CN103495011B - Preparation method of traditional Chinese medicine tablet for treating osteoporosis - Google Patents
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Abstract
The invention discloses a preparation method of a traditional Chinese medicine tablet for treating osteoporosis. The preparation method comprises the following steps of: milling radix clematidis, fructus psoraleae, eucommia ulmoides, dipsacus root, medlar, rhizoma anemarrhenae, achyranthes aspera, herba cistanche, oyster, Chinese angelica, cuscuta chinensis, asarum, caulis spatholobi, frankincense, fructus cnidii, and herba lycopi into 40-60-mesh fine powder, adding ethanol, the volume is 3-5 times that of the fine powder, for reflux extraction for 1-2 hours, filtering the resulting product, recycling the ethanol, concentrating the filtrate to thin cream, adding water into the decoction dreg for further decoction, concentrating the filtrated filtrate into thin cream, mixing the thin creams from the two times of concentration, concentrating the mixed thin cream to the thick cream at the density of 1.25-1.35, drying the thick cream to obtain a powder, adding 20-40 parts of starch, 15-25 parts of microcrystalline cellulose, 10-15 parts of hydroxy propyl cellulose, and 10-15 parts of mannitol into the obtained powder for uniform mixing, preparing the resulting mixture to a soft product by using proper 40-60% of ethanol, granulating the soft product by using a 18-20-mesh screen, drying the granulated product at 50-60 DEG C, straightening-granulating the dried product using a 16-18-mesh screen, adding 8-12 parts of hydroxy propyl cellulose, proper silicon dioxide, and proper magnesium stearate into the granulated product for uniform mixing, pressing the mixture for tabletting, and sugar-coating the tablet to obtain the traditional Chinese medicine tablet for treating the osteoporosis. The traditional Chinese medicine tablet has the efficacies of nourishing liver and kidney, tonifying essence and blood, consolidating the kidney and supplementing essence, and can be used for treating the osteoporosis.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation, particularly relate to a kind of preparation method for the treatment of osteoporotic Chinese medicinal tablet.
Background technology
Osteoporosis be taking bone amount reduce, the microstructure degeneration of bone is as main pathological characters, cause the fragility of bone to increase and be easy to occur a kind of general metabolism skeletal diseases of fracture.。Along with the trend of world population aging is day by day obvious, osteoporosis has become one of modal senile disease.Osteoporosis is serious threat people's health not only, and caused serious financial burden to family, society.
In Chinese dynasties medical book, there is no the record of osteoporosis name of disease, but rather similar to osteoporosis to the description of withered etc. the clinical symptoms of bone fistula, rheumatism involving the bone, bone.Most scholars think, primary osteoporosis should belong to bone fistula.Theory of Chinese medical science thinks, the morbidity of the osteoporosis relations that to be that multiple deficiency and stasis, apoplexy due to deficiency have real, many because of how really, instead of simple linear cause effect relation.Numerous scholars are obtaining progress aspect the research of osteosporosis resistant medicament.But research and development osteoporosis Chinese medicine is still in the junior stage, and really can be used in clinical patent medicine also little.The mechanism of action for the treatment of by Chinese herbs osteoporosis still imperfectly understands, also less to the research report of its effective ingredient.
At present, generally the about thing treatment of the vitamins osteoporosis that adopts calcium preparation, inhibition bone resorption medicine, Diphosphonate, the about thing of osteogenic treatment and promote mineralising clinically, but the effect of supplemented calcium of these about things is limited, and western about long-term taking medicine can increase the weight of the burden of liver, kidney, and anemia of pregnant woman is especially had to taboo.Therefore, follow traditional Chinese medicine theory, effective ingredient to treatment by Chinese herbs osteoporosis is more in depth studied, develop as early as possible that cost is low, good effect, the medicine that is easy to be accepted by extensive patients, being the development trend of current Effect of Anti osteoporosis agents, is also the needs of the modernization of Chinese medicine.
