CN103446329A - Application of tenuifolia-fructus forsythia soup to preparation of medicine for preventing and treating acute radiodermatitis - Google Patents
Application of tenuifolia-fructus forsythia soup to preparation of medicine for preventing and treating acute radiodermatitis Download PDFInfo
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Abstract
The invention relates to novel application of tenuifolia-fructus forsythia soup and particularly relates to application of tenuifolia-fructus forsythia soup to preparation of a medicine for preventing and treating acute radiodermatitis. According to the novel application, the tenuifolia-fructus forsythia soup can be used for preparing the orally-taken, externally-washing or externally-applied medicine for preventing and treating the acute radiodermatitis, the occurrence rate of the radiodermatitis can be prevented and reduced, refractory radiation ulcer is reduced, and the possibility of a subsequent skin cancer due to the long-term radiotherapy can be reduced. The tenuifolia-fructus forsythia soup has wide application prospect.
Description
Technical field
The present invention relates to the new purposes of Herba Schizonepetae Forsythiae Decoction, particularly relate to the purposes of Herba Schizonepetae Forsythiae Decoction for the preparation of the medicine of prevention and treatment acute radiodermatitis.
Background technology
The Herba Schizonepetae Forsythiae Decoction is that China is lost to one of ten Japanese large recipes.It is comprised of Herba Schizonepetae, Fructus Forsythiae, the Radix Angelicae Dahuricae, the Radix Rehmanniae, the Radix Paeoniae Alba, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Glycyrrhizae, Rhizoma Coptidis, Cortex Phellodendri, Fructus Gardeniae, Radix Scutellariae etc., has the effect of heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, promoting pus discharge and tissue regeneration strengthening.
Acute radiodermatitis is more common in the complication that radioactive accident and tumor radiotherapy cause, clinical manifestation be local skin erythema, edema, hemorrhage, rotten to the corn, transudate, infection are arranged, severe patient can form ulcer etc.Its dominant mechanism is after skin soft tissue is subject to radiation damage, histiocytic normal physiological metabolism changes, intracellular enzyme and chromosomal morphology and function all are affected, the local vascular inner membrance of the damaged edema that is inflamed, vessel wall thickening, tube chamber narrows down, even inaccessible, cause that local blood is for obstacle, histiocyte ischemic necrosis and form ulcer.
Acute radiodermatitis is common side reaction in the disease Patients During Radiotherapies such as tumor, incidence rate is high, approximately 87% radiotherapy patient there will be erythema and above radioactive skin reaction (edema, erosion, sepage, vesicle etc.) thereof, serious radiodermatitis can cause pain, cause part or systemic infection, form cicatrix, also can cause once in a while the radiotherapy interruption, thereby cause tumor control rate and cure rate to reduce.Generally research is found both at home and abroad, and acute radiation-induced skin ulcers has two large characteristics: the one, and impaired wound healing, show as the necrosis of repeatability ulcer; The 2nd, easily canceration at a specified future date.After the dermatoplastic treatment of being everlasting clinically healing, the retardance necrosis of subcutaneous tissue still occurring repeatedly, causes long-term ulcer wound surface not healed.Therefore setting up the effectively preventing measure seems particularly important.
At present, clinical useful bearing hydrocolloid dressing (Zhou Ping, bearing hydrocolloid dressing is applied to the routine clinical care of radiodermatitis 30, the Shandong nursing magazine, 2008, 14(19): 64-65), Moist ganze dressing (Zhang San's allusion quotation, Gao Yaoming, Lu Miaozhen etc., the clinical observations of liking III ° of radiodermatitis of skin treatment more, China's skin cypridology magazine, 2008, 22(9): 544-545), (Lu is quick for the compound recipe Oleum Radix Arnebiae (Oleum Radix Lithospermi), Xu Kai, Guo Ming, compound recipe Oleum Radix Arnebiae (Oleum Radix Lithospermi) treatment II-III degree radiodermatitis 32 examples, the Shaanxi traditional Chinese medical science, 2008, 29(5): 569-570), fresh aloe juice (Lin Zhiren, the above acute radiodermatitis observation of curative effect of fresh aloe juice treatment II degree, Shandong medicine, 2008, 61) 48(39): the report of local topical treating radiation dermatitis such as, obtained certain therapeutic effect.But, the treatment of acute radiodermatitis and radiation-induced skin ulcer is still lacked to economical and effective medicine.
