CN103405546B - Preparation method of traditional Chinese medicine ointment - Google Patents
Preparation method of traditional Chinese medicine ointment Download PDFInfo
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- 238000002360 preparation method Methods 0.000 title claims abstract description 35
- 239000002674 ointment Substances 0.000 title claims abstract description 32
- 239000003814 drug Substances 0.000 title claims abstract description 17
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 72
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 66
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 55
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims abstract description 25
- 239000007788 liquid Substances 0.000 claims abstract description 19
- 239000000203 mixture Substances 0.000 claims abstract description 15
- 238000000605 extraction Methods 0.000 claims abstract description 14
- 239000006071 cream Substances 0.000 claims abstract description 11
- 238000010992 reflux Methods 0.000 claims abstract description 9
- 239000008213 purified water Substances 0.000 claims description 23
- 238000003756 stirring Methods 0.000 claims description 22
- 235000019640 taste Nutrition 0.000 claims description 18
- 238000007873 sieving Methods 0.000 claims description 14
- 230000001804 emulsifying effect Effects 0.000 claims description 10
- -1 Polyethylene Polymers 0.000 claims description 9
- 239000004698 Polyethylene Substances 0.000 claims description 8
- 235000021355 Stearic acid Nutrition 0.000 claims description 8
- 229960001617 ethyl hydroxybenzoate Drugs 0.000 claims description 8
- 235000010228 ethyl p-hydroxybenzoate Nutrition 0.000 claims description 8
- 239000004403 ethyl p-hydroxybenzoate Substances 0.000 claims description 8
- NUVBSKCKDOMJSU-UHFFFAOYSA-N ethylparaben Chemical compound CCOC(=O)C1=CC=C(O)C=C1 NUVBSKCKDOMJSU-UHFFFAOYSA-N 0.000 claims description 8
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 claims description 8
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims description 8
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims description 8
- 229920000573 polyethylene Polymers 0.000 claims description 8
- 239000008117 stearic acid Substances 0.000 claims description 8
- 241000903946 Clematidis Species 0.000 claims description 7
- 238000009835 boiling Methods 0.000 claims description 7
- 238000001816 cooling Methods 0.000 claims description 7
- AMTWCFIAVKBGOD-UHFFFAOYSA-N dioxosilane;methoxy-dimethyl-trimethylsilyloxysilane Chemical compound O=[Si]=O.CO[Si](C)(C)O[Si](C)(C)C AMTWCFIAVKBGOD-UHFFFAOYSA-N 0.000 claims description 7
- 229940079593 drug Drugs 0.000 claims description 7
- 238000001914 filtration Methods 0.000 claims description 7
- 239000002994 raw material Substances 0.000 claims description 7
- 210000000582 semen Anatomy 0.000 claims description 7
- 229940083037 simethicone Drugs 0.000 claims description 7
- 241000555682 Forsythia x intermedia Species 0.000 claims description 2
- 241000545442 Radix Species 0.000 claims description 2
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 claims 1
- 241000951473 Schizonepeta Species 0.000 claims 1
- 238000000034 method Methods 0.000 abstract description 12
- 238000002156 mixing Methods 0.000 abstract description 9
- 239000000463 material Substances 0.000 abstract description 4
- 239000007787 solid Substances 0.000 abstract description 4
- 238000004945 emulsification Methods 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 230000009286 beneficial effect Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 238000002844 melting Methods 0.000 abstract 1
- 230000008018 melting Effects 0.000 abstract 1
- 239000000047 product Substances 0.000 description 13
- 239000004615 ingredient Substances 0.000 description 8
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 7
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 6
- AXTGDCSMTYGJND-UHFFFAOYSA-N 1-dodecylazepan-2-one Chemical compound CCCCCCCCCCCCN1CCCCCC1=O AXTGDCSMTYGJND-UHFFFAOYSA-N 0.000 description 6
- LQGUBLBATBMXHT-UHFFFAOYSA-N chrysophanol Chemical compound C1=CC=C2C(=O)C3=CC(C)=CC(O)=C3C(=O)C2=C1O LQGUBLBATBMXHT-UHFFFAOYSA-N 0.000 description 6
