CN103445973A - Nano fiber whitening and freckle-removing mask paste - Google Patents
Nano fiber whitening and freckle-removing mask paste Download PDFInfo
- Publication number
- CN103445973A CN103445973A CN2013104037049A CN201310403704A CN103445973A CN 103445973 A CN103445973 A CN 103445973A CN 2013104037049 A CN2013104037049 A CN 2013104037049A CN 201310403704 A CN201310403704 A CN 201310403704A CN 103445973 A CN103445973 A CN 103445973A
- Authority
- CN
- China
- Prior art keywords
- solution
- whitening
- pastes
- spinning
- gsh
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000002087 whitening effect Effects 0.000 title claims abstract description 33
- 239000002121 nanofiber Substances 0.000 title abstract description 14
- 208000003351 Melanosis Diseases 0.000 title abstract 5
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 claims abstract description 78
- 229960003180 glutathione Drugs 0.000 claims abstract description 44
- 238000009987 spinning Methods 0.000 claims abstract description 25
- 230000003064 anti-oxidating effect Effects 0.000 claims abstract description 16
- 229920000742 Cotton Polymers 0.000 claims abstract description 9
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 21
- 230000001815 facial effect Effects 0.000 claims description 19
- 235000003969 glutathione Nutrition 0.000 claims description 16
- 239000002671 adjuvant Substances 0.000 claims description 13
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 11
- 238000002156 mixing Methods 0.000 claims description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
- 230000010355 oscillation Effects 0.000 claims description 9
- 238000002360 preparation method Methods 0.000 claims description 9
- 238000013019 agitation Methods 0.000 claims description 7
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 6
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 6
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims description 6
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 6
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims description 6
- 239000008367 deionised water Substances 0.000 claims description 6
- 229910021641 deionized water Inorganic materials 0.000 claims description 6
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 6
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 6
- 229920001661 Chitosan Polymers 0.000 claims description 5
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 5
- 239000001168 astaxanthin Substances 0.000 claims description 5
- 229940022405 astaxanthin Drugs 0.000 claims description 5
- 229950001002 cianidanol Drugs 0.000 claims description 5
- 239000011718 vitamin C Substances 0.000 claims description 5
- 229920003169 water-soluble polymer Polymers 0.000 claims description 5
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims description 4
- DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 claims description 4
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 claims description 4
- 239000002904 solvent Substances 0.000 claims description 4
- PFTAWBLQPZVEMU-DZGCQCFKSA-N (+)-catechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-DZGCQCFKSA-N 0.000 claims description 3
- JEBFVOLFMLUKLF-IFPLVEIFSA-N Astaxanthin Natural products CC(=C/C=C/C(=C/C=C/C1=C(C)C(=O)C(O)CC1(C)C)/C)C=CC=C(/C)C=CC=C(/C)C=CC2=C(C)C(=O)C(O)CC2(C)C JEBFVOLFMLUKLF-IFPLVEIFSA-N 0.000 claims description 3
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims description 3
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 3
- 229930003268 Vitamin C Natural products 0.000 claims description 3
- 235000013793 astaxanthin Nutrition 0.000 claims description 3
- MQZIGYBFDRPAKN-ZWAPEEGVSA-N astaxanthin Chemical compound C([C@H](O)C(=O)C=1C)C(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)C(=O)[C@@H](O)CC1(C)C MQZIGYBFDRPAKN-ZWAPEEGVSA-N 0.000 claims description 3
- 235000005487 catechin Nutrition 0.000 claims description 3
- ADRVNXBAWSRFAJ-UHFFFAOYSA-N catechin Natural products OC1Cc2cc(O)cc(O)c2OC1c3ccc(O)c(O)c3 ADRVNXBAWSRFAJ-UHFFFAOYSA-N 0.000 claims description 3
- -1 polyoxyethylene Polymers 0.000 claims description 3
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 3
- 235000019154 vitamin C Nutrition 0.000 claims description 3
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 2
- BYEAHWXPCBROCE-UHFFFAOYSA-N 1,1,1,3,3,3-hexafluoropropan-2-ol Chemical compound FC(F)(F)C(O)C(F)(F)F BYEAHWXPCBROCE-UHFFFAOYSA-N 0.000 claims description 2
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 claims description 2
- 239000004255 Butylated hydroxyanisole Substances 0.000 claims description 2
- ACTIUHUUMQJHFO-UHFFFAOYSA-N Coenzym Q10 Natural products COC1=C(OC)C(=O)C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UHFFFAOYSA-N 0.000 claims description 2
- 108010010803 Gelatin Proteins 0.000 claims description 2
- 229920002472 Starch Polymers 0.000 claims description 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims description 2
- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 claims description 2
- 241000209140 Triticum Species 0.000 claims description 2
- 235000021307 Triticum Nutrition 0.000 claims description 2
- OENHQHLEOONYIE-UKMVMLAPSA-N all-trans beta-carotene Natural products CC=1CCCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C OENHQHLEOONYIE-UKMVMLAPSA-N 0.000 claims description 2
- 235000013734 beta-carotene Nutrition 0.000 claims description 2