Prevention of diseae's thought earns widespread respect in recent years, and the prevention of radiodermatitis too.There are some researches show, octin spray (Xie Weiying, Comparison of therapeutic and the analysis of octin spray prophylaxis of acute radiation skin injury, medicine and clinical, 2009, 16(23): 53-54), shielding medicine for skin (Guo Yonghong, Zhourong is big, the clinical observation of skin injury after the shielding medicine for skin preventive radiotherapy, practical clinical medicine, 2008, 9(9): 35-36), triethanolamine (Zhang Xiuping, Li Jian, Zhang Linde etc., the comparison to the acute radiodermatitis prevention of Trolamine cream and hydrophilic gel, Chinese Professional medical science, 2008, 35(3): 232-233) etc. can improve the toleration of patient to the acute radiation skin injury, reduce the degree of damage, postpone the time that damage occurs, play certain preventive effect.
The Chinese medicine prevention radiodermatitis has fragmentary report, but due to when design not according to the strict design of random, double blinding, contrast, curative effect need more research and determines.Chinese medicine to the main key issue of the current existence of research of this disease is: need on the basis of existing treatment, utilize modern science, means, the research comprehensively of multidisciplinary ground, form new method, new ideas, new demonstration that China more creates radiodermatitis ulcer characteristic, thereby widely popularize, the equipment of uses advanced and technology, systematically carry out the short Mechanism Study more of Chinese medicine, guiding clinical treatment again, and carry out on this basis the clinical evaluation method research of multicenter, large sample, randomized, double-blind, develop economy, convenience, efficient external therapy of Chinese herb novel formulation.
Summary of the invention
The object of the present invention is to provide the purposes of Herba Schizonepetae Forsythiae Decoction for the preparation of the medicine of prevention and treatment acute radiodermatitis.
According to purposes of the present invention, described Herba Schizonepetae Forsythiae Decoction can adopt the prescription of existing record, for example, traditional Chinese medical science ancient books " Wanbing Huichun, Curative Measures for All Diseases " is rolled up five record, perhaps the record of " the Wanbing Huichun, Curative Measures for All Diseases side " in Japan's " Chinese prescription diagnosis and treatment doctor allusion quotation ", mainly be comprised of the 17 flavor Chinese medicines such as Rhizoma Coptidis toxic materials clearing away decoction, SIWU TANG and Herba Schizonepetae, Fructus Forsythiae.
Preferably, described Herba Schizonepetae Forsythiae Decoction can adopt following Chinese medicine listed in specific embodiments of the invention to form: Herba Schizonepetae 10 grams, Fructus Forsythiae 20 grams, the Radix Angelicae Dahuricae 10 grams, the Radix Rehmanniae 15 grams, the Radix Paeoniae Alba 10 grams, Radix Angelicae Sinensis 20 grams, Rhizoma Chuanxiong 15 grams, Radix Glycyrrhizae 10 grams, Radix Bupleuri 24 grams, Radix Platycodonis 10 grams, Radix Saposhnikoviae 20 grams, Fructus Aurantii 10 grams, Herba Menthae 10 grams, Rhizoma Coptidis 15 grams, Cortex Phellodendri 20 grams, Fructus Gardeniae 15 grams, Radix Scutellariae 20 grams, symbiosis medicine 254 grams.
Because the Herba Schizonepetae Forsythiae Decoction can be used for taking orally originally, washout or external application, can be prepared as corresponding preparation.According to purposes of the present invention, that described Herba Schizonepetae Forsythiae Decoction also can be prepared as is for oral administration, the preparation of washout or external application.
