CN103463444A - Traditional Chinese medicine composition for treating phlegm stagnation cross-resistance type acnes - Google Patents

Traditional Chinese medicine composition for treating phlegm stagnation cross-resistance type acnes Download PDF

Info

Publication number
CN103463444A
CN103463444A CN2013104354284A CN201310435428A CN103463444A CN 103463444 A CN103463444 A CN 103463444A CN 2013104354284 A CN2013104354284 A CN 2013104354284A CN 201310435428 A CN201310435428 A CN 201310435428A CN 103463444 A CN103463444 A CN 103463444A
Authority
CN
China
Prior art keywords
parts
chinese medicine
medicine composition
traditional chinese
blood
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CN2013104354284A
Other languages
Chinese (zh)
Other versions
CN103463444B (en
Inventor
徐新华
徐金荣
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Li Bairong
Zheng Shihua
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CN201310435428.4A priority Critical patent/CN103463444B/en
Publication of CN103463444A publication Critical patent/CN103463444A/en
Application granted granted Critical
Publication of CN103463444B publication Critical patent/CN103463444B/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Landscapes

  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention discloses a traditional Chinese medicine composition for treating phlegm stagnation cross-resistance type acnes. The traditional Chinese medicine composition is prepared from Japanese metaplexis pericarp, large flower glechoma longituba, rhizoma corydalis, camellia flowers, Chinese watermelon stems, orange peel, cassia twigs, edible tulips, glabrous sarcandra herb and pericarpium trichosanthis. The traditional Chinese medicine composition can be clinically used for treating phlegm stagnation cross-resistance type acnes.