- TUPZEYHYWIEDIH-WAIFQNFQSA-N beta-carotene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2=CCCCC2(C)C TUPZEYHYWIEDIH-WAIFQNFQSA-N 0.000 claims description 2
- 239000011648 beta-carotene Substances 0.000 claims description 2
- 229960002747 betacarotene Drugs 0.000 claims description 2
- 235000019282 butylated hydroxyanisole Nutrition 0.000 claims description 2
- CZBZUDVBLSSABA-UHFFFAOYSA-N butylated hydroxyanisole Chemical compound COC1=CC=C(O)C(C(C)(C)C)=C1.COC1=CC=C(O)C=C1C(C)(C)C CZBZUDVBLSSABA-UHFFFAOYSA-N 0.000 claims description 2
- 229940043253 butylated hydroxyanisole Drugs 0.000 claims description 2
- 238000005352 clarification Methods 0.000 claims description 2
- 235000017471 coenzyme Q10 Nutrition 0.000 claims description 2
- ACTIUHUUMQJHFO-UPTCCGCDSA-N coenzyme Q10 Chemical compound COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UPTCCGCDSA-N 0.000 claims description 2
- 229940110767 coenzyme Q10 Drugs 0.000 claims description 2
- YTJJRAWFHJBAMT-UHFFFAOYSA-N depside Natural products OC(=O)CC1=C(O)C=C(O)C=C1OC(=O)C1=CC=C(O)C(O)=C1 YTJJRAWFHJBAMT-UHFFFAOYSA-N 0.000 claims description 2
- 229930003944 flavone Natural products 0.000 claims description 2
- 150000002212 flavone derivatives Chemical class 0.000 claims description 2
- 235000011949 flavones Nutrition 0.000 claims description 2
- HVQAJTFOCKOKIN-UHFFFAOYSA-N flavonol Natural products O1C2=CC=CC=C2C(=O)C(O)=C1C1=CC=CC=C1 HVQAJTFOCKOKIN-UHFFFAOYSA-N 0.000 claims description 2
- 150000002216 flavonol derivatives Chemical class 0.000 claims description 2
- 235000011957 flavonols Nutrition 0.000 claims description 2
- 235000019253 formic acid Nutrition 0.000 claims description 2
- 229920000159 gelatin Polymers 0.000 claims description 2
- 239000008273 gelatin Substances 0.000 claims description 2
- 235000019322 gelatine Nutrition 0.000 claims description 2
- 235000011852 gelatine desserts Nutrition 0.000 claims description 2
- 229920002674 hyaluronan Polymers 0.000 claims description 2
- 229960003160 hyaluronic acid Drugs 0.000 claims description 2
- 150000007965 phenolic acids Chemical class 0.000 claims description 2
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 2
- 235000018102 proteins Nutrition 0.000 claims description 2
- 102000004169 proteins and genes Human genes 0.000 claims description 2
- 108090000623 proteins and genes Proteins 0.000 claims description 2
- 235000019698 starch Nutrition 0.000 claims description 2
- 239000008107 starch Substances 0.000 claims description 2
- 239000000126 substance Substances 0.000 claims description 2
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 claims description 2
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 claims description 2
- 238000010041 electrostatic spinning Methods 0.000 abstract description 12
- 239000002105 nanoparticle Substances 0.000 abstract description 12
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 abstract description 10
- 108010024636 Glutathione Proteins 0.000 abstract description 6
- 238000000034 method Methods 0.000 abstract description 6
- 230000005855 radiation Effects 0.000 abstract description 4
- 102000003425 Tyrosinase Human genes 0.000 abstract description 3
- 108060008724 Tyrosinase Proteins 0.000 abstract description 3
- 230000004071 biological effect Effects 0.000 abstract description 3
- 230000000694 effects Effects 0.000 abstract description 3
- 239000000463 material Substances 0.000 abstract 4
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000004744 fabric Substances 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- PXQLVRUNWNTZOS-UHFFFAOYSA-N sulfanyl Chemical compound [SH] PXQLVRUNWNTZOS-UHFFFAOYSA-N 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 26
- 238000005538 encapsulation Methods 0.000 description 9
- 239000000835 fiber Substances 0.000 description 8
- 239000011259 mixed solution Substances 0.000 description 6
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 5
- 230000002779 inactivation Effects 0.000 description 5
- 238000001523 electrospinning Methods 0.000 description 4
- 239000004615 ingredient Substances 0.000 description 4
- 239000007921 spray Substances 0.000 description 4
- 206010025421 Macule Diseases 0.000 description 3
- 230000001476 alcoholic effect Effects 0.000 description 3
- 239000007864 aqueous solution Substances 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 238000004299 exfoliation Methods 0.000 description 3
- 239000012528 membrane Substances 0.000 description 3
- 230000003020 moisturizing effect Effects 0.000 description 3
- 150000003254 radicals Chemical class 0.000 description 3
- 239000003643 water by type Substances 0.000 description 3
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- 238000013459 approach Methods 0.000 description 2
- 229960000935 dehydrated alcohol Drugs 0.000 description 2
- 229960004756 ethanol Drugs 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 238000007789 sealing Methods 0.000 description 2
- 230000008685 targeting Effects 0.000 description 2
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- CITFYDYEWQIEPX-UHFFFAOYSA-N Flavanol Natural products O1C2=CC(OCC=C(C)C)=CC(O)=C2C(=O)C(O)C1C1=CC=C(O)C=C1 CITFYDYEWQIEPX-UHFFFAOYSA-N 0.000 description 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 1
- 108010053070 Glutathione Disulfide Proteins 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 description 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 1
- 108010038807 Oligopeptides Proteins 0.000 description 1
- 102000015636 Oligopeptides Human genes 0.000 description 1
