CN103543279A - Portable quantitative detecting device for blood - Google Patents
Portable quantitative detecting device for blood Download PDFInfo
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- CN103543279A CN103543279A CN201310429422.6A CN201310429422A CN103543279A CN 103543279 A CN103543279 A CN 103543279A CN 201310429422 A CN201310429422 A CN 201310429422A CN 103543279 A CN103543279 A CN 103543279A
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- blood
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- 239000008280 blood Substances 0.000 title claims abstract description 76
- 210000004369 blood Anatomy 0.000 title claims abstract description 75
- 238000006243 chemical reaction Methods 0.000 claims abstract description 30
- 238000001514 detection method Methods 0.000 claims abstract description 10
- 230000002441 reversible effect Effects 0.000 claims abstract description 4
- 238000012360 testing method Methods 0.000 claims description 25
- 210000002381 plasma Anatomy 0.000 claims description 11
- 238000001914 filtration Methods 0.000 claims description 10
- 238000001228 spectrum Methods 0.000 claims description 6
- 239000000463 material Substances 0.000 claims description 5
- 239000003146 anticoagulant agent Substances 0.000 claims description 4
- 229940127219 anticoagulant drug Drugs 0.000 claims description 4
- 239000012780 transparent material Substances 0.000 claims description 4
- 239000011521 glass Substances 0.000 claims description 3
- 239000000523 sample Substances 0.000 description 69
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 18
- 239000003153 chemical reaction reagent Substances 0.000 description 6
- 210000004027 cell Anatomy 0.000 description 4
- 235000012000 cholesterol Nutrition 0.000 description 4
- 239000012528 membrane Substances 0.000 description 4
- 150000002632 lipids Chemical class 0.000 description 3
- 238000005070 sampling Methods 0.000 description 3
- HSINOMROUCMIEA-FGVHQWLLSA-N (2s,4r)-4-[(3r,5s,6r,7r,8s,9s,10s,13r,14s,17r)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-methylpentanoic acid Chemical compound C([C@@]12C)C[C@@H](O)C[C@H]1[C@@H](CC)[C@@H](O)[C@@H]1[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)C[C@H](C)C(O)=O)CC[C@H]21 HSINOMROUCMIEA-FGVHQWLLSA-N 0.000 description 2
- 239000000592 Artificial Cell Substances 0.000 description 2
- 230000003143 atherosclerotic effect Effects 0.000 description 2
- 239000003613 bile acid Substances 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 230000004060 metabolic process Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000000376 reactant Substances 0.000 description 2
- 230000000630 rising effect Effects 0.000 description 2
- 239000003270 steroid hormone Substances 0.000 description 2
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 208000007502 anemia Diseases 0.000 description 1
- 238000005842 biochemical reaction Methods 0.000 description 1
- 239000012472 biological sample Substances 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 238000004159 blood analysis Methods 0.000 description 1
- 238000009534 blood test Methods 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 208000014951 hematologic disease Diseases 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 230000003907 kidney function Effects 0.000 description 1
- 230000037356 lipid metabolism Effects 0.000 description 1
- 230000003908 liver function Effects 0.000 description 1
- 239000002075 main ingredient Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000005374 membrane filtration Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012113 quantitative test Methods 0.000 description 1
- 239000012488 sample solution Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 125000005457 triglyceride group Chemical group 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Images
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N1/10—Devices for withdrawing samples in the liquid or fluent state
- G01N1/14—Suction devices, e.g. pumps; Ejector devices
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
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- Physics & Mathematics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Hydrology & Water Resources (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
The invention discloses a portable quantitative detecting device for blood. The device sequentially comprises a blood sample collecting part, a sample introduction part and a reaction tank from top to bottom, wherein the blood sample collecting part is composed of a blood sample collecting needle tube and a needle tube fixing stopper, the blood sample collecting needle tube passes through and is fixed on the needle tube fixing stopper, the lower part of the needle tube fixing stopper is provided with a cavity, and the side of the cavity is provided with a disconnecting/connecting hole; the sample introduction part is composed of a sample introduction tube, a horizontal disconnecting tube and a sample introduction tube fixing stopper, the sample introduction tube fixing stopper is sleeved with the needle tube fixing stopper, one end of the horizontal disconnecting tube is connected into a T shape together with the sample introduction tube and can wholly rotate along with the sample introduction tube fixing stopper, and the horizontal disconnecting tube is communicated with the disconnecting/connecting hole through rotation, so that the sample introduction tube and the horizontal disconnecting tube are communicated with the atmosphere; the wall of the reaction tank has certain elasticity, so that the deformation is reversible. The device disclosed by the invention is portable, simple in operation, low in sample consumption and capable of favorably meeting the requirement for quantitative detection of clinical blood samples.