Summary of the invention
In order to overcome the deficiencies in the prior art, the present invention is according to theory of Chinese medical science, provide there is nourishing the liver and kidney, the osteoporotic Chinese medicinal tablet for the treatment of of benefiting essence-blood, benefiting essence and marrow effect.
The technical solution adopted for the present invention to solve the technical problems is as follows:
Treat a preparation method for osteoporotic middle about tablet, it is characterized in that being made by the raw material of Chinese medicine medicine of following weight proportioning:
Radix Clematidis 60-80 part, Fructus Psoraleae 50-70 part, Cortex Eucommiae 10-15 part, Radix Dipsaci 10-15 part, Fructus Lycii 8-15 part, Rhizoma Anemarrhenae 10-12 part, Radix Achyranthis 30-50 part, Herba Cistanches 20-40 part, Concha Ostreae 30-50 part, Radix Angelicae Sinensis 6-10 part, Semen Cuscutae 6-10 part, Herba Asari 10-15 part, Caulis Spatholobi 20-35 part, Olibanum 15-20 part, Fructus Cnidii 10-15 part, Herba Lycopi 10-15 part etc.;
Its preparation method is: above-mentioned raw material of Chinese medicine medicated powder is broken into 40-60 object fine powder, adds the alcohol reflux 1-2 hour of 3-5 times of volume, filter, reclaim ethanol, filtrate is condensed into clear paste, and about slag decocts with water again, and the filtrate after filtration is condensed into clear paste; Two parts of clear paste are merged, be condensed into the thick paste that density is 1.25-1.35, be dried to powder; Add starch 20-40 part, microcrystalline Cellulose 15-25 part, hydroxypropyl cellulose 10-15 part and mannitol part, mix, with 40-60% appropriate amount of ethanol soft material processed, 18-20 mesh sieve is granulated, and 50-60 DEG C dry, 16-18 mesh sieve granulate; Add again hydroxypropyl cellulose 8-12 part, silicon dioxide and magnesium stearate appropriate, mix, compacting in flakes, sugar coating and get final product.
Chinese medicinal tablet of the present invention is under Traditional Chinese medical theory and clinical experience guidance, selected Chinese prescription, and by the adjuvant and the preparation technology that optimize.In Chinese medicine composition of the present invention: Radix Clematidis has effect of expelling wind and removing dampness, removing obstruction in the collateral to relieve pain; Fructus Psoraleae has effect of warming the kidney to activate YANG, improving inspiration by invigorating kidney-QI antidiarrheal; The Cortex Eucommiae has effect of invigorating the liver and kidney, bone and muscle strengthening, blood pressure lowering; Radix Dipsaci has effect of kidney invigorating and YANG supporting, the raw marrow of bone strengthening; Fructus Lycii has effect of the liver and the kidney tonifying, nourishing the liver to improve visual acuity; Effect that the Rhizoma Anemarrhenae has clearing away heat-fire, promotes the production of body fluid and moisturize; Radix Achyranthis has effect of promoting blood circulation to remove blood stasis, damp eliminating diuresis; Herba Cistanches has temperature compensation essence and blood, protects the liver the effect of moisturizing; Concha Ostreae has effect of yin fluid astringing, YANG hyperactivity suppressing, hidroschesis, arresting seminal emission; Radix Angelicae Sinensis has to enrich blood invigorates blood circulation, withers through effect of hemostasis; Semen Cuscutae is according to effect of Europe the kidney invigorating and essence nourishing, nourishing the liver to improve visual acuity; Herba Asari has effect of expelling wind and cold; Caulis Spatholobi have enrich blood, invigorate blood circulation, effect of dredging collateral; Olibanum has regulating QI, invigorates blood circulation, effect of pain relieving; Fructus Cnidii has effect of warming the kidney to activate YANG, dispeiling pathogenic wind and removing dampness; Herba Lycopi has effect of blood circulation promoting and blood stasis dispelling, line water detumescence.Drug component in Chinese medicine composition of the present invention is through dialectical compatibility, complements each other using, and has synergism, plays altogether effect of nourishing the liver and kidney, benefiting essence-blood, benefiting essence and marrow, osteoporosis reached to the object for the treatment of both the principal and secondary aspects of a disease.