Preferably, described Herba Schizonepetae Forsythiae Decoction is prepared as Wet-dressing agent, and its preparation method is: by crude drug totally 3 pairs respectively water boiling concentration become 5080ml, obtain 5% solution; Then 115 ℃, 15 minutes autoclavings, 4 ℃ of Refrigerator stores are standby; Each used time shakes up pours out in right amount, and water-bath is heated and used after 25 ℃.
The present invention, by the exploitation of the new purposes for the Herba Schizonepetae Forsythiae Decoction, can solve serious side reaction---the radiodermatitis of long-term puzzlement cancer patient radiotherapy, supports the patient to adhere to treatment.The cancer patient is numerous both at home and abroad, the radiation treatment common method, yet the incidence rate of radiodermatitis is very high, some patient even can't adhere to treatment because of the generation of dermatitis, cause the termination of therapeutic scheme and affect the treatment, therefore, the present invention, for the research and development of this class Protection Product, will have earthshaking meaning.
Apply the new purposes of Herba Schizonepetae Forsythiae Decoction of the present invention, be prepared into the prevention of oral administration, washout or external application and the medicine for the treatment of acute radiodermatitis, can prevent to reduce the incidence rate of radiodermatitis, reduce the generation of intractable radiation ulcer, also likely alleviate because of the skin carcinoma of long-term radiotherapy institute secondary may, have broad application prospects.
The accompanying drawing explanation
The schematic diagram that Fig. 1 is the swollen degree of foot measuring instrument.
Fig. 2 shows that difference prevents and treats the swollen degree situation of method different times rat biped foot.
Fig. 3 shows and respectively organizes different time Mus shank generation erythema situation.
Fig. 4 shows that rotten to the corn situation occurs respectively to organize different time Mus shank.
Fig. 5 shows and respectively organizes different time Mus shank generation sepage situation.
Fig. 6 shows and respectively organizes different time Mus shank generation ulcer situation.
Fig. 7 shows and respectively organizes different time Mus shank generation suppuration situation.
Fig. 8 shows and respectively organizes different time Mus shank observation index total mark situation.
The specific embodiment
The present invention selects the Herba Schizonepetae Forsythiae Decoction as drugs, set up rat acute radiation-induced skin ulcer model, observe the therapeutical effect of Herba Schizonepetae Forsythiae Decoction to acute radiodermatitis, estimate the curative effect of preventing and treating radiodermatitis of Herba Schizonepetae Forsythiae Decoction, and to lay early stage basic for developing new drug.
One, the preparation of preparation for the research of Herba Schizonepetae Forsythiae Decoction.
The present embodiment self-control Herba Schizonepetae Forsythiae Decoction Wet-dressing agent, its preparation method is: Herba Schizonepetae Forsythiae Decoction (Herba Schizonepetae 10 grams, Fructus Forsythiae 20 grams, the Radix Angelicae Dahuricae 10 grams, the Radix Rehmanniae 15 grams, the Radix Paeoniae Alba 10 grams, Radix Angelicae Sinensis 20 grams, Rhizoma Chuanxiong 15 grams, Radix Glycyrrhizae 10 grams, Radix Bupleuri 24 grams, Radix Platycodonis 10 grams, Radix Saposhnikoviae 20 grams, Fructus Aurantii 10 grams, Herba Menthae 10 grams, Rhizoma Coptidis 15 grams, Cortex Phellodendri 20 grams, Fructus Gardeniae 15 grams, Radix Scutellariae 20 grams), symbiosis medicine 254 grams, totally 3 pairs respectively water boiling concentration become 5080ml, obtain 5% solution.Then 115 ℃, 15 minutes autoclavings, 4 ℃ of Refrigerator stores are standby.Each used time shakes up pours out in right amount, and water-bath is heated and used after 25 ℃.
