CN100455310C - Ointment preparation for treating urinaemia - Google Patents
Ointment preparation for treating urinaemia Download PDFInfo
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- CN100455310C CN100455310C CNB2006100172535A CN200610017253A CN100455310C CN 100455310 C CN100455310 C CN 100455310C CN B2006100172535 A CNB2006100172535 A CN B2006100172535A CN 200610017253 A CN200610017253 A CN 200610017253A CN 100455310 C CN100455310 C CN 100455310C
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Abstract
A Chinese medicine in the form of unguent for treating uremia is prepared from 20 Chinese-medicinal materials including rhubarb, honeysuckle flower, capejasmine fruit, China root, etc.
Description
Technical field
The present invention discloses the uremic ointment formulation of a kind of treatment, is used for the treatment of uraemia, belongs to traditional Chinese medical science pharmaceutical technology field.
Background technology
Uremia is the general name of a series of symptoms of being taken place late period of renal failure.The chronic renal failure symptom is presented as that mainly poisoning that harmful substance accumulation causes and kidney hormone reduce the anemia that takes place and close osteopathia.Early stage modal be to feel sick, vomit symptom of digestive tract such as loss of appetite.Enter late stage uremia after the stage, the whole body system all can get involved, and serious situation such as heart failure, psychological problem, stupor occurs, threat to life.
Have his own strong points in Chinese medicine, doctor trained in Western medicine aspect the uremic treatment, but western medical treatment adopts Drug therapys such as hormones, therapeutic effect is limited, side effect is very big but not satisfactory, the state of an illness repeatedly, can only index can not effect a permanent cure, the patient suffering can produce many complication for a long time; Diseases such as the method treatment uremia of dialysis, renal failure cause internal organs atrophy gradually, depletion such as kidney for a long time; Finally will transplant kidney, and survival period also is limited, kidney transplantation has factor affecting such as rejection in addition.
Traditional Chinese medical science heat clearing away often, detoxify, dispel silt, nourishing YIN and invigorating YANG etc. are means.The advantage of this therapy is a non-relapse after healing, and shortcoming is the bad grasp of the medical skill of this therapy, and utilization gets up to be difficult to suit the medicine to the illness, so cure rate is low, the treatment phase is long.
Summary of the invention
The present invention discloses the uremic ointment formulation of a kind of treatment, it is characterized in that being made by following raw medicaments in portion by weight:
Radix Et Rhizoma Rhei 1000-3000g, Flos Lonicerae 4000-7000g, Fructus Forsythiae 4000-7000g,
Cortex Phellodendri 1000-3000g, Fructus Gardeniae 1000-3000g, Rhizoma Smilacis Glabrae 7000-12000g,
Indigo Naturalis 1500-2000g, Radix Salviae Miltiorrhizae 2000-4000g, Flos Carthami 500-1000g,
Radix Sanguisorbae 4000-7000g, Fructus Tribuli 1000-3000g, Ramulus Uncariae Cum Uncis 4000-7000g,
Flos Sophorae Immaturus 10000-14000g;
Above-mentioned ointment formulation is also by following crude drug:
Os Draconis (calcined) 4000-7000g, Concha Ostreae (calcined) 4000-7000g, Radix Ginseng 1000-3000g, Fructus Lycii 1000-3000g, Radix Ophiopogonis 600-1200g, Ramulus Cinnamomi 1000-3000g,
Rhizoma Imperatae 1000-3000g.
Best proportioning of the present invention is:
Radix Et Rhizoma Rhei 2000g, Flos Lonicerae 6000g, Fructus Forsythiae 6000g, Cortex Phellodendri 2000g, Fructus Gardeniae 2000g, Rhizoma Smilacis Glabrae 10000g, Indigo Naturalis 1800g, Radix Salviae Miltiorrhizae 3000g, Flos Carthami 700g, Radix Sanguisorbae 6000g, Fructus Tribuli 2000g, Ramulus Uncariae Cum Uncis 6000g, Flos Sophorae Immaturus 12000g, Os Draconis (calcined) 6000g, Concha Ostreae (calcined) 6000g, Radix Ginseng 1000g, Fructus Lycii 2000g, Radix Ophiopogonis 1000g, Ramulus Cinnamomi 2000g, Rhizoma Imperatae 2000g.