- 229920003081 Povidone K 30 Polymers 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 230000003796 beauty Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 1
- 235000018417 cysteine Nutrition 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 description 1
- 235000011987 flavanols Nutrition 0.000 description 1
- 235000013922 glutamic acid Nutrition 0.000 description 1
- 239000004220 glutamic acid Substances 0.000 description 1
- YPZRWBKMTBYPTK-BJDJZHNGSA-N glutathione disulfide Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@H](C(=O)NCC(O)=O)CSSC[C@@H](C(=O)NCC(O)=O)NC(=O)CC[C@H](N)C(O)=O YPZRWBKMTBYPTK-BJDJZHNGSA-N 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 239000012456 homogeneous solution Substances 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000001243 protein synthesis Methods 0.000 description 1
- 239000002516 radical scavenger Substances 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000037394 skin elasticity Effects 0.000 description 1
- 230000014616 translation Effects 0.000 description 1
Landscapes
- Cosmetics (AREA)
Abstract
The invention discloses a nano fiber whitening and freckle-removing mask paste. The nano fiber whitening and freckle-removing mask paste comprises a spinning solution and cotton cloth, wherein active components of the spinning solution are reduced glutathione and an anti-oxidizing auxiliary material; the mass ratio of the reduced glutathione to the anti-oxidizing auxiliary material is equal to 1-10. According to the nano fiber whitening and freckle-removing mask paste, whitening and freckle-removing effective components are the reduced glutathione (GSH) and the anti-oxidizing auxiliary material, wherein the GSH is dispersed into a nano fiber in a nano particle manner; the anti-oxidizing auxiliary material can keep a reduced state of an active radical sulfhydryl (-SH) in the GSH and the biological activity is kept. The reduced glutathione inhibits the activity of tyrosinase, eliminates active oxygen or free radicals, treats radiation diseases and carries out radiation protection, so as to inhibit the formation of melanin; the reduced glutathione is combined with an electrostatic spinning technique to realize advantage complementation.
Description
Technical field
The present invention relates to electrostatic spinning and beauty and skin care field, more specifically, relate to a kind of electrostatic spinning nano fiber facial masks for whitening faces and removing spots and paste.
Background technology
Electrostatic spinning is a kind ofly by electrostatic force, polymer solution or melt to be stretched and produce taylor cone, and sprays the process technology that is stretched as superfine fibre.The superfine fibre specific surface area that this technology is produced is larger, and draw ratio is high, and some natural and synthetic macromolecule has been widely used in the nanotechnology association areas such as organizational project; Glutathion is a kind of oligopeptide that is present in all living cells, has important physiological function, glutamic acid, cysteine, glycine, consists of, and is divided into reduced glutathion (GSH) and oxidized form of glutathione (GSSG).In vivo, reduced glutathion (GSH) is main activated state, accounts for 95%.The approach of skin-whitening and speckle eliminating mainly contains two kinds: the one, and the generation of check melanin; The 2nd, impel the melanin generated to excrete (J Environ Health 2010,27 (8): 745-748).And GSH is a kind of potent antioxidant, can remove that free radical, restraint of tyrosinase are active, blocking-up melanin is synthetic, thus effective dispelling stain; Also can promote collagen protein synthesis, improve skin elasticity.
At present electrostatic spinning technique and targeting loading is combined with certain progress, yet due to reduced glutathion (GSH) inactivation very easily, therefore the research that electrospinning fibre carries GSH about bag rarely has report, and existing glutathion product is main mainly with oral and injection, at first, through body-internal-circulation, the sulfydryl of GSH (SH) is approach exhaustion with the interior abundant combined with radical of body; Secondly, because GSH concentration is diluted by body fluid, the glutathion that can arrive mottle or wound target area is few, so the whitening repair is difficult to reach expection.How to improve the GSH utilization rate, reduce the GSH inactivation rate and become a difficult problem urgently to be resolved hurrily at present.
Summary of the invention
The objective of the invention is to overcome the technological deficiency of above-mentioned existing glutathion whitening product, provide a kind of facial masks for whitening faces and removing spots to paste, the nanofiber bag of described mask sheet based on electrostatic spinning technique carries GSH and antioxidation adjuvant mixing nano-particle, thereby reaches the effect of efficiently preserve activity composition GSH targeting release.
Above-mentioned purpose of the present invention is achieved by following technical solution:
A kind of facial masks for whitening faces and removing spots pastes, comprise spinning solution and cotton, the active component of described spinning solution is reduced glutathion (GSH) and antioxidation adjuvant, its mass ratio is reduced glutathion: antioxidation adjuvant=1 ~ 10, under this ratio, not only guarantee the whitening effect component content, and make it keep biological activity.