Description
Technical field
The present invention relates to a kind of biological sample quantitative testing device, a kind of portable blood quantitative testing device, belongs to medical treatment and detects apparatus technical field specifically.
Background technology
Blood test is one of modal chemical examination content of hospital, mainly by blood analysis, determines the situations such as human body anaemia, cholesterol, diabetes, various infection, renal function, calcium, liver function, hematologic disease and body be abnormal.When blood sample is carried out to biochemistry detection, generally need first remove the cell in blood, then the various materials in blood plasma be carried out to quantitative test.For example, lipid examination is mainly a kind of method for quantitatively determining that contained lipid in blood plasma is carried out.Blood fat is extensively present in human body, is the basic metabolism material of human body cell.The Main Ingredients and Appearance of blood fat is triglyceride and cholesterol, wherein, the metabolism of triglyceride participant energy i (in vivo), cholesterol is mainly used in synthetic cell serous coat, steroid hormone and bile acid.To the quantitative testing result of blood fat can antimer in the situation of lipid metabolism.Because the rising of plasma cholesterol and triglyceride level is relevant with atherosclerotic generation, these two main projects that become lipid determination.Therefore, developing a kind of portable blood quantitative testing device has very important significance.
Current existing blood sample quantitative testing device complicated operation, expensive, and volume dotes on greatly, consumes sample many, be difficult to meet instantly the particularly demand of clinical field of each field.
Summary of the invention
The weak point existing in manufacture and use procedure for existing blood testing device, the invention provides a kind of portable blood quantitative testing device, this device has advantages of easy to carry, simple to operate and sample consumption is few, can well meet the demand that clinical blood sample quantitatively detects.
The object of the present invention is achieved like this:
A quantitative testing device, it comprises blood specimen collection part, sample introduction part and reaction tank from top to down according to this; Described blood specimen collection part is comprised of blood specimen collection needle tubing, needle tubing fixed plug, and blood specimen collection needle tubing passes and is fixed in needle tubing fixed plug, and needle tubing fixed plug bottom is a cavity, and the sidepiece of described cavity is provided with blocking-up connector; Described sample introduction part is comprised of sample feeding pipe, blocking-up transverse pipe, sample feeding pipe fixed plug, sample feeding pipe fixed plug by described needle tubing fixedly plug sleeve connect, one end and the sample feeding pipe of blocking-up transverse pipe connect into T-shaped, and can be with sample feeding pipe fixed plug integral-rotation, by rotation, make to block transverse pipe and be connected with described blocking-up connector, thereby sample feeding pipe and blocking-up transverse pipe are communicated with atmosphere; Described reaction pool wall is flexible, can reversible deformation.
Preferably, portable blood quantitative testing device as above, wherein said sample feeding pipe is transparent material, end indicates scale.
Preferably, portable blood quantitative testing device as above, is provided with filtration members between wherein said blood specimen collection part and sample introduction part, and this filtration members can be passed through blood plasma, filters haemocyte.
Again further preferably, portable blood quantitative testing device as above, wherein said blood specimen collection needle tubing is glass or plastic material, applies anti-coagulants on inwall.
Again further preferably, portable blood quantitative testing device as above, wherein said blood specimen collection part is provided with over cap.
Again further preferably, portable blood quantitative testing device as above, stopped draw-in groove on wherein said blood specimen collection part and was connected with over cap.
Portable blood quantitative testing device of the present invention, wherein said pick-up unit can also comprise and the matching used spectrum detection instrument of reaction tank.
