CN103405738A - 一种治疗慢性胆囊炎的药物组合物 - Google Patents
一种治疗慢性胆囊炎的药物组合物 Download PDFInfo
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Abstract
本发明涉及一种治疗慢性胆囊炎的药物组合物，该组合物由如下重量份的中药材原料制备而成：干姜8-16份、橘叶8-16份、车前子8-16份、鸡内金8-16份、白花蛇舌草6-10份、连钱草6-10份、决明子20-30份、柳枝20-30份、绿豆50-80份、甘草8-12份。本发明中药治疗胆囊炎，使用方法简便易行，药源丰富，价廉效高，消除症状较快，服药后未发现明显的不良反应。
Description
技术领域
本发明属于中医药技术领域，具体而言，涉及一种治疗慢性胆囊炎的药物组合物。
背景技术
慢性胆囊炎在临床上属常见及多发病，且病释长，轻重不一，常反复发作，属中医学的“胁痛”、“肝胃气痛” 之范畴。其病因多由饮食不节、情志不遂导致肝络失和。其病位在胆，但与肝和脾胃有关。肝郁乘土、脾气不足致肝郁脾虚；肝郁日久、气机紊乱，脏腑失和则瘀阻胆络或湿热内蕴，或正虚邪恋，而致本病缠绵难愈反复发作。
在临床工作中，本病以饮食不节，情志不遂而导致的最为多见。现代社会，工作和生活压力大，生活条件较好，竞争比较激烈，人们的精神、生活欲望比较高，但又不能事事随人所愿，一旦有不尽人意易出现情志不和，精神抑郁，久则肝郁气滞，又伤脾胃。多表现为虚实央杂之证，郁、瘀、湿、热、虚并见。
发明内容
本发明的目的在于提供一种治疗慢性胆囊炎的药物组合物，该药经内服后可使胆道通畅，胆汁稀释而易于排出，从而消除胆囊炎症，疗效显著。
本发明的目的是这样实现的：
一种治疗慢性胆囊炎的药物组合物，由如下重量份的中药材原料制备而成：干姜8-16份、橘叶8-16份、车前子8-16份、鸡内金8-16份、白花蛇舌草6-10份、连钱草6-10份、决明子20-30份、柳枝20-30份、绿豆50-80份、甘草8-12份。
优选地，上述治疗慢性胆囊炎的药物组合物，由如下重量份的中药材原料制备而成：干姜10-13份、橘叶10-13份、车前子10-13份、鸡内金10-13份、白花蛇舌草8-10份、连钱草8-10份、决明子23-27份、柳枝23-27份、绿豆60-70份、甘草9-11份。
进一步优选地，上述治疗慢性胆囊炎的药物组合物，由如下重量份的中药材原料制备而成：干姜12份、橘叶12份、车前子12份、鸡内金12份、白花蛇舌草9份、连钱草9份、决明子25份、柳枝25份、绿豆65份、甘草10份。
进一步优选地，本发明所述治疗慢性胆囊炎的药物组合物，它为口服制剂，包括口服液、颗粒剂、片剂、胶囊；优选所述的口服制剂为口服液和颗粒剂。
本发明涉及的中药口服液的制备方法包括如下步骤：
（1）取处方量的上述中药材原料，洗净去杂，晾干，混合，粉碎成大颗粒；
（2）再将上述颗粒状药材加水漫过药面2cm，浸泡1-1.2h，捞出药材置多功能提取灌中加水煎煮2次，第一次加总药材8-12倍量的水，煎煮2h，取煎液，滤过，第二次加总药材8-10倍量的水，煎煮1.5h，取两次煎液合并，滤过，浓缩至90℃时相对密度为1.25的浓缩液；
（3）将浓缩液置0-5℃低温冷藏24h，将冷藏液加0.3%的助滤剂硅藻土，滤过，滤液再浓缩至每毫升含4-5g生药量，搅拌均匀，置0-5℃低温冷藏24h，将冷藏液滤过，得口服液。
用法用量：患者每日服用60ml，早晚各一次。
根据中医药史料记载，上述五味中药材原料的药理活性如下：
干姜：温中散寒，回阳通脉，燥湿消痰，温肺化饮。主治脘腹冷痛；呕吐；泄泻，亡阳厥逆；寒饮喘咳；寒湿痹痛。选用姜科植物姜Zingiber officinale Rosc.的干燥根茎。
橘叶：疏肝，行气，化痰，消肿毒。治胁痛，乳痈，肺痈，咳嗽，胸膈痞满，疝气。选用芸香科植物橘 Citrus reticulata Blanco的叶或朱橘等多种橘类的叶。
车前子：清热利尿；渗湿止泻；明目；祛痰。主治：主小便不利；淋浊带下；水肿胀满；暑湿泻痢；目赤障翳；痰热咳喘。选用为车前科植物车前大车前及平车前的种子。
