CN106480517A - A kind of sodium alginate nano fiber and its scale electro spinning method for preparing and application - Google Patents
A kind of sodium alginate nano fiber and its scale electro spinning method for preparing and application Download PDFInfo
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Abstract
The invention discloses a kind of sodium alginate nano fiber and its scale electro spinning method for preparing and application，The sodium alginate micro nanometer fiber is obtained by air-flow auxiliary electrostatic spin processes，In the micro nanometer fiber, the content of sodium alginate is more than 75%，Fibre diameter is 50～900nm，Sodium alginate nano fiber is obtained by air-flow auxiliary electrostatic spinning process，There is provided in spinning process and spinning jet direction identical air-flow by aerogenesis mechanism，To accelerate the evaporation of solvent，Promote the formation of spinning，Preparation method is simple，Spinning condition requires low，Yield is high，Matters are mass produced，Spinning forerunner's formula of liquid is simple，Crosslinking agent and stimulation or poisonous solvent need not be added，In gained nanofiber, the content of sodium alginate is high，In bioengineered tissue material、The application aspect in wound repair materials or beauty and make-up field has significant advantage.
Description
Technical field
The present invention relates to a kind of sodium alginate nano fiber and its scale electro spinning method for preparing and application, category
In micro-nano material field.
Background technology
Sodium alginate (SodiumAlginate) is a kind of linear polyuronide extracted from natural brown algae,
Molecular backbone relies on α -1,4- by a-L- mannuronic acid (M unit) with b-D- guluronic acid (G unit)
The bonded and copolymer that be made up of GM, MM and GG fragment of different proportion of glucosides.As a kind of line
Shape, nontoxic natural polymer polyelectrolyte, sodium alginate have with low cost, raw material sources extensively,
The features such as good biological degradability and biocompatibility, drug delivery system, field of tissue engineering technology and
Pharmaceutical field has a wide range of applications.At present, the gelatinizing agent that prepared as raw material with sodium alginate, thickening
Agent, stabilizer, emulsifying agent etc. are largely used to food industry, and such as cold drink, cake, candy, refrigeration is protected
Fresh etc..In recent years, the sodium alginate fiber non-woven (average fibre diameter for being prepared by wet spinning
At 10 μm or so) it is widely used on medical dressing, compared with traditional cotton gauze, marine alga
Sour sodium gauze hygroscopicity is high, and anthemorrhagic performance is good, and can form one layer of hydrogel in wound surface, can give
The healing environment of wound one moistening of offer, and growth breeding and the wound healing of cell can be promoted, in height
With very high using value in the production of hygroscopicity medical dressing.Additionally, sodium alginate fiber have excellent
Good fire retardation, and its fiber shape can be kept after high temperature sintering, it is adaptable to resistance to combustion, fire-retardant
The production of textile.However, sodium alginate fiber is typically with wet method and dry spinning to prepare at present
Production, fibre diameter prepared by the method arrive hundreds of micron at several microns, and fibre diameter is thicker, it is impossible to very
Good adapts to biomedical, requirement of the field of tissue engineering technology to fibre diameter, and using wet method and dry method
Sodium alginate fiber prepared by spinning can be just used after needing complicated subsequent chemistry crosslinking working process.
Electrostatic spinning technique is to prepare one of most simple efficient method of 1-dimention nano fiber, with Conventional nano
Material preparation technology is compared, with processing unit (plant) simple, raw material sources are extensive, cost of spinning is cheap, can
The advantages such as prepare with scale, are subject to widely studied report both domestic and external in recent years.Using electrostatic spinning technique
Nanofiber prepared by processing has the physico of high-specific surface area, larger length/diameter ratio and uniqueness
The good characteristics such as property are learned, is led in bioengineered tissue, wound dressing, filter protection, medicament slow release etc.