The processing procedure of described ointment formulation is as follows: above 20 flavors, and Os Draconis, Concha Ostreae is given as one thinks fit cataclasm, adds 8 times of water gagings and is decocted first 4 hours, filters, and filtrate and medicinal residues are standby.Radix Salviae Miltiorrhizae is with 85% alcohol reflux secondary, and each 1.5 hours, alcohol adding amount was 8 times, merge extractive liquid,, and extracting solution and medicinal residues are standby.Fructus Forsythiae, Rhizoma Smilacis Glabrae, Radix Sanguisorbae, Fructus Tribuli, the Flos Sophorae Immaturus, Ramulus Cinnamomi, Rhizoma Imperatae, Radix Ophiopogonis eight, flavor decocted with water three times with Os Draconis, Concha Ostreae, Radix Salviae Miltiorrhizae decoction dregs, decocting time was respectively 2,2,1 hours, amount of water is 8 times, collecting decoction, filter, filtrate and Os Draconis, Concha Ostreae decocting liquid merge, and are condensed into thick paste (1.35～1.45,55 ℃ of surveys).Radix Et Rhizoma Rhei, Flos Lonicerae, Cortex Phellodendri, Fructus Gardeniae, Flos Carthami, Ramulus Uncariae Cum Uncis, Radix Ginseng, Fructus Lycii eight flavors are with 85% ethanol extraction secondary, and extraction time was respectively 2,1 hours, and alcohol adding amount is 10,8 times.Merge extractive liquid, merges with the Radix Salviae Miltiorrhizae ethanol extract, reclaims ethanol, is condensed into thick paste (1.35～1.45,55 ℃ of surveys).Above-mentioned two thick pastes merge, and add the Indigo Naturalis powder, mixing, and drying is ground into impalpable powder, fully stirs with ointment base (5000g), mixing, fill is made 1000, promptly.
Specification: adorn 15 grams for every
Function cures mainly:
Purging FU-organs is let out turbid, inducing diuresis to remove edema.Be used for anasarca, nausea and vomiting, constipation, anuria oliguria, headache is fidgety, yellowish fur on the tongue, greasy fur, forceful pulse is strong, and renal failure, azotemia and renal hypertension.
Usage and dosage
This product is an externally-applied soft ointment.Rectally, one time one, 1～2 time on the 1st, use sooner or later or after an action of the bowels.Puncture the mouth of pipe with the tip that covers during use, put the head of keeping a public place clean of outfit, insert the anal administration.7 days is a course of treatment, can logotype 2 courses of treatment.
Be monarch drug with the Radix Et Rhizoma Rhei in prescription of the present invention, this product has the merit of intestinal stasis relieving, pathogenic fire purging, removing blood stasis, dehumidifying, the gastrointestinal of leading to rapidly, ascending the clear and descending the turbid.Minister concentrates the auxiliary monarch drug of the efficacy of a drug to strengthen the smooth three warmers of a surname with Flos Lonicerae, Fructus Forsythiae, Cortex Phellodendri, Fructus Gardeniae, Rhizoma Smilacis Glabrae, Indigo Naturalis, Radix Salviae Miltiorrhizae, Flos Carthami, Radix Sanguisorbae, the Flos Sophorae Immaturus (that heat-clearing and toxic substances removing, damp eliminating are let out is turbid, blood circulation promoting and blood stasis dispelling, cooling blood for hemostasis, dredge its QI and blood), mediates the drug effect of turbid pyretic toxicity.Assistant is helped the principal drug assistance treating both the principal and secondary aspects of a disease with Fructus Atriplicis Sibiricae, Os Draconis, Concha Ostreae, Radix Ginseng, Fructus Lycii, Radix Ophiopogonis (nourishing YIN for attracting YANG, suppressing the hyperactive liver to relieve the wind syndrome, invigorating primordial QI, Xuanhua yang-energy, protect Tianjin protect liquid, the beneficial blood of enriching blood), helps rehabilitation.Make with the through sick institute of Rhizoma Imperatae (arrogate to oneself and walk lower orifices, diuresis) Ke's priming.All medicines share, and play clearing away heat-damp and promoting diuresis altogether, blood circulation promoting and blood stasis dispelling, and regulate yin-yang, and society removes the effect of setting upright.
For showing the curative effect of medicine of the present invention, now clinical test results is reported as follows:
One, Western medicine diagnose standard
Draft according to the standard in " new Chinese medicine clinical guidance principle ".