鸡内金：消食健胃助消化，涩精止遗。可以促进胃液分泌，提高胃酸度及消化力，使胃运动功能明显增强，胃排空加快。选用雉科动物家鸡 Gallus gallus domesticus Brisson 的干燥沙囊内壁。
白花蛇舌草：拉丁名Herba Hedyotis Diffusae，具有清热解毒、利湿的作用；主治：肺热喘咳；咽喉肿痛；肠痈；疖肿疮疡；毒蛇咬伤；热淋涩痛；水肿；痢疾；肠炎；湿热黄疸；癌肿。选自茜草科植物白花蛇舌草 Hedyotis diffusa Willd. 的干燥全草。
连钱草：利湿通淋，清热解毒，散瘀消肿。用于热淋，石淋，湿热黄疸，疮痈肿痛，跌扑损伤。选自为唇形科多年生草本植物活血丹(Glechomalongituba(Nakai)Kupr.)的干燥地上部分。
决明子：清热明目，润肠通。用于目赤涩痛，羞明多泪，头痛眩晕，目暗不明，大便秘结。选用豆科一年生草本植物决明或小决明的干燥成熟种子。
柳枝：祛风，利尿，止痛，消肿。治风湿痹痛，淋病，白浊，小便不通，传染性肝炎，风肿，疔疮，丹毒，齿龋，龈肿。选用杨柳科植物垂柳的干燥枝条。
绿豆：清热；消暑；利水；解毒。暑热烦渴；感冒发热；霍乱吐泻；痰热哮喘；头痛目赤；口舌生疮；水肿尿少；疮疡痈肿；风疹丹毒；药物及食物中毒。选用豆科植物绿豆的种子。
甘草：补脾益气，清热解毒，祛痰止咳，缓急止痛，调和诸药。用于脾胃虚弱，倦怠乏力，心悸气短，咳嗽痰多，脘腹、四肢挛急疼痛，痈肿疮毒，缓解药物毒性、烈性。选用为双子叶植物豆科 Leguminosae甘草 Glycyrrhiza uralensis Fisch.，胀果甘草 G. inflata Bat.，或光果甘草 G. glabra L. 的根及根茎。
本发明中药治疗胆囊炎，使用方法简便易行，药源丰富，价廉效高，消除症状较快，服药后未发现明显的不良反应，因而在乡村医院很适合使用。
具体实施方式
以下是本发明的具体实施例，对本发明的技术方案做进一步作描述，但是本发明的保护范围并不限于这些实施例。凡是不背离本发明构思的改变或等同替代均包括在本发明的保护范围之内。
实施例1中药口服液的制备
生药处方：干姜120克、橘叶120克、车前子120克、鸡内金120克、白花蛇舌草90克、连钱草90克、决明子250克、柳枝250克、绿豆650克、甘草100克。
口服液制备方法：
（1）取处方量的上述中药材原料，洗净去杂，晾干，混合，粉碎成大颗粒；
（2）再将上述颗粒状药材加水漫过药面2cm，浸泡1-1.2h，捞出药材置多功能提取灌中加水煎煮2次，第一次加总药材10倍量的水，煎煮2h，取煎液，滤过，第二次加总药材8倍量的水，煎煮1.5h，取两次煎液合并，滤过，浓缩至90℃时相对密度为1.25的浓缩液；
（3）将浓缩液置0-5℃低温冷藏24h，将冷藏液加0.3%的助滤剂硅藻土，滤过，滤液再浓缩至每毫升含4.5g生药量，搅拌均匀，置0-5℃低温冷藏24h，将冷藏液滤过，得口服液。
实施例2 中药口服液的制备
生药处方：干姜160克、橘叶100克、车前子80克、鸡内金100克、白花蛇舌草100克、连钱草60克、决明子200克、柳枝300克、绿豆740克、甘草120克。
口服液制备方法：
（1）取处方量的上述中药材原料，洗净去杂，晾干，混合，粉碎成大颗粒；
（2）再将上述颗粒状药材加水漫过药面2cm，浸泡1-1.2h，捞出药材置多功能提取灌中加水煎煮2次，第一次加总药材10倍量的水，煎煮2h，取煎液，滤过，第二次加总药材10倍量的水，煎煮1.5h，取两次煎液合并，滤过，浓缩至90℃时相对密度为1.25的浓缩液；
（3）将浓缩液置0-5℃低温冷藏24h，将冷藏液加0.3%的助滤剂硅藻土，滤过，滤液再浓缩至每毫升含5g生药量，搅拌均匀，置0-5℃低温冷藏24h，将冷藏液滤过，得口服液。
实施例3 中药口服液的制备
生药处方：干姜80克、橘叶160克、车前子160克、鸡内金160克、白花蛇舌草60克、连钱草100克、决明子250克、柳枝230克、绿豆500克、甘草80克。
口服液制备方法：
（1）取处方量的上述中药材原料，洗净去杂，晾干，混合，粉碎成大颗粒；
（2）再将上述颗粒状药材加水漫过药面2cm，浸泡1-1.2h，捞出药材置多功能提取灌中加水煎煮2次，第一次加总药材10倍量的水，煎煮2h，取煎液，滤过，第二次加总药材8倍量的水，煎煮1.5h，取两次煎液合并，滤过，浓缩至90℃时相对密度为1.25的浓缩液；
