CN103497871A - Formulation method for blood-nourishing yin-nourishing health-care wine - Google Patents
Formulation method for blood-nourishing yin-nourishing health-care wine Download PDFInfo
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Abstract
A formulation method for blood-nourishing yin-nourishing health-care wine. The combined formula is prepared from the following raw materials by mass: 10-20 parts of radix angelicae, 12-20 parts of cinnamon, 12-18 parts of polygonatum rhizome, 10-18 parts of white poria, 3-7 parts of white chrysanthemum, 1700-2200 parts of liquor, 7-12 parts of white peony roots, and 8-13 parts of angelica; the raw materials are carefully chosen, cleaned, cut into slices, put into a tank, and immersed with liquor; after immersion, herb residues are filtered; the filtered liquor is blended with honey or white sugar, and then filtered again; the filtered wine is loaded, inspected, and packaged into finished products. The health-care wine is suitable for population with various physiques, can nourish yin, benefit qi, promote the production of body fluid to quench thirst, improve immunity, promote metabolism, and especially has the function of adjusting body functions of population with qi deficiency or anemia; the method of the invention is simple in preparation process, low in cost, and can be implemented by manufacturers with wine production conditions.
Description
Affiliated technical field
The present invention relates to a kind of compound formulation of health promoting wine, especially a kind ofly can nourish blood, the compound formulation of Yin enriching heath care wine.
Background technology
At present, along with growth in the living standard, pursue healthy health promoting wine as a brand-new noun, just progressively come into people's life.Health promoting wine, as its name suggests, just refer to and drink the rear and wine that can play a role in health care nutritious to human body.The former general designation medicinal liquor of health promoting wine, be the branch of traditional medicinal liquor, is the extension of common white spirit.The history of existing thousands of years is the important component part of Chinese Medicine science.In the successive dynasties medicine works of China, almost there is bar none medicinal liquor to control the record of disease body-building.Today is along with scientific and technical progress, from the basis of the traditional technology of Chinese medicine infusing drugs in wine, developed into modernization meanses such as utilizing extraction, lixiviate and biotechnology, extracts the function type health care wine that effective ingredient in Chinese medicine is made high-content.
Summary of the invention
The purpose of this invention is to provide a kind ofly nourish blood, the compound formulation of Yin enriching heath care wine, this formula can enriching yin boost qi, promote the production of body fluid to quench thirst, and improves immunizing power, enhances metabolism.
Combination formula of the present invention is selected as follows according to the quality proportioning:
Root of Dahurain angelica 10-20 part, Chinese cassia tree 12-20 part, sealwort 12-18 part, white tuckahoe 10-18 part, Flos Chrysanthemi 3-7 part, white wine 1700-2200 part, root of herbaceous peony 7-12 part, Radix Angelicae Sinensis 8-13 part.
Best of breed formula of the present invention is selected as 16 parts of the roots of Dahurain angelica, 14 parts of Chinese cassia trees, 15 parts of sealworts, 16 parts of white tuckahoes, 4 parts of Flos Chrysanthemis, 1900 parts of white wine, 9 parts of the root of herbaceous peonys, 11 parts of Radix Angelicae Sinensis according to the quality proportioning; By after picking of raw material, clean, cut into slices, then be placed in tank and add soaking in Chinese liquor, filter out the dregs of a decoction after soaking, the wine filtered out is allocated with honey or white sugar, enter again and filter, filling, to test, packing becomes finished product.
The root of Dahurain angelica: wind-damp dispelling, the apocenosis of invigorating blood circulation, myogenic pain relieving.
Health-care effect:
1. beauty functions: expel pathogenic wind from the body surface, dispersing cold for relieving pain, dehumidifying are sensible, detumescence and apocenosis.Can improve microcirculation in human body, promote skin metabolism, eliminate pigment and excessively pile up in tissue, remove the facial colour spot scar, treatment skin blister wound mange etc.Shennong's Herbal is pointed out the root of Dahurain angelica: " longue skin.Moist color, can make face fat." no matter be " a thousand pieces of gold face fat side ", or the Empress Dowager's the empirical formula of preserving youthful looks " beautiful face is loose ", the root of Dahurain angelica is all the main ingredient of making face fat.Be referred to as to go facial blackspot.The modern medicine proof root of Dahurain angelica has certain curative effect to acne, blackhead, acne, at whitening and speckle dispelling, improves microcirculation, and there is unique curative effect the delay skin aging aspect.
2. anti-inflammatory action: the mouse stomach root of Dahurain angelica or Radix angelicae dahuricae decoction (the suitable crude drug 1g of 1g) 4g/kg, can obviously suppress the inflammation (P<0.01) of dimethylbenzene induced mice ear.
3. antipyretic effect: the hot animal model of the height caused in the White Rabbit back with the peptone subcutaneous injection, the 1g root of Dahurain angelica or Radix angelicae dahuricae decoction 15g/kg, have obvious refrigeration function.The mouse stomach root of Dahurain angelica or Radix angelicae dahuricae decoction 8g/kg, obviously reduce the mouse writhing number of times due to abdominal injection 1% acetic acid (0.1/kg), and effect is similar with pyramidon 8mg/kg, P<0.001.Woolfe-Macdonald method test, the front threshold of pain of administration is at 30 minutes with interior person, and gavage awards the root of Dahurain angelica or Radix angelicae dahuricae 8g/kg, and after administration 60 minutes, the root of Dahurain angelica and the anti-root of Dahurain angelica obviously improved threshold of pain, with physiological saline group P<0.001 and 0.01 relatively.