In above-mentioned facial masks for whitening faces and removing spots pastes, described antioxidation adjuvant is one or more the mixing in vitamin C, Butylated hydroxyanisole, natural astaxanthin, coenzyme Q10, beta-carotene, catechin (flavanol compound), flavone, flavonols, anthocyan, phenolic acid and depside polyphenolic substance.
In above-mentioned facial masks for whitening faces and removing spots pastes, the preparation method of described spinning solution comprises the steps:
(1), by water soluble polymer and solvent, the higher-order of oscillation or magnetic agitation are to evenly making solution A;
(2) reduced glutathion and antioxidation adjuvant are dissolved in deionized water and rapidly the higher-order of oscillation to clarification make solution B;
(3) above-mentioned steps gained solution A is mixed with solution B and rapidly the higher-order of oscillation or magnetic agitation even, form spinning solution.
In above-mentioned facial masks for whitening faces and removing spots pastes, described water soluble polymer is preferably one or more the mixing in polyvinyl alcohol, polyvinylpyrrolidone, water-soluble chitosan, polyoxyethylene, wheat protein, starch, gelatin, hyaluronic acid.
In above-mentioned facial masks for whitening faces and removing spots pastes, the described solvent of step (1) is preferably one or more the mixing in formic acid, acetic acid, acetone, methanol, ethanol, dichloromethane, chloroform, dimethyl formamide, oxolane, trifluoroacetic acid, hexafluoro-2-propanol.
In above-mentioned facial masks for whitening faces and removing spots pastes, the mass concentration of described solution B is 15% ~ 25%, can control the nano-particle diameter between 20 ~ 100nm, guarantees the high capacity rate of effective ingredient, low inactivation rate.The mass concentration of solution A is 3% ~ 100%, and the volume ratio of solution A and solution B is A:B=20 ~ 30:1, with the ratio of water in regulator solution, GSH is separated out and form homodisperse suspended nano granule.
In above-mentioned facial masks for whitening faces and removing spots pastes, the spinning speed range of the described spinning solution of step (3) is 0.5 ~ 1.5mL/h, the spinning voltage scope is between 12 ~ 30kV, to regulate to control its diameter between 200nm ~ 800nm, and effectively bag carries GSH-antioxidation adjuvant mixing nano-particle., spinning ambient humidity≤60%, ambient temperature range is 4 ℃ ~ 30 ℃, and humidity is excessive, the too low effectively filamentation of temperature, and excess Temperature easily makes the effective ingredient inactivation.
Compared with prior art, the present invention has following beneficial effect:
Facial masks for whitening faces and removing spots of the present invention pastes, be mainly the electrostatic spinning nano fiber, the spinning solution main component for preparing fiber is water-soluble polymer solution, the whitening and speckle dispelling effective ingredient is reduced glutathion (GSH) and antioxidation adjuvant, wherein GSH is scattered in nanofiber with the form of nano-particle, the antioxidation adjuvant can maintain active group sulfydryl (SH) in GSH in reducing condition, keeps its biological activity.But the vigor of reduced glutathion restraint of tyrosinase, Scavenger of ROS or free radical, treatment Radiation sickness and radiation protection, thereby check melanin forms, and it is combined with electrostatic spinning technique, realizes having complementary advantages.
Mask sheet of the present invention is based on this relatively ripe nanotechnology of electrostatic spinning, and designed preparation flow is simply ingenious, the processing technique safety non-toxic.Can realize that the fibre diameter of controlling mask sheet is below micron order, make itself and target skin seamless applying, drug effect is given full play to.
Described nanofiber facial masks for whitening faces and removing spots paste broken through traditional GSH whitening and speckle dispelling product can only be with injection or oral this poor efficiency and loaded down with trivial details form is processed as nano-particle by GSH is combined with the antioxidation adjuvant, greatly reduce the inactivation rate of GSH; The nanometer bag of having realized whitening and speckle dispelling skin protection effective ingredient carries, and its utilization rate is maximized.
The specific embodiment
Further explain the present invention below in conjunction with specific embodiment, but embodiment does not do any type of restriction to the present invention.
embodiment 1:
1. the preparation of spinning solution:
A) take 1000 milligrams of PVP-K30(mean molecule quantity=40000), be dissolved in the 2mL dehydrated alcohol, by sealed membrane sealing, magnetic agitation 1 hour, make 50% (wt.%, lower same) PVP alcoholic solution, stand-by.
B) take respectively GSH and the vitamin C of 10 milligrams, mixing is dissolved in the rapid higher-order of oscillation in 100 μ L deionized waters and within 5 minutes, obtains settled solution, immediately it added to the described PVP alcoholic solution of step a and continue to be stirred to evenly, obtaining the final mixed solution that contains finely dispersed GSH-vitamin C nano-particle.
