CN104826016A - Pharmaceutical composition for treating hyperplasia of mammary glands as well as preparation method and application thereof - Google Patents
Pharmaceutical composition for treating hyperplasia of mammary glands as well as preparation method and application thereof Download PDFInfo
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Abstract
The invention discloses a pharmaceutical composition for treating hyperplasia of mammary glands. The pharmaceutical composition is a preparation prepared from the following raw materials in parts by weight: 5-15 parts of angelica dahurica, 1-11 parts of radix bupleuri, 10-20 parts of roasted atractylodes macrocephala, 1-11 parts of angelica, 15-25 parts of calcined oyster shell, 3-13 parts of zedoary, 10-20 parts of poria cocos, 1-11 parts of cassia twig, 7-17 parts of seaweed, 5-15 parts of mangnolia officinalis, 7-17 parts of hoantchy root, 3-13 parts of agastache, 5-15 parts of tangerine seeds, 7-17 parts of kelp, 1-9 parts of gentian, 1-9 parts of myrrh, 1-5 parts of frankincense, 3-13 parts of rhizoma sparganii, 1-9 parts of rhizoma cimicifugae, 10-20 parts of fructus polygoni orientalis, 1-7 parts of leeches, 10-20 parts of loofah sponge, 3-13 parts of peach kernels, 5-15 parts of stevia rebaudiana, 1-11 parts of excrementum pteropi, 3-13 parts of selfheal, 10-20 parts of figwort root, 1-5 parts of dragon's blood and 7-17 parts of fritillary bulb. The pharmaceutical composition provided by the invention can effectively relieve breast pain, breast lumps, nipple discharge, menstrual disorder, emotion alteration and other symptoms of hyperplasia of mammary glands, has a high effective rate, can be used for treating I-phase hyperplasia, II-phase hyperplasia and III-phase hyperplasia of mammary glands, and provides a new clinical medicine choice.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition for the treatment of cyclomastopathy and its production and use.
Background technology
Cyclomastopathy refers to breast epithelium and proliferation of fibrous tissue, mammary gland tissue conduit and newborn lobule degeneration structurally and the growth of Progressive symmetric erythrokeratodermia connective tissue.Cyclomastopathy is the common disease of a kind of gynecological, be apt to occur in the middle-aged women about 25-39 year, because be women's sexual function the most vigorous period during this period of time, show as the different parts single-shot of breast or multiple grow some lumps, quality is soft, obscure boundary, movable, often with pain in various degree, after especially premenstrual in the moon, tired or the anxious state of mind such as angry (traditional Chinese medical science claims the stagnation of QI) time, lump increases, pain increases the weight of, and after menstruation, lump obviously reduces, pain relief, pain is generally distending pain, little tingle.
Cyclomastopathy can be divided into I phase cyclomastopathy according to light and heavy degree, II phase mammary gland increases and III phase cyclomastopathy.Cyclomastopathy (I phase cyclomastopathy) is the initial stage hypertrophy of mammary gland, mostly occurs at 25 ~ 35 years old, and Symptoms is comparatively light, belongs to cyclomastopathy I phase; Adenosis of breast (mammary duct ectasia, II phase cyclomastopathy) is further developing of mammary gland initial stage hypertrophy, develops into mammary duct ectasia from cyclomastopathy, be called adenosis of breast, be mainly in 30 ~ 45 years old, Symptoms is serious, belongs to cyclomastopathy II phase.Easily draw attention, often cure more difficult, obstinate causes depression, causes exacerbation of symptoms.Seriously cause endocrine regulation, the serial reaction such as dark and gloomy in menoxenia, insomnia and dreamful sleep, the colour of skin; (mammary duct ectasia merges epithelial hyperplasia disease to cystic hyperplasia, III phase cyclomastopathy) be further developing of mammary gland second phase hypertrophy, mostly occur at 40 ~ 55 years old, Symptoms is very serious, the rate that cancerates of three phase hypertrophy is more than 70%, and three phase cyclomastopathy often bring depression and the feared state of mind to patient.
