CN104207948A - Spinning liquid and method using same to prepare nanofiber film - Google Patents
Spinning liquid and method using same to prepare nanofiber film Download PDFInfo
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- CN104207948A CN104207948A CN201410407583.XA CN201410407583A CN104207948A CN 104207948 A CN104207948 A CN 104207948A CN 201410407583 A CN201410407583 A CN 201410407583A CN 104207948 A CN104207948 A CN 104207948A
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Abstract
The invention relates to the technical field of daily chemicals, and concretely relates to a spinning liquid and a method using the same to prepare a nanofiber film. The spinning liquid comprises a film-forming polymer and an active substance. The preparation method for the nanofiber film comprises: preparing the spinning liquid, employing static spinning technology to electrically spin nanometer fiber of the spinning liquid into gauze surface, so as to obtain the nanofiber film. By adjusting variety and addition amount of reagents and the active substance, the whitening, moisture-retention, oxidation-resistant and radiation-resistant effects can be changed. By controlling the diameter of the nanometer fiber and the bulk density of the fiber, the release time and the release quantity of the active substance and the reagents in the fiber film can be controlled.
Description
Technical field
The present invention relates to household chemicals technical field, specifically a kind of spinning liquid and the method for the preparation of nano fibrous membrane thereof.
Background technology
Due to traditional facial film poor air permeability, (in general 20 minutes) face can not be attached to for a long time during use, what cause moisturizing, whitening, antioxidant content not to go deep into is impregnated in skin, skin assimilation effect is poor, produce the effect of curing the symptoms, not the disease, the cosmetic result got is undesirable.
Summary of the invention
The object of the invention is by film forming polymer and active substance blended, utilize electrostatic spinning technique that mixed solution is spun into nano fibrous membrane, make active substance be loaded in electro spinning nano fiber with nanoparticle or blended form by bag inner or be dispersed in its surface.Active substance is present in polymer nanofiber with minimum granule, and the efficiency of stripping or release is higher.Nanofiber is as the carrier of active substance, there is great specific surface area and loose structure, extremely strong interpenetrate power with other materials, pole is beneficial to diffusion and the stripping of medicine, improve the percutaneous transit dose of active substance, improve the method for the electrospun nanofibers film of the percutaneous absorbtion of active substance.
For achieving the above object, the technical solution used in the present invention is: a kind of spinning liquid, and described spinning liquid comprises film forming polymer and active substance, and wherein film forming polymer and active substance ratio of weight and number are 0.1 ~ 100: 0.1 ~ 10.
Further, also comprise medicine and solvent, wherein the parts by weight of film forming polymer, active substance, medicine and solvent are 0.1 ~ 100: 0.1 ~ 10: 0.1 ~ 10: 0.1 ~ 100;
Wherein, medicine is by one or both in erythromycin, Roxithromycin, chlorphenamine maleate, econazole nitrate, dexamethasone acetate, momestasone furoate and form above.
Further, described film forming polymer by polyvinylpyrrolidone, polyvinyl alcohol, soluble cellulose, polyvinyl butyral resin, polyvinyl formal, polyvinyl acetal, in polyvinyl formal-acetal one or both and form above.
Further, described active substance is by one or both in D-lactic acid, amino acid humectant, nicotiamide, vitamin C, vitamin A, vitamin B, watermiscible vitamin E, 1,3 butylene glycol, carbamide, reed fragrant plant glue, beta glucan, hyaluronic acid, trehalose, collagen protein, carbamide and form above.
Further, described solvent is the ethanol water of water, any concentration.
Another object of the present invention is to provide a kind of method utilizing spinning liquid to prepare nano fibrous membrane, comprises the steps: to prepare spinning liquid, and namely nanofiber electrospinning is obtained nano fibrous membrane to gauze surface by electrostatic spinning by spinning liquid.
Further, the preparation process of spinning liquid is: the ratio being 0.1 ~ 100: 0.1 ~ 10 by ratio of weight and the number of copies by polymer and active substance obtains uniform melt by melt blending and is spinning liquid.
