CN202619631U - Dynamic-change synchronic measurement and recording device for small animal oxygen consumption - Google Patents
Dynamic-change synchronic measurement and recording device for small animal oxygen consumption Download PDFInfo
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- CN202619631U CN202619631U CN 201220063167 CN201220063167U CN202619631U CN 202619631 U CN202619631 U CN 202619631U CN 201220063167 CN201220063167 CN 201220063167 CN 201220063167 U CN201220063167 U CN 201220063167U CN 202619631 U CN202619631 U CN 202619631U
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Abstract
The utility model discloses a dynamic-change synchronic measurement and recording device for small animal oxygen consumption. The dynamic-change synchronic measurement and recording device comprises an animal cabin, an absorbent bottle is arranged in the animal cabin, an upper opening of the animal cabin is connected with a first water detection meter, two electrodes of the first water detection meter are connected with a control system of a first relay, two ends of the control system of the first relay are respectively connected with a pure oxygen storage bottle and the animal cabin through rubber pipes, an upper opening of the pure oxygen storage bottle is connected wit a second water detection meter, two electrodes of the second water detection meter are connected with a control system of a second relay, two ends of the control system of the second relay are respectively connected with the pure oxygen storage bottle and a water storage bottle through rubber pipes, the water storage bottle is arranged on a balance, and the balance is connected with a computer through a data output line. The dynamic-change synchronic measurement and recording device for small animal oxygen consumption is a set of gas-liquid linkage and real time recording device, has the advantages of multiple in channels, capable of automatically recording in real time and accurate in data record, can be used for automatically and continuously measuring and recording whole animal oxygen consumption and oxygen consumption speed of various models, and is simple, convenient, efficient and accurate to test.
Description
Technical field
This utility model relates to a kind of experimental provision of medicine and pharmacology, specifically, relates to the dynamic change of a kind of toy oxygen consumption and measures synchronously and recording equipment.
Background technology
The mensuration of toy oxygen consumption index and the evaluation of hypoxia-bearing capability are one of important contents of anoxia enduring drug screening and Mechanism Study.The mensuration of toy oxygen consumption index mainly is according to placing the animal of hermetic container to absorb airborne oxygen; Release of carbon dioxide; Thereby carbon dioxide is cooked the carbon-dioxide absorbent absorption by an amount of sodica calx hermetic container pressure is reduced, measure the quality of oxygen, air or the water of external compensation then and carry out the calculating of animal oxygen consumption and oxygen consumption speed.No matter be to measure the toy oxygen consumption in home or the low-oxygen environment,, will make the work of toy oxygen consumption mensuration more accurately, conveniently undoubtedly if the dynamic change of a kind of toy oxygen consumption monitoring and recording equipment are in real time arranged.Mostly at present researcher is homemade various oxygenating and determinator if using; Need distance that people's close observation and manual record move such as the entering quantity of a certain size oxygen bubble in the certain hour what, water column etc. in the mensuration process, in the manual record process, need great amount of manpower and personal error inevitable.
The utility model content
In order to solve the problem that exists in the prior art, this utility model provides the dynamic change of a kind of toy oxygen consumption to measure synchronously and recording equipment, and solving prior art small-animal oxygen consumption index determining wastes time and energy the problem that error is big.
This utility model is realized through following technical scheme:
The dynamic change of a kind of toy oxygen consumption is measured and recording equipment synchronously, comprises animal capsule, places the absorbent bottle in the said animal capsule; Animal capsule connection first water inspection suitable for reading meter; Two electrodes of first water inspection meter link to each other with first relay control system, and the two ends of first relay control system link to each other with animal capsule with the pure oxygen storage bottle respectively through rubber tube, pure oxygen storage bottle connection second water inspection suitable for reading meter; Two electrodes of second water inspection meter link to each other with second relay control system; The two ends of second relay control system link to each other with the water storage bottle with the pure oxygen storage bottle respectively through rubber tube, and the water storage bottle places on the balance, and balance is connected with computer through DOL Data Output Line.