Therefore, the medicine of research and development effective treatment cyclomastopathy is very necessary.
Summary of the invention
The object of the present invention is to provide a kind of pharmaceutical composition for the treatment of cyclomastopathy and its production and use.
The invention provides a kind of pharmaceutical composition for the treatment of cyclomastopathy, it is the preparation be prepared from by the crude drug of following weight proportion:
The Radix Angelicae Dahuricae 5 ~ 15 parts, Radix Bupleuri 1 ~ 11 part, Rhizoma Atractylodis Macrocephalae (parched) 10 ~ 20 parts, Radix Angelicae Sinensis 1 ~ 11 part, Concha Ostreae (calcined) 15 ~ 25 parts, Rhizoma Curcumae 3 ~ 13 parts, 10 ~ 20 parts, Poria, Ramulus Cinnamomi 1 ~ 11 part, Sargassum 7 ~ 17 parts, Cortex Magnoliae Officinalis 5 ~ 15 parts, the Radix Astragali 7 ~ 17 parts, Herba Pogostemonis 3 ~ 13 parts, Semen Citri Reticulatae 5 ~ 15 parts, Thallus Laminariae (Thallus Eckloniae) 7 ~ 17 parts, Radix Gentianae 1 ~ 9 part, Myrrha 1 ~ 9 part, Olibanum 1 ~ 5 part, Rhizoma Sparganii 3 ~ 13 parts, Rhizoma Cimicifugae 1 ~ 9 part, water tinctorius seed 10 ~ 20 parts, Hirudo 1 ~ 7 part, Retinervus Luffae Fructus 10 ~ 20 parts, 3 ~ 13 parts, Semen Persicae, Folium Stevlae Rebaudianae 5 ~ 15 parts, Oletum Trogopterori 1 ~ 11 part, Spica Prunellae 3 ~ 13 parts, Radix Scrophulariae 10 ~ 20 parts, Sanguis Draxonis 1 ~ 5 part, Bulbus Fritillariae Thunbergii 7 ~ 17 parts.
Preferably, it is the preparation be prepared from by the crude drug of following weight proportion: the Radix Angelicae Dahuricae 7 ~ 13 parts, Radix Bupleuri 3 ~ 9 parts, Rhizoma Atractylodis Macrocephalae (parched) 12 ~ 18 parts, Radix Angelicae Sinensis 3 ~ 9 parts, Concha Ostreae (calcined) 17 ~ 23 parts, Rhizoma Curcumae 5 ~ 11 parts, 12 ~ 18 parts, Poria, Ramulus Cinnamomi 3 ~ 9 parts, Sargassum 9 ~ 15 parts, Cortex Magnoliae Officinalis 7 ~ 13 parts, the Radix Astragali 9 ~ 15 parts, Herba Pogostemonis 5 ~ 11 parts, Semen Citri Reticulatae 7 ~ 13 parts, Thallus Laminariae (Thallus Eckloniae) 9 ~ 15 parts, Radix Gentianae 2 ~ 8 parts, Myrrha 2 ~ 8 parts, Olibanum 2 ~ 4 parts, Rhizoma Sparganii 5 ~ 11 parts, Rhizoma Cimicifugae 2 ~ 8 parts, water tinctorius seed 12 ~ 18 parts, Hirudo 2 ~ 6 parts, Retinervus Luffae Fructus 12 ~ 18 parts, 5 ~ 11 parts, Semen Persicae, Folium Stevlae Rebaudianae 7 ~ 13 parts, Oletum Trogopterori 3 ~ 9 parts, Spica Prunellae 5 ~ 11 parts, Radix Scrophulariae 12 ~ 18 parts, Sanguis Draxonis 2 ~ 4 parts, Bulbus Fritillariae Thunbergii 9 ~ 15 parts.
Further preferably, it is the preparation be prepared from by the crude drug of following weight proportion: the Radix Angelicae Dahuricae 10 parts, Radix Bupleuri 6 parts, Rhizoma Atractylodis Macrocephalae (parched) 15 parts, Radix Angelicae Sinensis 6 parts, Concha Ostreae (calcined) 20 parts, Rhizoma Curcumae 8 parts, 15 parts, Poria, Ramulus Cinnamomi 6 parts, Sargassum 12 parts, Cortex Magnoliae Officinalis 10 parts, the Radix Astragali 12 parts, Herba Pogostemonis 8 parts, Semen Citri Reticulatae 10 parts, Thallus Laminariae (Thallus Eckloniae) 12 parts, Radix Gentianae 5 parts, Myrrha 5 parts, Olibanum 3 parts, Rhizoma Sparganii 8 parts, Rhizoma Cimicifugae 5 parts, water tinctorius seed 15 parts, Hirudo 4 parts, Retinervus Luffae Fructus 15 parts, 8 parts, Semen Persicae, Folium Stevlae Rebaudianae 10 parts, Oletum Trogopterori 6 parts, Spica Prunellae 8 parts, Radix Scrophulariae 15 parts, Sanguis Draxonis 3 parts, Bulbus Fritillariae Thunbergii 12 parts.
Wherein, described preparation be by the medicated powder of each crude drug, the water of crude drug or/and ethanol extraction is active component, to add in pharmacy or health product the preparation that conventional adjuvant or complementary composition are prepared from.
Further, described preparation is oral formulations.
Further, described oral liquid, granule, capsule, unguentum, pill, medicinal tea, tablet or powder.
Present invention also offers the preparation method of aforementioned pharmaceutical compositions, it comprises the steps:
(1) each crude drug is taken by weight ratio;
(2) each crude drug directly pulverized or add water or/and after ethanol extraction, adding adjuvant conventional in pharmacy or complementary composition, be prepared into conventional preparation, obtain final product.
Present invention also offers the purposes of aforementioned pharmaceutical compositions in the medicine of preparation treatment cyclomastopathy.
Wherein, described medicine is the medicine for the treatment of cyclomastopathy, adenosis of breast or cystic hyperplasia.
Wherein, described medicine is the medicine of the smooth and/or susceptible to lose temper due to restlessness for the treatment of mastalgia, lump in breast, nipple discharge, menoxenia, feelings will.In we, the water tinctorius seed blood that falls apart disappears abdominal mass, and removing food stagnancy pain relieving, inducing diuresis to remove edema, Yong Yu mass in the abdomen mass in the abdomen, goiter, inducing diuresis to remove edema thinks monarch drug.Thallus Laminariae (Thallus Eckloniae), Sargassum, Concha Ostreae (calcined) hard masses softening and resolving, kind solution goiter, scrofula carbuncle; Spica Prunellae mass dissipating and swelling eliminating, for acute mastitis, nodules of the breast, distending pain of the breast, above is ministerial drug altogether.The Rhizoma Atractylodis Macrocephalae, Poria, Cortex Magnoliae Officinalis, Herba Pogostemonis, Radix Gentianae diuretic remove dry, to separate endogenous dampness; Hirudo, Retinervus Luffae Fructus dredge the meridian passage, eliminate airsetting stasis; Radix Bupleuri elevate a turnable ladder, priming is to human upper; The Radix Angelicae Dahuricae, astragalus swell dispersing pain relieving, alleviate the pain that cyclomastopathy causes; Radix Angelicae Sinensis, Rhizoma Curcumae, Ramulus Cinnamomi, Olibanum, Myrrha, Rhizoma Sparganii, Semen Persicae, Oletum Trogopterori, Sanguis Draxonis promoting blood circulation to remove blood stasis, promote that hypertrophy position is recovered; Semen Citri Reticulatae, Radix Scrophulariae, Bulbus Fritillariae Thunbergii detoxicating and resolving stagnation of pathogens, to eliminate the lump formed in cyclomastopathy; Folium Stevlae Rebaudianae mediation flavour of a drug, above each taste medicine is adjuvant drug altogether.Rhizoma Cimicifugae has the effect of elevate a turnable ladder, makes to make medicine in the up side of being of drug effect.
The symptom that pharmaceutical composition of the present invention effectively can alleviate mastalgia, lump in breast, nipple discharge, menoxenia, feelings will change cyclomastopathy such as (feelings will smooth, susceptible to lose temper due to restlessness), effective percentage is high, I phase cyclomastopathy, II phase cyclomastopathy and III phase cyclomastopathy can be treated, provide a kind of new medicament selection for clinical.
Obviously, according to foregoing of the present invention, according to ordinary technical knowledge and the customary means of this area, not departing under the present invention's above-mentioned basic fundamental thought prerequisite, the amendment of other various ways, replacement or change can also be made.
The detailed description of the invention of form by the following examples, is described in further detail foregoing of the present invention again.But this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following example.All technology realized based on foregoing of the present invention all belong to scope of the present invention.
Detailed description of the invention
The preparation of embodiment 1 present composition
Radix Angelicae Dahuricae 10g, Radix Bupleuri 6g, Rhizoma Atractylodis Macrocephalae (parched) 15g, Radix Angelicae Sinensis 6g, Concha Ostreae (calcined) 20g, Rhizoma Curcumae 8g, Poria 15g, Ramulus Cinnamomi 6g, Sargassum 12g, Cortex Magnoliae Officinalis 10g, Radix Astragali 12g, Herba Pogostemonis 8g, Semen Citri Reticulatae 10g, Thallus Laminariae (Thallus Eckloniae) 12g, Radix Gentianae 5g, Myrrha 5g, Olibanum 3g, Rhizoma Sparganii 8g, Rhizoma Cimicifugae 5g, water tinctorius seed 15g, Hirudo 4g, Retinervus Luffae Fructus 15g, Semen Persicae 8g, Folium Stevlae Rebaudianae 10g, Oletum Trogopterori 6g, Spica Prunellae 8g, Radix Scrophulariae 15g, Sanguis Draxonis 3g, Bulbus Fritillariae Thunbergii 12g.
Get above-mentioned raw materials medicine, decoct with water 3 times, decoct 30min at every turn, merge decocting liquid, obtain decoction.
The preparation of embodiment 2 present composition
Radix Angelicae Dahuricae 7g, Radix Bupleuri 3g, Rhizoma Atractylodis Macrocephalae (parched) 12g, Radix Angelicae Sinensis 3g, Concha Ostreae (calcined) 17g, Rhizoma Curcumae 5g, Poria 12g, Ramulus Cinnamomi 3g, Sargassum 9g, Cortex Magnoliae Officinalis 7 ~ 13g, Radix Astragali 9g, Herba Pogostemonis 5g, Semen Citri Reticulatae 7g, Thallus Laminariae (Thallus Eckloniae) 9g, Radix Gentianae 2g, Myrrha 2g, Olibanum 2g, Rhizoma Sparganii 5g, Rhizoma Cimicifugae 2g, water tinctorius seed 12g, Hirudo 2g, Retinervus Luffae Fructus 12g, Semen Persicae 5g, Folium Stevlae Rebaudianae 7g, Oletum Trogopterori 3g, Spica Prunellae 5g, Radix Scrophulariae 12g, Sanguis Draxonis 2g, Bulbus Fritillariae Thunbergii 9g.
Get above-mentioned raw materials medicine, by each component crushed after being dried, sieve gets the medicated powder of certain particle size, makes bag tea agent or powder, every packed amount 2g after mix homogeneously.
The preparation of embodiment 3 present composition
Get crude drug: Radix Angelicae Dahuricae 13g, Radix Bupleuri 9g, Rhizoma Atractylodis Macrocephalae (parched) 18g, Radix Angelicae Sinensis 9g, Concha Ostreae (calcined) 23g, Rhizoma Curcumae 11g, Poria 18g, Ramulus Cinnamomi 9g, Sargassum 15g, Cortex Magnoliae Officinalis 13g, Radix Astragali 15g, Herba Pogostemonis 11g, Semen Citri Reticulatae 13g, Thallus Laminariae (Thallus Eckloniae) 15g, Radix Gentianae 8g, Myrrha 8g, Olibanum 4g, Rhizoma Sparganii 11g, Rhizoma Cimicifugae 8g, water tinctorius seed 18g, Hirudo 6g, Retinervus Luffae Fructus 18g, Semen Persicae 11g, Folium Stevlae Rebaudianae 13g, Oletum Trogopterori 9g, Spica Prunellae 11g, Radix Scrophulariae 18g, Sanguis Draxonis 4g, Bulbus Fritillariae Thunbergii 15g.