The component of the present composition all adopts natural raw material of Chinese medicine, and its preparation is easy, medicine source is wide, cost is low.It follows the prescriptions principle of the traditional Chinese medical science, and oral administration reaches significant therapeutic effect after using.
Detailed description of the invention
Below in conjunction with embodiment, the present invention will be further described.
Embodiment 1
One is treated osteoporotic middle about tablet, writes out a prescription as follows:
60 grams of Radix Clematidis, 50 grams of Fructus Psoraleaes, 12 grams of the Cortexs Eucommiae, 12 grams of Radix Dipsaci, 8 grams of Fructus Lyciis, 10 grams of the Rhizoma Anemarrhenaes, 40 grams of Radix Achyranthis, 25 grams of Herba Cistanches, 30 grams of Concha Ostreaes, 7 grams of Radix Angelicae Sinensis, 7 grams of Semen Cuscutae, 10 grams of Herba Asaris, 20 grams of Caulis Spatholobis, 15 grams of Olibanums, 10 grams of Fructus Cnidiis, 10 grams of Herba Lycopi;
Preparation method is: above-mentioned raw material of Chinese medicine medicated powder is broken into 40 object fine powders, adds the alcohol reflux 1.5 hours of 3 times of volumes, filter, reclaim ethanol, filtrate is condensed into clear paste, and medicinal residues decoct with water again, and the filtrate after filtration is condensed into clear paste; Two grams of clear paste are merged, be condensed into density and be 1.25 thick paste, be dried to powder; Add 12 grams, 20 grams of starch, 20 grams of microcrystalline Cellulose, 10 grams of hydroxypropyl celluloses and mannitol, mix, with 40% appropriate amount of ethanol soft material processed, 18 mesh sieves are granulated, and 50 DEG C dry, 16 mesh sieve granulate; Add again 8 grams of hydroxypropyl celluloses, silicon dioxide and magnesium stearate appropriate, mix, compacting in flakes, sugar coating and get final product.
Embodiment 2
One is treated osteoporotic Chinese medicinal tablet, writes out a prescription as follows:
70 grams of Radix Clematidis, 602 grams of Fructus Psoraleaes, 10 grams of the Cortexs Eucommiae, 13 grams of Radix Dipsaci, 10 grams of Fructus Lyciis, 10 grams of the Rhizoma Anemarrhenaes, 40 grams of Radix Achyranthis, 20 grams of Herba Cistanches, 40 grams of Concha Ostreaes, 8 grams of Radix Angelicae Sinensis, 8 grams of Semen Cuscutae, 12 grams of Herba Asaris, 25 grams of Caulis Spatholobis, 20 grams of Olibanums, 10 grams of Fructus Cnidiis, 10 grams of Herba Lycopi;
Preparation method is: above-mentioned raw material of Chinese medicine medicated powder is broken into 50 object fine powders, adds the alcohol reflux 1 hour of 4 times of volumes, filter, reclaim ethanol, filtrate is condensed into clear paste, and medicinal residues decoct with water again, and the filtrate after filtration is condensed into clear paste; Two grams of clear paste are merged, be condensed into density and be 1.30 thick paste, be dried to powder; Add 12 grams, 20 grams of starch, 20 grams of microcrystalline Cellulose, 12 grams of hydroxypropyl celluloses and mannitol, mix, with 60% appropriate amount of ethanol soft material processed, 20 mesh sieves are granulated, and 60 DEG C dry, 18 mesh sieve granulate; Add again 10 grams of hydroxypropyl celluloses, silicon dioxide and magnesium stearate appropriate, mix, compacting in flakes, sugar coating and get final product.