- 229910001220 stainless steel Inorganic materials 0.000 description 5
- 239000010935 stainless steel Substances 0.000 description 5
- 229930003427 Vitamin E Natural products 0.000 description 3
- FPVRUILUEYSIMD-RPRRAYFGSA-N [(8s,9r,10s,11s,13s,14s,16r,17r)-9-fluoro-11-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] acetate Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(OC(C)=O)[C@@]1(C)C[C@@H]2O FPVRUILUEYSIMD-RPRRAYFGSA-N 0.000 description 3
- 229960003657 dexamethasone acetate Drugs 0.000 description 3
- 150000002148 esters Chemical class 0.000 description 3
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 3
- 229940046009 vitamin E Drugs 0.000 description 3
- 235000019165 vitamin E Nutrition 0.000 description 3
- 239000011709 vitamin E Substances 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 2
- 241000238370 Sepia Species 0.000 description 1
- 229940087511 calcium disodium versenate Drugs 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000001647 drug administration Methods 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 238000004064 recycling Methods 0.000 description 1
- 229920002545 silicone oil Polymers 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
Abstract
The invention discloses a preparation method of a traditional Chinese medicine ointment. The preparation method is characterized by comprising the following steps: carrying out ethanol reflux extraction on eight herbal pieces, concentrating into clear cream of which the relative density is 1.00-1.05; separately heating and melting on an oil phase; firstly, dissolving glycerol into water; mixing the clear cream with a water phase and then mixing with the glycerol; adding triethanolamine to a water-phase pot; and controlling the emulsification temperature at 68-72 DEG C. The preparation method has the beneficial effects that the glycerol is in a liquid state, so that the condition that the water phase is evenly mixed with water can be ensured by mixing with water in advance; the clear cream and other water-phase materials in a solid state or semi-solid state are heated to boil; the clear cream and other water-phase materials can be completely melted and fully mixed, so that the emulsification effect of the next step is ensured. The triethanolamine is independently watered and mixed; the reaction of the triethanolamine and parietic acid in the clear cream is avoided; the mixture can be rapidly emulsified after the triethanolamine is added, so that the ointment prepared by the method is not only light in color (faint yellow to yellowish-brown), but also exquisite, and has glossiness, proper thin consistency and better skin adhesion.
Description
Technical field
The preparation method that the present invention relates to a kind of Chinese medicine ointment, belongs to field of pharmaceutical preparations.
Background technology
Reply (99) capital is defended medicine system and is examined in No. 326 certification of word, has provided happy white prescription and the preparation method of Chinese medicine ointment skin:
Method for making: above ten tastes, except vitamin E, dexamethasone acetate, all the other eight tastes add 70% alcohol reflux secondary, 2 hours for the first time, 1 hour for the second time, merge alcohol liquid, filter, filtrate recycling ethanol is extremely without alcohol taste, add vitamin E, dexamethasone acetate, mix, be cooled to 75 ℃, standby; Separately get glycerol 80g, Polyethylene glycol-2000 16g, hexadecanol 56g, stearic acid 80g, silicone oil 80g, azone 30g, triethanolamine 30g, ethylparaben 1g, Calcium Disodium Versenate 1g, mix, heat fused, be cooled to 75 ℃, add in the medicinal liquid of above-mentioned equal temperature, stir, be cooled to room temperature, obtain.
On August 6th, 2009, when Beijing Drug Administration changes medical institutions' preparation authentication code (batch piece number: mend 09098) for this medicine, following suggestions made after examination and conclusion have been provided: delete dexamethasone acetate and vitamin E in this preparation prescription, in method for making, delete corresponding contents, other techniques are constant.
