CN103536700B - Chinese medicinal ethosome gel patch for treating herpes zoster and preparation method thereof - Google Patents
Chinese medicinal ethosome gel patch for treating herpes zoster and preparation method thereof Download PDFInfo
- Publication number
- CN103536700B CN103536700B CN201310559445.9A CN201310559445A CN103536700B CN 103536700 B CN103536700 B CN 103536700B CN 201310559445 A CN201310559445 A CN 201310559445A CN 103536700 B CN103536700 B CN 103536700B
- Authority
- CN
- China
- Prior art keywords
- chinese medicine
- radix
- percent
- patch
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a Chinese medicinal ethosome gel patch for treating herpes zoster. The Chinese medicinal ethosome gel patch is characterized in that a therapeutic ingredient of the patch is a Chinese medicinal composition, wherein emulsion type polyacrylate is used as a pressure sensitive adhesive; the Chinese medicinal composition consists of the following materials in percentage by weight: 30 percent of liquoric root ethosome, 60 percent of water mixed decoction of gentian, white paeony root, Chinese thorowax root, angelica, root of rehmannia, szechuan lovage rhizome and szechwan chinaberry fruit, 2 percent of polyvinyl alcohol, 1 percent of gardenia, 3 percent of frankincense, 1 percent of indigo naturalis and 3 percent of borneol. The pharmacodynamics study of the patch shows that the patch has a good therapeutic effect on the early-to-mid herpes zoster and especially has better effects of shortening the course of disease, promoting deflorescence and relieving local pain. The patch is easy in medication and convenient to use, has a good therapeutic effect, quick response, strong analgesic action but no adverse reaction, and brings good social benefit and economic benefit after development and application.
Description
Technical field
The present invention relates to a kind of Chinese medicinal ethosome gel patch for the treatment of herpes zoster and preparation method thereof, belong to medical art.
Background technology
Herpes zoster is acute herpes sample dermatosis more common clinically, caused by chickenpox, varicella zoster virus, generally how to fall ill in spring.To the treatment of primary disease, modern medicine commonly uses virazole, indometacin and vitamin medicaments, but curative effect is very undesirable.Herpes zoster is a kind of resectability disease, but after herpes zoster disappears, affected part leaves over long-time pain, is referred to as post-herpetic neuralgia (postherpetic neuralgia, PHN), treats more difficult.This disease incidence rate in gerontal patient is higher, and clinical symptoms is heavier, the normal periods of months of the pain even several years.Primary disease pathogenesis is also not fully aware of, and clinical treatment is very thorny, and patient not only pain is abnormal, and uneasy round the clock, has difficulty in going to sleep, also frequently with insufferable pruritus, has a strong impact on quality of life.Doctor trained in Western medicine comprises Systemic administration, local application, nerve block, physiotherapy etc., and mainly based on symptomatic treatment, curative effect is very dissatisfied.Chinese medicine has abundant Therapeutic Method and good clinical efficacy to primary disease, take orally based on decoction at present, in addition phototherapy, acupuncture, acupoint injection therapy, acupoint massage treatment, external-use tincture, powder, rubber plaster etc., the Chinese herbs paste for the treatment of herpes zoster also belongs to blank.
Summary of the invention
The object of this invention is to provide a kind of Chinese medicinal ethosome gel patch for the treatment of herpes zoster and preparation method thereof.
The Chinese medicinal ethosome gel patch for the treatment of herpes zoster of the present invention, comprises Chinese medicine composition and pressure sensitive adhesive, and pressure sensitive adhesive is emulsion-type polyacrylate; Described Chinese medicine composition counts by weight percentage, and by glycyrol plastid 30%, Radix Gentianae, the Radix Paeoniae Alba, Radix Bupleuri, Radix Angelicae Sinensis, the Radix Rehmanniae, Rhizoma Chuanxiong, Fructus Toosendan water mix decocting liquid 60%, polyvinyl alcohol 2%, Fructus Gardeniae 1%, Olibanum 3%, Indigo Naturalis 1%, and Borneolum Syntheticum 3% formula forms.
