CN103570605A - 特拉匹韦及其中间体的制备方法 - Google Patents
特拉匹韦及其中间体的制备方法 Download PDFInfo
- Publication number
- CN103570605A CN103570605A CN201210271785.7A CN201210271785A CN103570605A CN 103570605 A CN103570605 A CN 103570605A CN 201210271785 A CN201210271785 A CN 201210271785A CN 103570605 A CN103570605 A CN 103570605A
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- compound
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- acid salt
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- 0 CCC[C@@](C(C(NC1CC1)=O)=O)NC([C@]1N(*)C[C@]2[C@@]1CCC2)=O Chemical compound CCC[C@@](C(C(NC1CC1)=O)=O)NC([C@]1N(*)C[C@]2[C@@]1CCC2)=O 0.000 description 4
- WYVZWDMFXOZQJS-UHFFFAOYSA-N CCCC(C(C(OCCCC(C(C(O)=O)O)NC)=O)/[O]=C\C)N Chemical compound CCCC(C(C(OCCCC(C(C(O)=O)O)NC)=O)/[O]=C\C)N WYVZWDMFXOZQJS-UHFFFAOYSA-N 0.000 description 1
- RGYKFWKXQCCDNK-UHFFFAOYSA-N CCCC1OC1C(OCCCCC(C(C(O)=O)OC)N)=O Chemical compound CCCC1OC1C(OCCCCC(C(C(O)=O)OC)N)=O RGYKFWKXQCCDNK-UHFFFAOYSA-N 0.000 description 1
- FTXZHTIVOPMXBI-ZETCQYMHSA-N CCC[C@@H](C(C(NC1CC1)=O)=O)N Chemical compound CCC[C@@H](C(C(NC1CC1)=O)=O)N FTXZHTIVOPMXBI-ZETCQYMHSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/04—Formation of amino groups in compounds containing carboxyl groups
- C07C227/06—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid
- C07C227/08—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid by reaction of ammonia or amines with acids containing functional groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C269/04—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups from amines with formation of carbamate groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/48—Compounds containing oxirane rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
Abstract
Description
简称 | 中文名称 |
DIC | N,N-二异丙基碳二亚胺 |
DCC | N,N-二环己基碳二亚胺 |
HOBT | 1-羟基苯并三唑 |
EDC.HCl | 1-乙基-3-(3-二甲氨丙基)碳二亚胺盐酸盐 |
PyBOP | 六氟磷酸苯并三唑-1-基-氧基三吡咯烷基 |
PyBroP | 三吡咯烷基溴化鏻六氟磷酸盐 |
HATU | 2-(7-偶氮苯并三氮唑)-N,N,N′,N′-四甲基脲六氟磷酸酯 |
HCTU | 6-氯苯并三氮唑-1,1,3,3-四甲基脲六氟磷酸酯 |
DEPBT | 3-(二乙氧基磷酰氧基)-1,2,3-苯并三嗪-4-酮 |
EEDQ | 2-乙氧基-1-乙氧碳酰基-1,2-二氢喹啉 |
CDI | 羰基二咪唑 |
Claims (15)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201210271785.7A CN103570605B (zh) | 2012-08-01 | 2012-08-01 | 特拉匹韦及其中间体的制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201210271785.7A CN103570605B (zh) | 2012-08-01 | 2012-08-01 | 特拉匹韦及其中间体的制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN103570605A true CN103570605A (zh) | 2014-02-12 |
CN103570605B CN103570605B (zh) | 2015-08-05 |
Family
ID=50043399
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CN201210271785.7A Active CN103570605B (zh) | 2012-08-01 | 2012-08-01 | 特拉匹韦及其中间体的制备方法 |
Country Status (1)
Country | Link |
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CN (1) | CN103570605B (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105085310A (zh) * | 2014-05-15 | 2015-11-25 | 重庆汇智药物研究院有限公司 | 一种替拉瑞韦中间体的合成新方法 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20090082366A1 (en) * | 2007-09-26 | 2009-03-26 | Protia, Llc | Deuterium-enriched telaprevir |