2. mask sheet preparation process:
Step 1 gained mixed solution is carried out to electrostatic spinning, set spinning speed 0.7mL/h, voltage 15kV, and receive electrospinning fibre with ultra-thin cotton, just become approximately a 15 * 15cm after 1 hour
2the nanofiber face mask for eliminating macula and whitening skin paste.
3. the encapsulation of mask sheet: step 2, after the dry 1h of prepared mask sheet normal-temperature vacuum, is divided into to 5 * 5cm
2size, and with the encapsulation of lucifuge bag, kept dry.
4. the use of mask sheet: target skin is carried out to exfoliation and cleans, keep target skin wetness state, after being taken apart, the mask sheet of encapsulation sticks affected part, spray a small amount of deionized water, GSH-vitamin C nano-particle can be released, keep after 10-20 minute, GSH sees through horny layer equably, and ultra-thin cotton can carry out moisturizing and clean to skin simultaneously.
embodiment 2:
1. the preparation of spinning solution:
C) take 300 milligrams of PVA(mean molecule quantity=75000), be dissolved in the 1mL deionized water, with the sealed membrane sealing, 80 ℃ of magnetic agitation add the vibration of 1mL dehydrated alcohol evenly to make 15%PVP ethanol water (ethanol/water, 1/1) after 3 hours, stand-by.
D) take respectively GSH and the catechin of 10 milligrams, mixing is dissolved in the rapid higher-order of oscillation in 100 μ L deionized waters and within 5 minutes, obtains settled solution, immediately it added to the described PVP alcoholic solution of step a and continue to be stirred to evenly, obtaining the final mixed solution that contains finely dispersed GSH-catechin nano-particle.
2. mask sheet preparation process:
Step 1 gained mixed solution is carried out to electrostatic spinning, set spinning speed 0.7mL/h, voltage 15kV, and receive electrospinning fibre with ultra-thin cotton, just become approximately a 15 * 15cm after 1 hour
2the nanofiber face mask for eliminating macula and whitening skin paste.
3. the encapsulation of mask sheet: step 2, after the dry 1h of prepared mask sheet normal-temperature vacuum, is divided into to 5 * 5cm
2size, and with the encapsulation of lucifuge bag, kept dry.
4. the use of mask sheet: target skin is carried out to exfoliation and cleans, keep target skin wetness state, after being taken apart, the mask sheet of encapsulation sticks affected part, spray a small amount of deionized water, GSH-catechin nano-particle can be released, keep after 10-20 minute, GSH sees through horny layer equably, and ultra-thin cotton can carry out moisturizing and clean to skin simultaneously.
embodiment 3:
1. the preparation of spinning solution:
E) take respectively 100 milligrams of PEO(mean molecule quantity=100000) and using carboxyl chitosan (mean molecule quantity=30000), miscible in 2mL acetic acid aqueous solution (acetic acid/water, 1/1) in, with sealed membrane, seal, magnetic agitation 1 hour, make the acetic acid aqueous solution (acetic acid/water, 1/1) of 10%PEO/ water-soluble chitosan, stand-by.
F) take respectively GSH and 1 milligram of astaxanthin of 10 milligrams, mixing is dissolved in the rapid higher-order of oscillation in 100 μ L deionized waters and within 5 minutes, obtains homogeneous solution, immediately it added to the acetic acid aqueous solution of the described PEO/ water-soluble chitosan of step a and continue to be stirred to evenly, obtaining the final mixed solution that contains finely dispersed GSH-astaxanthin nano-particle.
2. mask sheet preparation process:
Step 1 gained mixed solution is carried out to electrostatic spinning, set spinning speed 0.7mL/h, voltage 15kV, and receive electrospinning fibre with ultra-thin cotton, just become approximately a 15 * 15cm after 1 hour
2the nanofiber face mask for eliminating macula and whitening skin paste.
3. the encapsulation of mask sheet: step 2, after the dry 1h of prepared mask sheet normal-temperature vacuum, is divided into to 5 * 5cm
2size, and with the encapsulation of lucifuge bag, kept dry.
4. the use of mask sheet: target skin is carried out to exfoliation and cleans, keep target skin wetness state, after being taken apart, the mask sheet of encapsulation sticks affected part, spray a small amount of deionized water, GSH-astaxanthin nano-particle can be released, keep after 10-20 minute, GSH sees through horny layer equably, and ultra-thin cotton can carry out moisturizing and clean to skin simultaneously.
Obviously, the above embodiment of the present invention is only for example of the present invention clearly is described, and is not the restriction to embodiments of the present invention.For those of ordinary skill in the field, can also make other changes in different forms on the basis of the above description.Here exhaustive without also giving all embodiments.All any modifications of doing within the spirit and principles in the present invention, be equal to and replace and improvement etc., within all should being included in the protection domain of the claims in the present invention.
Claims (7)
1. a facial masks for whitening faces and removing spots pastes, and comprises spinning solution and cotton, it is characterized in that, the active component of described spinning solution is reduced glutathion and antioxidation adjuvant, and its mass ratio is reduced glutathion: antioxidation adjuvant=1 ~ 10.
2. facial masks for whitening faces and removing spots according to claim 1 pastes, it is characterized in that, described antioxidation adjuvant is one or more the mixing in vitamin C, Butylated hydroxyanisole, natural astaxanthin, coenzyme Q10, beta-carotene, catechin, flavone, flavonols, anthocyan, phenolic acid and depside polyphenolic substance.
