CN103495011A - Preparation method of traditional Chinese medicine tablet for treating osteoporosis - Google Patents
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Abstract
The invention discloses a preparation method of a traditional Chinese medicine tablet for treating osteoporosis. The preparation method comprises the following steps of: milling radix clematidis, fructus psoraleae, eucommia ulmoides, dipsacus root, medlar, rhizoma anemarrhenae, achyranthes aspera, herba cistanche, oyster, Chinese angelica, cuscuta chinensis, asarum, caulis spatholobi, frankincense, fructus cnidii, and herba lycopi into 40-60-mesh fine powder, adding ethanol, the volume is 3-5 times that of the fine powder, for reflux extraction for 1-2 hours, filtering the resulting product, recycling the ethanol, concentrating the filtrate to thin cream, adding water into the decoction dreg for further decoction, concentrating the filtrated filtrate into thin cream, mixing the thin creams from the two times of concentration, concentrating the mixed thin cream to the thick cream at the density of 1.25-1.35, drying the thick cream to obtain a powder, adding 20-40 parts of starch, 15-25 parts of microcrystalline cellulose, 10-15 parts of hydroxy propyl cellulose, and 10-15 parts of mannitol into the obtained powder for uniform mixing, preparing the resulting mixture to a soft product by using proper 40-60% of ethanol, granulating the soft product by using a 18-20-mesh screen, drying the granulated product at 50-60 DEG C, straightening-granulating the dried product using a 16-18-mesh screen, adding 8-12 parts of hydroxy propyl cellulose, proper silicon dioxide, and proper magnesium stearate into the granulated product for uniform mixing, pressing the mixture for tabletting, and sugar-coating the tablet to obtain the traditional Chinese medicine tablet for treating the osteoporosis. The traditional Chinese medicine tablet has the efficacies of nourishing liver and kidney, tonifying essence and blood, consolidating the kidney and supplementing essence, and can be used for treating the osteoporosis.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation, particularly relate to a kind of preparation method for the treatment of osteoporotic Chinese medicinal tablet.
Background technology
Osteoporosis is to take that the bone amount reduces, the microstructure degeneration of bone is main pathological characters, a kind of general metabolism skeletal diseases that causes the fragility of bone to increase and be easy to occur fracture.。Along with the trend of world population aging is day by day obvious, osteoporosis has become one of modal senile disease.Osteoporosis is serious threat people's health not only, and caused serious financial burden to family, society.
There is no the record of osteoporosis name of disease in the Chinese dynasties medical book, but the description of withered etc. clinical symptoms is rather similar to osteoporosis to bone fistula, rheumatism involving the bone, bone.Most scholars think, primary osteoporosis should belong to bone fistula.Theory of Chinese medical science thinks, the morbidity of the osteoporosis relations that to be that multiple deficiency and stasis, apoplexy due to deficiency have real, many because of how really, rather than simple linear cause effect relation.Numerous scholars are obtaining progress aspect the research of osteosporosis resistant medicament.But research and development osteoporosis Chinese medicine still is in the junior stage, and really can be used in clinical patent medicine also seldom.The mechanism of action for the treatment of by Chinese herbs osteoporosis still imperfectly understands, also less to the research report of its effective ingredient.
At present, generally the about thing treatment of the vitamins osteoporosis that adopts calcium preparation, inhibition bone resorption medicine, Diphosphonate, the about thing of osteogenic treatment and promote mineralising clinically, but the effect of supplemented calcium of these about things is limited, and western about long-term taking medicine can increase the weight of the burden of liver, kidney, and the anemia of pregnant woman is especially had to taboo.Therefore, follow traditional Chinese medicine theory, effective ingredient to the treatment by Chinese herbs osteoporosis is more in depth studied, develop as early as possible that cost is low, good effect, the medicine that is easy to be accepted by extensive patients, being the development trend of current Effect of Anti osteoporosis agents, is also the needs of the modernization of Chinese medicine.
Summary of the invention
In order to overcome the deficiencies in the prior art, the present invention is according to theory of Chinese medical science, provide there is nourishing the liver and kidney, the osteoporotic Chinese medicinal tablet for the treatment of of benefiting essence-blood, benefiting essence and marrow effect.