The present invention also openly prepares the preparation method of the Chinese medicinal ethosome gel patch of described treatment herpes zoster, comprises the following steps:
(1) take Radix Glycyrrhizae as required, pulverize, by Radix Glycyrrhizae weighing scale, add 10 times amount 30% ethanol, add ammonia and adjust pH8.5 ~ 9.5, in 80 DEG C ~ 90 DEG C backflow 2h, leach medicinal residues with three layers of gauze immediately, filtrate is reclaimed ethanol after crossing 0.45 μm of filter membrane while hot and is obtained water liquid 1; Add 30% ethanol of Radix Glycyrrhizae weight 8 times amount to medicinal residues, add ammonia and adjust pH8.5 ~ 9.5, in 80 DEG C ~ 90 DEG C backflow 1h, leach medicinal residues with three layers of gauze immediately, filtrate is reclaimed ethanol after crossing 0.45 μm of filter membrane while hot and is obtained water liquid 2; Merge water liquid 1 and water liquid 2, vacuum concentration is to glycyrrhizic acid content >=50%, and moisture 15% ~ 30%, all the other are the Radix Glycyrrhizae extract beyond glycyrrhizic acid, so obtain the Radix Glycyrrhizae extract concentrated.
(2) by concentrated Gan grass put forward Qu Wu ︰ great beans Lin Zhi ︰ Dan Gu Chun ︰ dehydrated alcohol be the weight ratio of 1 ︰ 4 ︰ 0.03 ︰ 60, first dehydrated alcohol is added in the mixture of soybean phospholipid and cholesterol, concentrated Radix Glycyrrhizae extract is added after stirring and dissolving, and with high speed dispersion homogenizer 3000r/min homogenizing 1min, then within 10 minutes, namely obtain glycyrol plastid through high pressure homogenizer room temperature homogenizing.
(3) take respectively the Radix Gentianae of 1/5 Radix Glycyrrhizae amount, the Radix Paeoniae Alba, Radix Bupleuri, Radix Angelicae Sinensis, the Radix Rehmanniae, Rhizoma Chuanxiong, Fructus Toosendan, the 10 times of weight water 1h adding mixed powder after mixing coarse pulverization successively decoct twice, merge decoction liquor, cross 0.45 μm of filter membrane final vacuum while hot and be concentrated into Traditional Chinese medicine composition formula amount, add the polyvinyl alcohol of Traditional Chinese medicine composition formula amount, make it naturally swellingly dissolve to obtain Chinese medicine hydrogel.
(4) take Fructus Gardeniae, Olibanum, Indigo Naturalis, the Borneolum Syntheticum of Traditional Chinese medicine composition formula amount respectively, mixing, micronizing obtains nanoscale Chinese medicine powder.
(5) glycyrol plastid is added in Chinese medicine hydrogel, be sprinkled into nanoscale Chinese medicine powder while stirring, with high speed dispersion homogenizer 3000r/min homogenizing 1min, then within 10 minutes, namely obtain Chinese medicine composition through high pressure homogenizer room temperature homogenizing.
(6) at separate paper bottom even spread emulsion-type polyacrylate, Chinese medicine composition is evenly coated in middle level, and upper strata is even spread emulsion-type polyacrylate again, covers stretch fabric, cuts into prescribed level sealing and preserves.
Meet the requirements by general rule inspection under version " Chinese Pharmacopoeia " two annex patch items in 2010; Release experiment shows 24h release more than 90%; In-vitro percutaneous administration experiment finds that index components glycyrrhizic acid produces accumulation in skin, stops administration 3h still can glycyrrhizic acid be detected at horny layer and destratum corneum skin; Pharmacodynamic study shows, good to the Herpes Zoster of early metaphase, and particularly in the shortening course of disease, promote deflorescence, alleviating local pain aspect has good effect.The medication of this patch is simple, easy to use, and good effect, instant effect, analgesic activity is strong, and have no adverse reaction, Application and Development will produce good social effect and economic benefit.