Former certification and change the preparation method after authentication code, due to each step and technological parameter too wide in range, specific operation process is clear and definite not, poor operability is difficult to guarantee the stability of product quality, the fluctuation of product quality attribute is larger.Meanwhile, adopt the prescription of aforementioned record and method for making to prepare the happy frost of ointment skin, the character of resulting product is not good enough, and concrete manifestation is as follows:
1. ointment is partially rare, and the tack of use procedure on skin is not good, does not reach due therapeutic effect;
2. ointment is fine and smooth not, lacks glossiness, and color is dark (sepia) partially, and product characteristics overall look and feel are not good enough.
Summary of the invention
For solving the deficiencies in the prior art, the object of the present invention is to provide a kind of new method of preparing Chinese medicine ointment, the Chinese medicine ointment of being prepared by the method not only denseness increases, and the character such as fine and smooth degree, glossiness, color all improves.
In order to realize above-mentioned target, the present invention adopts following technical scheme:
The preparation method that skin is happy white, is characterized in that, comprises the following steps:
One, the extraction of clear paste is concentrated:
(1), take 3 parts of Herba Schizonepetae 15 parts of (weight), 12 parts of Fructus Forsythiaes, 15 parts of the Radixs Angelicae Dahuricae, 9 parts of Rhizoma Atractylodis, 12 parts of Radix Clematidiss, 9 parts of Radix Et Rhizoma Rhei, 30 parts of Semen Hydnocarpis, Cortex Dictamni and amount to the eight taste prepared slices of Chinese crude drugs, add 70% alcohol reflux twice, for the first time timing 2h after ebuillition of heated; Timing 1h after ebuillition of heated for the second time, twice backflow merges, stand-by;
(2), backflow alcohol extraction medicinal liquid is transferred in backflow concentration tank and is evaporated to without alcohol taste, then continuing to be concentrated into the relative density of gained clear paste in the time of 50 ℃ is 0.98-1.07;
Two, the preparation of ointment:
(1), 80 parts of 80 parts of simethicone, 30 parts of azones, 56 parts of hexadecanol, stearic acid are put in oil phase pot, be heated to dissolve completely;
(2), sieve after 80 parts of glycerol are mixed with 125 parts of purified water and suck in main cooker;
(3), clear paste is placed in water pot, add 1 part of ethylparaben, 1 part of disodiumedetate, 16 parts and 125 parts purified water of Polyethylene glycol-2000, be heated to boiling, after sieving while hot, suck in main cooker and mix with glycerol, main kettle temperature remains on 65 ℃-75 ℃;
(4), in water pot, add 30 parts of triethanolamine and 150 parts of purified water, then heat medicinal liquid, and suck in main cooker after sieving while hot;
Three, emulsifying, go out cream:
(1), the raw material in oil phase pot is at the uniform velocity sucked in main cooker after filtering, suck immediately and stir;
(2), stir and to stop, cooling main cooker, obtains the happy white ointment of skin.
The preparation method that aforesaid skin is happy white, is characterized in that, in the extraction concentration step of clear paste, the relative density of gained clear paste in the time of 50 ℃ is 1.00-1.05.
The preparation method that aforesaid skin is happy white, is characterized in that, in the preparation steps of ointment, the temperature in main cooker remains on 68 ℃-72 ℃.
The preparation method that aforesaid skin is happy white, is characterized in that, in the preparation steps of ointment, the temperature in oil phase pot remains on 68 ℃-72 ℃.
The preparation method that aforesaid skin is happy white, is characterized in that, in the preparation steps of ointment, the heating-up temperature of triethanolamine remains on 68 ℃-72 ℃.
The preparation method that aforesaid skin is happy white, is characterized in that, in softening, go out cream step, the time that oil phase is all transferred to main cooker is controlled in 5min.
The preparation method that aforesaid skin is happy white, is characterized in that, in softening, go out cream step, the speed of stirring is 2500-2800rpm.