The technical solution adopted for the present invention to solve the technical problems is as follows:
A kind of preparation method for the treatment of osteoporotic middle about tablet is characterized in that being made by the raw material of Chinese medicine medicine of following weight proportioning:
Radix Clematidis 60-80 part, Fructus Psoraleae 50-70 part, Cortex Eucommiae 10-15 part, Radix Dipsaci 10-15 part, Fructus Lycii 8-15 part, Rhizoma Anemarrhenae 10-12 part, Radix Achyranthis 30-50 part, Herba Cistanches 20-40 part, Concha Ostreae 30-50 part, Radix Angelicae Sinensis 6-10 part, Semen Cuscutae 6-10 part, Herba Asari 10-15 part, Caulis Spatholobi 20-35 part, Olibanum 15-20 part, Fructus Cnidii 10-15 part, Herba Lycopi 10-15 part etc.;
Its preparation method is: above-mentioned raw material of Chinese medicine medicated powder is broken into to 40-60 purpose fine powder, adds the alcohol reflux 1-2 hour of 3-5 times of volume, filter, reclaim ethanol, filtrate is condensed into clear paste, and about slag decocts with water again, and the filtrate after filtration is condensed into clear paste; Two parts of clear paste are merged, be condensed into the thick paste that density is 1.25-1.35, be dried to powder; Add starch 20-40 part, microcrystalline Cellulose 15-25 part, hydroxypropyl cellulose 10-15 part and mannitol part, mix, with 40-60% appropriate amount of ethanol soft material processed, the 18-20 mesh sieve is granulated, 50-60 ℃ of drying, 16-18 mesh sieve granulate; Add again hydroxypropyl cellulose 8-12 part, silicon dioxide and magnesium stearate appropriate, mix, compacting in flakes, sugar coating and get final product.
Chinese medicinal tablet of the present invention is under Traditional Chinese medical theory and clinical experience guidance, selected Chinese prescription, and by the adjuvant and the preparation technology that optimize.In Chinese medicine composition of the present invention: Radix Clematidis has the effect of expelling wind and removing dampness, removing obstruction in the collateral to relieve pain; Fructus Psoraleae has the effect of warming the kidney to activate YANG, improving inspiration by invigorating kidney-QI antidiarrheal; The Cortex Eucommiae has the effect of invigorating the liver and kidney, bone and muscle strengthening, blood pressure lowering; Radix Dipsaci has the effect of kidney invigorating and YANG supporting, the living marrow of bone strengthening; Fructus Lycii has the effect of the liver and the kidney tonifying, nourishing the liver to improve visual acuity; The effect that the Rhizoma Anemarrhenae has clearing away heat-fire, promotes the production of body fluid and moisturize; Radix Achyranthis has the effect of promoting blood circulation to remove blood stasis, damp eliminating diuresis; Herba Cistanches has the temperature compensation essence and blood, protects the liver the effect of moisturizing; Concha Ostreae has the effect of yin fluid astringing, YANG hyperactivity suppressing, hidroschesis, arresting seminal emission; Radix Angelicae Sinensis has to enrich blood invigorates blood circulation, withers through the effect of hemostasis; Semen Cuscutae is according to the effect of Europe the kidney invigorating and essence nourishing, nourishing the liver to improve visual acuity; Herba Asari has the effect of expelling wind and cold; Caulis Spatholobi have enrich blood, invigorate blood circulation, the effect of dredging collateral; Olibanum has regulating QI, invigorates blood circulation, the effect of pain relieving; Fructus Cnidii has the effect of warming the kidney to activate YANG, dispeiling pathogenic wind and removing dampness; The Herba Lycopi has the effect of blood circulation promoting and blood stasis dispelling, line water detumescence.Drug component in Chinese medicine composition of the present invention is through dialectical compatibility, complements each other using, and has synergism, plays altogether the effect of nourishing the liver and kidney, benefiting essence-blood, benefiting essence and marrow, osteoporosis reached to the purpose for the treatment of both the principal and secondary aspects of a disease.
The component of the present composition all adopts natural raw material of Chinese medicine, and its preparation is easy, the medicine source is wide, cost is low.It follows the prescriptions principle of the traditional Chinese medical science, and oral administration reaches significant therapeutic effect after using.
The specific embodiment
Below in conjunction with embodiment, the present invention will be further described.