Detailed description of the invention
Embodiment 1:
1, take Radix Glycyrrhizae 1kg, pulverize, add 10 times amount 30% ethanol, add ammonia and adjust pH8.9, in 85 DEG C of backflow 2h, leach medicinal residues with three layers of gauze immediately, filtrate is reclaimed ethanol after crossing 0.45 μm of filter membrane while hot and is obtained water liquid 1; Add 8 times amount 30% ethanol to medicinal residues, add ammonia and adjust pH9.1, in 80 DEG C ~ 90 DEG C backflow 1h, leach medicinal residues with three layers of gauze immediately, filtrate is reclaimed ethanol after crossing 0.45 μm of filter membrane while hot and is obtained water liquid 2; Merge water liquid 1 and water liquid 2, vacuum concentration obtains Radix Glycyrrhizae extract 0.1721kg, containing glycyrrhizic acid 0.1009kg, and moisture 0.0424kg.
2, first 10kg dehydrated alcohol is added in the mixture of 0.69kg soybean phospholipid and 0.0052kg cholesterol, after stirring and dissolving, the Radix Glycyrrhizae extract of preparation is all added, and with high speed dispersion homogenizer 3000r/min homogenizing 1min, again through ATS-AH-100D type extra-high-pressure nano homogenizer, under 50MPa pressure, homogenizing obtains glycyrol plastid 10.63kg in 10 minutes.
3, the Radix Gentianae of 0.2kg, the Radix Paeoniae Alba, Radix Bupleuri, Radix Angelicae Sinensis, the Radix Rehmanniae, Rhizoma Chuanxiong, Fructus Toosendan is taken respectively, add 10 times of water gaging 1h after mixing coarse pulverization successively to decoct twice, merge decoction liquor, cross 0.45 μm of filter membrane final vacuum while hot and be concentrated into 21.22kg, add 0.6kg polyvinyl alcohol, make it naturally swellingly dissolve to obtain Chinese medicine hydrogel 21.6kg.
4, take 0.3kg Fructus Gardeniae, 1kg Olibanum, 0.3kg Indigo Naturalis, 1kg Borneolum Syntheticum respectively, mixing, micronizing obtains nanoscale Chinese medicine powder 2.58kg.
5, glycyrol plastid is added in Chinese medicine hydrogel, be sprinkled into nanoscale Chinese medicine powder while stirring, with high speed dispersion homogenizer 3000r/min homogenizing 1min, then within 10 minutes, namely obtain Chinese medicine composition 35kg through high pressure homogenizer room temperature homogenizing.
6, at separate paper bottom even spread emulsion-type polyacrylate, Chinese medicine composition is evenly coated in middle level, and upper strata is even spread emulsion-type polyacrylate again, covers stretch fabric, cuts into the transdermal patch totally 175 ten thousand of 2cm × 5cm size, seal preservation respectively.The every sheet of this transdermal patch contains Chinese medicine composition >=16mg, containing index components glycyrrhizic acid >=50 μ g.
Embodiment 2:
1, take Radix Glycyrrhizae 2kg, pulverize, add 10 times amount 30% ethanol, add ammonia and adjust pH8.6, in 85 DEG C of backflow 2h, leach medicinal residues with three layers of gauze immediately, filtrate is reclaimed ethanol after crossing 0.45 μm of filter membrane while hot and is obtained water liquid 1; Add 8 times amount 30% ethanol to medicinal residues, add ammonia and adjust pH9.2, in 90 DEG C of backflow 1h, leach medicinal residues with three layers of gauze immediately, filtrate is reclaimed ethanol after crossing 0.45 μm of filter membrane while hot and is obtained water liquid 2; Merge water liquid 1 and water liquid 2, vacuum concentration obtains Radix Glycyrrhizae extract 0.2836kg, containing glycyrrhizic acid 0.2369kg, and moisture 0.0618kg.
2, first 17kg dehydrated alcohol is added in the mixture of 1.1kg soybean phospholipid and 0.0085kg cholesterol, after stirring and dissolving, the Radix Glycyrrhizae extract of preparation is all added, and with high speed dispersion homogenizer 3000r/min homogenizing 1min, again through ATS-AH-100D type extra-high-pressure nano homogenizer, under 50MPa pressure, homogenizing obtains glycyrol plastid 17.92kg in 10 minutes.