1, often be secondary to peripheral circulatory failure or nephrotoxicity due to the various serious diseases after, but also have indivedual cases can not have tangible protopathy;
2, take place hurriedly oliguria (＜400ml/24h), but also have non-oliguria type person can not have oliguria performance, in indivedual serious cases (cortical necrosis of kidney) but anuria (＜100ml/24h);
3, hurried generation and the azotemia that grows with each passing day;
4, after a few days～several weeks, as handle appropriately, diuresis stage can occur;
5, routine urianlysis: urine is and waits (proportion 1.010～1.016), albuminuria (often be +～++), Urine sediments analyzer often has granular cast, epithelial cell fragment, erythrocyte and leukocyte;
6, before establishing diagnosis, must get rid of the acute renal failure that sexual factor causes behind property before the kidney or the kidney.
Two, Chinese medical discrimination standard
Draft according to the related standards in " new Chinese medicine clinical guidance principle ".
(1), syndrome of accumulated dampness-heat
Primary symptom: the oliguria urine retention, nausea and vomiting, urine is smelly in mouthful.
Inferior disease: heating, xerostomia be fidgety, the mind situation of desire drink, headache, tic, yellowish fur, slippery and rapid pulse.All primary symptoms have 2, or have time disease person concurrently and can make a definite diagnosis.
One, pathogenesis and rule of treatment analysis
Obstruction and rejection, grand close, the syndrome of accumulated dampness-heat of edema, lumbago, the kidney-wind syndrome etc. is one of common card of tcm clinical practice, " card control converge mend " said: " obstruction and rejection person ... both closed and lattice must urinary obstruction, between morning and evening; increase vomiting and nausea on foot; this is because of the turbid pathogen three warmers that are jammed, and healthy energy must not lifting, so about down and anuria; lattice are in last and give birth to tell and vomit; negative and positive are closed exhausted, and one promptly dead, the most the danger time ".Clinical often have oliguria urine retention, nausea and vomiting, mouthful in performances such as smelly, the headache and dizzy of urine, agitation, yellowish fur, slippery and rapid pulse, Chinese medical discrimination belongs to damp and hot heap soil or fertilizer over and around the roots knot syndrome, and theory of Chinese medical science thinks, this disease many because of in grandly close, late period of diseases such as edema, stranguria, spleen kidney yin sun is feeble and exhausted, due to accumulateing in the turbid pathogen.The clinical card that follows often shows as deficiency in origin and excess in superficiality, coldheat complex.In the weakened body resistance pathogenesis of primary disease, often exist the objective variation of the domination of pathogen, the domination of pathogen has the different of damp and hot and cold-damp.During treatment when knowing the secondary from the primary and the medication of the side of choosing, but because of turbid pathogen all the time in whole disease progression process, and turbid damp lives for a long time, often easily causes damp-heat accumulation, thus ought note constantly eliminating evil, the rule of treatment of promptly so-called " control main, as to control the visitor when suddenly " when slow.Modern medicine thinks that renal function nonfunction pathologic basis is that mainly going down of kidney urinary function causes gathering of interior metabolism product, the Water-Electrolyte disorder.This research is at the pathogenesis and the clinical characters thereof of its " the turbid pathogen three warmers that are jammed, healthy energy must not lifting ", and it " is controlled mainly when slow, control the visitor when anxious according to " Standards of Diagnosis and Treatment obstruction and rejection " in the treatment." the rule of treatment, let out turbidly with purging FU-organs, the inducing diuresis to remove edema method by prescriptions such as Radix Et Rhizoma Rhei, Flos Lonicerae, the Flos Sophorae Immaturus, is made uremic spirit ointment through modern crafts, is used for the treatment of the renal failure syndrome of accumulated dampness-heat.
Two, efficacy analysis
The comparative study of renal failure syndrome of accumulated dampness-heat patient 160 routine clinical random packet being tested by uremic spirit ointment and uremic spirit enema shows:
(1), uremic spirit Ointment in Treatment renal failure syndrome of accumulated dampness-heat determined curative effect.
1, uremic spirit ointment is to symptom, the sign effect of having clear improvement of renal failure syndrome of accumulated dampness-heat, to oliguria urine retention, nausea and vomiting, mouthful in symptom and signs such as smelly, the headache and dizzy of urine, agitation, yellowish fur, slippery and rapid pulse, the improvement effect of significance is arranged, to renal failure syndrome of accumulated dampness-heat tcm syndrome curative effect is cure-remarkable-effectiveness rate 63.33%, effective percentage 30.00%, total effective rate 93.33%, and significantly diuresis is arranged.