Two, the Herba Schizonepetae Forsythiae Decoction control radioactive curative effect of rat acute and scheme optimization research.
1, laboratory animal and grouping
Animal: 18 clean level female Wistar rats, body weight 250 ± 10 grams, provided by the Hospital of Southern Medical University animal center.
18 rats are divided into to 3 groups at random, 6 every group, are respectively A group (Herba Schizonepetae Forsythiae Decoction prophylactic treatment group), B group (the simple treatment group of Herba Schizonepetae Forsythiae Decoction), C group (normal saline treatment matched group).
2, rat acute radiation-induced skin ulcer modeling
Two back legs, biped and the afterbody of the electron beam irradiation rat of the 4Me V produced with linear accelerator, non-irradiated site shields with stereotype, exposure rate is 200cGy/min, laboratory animal once irradiating dosage is 45Gy, about 14 days, two back legs, biped and afterbody form ulcer, as the acute radiation-induced skin ulcers model.
3, GP TH scheme
A group: start in the 2nd day after irradiation with 5% Herba Schizonepetae Forsythiae Decoction solution soak, every day 2 times, finish until observe;
B group: start in the 15th day after irradiation with 5% Herba Schizonepetae Forsythiae Decoction solution soak, every day 2 times, finish until observe;
C group: start to use the normal saline soak in latter 15 days in irradiation, every day 2 times, finish until observe.
4, soak method
6 layers of yarn piece are dipped in corresponding solution, are screwed onto and do not drip for degree, spread on rats with bilateral buttocks, two back leg and afterbody, and adhesive tape is fixed, and each 30 minutes, every day 2 times, space-number minute during each soak, addend drips corresponding medicinal liquid to keep suitable humidity.
5, therapeutic evaluation
(1) measurement of rat shank swelling
Adopt volumetric method within the 0th, 14,17,20,23 days, to measure the volume of the left and right shank of rat after irradiation, by the swollen degree of the homemade foot of inventor measuring instrument (referring to Fig. 1), calculate swelling.
As shown in Figure 1, with tee T D by 20ml glass syringe A, 5ml glass pipet B is connected with 5ml disposable syringe C from making the swollen degree of foot measuring device, be adjusted to glass syringe and glass pipet UNICOM at tee T, add tap water in glass syringe, close tee T when in glass pipet, horizontal plane rises to the c point, continue to add water in glass syringe, in glass pipet, horizontal plane rises to a point, by rat shank knee joint band place labelling one horizontal line, extend in glass syringe, until the horizontal line position arrives the b line, Communicating device is adjusted to glass syringe and disposable syringe connection, extract the water in glass syringe, until the horizontal plane of glass pipet is got back to a line, Communicating device is adjusted to disposable syringe and glass pipet connection, by the water in disposable syringe, all push in glass pipet, the glass pipet middle water level is raised to the d point from the c point, c, between d, the volume of water is designated as the volume of Mus shank.
Shank volume before shank swelling=one-tenth mould gaskin volume-film forming.
(2) observation index of wound surface, observational technique and evaluation criterion
2.1 the observation index of wound surface
Erythema: without erythema, remember 0 minute; Visible and the diameter of erythema is less than 1cm note 1 minute; Erythema is obvious, and diameter is greater than 1cm, but is no more than the shank gross area 50% note 2 minutes; Erythema is remarkable, and area surpasses the shank gross area 50% note 3 minutes.
Vesicle: remember 0 minute without vesicle, the vesicle diameter is less than 0.5cm note 1 minute, and the vesicle diameter is less than 1cm note 2 minutes, and the vesicle diameter is greater than 1cm note 3 minutes.
Rotten to the corn: remember 0 minute without rotten to the corn, rotten to the corn face diameter is less than 0.5cm note 1 minute, and rotten to the corn face diameter is less than 1cm note 2 minutes, and rotten to the corn face diameter is greater than 1cm note 3 minutes.