Domain shows great application potential.Method of electrostatic spinning principle is very simple, sketches and is：In high voltage electric field
Under effect, the polymer solution at spinning nozzle or melt are subject to the effect of electrostatic field force and eject shape
Become jet, jet occurs in dropping process to cleave and stretches, while solvent volatilization, forms nanofiber
Curing molding is simultaneously deposited on collector.But, sodium alginate is prepared using electrostatic spinning technique electrospinning receive
Rice fiber is primarily present problems with：(1) sodium alginate is a kind of anionic polyelectrolyte, and which is water-soluble
Liquid has very high conductivity, in the case of extra electric field, the cation in solution and the oriented phase of anion
The trend of opposite direction movement, in electro-spinning process, it is impossible to keep droplet surface to form stable tangential electric field,
So that tangential electric field force is reduced, taylor cone is caused to be hardly formed jet；(2) sodium alginate soln exists
Under very low concentration, (such as 2% aqueous solution) will produce gel phenomenon, under so low concentration,
The amount of solute seldom, is hardly formed effective fibre structure, only can produce the drop of injection or be embedded in
Chopped fiber in bead string, and concentration slightly improves, and viscosity will increase sharply, and cause spinning solution excessively
Sticky, it is impossible to form solid jet；(3) the G unit in sodium alginate causes its strand to become rigidity to stretch
Exhibition chain, and G unit is combined by double bond, and fixed by hydrogen bond, the molecule of sodium alginate rigidity and stretching, extension
Chain makes its aqueous solution form effective chain entanglement, and under high voltage electric field, jet is easily pulled off, from
And affect electrospinning effect.
In order to solve these problems, scientist has carried out the research of correlation, Chinese patent CN102071497A
A kind of passing through in sodium alginate aqueous solution is reported in " a kind of preparation method of sodium alginate nano fiber "
Minimal amount of bivalent cation is added, a small amount of physical crosslinking point is formed, increase the intermolecular work of sodium alginate
Firmly, successfully solve the problems, such as that hydrojet is dripped and do not form jet in sodium alginate aqueous solution electro-spinning process.
But the small molecule solvents such as the dimethylformamide DMF that the inventive method is added, highly volatile and have certain
Toxicity, limit application of the sodium alginate nano fiber in the higher biomedical aspect of security requirement；
Cui Li et al. exists《Synthetic fiber industry》On the article delivered《The performance of sodium alginate/poly-vinyl alcohol solution
And electrostatic spinning》A kind of preparation method for preparing sodium alginate/polyvinyl alcohol composite micro-nano rice fiber is disclosed,
By the sodium alginate that mass fraction is 2% and the polyvinyl alcohol (PVA) that mass fraction is 8% by certain volume
Than carrying out electrostatic spinning after mixing, when the volume ratio of sodium alginate and PVA is (1/9)～(5/5), it is obtained relatively
Stable composite fibre, but in this composite fibre, the content of sodium alginate is too low so as to application effect
Have a greatly reduced quality, limit its application in biomedical aspect；And alginic acid prepared by above-mentioned preparation method
Sodium nanofiber yield is relatively low, is suitable only for laboratory science research level, it is impossible to meet extensive work
Industryization prepares demand.
Content of the invention
It is an object of the invention to overcome the deficiencies in the prior art, provide a kind of sodium alginate nano fiber and
Its preparation method and application, the sodium alginate nano fiber are obtained by air-flow auxiliary electrostatic spinning process,
Preparation method is simple, and spinning condition requires low, yield height, and suitable for mass production, spinning precursor liquid is joined
Side is simple, need not add crosslinking agent and stimulation or poisonous solvent, sodium alginate in gained nanofiber
Content is high, has in the application aspect of bioengineered tissue material, wound repair materials or beauty and make-up field
There is significant advantage.
To achieve these goals, the technical scheme that the present invention is provided is as follows：
A kind of sodium alginate nano fiber, the sodium alginate micro nanometer fiber is by air-flow auxiliary electrostatic spinning
Method is obtained, and in the micro nanometer fiber, the content of sodium alginate is more than 75%, and fibre diameter is 50～900nm.
Further, in the micro nanometer fiber, the content of sodium alginate is more than 90%, prepares the alginic acid
The spinning precursor liquid of sodium micro nanometer fiber is made up of water, sodium alginate and water-soluble biological high molecular polymer,
The fibre diameter of the sodium alginate micro nanometer fiber is 300-600nm.
Further, the water is distilled water or deionized water, the water-soluble biological high molecular polymer
For polyethylene glycol oxide, polyvinylpyrrolidone, shitosan, hyaluronic acid, gelatin, polyethylene glycol, glue
One or more in former albumen, polyvinyl alcohol.