2, the curative effect of uremic spirit ointment and the course of disease length of renal failure syndrome of accumulated dampness-heat do not have dependency relation, but its curative effect and its state of an illness weight have tangible dependency relation, the light good effect of the state of an illness, and the heavy curative effect of the state of an illness is relatively poor.
Observation group's 60 examples, the comprehensive therapeutic effect of treatment renal failure syndrome of accumulated dampness-heat is: clinic control 9 examples (15.00%), produce effects 21 examples (35.00%), effective 22 examples (36.67%), total effective rate is 86.67%, to renal failure syndrome of accumulated dampness-heat tcm syndrome curative effect is: clinical recovery 11 examples (18.33%), produce effects 27 examples (45.00%), effective 18 examples (30.00%), total effective rate 93.33%.
Matched group 60 examples, the comprehensive therapeutic effect of treatment renal failure syndrome of accumulated dampness-heat is: clinic control 10 examples (16.67%), produce effects 20 examples (33.33%), effective 20 examples (33.33%), total effective rate 83.33%.To renal failure syndrome of accumulated dampness-heat tcm syndrome curative effect be: clinical recovery 13 examples (21.67%), produce effects 23 examples (38.33%), effective 19 examples (31.67%), total effective rate 91.67%.
Open observation group 40 examples, the comprehensive therapeutic effect of treatment renal failure syndrome of accumulated dampness-heat is: clinic control 1 example (2.50%), produce effects 6 examples (15.00%), effective 28 examples (7.00%), total effective rate 87.50%.To renal failure syndrome of accumulated dampness-heat tcm syndrome curative effect be: clinical recovery 12 examples (30.00%), produce effects 19 examples (47.50%), effective 8 examples (20.00%), total effective rate 97.50%.
The specific embodiment
The following example is intended to further describe for example the present invention, rather than limits the present invention by any way.Under the prerequisite that does not deviate from the spirit and principles in the present invention, any change or change that those of ordinary skills that the present invention did are realized easily all will fall within the claim scope of the present invention.
Embodiment 1
Take by weighing following raw material: Radix Et Rhizoma Rhei 1000g, Flos Lonicerae 4500g, Fructus Forsythiae 5000g, Cortex Phellodendri 2000g, Fructus Gardeniae 2000g, Rhizoma Smilacis Glabrae 11000g, Indigo Naturalis 1800g, Radix Salviae Miltiorrhizae 2500g, Flos Carthami 700g, Radix Sanguisorbae 5500g, Fructus Tribuli 2500g, Ramulus Uncariae Cum Uncis 6000g, Flos Sophorae Immaturus 12000g.
Concoct above 13 flavors, add 8 times of water gagings and be decocted first 4 hours, filter, filtrate and medicinal residues are standby.Radix Salviae Miltiorrhizae is with 85% alcohol reflux secondary, and each 1.5 hours, alcohol adding amount was 8 times, merge extractive liquid,, and extracting solution and medicinal residues are standby.Fructus Forsythiae, Rhizoma Smilacis Glabrae, Radix Sanguisorbae, Fructus Tribuli, the Flos Sophorae Immaturus decoct with water three times, and decocting time was respectively 2,2,1 hours, and amount of water is 8 times, and collecting decoction filters, and is condensed into thick paste (1.35～1.45,55 ℃ of surveys).Radix Et Rhizoma Rhei, Flos Lonicerae, Cortex Phellodendri, Fructus Gardeniae, Flos Carthami, Ramulus Uncariae Cum Uncis etc. are with 85% ethanol extraction secondary, and extraction time was respectively 2,1 hours, and alcohol adding amount is 10,8 times.Merge extractive liquid, merges with the Radix Salviae Miltiorrhizae ethanol extract, reclaims ethanol, is condensed into thick paste (1.35～1.45,55 ℃ of surveys).Above-mentioned two thick pastes merge, and add the Indigo Naturalis powder, mixing, and drying is ground into impalpable powder, fully stirs with ointment base (5000g), mixing, fill is made 1000, promptly.