Compared with prior art, the portable blood quantitative testing device tool the present invention relates to has the following advantages and marked improvement: the present invention is integrated in one blood sample pre-service, quantitative sample injection and reaction, by extruding reaction pool wall, produce negative pressure, draw blood sample enters sample feeding pipe by filtration members, after a certain amount of sample enters, it is connected sample feeding pipe rotation with atmosphere and can makes sample enter reaction tank, blocking-up simultaneously continues sample introduction, has realized quantitative sampling; Reagent in reaction tank and plasma sample can be put into apparatus of the present invention integral body the quantitative detection that matching used spectrum detection instrument carries out sample after completing and reacting.As can be seen here, whole device volume of the present invention is little, it is convenient, simple to operate to carry, and can realize quantitative sampling, and sample is without waste.
Accompanying drawing explanation
Fig. 1 is apparatus of the present invention element composition diagram;
Fig. 2 is axial plane sectional structure chart in apparatus of the present invention;
Fig. 3 is the overall appearance schematic diagram of apparatus of the present invention;
In figure: 1-over cap, 2-blood specimen collection needle tubing, 3-needle tubing fixed plug, 4-filtration members, 5-sample feeding pipe fixed plug, 6-sample feeding pipe, 7-reaction tank, 8-reaction reagent, 9-sample feeding pipe scale mark, 10-blocks transverse pipe, the blocking-up mouthful of 11-sample feeding pipe.
Embodiment
Below in conjunction with accompanying drawing, the present invention is done further and described in detail.
Portable blood quantitative testing device of the present invention, as shown in Figure 1 and Figure 2, it arranges blood specimen collection part, filtration members, sample introduction part and reaction tank from top to down according to this; Wherein:
Blood specimen collection part is comprised of blood specimen collection needle tubing 2, needle tubing fixed plug 3, and blood specimen collection needle tubing 2 passes needle tubing fixed plug 3 and is fixed in needle tubing fixed plug 3, and needle tubing fixed plug 3 bottoms are a cavity, and the sidepiece of this cavity is provided with blocking-up connector 11; Blood specimen collection needle tubing 2 is glass or plastic material, applies anti-coagulants on inwall, in case blood sample solidifies.In addition, on blood specimen collection part, by draw-in groove, be connected with over cap 1.
Sample introduction part is comprised of sample feeding pipe 6, blocking-up transverse pipe 10, sample feeding pipe fixed plug 5, by needle tubing fixed plug 3 covers, even (needle tubing fixed plug bottom is cavity to sample feeding pipe fixed plug 5, this cavity can entangle sample feeding pipe fixed plug, thereby realizing cover connects), one end and the sample feeding pipe 6 of blocking-up transverse pipe 10 connect into T-shaped, and can by rotation, make to block transverse pipe 10 and be connected with blocking-up connector 11 with sample feeding pipe fixed plug 5 integral-rotations, thereby sample feeding pipe 6 and blocking-up transverse pipe 10 are communicated with atmosphere; Sample feeding pipe is transparent material, and end indicates scale.
Reaction tank 7 is for having the container of transparent material, and soda acid that can resistance to some strength, and reaction pool wall is flexible, can reversible deformation, in reaction tank 7, be preinstalled with the biochemical reagents 8 for reacting.
Further, matching used spectrum detection instrument can portable use, and its sample storage unit and apparatus of the present invention are in the same size, and can, according to the difference of detected object and biochemical reaction system, adopt different wave bands to detect.
Portable blood quantitative testing device of the present invention in use, by extruding reaction pool wall, produce negative pressure, draw blood sample enters sample feeding pipe by filter membrane, after a certain amount of sample enters, it is continuation sample introduction capable of blocking that sample feeding pipe rotation is connected with atmosphere, reaction reagent in blood sample reaction tube completes after reaction, device integral body can be put into the quantitative detection that matching used spectrum detection instrument carries out sample.
Below by a concrete embodiment, the present invention is described further.
Embodiment 1: the content that detects patient's Blood Cholesterol.
Cholesterol in human body is mainly used in synthetic cell serous coat, steroid hormone and bile acid.Because the rising of plasma cholesterol is relevant with atherosclerotic generation, the content of Blood Cholesterol has become an important indication of health.