The invention also discloses the scale electro spinning method for preparing of described sodium alginate nano fiber, including
Following steps：
(1) spinning precursor liquid is prepared：Sodium alginate powder and water-soluble biological high molecular polymer are dissolved
In water, then it is placed on magnetic stirring apparatus and stirs to homogeneous spinning precursor liquid is formed, wherein, sea
The content of mosanom between 0.5%～15% (wt%), water-soluble biological high molecular polymer and marine alga
The mass ratio of sour sodium is 1:3～1:200；
(2) air-flow auxiliary electrospinning prepares nanofiber：The spinning precursor liquid for preparing in step (1) is added
Enter in the feeding cylinder of electrostatic spinning apparatus, the electrostatic spinning apparatus include high voltage power supply and high voltage power supply
The connected spinning nozzle of positive pole and spinning nozzle connection feeding cylinder, be grounded collector and be arranged at spinning
Aerogenesis mechanism around shower nozzle, the aerogenesis mechanism produce and spinning injection direction identical air-flow, adjustment
Spinning nozzle collects the spinning spacing of interpolar with ground connection, arranges spinning voltage and aerogenesis mechanism produces air-flow
Flow velocity, opens aerogenesis mechanism and high voltage power supply, and spinning precursor liquid forms jet in the presence of electric field force,
Solvent volatilization under air-flow booster action, forms sodium alginate nano fiber on collector.
Further, in described step (1) the spinning precursor liquid for configuring the content of sodium alginate 1%～
Between 3% (wt%), water-soluble biological high molecular polymer is 1 with the mass ratio of sodium alginate:10～1:100.
Further, electrostatic spinning apparatus described step (2) also include syringe pump connected with feeding cylinder,
The syringe pump pushes spinning solution to spinning nozzle, and the aerogenesis mechanism is air pump, the giving vent to anger of the air pump
Mouth is located at directly over spinning nozzle jet, airflow direction and spinning injection side that air pump gas outlet is ejected
To identical, syringe pump is provided with the injection pump controller that control spinning precursor liquid advances speed, and air pump is arranged
Air pump controller in control and regulation air-flow velocity.
Further, the feeding cylinder connects multiple spinning nozzles by woven hose, the giving vent to anger of the air pump
Mouthful connection fan housing, spinning nozzle is uniformly distributed below fan housing, the airflow direction ejected by fan housing and spinning
Silk injection direction is identical.
Further, the spinning spacing in described step (2) is 5～50cm, and spinning voltage is 15～40kV,
The propulsion speed of syringe pump is 10 μ L/min～5mL/min, the air-flow velocity 10～200 of air pump injection
L/min.
Further, the water in step (1) is distilled water or deionized water, water-soluble biological polyphosphazene polymer
Compound be polyethylene glycol oxide, polyvinylpyrrolidone, shitosan, hyaluronic acid, gelatin, collagen,
One or more in polyethylene glycol, polyvinyl alcohol.
The sodium alginate nano fiber of the present invention is in bioengineered tissue material, wound repair materials or beauty
Cosmetic field has a wide range of applications, such as wound dressing or face-mask material etc..The material conduct
Wound dressing is applied on wound, and its nanofibrous structures has larger specific surface area and fully can be fitted in
Wound surface, quick absorption wound surface sepage, the moist environment beneficial to wound healing is maintained, is had
Good gas permeability, and can effectively completely cut off extraneous foreign matter and bacterium, meanwhile, the material be sodium alginate with
Water-soluble biological high molecular polymer is combined, and is rich in sodium alginate, during with Wound contact, sodium alginate
Can be fully dissolved out, its effect is given full play to, promote wound healing.