Further, the preparation process of spinning liquid is: be dissolved in by film forming polymer in solvent, and obtaining mass concentration is 0.1 ~ 100% film forming polymer solution; In solution, add active substance, mix homogeneously is spinning liquid, and wherein the ratio of weight and number of polymer, active substance, solvent is 0.1 ~ 100: 0.1 ~ 10: 0.1 ~ 100.
Further, the preparation process of spinning liquid is: the ratio being 0.1 ~ 100: 0.1 ~ 10 by ratio of weight and the number of copies by polymer and active substance obtains uniform melt by melt blending, and then be 0.1 ~ 100: 0.1 ~ 10 add medicine by ratio of weight and the number of copies in melt, mix homogeneously obtains spinning liquid.
Further, the preparation process of spinning liquid is: be dissolved in by film forming polymer in solvent, obtaining mass concentration is 0.1 ~ 100% film forming polymer solution, active substance is added in solution, mix homogeneously obtains spinning just liquid, and then be by ratio of weight and the number of copies 0.1 ~ 100: 0.1 ~ 10 weight ratio in spinning just liquid, add medicine, mix homogeneously obtains spinning liquid;
Wherein the ratio of weight and number of polymer, active substance, medicine, solvent is 0.1 ~ 100: 0.1 ~ 10: 0.1 ~ 10: 0.1 ~ 100.
Advantageous Effects of the present invention is:
Pass through kind and the addition of regulating drug and active substance in the present invention, its whitening, moisturizing, antioxidation, radiation-resistant effect can be changed; By controlling the bulk density of nanofiber diameter and fiber, release time and the burst size of active substance and medicine in fibrous membrane can be controlled.
Adopt film forming polymer and the blended obtained spinning liquid of active substance, preparing process is simple, efficiency is high, is suitable for electrostatic spinning, to electrospinning device without particular/special requirement, and good spinning property.The fibrous membrane made uses as facial film, active substance nano-particle diameter is much smaller than pore dia, directly suck by pore, promote the metabolism of tyrosine and tryptophan in aminoacid, extend the human body life-span, strengthen the human body anti-stress ability of environment and immunity to external world, the precipitation of dermal melanin can be reduced, thus reduce black speck and freckle, play skin-whitening, moisturizing and antioxidative effect, there is breathability, not cutaneous eupnea, can apply for a long time, efficiency is high, good absorbing.
Nano fibrous membrane specific surface area is large, and porosity is high, is applied on facial film, can not cutaneously breathe; Secondly, active substance exists with nano level form, absorbs by skin pore, and utilization rate is large, and production cost is reduced, and production technology is simple, quick; Be attached to by facial film after on skin, facial film can become transparence and not drop, and service time is long, and absorption efficiency is high, regulates the content energy Co ntrolled release speed of active substance, reaches deep layer nursing role; On the normal activity of people without impact, after facial film uses, easily remove, the material biological degradability of facial film is good, environmentally safe.
Detailed description of the invention
Below in conjunction with the embodiment of the present invention, be clearly and completely described the technical scheme in the embodiment of the present invention, obviously, described embodiment is only the present invention's part embodiment, instead of whole embodiments.Based on the embodiment in the present invention, those of ordinary skill in the art, not making the every other embodiment obtained under creative work prerequisite, belong to the scope of protection of the invention.
Embodiment 1
A kind of spinning liquid and the method for the preparation of nano fibrous membrane thereof:
By polymer and active substance in 0.1 ~ 100: 0.1 ~ 10 ratio obtain uniform melt by melt blending and be spinning liquid;
Wherein, film forming polymer is made up of polyvinylpyrrolidone, and active substance is made up of D-lactic acid;
Above-mentioned spinning liquid sucks at 18KV voltage in needle tubing, and spinning head and take-up reel distance 17cm, inject speed 0.06mm/min spinning and obtain polymer nanofibre film.
