicine is comprised of the component of following weight,

9 grams of Flos Inulae (bag), 9 grams, Rhizoma Zingiberis Recens, 9 grams of Rhizoma Pinelliae Preparata, 6 grams of Radix Glycyrrhizae Preparatas, 4 pieces, Fructus Jujubae, 9 grams of Radix Codonopsis, RADIX ACONITI LATERALIS PREPARATA 30 grams of (boiled water is decocted first 1 hour), 9 grams of Radix Et Rhizoma Rhei, 3 grams of Herba Asaris, 15 grams of Radix Codonopsis, 10 grams of Cortex Magnoliae Officinalis, 10 grams of Fructus Evodiae, 20 grams of Pericarpium Citri Reticulataes, 20 grams, Poria, 20 grams of Ramulus Uncariae Cum Uncis, 20 grams of Fructus Atriplicis Sibiricaees, 20 grams of Concha Margaritiferas, 20 grams of Concha Ostreaes, 10 grams of Radix Gentianaes, 10 grams of Fructus Gardeniae, 10 grams of Rhizoma Coptidis, 10 grams of Rhizoma Acori Graminei, 10 grams of Radix Curcumaes, 10 grams of Concretio Silicea Bambusaes, 20 grams of Os Draconis.

Wherein application compress are comprised of the component of following weight,

15 grams of Haematitums, 9 grams, Rhizoma Gastrodiae, 9 grams of Fructus Gardeniaes, 9 grams of Radix Scutellariaes, 9 grams of the Cortexs Eucommiae, 9 grams of Herba Leonuris, 9 grams of Herba Taxillis, 9 grams of Caulis Polygoni Multiflori, 9 grams of Porias, 12 grams of Radix Cyathulaes, 12 grams of Ramulus Uncariae Cum Uncis, 5 grams of cornu saigae tatariace powders, 10 grams of grand ceremonies, 12 grams of Rhizoma Alismatis, 9 grams of Caulis Akebiaes, 9 grams of Semen Plantaginiss, 10 grams of Medulla Juncies, 10 grams of Herba Artemisiae Annuaes, 8 grams of Exocarpium Benincasaes, 10 grams, Talcum, 9 grams of Cortex Dictamnis.

Described oral medicine makes decoction according to conventional decoction, every day potion, sooner or later sub-service.

Described application compress are that each component is ground into end altogether, cross after 130 mesh sieve, refine into cream, stick on big vertebra, Pishu, Zhangmen, shen shu, Qihai, tsu san li, Taixi acupuncture point, remove after fixing 8 hours outward with preservative film, once a day, be for seven times a course for the treatment of, clinical practice shows, general 1 course for the treatment of is effective, 2-3 the course for the treatment of is evident in efficacy, and for treatment, uremia opens up a new way.

The present invention's crude drug used can be bought and obtain from common Chinese shop, and its specification meets national Chinese crude drug standard.

The mechanism of Fang Zhongyong rhubarb treatment kidney merit exhaustion:

1. Profilin is decomposed, and improves amino acid metabolism.

2. suppress mesangial cell proliferation, its functional shift of corresponding inhibition.

3. resist the effect of its somatomedin.

4. suppress renal tubular function metabolism.It is turbid that we are with Radix Et Rhizoma Rhei that main purging FU-organs is let out, and observes the variation of urinating rope nitrogen, creatinine in feces and blood before and after treatment, confirm Radix Et Rhizoma Rhei have from intestinal remove nitrogen matter function and.

Medicated diet prepared by the present invention has carried out a large amount of clinical trials of a large amount of animal acute toxicity tests, long-term toxicity test for animals and treatment disease, and the use link that this medicine is dropped into treatment disease provides science and objective foundation.Its test method and result of the test are as follows respectively:

1. the medicated diet that couple the present invention boils carries out animal acute toxicity test:

Medicine: the decoction being boiled by prescription of the present invention, saving backup ，You The First Affiliated Hospital of Anhui College of Traditional Chinese Medicine in refrigerator provides.

Experimental animal: white mice, body weight is at 30-50g, and male and female select ，You Medical University Of Anhui to provide at random.