4. spasmolysis: contained bergapton, xanthotoxin, Isoimperatorin second have obvious spasmolysis to the rabbit ileum.Isoimperatorin can also increase the tonus of convergent force and the earthworm flesh of rabbit uterus.Scopoletin has spasmolysis at body or isolated rat hysterospasm due to oestrogenic hormon or bariumchloride, and its ED50 is 0.09mg/kg.
5. anti-microbial effect: root of Dahurain angelica decoction all has restraining effect to intestinal bacteria, dysentery bacterium, Bacillus proteus, Corynebacterium diphtheriae, paratyphosum Bacterium, Pseudomonas aeruginosa, vibrio cholerae, Bacillus tuberculosis etc.The contained Oxypeucedannin in vitro tests of these product has anti-microbial effect to 11 kinds of bacterial strains; Pentosalen also has the anti-microbial effect xanthotoxin; MIC to Bacillus tuberculosis H37RV is 100mcg/ml.The water logging agent also has certain restraining effect to pathomycetes such as Microsporon audouinis.
6. photosensitization: contained bergapten, xanthotoxin, the Isoimperatorin the second grade furocoumarin compound of these product is optical active substance, after they enter body, once be subject to daylight or uviolizing, can make exposure place skin generation sunburn, generation is red and swollen, pigment increases, plain skin thickens etc.Photosensitive activity is with xanthotoxin for the strongest, and bergapten takes second place, Isoimperatorin second a little less than.The photosensitive activity material can be used to treat vitiligo.Isoimperatorin is the psoriatic effective constituent for the treatment of, clinical effective by erythema dose mensuration proof.
7. antitumous effect: Isoimperatorin and there is the cytotoxicity to the Hela cell from Sodium Ferulate.The ED50 100 μ g/ml of Isoimperatorin.
8. radiation resistance: root of Dahurain angelica methanol extract 1g/kg is in first 5 minutes abdominal injections of roentgen radiation x, and to mouse skin, infringement has protective effect.
Chinese cassia tree: cure mainly insufficiency of kidney-YANG; Gate of vitality's fire aversion to cold and cold limbs; Soreness of the waist and knees; Impotence and seminal emission; Dysuria or frequency; The syndrome characterized by dyspnea of losing heart; The all cards of edema oliguria; Decline of the fire from the gate of life; Fire is Gui Yuan not; Floating yang; Refusing yang; And heat in the upper and cold in the lower; The flushing foot is cold; Dizziness and tinnitus; Dispute is rotten broken; Spleen is suffered from a deficiency of the kidney cold; Coldness and pain in the epigastrium; Food subtracts loose stool; Lumbago due to renal deficiency; Arthralgia due to cold-dampnes; Cold hernia pain; Palace is cold infertile; Dysmenorrhoea is through closing; The stagnant stomachache of the stasis of blood in postpartum; Cloudy subcutaneous ulcer streamer; Or cold of insufficiency type large carbuncle purulence does not become to burst; Or do not hold back after bursting.
Sealwort: be used as medicine with rhizome.There is boosting qi and nourishing yin, invigorating the spleen, moistening lung, kidney benefiting functions.Be used for the treatment of weakness of the spleen and the stomach, fatigue and asthenia, dry food is few, deficiency syndrome of the lung cough caused by dryness, asthenia of essence and blood, the interior heat disease such as quench one's thirst.Very effective in cure for diabetes.
Health-care effect:
1. resisting pathogenic microbes effect: in vitro tests shows, sealwort water extraction fluid (1: 320) has restraining effect to Corynebacterium diphtheriae, streptococcus aureus, acid-fast bacilli, and 2% sealwort has restraining effect in various degree to common pathomycete in sabouraud culture medium.
2. on the impact of blood sugar: rabbit gavage sealwort medicinal extract, its blood-sugar content increases gradually, then reduces.The blood sugar that sealwort medicinal extract causes suprarenin is too high is remarkable restraining effect.
3. antifatigue effect: sealwort decoction 17.67% a concentration 0.3ml/ abdominal injection can extend the mouse swimming time.
4. antioxygenation: sealwort decocting liquid 20% concentration, 13ml/ only feeds drink, and continuous 27 days, make that mouse liver superoxide-dismutase (SOD) is active to raise, myocardium lipofuscin content reduces.
5. delaying senility function: the sealwort decoction, 20% concentration is soaked mulberry leaf and is fed silkworm, and the effect that extends the silkworm larva phase is arranged.
6. anastalsis: sealwort methanol extract 40mg/ only, propyl carbinol part 20mg/ only, water layer part 20mg/ only, abdominal injection, to the freezing mouse tail of dry ice-methyl alcohol 1 minute, the experiment of back-end crop method showed that anastalsis is arranged, and the mouse amount of bleeding is reduced.