Beneficial effects of the present invention are：The invention provides a kind of sodium alginate nano fiber and its preparation side
Method and application, the sodium alginate nano fiber are obtained by air-flow auxiliary electrostatic spinning process, preparation method
Simply, spinning condition requires low, yield height, and suitable for mass production, spinning forerunner formula of liquid is simple,
Crosslinking agent and stimulation or poisonous solvent need not be added, the content of sodium alginate is high in gained nanofiber,
Have in the application aspect of bioengineered tissue material, wound repair materials or beauty and make-up field significantly excellent
Gesture.Specifically：
(1) sodium alginate nano fiber of the present invention is in preparation process, spinning forerunner's formula of liquid of employing
Simple and safe, only with water as solvent, and other toxic or irritating solvents that undope so that
Sodium alginate nano fiber material obtained in the method has higher security, is more suitably applied to biology
The aspects such as medical science.In order to solve the not volatile problem of aqueous solvent, the present invention is adopted in fiber manufacturing process
The method aided in air-flow, adds during spinning precursor liquid forms jet under electric field force effect
With its injection direction direction identical air-flow, to accelerate the evaporation of solvent, promote the formation of fiber, meanwhile,
Air-flow is contacted to spinning precursor liquid jet, produces the effect of power to which, can auxiliary electric field power effect, promote
Enter the stretching of jet, accelerate the speed of jet, so as to accelerate spinning speed, while it is less to obtain diameter
Sodium alginate nano fiber, meets biomedicine, field of tissue engineering technology to fiber to meet large-scale production
The demand of the sodium alginate nano fiber of the requirement of diameter, makes the material have more preferable application prospect.
(2) solute of spinning precursor liquid is only sodium alginate and minimal amount of water-soluble biological high molecular polymerization
Thing, need not add other crosslinking agents, and in gained fiber, sodium alginate content is high, and material has very well
Biocompatibility, preferably can adapt in bioengineered tissue material, wound repair materials or beauty
The application demand of cosmetic field.
(3) preparation method of the sodium alginate nano fiber of the present invention, the spinning forerunner formula of liquid peace of employing
Complete simple, configuration is convenient, and spinning process is simple to operate, and spinning condition is gentle, without the need at the complicated later stage
Reason can directly obtain sodium alginate nano fiber, and cost of spinning is cheap, quickly can continuously prepare Nanowire
Dimension, and the method for coordinating air-flow auxiliary using many spinning nozzles in a preferred approach, further can accelerate
Spinning speed, improves yield, preferably adapts to the demand of large-scale production sodium alginate nano fiber.
Description of the drawings
The structural representation of many shower nozzles air-flow auxiliary electrostatic device for spinning that Fig. 1 is adopted for the present invention.
The stereoscan photograph of the sodium alginate nano fiber that Fig. 2 is prepared for the present invention.
In figure, 1- high voltage power supply, 2- air pump, 3- syringe pump, 4- feed cylinder, 5- woven hose, 6- spinning nozzle,
7- wire, 8- fan housing, 9- are grounded collector.
Specific embodiment
According to following embodiments, the present invention may be better understood.However, those skilled in the art holds
Readily understood, specific material proportion described by embodiment, process conditions and its result are merely to illustrate this
Invention and should not be also without limitation on the present invention described in detail in claims.
Embodiment 1
A kind of scale electro spinning method for preparing of sodium alginate nano fiber, comprises the following steps：
(1) spinning precursor liquid is prepared：By sodium alginate powder (viscosity 500cps) and polyvinyl pyrrole
Alkanone PVP (relative molecular mass 40000) is dissolved in water, and is then placed on magnetic stirring apparatus and stirs
Mix to homogeneous spinning precursor liquid is formed, wherein, the content of sodium alginate is 0.5% (wt%), polyethylene
Pyrrolidones is 1 with the mass ratio of sodium alginate:20；
(2) air-flow auxiliary electrospinning prepares nanofiber：The spinning precursor liquid for preparing in step (1) is added
Enter in the feeding cylinder of electrostatic spinning apparatus, the electrostatic spinning apparatus include high voltage power supply and high voltage power supply
The feeding cylinder of the connected spinning nozzle of positive pole and spinning nozzle connection, air pump, the gas outlet of air pump is located at
Directly over spinning nozzle jet, the airflow direction that air pump gas outlet is ejected is identical with spinning injection direction,
The spinning spacing that spinning nozzle collects interpolar with ground connection is 5cm, and spinning voltage is 15kV, and air pump is produced
The flow velocity 10L/min of air-flow, opens air pump and high voltage power supply, and spinning precursor liquid is in the presence of electric field force
Jet is formed, solvent evaporation under air-flow booster action forms sodium alginate nano fiber on collector,
Gained sodium alginate nano fiber average diameter is in 220 ± 40nm.