The preparation method that aforesaid skin is happy white, is characterized in that, in the extraction concentration step of clear paste, the amount that adds for the first time 70% ethanol is 10 times of decoction pieces volume, and the amount that adds for the second time 70% ethanol is 8 times of medicinal residues volume.
Usefulness of the present invention is: first glycerol is mixed with purified water, because glycerol is liquid, mix and can guarantee that water is mixed homogeneously with water below in advance with water; Clear paste and solid-state or semi-solid other water materials are heated to boil, and can make fusing each other mix completely and fully, and then guarantee next step emulsifying effectiveness; Triethanolamine adds separately water and mixes, avoided one of effective ingredient in triethanolamine and clear paste chrysophanic acid to react, low temperature salify, high temperature becomes ester, therefore add separately triethanolamine can effectively protect the effective ingredient in clear paste, and add emulsifying rapidly after triethanolamine; The ointment being made by method of the present invention, it is color more shallow (being faint yellow to yellowish-brown) not only, and fine and smooth, and with glossiness, rare denseness is moderate, and skin attachment is better.
Accompanying drawing explanation
Fig. 1 is the flow chart of the preparation method of Chinese medicine ointment of the present invention.
The specific embodiment
Below in conjunction with Fig. 1 and specific embodiment, the present invention is done to concrete introduction.
Embodiment 1
(1), take Herba Schizonepetae 15g, Fructus Forsythiae 12g, Radix Angelicae Dahuricae 15g, Rhizoma Atractylodis 9g, Radix Clematidis 12g, Radix Et Rhizoma Rhei 9g, Semen Hydnocarpi 30g, the Cortex Dictamni 3g eight taste prepared slices of Chinese crude drugs altogether, add twice of 70% ethanol (adopting ethanol densimeter to measure) reflux, extract,, the amount that adds for the first time 70% ethanol is 10 times of decoction pieces volume, then timing 2h after ebuillition of heated; The amount that adds for the second time 70% ethanol is 8 times of medicinal residues volume, timing 1h after ebuillition of heated then, and twice backflow crossed respectively 80 mesh sieves, then in stainless steel cask, merges, and adds a cover storage, stand-by.
(2), backflow alcohol extraction medicinal liquid is transferred in backflow concentration tank and is evaporated to without alcohol taste, then continuing to be concentrated into the relative density of gained clear paste in the time of 50 ℃ is 1.00-1.02.
(3), simethicone 80g, azone 30g, hexadecanol 56g, stearic acid 80g are put in oil phase pot, stir and heat oil phase to 65 ℃, making it to dissolve completely.
(4), sieve after glycerol 80g is mixed with 125g purified water and suck in main cooker.
(5), clear paste is placed in water pot, add ethylparaben 1g, disodiumedetate 1g, Polyethylene glycol-2000 16g and 125g purified water, be heated to boiling, after sieving while hot, suck in main cooker and mix with glycerol, main kettle temperature remains on 65 ℃.
(6), in water pot, add triethanolamine 30g and 150g purified water, then heat medicinal liquid to 65 ℃, and suck in main cooker after sieving while hot.
(7), when oil phase pot and main cooker temperature are during all at 65 ℃, the raw material in oil phase pot is at the uniform velocity sucked in main cooker after filtering, the time that oil phase is all transferred to main cooker is controlled in 5min, rapid stirring immediately after suction, mixing speed is decided to be 2500rpm.
(8), stir and to stop, cooling main cooker, obtains the happy white ointment of skin.
Products obtained therefrom character: be faint yellow, exquisiteness, with glossiness, rare denseness is partially rare, and skin attachment is general.