7. to Cardiovascular: sealwort aqueous extract 0.16-0.26g/kg intravenous injection obviously increases the anesthetized dog coronary flow; 1.5g/kg intravenous injection, the rabbit myocardial ischemia that Pituitrin is caused has antagonistic action, and the T ripple that the antagonism Pituitrin causes increases, and promotes the T ripple to recover extremely in advance; The 12g/kg abdominal injection, can strengthen the tolerance of mouse to anoxic.
8. antivirus action: 0.2% drop eye of polygonatum polysaccharide, 6 times/days, or add polygonatum polysaccharide 10mg/kg, 2 times/days, the experimental herpes simplex keratitis of rabbit is all had to therapeutic action.
White tuckahoe: ancients claim that Poria cocos is " god medicine " at 4 o'clock, because its effect is very extensive, regardless of the four seasons, by it and various compatibility of drugs, no matter cold, temperature, wind, all diseases that wets can be brought into play its unique effects.Poria cocos flavor is sweet, light, property flat, be used as medicine there is promoting diuresis to eliminate damp pathogen, the function of beneficial spleen and stomach, tranquillizing by calming the heart.Modern medicine study: Poria cocos energy enhancing body immunologic function, Pachymose has significantly antitumor and protect the liver dirty effect.But cold of insufficiency type essence is sliding or collapse from qi deficiency person avoids clothes.
Health-care effect:
1. diuretic properties: by 70% alcohol cold soaking for the Poria cocos crude drug, will soak to obtain the vaporized alcohol of liquid during use, the adding distil water dilution, to finite concentration, then select Healthy Rabbits to press the body weight drug administration by injection, and the chronic experiment result shows, after medication, the urine amount is significantly increased.
2. anti-microbial effect: 100% decoction of Poria cocos all has restraining effect by the flat board method that burrows to streptococcus aureus, intestinal bacteria, Bacillus proteus etc.Poria cocos is without bacteriostatic action to the bacteriostatic test result with test tube method.The ethanol extraction of Poria cocos can kill Leptospira in vitro, but decocting liquid is invalid.
3. on the impact of Digestive tract: Poria cocos has direct relexation to family's rabbits infestines, the formed ulcer of rat pylorus ligation is had to preventive effect, and can fall hydrochloric acid in gastric juice.Separately Liver Damage in Rats due to CCl4 is had to significant protective effect, gpt activity is obviously reduced, prevent hepatic necrosis.
4. antitumor action: the main component in Poria cocos is pachyman (Pachyman), and content is very high.Pachyman itself is without anti-tumor activity, if cut off its contained β-(1 → 6) Glucopyranose side chain, become simple β-(1 → 3) glucose glycan [being called pachymaran (Pachymaran)], to the inhibiting rate of murine sarcoma S180, can reach 96.88%.
The Pachymose body has presented strong antitumor action in animal experiment, the sarcoma 180 cell is seeded in to the ICR/JCL mouse subcutaneous, the various Pachymose bodies of abdominal injection after 24 hours, 5mg/kg dosage every day 1 time, be used in conjunction 10 days, puts to death mouse after 5 weeks, cut open and get tumour and weigh, calculate tumour inhibiting rate.Result shows, pachyman fails to present antitumor action, and the Pachymose tumour inhibiting rate is 95%; The carboxymethylpachymaran tumour inhibiting rate is 73%; Hydroxyethyl pachyman-1 tumour inhibiting rate is 9%; Hydroxyethyl pachyman-2 tumour inhibiting rate is 61%; Hydroxyethyl pachyman-3 tumour inhibiting rate is 99%; Hydroxyethyl pachyman-4 tumour inhibiting rate is 100%.The novel methyl Pachymose injection liquid of completing is tested on the ICR/JCL mouse, finds 100mg/kg dosage successive administration 10 days, to tumour U mono-14 inhibiting rates 92.7%.Novel carboxymethylpachymaran mixes rear incubation 4 hours with the ehrlich carcinoma nutrient solution, with platform, expect that blue dyeing observes the mortality ratio of ehrlich's ascite cell (>50% time mean effectively).When novel carboxymethylpachymaran concentration is 0.25% and 0.50%, mortality ratio is respectively 54.7% and 61.7%.Give the inoculation novel carboxymethylpachymaran of the continuous abdominal injection of Ehrlich ascites carcinoma (100mg/kg/ days) 10 days, extend 23.49% than control group lifetime, and ascites volume reduces 71.53%, and the cancer cells sum reduces 139.20%.To mouse peritoneal injection Pachymose 5-200mg/kg. days, continuous 10 days, the above group of 10mg/kg all had obvious restraining effect to S180.The administration of Pachymose body intraperitoneal, obviously suppress the growth of mouse S180 and ED transplantability Subcutaneous tumor, extends to a certain extent the vegetative period of subcutaneous lotus IMC cancer knurl and S180 mouse.Give mouse stomach carboxymethylpachymaran (250mg/kg/ days) 25 days, cervical cancer U mono-14 lungs are shifted obvious restraining effect is arranged.In carrying out the antineoplastic test of Pachymose body, find that the Pachymose body is the same with other polysaccharide body, just can reach strong restraining effect to the transplanted tumor of growth retardation type, and there are following several characteristics:
Optimal dose: the tumor-inhibiting action of Pachymose body is relevant with dosage, and dosage is too high or too low, all can affect its cancer resistant effect, and in the test of groping optimal dose, the result that each scholar obtains is difference to some extent.As (1971) such as Hamuro do the carboxymethylpachymaran inhibition test, adopt 100mg/kg, 50mg/kg, tri-kinds of various dose of 5mg/kg, tumour inhibiting rate is respectively 92.3%, 96.1%, 53.4% as a result, wherein with 50mg/kg dosage the best.Zhao great Ming (1982) does novel carboxymethylpachymaran inhibition test, adopt 500mg/kg, 100mg/kg, 50mg/kg, 25mg/kg dosage to be tested, tumour inhibiting rate is respectively 75.5%, 92.7%, 78.8%, 79.4% as a result, wherein with 100mg/kg dosage the best.Lv Sucheng etc. (1989) take administration by gavage that Pachymose is made into to 250mg/kg/ days, and 500mg/kg/ days, 1000mg/kg/ days three kinds of concentration are tested, and continuous use detects with 250mg/kg/ days dosage the bests in 7 days, the 8th day.