（3）将浓缩液置0-5℃低温冷藏24h，将冷藏液加0.3%的助滤剂硅藻土，滤过，滤液再浓缩至每毫升含4-5g生药量，搅拌均匀，置0-5℃低温冷藏24h，将冷藏液滤过，得口服液。
实施例4 本发明的中药组合物对慢性胆囊炎患者的影响
按如下诊断标准确诊慢性胆囊炎患者：症见反复发作的上腹部疼痛，腹痛多发生于右上腹的胁肋部或中上腹或走窜不定，或时轻时重，痛甚者引肩背部痛，右上腹局部有压痛，疼痛多与饮食和情绪有关，发作期间伴有腹胀、纳差、嗳气、呃逆、口苦、厌食油腻等胃肠道症状，舌质稍红，苔白腻或稍黄、脉弦。B超检查：胆囊壁增厚，胆囊结石或胆囊缩小或变形，胆囊收缩功能差。患者共32例，男10例，女22例；年龄最大者74岁，最小者23岁，平均年龄37.5岁；病程最长16年，最短6个月，平均3.8年。
所有患者确诊后开始服用中药口服液（按本发明实施例1的处方工艺制备而成），每天于早餐后lh及晚餐后1h各服用30mL。2周为1个疗程。病程较长且病情较重者间隔1周后继服第2个疗程。服药期间：饮食规律以清淡为主， 忌辛辣刺激油腻食物，忌烟酒，避免情志刺激，随访半年。
疗效判断标准如下：
治愈：症状和体征完全消失，B超检查结果正常。
好转：症状和体征均减轻，B超检查结果有明显改善。
无效：症状、体征、B超检查均无明显改善。
试验结束后，32例患者治愈24例，随访半年无复发。好转7例，无效1例，治愈率75.0％ ，有效率96.9％。
典型病例：张某，男，31岁，2008年7月31日初诊。6个月前因饮酒和食油腻食物出现上腹部隐痛、阵发性加剧，恶心，在当地医院诊断为“急性胃肠炎”，给予阿托品、多酶片、乳酶生、黄连素、藿香正气水等治疗，病情无明显好转。后去某县医院检查诊断为“急性胆囊炎”，用中、西药治疗10余天有好转，但未治愈。精神萎靡，上腹部剑突下偏右处持续性隐痛，加剧时似刀割样，并向右肩胛下区放射，遇饮酒、食油腻食物即可加剧，恶心呕吐，有时呕吐黄苦水，嗳气吞酸，大便秘结难解，舌质红苔黄腻，脉弦数。查体温37.4℃，脉搏98次/min，呼吸频率19次/min，血压13.6/10.7kPa。巩膜轻度黄染，心肺无异常，上腹部腹直肌外缘与肋弓缘交界处压痛，莫非氏征阳性，肝脾肋下未触及。化验白细胞12.6×109/L、中性粒细胞0.81、淋巴细胞0.19、血红蛋白l20g/L。B超提示胆囊壁增厚，轮廓欠清晰。诊断为慢性胆囊炎。采用如下方剂治疗：干姜12克、橘叶12克、车前子12克、鸡内金12克、白花蛇舌草9克、连钱草9克、决明子25克、柳枝25克、绿豆65克、甘草10克。中药材浸润后加水600mL，煎至400mL，每日2次，每次服200mL，1日1剂。服4剂后精神好转，上腹疼痛减轻，恶心呕吐消失，食欲增加，大便已解且软。服8剂而愈，至今未再复发。
Claims (5)
1.一种治疗慢性胆囊炎的药物组合物，其特征在于：由如下重量份的中药材原料制备而成：干姜8-16份、橘叶8-16份、车前子8-16份、鸡内金8-16份、白花蛇舌草6-10份、连钱草6-10份、决明子20-30份、柳枝20-30份、绿豆50-80份、甘草8-12份。
2.根据权利要求1所述的治疗慢性胆囊炎的药物组合物，其特征在于：由如下重量份的中药材原料制备而成：干姜10-13份、橘叶10-13份、车前子10-13份、鸡内金10-13份、白花蛇舌草8-10份、连钱草8-10份、决明子23-27份、柳枝23-27份、绿豆60-70份、甘草9-11份。
3.根据权利要求2所述的治疗慢性胆囊炎的药物组合物，其特征在于：由如下重量份的中药材原料制备而成：干姜12份、橘叶12份、车前子12份、鸡内金12份、白花蛇舌草9份、连钱草9份、决明子25份、柳枝25份、绿豆65份、甘草10份。
4.根据权利要求1或2或3所述的治疗慢性胆囊炎的药物组合物，其特征在于：所述的药物组合物为口服制剂；所述的口服制剂包括口服液、颗粒剂、片剂、胶囊。
5.根据权利要求4所述的治疗慢性胆囊炎的药物组合物，其特征在于：所述的口服制剂为口服液和颗粒剂。
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