Cholesterol level detects:
(1) add reactant: before device assembling, can join in blood sample reaction tube with the reactant reagent of specific lentochol reaction.
(2) device assembling: device is assembled into shown in Fig. 3 by Fig. 1 order.
(3) sampling: make its deformation with finger extruding blood sample reaction tube, use the negative pressure absorbing blood samples of patients producing when blood sample reaction tube recovers deformation, now, blood reacts with the anti-coagulants applying on sample cell inwall, guarantees that blood sample does not solidify.
(4) sample introduction: under suction function, blood sample is through membrane filtration cell, and blood plasma flows into sample feeding pipe; When range estimation flow to the specific scale of sample feeding pipe end to sample, by sample introduction part integral-rotation 180 degree, make to block transverse pipe and the connection of sample introduction blocking-up connector, now block transverse pipe and be directly communicated with atmosphere, atmosphere injects reaction tank by the blood plasma in longitudinal sample feeding pipe, and sample introduction stops.
(5) detect: after the plasma sample quantitative to be measured of inflow blood sample reaction tube fully reacts with the reaction reagent solution of pre-installing in blood sample reaction tube, whole device can be put into matching used spectrum detection instrument and quantitatively detect.
Those skilled in the art will readily understand; the foregoing is only preferred embodiment of the present invention; not in order to limit the present invention, all any modifications of doing within the spirit and principles in the present invention, be equal to and replace and improvement etc., within all should being included in protection scope of the present invention.
Claims (7)
1. a portable blood quantitative testing device, it comprises blood specimen collection part, sample introduction part and reaction tank from top to down according to this; Described blood specimen collection part is comprised of blood specimen collection needle tubing, needle tubing fixed plug, and blood specimen collection needle tubing passes and is fixed in needle tubing fixed plug, and needle tubing fixed plug bottom is a cavity, and the sidepiece of described cavity is provided with blocking-up connector; Described sample introduction part is comprised of sample feeding pipe, blocking-up transverse pipe, sample feeding pipe fixed plug, sample feeding pipe fixed plug by described needle tubing fixedly plug sleeve connect, one end and the sample feeding pipe of blocking-up transverse pipe connect into T-shaped, and can be with sample feeding pipe fixed plug integral-rotation, by rotation, make to block transverse pipe and be connected with described blocking-up connector, thereby sample feeding pipe and blocking-up transverse pipe are communicated with atmosphere; Described reaction pool wall is flexible, can reversible deformation.
2. portable blood quantitative testing device according to claim 1, is characterized in that: described sample feeding pipe is transparent material, and end indicates scale.
3. portable blood quantitative testing device according to claim 1, is characterized in that: between described blood specimen collection part and sample introduction part, be provided with filtration members, this filtration members can be passed through blood plasma, filters haemocyte.
4. portable blood quantitative testing device according to claim 1, is characterized in that: described blood specimen collection needle tubing is glass or plastic material, applies anti-coagulants on inwall.
5. according to the portable blood quantitative testing device described in claim 1-3 any one, it is characterized in that: described blood specimen collection part is provided with over cap.
6. portable blood quantitative testing device according to claim 5, is characterized in that: on described blood specimen collection part, stopped draw-in groove and be connected with over cap.
