CN103520448A - Traditional Chinese medicinal composition for treating chronic atrophic gastritis - Google Patents

Abstract

The invention discloses a traditional Chinese medicinal composition for treating chronic atrophic gastritis. The chronic atrophic gastritis belongs to categories of epigastric pains, fullness and noises, has complex disease causes and mechanisms, is commonly caused by improper diet, emotional anxiety, incoordination between the liver and the spleen, vitality consumption and body fluid impairment, and stomach nutrition loss, and stomach channel stasis can be caused after long-term chronic atrophic gastritis. The pathogenesis basis of the chronic atrophic gastritis is spleen and stomach weakness, and the pathology key is extravasated blood interface resistance, so Kadsura japonica, liquid distilled from clove, Chinese Taxillus Twig, Solanum lyratum Thunb, Murraya exotica L., Herb of Gold Stargrass, vine of Chinese magnoliavine, Vaccaria segetalis, Root of Tuan Linden, root of Sandhill Tylophora, garlic, Trlophora yunnanensis Schitr and licorice are decocted to form a decoction which can be orally taken. Clinic observation shows that the traditional Chinese medicinal composition has a total effective rate reaching 96.30% and has no obvious toxic side effects.

Description

A kind of Chinese medicine composition for the treatment of chronic atrophic gastritis

Technical field

The present invention relates to a kind of Chinese medicine composition, relate in particular to a kind of Chinese medicine composition for the treatment of chronic atrophic gastritis.

Background technology

Chronic atrophic gastritis (CAG) is that a kind of to take that gastric mucosa atrophy attenuation, intrinsic body of gland reduce or disappear be the digestive system commonly encountered diseases of feature, often with intestinal epithelial metaplasia and atypical hyperplasia, account for gastroscope and examined the 20%-45% of case, with being related closely of gastric cancer.Doctor trained in Western medicine there is no specific treatment at present.I find through clinical observation for many years, utilize treatment by Chinese herbs chronic atrophic gastritis to have good curative effect.

Summary of the invention

The object of this invention is to provide a kind of Chinese medicine composition for the treatment of chronic atrophic gastritis.The traditional Chinese medical science thinks, the chronic atrophic gastritis cause of disease is complicated, is mainly the many factors combineds effect such as eating and drinking without temperance, feelings will internal injury, overstrain, innate deficiency, emptiness of spleen and stomach, impairing the spleen and stomach, and taste imbalance, stomach network is become estranged, and QI-blood circulation is not smooth, congestion resistance network.

The object of the invention is to be achieved through the following technical solutions, the Chinese medicine composition of this treatment chronic atrophic gastritis is made by the Chinese medicine of following weight portion: Liquor Caryophylli 20-30 part, Radix Kadsurae longipedunculatae 15-25 part, Herba Taxilli 4-6 part, Herba Solani Lyrati 10-15 part, Folium Et Cacumen Murrayae 8-14 part, Herba hypoxis aureae 5-7 part, Caulis seu Radix Schisandrae Henryi 7-9 part, Herba Melandrii Aprici 30-35 part, Radix Tiliae 7-12 part, Radix Tylophorae arenicolae 4-7 part, Bulbus Allii 10-14 part, Radix Paeoniae Alba 6-10 part, Radix Tylophorae Yunnanensis 7-9 part, Radix Glycyrrhizae 4-6 part.

Preferred: 25 parts of Liquor Caryophyllies, 20 parts of Radix Kadsurae longipedunculataes, 5 parts of Herba Taxillis, 13 parts of Herba Solani Lyratis, 11 parts of Folium Et Cacumen Murrayae, 6 parts of Herba hypoxis aureae, 8 parts of Caulis seu Radix Schisandrae Henryi, 32 parts of Herba Melandrii Aprici, 9 parts of Radix Tiliaes, 6 parts of Radix Tylophorae arenicolaes, 12 parts, Bulbus Allii, 10 parts of the Radix Paeoniae Albas, 8 parts of Radix Tylophorae Yunnanensis, 5 parts, Radix Glycyrrhizae.

Preparation method: make decoction by traditional preparation method decocting.

