CN103536700A - Chinese medicinal ethosome gel patch for treating herpes zoster and preparation method thereof - Google Patents
Chinese medicinal ethosome gel patch for treating herpes zoster and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a Chinese medicinal ethosome gel patch for treating herpes zoster. The Chinese medicinal ethosome gel patch is characterized in that a therapeutic ingredient of the patch is a Chinese medicinal composition, wherein emulsion type polyacrylate is used as a pressure sensitive adhesive; the Chinese medicinal composition consists of the following materials in percentage by weight: 30 percent of liquoric root ethosome, 60 percent of water mixed decoction of gentian, white paeony root, Chinese thorowax root, angelica, root of rehmannia, szechuan lovage rhizome and szechwan chinaberry fruit, 2 percent of polyvinyl alcohol, 1 percent of gardenia, 3 percent of frankincense, 1 percent of indigo naturalis and 3 percent of borneol. The pharmacodynamics study of the patch shows that the patch has a good therapeutic effect on the early-to-mid herpes zoster and especially has better effects of shortening the course of disease, promoting deflorescence and relieving local pain. The patch is easy in medication and convenient to use, has a good therapeutic effect, quick response, strong analgesic action but no adverse reaction, and brings good social benefit and economic benefit after development and application.
Description
Technical field
The present invention relates to a kind of Chinese medicine Ethosomal gel patch for the treatment of herpes zoster and preparation method thereof, belong to medical technical field.
Background technology
Herpes zoster is clinically more common acute herpes sample dermatosis, due to chickenpox, varicella zoster virus, and general how morbidity in spring.Treatment to primary disease, modern medicine is commonly used virazole, indometacin and vitamin medicaments, but curative effect is very undesirable.Herpes zoster is a kind of resectability disease, but after herpes zoster disappears, affected part is left over long-time pain, is referred to as post-herpetic neuralgia (postherpetic neuralgia, PHN), treats more difficult.This disease incidence rate in gerontal patient is higher, and clinical symptoms is heavier, and pain often continues several years even several months.Primary disease pathogenesis is also not fully aware of, and clinical treatment is very thorny, and patient not only pain is abnormal, and uneasy round the clock, has difficulty in going to sleep, and also, frequently with insufferable pruritus, has a strong impact on quality of life.Doctor trained in Western medicine comprises system medication, local application, nerve block, physiotherapy etc., mainly take symptomatic treatment as main, and curative effect is very dissatisfied.Chinese medicine has abundant Therapeutic Method and good clinical efficacy to primary disease, the decoction of take at present takes orally as main, in addition phototherapy, acupuncture, acupoint injection therapy, acupoint massage treatment, external-use tincture, powder, rubber plaster etc., the Chinese herbs paste for the treatment of herpes zoster also belongs to blank.
Summary of the invention
The object of this invention is to provide a kind of Chinese medicine Ethosomal gel patch for the treatment of herpes zoster and preparation method thereof.
The Chinese medicine Ethosomal gel patch for the treatment of herpes zoster of the present invention, comprises Chinese medicine composition and pressure sensitive adhesive, and pressure sensitive adhesive is emulsion-type polyacrylate; Described Chinese medicine composition counts by weight percentage, by glycyrol plastid 30%, and Radix Gentianae, the Radix Paeoniae Alba, Radix Bupleuri, Radix Angelicae Sinensis, the Radix Rehmanniae, Rhizoma Chuanxiong, the mixed decocting liquid 60% of Fructus Toosendan water, polyvinyl alcohol 2%, Fructus Gardeniae 1%, Olibanum 3%, Indigo Naturalis 1%, Borneolum Syntheticum 3% formula forms.