Embodiment 2
Get Radix Et Rhizoma Rhei 1500g, Flos Lonicerae 5500g, Fructus Forsythiae 7000g, Cortex Phellodendri 3000g, Fructus Gardeniae 2000g, Rhizoma Smilacis Glabrae 12000g, Indigo Naturalis 1850g, Radix Salviae Miltiorrhizae 2500g, Flos Carthami 900g, Radix Sanguisorbae 6000g, Fructus Tribuli 2000g, Ramulus Uncariae Cum Uncis 5500g, Flos Sophorae Immaturus 12000g, Os Draconis (forging) 6000g, Concha Ostreae (forging) 6000g, Radix Ginseng 1000g, Fructus Lycii 2000g, Radix Ophiopogonis 1000g, Ramulus Cinnamomi 2000g, Rhizoma Imperatae 2500g;
With Os Draconis, Concha Ostreae is given as one thinks fit cataclasm, adds 8 times of water gagings and is decocted first 4 hours, filters, and filtrate and medicinal residues are standby; Radix Salviae Miltiorrhizae is with 85% alcohol reflux secondary, and each 1.5 hours, alcohol adding amount was 8 times, merge extractive liquid,, and extracting solution and medicinal residues are standby; Fructus Forsythiae, Rhizoma Smilacis Glabrae, Radix Sanguisorbae, Fructus Tribuli, the Flos Sophorae Immaturus, Ramulus Cinnamomi, Rhizoma Imperatae, Radix Ophiopogonis eight, flavor decocted with water three times with Os Draconis, Concha Ostreae, Radix Salviae Miltiorrhizae decoction dregs, decocting time was respectively 2,2,1 hours, amount of water is 8 times, collecting decoction, filter, filtrate and Os Draconis, Concha Ostreae decocting liquid merge, and are condensed into thick paste; Radix Et Rhizoma Rhei, Flos Lonicerae, Cortex Phellodendri, Fructus Gardeniae, Flos Carthami, Ramulus Uncariae Cum Uncis, Radix Ginseng, Fructus Lycii eight flavors are with 85% ethanol extraction secondary, and extraction time was respectively 2,1 hours, and alcohol adding amount is 10,8 times; Merge extractive liquid, merges with the Radix Salviae Miltiorrhizae ethanol extract, reclaims ethanol, is condensed into thick paste; Above-mentioned two thick pastes merge, and add the Indigo Naturalis powder, mixing, and drying is ground into impalpable powder, with ointment base; Fully stir, mixing, fill, promptly.
Embodiment 3
Radix Et Rhizoma Rhei 2000g, Flos Lonicerae 6000g, Fructus Forsythiae 6000g, Cortex Phellodendri 2000g, Fructus Gardeniae 2000g, Rhizoma Smilacis Glabrae 10000g, Indigo Naturalis 1800g, Radix Salviae Miltiorrhizae 3000g, Flos Carthami 700g, Radix Sanguisorbae 6000g, Fructus Tribuli 2000g, Ramulus Uncariae Cum Uncis 6000g, Flos Sophorae Immaturus 12000g, Os Draconis (calcined) 6000g, Concha Ostreae (calcined) 6000g, Radix Ginseng 1000g, Fructus Lycii 2000g, Radix Ophiopogonis 1000g, Ramulus Cinnamomi 2000g, Rhizoma Imperatae 2000g.
With Os Draconis, Concha Ostreae is given as one thinks fit cataclasm, adds 8 times of water gagings and is decocted first 4 hours, filters, and filtrate and medicinal residues are standby; Radix Salviae Miltiorrhizae is with 85% alcohol reflux secondary, and each 1.5 hours, alcohol adding amount was 8 times, merge extractive liquid,, and extracting solution and medicinal residues are standby; Fructus Forsythiae, Rhizoma Smilacis Glabrae, Radix Sanguisorbae, Fructus Tribuli, the Flos Sophorae Immaturus, Ramulus Cinnamomi, Rhizoma Imperatae, Radix Ophiopogonis eight, flavor decocted with water three times with Os Draconis, Concha Ostreae, Radix Salviae Miltiorrhizae decoction dregs, decocting time was respectively 2,2,1 hours, amount of water is 8 times, collecting decoction, filter, filtrate and Os Draconis, Concha Ostreae decocting liquid merge, and are condensed into thick paste; Radix Et Rhizoma Rhei, Flos Lonicerae, Cortex Phellodendri, Fructus Gardeniae, Flos Carthami, Ramulus Uncariae Cum Uncis, Radix Ginseng, Fructus Lycii eight flavors are with 85% ethanol extraction secondary, and extraction time was respectively 2,1 hours, and alcohol adding amount is 10,8 times; Merge extractive liquid, merges with the Radix Salviae Miltiorrhizae ethanol extract, reclaims ethanol, is condensed into thick paste; Above-mentioned two thick pastes merge, and add the Indigo Naturalis powder, mixing, and drying is ground into impalpable powder, with ointment base; Fully stir, mixing, fill, promptly.