3. facial masks for whitening faces and removing spots according to claim 1 pastes, and it is characterized in that, the preparation method of described spinning solution comprises the steps:
(1), by water soluble polymer and solvent, the higher-order of oscillation or magnetic agitation are to evenly making solution A;
(2) reduced glutathion and antioxidation adjuvant are dissolved in deionized water and rapidly the higher-order of oscillation to clarification make solution B;
(3) above-mentioned steps gained solution A is mixed with solution B and rapidly the higher-order of oscillation or magnetic agitation even, form spinning solution.
4. facial masks for whitening faces and removing spots according to claim 3 pastes, it is characterized in that, described water soluble polymer is one or more the mixing in polyvinyl alcohol, polyvinylpyrrolidone, water-soluble chitosan, polyoxyethylene, wheat protein, starch, gelatin, hyaluronic acid.
5. facial masks for whitening faces and removing spots according to claim 3 pastes, it is characterized in that, the described solvent of step (1) is one or more the mixing in formic acid, acetic acid, acetone, methanol, ethanol, dichloromethane, chloroform, dimethyl formamide, oxolane, trifluoroacetic acid, hexafluoro-2-propanol.
6. facial masks for whitening faces and removing spots according to claim 3 pastes, and it is characterized in that, the mass concentration of described solution B is 15% ~ 25%, and the mass concentration of solution A is 3% ~ 100%, and the volume ratio of solution A and solution B is A:B=20 ~ 30:1.
7. facial masks for whitening faces and removing spots according to claim 3 pastes, it is characterized in that, the spinning speed range of the described spinning solution of step (3) is 0.5 ~ 1.5ml/h, and the spinning voltage scope is 12 ~ 30kV, spinning ambient humidity≤60%, ambient temperature range is 4 ℃ ~ 30 ℃.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2013104037049A CN103445973A (en) | 2013-09-09 | 2013-09-09 | Nano fiber whitening and freckle-removing mask paste |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2013104037049A CN103445973A (en) | 2013-09-09 | 2013-09-09 | Nano fiber whitening and freckle-removing mask paste |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103445973A true CN103445973A (en) | 2013-12-18 |
Family
ID=49729099
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2013104037049A Pending CN103445973A (en) | 2013-09-09 | 2013-09-09 | Nano fiber whitening and freckle-removing mask paste |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103445973A (en) |
Cited By (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103751057A (en) * | 2014-01-08 | 2014-04-30 | 中山大学 | Skin-whitening moisture-preserving wrinkle-resisting mask liquid and preparation method thereof |
| CN103898625A (en) * | 2013-12-30 | 2014-07-02 | 江苏大学 | Preparation method for catechinic acid-CuII/polyvinylpyrrolidone composite fiber |
| CN104207948A (en) * | 2014-08-18 | 2014-12-17 | 贵州捷欣合金技术开发有限公司 | Spinning liquid and method using same to prepare nanofiber film |
| CN105434321A (en) * | 2015-12-22 | 2016-03-30 | 温州任和教育科技有限责任公司 | Whitening freckle-removing mask and preparation method thereof |
| CN105769702A (en) * | 2016-04-19 | 2016-07-20 | 广州市暨生元生物科技有限公司 | Mask containing bromelain and manufacturing method thereof |
| CN106659287A (en) * | 2014-08-28 | 2017-05-10 | 阿莫生命科学有限公司 | Beauty sheet and method for manufacturing same |
| CN107898716A (en) * | 2018-01-19 | 2018-04-13 | 河南工程学院 | A kind of preparation method of nanofiber dry type facial mask |
| CN107920652A (en) * | 2015-08-24 | 2018-04-17 | 阿莫生命科学有限公司 | Beauty mask and preparation method thereof |
| CN109082774A (en) * | 2018-09-05 | 2018-12-25 | 华南理工大学 | A kind of anti-oxidant nano-fiber composite film and preparation method and application containing Folium Nerviliae fordii extract |
| CN109208106A (en) * | 2018-08-29 | 2019-01-15 | 佛山市森昂生物科技有限公司 | A kind of preparation method rich in collagen SuperPro outlet capacity facial mask fabric |
| CN109363967A (en) * | 2018-11-30 | 2019-02-22 | 广东科盈科技有限公司 | A kind of invisible face pack and preparation method thereof |
| CN109825949A (en) * | 2019-03-11 | 2019-05-31 | 东莞华工创为生物科技有限公司 | A kind of preparation and application of all solid state functional nanofiber membrane |
| CN110343144A (en) * | 2019-07-22 | 2019-10-18 | 中国石油大学(华东) | A kind of therapeutic nano enzyme and preparation method thereof assembled by free yl induction |