The present invention also openly prepares the preparation method of the Chinese medicine Ethosomal gel patch of described treatment herpes zoster, comprises the following steps:
(1) take as required Radix Glycyrrhizae, pulverize, by Radix Glycyrrhizae weighing scale, add 10 times of amount 30% ethanol, add ammonia and adjust pH8.5～9.5, in 80 ℃～90 ℃ backflow 2h, with three layers of gauze, leach medicinal residues immediately, filtrate while hot reclaim ethanol after 0.45 μ m filter membrane and obtain water liquid 1; 30% ethanol that adds 8 times of amounts of Radix Glycyrrhizae weight to medicinal residues, adds ammonia and adjusts pH8.5～9.5, in 80 ℃～90 ℃ backflow 1h, leaches medicinal residues immediately with three layers of gauze, and filtrate is reclaimed ethanol after mistake 0.45 μ m filter membrane while hot and obtained water liquid 2; Merge water liquid 1 and water liquid 2, vacuum concentration is to glycyrrhizic acid content >=50%, moisture 15%～30%, and all the other be glycyrrhizic acid Radix Glycyrrhizae extract in addition, so obtain concentrated Radix Glycyrrhizae extract.
(2) by concentrated Gan grass Ti Qu Wu ︰ great beans Lin Zhi ︰ Dan Gu Chun ︰ dehydrated alcohol, be the weight ratio of 1 ︰ 4 ︰ 0.03 ︰ 60, first dehydrated alcohol is added in the mixture of soybean phospholipid and cholesterol, after stirring and dissolving, add concentrated Radix Glycyrrhizae extract, and with high speed dispersion homogenizer 3000r/min homogenizing 1min, then within 10 minutes, obtain glycyrol plastid through high pressure homogenizer room temperature homogenizing.
(3) take respectively 1/5 Radix Glycyrrhizae amount Radix Gentianae, the Radix Paeoniae Alba, Radix Bupleuri, Radix Angelicae Sinensis, the Radix Rehmanniae,, Rhizoma Chuanxiong, Fructus Toosendan, 10 times of weight water 1h that add mixed powder after mixing coarse pulverization successively decoct twice, merge decoction liquor, cross while hot 0.45 μ m filter membrane final vacuum and be concentrated into Chinese medicine composition formula ratio, the polyvinyl alcohol that adds Chinese medicine composition formula ratio, makes its natural swelling dissolve to obtain Chinese medicine hydrogel.
(4) take respectively Fructus Gardeniae, Olibanum, Indigo Naturalis, the Borneolum Syntheticum of Chinese medicine composition formula ratio, mix, micronizing obtains nanoscale Chinese medicine powder.
(5) glycyrol plastid is added in Chinese medicine hydrogel, be sprinkled into while stirring nanoscale Chinese medicine powder, with high speed dispersion homogenizer 3000r/min homogenizing 1min, then within 10 minutes, obtain Chinese medicine composition through high pressure homogenizer room temperature homogenizing.
(6) at separate paper bottom, be evenly coated with emulsion-type polyacrylate, Chinese medicine composition is evenly coated in middle level, and upper strata is evenly coated with emulsion-type polyacrylate again, covers stretch fabric, cuts into prescribed level sealing and preserves.
By general rule inspection under bis-appendix patch items of version < < Chinese Pharmacopoeia > > in 2010, meet the requirements; Release experiment shows that 24h release is more than 90%; In-vitro percutaneous administration experiment finds that index components glycyrrhizic acid produces and accumulates in skin, stops administration 3h and still glycyrrhizic acid can be detected at horny layer and destratum corneum skin; Pharmacodynamic study shows, good to the Herpes Zoster of early metaphase, particularly, shortening the course of disease, promotes deflorescence, and alleviating local pain aspect has good effect.The medication of this patch is simple, easy to use, and good effect, instant effect, and analgesic activity is strong, has no adverse reaction, and Application and Development will produce good social effect and economic benefit.
The specific embodiment
Embodiment 1:
1, take Radix Glycyrrhizae 1kg, pulverize, add 10 times of amount 30% ethanol, add ammonia and adjust pH8.9, in 85 ℃ of backflow 2h, leach medicinal residues immediately with three layers of gauze, filtrate is reclaimed ethanol after mistake 0.45 μ m filter membrane while hot and is obtained water liquid 1; To medicinal residues, add 8 times of amount 30% ethanol, add ammonia and adjust pH9.1, in 80 ℃～90 ℃ backflow 1h, leach medicinal residues immediately with three layers of gauze, filtrate is reclaimed ethanol after mistake 0.45 μ m filter membrane while hot and is obtained water liquid 2; Merge water liquid 1 and water liquid 2, vacuum concentration obtains Radix Glycyrrhizae extract 0.1721kg, containing glycyrrhizic acid 0.1009kg, and moisture 0.0424kg.