Description

A kind of Chinese medicine composition for the treatment of expectorant stasis of blood interlocking type acne
Technical field
The invention belongs to technical field of Chinese medicines, especially relate to a kind of Chinese medicine composition for the treatment of expectorant stasis of blood interlocking type acne.
Background technology
The traditional Chinese medical science is with a long history to the understanding of acne." Plain Questions vital QI of the body connecting with natural QI opinion " piece of writing proposes acne first, says: " sweating is shown in wet, is give birth to Cuo ... exposure to the wind after sweating due to overstrain, and invasion of pathogenic cold is Zha, and strongly fragrant is Cuo "." General Treatise on the Cause and Symptoms of Diseases face Blisters time " also said: " face Blisters person, have wind heat gas to give birth to bleb on the meaning face, head as rice are large, and also as large as paddy, white person is." " Waike Zhengzong, Orthodox Manual of External Diseases rosacea caused by lung-wind rosacea the 81 " also have: " acne belong to lung, and the acne nose belongs to spleen, and always all heat in blood stasis can not be fallen apart.What is called have all in, outside shape is all, should the wonderful subsides of true monarch loosely adds Rhizoma Typhonii and apply it, Folii Eriobotryae Pill for oral administration, Radix Scutellariae lung heat clearing drink " record, and the side's of sentencing medicine.Treated expectorant stasis of blood interlocking type acne single western medicine therapy commonly used, but effect is not satisfactory in the past, draws through inventor's long-term practice, Chinese medicine is controlled expectorant stasis of blood interlocking type acne and is had better effect, obtains good effect.
Summary of the invention
The object of the present invention is to provide the Chinese medicine composition of the treatment expectorant stasis of blood interlocking type acne that a kind of therapeutic effect is good, effective percentage is high, human body is had no side effect.
The object of the present invention is achieved like this, according to Chinese medical theory, utilize the property of medicine of Chinese medicine uniqueness, adopt Pericarpium Metaplexis, Flos Caryophylli HUOXUEDAN, Rhizoma Corydalis, Flos Camelliae Japonicae, Caulis Benincasae, Pericarpium Citri Reticulatae, Ramulus Cinnamomi, Pseudobulbus Cremastrae Seu Pleiones, Herba Sarcandrae, the fruit-rind of Chinese trichosanthes according to certain compatibility requirement, through being processed into.
Prepare Chinese medicine composition of the present invention and make Pericarpium Metaplexis 20-40 part, Flos Caryophylli HUOXUEDAN 15-30 part, Rhizoma Corydalis 15-30 part, Flos Camelliae Japonicae 10-20 part, Caulis Benincasae 10-20 part, Pericarpium Citri Reticulatae 10-20 part, Ramulus Cinnamomi 10-20 part, Pseudobulbus Cremastrae Seu Pleiones 10-20 part, Herba Sarcandrae 10-20 part, fruit-rind of Chinese trichosanthes 10-15 part by following raw material medicaments.
Optimum weight part of traditional Chinese medicinal composition raw materials of the present invention is: 30 parts of Pericarpium Metaplexis, 20 parts of Flos Caryophylli HUOXUEDAN, 20 parts of Rhizoma Corydalis, 15 parts of Flos Camelliae Japonicae, 15 parts of Caulis Benincasaes, 15 parts of Pericarpium Citri Reticulataes, 15 parts of Ramulus Cinnamomi, 15 parts of Pseudobulbus Cremastrae Seu Pleioness, 15 parts of Herba Sarcandraes, 12 parts of the fruit-rinds of Chinese trichosanthes.
The pharmacological action of Chinese medicine of the present invention is as follows:
Pericarpium Metaplexis: sweet, hot, flat.Return lung, kidney channel.Removing heat from the lung and dissipating phlegm, the dissipating blood stasis hemostasis.Clinical in cough with copious phlegm, asthma, pertussis, measles without adequate eruption, traumatic injury, the diseases such as traumatic hemorrhage.
Flos Caryophylli HUOXUEDAN: hot, flat.Preventing phlegm from forming and stopping coughing, dissipating blood stasis.Clinical in the phlegm dyspnea of coughing, the diseases such as fracture.
Rhizoma Corydalis: acrid, bitter, warm.Return liver, stomach, the heart, lung, spleen channel.Invigorate blood circulation, dissipating blood stasis, regulate the flow of vital energy, pain relieving.For all pains of trusted subordinate's waist knee joint, menoxenia, traumatic injury etc.
Flos Camelliae Japonicae: sweet, bitter, hot, puckery, cool.Return liver, lung meridian.Cooling blood for hemostasis, detumescence dissipating blood stasis.For haematemesis, hemoptysis, have blood in stool, the diseases such as scald, traumatic injury.
Caulis Benincasae: bitter, cold.Return lung, Liver Channel.Removing heat from the lung and dissipating phlegm, dredge the meridian passage.For the cough due to lung-heat, articular instability, proctoptosis, the diseases such as scabies.
Pericarpium Citri Reticulatae: acrid, bitter, warm, return spleen, stomach, lung meridian.In regulating the flow of vital energy and adjusting, stopping nausea and vomiting by lowering the adverse flow of QI, drying dampness to eliminate phlegm.Full vexed for chest and diaphragm, abdominal distention, anorexia, vomiting etc.