Different way of administration: the various route of administration of Pachymose system, tumor killing effect also is not quite similar.Inhibition test with carboxymethylpachymaran to sarcoma 180, be used in conjunction 10 days to Switzerland's mouse 5mg/kg dosage, and the abdominal injection tumour inhibiting rate is 99.1%; The intramuscular injection tumour inhibiting rate is 96.5%; The intravenous injection tumour inhibiting rate is 99.6%; The subcutaneous injection tumour inhibiting rate is 86.3%; Oral tumour inhibiting rate is 8.8%.
Flos Chrysanthemi: have another name called camomile, Hang Ju, Flos Chrysanthemi, tea chrysanthemum, medicine chrysanthemum.Flos Chrysanthemi includes chrysanthemum glucoside, amino acid, flavonoid and multivitamin and trace element, and Chinese medical research shows, feverfew has nourishing the liver to improve visual acuity, clears away heart-fire, kidney tonifying, invigorating the spleen and regulating the stomach, wet one's whistle, promote the production of body fluid, and adjusts the effect such as blood fat.
Health-care effect:
Through the modern medicine checking, contain active chemical in chrysanthemum, as VITAMIN B4, choline, stachydrine etc., the volatile oil extract from chrysanthemum, contain chrysanthemum ketone, borneol, Bornyl acetate etc.Pharmacological evaluation proves, the feverfew decoction has restraining effect to Song's Shigella flexneri, Bacillus proteus, Corynebacterium diphtheriae, paratyphosum Bacterium, Pseudomonas aeruginosa, intestinal bacteria and vibrio cholerae etc.
Informal dress chrysanthemum decoction, have obvious expansion hat and increase coronary flow heart, can reduce serum sterol and triglyceride, and can step-down prevention stenocardia.Feverfew also can be for tea, and its color is not second to dragon well green tea.Often take, can strengthen the general character of capillary resistance, inhibition capillary vessel, play the anti-inflammatory Tonic Action.The refreshment drink of relieving summer-heat is liked Flos Chrysanthemi is used as by all provinces in south and Hong Kong and Macao.
White wine: by starch or saccharine material, make the wine unstrained spirits or karusen obtains through distillation.Claim again liquor, white spirit, aquavit etc.Vinosity colourless (or micro-Huang) is transparent, and fragrant odour is pure, and entrance is sweet refreshing clean, and ethanol content is higher, through store aging after, have and take the compound fragrant that the ester class is main body.Take bent class, distiller's yeast is saccharifying ferment, utilizes starchiness (saccharic) raw material, through boiling, saccharification, fermentation, distillation, ageing with blend and all kinds of wine that brew forms.
The root of herbaceous peony: nourishing blood to suppress the hyperactive liver, slow middle pain relieving, astringe yin is received sweat.Control chest abdomen pain over the hypochondriac region, rush down dysentery stomachache, spontaneous sweating, fever due to yin deficiency, menoxenia, uterine bleeding, under band.
Health-care effect:
1. to the effect of cardiovascular systems: the root of herbaceous peony has coronary artery dilator, the effect of reducing blood pressure (d-cachou extract and Progallin A have antithrombotic and antiplatelet aggregative activity)
2. liver protection effect: the root of herbaceous peony has obvious provide protection to liver injury due to tetracol phenixin, aflatoxin B1 .D-GalN
3. spasmolysis: the root of herbaceous peony has restraining effect to intestinal tube and stomach in place motion, can significantly resist the uterine contraction that pitocin causes
4. analgesic activity: the root of herbaceous peony can suppress mouse writhing, shouts, the hot plate reaction, and morphine is suppressed to writhing response synergy, and can resist due to Yetrazol and faint from fear
5. anti-microbial effect.
Radix Angelicae Sinensis: enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, relax bowel.For sallow, the dizzy palpitaition of the deficiency of blood, menoxenia, through closing dysmenorrhoea, asthenia cold abdominalgia, the dry constipation of intestines, rheumatic arthralgia, injury from falling down, ulcer sores.