US20100226889A1 (en) * | 2007-11-05 | 2010-09-09 | Vertex Pharmaceuticals Incorporated | HCV Combination Therapies |
US20110183895A1 (en) * | 2010-01-27 | 2011-07-28 | AB Pharma Ltd. | Polyheterocyclic compounds highly potent as hcv inhibitors |
WO2011103932A1 (en) * | 2010-02-25 | 2011-09-01 | Vereniging Voor Christelijk Hoger Onderwijs, Wetenschappelijk Onderzoek En Patiëntenzorg | A process for the preparation of substituted prolyl peptides and similar peptidomimetics |
US20120190614A1 (en) * | 2008-08-15 | 2012-07-26 | Avila Therapeutics, Inc. | Hcv protease inhibitors and uses thereof |
-
2012
- 2012-08-01 CN CN201210271785.7A patent/CN103570605B/zh active Active
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20090082366A1 (en) * | 2007-09-26 | 2009-03-26 | Protia, Llc | Deuterium-enriched telaprevir |
US20100226889A1 (en) * | 2007-11-05 | 2010-09-09 | Vertex Pharmaceuticals Incorporated | HCV Combination Therapies |
US20120190614A1 (en) * | 2008-08-15 | 2012-07-26 | Avila Therapeutics, Inc. | Hcv protease inhibitors and uses thereof |
US20110183895A1 (en) * | 2010-01-27 | 2011-07-28 | AB Pharma Ltd. | Polyheterocyclic compounds highly potent as hcv inhibitors |
WO2011103932A1 (en) * | 2010-02-25 | 2011-09-01 | Vereniging Voor Christelijk Hoger Onderwijs, Wetenschappelijk Onderzoek En Patiëntenzorg | A process for the preparation of substituted prolyl peptides and similar peptidomimetics |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105085310A (zh) * | 2014-05-15 | 2015-11-25 | 重庆汇智药物研究院有限公司 | 一种替拉瑞韦中间体的合成新方法 |
CN105085310B (zh) * | 2014-05-15 | 2017-05-10 | 重庆汇智药物研究院有限公司 | 一种替拉瑞韦中间体的合成新方法 |
Also Published As
Publication number | Publication date |
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CN103570605B (zh) | 2015-08-05 |
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Address after: No. 1479, zhangheng Road, Pudong New Area, Shanghai, 201203 Patentee after: SHANGHAI DESANO PHARMACEUTICALS INVESTMENT Co.,Ltd. Patentee after: SHANGHAI DESANO CHEMICAL PHARMACEUTICAL Co.,Ltd. Address before: No. 1479, zhangheng Road, Pudong New Area, Shanghai, 201203 Patentee before: SHANGHAI DESANO PHARMACEUTICALS INVESTMENT Co.,Ltd. Patentee before: SHANGHAI DESANO CHEMICAL PHARMACEUTICAL Co.,Ltd. |
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Effective date of registration: 20230803 Address after: 201203 floor 3, building 1, No. 1479, zhangheng Road, China (Shanghai) pilot Free Trade Zone, Pudong New Area, Shanghai Patentee after: SHANGHAI DESANO PHARMACEUTICALS INVESTMENT Co.,Ltd. Patentee after: SHANGHAI DESANO CHEMICAL PHARMACEUTICAL Co.,Ltd. Patentee after: CANGZHOU SENARY CHEMICAL SCIENCE-TEC CO.,LTD. Address before: No. 1479, zhangheng Road, Pudong New Area, Shanghai, 201203 Patentee before: SHANGHAI DESANO PHARMACEUTICALS INVESTMENT Co.,Ltd. Patentee before: SHANGHAI DESANO CHEMICAL PHARMACEUTICAL Co.,Ltd. |