3, the Radix Gentianae of 0.4kg, the Radix Paeoniae Alba, Radix Bupleuri, Radix Angelicae Sinensis, the Radix Rehmanniae, Rhizoma Chuanxiong, Fructus Toosendan is taken respectively, add 10 times of water gaging 1h after mixing coarse pulverization successively to decoct twice, merge decoction liquor, cross 0.45 μm of filter membrane final vacuum while hot and be concentrated into 40kg, add 1kg polyvinyl alcohol, make it naturally swellingly dissolve to obtain Chinese medicine hydrogel 41kg.
4, take 0.6kg Fructus Gardeniae, 2kg Olibanum, 0.6kg Indigo Naturalis, 2kg Borneolum Syntheticum respectively, mixing, micronizing obtains nanoscale Chinese medicine powder 5.19kg.
5, glycyrol plastid is added in Chinese medicine hydrogel, be sprinkled into nanoscale Chinese medicine powder while stirring, with high speed dispersion homogenizer 3000r/min homogenizing 1min, then within 10 minutes, namely obtain Chinese medicine composition 64kg through high pressure homogenizer room temperature homogenizing.
6, at separate paper bottom even spread emulsion-type polyacrylate, Chinese medicine composition is evenly coated in middle level, and upper strata is even spread emulsion-type polyacrylate again, covers stretch fabric, cuts into the transdermal patch totally 350 ten thousand of 2cm × 5cm size, seal preservation respectively.The every sheet of this transdermal patch contains Chinese medicine composition >=16mg, containing index components glycyrrhizic acid >=50 μ g.
Pressure sensitive adhesive means a class sticky polymers that can produce under light pressure and stay without residue when adhering to and remove, and the pressure sensitive adhesive of main application in the market mainly contains polyacrylate pressure-sensitive; Oppanol type pressure sensitive adhesive; Polysiloxane type pressure sensitive adhesive.Cheap but the poor-performing of Oppanol type pressure sensitive adhesive; Polysiloxane type pressure sensitive adhesive characteristic is better but expensive; Need use a large amount of organic solvent when general polyacrylate pressure-sensitive uses, cost height also not environmentally, uses and often causes skin whiting even to damage; Emulsion-type polyacrylate pressure-sensitive is non-stimulated to skin, there is high non-oxidizability, do not need to add antioxidant and stabilizing agent, there is suitable glass transition temperature and good viscosity, plasticizer or the viscosifier of low molecule quality can not be added, functional.
Embodiment 3: pharmacodynamic study
1, object of study
Selected objects all from Affiliated Hospital of Yangzhou University Dermatology Outpatient Department patient, totally 63 routine Chinese herbs paste treatment group 31 examples (1 example comes off), matched group 32 example (1 example comes off).Allly enter to organize patient and all sign and write notice in the know.
2, diagnostic criteria
Skin cypridology with reference to People's Health Publisher's publication in 2008:
(1) slightly weak, the General Symptoms such as low grade fever, poor appetite is had before dermexanthesis;
(2) the conscious scorching hot or causalgia of illing skin, that touches has obvious Hyperalgesia;
(3) predilection site is intercostal nerves, cervical nerves, y-bend nerve and waist bones of the body innervation region;
(4) there is flushing speckle in skin lesion Chang Shouxian, occurs that foxtail millet grain is to Semen Glycines size pimple very soon, and tufted distributes and do not merge, and then become rapidly water scar, cellulitis wall is thin, and lump liquid is clarified;
(5) skin lesion is zonation along a certain peripheral nerve, mostly occurs in the side of health, is generally no more than
Median line;
(6) general 2 one 3 weeks of the course of disease, old people is 3 one 4 weeks, water cellulitis is dry, knot is silly come off after leave temporary light red speckle or pigmentation:
(7) Special Manifestations such as an indomethacin, ear indomethacin can still be had "
3, Therapeutic Method
Two groups of methods all adopting Experience of Combined Treatment of Internal Medicine to add (comprising quiet antiviral drugs acyclovir, oral pain alleviating agent, the aggregate measures such as intramuscular injection trophic nerve medicine vitamin B1, mecobalamin) topical therapeutic.Matched group uses acyclovir ointment external, and every day smears affected part 4-5 time.Chinese herbs paste treatment group of the present invention is pressed skin lesion size and is used, and every 7 days was 1 course for the treatment of, and according to the state of an illness, continuous 2 courses for the treatment of, if lesions of patients disappears, pain disappears, and both can stop Chinese herbs paste.If local skin lesion water scar) ICm, feasible scar liquid extracts postoperative, then external application medicine.Treatments period taboo is drunk, and avoids edible pungent! Stimulate food, the mechanical irritation such as avoid skin lesion place to scratch, in order to avoid the observation that affects the treatment, " within 1 week, be 1 course for the treatment of, Continuous Observation 2 weeks, patient, in further consultation in the 7th, 14 day, observes and notes down index.Followed up a case by regular visits to patient at the 30th day, whether record there is post herpetic neuralgia, and the number of cases that record occurs.