Method and result: get 50 of white mice, be divided into 5 groups, 10 every group, hungry about 15 hours, by every each 5ml, fill with medicine feed thing, in 24 hours, fill with respectively medicine feed thing 1,2,3,4,5 times, observe 5 days for the 1st, 2,3,4,5 groups, white mice is movable normal, and non-toxic reaction, without dead.Wherein white mice dosage is calculated by kg body weight dose, shows that oral liquid is without acute toxicity, clinical medicine dose safety.

2. the decoction that couple the present invention boils carries out long-term toxicity test for animals:

Experimental animal: rat, body weight, at 120-130g, all selects male white rat ，You Medical University Of Anhui to provide.

Method and result: get 50 of rat, be divided into 5 groups, every group 10, wherein the 1st, 2, 3, 4 groups as administration group, fill with respectively medicine feed thing 4ml for every group, 6ml, 8ml, 10ml, the 5th group of normal feeding as a control group, once a day, continuous irrigation is fed 90 days, survey body weight, 24 hours sacrificed by decapitation after last administration, survey blood, routine urinalysis, liver function, renal function, core, the internal organs such as kidney, the variation of tissues observed form, observe the effect of dosage, observe diet, movable variation, experimental results show that administration group and matched group are relatively without significant change, the visible kg body weight of pressing is calculated the equal non-toxic reaction of dosage doubly with respect to clinical 50-200, a kind of safe drugs.

3. in order to verify clinical efficacy, this prescription Jieshou City institute of traditional Chinese medicine tries out, by choosing at random wherein cavernous pulmonary tuberculosis 40 examples;

1) Therapeutic Method

According to drug ratios of the present invention, take raw material (dosage), according to the method for conventionally boiling medicine, obtain medicinal liquid for oral administration, every day, potion, serviced once sooner or later; Application compress are refined into high, stick on big vertebra, Pishu, Zhangmen, shen shu, Qihai, tsu san li, Taixi acupuncture point, within 7 days, are a course for the treatment of.

2) clinical data

This is organized in 40 examples, male 26 examples, female's 14 examples, age 2-14 year.

3) therapeutic outcome

Effective 30 examples: refer to that endogenous creatinine clearance rate, blood urea nitrogen, uric acid, interior creatinine index all reach in normal range and urine protein is turned out cloudy.

Effective 8 examples: These parameters has one or some to take a favorable turn.

Invalid 2 examples: one of These parameters is not improved or reverses.

The invention has the beneficial effects as follows: the present invention draws materials easily, makes the features such as simple, with low cost, compatibility is reasonable, and taking dose is little, and Harmful ingredient content is low, has no side effect, evident in efficacy.

The specific embodiment

For technological means, creation characteristic that the present invention is realized, reach object and effect is easy to understand, below in conjunction with specific embodiment, further set forth the present invention.

Embodiment 1

Described application compress are that each component is ground into end altogether, cross after 130 mesh sieve, refine into cream, stick on big vertebra, Pishu, Zhangmen, shen shu, Qihai, tsu san li, Taixi acupuncture point, remove after fixing 8 hours outward with preservative film, once a day, it is for seven times a course for the treatment of, clinical practice shows, general 1 course for the treatment of is effective, and 2-3 the course for the treatment of is evident in efficacy.

Model case

Case 1

Still so-and-so, man, 6.Because of uncomfortable in chest, breathe hard, feel sick, vomiting, weak to city examination in hospital renal function Cr727.7umol/l, BUN27.7mmol/l, HB75g/L, urine protein +++, B ultrasonic shows two renal atrophys, hospital diagnosis is uremia, hemodialysis, household disagrees with dialysis.After in carrying out here diagnosis, the clear saliva of patients ' vomiting, has urine stink in mouthful, uncomfortable in chest, abdominal distention, lack of appetite is dizzy, body is tired drowsiness, fear of cold, complexion is gloomy, oliguria or close, pale tongue is fat, tongue is greasy in vain, soft and thready pulse, and tcm diagnosis belongs to upward gush of turbid YIN card (turbid damp obstructing in middle-JIAO, stomach-QI being unable to descend normally).Control should warming YANG let out turbid, lowering the adverse QI to ease the middleJIAO.With treating with prescription drug of the present invention, oral administration and externally used, continuous use 1 week, symptom alleviates, and after 4 weeks, disease is cured, and recovers as before.