In side: Liquor Caryophylli: stomach warming pain relieving; Caulis seu Radix Schisandrae Henryi: the repercussive that nourishes blood, regulating QI to expel dampness; Radix Kadsurae longipedunculatae, Folium Et Cacumen Murrayae: promoting the circulation of QI to relieve pain, promoting blood circulation to remove blood stasis; Herba Melandrii Aprici: invigorate blood circulation, loose long-pending spleen invigorating; Radix Tiliae: dispel the wind, invigorate blood circulation, analgesia; Radix Tylophorae Yunnanensis: promoting blood circulation and stopping pain, tonifying speen and tonifying kidney; Herba hypoxis aureae: the kidney warming regulating QI; Herba Taxilli: invigorating the liver and kidney, beneficial blood vessels; Radix Tylophorae arenicolae: the kidney invigorating, spleen invigorating, removing toxic substances; Herba Solani Lyrati: removing toxic substances and promoting subsidence of swelling, anticancer; Bulbus Allii: the stagnant removing food stagnancy of row, removing toxic substances spleen invigorating, anti-cancer and cancer-preventing, antibacterial; The Radix Paeoniae Alba: the easing the affected liver of enriching blood, suppressing the hyperactive liver pain relieving, antiinflammatory are antibacterial; Radix Glycyrrhizae: in QI invigorating benefit, coordinating the actions of various ingredients in a prescription

Clinical data

1. physical data is collected in January, 2011-2012 gastroscope in year January and pathological biopsy is diagnosed as CAG patient's totally 54 examples, is divided at random treatment group 27 examples, outpatient service 11 examples, 16 examples of being in hospital, man's 16 examples, female's 11 examples, 37～77 years old age, average 52.6 years old, the course of disease 2.6～25 years, average 16.8 years; Positive 12 examples of HP.Matched group 27 examples, outpatient service 13 examples, 14 examples of being in hospital, male 15 examples, female's 12 examples, 34～76 years old age, average 47.3 years old, the course of disease 2.5～22 years, average 15.8 years; Positive 10 examples of HP.Physical data no difference of science of statistics, has comparability

2. diagnostic criteria: all patients all row gastroscopy make a definite diagnosis, meet " chronic atrophic gastritis Chinese traditional medical diagnose National Consensus (2009, Shenzhen) " in about the Chinese and western medicine diagnostic criteria of CAG, and all patients all have gastralgia, poor appetite, feeling of fullness, noise burns, hungry and do not eat, time have nauseating xerostomia, the symptom such as be hard and dry.Under gastroscope, visible gastric mucosa color is thin out, be light red, sallow, severe one is greyish white or dusty blue, and under mucosa, blood vessel is remarkable, and mucosal fold is tiny even to disappear, when atrophic gastritis is during with body of gland cervical region hyperplasia or intestinal epithelial metaplasia, the coarse injustice of mucomembranous surface, is graininess or nodositas, and atrophy mucosa fragility increases, easily hemorrhage, and can have rotten to the corn kitchen range.Physical data no difference of science of statistics, has comparability.

3. two groups of patients of Therapeutic Method all give the general treatments such as routine care, Diet Therapy, matched group gives conventional Western medicine oral medication on general treatment basis: 1. esomeprazole enteric coatel tablets (AstraZeneca pharmaceutical Co. Ltd, the accurate word H20046379 of traditional Chinese medicines), 20mg/ time, 2 times/d; 2. Hp positive: Amoxicillin Capsules (Lukang Medical Co., Ltd., Shandong, the accurate word H37020581 of traditional Chinese medicines), 1g/ time, 2 times/d; Treatment group adds in order to upper Chinese medicine composition (Liquor Caryophylli 25g, Radix Kadsurae longipedunculatae 20g, Herba Taxilli 5g, Herba Solani Lyrati 13g, Folium Et Cacumen Murrayae 11g, Herba hypoxis aureae 6g, Caulis seu Radix Schisandrae Henryi 8g, Herba Melandrii Aprici 32g, Radix Tiliae 9g, Radix Tylophorae arenicolae 6g, Bulbus Allii 12g, Radix Paeoniae Alba 10g, Radix Tylophorae Yunnanensis 8g, Radix Glycyrrhizae 5g), every day potion, sooner or later sub-service of decocting 400ml.It 2 weeks is 1 course for the treatment of that two groups of patients all treat continuously, finishes two groups of curative effects of rear contrast and untoward reaction 2 courses for the treatment of.

2. criterion of therapeutical effect is formulated criterion of therapeutical effect according to the treatment Patients Before And After state of an illness with reference to scholar's research such as Wang Xuewu: recovery from illness: symptom, sign disappear completely, and gastroscope shows that focus is clearly better, and pathologic finding shows abnormal disappearance, and Hp is negative; Effective: cardinal symptom, sign disappear, gastroscope shows that focus takes a turn for the better, and pathologic finding shows abnormal disappearance or alleviate 2 ranks, and Hp is negative or alleviate; Effective: symptom, sign obviously alleviate, gastroscope shows that focus take a turn for the better to surpass half, and pathologic finding shows and extremely alleviate 1 rank, and Hp alleviates; Invalid: not reach effective minimum standards.Recovery from illness, effective and effective sum are effectively total.