Sepage: remember 0 minute without sepage, a small amount of sepage note 1 minute, obviously the sepage note is 2 minutes, and the sepages note is 3 minutes in a large number.
Ulcer: remember 0 minute without ulcer, the ulcer surface diameter is less than 0.5cm note 1 minute, and the ulcer surface diameter is less than 1cm note 2 minutes, and the ulcer surface diameter is greater than 1cm note 3 minutes.
Suppurate: remember 0 minute without pus, a small amount of pus note 1 minute, obviously the pus note is 2 minutes, and the puss note is 3 minutes in a large number.
2.2 observational technique
Respectively at the 14th, 17,20,23 days observed and recorded skin lesion situations of change after irradiating, if actual healing time is recorded in healing.
2.3 statistical method
With the SPSS13.0 statistical software, experimental data is carried out to statistical analysis, measurement data means with ± S, and each index is all analyzed with the variance analysis of repeated measurement data, and each time point relatively adopts one factor analysis of variance (One-way Annova), multiple comparisons adopts the SNK method, gets P=0.05.
(3) result
3.1 the impact on rat shank swelling
Modeling first three groups rat hindlimb volume Analysis of variance difference not statistically significant (P=0.819), A, B, the tri-groups of swollen degree of foot test results of C are respectively: 16.33 ± 2.39; 15.83 ± 1.58; 15.92 ± 2.15.The swollen degree of different time points foot shows discontented football check (P=0.006) through the variance analysis of repeated measure, select the Greenhouse-Geisser assay to show that between different time points, difference has significant difference (P=0.000), non-interaction action (P=0.488) between time and grouping factor, point out three prescription methods identical to the alleviation trend of Mus shank swelling.Between object, the measure of merit result shows, between the grouping factor, difference has statistical significance (F=4.993, P=0.013), through SNK, compare in twos, when the 14th day and the 23rd day, A group and B, the swollen degree of C group foot difference difference have statistical significance, and in the time of the 17th day, the A group has statistical significance with the swollen degree of C group foot difference difference.Result shows, Herba Schizonepetae Forsythiae Decoction prophylactic treatment group can obviously suppress the inflammatory reaction of rat shank, and the swelling of each time point rat shank all is lighter than other 2 groups.Referring to Fig. 2 and table 1.
Table 1: different time points not on the same group rat shank swelling measure
* SNK compares in twos, the p=0.05 level, and same time foot swollen degree difference A and B, C group comparing difference have statistical significance.
#SNK compares in twos, the p=0.05 level, and same time foot swollen degree difference A and C group comparing difference have statistical significance.
3.2 rat shank erythema situation relatively
The different time points scores of erythema shows discontented football check (P=0.011) through the variance analysis of repeated measure, select the Greenhouse-Geisser assay to show that between different time points, difference has significant difference (P=0.000), non-interaction action (P=0.430) between time and grouping factor, point out three prescription methods identical to the inhibition trend of erythema.Between object, the measure of merit result shows, between the grouping factor, difference has statistical significance (F=17.688, P<0.001), and variance analysis shows all has statistical significance (F=3.667, P=0.036 between each group of scores of erythema in the 14th, 17,20 and 23 days; F=5.923, P=0.006; F=7.800, P=0.002; F=11.733, P=0.000), the 14th day, through the SNK multiple comparisons, difference not statistically significant between the 14th day three groups of scores of erythemas, the 17th day B group and A, C group difference have statistical significance, and the 20th, 23 days A groups and B, C group erythema difference have statistical significance.Result shows, Herba Schizonepetae Forsythiae Decoction prophylactic treatment group rat shank erythema significantly is lighter than other two groups (referring to Fig. 3).
3.3 a situation arises for vesicle.
Each group is not all observed the generation of obvious vesicle.
