CN103405235A - Multi-mode temperature control dynamic test device for blood oxygen differential pressure - Google Patents
Multi-mode temperature control dynamic test device for blood oxygen differential pressure Download PDFInfo
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- CN103405235A CN103405235A CN201310346461XA CN201310346461A CN103405235A CN 103405235 A CN103405235 A CN 103405235A CN 201310346461X A CN201310346461X A CN 201310346461XA CN 201310346461 A CN201310346461 A CN 201310346461A CN 103405235 A CN103405235 A CN 103405235A
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Abstract
The invention discloses a multi-mode temperature control dynamic test device for blood oxygen differential pressure. The device comprises a gas cylinder, a gas input calibration controller, a first filter box, a second filter box, a third filter box, a sample incubator, a blood oxygen dynamic densimeter, and a blood oxygen analyzer. The gas calibration controller is connected with the gas cylinder and sequentially connected with the first filter box, the second filter box, the third filter box and the sample incubator to form a water bath temperature control module. The first filter box is connected with the second filter box through a first pipe, and the second filter box and the third filter box are connected through a second pipe. The third filter box is connected with the sample incubator through a third pipe provided with a valve. The sample incubator is connected with the blood oxygen dynamic densimeter and the blood oxygen analyzer both connected with a computer controller. The sample incubator is connected with the first filter box to form a residual gas circulation system. The sample incubator is connected with the temperature controller. The multi-mode temperature control dynamic test device for blood oxygen differential pressure has the advantages that temperature rise is fast and opening and closing are intermittently alternate.
Description
Technical field
The invention belongs to the experimental provision field, be specifically related to a kind of multimode controlling temp type blood oxygen pressure kinetic test device.
Background technology
To learn feature most important for various functions and the metabolism of life entity for take oxygen and the oxygen release dynamic process medium power of body cell, tissue or organ.Therefore, explore body and take oxygen and learn basic law with oxygen release process medium power, from cell to Level of organization, take oxygen and oxygen release function and provide the infrastest data for the generation state of disease under physiology or pathology for furtheing investigate.When the tradition blood gas analysis was only considered resting state, the measurement result of blood sampling point, belonged to the measurement of a single point.Even the sound the simulated state after improving is the two body environment of calming the anger alternately, can investigate to a certain extent and take the dynamic process replaced in oxygen and oxygen release process, but can not simulate environment or more wide in range variations in temperature in body body temperature fully, just realize the simple switching link of controlling gaseous sources.Therefore for realizing that thoroughly the analog machine internal milieu is such as temperature environment, the present invention will make up the deficiency of similar research device in the past, developed the blood oxygen pressure detection kinetics charger that has real-time temperature control, realizes the pattern that sound state dividing potential drop opens and closes intermittently, replaces and continues, to realize possessing the dynamic blood oxygen pressure kinetic test experiment of complexity of temperature control.
Summary of the invention
The present invention is intended to overcome the deficiency that traditional blood gas analysis can only the resting state spot measurement, and the pure simulation sound of one-shot state binary states air pressure environment and do not consider the defect of body body temperature homeostasis, provide a kind of multimode controlling temp type blood oxygen pressure kinetic test device, with the advantage that realizes that multifunctional mode and real-time synchronization dynamic are caught data.
In order to solve the problems of the technologies described above, the invention provides following technical scheme:
Multimode controlling temp type blood oxygen pressure kinetic test device, comprise gas cylinder, gas input controller calibration, the first Rose Box, the second Rose Box, the 3rd Rose Box, the sample culturing case, blood oxygen dynamic density instrument and blood oxygen analysis instrument, described gas calibration controller is connected with three gas cylinders arranged side by side, described gas calibration controller connects the first Rose Box successively, the second Rose Box, the 3rd Rose Box and sample culturing case are assembled into the water-bath temperature control module, the sample culturing case and bag are wrapped in temperature controller, between described the first Rose Box and the second Rose Box, between the second Rose Box and the 3rd Rose Box, by being installed, valvular pipeline connects, described the 3rd Rose Box with the sample culturing case by being with valvular pipeline to be connected, described sample culturing case is connected with blood oxygen dynamic density instrument and blood oxygen analysis instrument, described blood oxygen dynamic density instrument and blood oxygen analysis instrument are connected to computer controller, described sample culturing case connects the first Rose Box by pipeline and forms the residual air blood circulation, the temperature controller that described sample culturing case is bathed by pipeline and circulating distilled water is connected.