Embodiment 1
A kind ofly treat osteoporotic middle about tablet, write out a prescription as follows:
Radix Clematidis 60 grams, Fructus Psoraleae 50 grams, the Cortex Eucommiae 12 grams, Radix Dipsaci 12 grams, Fructus Lycii 8 grams, the Rhizoma Anemarrhenae 10 grams, Radix Achyranthis 40 grams, Herba Cistanches 25 grams, Concha Ostreae 30 grams, Radix Angelicae Sinensis 7 grams, Semen Cuscutae 7 grams, Herba Asari 10 grams, Caulis Spatholobi 20 grams, Olibanum 15 grams, Fructus Cnidii 10 grams, Herba Lycopi's 10 grams;
Preparation method is: above-mentioned raw material of Chinese medicine medicated powder is broken into to 40 purpose fine powders, adds the alcohol reflux 1.5 hours of 3 times of volumes, filter, reclaim ethanol, filtrate is condensed into clear paste, and medicinal residues decoct with water again, and the filtrate after filtration is condensed into clear paste; Two gram clear paste are merged, be condensed into the thick paste that density is 1.25, be dried to powder; Add starch 20 grams, microcrystalline Cellulose 20 grams, hydroxypropyl cellulose 10 grams and mannitol 12 grams, mix, with 40% appropriate amount of ethanol soft material processed, 18 mesh sieves are granulated, 50 ℃ of dryings, 16 mesh sieve granulate; Add again hydroxypropyl cellulose 8 grams, silicon dioxide and magnesium stearate appropriate, mix, compacting in flakes, sugar coating and get final product.
Embodiment 2
A kind ofly treat osteoporotic Chinese medicinal tablet, write out a prescription as follows:
Radix Clematidis 70 grams, Fructus Psoraleae 602 grams, the Cortex Eucommiae 10 grams, Radix Dipsaci 13 grams, Fructus Lycii 10 grams, the Rhizoma Anemarrhenae 10 grams, Radix Achyranthis 40 grams, Herba Cistanches 20 grams, Concha Ostreae 40 grams, Radix Angelicae Sinensis 8 grams, Semen Cuscutae 8 grams, Herba Asari 12 grams, Caulis Spatholobi 25 grams, Olibanum 20 grams, Fructus Cnidii 10 grams, Herba Lycopi's 10 grams;
Preparation method is: above-mentioned raw material of Chinese medicine medicated powder is broken into to 50 purpose fine powders, adds the alcohol reflux 1 hour of 4 times of volumes, filter, reclaim ethanol, filtrate is condensed into clear paste, and medicinal residues decoct with water again, and the filtrate after filtration is condensed into clear paste; Two gram clear paste are merged, be condensed into the thick paste that density is 1.30, be dried to powder; Add starch 20 grams, microcrystalline Cellulose 20 grams, hydroxypropyl cellulose 12 grams and mannitol 12 grams, mix, with 60% appropriate amount of ethanol soft material processed, 20 mesh sieves are granulated, 60 ℃ of dryings, 18 mesh sieve granulate; Add again hydroxypropyl cellulose 10 grams, silicon dioxide and magnesium stearate appropriate, mix, compacting in flakes, sugar coating and get final product.
Embodiment 3
A kind ofly treat osteoporotic Chinese medicinal tablet, write out a prescription as follows:
Radix Clematidis 80 grams, Fructus Psoraleae 70 grams, the Cortex Eucommiae 12 grams, Radix Dipsaci 12 grams, Fructus Lycii 10 grams, the Rhizoma Anemarrhenae 12 grams, Radix Achyranthis 50 grams, Herba Cistanches 40 grams, Concha Ostreae 50 grams, Radix Angelicae Sinensis 10 grams, Semen Cuscutae 10 grams, Herba Asari 15 grams, Caulis Spatholobi 35 grams, Olibanum 20 grams, Fructus Cnidii 15 grams, Herba Lycopi's 15 grams;
Preparation method is: above-mentioned middle about crude drug is ground into to 50 purpose fine powders, adds the alcohol reflux 2 hours of 5 times of volumes, filter, reclaim ethanol, filtrate is condensed into clear paste, and medicinal residues decoct with water again, and the filtrate after filtration is condensed into clear paste; Two gram clear paste are merged, be condensed into the thick paste that density is 1.35, be dried to powder; Add starch 40 grams, microcrystalline Cellulose 25 grams, hydroxypropyl cellulose 15 grams and mannitol 12 grams, mix, with 50% appropriate amount of ethanol soft material processed, 20 mesh sieves are granulated, 60 ℃ of dryings, 18 mesh sieve granulate; Add again 12 parts of hydroxypropyl celluloses, silicon dioxide and magnesium stearate appropriate, mix, compacting in flakes, sugar coating and get final product.