Embodiment 2
(1), take Herba Schizonepetae 15g, Fructus Forsythiae 12g, Radix Angelicae Dahuricae 15g, Rhizoma Atractylodis 9g, Radix Clematidis 12g, Radix Et Rhizoma Rhei 9g, Semen Hydnocarpi 30g, the Cortex Dictamni 3g eight taste prepared slices of Chinese crude drugs altogether, add twice of 70% ethanol (adopting ethanol densimeter to measure) reflux, extract,, the amount that adds for the first time 70% ethanol is 10 times of decoction pieces volume, then timing 2h after ebuillition of heated; The amount that adds for the second time 70% ethanol is 8 times of medicinal residues volume, timing 1h after ebuillition of heated then, and twice backflow crossed respectively 80 mesh sieves, then in stainless steel cask, merges, and adds a cover storage, stand-by.
(2), backflow alcohol extraction medicinal liquid is transferred in backflow concentration tank and is evaporated to without alcohol taste, then continuing to be concentrated into the relative density of gained clear paste in the time of 50 ℃ is 1.00-1.02.
(3), simethicone 80g, azone 30g, hexadecanol 56g, stearic acid 80g are put in oil phase pot, stir and heat oil phase to 68 ℃, making it to dissolve completely.
(4), sieve after glycerol 80g is mixed with 125g purified water and suck in main cooker.
(5), clear paste is placed in water pot, add ethylparaben 1g, disodiumedetate 1g, Polyethylene glycol-2000 16g and 125g purified water, be heated to boiling, after sieving while hot, suck in main cooker and mix with glycerol, main kettle temperature remains on 68 ℃.
(6), in water pot, add triethanolamine 30g and 150g purified water, then heat medicinal liquid to 68 ℃, and suck in main cooker after sieving while hot.
(7), when oil phase pot and main cooker temperature are during all at 68 ℃, the raw material in oil phase pot is at the uniform velocity sucked in main cooker after filtering, the time that oil phase is all transferred to main cooker is controlled in 5min, rapid stirring immediately after suction, mixing speed is decided to be 2600rpm.
(8), stir and to stop, cooling main cooker, obtains the happy white ointment of skin.
Products obtained therefrom character: be faint yellow to yellowish-brown, exquisiteness, with glossiness, rare denseness is moderate, and skin attachment is good.
Embodiment 3
(1), take Herba Schizonepetae 15g, Fructus Forsythiae 12g, Radix Angelicae Dahuricae 15g, Rhizoma Atractylodis 9g, Radix Clematidis 12g, Radix Et Rhizoma Rhei 9g, Semen Hydnocarpi 30g, the Cortex Dictamni 3g eight taste prepared slices of Chinese crude drugs altogether, add twice of 70% ethanol (adopting ethanol densimeter to measure) reflux, extract,, the amount that adds for the first time 70% ethanol is 10 times of decoction pieces volume, then timing 2h after ebuillition of heated; The amount that adds for the second time 70% ethanol is 8 times of medicinal residues volume, timing 1h after ebuillition of heated then, and twice backflow crossed respectively 80 mesh sieves, then in stainless steel cask, merges, and adds a cover storage, stand-by.
(2), backflow alcohol extraction medicinal liquid is transferred in backflow concentration tank and is evaporated to without alcohol taste, then continuing to be concentrated into the relative density of gained clear paste in the time of 50 ℃ is 1.00-1.02.
(3), simethicone 80g, azone 30g, hexadecanol 56g, stearic acid 80g are put in oil phase pot, stir and heat oil phase to 70 ℃, making it to dissolve completely.
(4), sieve after glycerol 80g is mixed with 125g purified water and suck in main cooker.
(5), clear paste is placed in water pot, add ethylparaben 1g, disodiumedetate 1g, Polyethylene glycol-2000 16g and 125g purified water, be heated to boiling, after sieving while hot, suck in main cooker and mix with glycerol, main kettle temperature remains on 70 ℃.
(6), in water pot, add triethanolamine 30g and 150g purified water, then heat medicinal liquid to 70 ℃, and suck in main cooker after sieving while hot.