Health-care effect:
1. antiarrhythmic effect.Radix Angelicae Sinensis water extract and ethanol extraction, the many animals irregular pulse that suprarenin, cardiotonic glycoside and bariumchloride etc. are brought out all has the flesh experiment of obvious antagonistic action guinea-pig heart chamber and shows, Radix Angelicae Sinensis ferment extract and injection of sodium ferulate can resist divaside and the irregular pulse of ouabain due to poisoning, make it reversion to normal rhythm; Add fastoperation when giving back the rat rhythm of the heart that the Hindu Datura Flower Hairy Datura Flower that can slow down causes.During the Iv alcohol extract, the anesthetized rat irregular pulse of Aconitine Induced is also had to obvious prophylactic effect (P<0.001).Report is separately arranged, and the im danggui extract, danggui liujin gao can not prevent and treat various irregular pulse due to napelline, and can not resist the irregular pulse due to chloroform, can not improve the Induced Ventricular Fibrillation Threshold In Rabbit value.The luxuriant middle people in 1985 etc. confirm with electrophysiologic studies, the angelol extract is except having very similar quinidine-like action, significant prolongation plateau also, the antiarrhythmic effect of inferring the angelol extract may be the conduction of slowing down, extend effective refractory period, elimination is turned back, and extends plateau, suppresses ectopic rhythm point and the raising polyergic results such as threshold of quivering.Within 1989, true grade of Zhu Yu carried out the research of antiarrhythmic effect to the Radix Angelicae Sinensis total acid in the water-soluble composition of Radix Angelicae Sinensis; result shows that the animal pharmaceuticals type irregular pulse that the Radix Angelicae Sinensis total acid brings out chloroform one suprarenin, napelline, bariumchloride etc. has significant protective effect, its antiarrhythmic effect may with reduce cardiac excitability, to extend myocardium refractory phase relevant.
2. on the impact of coronary flow and oxygen consumption of myocardium.The research of pharmacology teaching and research room of Hubei medical college shows, eumenol has the effect of remarkable expansion isolated guinea pig coronary, increases coronary flow.The expansible coronary artery of FUFANG DANGGUI ZHUSHEYE, increase coronary flow antagonism experimental rabbit myocardial ischemia.Radix Angelicae Sinensis injection because the acute myocardial ischemia that blocking-up branch of coronary artery blood flow causes has the effect of alleviating, only has increase myocardial ischemia effect to the part conscious dogs to the part anesthetized dog.According to another a training Im report, Radix Angelicae Sinensis neutral oil also has obvious provide protection to the experiment myocardial ischemia.
3. reducing blood-fat and anti-experimental character Atherosclerosis.According to the research data of the new medical college in Jiangsu, Radix Angelicae Sinensis powder 1.5g/kg has the reduction blood fat to rat and rabbit experiment hyperlipidemia, and its reducing blood lipid is not due to due to the absorption that hinders cholesterol.Containing the food of 5% Radix Angelicae Sinensis powder and be equivalent to Radix Angelicae Sinensis oil and other extract of this amount, the aortic disease of getting the experimental atherosclerosis big white mouse has certain protective role.The report of General Hospital, Shenyang Military Command shows that FUFANG DANGGUI ZHUSHEYE (Radix Angelicae Sinensis, Ligusticum wallichii, safflower) can strengthen T ripple that anesthetized dog and extrasomatic rabbit heart coronary flow, prevention Pituitrin cause and increases and resist decreased heart rate due to it, reduces Experimental Hyperlipemia blood rabbit triglyceride level.Can also obviously increase coronary heart disease and cerebral arteriosclerosis disease fibrolan activity.
4. anti thrombotic action.The reports such as Xu Lina, Radix Angelicae Sinensis and Sodium Ferulate thereof have obvious anti thrombotic action.Rat experiment shows, Radix Angelicae Sinensis can make the thrombus dry weight significantly reduce, and the thrombus rate of growth descends than control group.Xu person of outstanding talent's report, the Acute ischemic stroke patient is after angelica for treating, and viscosity of blood reduces, and plasma fibrinogen reduces, prolonged prothrombin, red corpuscle and platelet electrophoresis time shorten.Hemorheology Study shows, Radix Angelicae Sinensis may increase cell surface charge, and promote the cell depolymerization by reducing plasma fibrinogen concentration, reduces blood viscosity.Foreign scholar Terasawa in 1985, the research of Katsutoshi etc. also shows, after po Radix Angelicae Sinensis extract (containing Z-ligustilide), the effect of the blood viscosity of reduction is arranged, more eastern Radix Angelicae Sinensis action time (Angeli-caacutilobe) extract (Z-ligustilide content is than the low several times of Radix Angelicae Sinensis) is long.Think thus, the anti thrombotic action of Radix Angelicae Sinensis may be relevant with the reduction viscosity of blood with anticoagulant, and Z-ligustilide may be one of its effective constituent.
