CN103536706A - 一种治疗妊娠期念珠菌性阴道炎的中药薰洗剂 - Google Patents
一种治疗妊娠期念珠菌性阴道炎的中药薰洗剂 Download PDFInfo
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Abstract
本发明公开了一种治疗妊娠期念珠菌性阴道炎的中药薰洗剂。念珠菌性阴道炎属于中医“带下”、“阴痒”范畴，多有肝经郁热、脾虚湿盛，或肝肾阴盛、湿热蕴积于下、生虫化毒所致。本发明选择中药犁头草、大荼根、牡丹皮、鱼腥草、海桐皮、炮掌果、榆荚仁、桑根，制成薰洗剂，经我院临床对比试验证明，总有效率达到100％，具有较好的疗效，无复发。
Description
技术领域
本发明涉及一种中药组合物，尤其涉及一种治疗妊娠期念珠茵性阴道炎的中药薰洗剂。
背景技术
念珠茵性阴道炎是妇科常见病、多发病，80％～90％是由真菌中最常见的条件致病菌白色念珠菌过度生产而引起的外阴阴道感染性疾病，有5％的患者可反复发作，发病率仅次于滴虫性阴道炎。约有30％的孕妇阴道内有此真菌寄生，主要是因为妊娠期阴道上皮细胞糖原含量增加，阴道酸度大于4，加之孕妇的肾糖阈降低，常有营养性糖尿，小便中糖含量升高，促进了白色念珠菌的生长和繁殖。孕妇在妊娠期间，特别是在妊娠中、晚期，患念珠菌性阴道炎是常见的妊娠合并症，其发病率约为15％。目前单纯西医治疗效果欠佳，本人经过多年的临床观察发现，利用中药治疗妊娠期念珠菌性阴道炎具有较好的疗效。
发明内容
本发明的目的是提供一种治疗妊娠期念珠菌性阴道炎的中药薰洗剂。念珠菌性阴道炎属于中医“带下”、“阴痒”范畴，多有肝经郁热、脾虚湿盛，或肝肾阴盛、湿热蕴积于下、生虫化毒所致。
本发明的目的是通过以下技术方案实现的，该治疗妊娠期念珠菌性阴道炎的中药薰洗剂由以下重量份的中药制成：犁头草45-50份、大荼根9-15份、牡丹皮10-14份、鱼腥草12-20份、海桐皮8-16 份、炮掌果7-12份、榆荚仁14-20份、桑根15-30份。
优选的：犁头草47份、大茶根12份、牡丹皮12份、鱼腥草16份、海桐皮12份、炮掌果9.5份、榆荚仁17份、桑根23份。
制备方法：将上述药品用纱布包好，在1000mL冷水中浸泡30min后旺火煎煮25min。
方中：犁头草：清热解毒，凉血消肿；大荼根：清热解毒，消炎利尿；牡丹皮：清热凉血，利水祛湿，抑菌；鱼腥草：清热解毒，排脓消痈，利尿通淋，抑茵；海桐皮：祛风湿，通经络，杀虫；炮掌果：祛风解痉，解毒，止痒；榆荚仁：清湿热，杀虫；桑根：清热定惊，祛风通络，抑菌。
临床资料
1.一般资料选取2010年1月～2012年月12月在我院门诊就诊的妊娠期念珠茵性阴道炎妇女60例，年龄21～35岁，平均27.5岁；妊娠12～34周。在就诊的患者中，症状较重的有18例，临床表现为白带增多，外阴、阴道瘙痒、灼烧感，尿疼及性交痛；妇科检查可见：外阴发红、水肿，有抓痕，部分患者外阴及大腿内侧有大量湿疹，小阴唇内侧及阴道粘膜附有白色膜状物，用棉球擦拭后可见粘膜红肿；白带稠厚，多数呈豆渣样，念珠茵镜检阳性。症状一般的有25例，临床表现：白带增多，外阴及阴道瘙痒；妇科检查可见：
外阴发红，水肿不明显，白带为水样白带或豆渣样，小阴唇内侧及阴道粘膜附有白色膜状物，用棉球擦拭后可见粘膜红肿，部分患者可见外阴有抓痕，念珠菌镜检阳性。17例患者仅仅以外阴瘙痒就诊，妇科检查可见：外阴红肿不明显，小阴唇及阴道粘膜附有白色膜状， 用棉球擦拭后可见粘膜红肿，念珠菌镜检阳性。按照随机数字表法将60例患者随机分为治疗组和对照组，每组各30例。两组患者的年龄、孕次、孕龄、症状及病程经比较均无明显差异(P>0.01)，具有可比性。
2.诊断标准参照《实用妇产科学》。