4, efficacy evaluation
Skin lesion observation index
(1) skin lesion area:
According to versions " new Chinese medicine guideline of clinical investigations " in 2002 and pertinent literature
0 point without skin lesion
1 point of skin lesion area <50cm2
3 points of skin lesion area 50emZ mono-99Cm2
5 points of skin lesion areas) 100cm2
(2) erythema:
0 point without erythema
1 point of light red speckle
2 points of edema type erythema
3 points of scarlet speckles of edema type
4 points of purplish-red maculas
(3) water cellulitis
O divides anhydrous scar
1 point of Mild edema or water scar are subsided, tie silly
2 are dispersed in needle point to foxtail millet grain Taegu scar rash
3 points of intensive mound skin ulcer rash, water lumps
4 points of pus lumps, blood cellulitis or large cellulitis
Observation of pain index
Adopt 6 behavior scoring methods (BRS 1), be divided into six grades according to banded lump rash pain feature:
0 point without pain
1 point has pain, but can be ignored easily
2 points have pain to ignore, affect daily life
3 points have pain, cannot ignore, disturbance of concentration
4 points daytime pain cannot ignore, disturbance of concentration, night, the pain increased impact sleep
5 points of existence have an intense pain, and affect daily life and sleep
The standard of curative effect evaluation
Adopt nimodipine method, curative effect judging standard is divided into recovery from illness, effective, effective, invalid 4 grades "
(1) fully recover: recovery from illness :≤90% deflorescence, clinical sign disappears without pain, does not stay any sequela,
Therapeutic index >=90%
(2) effective :≤70% skin lesion disappears, and pain obviously alleviates, therapeutic index > 60%, <90%
It is (3) effective: skin lesion disappears %30%, <70%, pain relief,
(4) invalid: skin lesion disappears <30%, pain without obviously alleviating, therapeutic index <30%
Therapeutic index <30%
5, result of study
Case enters to organize condition
This research is included 63 routine Patients with Herpes Zosters altogether in and is entered clinical trial, treatment group 31 example after random packet, and 30 examples complete total Test, and come off 1 example; Matched group 32 example, 31 examples complete total Test, and come off 1 example.Have 62 examples and meet scheme.Treatment group 1 example because running counter to therapeutic scheme, by the process that comes off, matched group 1 example because of working principle therapy discontinued, also by the process that comes off.
Two groups of harmonies compare
From sex treatment group 31 example, wherein male 16 example, women 15 example; Matched group 30 example, wherein male 17 example, women 14 example.Through X 2 test, two groups of Genders compare χ
2=0.127, P=0.810, P>0.05.
Two groups of patient age distributions are compared, treatment group 31 example, 18 ~ 44 years old 12 example, 45 ~ 60 years old 13 example, 61 ~ 75 years old 6 example, mean age
matched group 30 example, 18 ~ 44 years old 14 example, 45 ~ 60 years old 11 example, 61 ~ 75 years old 5 example, matched group mean age
through independent samples t test, statistic t=0.064, P=0.891, P>0.05.
The comparison of two groups of patient's courses of disease, treatment group 31 example, 1 ~ 3 day 20 example, 4 ~ 5 days 11 examples, average course of disease 3.25 days; Matched group 30 example, 1 ~ 3 day 21 example, 4 ~ 5 days 9 examples, average course of disease 3.13 days.Through X 2 test, two groups of patient census measure χ
2=0.473, P=0.613, P>0.05.