Ramulus Cinnamomi: hot, sweet, warm, GUIXIN, lung, urinary bladder channel.The diaphoresis expelling pathogenic factors from muscles, promoting the flow of QI-blood by warming the meridian, supporing yang activating QI.For anemofrigid cold, congealing cold with blood stasis, phlegm retention, syndrome of water-retention.
Pseudobulbus Cremastrae Seu Pleiones: sweet, micro-suffering, cold in nature.Return liver, stomach, lung meridian.Heat-clearing and toxic substances removing, dispersing swelling and dissipating binds.For the carbuncle malignant boil, scrofula tuberculosis, pharyngalgia sore throat, Serpentis, insect bite wound etc.
Herba Sarcandrae: hardship, the heart, flat.GUIXIN, Liver Channel.Expelling wind and removing dampness, promoting blood circulation to remove blood stasis, heat-clearing and toxic substances removing.For numb limbs and tense tendons, traumatic injury, fracture, dysmenorrhes, the stagnant stomachache of the stasis of blood in puerperal, pneumonia, appendicitis, acute gastroenteritis, bacillary dysentery, cholecystitis, abscess, stomatitis, rheumatic arthralgia etc.
The fruit-rind of Chinese trichosanthes: sweet, bitter, cold.Attach to the lung and stomach meridians.Removing heat from the lung and dissipating phlegm, the promoting the circulation of QI relieving stuffiness of the chest by dispersing aggregation of pathogens.For the cough due to lung-heat, breast side of body painful abdominal mass pain, laryngopharynx swelling and pain, the diseases such as nodules of the breast acute mastitis.
The most course of disease of patient is longer, outbreak repeatedly, protracted course of disease, the many stasis of bloods of prolonged illness.Or of a specified duration dysfunction of the spleen in transportation due to illness, water is wet to be stopped gathering for expectorant; Or, because of lung stomach accumulated heat, accumulate for a long time puzzledly, and make and to wet into expectorant, expectorant and the blood knot of fighting, phlegm and blood stasis amasss in face and forms various intractable acnes.In the present invention, Pericarpium Metaplexis reduces phlegm, dissipating blood stasis, hemostasis, Flos Caryophylli HUOXUEDAN reduce phlegm, dissipating blood stasis, Rhizoma Corydalis dissipating blood stasis, regulate the flow of vital energy, pain relieving, for monarch drug, Flos Camelliae Japonicae detumescence dissipating blood stasis, Caulis Benincasae reduces phlegm, dredge the meridian passage, the Pericarpium Citri Reticulatae sending down the abnormal ascending QI, reduce phlegm, Ramulus Cinnamomi promoting the flow of QI-blood by warming the meridian, Pseudobulbus Cremastrae Seu Pleiones heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, Herba Sarcandrae dissipating blood stasis, removing toxic substances, the fruit-rind of Chinese trichosanthes reduces phlegm, relieving stuffiness of the chest by dispersing aggregation of pathogens.Through clinical practice, find, expectorant stasis of blood interlocking type acne is had to unique curative effect, and all medicines are played the effect of heat-clearing and toxic substances removing, dissipating phlegm and resolving masses, eliminating stasis to stop pain altogether, reach the purpose for the treatment of expectorant stasis of blood interlocking type acne.
Chinese medicine composition of the present invention was in 2006 to 2012 clinical observation expectorant stasis of blood interlocking type acne 103 routine patients, and clinical report is as follows:
1, physical data
In 103 routine patients, age 17-48 year, the course of disease is many at 3 months to 1 year, 22 years old mean age.
2, diagnostic criteria.
2.1 " traditional Chinese medical science disease Standardization of diagnosis and curative effect " that diagnosis basis State Administration of Traditional Chinese Medicine issues:
1. the initial stage presents the red pimple of grain of rice size at follicular orifice, also can develop into pustule, after this can form hoary hair's acne or the blackhead of scleroma sample, and serious case can form scleroma property cyst;
2. be mainly in young men and women's adolescence, be distributed in face and chest and back, often with seborrhea;
3. have the thick greasy or exopathogen of eating and drinking without temperance, surfeit delicious food etc. to bring out more;
4. the women is many with menoxenia.
Clinical manifestation: face, thoracic dorsal have more tuberosity, pimple, cyst, cicatrix, or pigmentation, and the pimple color is dark, doublely see that xerostomia is vexed, insomnia and dreamful sleep, dry stool, body of the tongue purple or ecchymosis, yellow and thin fur, hesitant pulse or slow.
2.2 inclusive criteria:
1. 11~30 years old age; 2. meet the diagnostic criteria of homeliness type expectorant stasis of blood interlocking type acne; 3. observe in first 4 weeks and do not use the Chinese and western drugs relevant with primary disease; 4. the patient agrees to participate in voluntarily, and can coordinate clinical observation.
2.3 exclusion standard:
1. known to the Viaminate allergy sufferers; 2. enter to try the first 2 weeks once anti-expectorant stasis of blood interlocking type acne medicine persons such as external corticosteroid hormone, antibiotic; 3. enter to try first 4 weeks once oral corticosteroid hormone, gonadal hormone, antibiotic medicine persons; 4. gestation or women breast-feeding their children; 5. the occupational expectorant stasis of blood interlocking type acne due to chemical substance, drug-induced expectorant stasis of blood interlocking type acne.
3, Therapeutic Method
3.1 prescription: Pericarpium Metaplexis 30g, Flos Caryophylli HUOXUEDAN 20g, Rhizoma Corydalis 20g, Flos Camelliae Japonicae 15g, Caulis Benincasae 15g, Pericarpium Citri Reticulatae 15g, Ramulus Cinnamomi 15g, Pseudobulbus Cremastrae Seu Pleiones 15g, Herba Sarcandrae 15g, fruit-rind of Chinese trichosanthes 12g.
3.2 method of preparation and use: said medicine technique is routinely made decoction, 1 dose of every day, every day 2 times, within 7 days, is 1 course for the treatment of.
4, therapeutic outcome:
4.1 formulate with reference to " Chinese medicine Clinical Researches of New Drugs guideline ":
Recovery from illness: skin lesion extinction rate >=95%, or only leave over a little pigmentation, transference cure;
Produce effects: the skin lesion major part disappears, extinction rate 70%~95%, and symptom obviously alleviates;
Effectively: skin lesion partly disappears, extinction rate 50%~70%, doing well,improving;
Invalid: skin lesion disappears not obvious or increases the weight of, extinction rate<50%, and symptom has no variation.
4.2 result: in 103 routine patients, clinical cure 63 examples (61.2%), produce effects 21 examples (20.3%), 14 examples that take a turn for the better (13.6%), invalid 5 examples (4.9%), total effective rate is 95.1%.
Model case
1, Zhu, the man, 26 years old, the skin oil and fat secretion was vigorous, the intensive a plurality of pimple pustules of buccal section, forehead, lower jaw also have a little lesser tubercle, can extrude white lead color grease, suffer from constipation simultaneously, the symptoms such as mouth and nose drying, halitosis.Take medicine of the present invention, treat 2 courses for the treatment of, symptom obviously alleviates, and continues to take 2 courses for the treatment of, and recovery from illness is followed up a case by regular visits to after half a year without recurrence.
2, Lee, the female, 18 years old, acne 2 or three years, buccal acne point point, very the person has scleroma, and oral ulcer and gingival swelling and pain show effect repeatedly, hands and feet being not warm, easily perspire in face, back, the tastelessness poor appetite, abundant expectoration, urine is slightly yellow, constipation or loose stool, the soreness of waist is weak.Take medicine of the present invention, 1 dose of every day, after 2 courses for the treatment of, symptom is clearly better, and continues to take 3 courses for the treatment of, and recovery from illness is followed up a case by regular visits to after 1 year without recurrence.
3, Liu, the female, 23 years old, visible intensive, the granular cerise erythra of foxtail millet of two cheeks, with the pus point, part erythra place stays tuberosity and cicatrix, and facial pore is large, and that touches is greasy, and increase the weight of premenstruum.Take medicine of the present invention, treat 2 courses for the treatment of, symptom obviously alleviates, and continues to take 2 courses for the treatment of, and recovery from illness is followed up a case by regular visits to after half a year without recurrence.
The specific embodiment
Below in conjunction with embodiment, the present invention is further illustrated, and following this embodiment does not only limit the present invention for the present invention is described.
Embodiment 1, and a kind of Chinese medicine composition for the treatment of expectorant stasis of blood interlocking type acne is to be made by Pericarpium Metaplexis 20g, Flos Caryophylli HUOXUEDAN 15g, Rhizoma Corydalis 15g, Flos Camelliae Japonicae 10g, Caulis Benincasae 10g, Pericarpium Citri Reticulatae 10g, Ramulus Cinnamomi 10g, Pseudobulbus Cremastrae Seu Pleiones 10g, Herba Sarcandrae 10g, fruit-rind of Chinese trichosanthes 10g.
Embodiment 2, and a kind of Chinese medicine composition for the treatment of expectorant stasis of blood interlocking type acne is to be made by Pericarpium Metaplexis 30g, Flos Caryophylli HUOXUEDAN 20g, Rhizoma Corydalis 20g, Flos Camelliae Japonicae 15g, Caulis Benincasae 15g, Pericarpium Citri Reticulatae 15g, Ramulus Cinnamomi 15g, Pseudobulbus Cremastrae Seu Pleiones 15g, Herba Sarcandrae 15g, fruit-rind of Chinese trichosanthes 12g.
Embodiment 3, and a kind of Chinese medicine composition for the treatment of expectorant stasis of blood interlocking type acne is to be made by Pericarpium Metaplexis 40g, Flos Caryophylli HUOXUEDAN 30g, Rhizoma Corydalis 30g, Flos Camelliae Japonicae 20g, Caulis Benincasae 20g, Pericarpium Citri Reticulatae 20g, Ramulus Cinnamomi 20g, Pseudobulbus Cremastrae Seu Pleiones 20g, Herba Sarcandrae 20g, fruit-rind of Chinese trichosanthes 15g.

