CN103582494A - 靶向e-钙粘着蛋白的可溶性细胞外结构域的组合物和用于癌症治疗的有关方法 - Google Patents

靶向e-钙粘着蛋白的可溶性细胞外结构域的组合物和用于癌症治疗的有关方法 Download PDF

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CN103582494A
CN103582494A CN201180063111.1A CN201180063111A CN103582494A CN 103582494 A CN103582494 A CN 103582494A CN 201180063111 A CN201180063111 A CN 201180063111A CN 103582494 A CN103582494 A CN 103582494A
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secad
cancer
antibody
methods according
cell
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萨比恩·布洛克松
M·凯利·欧巴尼昂
斯特法诺斯·吉尔卡尼德斯
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Research Foundation of the State University of New York
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
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    • G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
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    • G01N2333/4701—Details
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CN201180063111.1A 2010-10-27 2011-10-27 靶向e-钙粘着蛋白的可溶性细胞外结构域的组合物和用于癌症治疗的有关方法 Pending CN103582494A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US40736710P 2010-10-27 2010-10-27
US61/407,367 2010-10-27
PCT/US2011/058076 WO2012058418A2 (en) 2010-10-27 2011-10-27 Compositions targeting the soluble extracellular domain of e-cadherin and related methods for cancer therapy

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CN103582494A true CN103582494A (zh) 2014-02-12

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US (4) US20130287784A1 (https=)
EP (1) EP2632489B1 (https=)
JP (1) JP6243737B2 (https=)
KR (1) KR20140075639A (https=)
CN (1) CN103582494A (https=)
AU (1) AU2011319777B2 (https=)
BR (1) BR112013010535A2 (https=)
CA (1) CA2816358A1 (https=)
ES (1) ES2784385T3 (https=)
MX (2) MX357167B (https=)
RU (1) RU2013123792A (https=)
SG (3) SG10201604467PA (https=)
WO (1) WO2012058418A2 (https=)

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US9411750B2 (en) 2012-07-30 2016-08-09 International Business Machines Corporation Efficient calibration of a low power parallel data communications channel
US9474034B1 (en) 2015-11-30 2016-10-18 International Business Machines Corporation Power reduction in a parallel data communications interface using clock resynchronization
US10492104B2 (en) * 2016-03-10 2019-11-26 Cable Television Laboratories, Inc. Latency reduction in wireless service
CN109076413B (zh) 2016-03-10 2021-09-28 有线电视实验室公司 用于等待时间减少的系统和方法
US10321351B2 (en) 2017-03-02 2019-06-11 Cable Television Laboratories, Inc. System and method for grant assignment
US10738127B2 (en) 2016-06-10 2020-08-11 Veritas Biotecnologia Ltda Monoclonal antibodies prevent cell surface protein shedding and block tumor growth
US10420085B2 (en) 2016-10-07 2019-09-17 Cable Television Laboratories, Inc. System and method for grant assignment
US12225536B2 (en) 2016-10-07 2025-02-11 Cable Television Laboratories, Inc. System and method for grant assignment
US10825479B2 (en) 2018-05-11 2020-11-03 Axon Enterprise, Inc. Systems and methods for cross-redaction
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JP6243737B2 (ja) 2017-12-06
MX357167B (es) 2018-06-28
US20160046701A1 (en) 2016-02-18
WO2012058418A3 (en) 2012-07-19
MX2013004790A (es) 2014-01-17
SG10201604467PA (en) 2016-07-28
EP2632489A4 (en) 2014-06-18
US20130287784A1 (en) 2013-10-31
BR112013010535A2 (pt) 2017-11-07
SG189547A1 (en) 2013-05-31
CA2816358A1 (en) 2012-05-03
JP2014500862A (ja) 2014-01-16
SG10202100921YA (en) 2021-03-30
US20190352380A1 (en) 2019-11-21
ES2784385T3 (es) 2020-09-24
US20210380671A1 (en) 2021-12-09
WO2012058418A2 (en) 2012-05-03
MX2018007983A (es) 2023-02-23
KR20140075639A (ko) 2014-06-19
AU2011319777A1 (en) 2013-05-23
RU2013123792A (ru) 2014-12-10
EP2632489A2 (en) 2013-09-04
EP2632489B1 (en) 2020-01-15
AU2011319777B2 (en) 2016-12-08

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