Embodiment 2:
A kind of spinning liquid and the method for the preparation of nano fibrous membrane thereof:
Take 1.60g dissolution of polymer and be mixed with 8% solution in deionized water; Add 0.20g active substance in a polymer solution, stir obtained spinning liquid;
Wherein, film forming polymer is made up of polyvinyl alcohol, and active substance is made up of D-lactic acid;
Above-mentioned spinning liquid sucks at 20KV voltage in needle tubing, and spinning head and take-up reel distance 18.5cm, inject speed 0.06mm/min spinning and obtain nano fibrous membrane.
Embodiment 3:
A kind of spinning liquid and the method for the preparation of nano fibrous membrane thereof:
The ratio being 0.1 ~ 100: 0.1 ~ 10 by weight by polymer and active substance obtains uniform melt by melt blending, and then is 0.1 ~ 100: 0.1 ~ 10 add medicine by weight in melt, and mix homogeneously obtains spinning liquid;
Wherein, film forming polymer is made up of polyvinyl formal, and active substance is made up of beta glucan;
Wherein, medicine is made up of erythromycin;
Above-mentioned spinning liquid sucks at 20KV voltage in needle tubing, and spinning head and take-up reel distance 18.5cm, inject speed 0.06mm/min spinning and obtain nano fibrous membrane.
Embodiment 4
A kind of spinning liquid and the method for the preparation of nano fibrous membrane thereof:
Film forming polymer is dissolved in solvent, obtaining mass concentration is 2 ~ 30% film forming polymer solution, in solution, add active substance, mix homogeneously obtains spinning just liquid, and then by 0.1 ~ 100: 0.1 ~ 10 weight ratio in spinning just liquid, add that medicament mixed is even must spinning liquid; Wherein the ratio of weight and number of active substance, polymer, solvent is 0.1 ~ 100: 0.1 ~ 10: 1 ~ 100;
Wherein, film forming polymer is made up of polyvinyl formal-acetal, and active substance is made up of carbamide;
Wherein, medicine is made up of Roxithromycin;
Above-mentioned spinning liquid sucks at 20KV voltage in needle tubing, and spinning head and take-up reel distance 18.5cm, inject speed 0.06mm/min spinning and obtain nano fibrous membrane.
Embodiment 5:
A kind of spinning liquid and the method for the preparation of nano fibrous membrane thereof:
Take 1.60g dissolution of polymer and be mixed with 8% solution in deionized water; Add 1.60g active substance in a polymer solution, stir;
Wherein, film forming polymer is made up of polyvinyl acetal, and active substance is made up of collagen protein;
Above-mentioned spinning liquid sucks at 20KV voltage in needle tubing, and spinning head and take-up reel distance 18.5cm, inject speed 0.06mm/min spinning and obtain nano fibrous membrane.
Embodiment 6:
A kind of spinning liquid and the method for the preparation of nano fibrous membrane thereof:
Take 1.60g dissolution of polymer and be mixed with 8% solution in ethanol; Add 1.60g active substance in a polymer solution, stir;
Wherein, film forming polymer is made up of polyvinyl formal, and active substance is made up of vitamin B;
Above-mentioned spinning liquid sucks at 20KV voltage in needle tubing, and spinning head and take-up reel distance 18.5cm, inject speed 0.06mm/min spinning and obtain nano fibrous membrane.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (10)
1. a spinning liquid, is characterized in that, described spinning liquid comprises film forming polymer and active substance, and wherein film forming polymer and active substance ratio of weight and number are 0.1 ~ 100: 0.1 ~ 10.
2. spinning liquid according to claim 1, it is characterized in that, also comprise medicine and solvent, wherein the parts by weight of film forming polymer, active substance, medicine and solvent are 0.1 ~ 100: 0.1 ~ 10: 0.1 ~ 10: 0.1 ~ 100;
Wherein, medicine is by one or both in erythromycin, Roxithromycin, chlorphenamine maleate, econazole nitrate, dexamethasone acetate, momestasone furoate and form above.