Two groups of morbidity positions are compared, treatment group 31 example, and site of pathological change is 5 examples, 8 examples in breast side of body portion, 14 examples of waist and belly, buttocks lower limb portion 4 example in shoulder neck upper limb portion; Matched group 30 example, site of pathological change is 4 examples, 9 examples in breast side of body portion, 12 examples of waist and belly, buttocks lower limb portion 5 example in shoulder neck upper limb portion.Through X 2 test, two groups of patient census measure χ
2=0.757, P=0.823, P>0.05.
Two groups of patient condition quantize total mark and compare, treatment group 31 example,
matched group 30 example,
through independent samples t test, statistic t=0.216, P=0.753, P>0.05.
7, efficacy analysis
Two groups of lesions of patients integral contrasts
As can be seen from table 1-2, in skin lesion disappears, after the treatment, two groups of patients after the treatment the 1st, 11,14 day, no significant difference, and the 2nd, 3,4,7,9 day after the treatment, treatment group is better than matched group to two groups of patients.
After table 1 liang group patient treatment, the skin lesion integration change of first week is compared
After table 2 liang group patient treatment, the skin lesion integration change of second week is compared
Through independent samples t-test, treatment after the 1st, 11,14 day two groups compare the equal >0.05 of P; Latter 2nd, 3,4,7,9 day for the treatment of, the equal <0.05 of comparison P of two groups of integrations
Compare with after treatment before treatment group treatment, t=23.103, P<0.001, before and after treatment, difference has statistical significance; Compare before treatment of control group with after treatment, t=20.107, P<0.001, before and after treatment, difference has statistical significance.
Two groups of patient pain's integral contrasts
As can be seen from table 3-4, in pain relief, two groups of patients the 1st, 9,11,14 day after the treatment, zero difference, and the 2nd, 3,4,7 day after the treatment, treatment group is better than matched group.
After table 3 liang group patient treatment, pain integration change in first week is compared
After table 4 liang group patient treatment, the change of second week pain integration is compared
Through independent samples t-test, latter 1st, 9,11,14 day for the treatment of, two groups are compared the equal >0.05 of P; Latter 2nd, 3,4,7 day for the treatment of, two groups of equal <0.05 of the P compared
Compare with after treatment before treatment group treatment, t=20.386, P<0.001, before and after treatment, difference has statistical significance; Compare before treatment of control group with after treatment, t=22.013, P<0.001, before and after treatment, difference has statistical significance.
The transference cure time compares
As can be seen from Table 5, in only bleb time, scab forming time, decrustation, the time compares, two groups are compared zero difference, and on erythema regression time, analgesic time and pain disappearing time, treatment group is better than matched group.
The table 5 liang group transference cure time (my god) compare
Through independent samples t-test, two groups are stopped the bleb time, scab forming time, decrustation time compares, the equal >0.05 of P value; And two groups of erythema regression times, analgesic time, pain disappearing times compare, the equal <0.05 of P value
Medicine for external use treatment time compares
As can be seen from Table 6, two groups of patient's medicine for external use treatment time zero differences.
Table 6 liang group patient's medicine for external use time (my god) compare
Through non parametric tests, two groups of external used medicine times compare, statistic χ
2=0.673, P=0.723, P>0.05
General curative effect compares
As can be seen from Table 7, two groups of patients are all effective in cure, and at the no significant difference of cure rate, total obvious effective rate and total effective rate between two groups.
A table 7 liang group general curative effect compares
Check through nonparametric Mann-Whitney U, statistic Z=-0.765, P=0.426, P>0.05
There is post herpetic neuralgia situation analysis in patient
Latter 30th day for the treatment of, there is post herpetic neuralgia situation and compares in table 8 in two groups of patients.Wherein treatment group has 1 example that post herpetic neuralgia occurs, and accounts for 3.45% of total effectively number of cases; Matched group has 2 examples that post herpetic neuralgia occurs, and accounts for 7.41% of total effectively number of cases.The incidence rate zero difference of two groups of post herpetic neuralgias.
There is post herpetic neuralgia situation after table 8 liang group patient treatment to compare
Through X 2 test, χ
2=0.413, P=0.507, P>0.05.