Embodiment 2
A kind of scale electro spinning method for preparing of sodium alginate nano fiber, comprises the following steps：
(1) spinning precursor liquid is prepared：By sodium alginate powder (viscosity 300cps) and PVAC polyvinylalcohol
(relative molecular mass 105000) is dissolved in 80 DEG C of heating water baths of deionized water, is then placed on magnetic force
Stir on agitator to homogeneous spinning precursor liquid is formed, wherein, the content of sodium alginate is 15% (wt%),
Polyvinyl alcohol is 1 with the mass ratio of sodium alginate:3；
(2) air-flow auxiliary electrospinning prepares nanofiber：The spinning precursor liquid for preparing in step (1) is added
Enter in the feeding cylinder of electrostatic spinning apparatus, the electrostatic spinning apparatus include high voltage power supply and high voltage power supply
The connected spinning nozzle of positive pole and the feeding cylinder that spinning nozzle connects syringe pump connected with feeding cylinder,
Air pump, the gas outlet of air pump are located at directly over spinning nozzle jet, the air-flow that air pump gas outlet is ejected
Direction is identical with spinning injection direction, and the spinning spacing that spinning nozzle collects interpolar with ground connection is 50cm, spins
Filament voltage is 40kV, and air pump produces the flow velocity 40L/min of air-flow, and syringe pump pushes spinning to spinning nozzle
Liquid, the propulsion speed of syringe pump is 10 μ L/min, opens air pump, high voltage power supply and syringe pump, before spinning
Drive liquid jet is formed in the presence of electric field force, solvent evaporation shape on collector under air-flow booster action
Become sodium alginate nano fiber, gained sodium alginate nano fiber average diameter is in 830 ± 46nm.
Embodiment 3
A kind of scale electro spinning method for preparing of sodium alginate nano fiber, comprises the following steps：
(1) spinning precursor liquid is prepared：By sodium alginate powder (viscosity 400cps) and polyethylene glycol oxide
PEO (relative molecular mass 5000000) is dissolved in water, and is then placed on magnetic stirring apparatus and stirs
To homogeneous spinning precursor liquid is formed, wherein, the content of sodium alginate is 9% (wt%), polyethylene glycol oxide
Mass ratio with sodium alginate is 1:25；
(2) air-flow auxiliary electrospinning prepares nanofiber：The spinning precursor liquid for preparing in step (1) is added
Enter in the feeding cylinder of electrostatic spinning apparatus, the electrostatic spinning apparatus are the air-flow auxiliary electrostatic spinning of many shower nozzles
Device, apparatus structure schematic diagram as shown in figure 1, the device includes high voltage power supply 1, with high voltage power supply 1 just
Pole passes through connected 7 spinning nozzles 6 of wire 7, the feeding cylinder that spinning nozzle 6 is connected by woven hose 5
4, feeding cylinder 4 connects syringe pump 3, and the device is additionally provided with air pump 2, the gas outlet connection of the air pump 2
Fan housing 8,7 spinning nozzles 6 are uniformly distributed below fan housing 8, the airflow direction ejected by fan housing 8
Identical with spinning injection direction, the spinning spacing between spinning nozzle 6 and ground connection collector 9 is 30cm, spins
Filament voltage is 35kV, and air pump produces the flow velocity 80L/min of air-flow, and syringe pump pushes spinning to spinning nozzle
Liquid, the propulsion speed of syringe pump is 180 μ L/min, opens air pump, high voltage power supply and syringe pump, spinning
Precursor liquid forms jet in the presence of electric field force, and under air-flow booster action, solvent is evaporated on collector
Sodium alginate nano fiber is formed, gained sodium alginate nano fiber average diameter is in 540 ± 50nm, gained
The stereoscan photograph of sodium alginate nano fiber is as shown in Figure 2.