Case 2

Cui so-and-so, female, 8 people from Linquan County of Sui， Anhui Province.Medical on 09 20th, 2012.Dizzy headache, dizzy, brothers are moving, twitch, and god is wrong manic, nausea and vomiting, dry lip, epistaxis, tooth Mus, yellow fur or burned black and dry, body of the tongue red drop, stringy and thready pulse.Urine protein +++, B ultrasonic shows two renal atrophys, is diagnosed as uremia, tcm diagnosis belongs to wind sun phlegm syndrome (disturb on liver-yang, close in phlegm-fire), controlling should suppressing the hyperactive liver to relieve the wind syndrome, clearing away fire and eliminating phlegm.With treating with prescription drug of the present invention, oral administration and externally used, continuous use 1 week, symptom alleviates, and after 4 weeks, symptom all disappears, and patient recovers as before.

Case 3

So-and-so people from Taihe County of ，Nan ，12Sui， Anhui Province ends.Medical on 06 16th, 2011.Obnubilation, pale complexion, the limbs with coldness, shallow breathing, hyperhidrosis, enuresis and encopresis, pale tongue, faint and thready pulse.Urine protein +++, B ultrasonic shows two renal atrophys, is diagnosed as uremia.Tcm diagnosis belongs to syndrome of depletion of yin causing yang collapse (unconsciousness and collapse, negative and positive all exhaust), controls suitable QI invigorating yin fluid astringing, recuperating the depleted YANG to cure collapse-syndrome as emergency treatment.With treating with prescription drug of the present invention, oral administration and externally used, continuous use 1 week, symptom alleviates, and after 4 weeks, symptom all disappears, and patient recovers as before.

More than show and described ultimate principle of the present invention and principal character and advantage of the present invention.The technical staff of the industry should understand; the present invention is not restricted to the described embodiments; that in above-described embodiment and description, describes just illustrates principle of the present invention; without departing from the spirit and scope of the present invention; the present invention also has various changes and modifications, and these changes and improvements all fall in the claimed scope of the invention.The claimed scope of the present invention is defined by appending claims and equivalent thereof.

Claims

1. be used for the treatment of the uremic Chinese medicine composition of children's, by oral medicine and external application, will be formed, it is characterized in that: wherein oral medicine is comprised of the component of following weight,

9 grams of Flos Inulae, 9 grams, Rhizoma Zingiberis Recens, 9 grams of Rhizoma Pinelliae Preparata, 6 grams of Radix Glycyrrhizae Preparatas, 4 pieces, Fructus Jujubae, 9 grams of Radix Codonopsis, 30 grams of RADIX ACONITI LATERALIS PREPARATA, 9 grams of Radix Et Rhizoma Rhei, 3 grams of Herba Asaris, 15 grams of Radix Codonopsis, 10 grams of Cortex Magnoliae Officinalis, 10 grams of Fructus Evodiae, 20 grams of Pericarpium Citri Reticulataes, 20 grams, Poria, 20 grams of Ramulus Uncariae Cum Uncis, 20 grams of Fructus Atriplicis Sibiricaees, 20 grams of Concha Margaritiferas, 20 grams of Concha Ostreaes, 10 grams of Radix Gentianaes, 10 grams of Fructus Gardeniae, 10 grams of Rhizoma Coptidis, 10 grams of Rhizoma Acori Graminei, 10 grams of Radix Curcumaes, 10 grams of Concretio Silicea Bambusaes, 20 grams of Os Draconis;

2. a kind of uremic Chinese medicine composition of children's that is used for the treatment of according to claim 1, it is characterized in that: described application compress are that each component is ground into end altogether, cross after 130 mesh sieve, refine into cream, stick on big vertebra, Pishu, Zhangmen, shen shu, Qihai, tsu san li, Taixi acupuncture point, after fixing 8 hours outward with preservative film, removing, once a day, is for seven times a course for the treatment of.

3. the purposes of a kind of Chinese medicine composition according to claim 1 in treatment children's uremia.