Claims (1)
1. treat a preparation method for the Chinese medicinal ethosome gel patch of herpes zoster, it is characterized in that comprising the following steps:
(1) take Radix Glycyrrhizae as required, pulverize, by Radix Glycyrrhizae weighing scale, add 10 times amount 30% ethanol, add ammonia and adjust pH8.5 ~ 9.5, in 80 DEG C ~ 90 DEG C backflow 2 h, leach medicinal residues with three layers of gauze immediately, filtrate is reclaimed ethanol after crossing 0.45 μm of filter membrane while hot and is obtained water liquid 1; Add 30% ethanol of Radix Glycyrrhizae weight 8 times amount to medicinal residues, add ammonia and adjust pH8.5 ~ 9.5, in 80 DEG C ~ 90 DEG C backflow 1 h, leach medicinal residues with three layers of gauze immediately, filtrate is reclaimed ethanol after crossing 0.45 μm of filter membrane while hot and is obtained water liquid 2; Merge water liquid 1 and water liquid 2, vacuum concentration to glycyrrhizic acid content >=50%, moisture 15% ~ 30%, all the other are the Radix Glycyrrhizae extract beyond glycyrrhizic acid, so obtain the Radix Glycyrrhizae extract concentrated;
(2) by concentrated Gan grass put forward Qu Wu ︰ great beans Lin Zhi ︰ Dan Gu Chun ︰ dehydrated alcohol be the weight ratio of 1 ︰ 4 ︰ 0.03 ︰ 60, first dehydrated alcohol is added in the mixture of soybean phospholipid and cholesterol, concentrated Radix Glycyrrhizae extract is added after stirring and dissolving, and with high speed dispersion homogenizer 3000r/min homogenizing 1min, then within 10 minutes, namely obtain glycyrol plastid through high pressure homogenizer room temperature homogenizing;
(3) Radix Gentianae of 1/5 Radix Glycyrrhizae amount, the Radix Paeoniae Alba, Radix Bupleuri, Radix Angelicae Sinensis, the Radix Rehmanniae, Rhizoma Chuanxiong, Fructus Toosendan is taken respectively, the 10 times of weight water 1h adding mixed powder after mixing coarse pulverization successively decoct twice, merge decoction liquor, cross 0.45 μm of filter membrane final vacuum while hot and be concentrated into Traditional Chinese medicine composition formula amount, add the polyvinyl alcohol of Traditional Chinese medicine composition formula amount, make it naturally swellingly dissolve to obtain Chinese medicine hydrogel; The formula of described Chinese medicine composition is: glycyrol plastid 30%, and Radix Gentianae, the Radix Paeoniae Alba, Radix Bupleuri, Radix Angelicae Sinensis, the Radix Rehmanniae, Rhizoma Chuanxiong, Fructus Toosendan water mix decocting liquid 60%, polyvinyl alcohol 2%, Fructus Gardeniae 1%, Olibanum 3%, Indigo Naturalis 1%, Borneolum Syntheticum 3%;
(4) take the Fructus Gardeniae of Traditional Chinese medicine composition formula amount, Olibanum, Indigo Naturalis, Borneolum Syntheticum respectively, mixing, micronizing obtains nanoscale Chinese medicine powder;
(5) glycyrol plastid is added in Chinese medicine hydrogel, be sprinkled into nanoscale Chinese medicine powder while stirring, with high speed dispersion homogenizer 3000r/min homogenizing 1min, then within 10 minutes, namely obtain Chinese medicine composition through high pressure homogenizer room temperature homogenizing;
(6) at separate paper bottom even spread emulsion-type polyacrylate, Chinese medicine composition is evenly coated in middle level, and upper strata is even spread emulsion-type polyacrylate again, covers stretch fabric, cuts into prescribed level sealing and preserves.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310559445.9A CN103536700B (en) | 2013-11-12 | 2013-11-12 | Chinese medicinal ethosome gel patch for treating herpes zoster and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310559445.9A CN103536700B (en) | 2013-11-12 | 2013-11-12 | Chinese medicinal ethosome gel patch for treating herpes zoster and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103536700A CN103536700A (en) | 2014-01-29 |
| CN103536700B true CN103536700B (en) | 2015-04-22 |
Family
ID=49960814
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310559445.9A Expired - Fee Related CN103536700B (en) | 2013-11-12 | 2013-11-12 | Chinese medicinal ethosome gel patch for treating herpes zoster and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103536700B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105311417A (en) * | 2015-12-02 | 2016-02-10 | 卢雨萍 | Externally applied traditional Chinese medicine for treating herpes zoster |