3.治疗方法对照组采用克霉唑阴道片治疗，用药期间排除阴道流血、胎膜早破，避免性生活，夫妻同时进行治疗，将克霉唑阴道片1枚置入阴道后穹窿处。治疗组患者采用本发明所述的中药薰洗剂：称取犁头草47g、大茶根12g、牡丹皮12g、鱼腥草16g、海桐皮12g、炮掌果9.5g、榆荚仁17g、桑根23g，用纱布包好，在1000mL冷水中浸泡30min后旺火煎煮25min，取药汁熏洗15min；将克霉唑阴道片1枚置入阴道后穹窿处，每天1粒。7～10d为1个疗程。两组均治疗1个疗程，治疗期满后复查。
4.疗效标准治愈：外阴无瘙痒、灼痛、尿急及尿频症状，外阴皮肤无红肿、抓痕或皲裂；实验室检查：芽孢或假菌丝为阴性。好转：以上症状明显好转；实验室检查：芽孢或假菌丝为阴性。无效：症状无好转，体征无改善；实验室检查：芽孢或假菌丝为阳性。复发：用药后1个月随访又出现外阴瘙痒等症状。
5.治疗结果治疗后两组患者病变程度比较无显著性差(Ｐ＞0.01），疗效有显著性差异(P<0.01)。由表1可以看出，治疗组：治愈28例，治愈率为93.33％；好转2例，好转率为6.77％；无效0例，无效率为0；真菌学涂片转阴率为100％，复发0例。对照组：治愈21例，治愈率为70.00％；好转6例，好转率为20.00％；无效3例，无效 率为10.00％；真菌学涂片转阴率为86.67％；复发4例，复发率为13.33％。具体疗效对比数据见表1。
表1两组患者治疗后疗效的比较
注：与治疗组比较，P<0.01。
具体实施方式
实施例一：称取犁头草47g、大荼根12g、牡丹皮12g、鱼腥草16g、海桐皮12g、炮掌果9.5g、榆荚仁17g、桑根23g，将上述药品用纱布包好，在1000mL冷水中浸泡30min后旺火煎煮25min。
实施例二：称取犁头草45g、大茶根15g、牡丹皮10g、鱼腥草12g、海桐皮8g、炮掌果7g、榆荚仁14g、桑根30g，将上述药品用纱布包好，在1000mL冷水中浸泡30min后旺火煎煮25min。
实施例三：称取犁头草40g、大茶根9g、牡丹皮14g、鱼腥草20g、海桐皮16g、炮掌果12g、榆荚仁20g、桑根15g，将上述药品用纱布包好，在1000mL冷水中浸泡30min后旺火煎煮25min。
Claims (2)
1.一种治疗妊娠期念珠菌性阴道炎的中药薰洗剂，其特征在于该中药薰洗剂由以下重量份的中药制成：犁头草45-50份、大茶根9-15份、牡丹皮10-14份、鱼腥草12-20份、海桐皮8-16份、炮掌果7-12份、榆荚仁14-20份、桑根15-30份。
2.根据权利要求1所述的一种治疗妊娠期念珠茵性阴道炎的中药薰洗剂，其特征在于该中药薰洗剂由以下重量份的中药制成：犁头草47份、大茶根12份、牡丹皮12份、鱼腥草16份、海桐皮12份、炮掌果9.5份、榆荚仁17份、桑根23份。
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| CN1679888A (zh) * | 2005-02-03 | 2005-10-12 | 徐云裳 | 一种煮散型中药抗菌消炎剂及其制备方法和应用 |
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| Title |
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| 欧阳卫权: "中医治疗念珠菌感染的临床研究进展", 《中医药信息》, vol. 19, no. 5, 31 May 2002 (2002-05-31), pages 6 - 9 * |
| 黄露芬, 陈玲: "老年性阴道炎的中医药治疗概况", 《福建中医学院学报》, vol. 16, no. 4, 31 August 2006 (2006-08-31), pages 67 - 69 * |
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| CN104906227A (zh) * | 2015-05-09 | 2015-09-16 | 李红玲 | 一种治疗妊娠合并阴道炎的中药熏洗剂及护理方法 |
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