3. two groups of patients of therapeutic outcome all treated after 2 courses for the treatment of, and treatment group total effective rate 96.30% is better than 81.48% of matched group, and difference has statistical significance (P < 0.05), and concrete Comparison of therapeutic data are in Table 1.

Table 1 liang group Comparison of therapeutic

6. untoward reaction: have 5 routine patients to occur erythra during treatment of control group, 6 routine patient's fatigue and weakness.There is erythra in treatment group 2 examples.

The specific embodiment

Embodiment mono-: take Liquor Caryophylli 25g, Radix Kadsurae longipedunculatae 20g, Herba Taxilli 5g, Herba Solani Lyrati 13g, Folium Et Cacumen Murrayae 11g, Herba hypoxis aureae 6g, Caulis seu Radix Schisandrae Henryi 8g, Herba Melandrii Aprici 32g, Radix Tiliae 9g, Radix Tylophorae arenicolae 6g, Bulbus Allii 12g, Radix Paeoniae Alba 10g, Radix Tylophorae Yunnanensis 8g, Radix Glycyrrhizae 5g, by traditional preparation method decocting, make decoction.

Embodiment bis-: take Liquor Caryophylli 30g, Radix Kadsurae longipedunculatae 25g, Herba Taxilli 4g, Herba Solani Lyrati 10g, Folium Et Cacumen Murrayae 14g, Herba hypoxis aureae 5g, Caulis seu Radix Schisandrae Henryi 9g, Herba Melandrii Aprici 35g, Radix Tiliae 12g, Radix Tylophorae arenicolae 4g, Bulbus Allii 10g, Radix Paeoniae Alba 6g, Radix Tylophorae Yunnanensis 9g, Radix Glycyrrhizae 6g, by traditional preparation method decocting, make decoction.

Embodiment tri-: take Liquor Caryophylli 20g, Radix Kadsurae longipedunculatae 15g, Herba Taxilli 6g, Herba Solani Lyrati 15g, Folium Et Cacumen Murrayae 8g, Herba hypoxis aureae 7g, Caulis seu Radix Schisandrae Henryi 7g, Herba Melandrii Aprici 30g, Radix Tiliae 7g, Radix Tylophorae arenicolae 7g, Bulbus Allii 14g, Radix Paeoniae Alba 10g, Radix Tylophorae Yunnanensis 7g, Radix Glycyrrhizae 4g, by traditional preparation method decocting, make decoction.

Claims (2)

1. treat a Chinese medicine composition for chronic atrophic gastritis, it is characterized in that this Chinese medicine composition made by the Chinese medicine of following weight portion: Radix Kadsurae longipedunculatae 7-9 part, Liquor Caryophylli 4-8 part, Herba Taxilli 4-6 part, Herba Solani Lyrati 3-6 part, Folium Et Cacumen Murrayae 7-9 part, Herba hypoxis aureae 5-7 part, Caulis seu Radix Schisandrae Henryi 4-6 part, Herba Melandrii Aprici 7-9 part, Radix Tiliae 7-12 part, Radix Tylophorae arenicolae 4-7 part, Bulbus Allii 10-14 part, Radix Paeoniae Alba 6-10 part, Radix Tylophorae Yunnanensis 7-9 part, Radix Glycyrrhizae 6-8 part.

2. a kind of Chinese medicine composition for the treatment of chronic atrophic gastritis according to claim 1, is characterized in that this Chinese medicine composition made by the Chinese medicine of following weight portion: 8 parts of Radix Kadsurae longipedunculataes, 6 parts of Liquor Caryophyllies, 5 parts of Herba Taxillis, 4.5 parts of Herba Solani Lyratis, 8 parts of Folium Et Cacumen Murrayae, 6 parts of Herba hypoxis aureae, 5 parts of Caulis seu Radix Schisandrae Henryi, 8 parts of Herba Melandrii Aprici, 9.5 parts of Radix Tiliaes, 5.5 parts of Radix Tylophorae arenicolaes, 12 parts, Bulbus Allii, 8 parts of the Radix Paeoniae Albas, 8 parts of Radix Tylophorae Yunnanensis, 7 parts, Radix Glycyrrhizae.