| CN117618400B (en) * | 2023-11-29 | 2024-07-26 | 北京烨桦疑难病中医研究院 | Composite traditional Chinese medicine mist absorbing preparation for improving immunity and preparation method thereof |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1357348A (en) * | 2000-12-08 | 2002-07-10 | 汤道荃 | Zoster treating liniment |
| CN100544730C (en) * | 2005-09-28 | 2009-09-30 | 江苏正大天晴药业股份有限公司 | Magnesium isoglycyrrhetate external preparation and its production and application |
| CN101347554B (en) * | 2008-08-29 | 2010-12-08 | 刘运波 | Chinese medicine for treating zoster |
| US7862838B1 (en) * | 2009-08-31 | 2011-01-04 | Qing Si Zeng | Composition and regimen for the treatment of herpes simplex and herpes zoster primarily by eliminating their pathogenetic conditions and taking into account both pathogenesis and etiology |
| CN103181895A (en) * | 2011-12-29 | 2013-07-03 | 南京农业大学 | Glycyrrhetinic acid nano-liposome for improving immune function of livestock and poultry and its preparation method |
-
2013
- 2013-11-12 CN CN201310559445.9A patent/CN103536700B/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN103536700A (en) | 2014-01-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102579652B (en) | Medicine for treating lumbar disc herniation and preparation method thereof | |
| CN102068474A (en) | Capparis spinosa fruit gel ointment, production method thereof, and application thereof to antirheumatic medicaments | |
| CN103536700B (en) | Chinese medicinal ethosome gel patch for treating herpes zoster and preparation method thereof | |
| WO2014059880A1 (en) | Method for preparation of pomegranate-peel polyphenol gel used to treat gynecological inflammation | |
| CN102716394B (en) | Medicine composition for treating skin diseases | |
| CN106176784B (en) | It is a kind of for the pharmaceutical composition of dermatitis, application, preparation and preparation method thereof | |
| CN100444889C (en) | Chinese medicinal composition for treating mastopathy | |
| CN101934015B (en) | Traditional Chinese medicinal composition for treating thyroid and method for preparing dispelling-goitre cataplasm thereof | |
| CN103263470B (en) | Swelling-decreasing and pain-relieving traditional Chinese medicine gel and preparation method thereof | |
| CN104352616A (en) | Traditional Chinese medicine composition for treating sciatica and preparation method thereof | |
| CN104013818A (en) | Plaster for treating cancer pains | |
| CN104524247B (en) | One treats migrainous medical composition and its use | |
| US8658227B2 (en) | Botanical formulation derived from birch bark | |
| CN104623376A (en) | Medicament for treating prosopalgia | |
| WO2017206016A1 (en) | Anti-inflammation and swelling-relief traditional chinese ointment for external application | |
| CN105362382A (en) | Traditional Chinese medicine composition for treating recurrent oral ulcer and application thereof | |
| CN106236791A (en) | Total alkaloid of harmaline ointment and preparation method thereof | |
| CN104784313A (en) | Externally-applied traditional Chinese medicine preparation for treating eczema | |
| CN100375633C (en) | Psychotria serpens total sterol and its medicinal composition and use | |
| CN104324332A (en) | Traditional Chinese medicine preparation for treating liver-qi stagnation type chloasma and production method of traditional Chinese medicine preparation | |
| CN103520367A (en) | Pharmaceutical composition for treating urticaria, and preparation method and application thereof | |
| CN103494938B (en) | Application of catalpol in preparing medicine for treating oral ulcer | |
| CN103385937B (en) | Traditional Chinese medicine preparation for preventing and treating herpes zoster and postherpetic neuralgia and preparation method thereof | |
| CN102302583B (en) | Medicinal composition for reducing swelling and alleviating pain | |
| CN104173466B (en) | Compound pyrrosia leaf dispersible tablet and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20150422 Termination date: 20171112 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |