CN103479817A - Wound healing gel - Google Patents
Wound healing gel Download PDFInfo
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- CN103479817A CN103479817A CN201310468409.1A CN201310468409A CN103479817A CN 103479817 A CN103479817 A CN 103479817A CN 201310468409 A CN201310468409 A CN 201310468409A CN 103479817 A CN103479817 A CN 103479817A
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Abstract
The invention discloses a wound healing gel. The wound healing gel comprises the following components by weight: 30-40 parts of erythromycin, 3-10 parts a phellodendron extractive, 5-10 parts of a rhubarb extractive, 2-5 parts of a mulberry leaf extractive, 5-10 parts of an Aloe vera extractive, 10-20 parts of carbomer, 2-5 parts of triethanolamine, 3-6 parts of polyvinyl pyrrolidone and 15-20 parts of glycerol. The gel provided by the invention has efficacies of heat clearing, detoxifying, cooling, refreshing, relieving pain, removing slough, promoting growth of tissue regeneration, astringing wound, reducing postoperative wound infection and postoperative complications, can treat trauma and wound infections. The gel has the advantages of easiness for absorption, good curative effect, no scar, simple processing method, no toxic or side effect, simple and practicable preparation technology, cheap and abundant drug sources, low cost and high benefits.
Description
Technical field
The present invention relates to a kind of gel, particularly a kind of wound healing gel, belong to field of medicaments.
Background technology
At present for exogenous injury of human body for example get injured by a fall, the means of therapeutic wound healing after knife injury or surgical operation are generally: adopt medicine or medicinal dressing adhesive plaster, medicament categories is a lot, mostly be Western medicine, usually contain hormone in Western medicine, once inappropriate medication, may cause wound infection, develop complications or drug dependence, and may leave cicatrix after healing.The medicinal dressing adhesive plaster is slower to therapeutic wound healing, and there will be allergic phenomena, to the scar removal after the wound wound healing without positive effect.
The drug gel energy long period with the site of action tight adhesion, bioadhesive is preferably arranged, method for making is simple, uses comfortablely, biocompatibility is good, easily absorbs.
Summary of the invention
The problem existed for prior art the invention provides a kind of wound healing gel.
The technical solution that realizes the object of the invention is: a kind of wound healing gel comprises that following parts by weight of component forms: erythromycin 30-40 part, Cortex Phellodendri extract 3-10 part, Radix Et Rhizoma Rhei extract 5-10 part, Folium Mori extract 2-5 part, aloe vera extract 5-10 part, carbomer 10-20 part, triethanolamine 2-5 part, polyvinylpyrrolidone 3-6 part, glycerol 15-20 part.
Preparation technology is as follows:
1. carbomer is added in glycerol and is ground to moisture state, add distilled water to grind again;
2. polyvinylpyrrolidone, triethanolamine are added distilled water to make it to dissolve, then be placed in first step mixture and stir and make it gel;
3. the mixed solution of erythromycin, Cortex Phellodendri extract, Radix Et Rhizoma Rhei extract, Folium Mori extract, aloe vera extract is joined in coagulant liquid and stirs and get final product.
The mechanism of action of the present invention is as follows:
Erythromycin: these product have broad-spectrum antibacterial action, to sensitive organism comprise streptococcus pneumoniae, streptococcus, part staphylococcus, anthrax bacillus, clostridium tetani, to mycoplasma hyopneumoniae, chlamydia, spirillum, certain inhibitory action is also arranged.
Cortex Phellodendri extract: the Cortex Phellodendri antibiotic effective ingredient is berberine, thus its pharmacological action and Rhizoma Coptidis broadly similar, but content is low than Rhizoma Coptidis.In vitro tests to staphylococcus aureus, streptococcus pneumoniae, diphtheria corynebacterium, Streptococcus viridans, dysentery bacterium, Hemolytic streptococcus, meningococcus, vibrio cholera, anthrax bacillus all effectively or stronger inhibitory action arranged; Bacillus subtilis, bordetella pertussis, clostridium tetani are also had to inhibitory action.
Radix Et Rhizoma Rhei extract: for thrombocytopenia and hemostasis, antiinflammatory, responsive antibacterial is had to staphylococcus, Hemolytic streptococcus, micrococcus gonococcus, diphtheria corynebacterium, Bacillus typhi, dysentery bacterium etc.
Folium Mori extract: can remove interior free yl, make to be accumulated in human body interior toxin and refuse oxidized, increase the oxygen content in blood, enhance metabolism and microcirculation, can obviously extend activating part thromboplastin (APTI) time, thrombinogen (PT) time and thrombin (TT) time of the interior whole blood clotting time of Mice Body and significant prolongation plasma in rabbit.
Aloe vera extract: suppress the effect of arachidonic acid metabolic pathway performance anti-inflammatory by epoxidase, and can suppress wound and cicatrix occurs or eliminate cicatrix.
Carbomer: with tetramethylolmethane etc. and the crosslinked acrylic acid crosslinked resin obtained of acrylic acid, gel-type vehicle.
Triethanolamine: pH adjusting agent.
Polyvinylpyrrolidone: skin penetration enhancer.
Glycerol: the wetting agent of gel and wetting agent.
The present invention treats the outer gel that injures trauma infection contamination can fast and effeciently treat skin injury, there is heat-clearing and toxic substances removing, cool pain-alleviating, putrefaction-removing granulation-promoting, convergence wound surface, reduce the effects such as postoperative wound infection, minimizing post-operative complication, can treat the diseases such as wound, trauma infection contamination, easily absorb, good effect, preventing from scar, processing method is simple, without any side effects, preparation is simple, the medicine source is enriched inexpensive, and cost is low, high efficiency.
The specific embodiment
Embodiment 1
(1). raw material is prepared:
30 parts, erythromycin, 3 parts of Cortex Phellodendri extracts, 10 parts of Radix Et Rhizoma Rhei extracts, 2 parts of Folium Mori extracts, 5 parts of aloe vera extract, 10 parts of carbomers, 2 parts of triethanolamine, 6 parts of polyvinylpyrrolidones, 15 parts of glycerol.
Embodiment 2
40 parts, erythromycin, 6 parts of Cortex Phellodendri extracts, 5 parts of Radix Et Rhizoma Rhei extracts, 5 parts of Folium Mori extracts, 8 parts of aloe vera extract, 20 parts of carbomers, 5 parts of triethanolamine, 3 parts of polyvinylpyrrolidones, 20 parts of glycerol.
Embodiment 3
35 parts, erythromycin, 10 parts of Cortex Phellodendri extracts, 8 parts of Radix Et Rhizoma Rhei extracts, 4 parts of Folium Mori extracts, 10 parts of aloe vera extract, 16 parts of carbomers, 4 parts of triethanolamine, 4 parts of polyvinylpyrrolidones, 18 parts of glycerol.
(2). preparation process: press proportioning described in above-described embodiment 1-3;
1. carbomer is added in glycerol and is ground to moisture state, add distilled water to grind again;
2. polyvinylpyrrolidone, triethanolamine are added distilled water to make it to dissolve, then be placed in first step mixture and stir and make it gel;
3. the mixed solution of erythromycin, Cortex Phellodendri extract, Radix Et Rhizoma Rhei extract, Folium Mori extract, aloe vera extract is joined in coagulant liquid and stirs and get final product.
(3). the treatment observation of curative effect:
1, case is selected: experience various surgery stitching operations or get injured by a fall, patient's 100 examples such as knife injury, the age, wound site was in extremity, chest, abdominal part or cervical region between 15-60 year.
2, observation of curative effect: use described in embodiment 1-3 the gel of filling a prescription.
3, using method: adopt medical alcohol, medical hydrogen peroxide etc. to clean wound surface, and smear gel of the present invention on wound surface, to smear evenly clockwise or counterclockwise, until absorb, when inessential, do not need to adopt the gauze wrapping, within one day, smear 2-3 time, observe the wound healing situation, can smear gel according to the suitable increase of wound weight situation and count to every day 3-5 time, generally within 2-5 days, form a scab and heal, wound Scar eliminating medicine mistake in 15-20 days after surgery stitching operation.
Criterion of therapeutical effect: 2-3 day wound heals fully, without the healing person of cicatrix, is 25 examples; 3-4 day wound heals fully, without the healing person of cicatrix, is 48 examples; 4-5 day wound heals fully, without the healing person of cicatrix, is 27 examples.
In sum, gel of the present invention for the wound at all ages and classes stage and different human body position or surgical operation after the treatment healing of wound, its curative effect and the speed effect of curing are remarkable, and have the specially good effect of the scar do not stayed.