5. on the impact of hemopoietic system.Early stage report shows, the Radix Angelicae Sinensis infusion can significantly promote oxyphorase and erythrocytic generation to mouse po.Its anti-anaemia effect may with contained vitamin B12. the compositions such as nicotinic acid, folinic acid and vitamin H, folic acid are relevant.Nearer research shows, Sodium Ferulate has anti-O2 and H2O to erythrocytic oxygenizement, and membrane lipid Peroxidation Product MDA is reduced, and can obviously reduce the hemolytic action caused by MDA.Under Sodium Ferulate exists, sickle anaemia erythrocyte lipid peroxidation in patients thing MDA increases and reduces with Sodium Ferulate concentration, and Sodium Ferulate can obviously reduce complement hemolysis, suppresses the combination of complement component 3 b (C3b) and erythrocyte membrane; On complement activation and erythrodegeneration without impact.Radix Angelicae Sinensis is the traditional Chinese medical science key medicine of enriching blood, invigorate blood circulation.Experimental study proves, Radix Angelicae Sinensis polysaccharide can increase peripheral red blood cells, white corpuscle, oxyphorase and bone marrow nucleated cell number, and this effect is particularly particularly evident when periphery hemocytopenia and marrow are suppressed.Wang Ya equality has been observed the impact of Radix Angelicae Sinensis polysaccharide on bone marrow depression-anemia mice peripheral blood due to normal and injection phenylhydrazine, 60 cobalt r x radiation xs and femur karyocyte sum, result shows, Radix Angelicae Sinensis polysaccharide has no significant effect red corpuscle, oxyphorase and the femur karyocyte sum of normal mouse, but can make white corpuscle and reticulocyte increase.Red corpuscle, oxyphorase, white corpuscle and femur number of nucleated cells to anemia mice recover to have remarkable promoter action.If can prevent the mouse peripheral blood oligoleukocythemia that Ultracortene-H causes to the injected in mice Radix Angelicae Sinensis polysaccharide.The experiment of Wang Yaping report also shows, Radix Angelicae Sinensis polysaccharide is to normal or through the mouse pluripotential hemopoietic stem cell (CFU-S) of radiation injury, its proliferation function of promotion is all arranged.No matter Radix Angelicae Sinensis polysaccharide is administered to donor or acceptor mouse, result is consistent.But can't prove this effect and directly stimulate CFU-S relevant.As if continuous tissue sections observation prompting Radix Angelicae Sinensis polysaccharide have no significant effect CFU-S propagation.The use Mice Body internal diffusion box methods such as kalimeris is fragrant and mice spleen colony method confirm that Radix Angelicae Sinensis polysaccharide all is increased significantly effect to the productive rate of mouse pluripotential hemopoietic stem cell (CFU-S), grain, monosystem progenitor cell (GM-CFU mono-day) and CFU-E in late period (CFU-E), and the Radix Angelicae Sinensis aqueous solution is without similar effect.The vitro culture such as Ge faithful and upright person also prove the normal and grain of bone marrow depression one anemia mice of Radix Angelicae Sinensis polysaccharide energy significant stimulation, the propagation of monosystem progenitor cell (CFU-GM), and its mechanism may be with promotion body secretory granule, (GM-CSF) be relevant for the monosystem G CFS.CFU-GM to tumor-bearing mice also shows as promoter action.Wang Ya equality nineteen ninety reports again, and Radix Angelicae Sinensis polysaccharide is to morning, the CFU-E in late period (BFU-E, CFU-E) of normal mouse and anemia mice the effect of stimulating proliferation, but still is difficult at present determine that Radix Angelicae Sinensis polysaccharide has direct effect to hemopoietic progenitor cell.Wish that the interior external source spleen colony of the use method such as Peter observed Radix Angelicae Sinensis injection to impacts such as pluripotential hemopoietic stem cell (CFU-S), spleen are long, the conclusion of its result and kalimeris virtue etc. is similar.The report of Hu Bi etc. also shows, Radix Angelicae Sinensis polysaccharide is given ip in mice before 30 minutes-24h of radiation exposure, can make approximately 80% animal survival 30 days, and can strengthen the recovery of animal hematopoietic function.According to above-mentioned result of study prompting, Radix Angelicae Sinensis polysaccharide may be one of effective constituent promoted in Radix Angelicae Sinensis hematopoiesis.One of Chinese angelica blood supplementing mechanism of action may stimulate CFU-S, proliferation of hematopoietic progenitors, differentiation relevant with Radix Angelicae Sinensis polysaccharide.Zhou Jingzi in 1985 etc. have observed after the water-leach liquor of making 20% and 40% (g/ml) after the volatile oil of going back is lost blood greatly to chmice acute the blood tonification effect that causes the deficiency of blood.The result demonstration, the oxyphorase (Hb) of the deficiency of blood mouse of ig Radix Angelicae Sinensis infusion and red corpuscle (RBC) value all have obviously and increase, and illustrate that Radix Angelicae Sinensis has extremely significant hematosis.