Embodiment 3
One is treated osteoporotic Chinese medicinal tablet, writes out a prescription as follows:
80 grams of Radix Clematidis, 70 grams of Fructus Psoraleaes, 12 grams of the Cortexs Eucommiae, 12 grams of Radix Dipsaci, 10 grams of Fructus Lyciis, 12 grams of the Rhizoma Anemarrhenaes, 50 grams of Radix Achyranthis, 40 grams of Herba Cistanches, 50 grams of Concha Ostreaes, 10 grams of Radix Angelicae Sinensis, 10 grams of Semen Cuscutae, 15 grams of Herba Asaris, 35 grams of Caulis Spatholobis, 20 grams of Olibanums, 15 grams of Fructus Cnidiis, 15 grams of Herba Lycopi;
Preparation method is: above-mentioned middle about crude drug is ground into 50 object fine powders, adds the alcohol reflux 2 hours of 5 times of volumes, filter, reclaim ethanol, filtrate is condensed into clear paste, and medicinal residues decoct with water again, and the filtrate after filtration is condensed into clear paste; Two grams of clear paste are merged, be condensed into density and be 1.35 thick paste, be dried to powder; Add 12 grams, 40 grams of starch, 25 grams of microcrystalline Cellulose, 15 grams of hydroxypropyl celluloses and mannitol, mix, with 50% appropriate amount of ethanol soft material processed, 20 mesh sieves are granulated, and 60 DEG C dry, 18 mesh sieve granulate; Add again 12 parts of hydroxypropyl celluloses, silicon dioxide and magnesium stearate appropriate, mix, compacting in flakes, sugar coating and get final product.
Test example 1
One, test method:
Prepare Chinese medicinal tablet of the present invention according to embodiment 1, adopt randomized, double-blind, Yang Shengyue (GUSHUKANG KELIJI) parallel control, 200 experimenters are given approximately, Chinese medicinal tablet of the present invention every day three times, each two administrations, treat four months altogether.Wherein, Chinese medicinal tablet 120 examples of the present invention, GUSHUKANG KELIJI 80 examples.Then, the relatively comprehensive therapeutic effect after two kinds of about things uses and the bone density of different parts, to judge the result of use of the about thing of the present invention.
Two, result of the test:
Table 1: the osteoporosis comprehensive therapeutic effect of two groups of medicines
| Group | Number of cases | Effective | Effectively | Invalid | Total effective rate |
| Of the present invention group | 120 | 76(63.3％) | 39(32.5％) | 5(4.2％) | 95.8％ |
| Matched group | 80 | 55(68.7％) | 18(22.5％) | 7(8.8％) | 91.2％ |
Table 2: after two groups of Drug therapys, lumbar vertebra density value improves curative effect comparison
| Group | Number of cases | Effective | Effectively | Invalid | Total effective rate |
| Of the present invention group | 112 | 45(40.2％) | 32(28.6％) | 35(31.2％) | 68.8％ |
| Matched group | 38 | 17(44.7％) | 8(21.1％) | 13(34.2％) | 65.8％ |
Table 3: after two groups of Drug therapys, femoral bmd value is improved curative effect comparison
| Group | Number of cases | Effective | Effectively | Invalid | Total effective rate |
| Of the present invention group | 108 | 63(58.3％) | 31(28.7％) | 14(13.0％) | 87.0％ |
| Matched group | 40 | 12(30.0％) | 15(37.5％) | 13(32.5％) | 67.5％ |
Table 4: after two groups of about thing treatments, greater trochanter bone density value improves curative effect comparison
| Group | Number of cases | Effective | Effectively | Invalid | Total effective rate |
| Of the present invention group | 105 | 56(53.3％) | 21(20.0％) | 28(26.7％) | 73.3％ |
| Matched group | 36 | 13(36.1％) | 8(22.2％) | 15(41.7％) | 58.3％ |
Table 1 to table 2 is respectively two kinds of comprehensive therapeutic effects after drug use and the bone density comparison of different parts.As can be seen from Table 1, the total effective rate of Chinese medicinal tablet of the present invention is obviously greater than matched group, illustrates that middle about tablet of the present invention can effectively treat osteoporosis; From table, 2-4 can find out, Chinese medicinal tablet of the present invention can improve the bone density of the different parts such as rear lumbar vertebra, rear femur, greater trochanter, and total effective rate will be apparently higher than matched group.
