CN103596930B - 用作醛固酮合酶抑制剂的吡唑衍生物 - Google Patents
用作醛固酮合酶抑制剂的吡唑衍生物 Download PDFInfo
- Publication number
- CN103596930B CN103596930B CN201280028717.6A CN201280028717A CN103596930B CN 103596930 B CN103596930 B CN 103596930B CN 201280028717 A CN201280028717 A CN 201280028717A CN 103596930 B CN103596930 B CN 103596930B
- Authority
- CN
- China
- Prior art keywords
- benzonitrile
- compound
- mmol
- dimethyl
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- KWQTURRJYOIJGW-NSHDSACASA-N CC(C)(C[C@H]1c(cc2)ccc2N)C2=C1C=N[IH]2 Chemical compound CC(C)(C[C@H]1c(cc2)ccc2N)C2=C1C=N[IH]2 KWQTURRJYOIJGW-NSHDSACASA-N 0.000 description 1
- XCNNTVQRNKDCQE-UHFFFAOYSA-N N#Cc1ccc(C2c3c[nH]nc3CCC2)cc1 Chemical compound N#Cc1ccc(C2c3c[nH]nc3CCC2)cc1 XCNNTVQRNKDCQE-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161496657P | 2011-06-14 | 2011-06-14 | |
| US61/496657 | 2011-06-14 | ||
| US201161506349P | 2011-07-11 | 2011-07-11 | |
| US61/506349 | 2011-07-11 | ||
| PCT/US2012/041212 WO2012173849A1 (en) | 2011-06-14 | 2012-06-07 | Pyrazole derivatives useful as aldosterone synthase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103596930A CN103596930A (zh) | 2014-02-19 |
| CN103596930B true CN103596930B (zh) | 2015-05-13 |
Family
ID=46317515
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201280028717.6A Expired - Fee Related CN103596930B (zh) | 2011-06-14 | 2012-06-07 | 用作醛固酮合酶抑制剂的吡唑衍生物 |
Country Status (33)
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20170253577A1 (en) | 2014-07-04 | 2017-09-07 | Japan Tobacco Inc. | Method for producing indole compound |
| CN108586221B (zh) * | 2018-06-26 | 2021-03-02 | 常州制药厂有限公司 | 用于制备替卡格雷的中间体及其制备方法 |
| CN112409432B (zh) * | 2020-11-16 | 2023-07-07 | 陕西理工大学 | 一种依西美坦的合成方法 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4617307A (en) * | 1984-06-20 | 1986-10-14 | Ciba-Geigy Corporation | Substituted imidazo[1,5-A]pyridine derivatives as aromatase inhibitors |
| US5057521A (en) * | 1988-10-26 | 1991-10-15 | Ciba-Geigy Corporation | Use of bicyclic imidazole compounds for the treatment of hyperaldosteronism |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS57165369A (en) * | 1981-04-06 | 1982-10-12 | Teijin Ltd | Pyrazole derivative and its preparation |
| GT200600381A (es) * | 2005-08-25 | 2007-03-28 | Compuestos organicos | |
| JPWO2007111175A1 (ja) | 2006-03-17 | 2009-08-13 | 日本碍子株式会社 | 目封止ハニカム構造体の製造方法 |
| EP2507234B1 (en) | 2009-11-30 | 2014-03-12 | Novartis AG | Imidazole derivatives as aldosterone synthase inhibitors |
| CN102711916B (zh) | 2010-01-14 | 2015-09-02 | 诺华股份有限公司 | 肾上腺激素调节剂的用途 |
-
2012
- 2012-06-04 AR ARP120101967A patent/AR086665A1/es unknown
- 2012-06-04 TW TW101120004A patent/TWI518073B/zh not_active IP Right Cessation
- 2012-06-07 US US13/490,530 patent/US8778984B2/en not_active Expired - Fee Related
- 2012-06-07 BR BR112013031873A patent/BR112013031873A2/pt not_active IP Right Cessation
- 2012-06-07 MX MX2013014790A patent/MX336042B/es unknown
- 2012-06-07 EA EA201391655A patent/EA201391655A1/ru unknown
- 2012-06-07 HR HRP20150939TT patent/HRP20150939T1/hr unknown
- 2012-06-07 PT PT127279842T patent/PT2721009E/pt unknown
- 2012-06-07 PL PL12727984T patent/PL2721009T3/pl unknown
- 2012-06-07 RS RS20150619A patent/RS54269B1/sr unknown
- 2012-06-07 CA CA2836804A patent/CA2836804C/en not_active Expired - Fee Related
- 2012-06-07 AU AU2012271023A patent/AU2012271023A1/en not_active Abandoned
- 2012-06-07 ES ES12727984.2T patent/ES2548210T3/es active Active
- 2012-06-07 CN CN201280028717.6A patent/CN103596930B/zh not_active Expired - Fee Related
- 2012-06-07 ME MEP-2015-131A patent/ME02223B/me unknown
- 2012-06-07 PH PH1/2013/502597A patent/PH12013502597A1/en unknown
- 2012-06-07 JP JP2014515877A patent/JP5890012B2/ja not_active Expired - Fee Related
- 2012-06-07 HU HUE12727984A patent/HUE026461T2/en unknown
- 2012-06-07 WO PCT/US2012/041212 patent/WO2012173849A1/en not_active Ceased
- 2012-06-07 DK DK12727984.2T patent/DK2721009T3/en active
- 2012-06-07 PE PE2013002810A patent/PE20140606A1/es not_active Application Discontinuation
- 2012-06-07 SI SI201230283T patent/SI2721009T1/sl unknown
- 2012-06-07 SG SG2013082367A patent/SG194822A1/en unknown
- 2012-06-07 KR KR1020137032885A patent/KR101555119B1/ko not_active Expired - Fee Related
- 2012-06-07 EP EP12727984.2A patent/EP2721009B1/en active Active
-
2013
- 2013-11-18 IL IL229485A patent/IL229485A0/en unknown
- 2013-11-18 CR CR20130601A patent/CR20130601A/es unknown
- 2013-12-02 DO DO2013000284A patent/DOP2013000284A/es unknown
- 2013-12-10 CL CL2013003536A patent/CL2013003536A1/es unknown
- 2013-12-11 GT GT201300307A patent/GT201300307A/es unknown
- 2013-12-11 CO CO13290174A patent/CO6821955A2/es active IP Right Grant
- 2013-12-13 EC ECSP13013080 patent/ECSP13013080A/es unknown
-
2015
- 2015-09-11 CY CY20151100789T patent/CY1116687T1/el unknown
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4617307A (en) * | 1984-06-20 | 1986-10-14 | Ciba-Geigy Corporation | Substituted imidazo[1,5-A]pyridine derivatives as aromatase inhibitors |
| US5057521A (en) * | 1988-10-26 | 1991-10-15 | Ciba-Geigy Corporation | Use of bicyclic imidazole compounds for the treatment of hyperaldosteronism |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20150513 Termination date: 20180607 |