CN103442735B - 用于减轻技术领域中所不希望的医学状况的有效要素 - Google Patents
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Abstract
Description
Claims (19)
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JP5042215B2 (ja) | 2005-05-26 | 2012-10-03 | ニューロン システムズ, インコーポレイテッド | 網膜疾患を処置するための組成物および方法 |
CA2782015C (en) | 2009-12-11 | 2020-08-25 | Neuron Systems, Inc. | Topical ophthalmic compositions and methods for the treatment of macular degeneration |
WO2014100425A1 (en) | 2012-12-20 | 2014-06-26 | Aldexa Therapeutics, Inc. | Peri-carbinols |
EP2948149A4 (en) | 2013-01-23 | 2016-12-14 | Aldeyra Therapeutics Inc | BY TOXIC ALDEHYDIC DISEASES AND TREATMENT |
JP6266023B2 (ja) | 2013-01-25 | 2018-01-24 | アルデイラ セラピューティクス, インコーポレイテッド | 黄斑変性症の処置における新規トラップ |
WO2016153874A1 (en) * | 2015-03-20 | 2016-09-29 | Purdue Research Foundation | Compositions and methods for treating parkinson's disease |
KR102664994B1 (ko) | 2015-08-21 | 2024-05-13 | 알데이라 테라퓨틱스, 아이엔씨. | 중수소화 화합물 및 이의 용도 |
JP7116490B2 (ja) | 2016-05-09 | 2022-08-10 | アルデイラ セラピューティクス, インコーポレイテッド | 眼の炎症性障害および疾患の組合せ処置 |
EP3596040B1 (en) | 2017-03-16 | 2023-10-11 | Aldeyra Therapeutics, Inc. | Polymorphic salt of 6-chloro-3-amino-2(2-hydroxypropyl)quinoline and uses thereof |
WO2018172422A1 (en) * | 2017-03-21 | 2018-09-27 | Pvac Medical Technologies Ltd | Method of preserving erythrocytes using pvac |
CN111225561A (zh) * | 2017-07-18 | 2020-06-02 | Pvac医药科技有限公司 | 抗细菌物质及其组合物、使用其的医学和非医学用途以及包含所述物质和组合物的产物 |
CN111356451A (zh) | 2017-10-10 | 2020-06-30 | 奥尔德拉医疗公司 | 炎性病症的治疗 |
EP3833660A4 (en) | 2018-08-06 | 2022-05-11 | Aldeyra Therapeutics, Inc. | POLYMORPHIC COMPOUNDS AND THEIR USES |
CN113056353B (zh) | 2018-09-25 | 2022-11-01 | 奥尔德拉医疗公司 | 用于治疗干眼病的调配物 |
JP2022526917A (ja) | 2019-03-26 | 2022-05-27 | アルデイラ セラピューティクス, インコーポレイテッド | 眼科用製剤およびその使用 |
JP2022530967A (ja) | 2019-05-02 | 2022-07-05 | アルデイラ セラピューティクス, インコーポレイテッド | 多形化合物およびその使用 |
WO2020223717A1 (en) | 2019-05-02 | 2020-11-05 | Aldeyra Therapeutics, Inc. | Process for preparation of aldehyde scavenger and intermediates |
CN110540606A (zh) * | 2019-08-19 | 2019-12-06 | 广西医科大学 | 一种羰基化蛋白清除剂及其制备方法 |
CN110624422A (zh) * | 2019-08-19 | 2019-12-31 | 广西医科大学 | 一种用于清除羰基化蛋白的透析膜及其制备方法 |
CN110721663A (zh) * | 2019-11-06 | 2020-01-24 | 广西医科大学 | 一种改性纤维素粒子及其制备方法和应用 |
AU2020387535A1 (en) * | 2019-11-21 | 2022-05-26 | Cremed AB (publ) | Carbazate-activated polyvinyl alcohol (PVAC) as a polymer-based antitumoral agent |
WO2021185844A1 (en) * | 2020-03-16 | 2021-09-23 | Pvac Medical Technologies Ltd | Use of substance and pharmaceutical composition thereof, and medical treatments or uses thereof |
WO2021233534A1 (en) * | 2020-05-20 | 2021-11-25 | Pvac Medical Technologies Ltd | Use of substance and pharmaceutical composition thereof, and medical treatments or uses thereof |
SE544131C2 (en) * | 2020-03-16 | 2022-01-04 | Pvac Medical Tech Ltd | Use of substance and pharmaceutical composition thereof, and medical treatments or uses thereof |
SE2050387A1 (en) * | 2020-04-06 | 2021-10-07 | Pvac Medical Tech Ltd | Labelled substance and methods of detection of inflammation and infection using said substance |
WO2021209645A1 (en) | 2020-04-17 | 2021-10-21 | Pvac Medical Technologies Ltd | Composition for treating keratin tissue |
WO2021231792A1 (en) | 2020-05-13 | 2021-11-18 | Aldeyra Therapeutics, Inc. | Pharmaceutical formulations and uses thereof |
WO2022191759A1 (en) | 2021-03-09 | 2022-09-15 | Cremed AB (publ) | A polymer-based carbonyl scavenger for detection and treatment of ischemic injuries |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009108100A1 (en) * | 2008-02-29 | 2009-09-03 | Ipr-Systems Sweden Ab | Composition for the formation of gels |
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US6630457B1 (en) * | 1998-09-18 | 2003-10-07 | Orthogene Llc | Functionalized derivatives of hyaluronic acid, formation of hydrogels in situ using same, and methods for making and using same |
WO2003055487A1 (en) * | 2002-01-04 | 2003-07-10 | The University Of Adelaide | METHOD OF CONTROLLING DAMAGE MEDIATED BY α, β- UNSATURATED ALDEHYDES |
US7368169B2 (en) * | 2003-12-01 | 2008-05-06 | Rutgers, The State University Of New Jersey | Hydrazide compounds with angiogenic activity |
WO2006002473A1 (en) | 2004-07-02 | 2006-01-12 | Adelaide Research & Innovation Pty Ltd | Method of controlling damage mediated by alpha, beta-unsaturated aldehydes |
EP2038309A2 (en) * | 2006-07-11 | 2009-03-25 | University of Utah Research Foundation | Macromolecules modified with electrophilic groups and methods of making and using thereof |
WO2009091992A1 (en) | 2008-01-16 | 2009-07-23 | Purdue Research Foundation | Repairing damaged nervous system tissue with nanoparticles |
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WO2009108100A1 (en) * | 2008-02-29 | 2009-09-03 | Ipr-Systems Sweden Ab | Composition for the formation of gels |
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