6. on the impact of immunizing power.Jiang Tianzhao English report in 1973, it is antigen immune big white mouse together with Pertussis Vaccine that the ascaris suum of take is extracted the protein bound dinitrophenol out, measure reactive antibody in rat serum, result shows, Radix Angelicae Sinensis can obviously suppress the generation of antibody, and the effect of its aqueous extract iv100mg/kg every day is equivalent to the effect of immunosuppressor azathioprine 5-10mg/kg.With sheep red blood cell immunity small white mouse, hemolytic plaque test proof Radix Angelicae Sinensis also has slight inhibition antibody forming cell's effect.Immune special rosettes method test for the microorganism teaching and research group of basic courses department of medical college of Beijing in 1987, Radix Angelicae Sinensis decoction ig, can significantly increase the mouse Rose and form number, and the mouse spleen volume increases, and weight significantly increases.Be that the splenocyte sum increases.Radix Angelicae Sinensis can also significantly strengthen the phagocytic function of animal peritoneal macrophage, improves the clean up speed of reticuloendothelial system to dyestuff.20% and 40% (g/ml) water-leach liquor of making after the volatile oil of going back (0.5ml/ days/only) and give mouse ig16 days, all can significantly strengthen Phagocytosis By The Peritoneal Macrophages In Mice.And can accelerate weight of mice speed.White and moist rivers etc. are also reported, sc5% Radix Angelicae Sinensis polysaccharide liquid and the 5% Radix Angelicae Sinensis aqueous solution all can improve the phagocytic function of Turnover of Mouse Peritoneal Macrophages, the effect of the two raising immunity of organisms is roughly the same, when chemotherapeutic endoxan and Radix Angelicae Sinensis polysaccharide share, although Mouse Weight descends to some extent, phagocytic function still can remain on normal level.Method is: the every gram body weight of male white mouse (body weight 15-20g) administration 0.3mg, and sc, once a day, successive administration 5-7 days.Adopt chicken blood, after salt water washing 3 times, be made into 5% chicken erythrocyte suspension, get 0.5ml and inject mouse peritoneal, after 16 hours, put to death mouse.Cut open the belly, use the normal saline flushing abdominal cavity, collect scavenger cell, drip on slide.37 ℃ of insulations 30 minutes, then fixing dyeing, microscopy, calculate phagocytic rate and phagocytic index.Separately there are some researches show, Radix Angelicae Sinensis injection is to external immune hemolysis unrestraint effect.Radix Angelicae Sinensis can significantly increase the mouse monokaryon macrophage system to mark I plasma proteins or Congo red Cl, increases the reticuloendothelial system phagocytic function.The reports such as Xu Lina all can promote mononuclear phygocyte system to Congo red Cl to mouse mainline Radix Angelicae Sinensis 16g/kg or Sodium Ferulate 00-200mg/kg significantly.To 0.2g/kg, can strengthen the ability that peritoneal macrophage is engulfed chicken red blood cell to mouse ig Sodium Ferulate 0.3g/kg or SC.Sc also has enhancement to Radix Angelicae Sinensis 20g/kg.Zhang Yunfen etc. also report that Radix Angelicae Sinensis decoction for tonifying blood (Radix Astragali, Radix Angelicae Sinensis) can significantly increase the mouse monokaryon mononuclear phagocyte system to Congo red Cl and promote the cytophagous phagocytic function of mouse peritoneal.Horse generation equality studied Radix Angelicae Sinensis decoction for tonifying blood and formed the impact of medicine on hematid immunity function nineteen ninety, result shows, Radix Angelicae Sinensis decoction for tonifying blood and composition medicine Radix Angelicae Sinensis, the Radix Astragali all can improve mouse red blood cell, and (the C3b receptor rosette rate reduces erythrocyte immune complex (CIC) rosette rate.If animal gives Ultracortene-H, ig Radix Angelicae Sinensis decoction for tonifying blood and Radix Angelicae Sinensis, the Radix Astragali in the time of its immune function depression, the low immunologic function of animal subject is able to obvious improvement.Also have experiment to show, po Radix Angelicae Sinensis or Radix Angelicae Sinensis decoction for tonifying blood decoction, form cell count to Rose and have no significant effect, but can improve serum antibody titer.1986 training Im reports, Radix Angelicae Sinensis neutral oil total acid has the phagocytic function that strengthens scavenger cell and promotes lymphocyte transformation effect (P<0.001); Radix Angelicae Sinensis polysaccharide has obvious promotion E mono-garland rate of formation and esterase dyeing positive rate effect (P<0.05); Total acid has the specific antibody IgG generation effect (P<0.05) of promotion.Therefore think that total acid both had been improved the immunity of organism effect, the effect of the humoral immunization of promotion arranged again.
7. Radix Angelicae Sinensis all has anti-microbial effect to external dysentery, typhoid fever, paratyphoid, intestinal bacteria, diphtheria corynebacterium, vibrio cholerae and a, B Hemolytic streptococcus etc.These product of Po can reduce the mouse capillary permeability.External application can be accelerated rabbit ear wound healing, and contrafluxion, white corpuscle and fiber are infiltrated, and newborn epithelium regeneration has hemostasis and strengthens the peripheral circulation effect local organization.Illustrate that Radix Angelicae Sinensis has antibiotic, antiinflammation.The clinical illnesss such as suppurative maxillary sinusitis, acute nephritis, bone phlebitis, scleroderma and psoriasis that can be used for.The Radix Angelicae Sinensis hot water extract has obvious restraining effect when its adjuvant arthritis acute attack to chronic rheumatoid venereal disease experimental animal model.