3.4 the rotten to the corn situation of rat shank
The rotten to the corn scoring of different time points shows discontented football check (P<0.001) through the variance analysis of repeated measure, select the Greenhouse-Geisser check to show that between different time points, difference has significant difference (P=0.000), reciprocal action (P=0.000) is arranged between time and grouping factor, between object, the measure of merit result shows, between the grouping factor, difference has statistical significance (F=13.647, P<0.001), variance analysis shows the 14th, 17,20 and 23 days all has statistical significance (F=10.081, P=0.000 between rotten to the corn each group of scoring; , F=13.331, P=0.000; F=8.412, P=0.001; F=5.987, P=0.006), each time point compares in twos through SNK, and A group and B, C organize rotten to the corn diversity of values all statistical significance, and the erosion of B, C group improves the identical intersection to some extent of trend as can be seen from Figure 4, and A organizes rotten to the corn degree and is lighter than the BC group.
3.5 rat shank sepage situation
Different time points sepage scoring meets sphericity test (P=0.083) through the variance analysis of repeated measure, result shows that between different time points, difference has significant difference (P=0.000), reciprocal action (P=0.004) is arranged between time and grouping factor, between object, the measure of merit result shows, between the grouping factor, difference has statistical significance (F=19.479, P<0.001), variance analysis demonstration sepage in the 14th, 17,20 and 23 days is marked between each group statistical significance (F=21.595, P=0.000 is all arranged; , F=23.618, P=0.000; F=7.526, P=0.002; F=6.600, P=0.004), through SNK, compare in twos, the 14th, 17,20 days A groups and B, C group sepage diversity of values have statistical significance, and the 23rd day, B group and A, C organized difference that statistical significance is arranged.A group sepage degree is lighter than B, C group (referring to Fig. 5).
3.6 rat ulcus cruris situation
The scoring of different time points ulcer shows discontented football check (P=0.012) through the variance analysis of repeated measure, select the Greenhouse-Geisser assay to show that between different time points, difference has significant difference (P<0.001), reciprocal action (P<0.001) is arranged between time and grouping factor, between object, the measure of merit result shows, between the grouping factor, difference has statistical significance (F=19.803, P<0.001), the 14th, 17,20 and 23 days ulcer of variance analysis demonstration is marked between each group statistical significance (F=18.296, P=0.000 is all arranged; , F=29.806, P=0.000; F=11.874, P=0.000; F=5.987, P=0.006), through SNK, compare in twos, within the 14th day, three group differences all have statistical significance, and the 17th, 20,23 days A groups and B, C group ulcer diversity of values have statistical significance.Results suggest A group ulcer is lighter than B, C group, the generation (referring to Fig. 6) that the preventative soak of prompting JJLQT can alleviate radiodermatitis ulcer.
3.7 rat shank suppuration situation
4 time points of A group are not all observed shank and are suppurated, and the C group starts all rats without suppuration on the 20th day, the B group in the time of the 23rd day all rats without pus, (referring to Fig. 7).
3.8 all perusal index scoring Macro or mass analysis
Different time points observation index total points shows discontented football check (P=0.000) through the variance analysis of repeated measure, select the Greenhouse-Geisser assay to show that between different time points, difference has significant difference (P<0.001), reciprocal action (P<0.001) is arranged between time and grouping factor, between object, the measure of merit result shows, between the grouping factor, difference has statistical significance (F=18.052, P<0.001), variance analysis shows all has statistical significance (F=19.574, P=0.000 between each group of overall score in the 14th, 17,20 and 23 days; , F=23.034, P=0.000; F=12.266, P=0.000; F=6.309, P=0.002), through SNK, compare in twos, within the 14th day, three group differences all have statistical significance, and the 17th, 20,23 days A groups and B, C group overall score difference have statistical significance.Results suggest A group integration totally significantly is lighter than B, C group, the inflammatory reaction (referring to Fig. 8) that the preventative soak of prompting JJLQT can alleviate radiodermatitis.
In sum, every cutaneous manifestations of Herba Schizonepetae Forsythiae Decoction prophylactic treatment group generation radiodermatitis all significantly is lighter than simple treatment group and normal saline matched group, and the change of three kinds of method group scytitiss all is with the prolongation of poor time the trend alleviated.The present invention points out the treatment of Herba Schizonepetae Forsythiae Decoction early prevention can alleviate the degree of radiodermatitis.