Claims (2)

1. a Chinese medicine composition for the treatment of expectorant stasis of blood interlocking type acne is characterized in that it is to be made by following raw material medicaments:
Pericarpium Metaplexis 20-40 part, Flos Caryophylli HUOXUEDAN 15-30 part, Rhizoma Corydalis 15-30 part, Flos Camelliae Japonicae 10-20 part, Caulis Benincasae 10-20 part, Pericarpium Citri Reticulatae 10-20 part, Ramulus Cinnamomi 10-20 part, Pseudobulbus Cremastrae Seu Pleiones 10-20 part, Herba Sarcandrae 10-20 part, fruit-rind of Chinese trichosanthes 10-15 part.
2. Chinese medicine composition according to claim 1 is characterized in that it is to be made by following raw material medicaments:
30 parts of Pericarpium Metaplexis, 20 parts of Flos Caryophylli HUOXUEDAN, 20 parts of Rhizoma Corydalis, 15 parts of Flos Camelliae Japonicae, 15 parts of Caulis Benincasaes, 15 parts of Pericarpium Citri Reticulataes, 15 parts of Ramulus Cinnamomi, 15 parts of Pseudobulbus Cremastrae Seu Pleioness, 15 parts of Herba Sarcandraes, 12 parts of the fruit-rinds of Chinese trichosanthes.
CN201310435428.4A 2013-09-14 2013-09-14 Traditional Chinese medicine composition for treating phlegm stagnation cross-resistance type acnes Expired - Fee Related CN103463444B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201310435428.4A CN103463444B (en) 2013-09-14 2013-09-14 Traditional Chinese medicine composition for treating phlegm stagnation cross-resistance type acnes

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201310435428.4A CN103463444B (en) 2013-09-14 2013-09-14 Traditional Chinese medicine composition for treating phlegm stagnation cross-resistance type acnes

Publications (2)

Publication Number Publication Date
CN103463444A true CN103463444A (en) 2013-12-25
CN103463444B CN103463444B (en) 2015-03-04

Family

ID=49788636

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201310435428.4A Expired - Fee Related CN103463444B (en) 2013-09-14 2013-09-14 Traditional Chinese medicine composition for treating phlegm stagnation cross-resistance type acnes

Country Status (1)

Country Link
CN (1) CN103463444B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106039179A (en) * 2016-07-19 2016-10-26 艾尼·图尔荪 Acne removal traditional Chinese medicinal preparation

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101259214A (en) * 2008-04-29 2008-09-10 王爱玲 Medicine for treating hyperplasia of mammary glands
CN103055116A (en) * 2012-11-25 2013-04-24 荣成市崖头美全口腔诊所 Traditional Chinese medicine composition for treating acnes

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101259214A (en) * 2008-04-29 2008-09-10 王爱玲 Medicine for treating hyperplasia of mammary glands
CN103055116A (en) * 2012-11-25 2013-04-24 荣成市崖头美全口腔诊所 Traditional Chinese medicine composition for treating acnes