Embodiment 4
A kind of scale electro spinning method for preparing of sodium alginate nano fiber, comprises the following steps：
(1) spinning precursor liquid is prepared：By sodium alginate powder (viscosity 400cps) and polyethylene glycol oxide
PEO (relative molecular mass 5000000) is dissolved in water, and is then placed on magnetic stirring apparatus and stirs
To homogeneous spinning precursor liquid is formed, wherein, the content of sodium alginate is 13% (wt%), polyoxyethylene
Alkene is 1 with the mass ratio of sodium alginate:200；
(2) air-flow auxiliary electrospinning prepares nanofiber：The spinning precursor liquid for preparing in step (1) is added
Enter in the feeding cylinder of electrostatic spinning apparatus, the electrostatic spinning apparatus are the air-flow auxiliary electrostatic spinning of many shower nozzles
Device, apparatus structure schematic diagram as shown in figure 1, the device includes high voltage power supply 1, with high voltage power supply 1 just
Pole passes through connected 20 spinning nozzles 6 of wire 7, the charging that spinning nozzle 6 is connected by woven hose 5
Cylinder 4, feeding cylinder 4 connect syringe pump 3, and the device is additionally provided with air pump 2, and the gas outlet of the air pump 2 connects
8,20 spinning nozzles 6 of cover of giving a dinner for a visitor from afar are uniformly distributed below fan housing 8, the air-flow ejected by fan housing 8
Direction is identical with spinning injection direction, and the spinning spacing between spinning nozzle 6 and ground connection collector 9 is 20cm,
Spinning voltage is 25kV, and air pump produces the flow velocity 200L/min of air-flow, and syringe pump is pushed to spinning nozzle
Spinning solution, the propulsion speed of syringe pump is 5mL/min, opens air pump, high voltage power supply and syringe pump, spins
Silk precursor liquid forms jet in the presence of electric field force, and under air-flow booster action, solvent is evaporated in collector
Upper formation sodium alginate nano fiber, gained sodium alginate nano fiber average diameter are in 340 ± 40nm, every
Hour production 200 ± 35g of sodium alginate nano fiber.
The above, only the explanation embodiment of the present invention, not any to the present invention in form and substantive
On restriction, it is noted that for those skilled in the art, without departing from side of the present invention
On the premise of method, some improvement that makes and supplement also should be regarded as protection scope of the present invention.All it is familiar with sheet
Technical professional, without departing from the spirit and scope of the present invention, using disclosed above
Technology contents make a little change, modification with develop equivalent variations, be the equivalent reality of the present invention
Apply example；Meanwhile, any equivalent variations that all substantial technological according to the present invention are done to above-described embodiment
Change, modify and develop, all still fall within the scope of technical scheme.
Claims (10)
1. a kind of sodium alginate nano fiber, it is characterised in that the sodium alginate micro nanometer fiber is by air-flow
Auxiliary electrostatic spin processes are obtained, and in the micro nanometer fiber, the content of sodium alginate is more than 75%, fibre diameter
For 50～900 nanometers.
2. a kind of sodium alginate nano fiber as claimed in claim 1, it is characterised in that described micro-nano
In fiber, the content of sodium alginate is more than 90%, prepare the spinning precursor liquid of the sodium alginate micro nanometer fiber by
Water, sodium alginate and water-soluble polymer constitute, and the fibre diameter of the sodium alginate micro nanometer fiber is
300-600 nanometer.
3. a kind of sodium alginate nano fiber as claimed in claim 2, it is characterised in that the water is for steaming
Distilled water or deionized water, the water-soluble biological high molecular polymer are polyethylene glycol oxide, polyvinylpyrrolidine
One kind or many in ketone, shitosan, hyaluronic acid, gelatin, polyethylene glycol, collagen, polyvinyl alcohol
Kind.
4. prepared by the scale electrospinning of sodium alginate nano fiber as claimed any one in claims 1 to 3
Method, it is characterised in that comprise the following steps：
(1) spinning precursor liquid is prepared：Sodium alginate powder and water-soluble biological high molecular polymer are dissolved in
In water, then it is placed on magnetic stirring apparatus and stirs to forming homogeneous spinning precursor liquid, wherein, alginic acid
The mass percent of sodium is 0.5%～15% (wt%), the matter of water-soluble biological high molecular polymer and sodium alginate
Amount is than being 1:3～1:200；
(2) air-flow auxiliary electrospinning prepares nanofiber：The spinning precursor liquid for preparing in step (1) is added
In the feeding cylinder of electrostatic spinning apparatus, the electrostatic spinning apparatus include high voltage power supply and high-voltage power cathode
Connected spinning nozzle and spinning nozzle connection feeding cylinder, be grounded collector and be arranged at spinning nozzle week
The aerogenesis mechanism for enclosing, the aerogenesis mechanism produce and spinning injection direction identical air-flow, adjust spinning nozzle
The spinning spacing of interpolar is collected with ground connection, the flow velocity that spinning voltage and aerogenesis mechanism produce air-flow is set, open
Aerogenesis mechanism and high voltage power supply, spinning precursor liquid form jet in the presence of electric field force, make in air-flow auxiliary
Volatilized with lower solvent, sodium alginate nano fiber is formed on collector.