(7), when oil phase pot and main cooker temperature are during all at 70 ℃, the raw material in oil phase pot is at the uniform velocity sucked in main cooker after filtering, the time that oil phase is all transferred to main cooker is controlled in 5min, rapid stirring immediately after suction, mixing speed is decided to be 2700rpm.
(8), stir and to stop, cooling main cooker, obtains the happy white ointment of skin.
Products obtained therefrom character: be faint yellow to yellowish-brown, exquisiteness, with glossiness, rare denseness is moderate, and skin attachment is good.
Embodiment 4
(1), take Herba Schizonepetae 15g, Fructus Forsythiae 12g, Radix Angelicae Dahuricae 15g, Rhizoma Atractylodis 9g, Radix Clematidis 12g, Radix Et Rhizoma Rhei 9g, Semen Hydnocarpi 30g, the Cortex Dictamni 3g eight taste prepared slices of Chinese crude drugs altogether, add twice of 70% ethanol (adopting ethanol densimeter to measure) reflux, extract,, the amount that adds for the first time 70% ethanol is 10 times of decoction pieces volume, then timing 2h after ebuillition of heated; The amount that adds for the second time 70% ethanol is 8 times of medicinal residues volume, timing 1h after ebuillition of heated then, and twice backflow crossed respectively 80 mesh sieves, then in stainless steel cask, merges, and adds a cover storage, stand-by.
(2), backflow alcohol extraction medicinal liquid is transferred in backflow concentration tank and is evaporated to without alcohol taste, then continuing to be concentrated into the relative density of gained clear paste in the time of 50 ℃ is 1.00-1.02.
(3), simethicone 80g, azone 30g, hexadecanol 56g, stearic acid 80g are put in oil phase pot, stir and heat oil phase to 72 ℃, making it to dissolve completely.
(4), sieve after glycerol 80g is mixed with 125g purified water and suck in main cooker.
(5), clear paste is placed in water pot, add ethylparaben 1g, disodiumedetate 1g, Polyethylene glycol-2000 16g and 125g purified water, be heated to boiling, after sieving while hot, suck in main cooker and mix with glycerol, main kettle temperature remains on 72 ℃.
(6), in water pot, add triethanolamine 30g and 150g purified water, then heat medicinal liquid to 72 ℃, and suck in main cooker after sieving while hot.
(7), when oil phase pot and main cooker temperature are during all at 72 ℃, the raw material in oil phase pot is at the uniform velocity sucked in main cooker after filtering, the time that oil phase is all transferred to main cooker is controlled in 5min, rapid stirring immediately after suction, mixing speed is decided to be 2800rpm.
(8), stir and to stop, cooling main cooker, obtains the happy white ointment of skin.
Products obtained therefrom character: be faint yellow to yellowish-brown, exquisiteness, with glossiness, rare denseness is moderate, and skin attachment is good.
Embodiment 5
(1), take Herba Schizonepetae 15g, Fructus Forsythiae 12g, Radix Angelicae Dahuricae 15g, Rhizoma Atractylodis 9g, Radix Clematidis 12g, Radix Et Rhizoma Rhei 9g, Semen Hydnocarpi 30g, the Cortex Dictamni 3g eight taste prepared slices of Chinese crude drugs altogether, add twice of 70% ethanol (adopting ethanol densimeter to measure) reflux, extract,, the amount that adds for the first time 70% ethanol is 10 times of decoction pieces volume, then timing 2h after ebuillition of heated; The amount that adds for the second time 70% ethanol is 8 times of medicinal residues volume, timing 1h after ebuillition of heated then, and twice backflow crossed respectively 80 mesh sieves, then in stainless steel cask, merges, and adds a cover storage, stand-by.
(2), backflow alcohol extraction medicinal liquid is transferred in backflow concentration tank and is evaporated to without alcohol taste, then continuing to be concentrated into the relative density of gained clear paste in the time of 50 ℃ is 1.00-1.02.