Claims (2)
1. the osteoporotic Chinese medicinal tablet for the treatment of, is characterized in that being made up of the raw material of Chinese medicine medicine of following weight proportioning:
Radix Clematidis 60-80 part, Fructus Psoraleae 50-70 part, Cortex Eucommiae 10-15 part, Radix Dipsaci 10-15 part, Fructus Lycii 8-15 part, Rhizoma Anemarrhenae 10-12 part, Radix Achyranthis 30-50 part, Herba Cistanches 20-40 part, Concha Ostreae 30-50 part, Radix Angelicae Sinensis 6-10 part, Semen Cuscutae 6-10 part, Herba Asari 10-15 part, Caulis Spatholobi 20-35 part, Olibanum 15-20 part, Fructus Cnidii 10-15 part, Herba Lycopi 10-15 part.
2. a preparation method for the osteoporotic Chinese medicinal tablet for the treatment of as claimed in claim 1, is characterized in that being made up of the raw material of Chinese medicine medicine of following weight proportioning:
Radix Clematidis 60-80 part, Fructus Psoraleae 50-70 part, Cortex Eucommiae 10-15 part, Radix Dipsaci 10-15 part, Fructus Lycii 8-15 part, Rhizoma Anemarrhenae 10-12 part, Radix Achyranthis 30-50 part, Herba Cistanches 20-40 part, Concha Ostreae 30-50 part, Radix Angelicae Sinensis 6-10 part, Semen Cuscutae 6-10 part, Herba Asari 10-15 part, Caulis Spatholobi 20-35 part, Olibanum 15-20 part, Fructus Cnidii 10-15 part, Herba Lycopi 10-15 part;
Its preparation method is: above-mentioned raw material of Chinese medicine medicated powder is broken into 40-60 object fine powder, adds the alcohol reflux 1-2 hour of 3-5 times of volume, filter, reclaim ethanol, filtrate is condensed into clear paste, and medicinal residues decoct with water again, and the filtrate after filtration is condensed into clear paste; Two parts of clear paste are merged, be condensed into the thick paste that density is 1.25-1.35, be dried to powder; Add starch 20-40 part, microcrystalline Cellulose 15-25 part, hydroxypropyl cellulose 10-15 part and mannitol 10-15 part, mix, with 40-60% appropriate amount of ethanol soft material processed, 18-20 mesh sieve is granulated, and 50-60 DEG C dry, 16-18 mesh sieve granulate; Add again hydroxypropyl cellulose 8-12 part, silicon dioxide and magnesium stearate appropriate, mix, compacting in flakes, sugar coating and get final product.
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Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104523999B (en) * | 2015-01-16 | 2018-08-31 | 邓运明 | It is a kind of for the Chinese medicine preparation of osteoporosis and its preparation method of paste |
| CN105582263A (en) * | 2016-03-28 | 2016-05-18 | 唐家婷 | Chinese herbal preparation for treating osteoporosis and preparing method thereof |
| CN106072646A (en) * | 2016-06-27 | 2016-11-09 | 天津天狮生物发展有限公司 | A kind of compositions increasing bone density of menopause females and preparation method thereof |
| CN106138960B (en) * | 2016-07-04 | 2019-05-14 | 北京积水潭医院 | Medical composition and its use |
| CN109432035A (en) * | 2018-11-29 | 2019-03-08 | 广东省惠州市中药厂有限公司 | GUCIPING PIAN and preparation method thereof |
| CN113288934B (en) * | 2020-03-25 | 2022-08-30 | 厦门大学 | Herba lycopi extract, preparation method and application thereof |
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| CN102106923A (en) * | 2009-12-29 | 2011-06-29 | 南京中医药大学 | Chinese medicinal preparation for treating osteoporosis |
| CN102872299B (en) * | 2012-09-26 | 2014-04-30 | 吴淑玺 | Medicine compound for treating osteoporosis and osteoporosis fracture |
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