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106039179A (en) * 2016-07-19 2016-10-26 艾尼·图尔荪 Acne removal traditional Chinese medicinal preparation

Also Published As

Publication number Publication date
CN103463444B (en) 2015-03-04

Similar Documents

Publication Publication Date Title
CN102743737B (en) Chinese medicinal preparation for effectively treating tracheitis
CN103142722B (en) Traditional Chinese medicine composition for treating liver qi depression type irregular menstruation
CN104721665A (en) Traditional Chinese medicine composition for treating cough and preparation method thereof
CN104840855A (en) Traditional Chinese medicine composition for treating pulmonary tuberculosis
CN103463444B (en) Traditional Chinese medicine composition for treating phlegm stagnation cross-resistance type acnes
CN103479968B (en) Traditional Chinese medicine composition for treating heart-fire flaming acne
CN103495130B (en) Traditional Chinese medicine composition for treating asthma
CN103550601B (en) Traditional Chinese medicine composition for treating kidney Yin deficiency type night sweats
CN103446483B (en) Traditional Chinese medicine composition for treating lung meridian wind-heat type acne
CN104107344A (en) Traditional Chinese medicine composition for treating chronic bronchitis
CN102552772B (en) Traditional Chinese medicine used for treating chronic cough lung deficiency
CN103494924B (en) Chinese medicine composition for treating damp-heat stagnation acne
CN102579607A (en) Chinese medicine composition for treating acne
CN102284035A (en) Chinese composition for treating rhinitis
CN103446370B (en) Traditional Chinese medicine composition for treating spleen-deficiency and phlegm-turbid stagnation type acne
CN104958653A (en) Traditional Chinese medicine composition for treating tuberculosis
CN105456617A (en) Oral-administrated traditional Chinese medicine pills for treating symptom of pathogenic fire derived from stagnation of liver and preparation method thereof
CN103385971A (en) Traditional Chinese medicine composition for treating acne
CN105250746A (en) Heat clearing and toxin removing oral liquid and preparation method thereof
CN104435133A (en) Medicament for reducing fever
CN103495050B (en) Chinese medicinal composition for treating blood-heat stasis type acne
CN102293888A (en) Chinese medicinal composition for treating syndrome characterized by dyspnea
CN106177550A (en) A kind of Chinese medicine composition treating wind disease dizziness
CN106166245A (en) A kind of Chinese medicine composition treating dizziness
CN104474176A (en) Traditional Chinese medicine preparation for treating spleen-deficiency and phlegm-damp type acne

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
ASS Succession or assignment of patent right

Owner name: ZHENG SHIHUA

Free format text: FORMER OWNER: XU XINHUA

Effective date: 20150123

Owner name: LI BAIRONG

Effective date: 20150123

C41 Transfer of patent application or patent right or utility model
C53 Correction of patent of invention or patent application
CB03 Change of inventor or designer information

Inventor after: Zheng Shihua

Inventor after: Li Bairong

Inventor before: Xu Xinhua

Inventor before: Xu Jinrong

COR Change of bibliographic data

Free format text: CORRECT: INVENTOR; FROM: XU XINHUA XU JINRONG TO: ZHENG SHIHUA LI BAIRONG

Free format text: CORRECT: ADDRESS; FROM: 262500 WEIFANG, SHANDONG PROVINCE TO: 262600 WEIFANG, SHANDONG PROVINCE

TA01 Transfer of patent application right

Effective date of registration: 20150123

Address after: 262600 Shandong County of Linqu Province Wang Shan Road No. 21 people's Hospital of Linqu County

Applicant after: Zheng Shihua

Applicant after: Li Bairong

Address before: 262500 Shandong province Qingzhou City Linglong Mountain Road No. 3888 Qingzhou Invalides hospital

Applicant before: Xu Xinhua

C14 Grant of patent or utility model
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20150304

Termination date: 20160914