Test example 1
One, test method:
According to embodiment 1 preparation Chinese medicinal tablet of the present invention, adopt randomized, double-blind, Yang Shengyue (GUSHUKANG KELIJI) parallel control, 200 experimenters to be given approximately, Chinese medicinal tablet of the present invention every day three times, each two administrations, treat four months altogether.Wherein, Chinese medicinal tablet 120 examples of the present invention, GUSHUKANG KELIJI 80 examples.Then, the comprehensive therapeutic effect after two kinds of about things of comparison are used and the bone density of different parts, with the result of use of the about thing of judgement the present invention.
Two, result of the test:
Table 1: the osteoporosis comprehensive therapeutic effect of two groups of medicines
| Group | Number of cases | Produce effects | Effectively | Invalid | Total effective rate |
| Of the present invention group | 120 | 76(63.3％) | 39(32.5％) | 5(4.2％) | 95.8％ |
| Matched group | 80 | 55(68.7％) | 18(22.5％) | 7(8.8％) | 91.2％ |
Table 2: after two groups of Drug therapys, the lumbar vertebra density value improves curative effect relatively
| Group | Number of cases | Produce effects | Effectively | Invalid | Total effective rate |
| Of the present invention group | 112 | 45(40.2％) | 32(28.6％) | 35(31.2％) | 68.8％ |
| Matched group | 38 | 17(44.7％) | 8(21.1％) | 13(34.2％) | 65.8％ |
Table 3: after two groups of Drug therapys, the femoral bmd value is improved curative effect relatively
| Group | Number of cases | Produce effects | Effectively | Invalid | Total effective rate |
| Of the present invention group | 108 | 63(58.3％) | 31(28.7％) | 14(13.0％) | 87.0％ |
| Matched group | 40 | 12(30.0％) | 15(37.5％) | 13(32.5％) | 67.5％ |
Table 4: after two groups of about thing treatments, the greater trochanter bone density value improves curative effect relatively
| Group | Number of cases | Produce effects | Effectively | Invalid | Total effective rate |
| Of the present invention group | 105 | 56(53.3％) | 21(20.0％) | 28(26.7％) | 73.3％ |
| Matched group | 36 | 13(36.1％) | 8(22.2％) | 15(41.7％) | 58.3％ |
Table 1 to table 2 be respectively two kinds of comprehensive therapeutic effects after drug use and different parts bone density relatively.As can be seen from Table 1, the total effective rate of Chinese medicinal tablet of the present invention obviously is greater than matched group, illustrates that middle about tablet of the present invention can effectively treat osteoporosis; From table, 2-4 can find out, the bone density of the different parts such as lumbar vertebra, rear femur, greater trochanter after Chinese medicinal tablet of the present invention can improve, and total effective rate will be apparently higher than matched group.
Claims (2)
1. treat osteoporotic Chinese medicinal tablet for one kind, it is characterized in that being made by the raw material of Chinese medicine medicine of following weight proportioning:
Radix Clematidis 60-80 part, Fructus Psoraleae 50-70 part, Cortex Eucommiae 10-15 part, Radix Dipsaci 10-15 part, Fructus Lycii 8-15 part, Rhizoma Anemarrhenae 10-12 part, Radix Achyranthis 30-50 part, Herba Cistanches 20-40 part, Concha Ostreae 30-50 part, Radix Angelicae Sinensis 6-10 part, Semen Cuscutae 6-10 part, Herba Asari 10-15 part, Caulis Spatholobi 20-35 part, Olibanum 15-20 part, Fructus Cnidii 10-15 part, Herba Lycopi 10-15 part.
2. the preparation method of the osteoporotic Chinese medicinal tablet for the treatment of as claimed in claim 1 is characterized in that being made by the raw material of Chinese medicine medicine of following weight proportioning:
Radix Clematidis 60-80 part, Fructus Psoraleae 50-70 part, Cortex Eucommiae 10-15 part, Radix Dipsaci 10-15 part, Fructus Lycii 8-15 part, Rhizoma Anemarrhenae 10-12 part, Radix Achyranthis 30-50 part, Herba Cistanches 20-40 part, Concha Ostreae 30-50 part, Radix Angelicae Sinensis 6-10 part, Semen Cuscutae 6-10 part, Herba Asari 10-15 part, Caulis Spatholobi 20-35 part, Olibanum 15-20 part, Fructus Cnidii 10-15 part, Herba Lycopi 10-15 part;
Its preparation method is: above-mentioned raw material of Chinese medicine medicated powder is broken into to 40-60 purpose fine powder, adds the alcohol reflux 1-2 hour of 3-5 times of volume, filter, reclaim ethanol, filtrate is condensed into clear paste, and medicinal residues decoct with water again, and the filtrate after filtration is condensed into clear paste; Two parts of clear paste are merged, be condensed into the thick paste that density is 1.25-1.35, be dried to powder; Add starch 20-40 part, microcrystalline Cellulose 15-25 part, hydroxypropyl cellulose 10-15 part and mannitol 10-15 part, mix, with 40-60% appropriate amount of ethanol soft material processed, the 18-20 mesh sieve is granulated, 50-60 ℃ of drying, 16-18 mesh sieve granulate; Add again hydroxypropyl cellulose 8-12 part, silicon dioxide and magnesium stearate appropriate, mix, compacting in flakes, sugar coating and get final product.