The invention has the beneficial effects as follows, the suitable various physique crowds of this health promoting wine, the normal phase drinks, can enriching yin boost qi, promote the production of body fluid to quench thirst, improve immunizing power, enhance metabolism, particularly for the crowd that gas, anemia are arranged, can play the effect of regulating physical function, and manufacture craft is simple, cost is the end of than, and the producer that generally possesses the wine working condition can implement.
Embodiment
By after picking of raw material, clean, cut into slices, then be placed in tank and add soaking in Chinese liquor, filter out the dregs of a decoction after soaking, the wine filtered out is allocated with honey or white sugar, enter again and filter, filling, to test, packing becomes finished product.
Embodiment mono-
12 parts of the roots of Dahurain angelica, 16 parts of Chinese cassia trees, 17 parts of sealworts, 18 parts of white tuckahoes, 4 parts of Flos Chrysanthemis, 1800 parts of white wine, 8 parts of the root of herbaceous peonys, 11 parts of Radix Angelicae Sinensis; By after picking of raw material, clean, cut into slices, then be placed in tank and add soaking in Chinese liquor, filter out the dregs of a decoction after soaking, the wine filtered out is allocated with honey or white sugar, enter again and filter, filling, to test, packing becomes finished product.
Embodiment bis-
14 parts of the roots of Dahurain angelica, 13 parts of Chinese cassia trees, 14 parts of sealworts, 16 parts of white tuckahoes, 5 parts of Flos Chrysanthemis, 1700 parts of white wine, 9 parts of the root of herbaceous peonys, 9 parts of Radix Angelicae Sinensis; By after picking of raw material, clean, cut into slices, then be placed in tank and add soaking in Chinese liquor, filter out the dregs of a decoction after soaking, the wine filtered out is allocated with honey or white sugar, enter again and filter, filling, to test, packing becomes finished product.
Embodiment tri-
16 parts of the roots of Dahurain angelica, 18 parts of Chinese cassia trees, 12 parts of sealworts, 12 parts of white tuckahoes, 6 parts of Flos Chrysanthemis, 2000 parts of white wine, 10 parts of the root of herbaceous peonys, 11 parts of Radix Angelicae Sinensis; By after picking of raw material, clean, cut into slices, then be placed in tank and add soaking in Chinese liquor, filter out the dregs of a decoction after soaking, the wine filtered out is allocated with honey or white sugar, enter again and filter, filling, to test, packing becomes finished product.
Embodiment tetra-
18 parts of the roots of Dahurain angelica, 12 parts of Chinese cassia trees, 13 parts of sealworts, 15 parts of white tuckahoes, 7 parts of Flos Chrysanthemis, 2100 parts of white wine, 11 parts of the root of herbaceous peonys, 13 parts of Radix Angelicae Sinensis; By after picking of raw material, clean, cut into slices, then be placed in tank and add soaking in Chinese liquor, filter out the dregs of a decoction after soaking, the wine filtered out is allocated with honey or white sugar, enter again and filter, filling, to test, packing becomes finished product.
Embodiment five
20 parts of the roots of Dahurain angelica, 20 parts of Chinese cassia trees, 17 parts of sealworts, 16 parts of white tuckahoes, 7 parts of Flos Chrysanthemis, 2200 parts of white wine, 5 parts of the root of herbaceous peonys, 12 parts of Radix Angelicae Sinensis; By after picking of raw material, clean, cut into slices, then be placed in tank and add soaking in Chinese liquor, filter out the dregs of a decoction after soaking, the wine filtered out is allocated with honey or white sugar, enter again and filter, filling, to test, packing becomes finished product.
Claims (2)
- One kind nourish blood, the compound formulation of Yin enriching heath care wine, it is characterized in that, combination formula is selected as root of Dahurain angelica 10-20 part, Chinese cassia tree 12-20 part, sealwort 12-18 part, white tuckahoe 10-18 part, Flos Chrysanthemi 3-7 part, white wine 1700-2200 part, root of herbaceous peony 7-12 part, Radix Angelicae Sinensis 8-13 part according to the quality proportioning; By after picking of raw material, clean, cut into slices, then be placed in tank and add soaking in Chinese liquor, filter out the dregs of a decoction after soaking, the wine filtered out is allocated with honey or white sugar, enter again and filter, filling, to test, packing becomes finished product.
- 2. according to claim 1ly a kind ofly nourish blood, the compound formulation of Yin enriching heath care wine, it is characterized in that, the best of breed formula is selected as 16 parts of the roots of Dahurain angelica, 14 parts of Chinese cassia trees, 15 parts of sealworts, 16 parts of white tuckahoes, 4 parts of Flos Chrysanthemis, 1900 parts of white wine, 9 parts of the root of herbaceous peonys, 11 parts of Radix Angelicae Sinensis according to the quality proportioning; By after picking of raw material, clean, cut into slices, then be placed in tank and add soaking in Chinese liquor, filter out the dregs of a decoction after soaking, the wine filtered out is allocated with honey or white sugar, enter again and filter, filling, to test, packing becomes finished product.
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| CN105420021A (en) * | 2015-12-17 | 2016-03-23 | 苏州垣梦新能源环保科技有限公司 | Method for brewing women-only liqueur by using bacteria-alga and rose composition |
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Application publication date: 20140108 |