(3), simethicone 80g, azone 30g, hexadecanol 56g, stearic acid 80g are put in oil phase pot, stir and heat oil phase to 75 ℃, making it to dissolve completely.
(4), sieve after glycerol 80g is mixed with 125g purified water and suck in main cooker.
(5), clear paste is placed in water pot, add ethylparaben 1g, disodiumedetate 1g, Polyethylene glycol-2000 16g and 125g purified water, be heated to boiling, after sieving while hot, suck in main cooker and mix with glycerol, main kettle temperature remains on 75 ℃.
(6), in water pot, add triethanolamine 30g and 150g purified water, then heat medicinal liquid to 75 ℃, and suck in main cooker after sieving while hot.
(7), when oil phase pot and main cooker temperature are during all at 75 ℃, the raw material in oil phase pot is at the uniform velocity sucked in main cooker after filtering, the time that oil phase is all transferred to main cooker is controlled in 5min, rapid stirring immediately after suction, mixing speed is decided to be 2800rpm.
(8), stir and to stop, cooling main cooker, obtains the happy white ointment of skin.
Products obtained therefrom character: deep yellow brown, exquisiteness, with glossiness, rare denseness is slightly thick, and skin attachment is good.
In addition; through contrast test, find; water, oil phase, clear paste are adopted in differing order and are mixed; even if other steps, technological parameter be identical (emulsifying under 68 ℃ of-72 ℃ of conditions, the clear paste relative density during at 50 ℃ is 1.00 etc.) all; the degree that the character of gained ointment and effective ingredient obtain protection is all different, thereby the therapeutic effect of product is also different.Concrete relatively referring to table 1.
The impact of table 1 order by merging on product characteristics
In embodiment 9, because adding separately water, triethanolamine mixes, and avoided one of effective ingredient in triethanolamine and clear paste chrysophanic acid to react, low temperature salify, high temperature becomes ester, therefore add separately triethanolamine can effectively protect the effective ingredient in clear paste.
As can be seen here; the water, oil phase, the clear paste order by merging that adopt the present invention to provide mix; its color more shallow (being faint yellow to yellowish-brown) not only of prepared ointment; and fine and smooth; with glossiness, rare denseness is moderate, and skin attachment is better; the more important thing is, it is more complete that effective ingredient is protected.
In addition, the concentrated link of extraction at clear paste, is evaporated to without after alcohol taste, continues to concentrate until the relative density of clear paste in the time of 50 ℃, within the scope of 0.98-1.07, observed rare denseness of final ointment, and comparative result is in Table 2.
The impact of the relative density of table 2 clear paste on the rare denseness of product
| ? | Clear paste relative density | Rare denseness | Emulsifying temperature |
| Embodiment 10 | 0.98 | Partially rare | 68℃ |
| Embodiment 11 | 1.00 | Moderate | 68℃ |
| Embodiment 12 | 1.02 | Moderate | 68℃ |
| Embodiment 13 | 1.05 | Moderate | 68℃ |
| Embodiment 14 | 1.07 | Partially thick | 68℃ |
As can be seen here, the relative density of clear paste is at 1.00-1.05(50 ℃) time, rare denseness of gained final products is best.
Preparation method of the present invention compared with the existing methods, is characterized in:
1, first glycerol is mixed with purified water, because glycerol is liquid, mix and can guarantee that water is mixed homogeneously with water below with water in advance;
2, clear paste and solid-state or semi-solid other water materials are heated to boil, and can make fusing each other mix completely and fully, and then guarantee next step emulsifying effectiveness;
3, triethanolamine adds separately water mixing, avoided one of effective ingredient in triethanolamine and clear paste chrysophanic acid (the low temperature salify that reacts, high temperature becomes ester), thus add separately triethanolamine can effectively protect the effective ingredient in clear paste, and add emulsifying rapidly after triethanolamine;
4, the ointment being made by method of the present invention, it is color more shallow (being faint yellow to yellowish-brown) not only, and fine and smooth, and with glossiness, rare denseness is moderate, and skin attachment is better.