Get above-mentioned raw materials medicine, decoct with water 3 times, decoct 30min at every turn, merge decocting liquid, concentrated, leave standstill, get supernatant, reconcentration, add appropriate amount of auxiliary materials, prepare unguentum, oral liquid or syrup.
The preparation of embodiment 4 present composition
Get crude drug: Radix Angelicae Dahuricae 5g, Radix Bupleuri 1g, Rhizoma Atractylodis Macrocephalae (parched) 10g, Radix Angelicae Sinensis 1g, Concha Ostreae (calcined) 15g, Rhizoma Curcumae 3g, Poria 10g, Ramulus Cinnamomi 1g, Sargassum 7g, Cortex Magnoliae Officinalis 5g, Radix Astragali 7g, Herba Pogostemonis 3g, Semen Citri Reticulatae 5g, Thallus Laminariae (Thallus Eckloniae) 7g, Radix Gentianae 1g, Myrrha 1g, Olibanum 1g, Rhizoma Sparganii 3g, Rhizoma Cimicifugae 1g, water tinctorius seed 10g, Hirudo 1g, Retinervus Luffae Fructus 10g, Semen Persicae 3g, Folium Stevlae Rebaudianae 5g, Oletum Trogopterori 1g, Spica Prunellae 3g, Radix Scrophulariae 10g, Sanguis Draxonis 1g, Bulbus Fritillariae Thunbergii 7g.
Get above-mentioned raw materials medicine, first use 75% alcohol reflux 2 times, collect alcohol extract, medicinal residues decoct with water 2 times again, merge decocting liquid, after alcohol extract is reclaimed ethanol, mix with decocting liquid, concentrated, add appropriate amount of auxiliary materials and prepare granule, tablet or capsule.
The preparation of embodiment 5 present composition
Get crude drug Radix Angelicae Dahuricae 15g, Radix Bupleuri 11g, Rhizoma Atractylodis Macrocephalae (parched) 20g, Radix Angelicae Sinensis 11g, Concha Ostreae (calcined) 25g, Rhizoma Curcumae 13g, Poria 20g, Ramulus Cinnamomi 11g, Sargassum 17g, Cortex Magnoliae Officinalis 15g, Radix Astragali 17g, Herba Pogostemonis 13g, Semen Citri Reticulatae 15g, Thallus Laminariae (Thallus Eckloniae) 17g, Radix Gentianae 9g, Myrrha 9g, Olibanum 5g, Rhizoma Sparganii 13g, Rhizoma Cimicifugae 9g, water tinctorius seed 20g, Hirudo 7g, Retinervus Luffae Fructus 20g, Semen Persicae 13g, Folium Stevlae Rebaudianae 15g, Oletum Trogopterori 11g, Spica Prunellae 13g, Radix Scrophulariae 20g, Sanguis Draxonis 5g, Bulbus Fritillariae Thunbergii 17g.
Get above-mentioned raw materials medicine, decoct with water 3 times, merge decocting liquid, concentrated, add appropriate amount of auxiliary materials and prepare buccal tablet.
Beneficial effect of the present invention is proved below by way of concrete pharmacodynamics test.
Test example 1 pharmaceutical composition of the present invention is to the therapeutical effect of cyclomastopathy
Accept standard for medical treatment: accept for medical treatment through diagnosis be I phase cyclomastopathy, II phase cyclomastopathy, III phase cyclomastopathy patient 238 example.The symptom that patient may occur comprises mastalgia, lump in breast, nipple discharge, menoxenia, feelings will change (feelings will smooth, susceptible to lose temper due to restlessness).