7. according to the portable blood quantitative testing device described in claim 1-3 any one, it is characterized in that: described pick-up unit also comprises and the matching used spectrum detection instrument of reaction tank.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310429422.6A CN103543279B (en) | 2013-09-22 | 2013-09-22 | Portable quantitative detecting device for blood |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310429422.6A CN103543279B (en) | 2013-09-22 | 2013-09-22 | Portable quantitative detecting device for blood |
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| Publication Number | Publication Date |
|---|---|
| CN103543279A true CN103543279A (en) | 2014-01-29 |
| CN103543279B CN103543279B (en) | 2015-05-13 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201310429422.6A Active CN103543279B (en) | 2013-09-22 | 2013-09-22 | Portable quantitative detecting device for blood |
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| Country | Link |
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| CN (1) | CN103543279B (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106456439A (en) * | 2014-03-12 | 2017-02-22 | 赛拉诺斯股份有限公司 | Systems, devices, and methods for bodily fluid sample collection |
| CN107764881A (en) * | 2017-11-27 | 2018-03-06 | 民康医疗科技（天津）有限公司 | A kind of portable blood test kit device based on electrochemical method |
| CN108872560A (en) * | 2018-08-14 | 2018-11-23 | 湖北伽诺美生物科技有限公司 | A kind of portable urine quantitative testing device |
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|---|---|---|---|---|
| EP0341586A2 (en) * | 1988-05-11 | 1989-11-15 | Dupont Canada Inc. | Apparatus for separating phases of blood |
| CN1257692A (en) * | 2000-01-25 | 2000-06-28 | 高炳源 | Syringe type expendable negative-pressure (vacuum) hemostix |
| CN2406614Y (en) * | 2000-01-05 | 2000-11-22 | 高炳源 | Disposable vacuum blood sampling syringe |
| CN1662307A (en) * | 2002-05-13 | 2005-08-31 | 贝克顿·迪金森公司 | Protease inhibitor sample collection system |
| CN1969184A (en) * | 2004-04-16 | 2007-05-23 | 拉希达·A·卡马利 | Specimen collecting, processing and analytical assembly |
| WO2011110948A2 (en) * | 2010-03-11 | 2011-09-15 | Antoine Turzi | Process,tube and device for the preparation of wound healant composition |
-
2013
- 2013-09-22 CN CN201310429422.6A patent/CN103543279B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0341586A2 (en) * | 1988-05-11 | 1989-11-15 | Dupont Canada Inc. | Apparatus for separating phases of blood |
| CN2406614Y (en) * | 2000-01-05 | 2000-11-22 | 高炳源 | Disposable vacuum blood sampling syringe |
| CN1257692A (en) * | 2000-01-25 | 2000-06-28 | 高炳源 | Syringe type expendable negative-pressure (vacuum) hemostix |
| CN1662307A (en) * | 2002-05-13 | 2005-08-31 | 贝克顿·迪金森公司 | Protease inhibitor sample collection system |
| CN1969184A (en) * | 2004-04-16 | 2007-05-23 | 拉希达·A·卡马利 | Specimen collecting, processing and analytical assembly |
| WO2011110948A2 (en) * | 2010-03-11 | 2011-09-15 | Antoine Turzi | Process,tube and device for the preparation of wound healant composition |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106456439A (en) * | 2014-03-12 | 2017-02-22 | 赛拉诺斯股份有限公司 | Systems, devices, and methods for bodily fluid sample collection |
| CN113331832A (en) * | 2014-03-12 | 2021-09-03 | 赛拉诺斯知识产权有限责任公司 | Device and method for bodily fluid sample collection |
| CN107764881A (en) * | 2017-11-27 | 2018-03-06 | 民康医疗科技（天津）有限公司 | A kind of portable blood test kit device based on electrochemical method |
| CN108872560A (en) * | 2018-08-14 | 2018-11-23 | 湖北伽诺美生物科技有限公司 | A kind of portable urine quantitative testing device |
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| Publication number | Publication date |
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| CN103543279B (en) | 2015-05-13 |
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Effective date of registration: 20170217 Address after: 430074 Wuhan high tech Avenue, No. 666 biological city innovation park, building C6, North building, building, No. 402, No. Patentee after: Wuhan Ganuo beauty Technology Co. Ltd. Address before: 430071 Hubei Province, Wuhan Province, No. 17 South Road, Hubei Province Department of water resources, building 2, unit 701, 7 Patentee before: Feng Xiaojun |
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Effective date of registration: 20190429 Address after: Room 24-2-202, Donghu Hi-tech Smart City, 216 Construction Avenue, Gedian Development Zone, Ezhou City, Hubei Province Patentee after: Hubei Ganuo beauty Biotechnology Co. Ltd. Address before: 430074 North Building 402, C6 Innovation Park, Biological City, 666 High-tech Avenue, Wuhan, Hubei Province Patentee before: Wuhan Ganuo beauty Technology Co. Ltd. |