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104523999A (en) * | 2015-01-16 | 2015-04-22 | 邓运明 | Traditional Chinese medicine preparation for osteoporosis and preparation method of ointment of traditional Chinese medicine preparation |
| CN105582263A (en) * | 2016-03-28 | 2016-05-18 | 唐家婷 | Chinese herbal preparation for treating osteoporosis and preparing method thereof |
| CN106072646A (en) * | 2016-06-27 | 2016-11-09 | 天津天狮生物发展有限公司 | A kind of compositions increasing bone density of menopause females and preparation method thereof |
| CN106138960A (en) * | 2016-07-04 | 2016-11-23 | 孙成栋 | Medical composition and its use |
| CN109432035A (en) * | 2018-11-29 | 2019-03-08 | 广东省惠州市中药厂有限公司 | GUCIPING PIAN and preparation method thereof |
| CN113288934A (en) * | 2020-03-25 | 2021-08-24 | 厦门大学 | Herba lycopi extract, preparation method and application thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102106923A (en) * | 2009-12-29 | 2011-06-29 | 南京中医药大学 | Chinese medicinal preparation for treating osteoporosis |
| CN102872299A (en) * | 2012-09-26 | 2013-01-16 | 吴淑玺 | Medicine compound for treating osteoporosis and osteoporosis fracture |
-
2013
- 2013-09-24 CN CN201310445270.9A patent/CN103495011B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102106923A (en) * | 2009-12-29 | 2011-06-29 | 南京中医药大学 | Chinese medicinal preparation for treating osteoporosis |
| CN102872299A (en) * | 2012-09-26 | 2013-01-16 | 吴淑玺 | Medicine compound for treating osteoporosis and osteoporosis fracture |
Non-Patent Citations (2)
| Title |
|---|
| 刘春颖等: "金乌骨通胶囊对去卵巢骨质疏松模型大鼠松质骨骨质量的影响", 《中国中医骨伤科杂志》 * |
| 张仕兵: "原发性骨质疏松症的中医药治疗临床进展", 《云南中医中药杂志》 * |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104523999A (en) * | 2015-01-16 | 2015-04-22 | 邓运明 | Traditional Chinese medicine preparation for osteoporosis and preparation method of ointment of traditional Chinese medicine preparation |
| CN104523999B (en) * | 2015-01-16 | 2018-08-31 | 邓运明 | It is a kind of for the Chinese medicine preparation of osteoporosis and its preparation method of paste |
| CN105582263A (en) * | 2016-03-28 | 2016-05-18 | 唐家婷 | Chinese herbal preparation for treating osteoporosis and preparing method thereof |
| CN106072646A (en) * | 2016-06-27 | 2016-11-09 | 天津天狮生物发展有限公司 | A kind of compositions increasing bone density of menopause females and preparation method thereof |
| CN106138960A (en) * | 2016-07-04 | 2016-11-23 | 孙成栋 | Medical composition and its use |
| CN106138960B (en) * | 2016-07-04 | 2019-05-14 | 北京积水潭医院 | Medical composition and its use |
| CN109432035A (en) * | 2018-11-29 | 2019-03-08 | 广东省惠州市中药厂有限公司 | GUCIPING PIAN and preparation method thereof |
| CN113288934A (en) * | 2020-03-25 | 2021-08-24 | 厦门大学 | Herba lycopi extract, preparation method and application thereof |
| WO2021190588A1 (en) * | 2020-03-25 | 2021-09-30 | 厦门大学 | Herba lycopi extract and preparation method therefor and use thereof |
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| Publication number | Publication date |
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| CN103495011B (en) | 2014-09-03 |
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