Therapeutic Method: use decoction prepared by the embodiment of the present invention 1, daily 2 times, each 20ml concentrated solution, every 1ml concentrated solution is equivalent to 1.6g raw medicinal herbs, treatment time 15-30 days.
Therapeutic outcome:
Table 1
Table 2
Table 3
Table 4
Table 5
Experimental result explanation, the symptom that pharmaceutical composition of the present invention effectively can alleviate mastalgia, lump in breast, nipple discharge, menoxenia, feelings will change cyclomastopathy such as (feelings will smooth, susceptible to lose temper due to restlessness), effective percentage is high, can treat I phase cyclomastopathy, II phase cyclomastopathy and III phase cyclomastopathy, potential applicability in clinical practice is good.
Claims (10)
1. treat a pharmaceutical composition for cyclomastopathy, it is characterized in that: it is the preparation that the crude drug comprising following weight proportion is prepared from:
The Radix Angelicae Dahuricae 5 ~ 15 parts, Radix Bupleuri 1 ~ 11 part, Rhizoma Atractylodis Macrocephalae (parched) 10 ~ 20 parts, Radix Angelicae Sinensis 1 ~ 11 part, Concha Ostreae (calcined) 15 ~ 25 parts, Rhizoma Curcumae 3 ~ 13 parts, 10 ~ 20 parts, Poria, Ramulus Cinnamomi 1 ~ 11 part, Sargassum 7 ~ 17 parts, Cortex Magnoliae Officinalis 5 ~ 15 parts, the Radix Astragali 7 ~ 17 parts, Herba Pogostemonis 3 ~ 13 parts, Semen Citri Reticulatae 5 ~ 15 parts, Thallus Laminariae (Thallus Eckloniae) 7 ~ 17 parts, Radix Gentianae 1 ~ 9 part, Myrrha 1 ~ 9 part, Olibanum 1 ~ 5 part, Rhizoma Sparganii 3 ~ 13 parts, Rhizoma Cimicifugae 1 ~ 9 part, water tinctorius seed 10 ~ 20 parts, Hirudo 1 ~ 7 part, Retinervus Luffae Fructus 10 ~ 20 parts, 3 ~ 13 parts, Semen Persicae, Folium Stevlae Rebaudianae 5 ~ 15 parts, Oletum Trogopterori 1 ~ 11 part, Spica Prunellae 3 ~ 13 parts, Radix Scrophulariae 10 ~ 20 parts, Sanguis Draxonis 1 ~ 5 part, Bulbus Fritillariae Thunbergii 7 ~ 17 parts.
2. pharmaceutical composition according to claim 1, is characterized in that: it is the preparation be prepared from by the crude drug of following weight proportion:
The Radix Angelicae Dahuricae 7 ~ 13 parts, Radix Bupleuri 3 ~ 9 parts, Rhizoma Atractylodis Macrocephalae (parched) 12 ~ 18 parts, Radix Angelicae Sinensis 3 ~ 9 parts, Concha Ostreae (calcined) 17 ~ 23 parts, Rhizoma Curcumae 5 ~ 11 parts, 12 ~ 18 parts, Poria, Ramulus Cinnamomi 3 ~ 9 parts, Sargassum 9 ~ 15 parts, Cortex Magnoliae Officinalis 7 ~ 13 parts, the Radix Astragali 9 ~ 15 parts, Herba Pogostemonis 5 ~ 11 parts, Semen Citri Reticulatae 7 ~ 13 parts, Thallus Laminariae (Thallus Eckloniae) 9 ~ 15 parts, Radix Gentianae 2 ~ 8 parts, Myrrha 2 ~ 8 parts, Olibanum 2 ~ 4 parts, Rhizoma Sparganii 5 ~ 11 parts, Rhizoma Cimicifugae 2 ~ 8 parts, water tinctorius seed 12 ~ 18 parts, Hirudo 2 ~ 6 parts, Retinervus Luffae Fructus 12 ~ 18 parts, 5 ~ 11 parts, Semen Persicae, Folium Stevlae Rebaudianae 7 ~ 13 parts, Oletum Trogopterori 3 ~ 9 parts, Spica Prunellae 5 ~ 11 parts, Radix Scrophulariae 12 ~ 18 parts, Sanguis Draxonis 2 ~ 4 parts, Bulbus Fritillariae Thunbergii 9 ~ 15 parts.