3. spinning liquid according to claim 1 or 2, it is characterized in that, described film forming polymer by polyvinylpyrrolidone, polyvinyl alcohol, soluble cellulose, polyvinyl butyral resin, polyvinyl formal, polyvinyl acetal, in polyvinyl formal-acetal one or both and form above.
4. spinning liquid according to claim 1 or 2, it is characterized in that, described active substance is by one or both in D-lactic acid, amino acid humectant, nicotiamide, vitamin C, vitamin A, vitamin B, watermiscible vitamin E, 1,3 butylene glycol, carbamide, reed fragrant plant glue, beta glucan, hyaluronic acid, trehalose, collagen protein, carbamide and form above.
5. spinning liquid according to claim 2, it is characterized in that, described solvent is the ethanol water of water, any concentration.
6. utilize spinning liquid to prepare the method for nano fibrous membrane, it is characterized in that, comprise the steps: to prepare spinning liquid, namely nanofiber electrospinning is obtained nano fibrous membrane to gauze surface by electrostatic spinning by spinning liquid.
7. utilize spinning liquid to prepare the method for nano fibrous membrane according to claim 6, it is characterized in that, the preparation process of spinning liquid is: the ratio being 0.1 ~ 100: 0.1 ~ 10 by ratio of weight and the number of copies by polymer and active substance obtains uniform melt by melt blending and is spinning liquid.
8. utilize spinning liquid to prepare the method for nano fibrous membrane according to claim 6, it is characterized in that, the preparation process of spinning liquid is: be dissolved in by film forming polymer in solvent, and obtaining mass concentration is 0.1 ~ 100% film forming polymer solution; In solution, add active substance, mix homogeneously is spinning liquid, and wherein the ratio of weight and number of polymer, active substance, solvent is 0.1 ~ 100: 0.1 ~ 10: 0.1 ~ 100.
9. utilize spinning liquid to prepare the method for nano fibrous membrane according to claim 6, it is characterized in that, the preparation process of spinning liquid is: the ratio being 0.1 ~ 100: 0.1 ~ 10 by ratio of weight and the number of copies by polymer and active substance obtains uniform melt by melt blending, and then be 0.1 ~ 100: 0.1 ~ 10 add medicine by ratio of weight and the number of copies in melt, mix homogeneously obtains spinning liquid.
10. utilize spinning liquid to prepare the method for nano fibrous membrane according to claim 6, it is characterized in that, the preparation process of spinning liquid is: be dissolved in by film forming polymer in solvent, obtaining mass concentration is 0.1 ~ 100% film forming polymer solution, active substance is added in solution, mix homogeneously obtains spinning just liquid, and then be by ratio of weight and the number of copies 0.1 ~ 100: 0.1 ~ 10 weight ratio in spinning just liquid, add medicine, mix homogeneously obtains spinning liquid;
Wherein the ratio of weight and number of polymer, active substance, medicine, solvent is 0.1 ~ 100: 0.1 ~ 10: 0.1 ~ 10: 0.1 ~ 100.