2, first 10kg dehydrated alcohol is added in the mixture of 0.69kg soybean phospholipid and 0.0052kg cholesterol, after stirring and dissolving, the Radix Glycyrrhizae extract of preparation is all added, and with high speed dispersion homogenizer 3000r/min homogenizing 1min, through ATS-AH-100D type supertension nanometer homogenizer, under 50MPa pressure, homogenizing obtains glycyrol plastid 10.63kg for 10 minutes again.
3, take respectively Radix Gentianae, the Radix Paeoniae Alba, Radix Bupleuri, Radix Angelicae Sinensis, the Radix Rehmanniae, Rhizoma Chuanxiong, the Fructus Toosendan of 0.2kg, after mixing coarse pulverization, adding 10 times of water gaging 1h successively decocts twice, merge decoction liquor, cross while hot 0.45 μ m filter membrane final vacuum and be concentrated into 21.22kg, add 0.6kg polyvinyl alcohol, make its natural swelling dissolve to obtain Chinese medicine hydrogel 21.6kg.
4, take respectively 0.3kg Fructus Gardeniae, 1kg Olibanum, 0.3kg Indigo Naturalis, 1kg Borneolum Syntheticum, mix, micronizing obtains nanoscale Chinese medicine powder 2.58kg.
5, glycyrol plastid is added in Chinese medicine hydrogel, be sprinkled into while stirring nanoscale Chinese medicine powder, with high speed dispersion homogenizer 3000r/min homogenizing 1min, then within 10 minutes, obtain Chinese medicine composition 35kg through high pressure homogenizer room temperature homogenizing.
6, at separate paper bottom, be evenly coated with emulsion-type polyacrylate, Chinese medicine composition is evenly coated in middle level, and upper strata is evenly coated with emulsion-type polyacrylate again, covers stretch fabric, cuts into totally 175 ten thousand of the transdermal patches of 2cm * 5cm size, and sealing is preserved respectively.Every of this transdermal patch contains Chinese medicine composition >=16mg, containing index components glycyrrhizic acid >=50 μ g.
Embodiment 2:
1, take Radix Glycyrrhizae 2kg, pulverize, add 10 times of amount 30% ethanol, add ammonia and adjust pH8.6, in 85 ℃ of backflow 2h, leach medicinal residues immediately with three layers of gauze, filtrate is reclaimed ethanol after mistake 0.45 μ m filter membrane while hot and is obtained water liquid 1; To medicinal residues, add 8 times of amount 30% ethanol, add ammonia and adjust pH9.2, in 90 ℃ of backflow 1h, leach medicinal residues immediately with three layers of gauze, filtrate is reclaimed ethanol after mistake 0.45 μ m filter membrane while hot and is obtained water liquid 2; Merge water liquid 1 and water liquid 2, vacuum concentration obtains Radix Glycyrrhizae extract 0.2836kg, containing glycyrrhizic acid 0.2369kg, and moisture 0.0618kg.
2, first 17kg dehydrated alcohol is added in the mixture of 1.1kg soybean phospholipid and 0.0085kg cholesterol, after stirring and dissolving, the Radix Glycyrrhizae extract of preparation is all added, and with high speed dispersion homogenizer 3000r/min homogenizing 1min, through ATS-AH-100D type supertension nanometer homogenizer, under 50MPa pressure, homogenizing obtains glycyrol plastid 17.92kg for 10 minutes again.
3, take respectively Radix Gentianae, the Radix Paeoniae Alba, Radix Bupleuri, Radix Angelicae Sinensis, the Radix Rehmanniae, Rhizoma Chuanxiong, the Fructus Toosendan of 0.4kg, after mixing coarse pulverization, adding 10 times of water gaging 1h successively decocts twice, merge decoction liquor, cross while hot 0.45 μ m filter membrane final vacuum and be concentrated into 40kg, add 1kg polyvinyl alcohol, make its natural swelling dissolve to obtain Chinese medicine hydrogel 41kg.
4, take respectively 0.6kg Fructus Gardeniae, 2kg Olibanum, 0.6kg Indigo Naturalis, 2kg Borneolum Syntheticum, mix, micronizing obtains nanoscale Chinese medicine powder 5.19kg.