| CN111494238A (en) * | 2020-05-19 | 2020-08-07 | 贵州扬生医用器材有限公司 | Repairing and moistening mask containing carboxylated chitosan and preparation method thereof |
| CN113950336A (en) * | 2020-02-07 | 2022-01-18 | 花王株式会社 | Composition for external application to skin |
| CN116370375A (en) * | 2023-03-22 | 2023-07-04 | 陕西慧康生物科技有限责任公司 | Anti-aging composition based on high glutathione content and preparation method thereof |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008149248A2 (en) * | 2007-06-08 | 2008-12-11 | Kimberly-Clark Worldwide, Inc. | Methods of applying skin wellness agents to a nonwoven web through electrospinning nanofibers |
| CN101390814A (en) * | 2008-10-29 | 2009-03-25 | 东南大学 | Beauty mask based on electro spinning nano fiber |
| EP1221927B1 (en) * | 1999-10-08 | 2010-07-28 | The University of Akron | Electrospun skin masks and uses thereof |
| CN101914816A (en) * | 2010-09-03 | 2010-12-15 | 东华大学 | Ferulic acid glyceryl oleate polyvinylpyrrolidone nanometer fiber membrane and preparation and application thereof |
| KR20110077792A (en) * | 2009-12-30 | 2011-07-07 | 주식회사 효성 | Method for preparing a cosmetic web and a cosmetic web prepared thereby electrospinning |
| WO2012002389A1 (en) * | 2010-06-29 | 2012-01-05 | 花王株式会社 | Nanofibre |
| CN102560888A (en) * | 2012-01-17 | 2012-07-11 | 东华大学 | Silk fibroin nano-fiber film loaded with water-soluble vitamin E and preparation method for nano-fiber film |
| CN102670415A (en) * | 2012-04-20 | 2012-09-19 | 费兰克·K·高 | Nano fiber paper mask |
-
2013
- 2013-09-09 CN CN2013104037049A patent/CN103445973A/en active Pending
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1221927B1 (en) * | 1999-10-08 | 2010-07-28 | The University of Akron | Electrospun skin masks and uses thereof |
| WO2008149248A2 (en) * | 2007-06-08 | 2008-12-11 | Kimberly-Clark Worldwide, Inc. | Methods of applying skin wellness agents to a nonwoven web through electrospinning nanofibers |
| CN101390814A (en) * | 2008-10-29 | 2009-03-25 | 东南大学 | Beauty mask based on electro spinning nano fiber |
| KR20110077792A (en) * | 2009-12-30 | 2011-07-07 | 주식회사 효성 | Method for preparing a cosmetic web and a cosmetic web prepared thereby electrospinning |
| WO2012002389A1 (en) * | 2010-06-29 | 2012-01-05 | 花王株式会社 | Nanofibre |
| CN101914816A (en) * | 2010-09-03 | 2010-12-15 | 东华大学 | Ferulic acid glyceryl oleate polyvinylpyrrolidone nanometer fiber membrane and preparation and application thereof |
| CN102560888A (en) * | 2012-01-17 | 2012-07-11 | 东华大学 | Silk fibroin nano-fiber film loaded with water-soluble vitamin E and preparation method for nano-fiber film |
| CN102670415A (en) * | 2012-04-20 | 2012-09-19 | 费兰克·K·高 | Nano fiber paper mask |
Non-Patent Citations (2)
| Title |
|---|
| ZHENG-MING HUANG等: "A review on polymer nanofibers by electrospinning and their applications in nanocomposites", 《COMPOSITES SCIENCE AND TECHNOLOGY》 * |
| 王兴雪，等: "静电纺丝纳米纤维的方法与应用现状", 《非织造布》 * |
Cited By (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103898625A (en) * | 2013-12-30 | 2014-07-02 | 江苏大学 | Preparation method for catechinic acid-CuII/polyvinylpyrrolidone composite fiber |
| CN103898625B (en) * | 2013-12-30 | 2016-04-27 | 江苏大学 | A kind of catechin-Cu iIthe preparation method of/polyvinylpyrrolidone composite fibre |
| CN103751057A (en) * | 2014-01-08 | 2014-04-30 | 中山大学 | Skin-whitening moisture-preserving wrinkle-resisting mask liquid and preparation method thereof |
| CN104207948A (en) * | 2014-08-18 | 2014-12-17 | 贵州捷欣合金技术开发有限公司 | Spinning liquid and method using same to prepare nanofiber film |
| CN106659287A (en) * | 2014-08-28 | 2017-05-10 | 阿莫生命科学有限公司 | Beauty sheet and method for manufacturing same |
| CN106659287B (en) * | 2014-08-28 | 2020-11-27 | 阿莫生命科学有限公司 | Beauty treatment sheet and method for producing the same |
| CN107920652A (en) * | 2015-08-24 | 2018-04-17 | 阿莫生命科学有限公司 | Beauty mask and preparation method thereof |
| CN105434321A (en) * | 2015-12-22 | 2016-03-30 | 温州任和教育科技有限责任公司 | Whitening freckle-removing mask and preparation method thereof |
| CN105769702B (en) * | 2016-04-19 | 2019-06-21 | 广州市暨生元生物科技有限公司 | A kind of facial mask and preparation method thereof containing bromelain |
| CN105769702A (en) * | 2016-04-19 | 2016-07-20 | 广州市暨生元生物科技有限公司 | Mask containing bromelain and manufacturing method thereof |
| CN107898716A (en) * | 2018-01-19 | 2018-04-13 | 河南工程学院 | A kind of preparation method of nanofiber dry type facial mask |
| CN107898716B (en) * | 2018-01-19 | 2021-06-29 | 河南工程学院 | Preparation method of nanofiber dry-type facial mask |