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Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105437667A (en) * | 2016-01-08 | 2016-03-30 | 清华大学 | Preparation method of composite base material for facial masks |
| CN109234827A (en) * | 2018-09-26 | 2019-01-18 | 冷秀红 | A kind of preparation method of the face paper using the siliceous binding material of rose-red |
| CN110251405A (en) * | 2019-05-24 | 2019-09-20 | 西施兰（南阳）药业股份有限公司 | A kind of antipollution facial mask and preparation method thereof containing herbal ingredients |
| CN110438665A (en) * | 2019-08-07 | 2019-11-12 | 山东省医学科学院药物研究所（山东省抗衰老研究中心、山东省新技术制药研究所） | A kind of preparation method of self-supporting solid-state multicomponent facial mask |
| CN110735230A (en) * | 2019-11-13 | 2020-01-31 | 生纳科技(上海)有限公司 | water-resistant polyvinyl alcohol nanofiber membrane, preparation method thereof and composite filter material |
| CN111135119A (en) * | 2020-01-16 | 2020-05-12 | 华南协同创新研究院 | PVA nanofiber mask with slow release effect and preparation method and application thereof |
| CN112294694A (en) * | 2020-11-04 | 2021-02-02 | 河北润达环保科技有限公司 | Invisible mask and special portable electrostatic spinning equipment thereof |
| CN112481738A (en) * | 2020-10-26 | 2021-03-12 | 杭州乐铭科技有限公司 | Hyaluronic acid fiber and production process thereof |
| CN112515976A (en) * | 2020-12-11 | 2021-03-19 | 上海纳米技术及应用国家工程研究中心有限公司 | Preparation method of nano dry facial mask |
| CN114939114A (en) * | 2022-05-31 | 2022-08-26 | 北京化工大学 | Melt electrostatic spinning transdermal patch and production process thereof |
| CN117100621A (en) * | 2023-10-24 | 2023-11-24 | 山东一飞环保材料科技有限公司 | Antibacterial nanofiber dry mask and preparation method thereof |
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Cited By (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105437667A (en) * | 2016-01-08 | 2016-03-30 | 清华大学 | Preparation method of composite base material for facial masks |
| CN109234827A (en) * | 2018-09-26 | 2019-01-18 | 冷秀红 | A kind of preparation method of the face paper using the siliceous binding material of rose-red |
| CN110251405A (en) * | 2019-05-24 | 2019-09-20 | 西施兰（南阳）药业股份有限公司 | A kind of antipollution facial mask and preparation method thereof containing herbal ingredients |
| CN110251405B (en) * | 2019-05-24 | 2023-12-26 | 西施兰（南阳）药业股份有限公司 | A pollution-resistant facial mask containing herbal components and its preparation method |
| CN110438665A (en) * | 2019-08-07 | 2019-11-12 | 山东省医学科学院药物研究所（山东省抗衰老研究中心、山东省新技术制药研究所） | A kind of preparation method of self-supporting solid-state multicomponent facial mask |
| CN110735230B (en) * | 2019-11-13 | 2022-01-11 | 生纳科技(上海)有限公司 | Water-resistant polyvinyl alcohol nanofiber membrane, preparation method thereof and composite filter material |
| CN110735230A (en) * | 2019-11-13 | 2020-01-31 | 生纳科技(上海)有限公司 | water-resistant polyvinyl alcohol nanofiber membrane, preparation method thereof and composite filter material |
| CN111135119A (en) * | 2020-01-16 | 2020-05-12 | 华南协同创新研究院 | PVA nanofiber mask with slow release effect and preparation method and application thereof |
| CN112481738A (en) * | 2020-10-26 | 2021-03-12 | 杭州乐铭科技有限公司 | Hyaluronic acid fiber and production process thereof |
| CN112294694A (en) * | 2020-11-04 | 2021-02-02 | 河北润达环保科技有限公司 | Invisible mask and special portable electrostatic spinning equipment thereof |
| CN112294694B (en) * | 2020-11-04 | 2023-03-21 | 河北润达环保科技有限公司 | Invisible mask and special portable electrostatic spinning equipment thereof |
| CN112515976A (en) * | 2020-12-11 | 2021-03-19 | 上海纳米技术及应用国家工程研究中心有限公司 | Preparation method of nano dry facial mask |
| CN114939114A (en) * | 2022-05-31 | 2022-08-26 | 北京化工大学 | Melt electrostatic spinning transdermal patch and production process thereof |
| CN117100621A (en) * | 2023-10-24 | 2023-11-24 | 山东一飞环保材料科技有限公司 | Antibacterial nanofiber dry mask and preparation method thereof |
| CN117100621B (en) * | 2023-10-24 | 2024-01-09 | 山东一飞环保材料科技有限公司 | Antibacterial nanofiber dry mask and preparation method thereof |
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Application publication date: 20141217 |