5, glycyrol plastid is added in Chinese medicine hydrogel, be sprinkled into while stirring nanoscale Chinese medicine powder, with high speed dispersion homogenizer 3000r/min homogenizing 1min, then within 10 minutes, obtain Chinese medicine composition 64kg through high pressure homogenizer room temperature homogenizing.
6, at separate paper bottom, be evenly coated with emulsion-type polyacrylate, Chinese medicine composition is evenly coated in middle level, and upper strata is evenly coated with emulsion-type polyacrylate again, covers stretch fabric, cuts into totally 350 ten thousand of the transdermal patches of 2cm * 5cm size, and sealing is preserved respectively.Every of this transdermal patch contains Chinese medicine composition >=16mg, containing index components glycyrrhizic acid >=50 μ g.
Pressure sensitive adhesive means and under light pressure, can produce a class sticky polymers that adheres to and stay without residue while removing, and the pressure sensitive adhesive of main application mainly contains polyacrylate pressure-sensitive in the market; Oppanol type pressure sensitive adhesive; Polysiloxane type pressure sensitive adhesive.Cheap but the poor-performing of Oppanol type pressure sensitive adhesive; Polysiloxane type pressure sensitive adhesive characteristic is better but expensive; When general polyacrylate pressure-sensitive is used, need use a large amount of organic solvents, the also not environmental protection of cost height, is used and often causes even damage of skin whiting; Emulsion-type polyacrylate pressure-sensitive is non-stimulated to skin, there is high non-oxidizability, do not need to add antioxidant and stabilizing agent, there is suitable glass transition temperature and good viscosity, can not add plasticizer or the viscosifier of low molecular mass, functional.
Embodiment 3: pharmacodynamic study
1, object of study
Selected objects is all from the Dermatology Outpatient Department patient of Affiliated Hospital of Yangzhou University, totally 63 routine Chinese herbs paste treatment group 31 examples (1 example comes off), matched group 32 examples (1 example comes off).Allly enter to organize patient and all sign and write notice in the know.
2, diagnostic criteria
Skin cypridology with reference to People's Health Publisher's publication in 2008:
(1) before dermexanthesis, there is the slightly General Symptoms such as weak, low grade fever, poor appetite;
(2) the conscious scorching hot or causalgia of illing skin, that touches has an obvious Hyperalgesia;
(3) predilection site is intercostal nerves, cervical nerves, y-bend nerve and waist bones of the body innervation region;
(4) there is flushing speckle in skin lesion Chang Shouxian, occurs that very soon foxtail millet grain is to Semen Glycines size pimple, and bunch shape distributes and do not merge, and then becomes rapidly water scar, and cellulitis wall is thin, the clarification of lump liquid;
(5) skin lesion is banded arrangement along a certain peripheral nerve, mostly occurs in a side of health, is generally no more than
Median line;
(6) course of disease is general 2 one 3 weeks, and old people is 3 one 4 weeks, and water cellulitis is dry, knot is silly leaves temporary light red speckle or pigmentation after coming off:
(7) still can there be the Special Manifestations such as an indomethacin, ear indomethacin "
3, Therapeutic Method
Two groups of methods that all adopt Experience of Combined Treatment of Internal Medicine to add (comprising quiet antiviral drugs acyclovir, oral pain alleviating agent, the aggregate measures such as intramuscular injection trophic nerve medicine vitamin B1, mecobalamin) topical therapeutic.Matched group is used acyclovir ointment external, and smear affected part 4-5 every day.Chinese herbs paste treatment group of the present invention is pressed skin lesion size and is used, and every 7 days was 1 course for the treatment of, and according to the state of an illness, continuous 2 courses for the treatment of, if lesions of patients disappears, pain disappears, and both can stop Chinese herbs paste.If local skin lesion water scar) ICm, feasible scar liquid extracts postoperative, then external application medicine.During treatment, prohibit and drink, avoid edible pungent! Stimulate food, avoid the skin lesion place mechanical irritation such as scratch, in order to avoid the observation that affects the treatment " within 1 week, be 1 course for the treatment of, Continuous Observation 2 weeks, patient, in further consultation in the 7th, 14 days, observes and notes down index.At the 30th day, follow up a case by regular visits to patient, whether record there is post herpetic neuralgia, and the number of cases of record appearance.