This modeling is to set the dosage of ray according to the model that causes radiation-induced skin ulcer, therefore unavoidably radiodermatitis will occur, thereby confirms the effect of Herba Schizonepetae Forsythiae Decoction for treating radiation dermatitis.Clinically, the ray energy of single therapy dosage is smaller, generally need after repeatedly irradiating, just have the part patient that radiodermatitis occurs.Therefore, from this result of study, if medication even in advance immediately prevents the radiodermatitis reaction that can reduce inflammation after irradiating each time, reach the purpose of prevention.Therefore, clinical radiotherapy patient is conventional uses the soak of Herba Schizonepetae Forsythiae Decoction, can effectively prevent or treating radiation dermatitis as early as possible.
Claims (4)
1. the Herba Schizonepetae Forsythiae Decoction is for the preparation of the purposes of the medicine of prevention and treatment acute radiodermatitis.
2. purposes according to claim 1, it is characterized in that, the raw material of Chinese medicine of described Herba Schizonepetae Forsythiae Decoction is comprised of following Chinese medicine: Herba Schizonepetae 10 grams, Fructus Forsythiae 20 grams, the Radix Angelicae Dahuricae 10 grams, the Radix Rehmanniae 15 grams, the Radix Paeoniae Alba 10 grams, Radix Angelicae Sinensis 20 grams, Rhizoma Chuanxiong 15 grams, Radix Glycyrrhizae 10 grams, Radix Bupleuri 24 grams, Radix Platycodonis 10 grams, Radix Saposhnikoviae 20 grams, Fructus Aurantii 10 grams, Herba Menthae 10 grams, Rhizoma Coptidis 15 grams, Cortex Phellodendri 20 grams, Fructus Gardeniae 15 grams, Radix Scutellariae 20 grams, symbiosis medicine 254 grams.
3. purposes according to claim 1, is characterized in that, that described Herba Schizonepetae Forsythiae Decoction is prepared as is for oral administration, the preparation of washout or external application.
4. purposes according to claim 3, is characterized in that, described Herba Schizonepetae Forsythiae Decoction is prepared as Wet-dressing agent, and its preparation method is: by crude drug totally 3 pairs respectively water boiling concentration become 5080ml, obtain 5% solution; Then 115 ℃, 15 minutes autoclavings, 4 ℃ of Refrigerator stores are standby; Each used time shakes up pours out in right amount, and water-bath is heated and used after 25 ℃.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104491113A (en) * | 2014-12-25 | 2015-04-08 | 夏吉凯 | Traditional Chinese medicine for treating radiodermatitis |
| CN104491545A (en) * | 2014-12-25 | 2015-04-08 | 王旭 | Traditional Chinese medicine for treating occupational diseases of radiology department |
| CN104623313A (en) * | 2015-02-02 | 2015-05-20 | 青岛大学附属医院 | Traditional Chinese medicine composition for preventing and treating radiodermatitis |
-
2013
- 2013-09-11 CN CN2013104131869A patent/CN103446329A/en active Pending
Non-Patent Citations (1)
| Title |
|---|
| 兰梅梅等: "《荆芥连翘汤预防性湿敷对大鼠放射性皮炎的影响》", 《中国皮肤性病学杂志》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104491113A (en) * | 2014-12-25 | 2015-04-08 | 夏吉凯 | Traditional Chinese medicine for treating radiodermatitis |
| CN104491545A (en) * | 2014-12-25 | 2015-04-08 | 王旭 | Traditional Chinese medicine for treating occupational diseases of radiology department |
| CN104623313A (en) * | 2015-02-02 | 2015-05-20 | 青岛大学附属医院 | Traditional Chinese medicine composition for preventing and treating radiodermatitis |
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Application publication date: 20131218 |