Claims (3)
1, the uremic ointment formulation of a kind of treatment is characterized in that being made by following raw medicaments in portion by weight:
Radix Et Rhizoma Rhei 1000-3000g, Flos Lonicerae 4000-7000g, Fructus Forsythiae 4000-7000g,
Cortex Phellodendri 1000-3000g, Fructus Gardeniae 1000-3000g, Rhizoma Smilacis Glabrae 7000-12000g,
Indigo Naturalis 1500-2000g, Radix Salviae Miltiorrhizae 2000-4000g, Flos Carthami 500-1000g,
Radix Sanguisorbae 4000-7000g, Fructus Tribuli 1000-3000g, Ramulus Uncariae Cum Uncis 4000-7000g,
Flos Sophorae Immaturus 10000-14000g, Os Draconis (calcined) 4000-7000g, Concha Ostreae (calcined) 4000-7000g,
Radix Ginseng 1000-3000g, Fructus Lycii 1000-3000g, Radix Ophiopogonis 600-1200g,
Ramulus Cinnamomi 1000-3000g, Rhizoma Imperatae 1000-3000g.
2, Chinese medicine preparation according to claim 1 is characterized in that the consumption of each component is:
Radix Et Rhizoma Rhei 2000g, Flos Lonicerae 6000g, Fructus Forsythiae 6000g, Cortex Phellodendri 2000g, Fructus Gardeniae 2000g,
Rhizoma Smilacis Glabrae 10000g, Indigo Naturalis 1800g, Radix Salviae Miltiorrhizae 3000g, Flos Carthami 700g, Radix Sanguisorbae 6000g,
Fructus Tribuli 2000g, Ramulus Uncariae Cum Uncis 6000g, Flos Sophorae Immaturus 12000g, Os Draconis (calcined) 6000g, Concha Ostreae (calcined)
6000g, Radix Ginseng 1000g, Fructus Lycii 2000g, Radix Ophiopogonis 1000g, Ramulus Cinnamomi 2000g,
Rhizoma Imperatae 2000g.
3, according to the production technology of Chinese medicine preparation described in claim 1 or 2, may further comprise the steps: with Os Draconis, Concha Ostreae is given as one thinks fit cataclasm, adds 8 times of water gagings and is decocted first 4 hours, filters, and filtrate and medicinal residues are standby; Radix Salviae Miltiorrhizae is with 85% alcohol reflux secondary, and each 1.5 hours, alcohol adding amount was 8 times, merge extractive liquid,, and extracting solution and medicinal residues are standby; Fructus Forsythiae, Rhizoma Smilacis Glabrae, Radix Sanguisorbae, Fructus Tribuli, the Flos Sophorae Immaturus, Ramulus Cinnamomi, Rhizoma Imperatae, Radix Ophiopogonis eight, flavor decocted with water three times with Os Draconis, Concha Ostreae, Radix Salviae Miltiorrhizae decoction dregs, decocting time was respectively 2,2,1 hours, amount of water is 8 times, collecting decoction, filter, filtrate and Os Draconis, Concha Ostreae decocting liquid merge, and are condensed into thick paste; Radix Et Rhizoma Rhei, Flos Lonicerae, Cortex Phellodendri, Fructus Gardeniae, Flos Carthami, Ramulus Uncariae Cum Uncis, Radix Ginseng, Fructus Lycii eight flavors are with 85% ethanol extraction secondary, and extraction time was respectively 2,1 hours, and alcohol adding amount is 10,8 times; Merge extractive liquid, merges with the Radix Salviae Miltiorrhizae ethanol extract, reclaims ethanol, is condensed into thick paste; Above-mentioned two thick pastes merge, and add the Indigo Naturalis powder, mixing, and drying is ground into impalpable powder, with ointment base; Fully stir, mixing, fill, promptly.
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| 中药保留灌肠治疗尿毒症48例. 徐惠霞，纪恒胜.现代中西医结合杂志，第14卷第9期. 2005 |
| 中药保留灌肠治疗尿毒症48例. 徐惠霞，纪恒胜.现代中西医结合杂志，第14卷第9期. 2005 * |
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