4, efficacy evaluation
Skin lesion observation index
(1) skin lesion area:
According to version < < new Chinese medicine guideline of clinical investigations > > in 2002 and pertinent literature
0 minute without skin lesion
1 minute skin lesion area <50cm2
3 minutes skin lesion area 50emZ mono-99Cm2
5 minutes skin lesion areas) 100cm2
(2) erythema:
0 minute without erythema
1 minute light red speckle
2 minutes edema type erythema
3 minutes scarlet speckles of edema type
4 minutes purplish-red maculas
(3) water cellulitis
O divides anhydrous scar
1 minute Mild edema or water scar subside, tie silly
2 are dispersed in needle point to foxtail millet grain Taegu scar rash
3 minutes intensive mound skin ulcer rash, water lump
4 minutes pus lumps, blood cellulitis or large cellulitis
Observation of pain index
Adopt 6 behavior scoring methods (BRS 1), according to banded lump rash pain feature, be divided into six grades:
0 minute without pain
Within 1 minute, there is pain, but can be ignored easily
Within 2 minutes, there is pain to ignore, affect daily life
Within 3 minutes, there is pain, cannot ignore disturbance of concentration
4 minute daytime, pain cannot be ignored, disturbance of concentration, impact sleep that night, the pain increased
Existence in 5 minutes has an intense pain, and affects daily life and sleep
The standard of curative effect evaluation
Adopt nimodipine method, curative effect judging standard is divided into recovery from illness, effective, effective, invalid 4 grades "
(1) recovery from illness: recovery from illness :≤90% deflorescence, clinical sign disappears without pain, does not stay any sequela,
Therapeutic index >=90%
(2) effective :≤70% skin lesion disappears, and pain obviously alleviates, therapeutic index > 60%, <90%
(3) effective: the skin lesion %30% that disappears, <70%, pain relief,
(4) invalid: the skin lesion <30% that disappears, pain is without obviously alleviating, therapeutic index <30%
Therapeutic index <30%
5, result of study
Case enters to organize condition
This research is included altogether 63 routine Patients with Herpes Zosters in and is entered clinical trial, treatment group 31 examples after random packet, and 30 examples complete total Test, and 1 example comes off; Matched group 32 examples, 31 examples complete total Test, and 1 example comes off.Have 62 examples and meet scheme.Treatment group 1 example is because running counter to therapeutic scheme, and by the processing that comes off, matched group 1 example is because of working principle therapy discontinued, also by the processing that comes off.
Two groups relatively harmonious
From sex treatment group 31 examples, male's 16 examples wherein, women's 15 examples; Matched group 30 examples, male's 17 examples wherein, women's 14 examples.Through X 2 test, two groups of Genders compare χ
2=0.127, P=0.810, P>0.05.
Two groups of patient ages distribute relatively, treatment group 31 examples, 18～44 years old 12 example, 45～60 years old 13 example, 61～75 years old 6 example, mean age
matched group 30 examples, 18～44 years old 14 example, 45～60 years old 11 example, 61～75 years old 5 example, matched group mean age
through independent sample t check, statistic t=0.064, P=0.891, P>0.05.
The comparison of two groups of patient's courses of disease, treatment group 31 examples, 1～3 day 20 example, 4～5 days 11 examples, average course of disease 3.25 days; Matched group 30 examples, 1～3 day 21 example, 4～5 days 9 examples, average course of disease 3.13 days.Through X 2 test, two groups of patient's statistic χ
2=0.473, P=0.613, P>0.05.
The comparison of two groups of patient's site of pathological change, treatment group 31 examples, site of pathological change is 5 examples, 8 examples of breast side of body portion, 14 examples of waist and belly, buttocks lower limb portion 4 examples of shoulder neck upper limb portion; Matched group 30 examples, site of pathological change is 4 examples, 9 examples of breast side of body portion, 12 examples of waist and belly, buttocks lower limb portion 5 examples of shoulder neck upper limb portion.Through X 2 test, two groups of patient's statistic χ
2=0.757, P=0.823, P>0.05.