Further, described sample culturing case is airtight sample culturing case.
Further, described computer controller and temperature controller are provided with data storage cell.
Further, between the first Rose Box, the second Rose Box, the 3rd Rose Box, on connecting pipe, the gas pressure sensor control valve is installed.
Further, in the first Rose Box, the second Rose Box, the 3rd Rose Box, be provided with horizontal positioned and filter filter paper.
Compared with prior art, the present invention has following beneficial effect:
(1) it is simple that this sample culturing case utilizes circulating distilled water bath enforcement temperature control, and cost is lower, is easy to dismounting, and programming rate is very fast.
(2) 3 step by step Rose Box coordinate detachable 0.22um to filter filter paper, can carry out thorough degerming to gas, aseptic with the gas in the sample cell that guarantees to pass into sealing, thereby reach take oxygen and oxygen release dynamic process research uninterruptedly or seriality.
(3) the style product that the pump into incubator of sealing can be realized balanced temperature field, and can realize wide in range temperature gradient field by the temperature of controlling water-bath.
The air pressure of the gas pressure sensor control valve of (4) 3 hoses that connect between Rose Box step by step in can management and control sample culturing case, open and close intermittently accurately to realize taking sound state dividing potential drop in oxygen and oxygen release process, alternately and the various pattern continued.
The accompanying drawing explanation
Fig. 1 is the structural representation of multimode controlling temp type blood oxygen pressure kinetic test device of the present invention.
The specific embodiment
Below in conjunction with accompanying drawing, the preferred embodiments of the present invention are described, should be appreciated that preferred embodiment described herein, only for description and interpretation the present invention, is not intended to limit the present invention.
As shown in Figure 1, multimode controlling temp type blood oxygen pressure kinetic test device, comprise gas cylinder 1, gas input controller calibration 2, the first Rose Box 3, the second Rose Box 4, the 3rd Rose Box 5, sample culturing case 6, blood oxygen dynamic density instrument 7 and blood oxygen analysis instrument 8, on gas calibration controller 2, be connected with three gas cylinders 1 arranged side by side, this gas calibration controller 2 connects successively the first Rose Box 3, the second Rose Box 4, the 3rd Rose Box 5 and sample culturing case 6 and is assembled into the water-bath temperature control module, and the sample culturing case is airtight sample culturing case.Sample culturing case 6 is wrapped in temperature controller 11, between the first Rose Box 1 and the second Rose Box 2, between the second Rose Box and the 3rd Rose Box 3, by being installed, valvular pipeline connects, described the 3rd Rose Box 5 with sample culturing case 6 by being with valvular pipeline to be connected, described sample cell 6 is connected with blood oxygen dynamic density instrument 7 and blood oxygen analysis instrument 8, blood oxygen dynamic density instrument 7 and blood oxygen analysis instrument 8 are connected to computer controller 9, sample cell 6 connects the first Rose Box 3 by pipeline and forms the residual air blood circulation, the temperature controller 11 that described sample culturing case 6 is bathed by pipeline and circulating distilled water is connected.Described computer controller 9 and temperature controller 11 are provided with data storage cell, and the data of real-time detection are stored.Between the first Rose Box, the second Rose Box, the 3rd Rose Box, on connecting pipe, the gas pressure sensor control valve is installed, in the first Rose Box, the second Rose Box, the 3rd Rose Box, be provided with horizontal positioned and filter filter paper, filter filter paper and be positioned at Rose Box height 1/2 place.Between the upper and lower two parts of Rose Box, fixed by 4 corner screws.
After gas input aligner, after three kinds of gases mix with certain proportion after calibration, be connected into successively the first Rose Box 3, the second Rose Box 4, the 3rd Rose Box 5 carries out the hybrid filtering degerming, sample cell is accepted very even 3 kinds of gases, but described blood oxygen dynamic density instrument and the blood oxygen analysis instrument Real-Time Monitoring of being controlled by computer controller realizes measuring the aerobic of biological sample, under the different oxygen proportions by subtraction of anoxia or anaerobism, take the dynamic change of oxygen and oxygen release process, described circulating distilled water bath apparatus 10 carrys out the temperature of accurate Quality control incubator by distillation water-bath circulation, reach temperature control, described residual air cycle cooling plating drum connects output channel by sample culturing case 6 and returns to Rose Box 1, carrying out gas circulates again.