5. the scale electro spinning method for preparing of sodium alginate nano fiber as claimed in claim 4, its feature
It is, in the spinning precursor liquid that step (1) configures, the mass percent of sodium alginate is 1%～10%
(wt%), water-soluble polymer is 1 with the mass ratio of sodium alginate:10～1:100.
6. the scale electro spinning method for preparing of sodium alginate nano fiber as claimed in claim 4, its feature
It is, the electrostatic spinning apparatus of step (2) also include syringe pump connected with feeding cylinder, the injection
Pump pushes spinning solution to spinning nozzle, and the aerogenesis mechanism is air pump, and the gas outlet of the air pump is located at spinning
Directly over shower nozzle jet, the airflow direction that air pump gas outlet is ejected is identical with spinning injection direction, injection
Pump is provided with the injection pump controller that control spinning precursor liquid advances speed, and air pump is arranged at control and regulation air-flow
The air pump controller of flow velocity.
7. the scale electro spinning method for preparing of sodium alginate nano fiber as claimed in claim 6, described enter
Barrel connects multiple spinning nozzles by woven hose, and the gas outlet connection fan housing of the air pump, spinning nozzle exist
It is uniformly distributed below fan housing, the airflow direction ejected by fan housing is identical with spinning injection direction.
8. the scale electro spinning method for preparing of sodium alginate nano fiber as claimed in claim 7, its feature
It is, the spinning spacing in step (2) is 5～50 centimetres, spinning voltage is 15～40 kilovolts, note
The propulsion speed for penetrating pump is 10 mul/min～5 ml/min, the air-flow velocity 10～200 of air pump injection
Liter/min.
9. the scale electro spinning method for preparing of sodium alginate nano fiber as described in claim 4, its are special
Levy and be, the water in step (1) is distilled water or deionized water, water-soluble biological high molecular polymer
For polyethylene glycol oxide, polyvinylpyrrolidone, shitosan, hyaluronic acid, gelatin, collagen, poly- second
One or more in glycol, polyvinyl alcohol.
10. the sodium alginate nano fiber as described in claims 1 to 3 is in bioengineered tissue material, wound
Repair materials or the application in beauty and make-up field.
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| CN107794601A (en) * | 2017-09-12 | 2018-03-13 | 浙江理工大学 | For preparing spinning solution and its application of high marine alga content nanofiber |
| CN107823704A (en) * | 2017-12-28 | 2018-03-23 | 广东泰宝医疗器械技术研究院有限公司 | A kind of paradenlal tissue regeneration repair membrane and preparation method thereof |
| CN108295047A (en) * | 2018-01-15 | 2018-07-20 | 嘉兴学院 | A kind of preparation method for the micro-/ nano particle and its injection loading chondroitin sulfate |
| CN109252246A (en) * | 2018-08-01 | 2019-01-22 | 青岛海赛尔新材料科技有限公司 | A kind of water soluble algae silicate antibiosis fiber and preparation method thereof |
| CN109260507A (en) * | 2018-10-31 | 2019-01-25 | 广东泰宝医疗科技股份有限公司 | A kind of high liquid-absorbing fibroin albumen haemostatic membrane and preparation method thereof |
| CN112760811A (en) * | 2020-12-30 | 2021-05-07 | 中国热带农业科学院南亚热带作物研究所 | Chitosan-alginate composite nanofiber membrane and preparation method and application thereof |
| CN113195802A (en) * | 2018-11-01 | 2021-07-30 | Emd密理博公司 | Efficient production of nanofiber structures |
| CN113249876A (en) * | 2021-06-10 | 2021-08-13 | 上海科技大学 | Ion conductor material and preparation method and application thereof |
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| CN112760811A (en) * | 2020-12-30 | 2021-05-07 | 中国热带农业科学院南亚热带作物研究所 | Chitosan-alginate composite nanofiber membrane and preparation method and application thereof |
| CN113249876A (en) * | 2021-06-10 | 2021-08-13 | 上海科技大学 | Ion conductor material and preparation method and application thereof |
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