Two groups of patient's diseases quantize total mark comparison, treatment group 31 examples,
matched group 30 examples,
through independent sample t check, statistic t=0.216, P=0.753, P>0.05.
7, efficacy analysis
Two groups of lesions of patients integral contrasts
From table, 1-2 can find out, aspect skin lesion disappears, two groups of patients after treatment, after treatment the 1st, 11,14 days of two groups of patients, difference not statistically significant, and after treatment the 2nd, 3,4,7,9 days, treatment group is better than matched group.
After table 1 liang group patient treatment, the skin lesion integration of first week changes relatively
After table 2 liang group patient treatment, the skin lesion integration of second week changes relatively
Through t check in groups, treatment is the 1st, 11,14 days two groups of equal >0.05 of comparison P afterwards; Latter the 2nd, 3,4,7,9 days for the treatment of, the equal <0.05 of comparison P of two groups of integrations
Relatively rear with treatment before treatment group treatment, t=23.103, P<0.001, before and after treatment, difference has statistical significance; Before treatment of control group with after treatment, compare, t=20.107, P<0.001, before and after treatment, difference has statistical significance.
Two groups of patient's pain integral contrasts
From table, 3-4 can find out, aspect pain relief, and two groups of patients after treatment the 1st, 9,11,14 days, zero difference, and after treatment the 2nd, 3,4,7 days, treatment group is better than matched group.
After table 3 liang group patient treatment, first week pain integration changes relatively
After table 4 liang group patient treatment, second week pain integration changes relatively
Through t check in groups, latter the 1st, 9,11,14 days for the treatment of, two groups are compared the equal >0.05 of P; Latter the 2nd, 3,4,7 days for the treatment of, the equal <0.05 of P of two groups of comparisons
Relatively rear with treatment before treatment group treatment, t=20.386, P<0.001, before and after treatment, difference has statistical significance; Before treatment of control group with after treatment, compare, t=22.013, P<0.001, before and after treatment, difference has statistical significance.
The comparison of transference cure time
As can be seen from Table 5, only on bleb time, incrustation time, decrustation time, comparing, two groups are compared zero difference, and on erythema regression time, analgesic time and pain disappearing time, treatment group is better than matched group.
The table 5 liang group transference cure time (my god) relatively
Through t check in groups, two groups are stopped bleb time, incrustation time, the comparison of decrustation time, the equal >0.05 of P value; And two groups of erythema regression times, analgesic time, pain disappearing time comparison, the equal <0.05 of P value
Medicine for external use treatment time comparison
As can be seen from Table 6, two groups of patient's medicine for external use treatment time zero differences.
Table 6 liang group patient's medicine for external use time (my god) relatively
Through non parametric tests, two groups of external used medicine time comparisons, statistic χ
2=0.673, P=0.723, P>0.05
General curative effect comparison
As can be seen from Table 7, two groups of patients are all effective in cure, and between two groups at the difference not statistically significant of cure rate, total obvious effective rate and total effective rate.
Table 7 liang group general curative effect comparison
Through nonparametric Mann-Whitney U check, statistic Z=-0.765, P=0.426, P>0.05
There is post herpetic neuralgia situation analysis in patient
Latter the 30th day for the treatment of, there is post herpetic neuralgia situation relatively in Table 8 in two groups of patients.Wherein treatment group has 1 example that post herpetic neuralgia occurs, and accounts for 3.45% of total effectively number of cases; Matched group has 2 examples that post herpetic neuralgia occurs, and accounts for 7.41% of total effectively number of cases.The incidence rate zero difference of two groups of post herpetic neuralgias.
After table 8 liang group patient treatment, there is the comparison of post herpetic neuralgia situation
Through X 2 test, χ
2=0.413, P=0.507, P>0.05.
Claims (2)
1. treat a Chinese medicine Ethosomal gel patch for herpes zoster, it is characterized in that this patch curative effect composition is Chinese medicine composition, pressure sensitive adhesive is emulsion-type polyacrylate; Described Chinese medicine composition counts by weight percentage, by glycyrol plastid 30%, and Radix Gentianae, the Radix Paeoniae Alba, Radix Bupleuri, Radix Angelicae Sinensis, the Radix Rehmanniae, Rhizoma Chuanxiong, the mixed decocting liquid 60% of Fructus Toosendan water, polyvinyl alcohol 2%, Fructus Gardeniae 1%, Olibanum 3%, Indigo Naturalis 1%, Borneolum Syntheticum 3% formula forms.