3. pharmaceutical composition according to claim 2, it is characterized in that: it is the preparation be prepared from by the crude drug of following weight proportion: the Radix Angelicae Dahuricae 10 parts, Radix Bupleuri 6 parts, Rhizoma Atractylodis Macrocephalae (parched) 15 parts, Radix Angelicae Sinensis 6 parts, Concha Ostreae (calcined) 20 parts, Rhizoma Curcumae 8 parts, 15 parts, Poria, Ramulus Cinnamomi 6 parts, Sargassum 12 parts, Cortex Magnoliae Officinalis 10 parts, the Radix Astragali 12 parts, Herba Pogostemonis 8 parts, Semen Citri Reticulatae 10 parts, Thallus Laminariae (Thallus Eckloniae) 12 parts, Radix Gentianae 5 parts, Myrrha 5 parts, Olibanum 3 parts, Rhizoma Sparganii 8 parts, Rhizoma Cimicifugae 5 parts, water tinctorius seed 15 parts, Hirudo 4 parts, Retinervus Luffae Fructus 15 parts, 8 parts, Semen Persicae, Folium Stevlae Rebaudianae 10 parts, Oletum Trogopterori 6 parts, Spica Prunellae 8 parts, Radix Scrophulariae 15 parts, Sanguis Draxonis 3 parts, Bulbus Fritillariae Thunbergii 12 parts.
4. the pharmaceutical composition according to claims 1 to 3 any one, it is characterized in that: it be by the medicated powder of each crude drug, the water of crude drug or/and ethanol extraction is active component, to add in pharmacy or health product the preparation that conventional adjuvant or complementary composition are prepared from.
5. the pharmaceutical composition according to Claims 1 to 4 any one, is characterized in that: described preparation is oral formulations.
6. pharmaceutical composition according to claim 5, is characterized in that: described oral formulations is oral liquid, granule, capsule, unguentum, pill, tablet, medicinal tea or powder.
7. the preparation method of pharmaceutical composition described in claim 1 ~ 6 any one, is characterized in that: it comprises the steps:
(1) each crude drug is taken by weight ratio;
(2) each crude drug directly pulverized or add water or/and after ethanol extraction, adding adjuvant conventional in pharmacy or complementary composition, be prepared into conventional preparation.
8. the purposes of pharmaceutical composition described in claim 1 ~ 6 any one in the medicine of preparation treatment cyclomastopathy.
9. purposes according to claim 8, is characterized in that: described medicine is the medicine for the treatment of cyclomastopathy, adenosis of breast or cystic hyperplasia.
10. purposes according to claim 8 or claim 9, is characterized in that: described medicine is the medicine of the smooth and/or susceptible to lose temper due to restlessness for the treatment of mastalgia, lump in breast, nipple discharge, menoxenia, feelings will.
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| CN105920545A (en) * | 2016-06-29 | 2016-09-07 | 唐会杰 | Chinese medicinal composition for treating breast hyperplasia and preparation method thereof |
| CN106729370A (en) * | 2016-12-05 | 2017-05-31 | 通渭县中医医院 | A kind of Chinese medicine composition for treating Chong and Ren channel disorder type mastoproliferation |
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| CN106692689A (en) * | 2017-03-10 | 2017-05-24 | 通渭县中医医院 | Traditional Chinese medicine composition for treating intermin-gled phlegm and blood stasis type mammary gland hyperplasia |
| CN106943572A (en) * | 2017-03-31 | 2017-07-14 | 上海世道健康科技有限公司 | It is a kind of to treat Chinese medicine composition of Cystic hyperplasia breast and preparation method thereof |
| CN108404095A (en) * | 2018-05-24 | 2018-08-17 | 福州鑫美源生物医药工程有限公司 | A kind of Chinese medicine transdermal patch promoting blood circulation and removing obstruction in channels for curing mammary gland hyperplasia |
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