The foregoing is only the explanation embodiments of the present invention; be not limited to the present invention, for a person skilled in the art, within the spirit and principles in the present invention all; any modification of doing, be equal to replacement, improvement etc., within protection scope of the present invention all should be included in.
Claims (5)
1. multimode controlling temp type blood oxygen pressure kinetic test device, comprise gas cylinder, gas input controller calibration, the first Rose Box, the second Rose Box, the 3rd Rose Box, the sample culturing case, blood oxygen dynamic density instrument and blood oxygen analysis instrument, it is characterized in that, described gas calibration controller is connected with three gas cylinders arranged side by side, described gas calibration controller connects the first Rose Box successively, the second Rose Box, the 3rd Rose Box and sample culturing case are assembled into the water-bath temperature control module, the sample culturing case and bag are wrapped in temperature controller, between described the first Rose Box and the second Rose Box, between the second Rose Box and the 3rd Rose Box, by being installed, valvular pipeline connects, described the 3rd Rose Box with the sample culturing case by being with valvular pipeline to be connected, described sample culturing case is connected with blood oxygen dynamic density instrument and blood oxygen analysis instrument, described blood oxygen dynamic density instrument and blood oxygen analysis instrument are connected to computer controller, described sample culturing case connects the first Rose Box by pipeline and forms the residual air blood circulation, the temperature controller that described sample culturing case is bathed by pipeline and circulating distilled water is connected.
2. multimode controlling temp type blood oxygen pressure kinetic test device according to claim 1, its characteristics be, described sample culturing case is airtight sample culturing case.
3. multimode controlling temp type blood oxygen pressure kinetic test device according to claim 1, its characteristics be, described computer controller and temperature controller are provided with data storage cell.
4. multimode controlling temp type blood oxygen pressure kinetic test device according to claim 1, its characteristics are, on connecting pipe, the gas pressure sensor control valve are installed between the first Rose Box, the second Rose Box, the 3rd Rose Box.
5. according to the described multimode controlling temp type of claim 1 or 4 blood oxygen pressure kinetic test device, its characteristics are, in the first Rose Box, the second Rose Box, the 3rd Rose Box, are provided with horizontal positioned and filter filter paper.
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| CN201310346461.XA CN103405235B (en) | 2013-08-09 | 2013-08-09 | Multi-mode temperature control dynamic test device for blood oxygen differential pressure |
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| CN201310346461.XA CN103405235B (en) | 2013-08-09 | 2013-08-09 | Multi-mode temperature control dynamic test device for blood oxygen differential pressure |
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| CN103405235B CN103405235B (en) | 2016-03-02 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104864898A (en) * | 2014-02-20 | 2015-08-26 | 中国科学院广州生物医药与健康研究院 | Proofreading system of sensor measurement values in biological culture box and proofreading method of sensor measurement values in biological culture box |
| CN108300659A (en) * | 2017-12-30 | 2018-07-20 | 宁波大学 | Cell incubator and its working method |
| CN111103158A (en) * | 2019-12-18 | 2020-05-05 | 广电计量检测(深圳)有限公司 | Calibration device and method for percutaneous partial pressure monitor |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104864898A (en) * | 2014-02-20 | 2015-08-26 | 中国科学院广州生物医药与健康研究院 | Proofreading system of sensor measurement values in biological culture box and proofreading method of sensor measurement values in biological culture box |
| CN104864898B (en) * | 2014-02-20 | 2019-04-23 | 中国科学院广州生物医药与健康研究院 | The critique system and method for measurement value sensor in bio-incubator |
| CN108300659A (en) * | 2017-12-30 | 2018-07-20 | 宁波大学 | Cell incubator and its working method |
| CN111103158A (en) * | 2019-12-18 | 2020-05-05 | 广电计量检测(深圳)有限公司 | Calibration device and method for percutaneous partial pressure monitor |
| CN111103158B (en) * | 2019-12-18 | 2021-11-16 | 广电计量检测(深圳)有限公司 | Calibration device and method for percutaneous partial pressure monitor |
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