2. prepare a method for the treatment of the Chinese medicine Ethosomal gel patch of herpes zoster described in claim 1, it is characterized in that comprising the following steps:
(1) take as required Radix Glycyrrhizae, pulverize, by Radix Glycyrrhizae weighing scale, add 10 times of amount 30% ethanol, add ammonia and adjust pH8.5～9.5, in 80 ℃～90 ℃ backflow 2h, with three layers of gauze, leach medicinal residues immediately, filtrate while hot reclaim ethanol after 0.45 μ m filter membrane and obtain water liquid 1; 30% ethanol that adds 8 times of amounts of Radix Glycyrrhizae weight to medicinal residues, adds ammonia and adjusts pH8.5～9.5, in 80 ℃～90 ℃ backflow 1h, leaches medicinal residues immediately with three layers of gauze, and filtrate is reclaimed ethanol after mistake 0.45 μ m filter membrane while hot and obtained water liquid 2; Merge water liquid 1 and water liquid 2, vacuum concentration is to glycyrrhizic acid content >=50%, moisture 15%～30%, and all the other be glycyrrhizic acid Radix Glycyrrhizae extract in addition, so obtain concentrated Radix Glycyrrhizae extract;
(2) by concentrated Gan grass Ti Qu Wu ︰ great beans Lin Zhi ︰ Dan Gu Chun ︰ dehydrated alcohol, be the weight ratio of 1 ︰ 4 ︰ 0.03 ︰ 60, first dehydrated alcohol is added in the mixture of soybean phospholipid and cholesterol, after stirring and dissolving, add concentrated Radix Glycyrrhizae extract, and with high speed dispersion homogenizer 3000r/min homogenizing 1min, then within 10 minutes, obtain glycyrol plastid through high pressure homogenizer room temperature homogenizing;
(3) take respectively Radix Gentianae, the Radix Paeoniae Alba, Radix Bupleuri, Radix Angelicae Sinensis, the Radix Rehmanniae, Rhizoma Chuanxiong, the Fructus Toosendan of 1/5 Radix Glycyrrhizae amount, 10 times of weight water 1h that add mixed powder after mixing coarse pulverization successively decoct twice, merge decoction liquor, cross while hot 0.45 μ m filter membrane final vacuum and be concentrated into Chinese medicine composition formula ratio, the polyvinyl alcohol that adds Chinese medicine composition formula ratio, makes its natural swelling dissolve to obtain Chinese medicine hydrogel;
(4) take respectively Fructus Gardeniae, Olibanum, Indigo Naturalis, the Borneolum Syntheticum of Chinese medicine composition formula ratio, mix, micronizing obtains nanoscale Chinese medicine powder;
(5) glycyrol plastid is added in Chinese medicine hydrogel, be sprinkled into while stirring nanoscale Chinese medicine powder, with high speed dispersion homogenizer 3000r/min homogenizing 1min, then within 10 minutes, obtain Chinese medicine composition through high pressure homogenizer room temperature homogenizing;
(6) at separate paper bottom, be evenly coated with emulsion-type polyacrylate, Chinese medicine composition is evenly coated in middle level, and upper strata is evenly coated with emulsion-type polyacrylate again, covers stretch fabric, cuts into prescribed level sealing and preserves.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105311417A (en) * | 2015-12-02 | 2016-02-10 | 卢雨萍 | Externally applied traditional Chinese medicine for treating herpes zoster |
| CN117618400A (en) * | 2023-11-29 | 2024-03-01 | 北京烨桦疑难病中医研究院 | Composite traditional Chinese medicine mist absorbing preparation for improving immunity and preparation method thereof |
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| CN117618400A (en) * | 2023-11-29 | 2024-03-01 | 北京烨桦疑难病中医研究院 | Composite traditional Chinese medicine mist absorbing preparation for improving immunity and preparation method thereof |
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| CN103536700B (en) | 2015-04-22 |
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