| CN109208106A (en) * | 2018-08-29 | 2019-01-15 | 佛山市森昂生物科技有限公司 | A kind of preparation method rich in collagen SuperPro outlet capacity facial mask fabric |
| CN109082774A (en) * | 2018-09-05 | 2018-12-25 | 华南理工大学 | A kind of anti-oxidant nano-fiber composite film and preparation method and application containing Folium Nerviliae fordii extract |
| CN109363967A (en) * | 2018-11-30 | 2019-02-22 | 广东科盈科技有限公司 | A kind of invisible face pack and preparation method thereof |
| CN109825949A (en) * | 2019-03-11 | 2019-05-31 | 东莞华工创为生物科技有限公司 | A kind of preparation and application of all solid state functional nanofiber membrane |
| CN110343144A (en) * | 2019-07-22 | 2019-10-18 | 中国石油大学(华东) | A kind of therapeutic nano enzyme and preparation method thereof assembled by free yl induction |
| CN110343144B (en) * | 2019-07-22 | 2023-02-28 | 中国石油大学(华东) | Therapeutic nano enzyme induced by free radical aggregation and preparation method thereof |
| CN113950336A (en) * | 2020-02-07 | 2022-01-18 | 花王株式会社 | Composition for external application to skin |
| US11642288B2 (en) | 2020-02-07 | 2023-05-09 | Kao Corporation | Skin external composition |
| CN111494238A (en) * | 2020-05-19 | 2020-08-07 | 贵州扬生医用器材有限公司 | Repairing and moistening mask containing carboxylated chitosan and preparation method thereof |
| CN116370375A (en) * | 2023-03-22 | 2023-07-04 | 陕西慧康生物科技有限责任公司 | Anti-aging composition based on high glutathione content and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103445973A (en) | Nano fiber whitening and freckle-removing mask paste | |
| Jan et al. | Biogenic synthesis and characterization of antimicrobial and antiparasitic zinc oxide (ZnO) nanoparticles using aqueous extracts of the Himalayan Columbine (Aquilegia pubiflora) | |
| Sundaram et al. | A study on anti bacterial activity of keratin nanoparticles from chicken feather waste against Staphylococcus aureus (Bovine Mastitis Bacteria) and its anti oxidant activity | |
| Sabarees et al. | Emerging trends in silk fibroin based nanofibers for impaired wound healing | |
| CN105544002B (en) | A kind of high water absorption composite fibre and preparation method thereof | |
| KR20150131285A (en) | Fine dry particulate retinoid active agent compositions and topical formulations including the same | |
| CN113521034A (en) | Composite nano-particles for resisting skin photoaging and preparation method thereof | |
| Coelho et al. | Optimization of electrospinning parameters for the production of zein microstructures for food and biomedical applications | |
| CN110882169A (en) | Dissolving mask for whitening skin and removing freckles and preparation method thereof | |
| Dong et al. | ROS-scavenging materials for skin wound healing: advancements and applications | |
| CN103225175A (en) | Method for preparing polyvinyl alcohol nano fibrous membrane containing nano silver and amino acid | |
| WO2011149112A1 (en) | Solubilized collagen fibers and method for producing the same | |
| Ma et al. | Collagen Scaffolds Functionalized by Cu2+‐Chelated EGCG Nanoparticles with Anti‐Inflammatory, Anti‐Oxidation, Vascularization, and Anti‐Bacterial Activities for Accelerating Wound Healing | |
| Lan et al. | RETRACTED: Xanthan gum/oil body-microgel emulsions with enhanced transdermal absorption for accelerating wound healing | |
| KR102454631B1 (en) | Cosmetic including stem cell-derived ingredient and manufacturing method for the same | |
| Chen et al. | Adaptive Nanoparticle-Mediated Modulation of Mitochondrial Homeostasis and Inflammation to Enhance Infected Bone Defect Healing | |
| Hassan et al. | Advancements in silk fibroin and silk sericin-based biomaterial applications for cancer therapy and wound dressing formulation: A comprehensive review | |
| WO2020072019A2 (en) | Biopolymer based carrier system | |
| KR101512669B1 (en) | Ppg-chitosan hydrogel mask sheet comprising esculin and method for preparing the same | |
| JP6333715B2 (en) | Wound healing promoter | |
| JP2005263655A (en) | Antioxidant | |
| KR101815650B1 (en) | A method for preparing UV screening nanocapsules comprising Poria cocos extract | |
| KR102469249B1 (en) | Functional cosmetic and manufacturing method for the same | |
| CN114009495A (en) | Nano-scale fresh keeping agent for Chinese chestnut and preparation method and fresh keeping method thereof | |
| CN110982633B (en) | Odor-removing bacteriostatic cleaning agent |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C05 | Deemed withdrawal (patent law before 1993) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20131218 |