It should be noted that, above-described embodiment does not limit the present invention in any form, and all employings are equal to replaces or technical scheme that the mode of equivalent transformation obtains, all drops in protection scope of the present invention.
Claims (7)
1. the happy white preparation method of skin, is characterized in that, comprises the following steps:
One, the extraction of clear paste is concentrated:
(1), take by weight 3 parts of 15 parts of Herba Schizonepetaes, 12 parts of Fructus Forsythiaes, 15 parts of the Radixs Angelicae Dahuricae, 9 parts of Rhizoma Atractylodis, 12 parts of Radix Clematidiss, 9 parts of Radix Et Rhizoma Rhei, 30 parts of Semen Hydnocarpis, Cortex Dictamni and amount to the eight taste prepared slices of Chinese crude drugs, add 70% alcohol reflux twice, for the first time timing 2h after ebuillition of heated; Timing 1h after ebuillition of heated for the second time, twice backflow merges, stand-by;
(2), backflow alcohol extraction medicinal liquid is transferred in backflow concentration tank and is evaporated to without alcohol taste, then continuing to be concentrated into the relative density of gained clear paste in the time of 50 ℃ is 1.00-1.05;
Two, the preparation of ointment:
(1), 80 parts of 80 parts of simethicone, 30 parts of azones, 56 parts of hexadecanol, stearic acid are put in oil phase pot, be heated to dissolve completely;
(2), sieve after 80 parts of glycerol are mixed with 125 parts of purified water and suck in main cooker;
(3), clear paste is placed in water pot, add 1 part of ethylparaben, 1 part of disodiumedetate, 16 parts and 125 parts purified water of Polyethylene glycol-2000, be heated to boiling, after sieving while hot, suck in main cooker and mix with glycerol, main kettle temperature remains on 65 ℃-75 ℃;
(4), in water pot, add 30 parts of triethanolamine and 150 parts of purified water, then heat medicinal liquid, and suck in main cooker after sieving while hot;
Three, emulsifying, go out cream:
(1), the raw material in oil phase pot is at the uniform velocity sucked in main cooker after filtering, suck immediately and stir;
(2), stir and to stop, cooling main cooker, obtains the happy white ointment of skin.
2. the happy white preparation method of skin according to claim 1, is characterized in that, in the preparation steps of ointment, the temperature in main cooker remains on 68 ℃-72 ℃.
3. the happy white preparation method of skin according to claim 2, is characterized in that, in the preparation steps of ointment, the temperature in oil phase pot remains on 68 ℃-72 ℃.
4. the happy white preparation method of skin according to claim 2, is characterized in that, in the preparation steps of ointment, the heating-up temperature of triethanolamine remains on 68 ℃-72 ℃.
5. the happy white preparation method of skin according to claim 1, is characterized in that, in emulsifying, go out in cream step, the time that oil phase is all transferred to main cooker is controlled in 5min.
6. the happy white preparation method of skin according to claim 1, is characterized in that, in emulsifying, go out in cream step, the speed of stirring is 2500-2800rpm.
7. according to the happy white preparation method of the skin described in claim 1 to 6 any one, it is characterized in that, in the extraction concentration step of clear paste, the amount that adds for the first time 70% ethanol is 10 times of decoction pieces volume, and the amount that adds for the second time 70% ethanol is 8 times of medicinal residues volume.
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| CN109528960A (en) * | 2018-12-27 | 2019-03-29 | 钟炉琼 | A kind of Chinese medicine composition with anti-inflammatory anti-itch effect |
| CN113925902A (en) * | 2021-12-01 | 2022-01-14 | 北京守儿健康科技有限公司 | Radix sophorae flavescentis ointment for treating eczema and preparation method thereof |
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