Claims (2)
1. a wound healing gel, is characterized in that comprising that following parts by weight of component forms: erythromycin 30-40 part, Cortex Phellodendri extract 3-10 part, Radix Et Rhizoma Rhei extract 5-10 part, Folium Mori extract 2-5 part, aloe vera extract 5-10 part, carbomer 10-20 part, triethanolamine 2-5 part, polyvinylpyrrolidone 3-6 part, glycerol 15-20 part.
2. wound healing gel according to claim 1 is characterized in that described gel preparation process is as follows:
Step 1, carbomer is added in glycerol and is ground to moisture state, add distilled water to grind again;
Step 2, add distilled water to make it to dissolve polyvinylpyrrolidone, triethanolamine, then be placed in first step mixture and stir and make it gel;
Step 3, the mixed solution of erythromycin, Cortex Phellodendri extract, Radix Et Rhizoma Rhei extract, Folium Mori extract, aloe vera extract is joined in coagulant liquid and stirs and get final product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310468409.1A CN103479817A (en) | 2013-10-09 | 2013-10-09 | Wound healing gel |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310468409.1A CN103479817A (en) | 2013-10-09 | 2013-10-09 | Wound healing gel |
Publications (1)
| Publication Number | Publication Date |
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| CN103479817A true CN103479817A (en) | 2014-01-01 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201310468409.1A Pending CN103479817A (en) | 2013-10-09 | 2013-10-09 | Wound healing gel |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105394292A (en) * | 2015-12-14 | 2016-03-16 | 福建农林大学 | Five-cereal germ jasmine tea and preparation method therefor |
| CN108853312A (en) * | 2018-09-25 | 2018-11-23 | 陕西天宇制药有限公司 | Lauromacrogol external-use gel and preparation method thereof |
| CN110354317A (en) * | 2019-08-22 | 2019-10-22 | 佛山市平创医疗科技有限公司 | A kind of preparation method of the preparation method embedding liquid and water-soluble human body lubricating fluid |
| EP4324471A1 (en) | 2022-08-15 | 2024-02-21 | Universitätsmedizin der Johannes Gutenberg-Universität Mainz | Compositions for use in the prevention or treatment of oral or dental disorders or dysfunctions |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101874846A (en) * | 2010-07-06 | 2010-11-03 | 浙江中医药大学 | Method for preparing cataplasm for treating soft tissue injury |
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2013
- 2013-10-09 CN CN201310468409.1A patent/CN103479817A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101874846A (en) * | 2010-07-06 | 2010-11-03 | 浙江中医药大学 | Method for preparing cataplasm for treating soft tissue injury |
Non-Patent Citations (3)
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| 刘勇: "大黄、黄柏治疗烧伤30例", 《实用中西医结合临床》 * |
| 卢继萍: "桑叶的药理作用概述", 《中国乡村医药杂志》 * |
| 钟志东等: "芦荟凝胶的制备及质量控制", 《中国医院药学杂志》 * |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105394292A (en) * | 2015-12-14 | 2016-03-16 | 福建农林大学 | Five-cereal germ jasmine tea and preparation method therefor |
| CN108853312A (en) * | 2018-09-25 | 2018-11-23 | 陕西天宇制药有限公司 | Lauromacrogol external-use gel and preparation method thereof |
| CN108853312B (en) * | 2018-09-25 | 2021-04-16 | 陕西天宇制药有限公司 | Polycinnamic alcohol external gel and preparation method thereof |
| CN110354317A (en) * | 2019-08-22 | 2019-10-22 | 佛山市平创医疗科技有限公司 | A kind of preparation method of the preparation method embedding liquid and water-soluble human body lubricating fluid |
| CN110354317B (en) * | 2019-08-22 | 2022-02-11 | 佛山市平创医疗科技有限公司 | Preparation method of embedding liquid and preparation method of water-soluble human body lubricating liquid |
| EP4324471A1 (en) | 2022-08-15 | 2024-02-21 | Universitätsmedizin der Johannes Gutenberg-Universität Mainz | Compositions for use in the prevention or treatment of oral or dental disorders or dysfunctions |
| WO2024037841A1 (en) | 2022-08-15 | 2024-02-22 | Universitätsmedizin Der Johannes Gutenberg-Universität Mainz | Compositions for use in the prevention or treatment of oral or dental disorders or dysfunctions |
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Application publication date: 20140101 |