Said pure oxygen storage bottle places in the constant water bath box, is placed with the liquid paraffin of certain volume in the pure oxygen storage bottle.
The dynamic change of a kind of toy oxygen consumption is measured and recording equipment synchronously, comprises animal capsule, places the absorbent bottle in the said animal capsule; Animal capsule is divided into two parts up and down, and the centre is provided with dividing plate with holes, animal capsule connection water inspection suitable for reading meter; Two electrodes of water inspection meter link to each other with relay control system; The two ends of relay control system link to each other with the water storage bottle with animal capsule the lower partition respectively through rubber tube, and the water storage bottle places on the balance, and balance is connected with computer through DOL Data Output Line.
Said computer is equipped with the weight change logging software.
Carbon-dioxide absorbent sodica calx and aqueous absorbent calcium chloride are housed in the said absorbent bottle.
The beneficial effect of this utility model is: this utility model is through the signals collecting of automatic oxygenating and water charging system and water storage bottle weight change, and oxygen consumption of animal and oxygen consumption rate process can be advanced in the Microsoft Office Excel document to be convenient to date processing and mapping by automatic successive record in the animal capsule.Because the weight change logging software is can multichannel (number of active lanes is identical with the balance number of computer connection); Such as the oxygen consumption dynamic change that can carry out 3 even more animal simultaneously monitoring and automatically and continuously recording in real time; Not only save manpower but also result of the test is accurate, convenient data processing.
This utility model has been set up the gas-liquid linked and real time record device of a cover; Has multi-path, automatic time record, record data advantage accurately; Can be used for the whole animal oxygen consumption of the multiple model of automatic METHOD FOR CONTINUOUS DETERMINATION and the mensuration and the record of oxygen consumption speed, test easy, efficient, accurate.
Description of drawings
Fig. 1 is that the dynamic change of this utility model toy oxygen consumption is measured and recording equipment synchronously;
Fig. 2 is the another kind of embodiment of synchronous mensuration of this utility model toy oxygen consumption dynamic change and recording equipment.
The specific embodiment
Below in conjunction with accompanying drawing this utility model is further specified.
Embodiment 1
As shown in Figure 1; In the animal capsule 15 because animal 17 continuous oxygen intakes; The carbon dioxide that produces is absorbed in the agent bottle 16 sodica calx and absorbs and first water inspection meter, 13 water columns are flowed to animal capsule 15 internal direction; All immerse that short electrode breaks away from the circuit triggers that liquid level makes liquid level relay 12 in two electrodes 14 of normal saline liquid levels liquid level relay 12 down, open the air intake valve of controlling automatic air intake installation, through rubber tube 11 to animal capsule 15 oxygen supplys; Thereby behind the oxygen that has compensated animals consuming animal capsule 15 internal gas pressures will raise make water inspection meter 13 water columns to animal capsule 15 out of my cabin direction flow; Two electrodes 14 of liquid level relay 12 all immerse again under the normal saline liquid level, and the air intake valve of the automatic air intake installation of liquid level relay 12 closing control stops to animal capsule 15 oxygen supplys; Thereby this process is gone round and begun again and is realized that animal capsule 15 composition of gases within and pressure remain on animal and just got into animal capsule 15 and enclosure level behind the door.If the mensuration of normal pressure oxygen consumption, then the gas componant in the animal capsule 15 is identical with animal capsule 15 outer atmosphere with pressure; If enclosure makes an experiment after feeding low-oxygen gas mixture behind the door and adjusting cabin external and internal pressure unanimity, then the gas componant in the animal capsule remains on the level of low-oxygen gas mixture, and its internal pressure is with atmospheric pressure is identical out of my cabin.
The volume that second water that communicates with pure oxygen storage bottle 7 inspection meter 8 is controlled second relay control system 6 through the variation of its two electrode 9 perception water levels inlet valve flows into oxygen in the animal capsules 15 through rubber tube 5 compensation is to keep the constant of its internal pressure.Compensated the animal oxygen consumption water manometer 8 water columns that communicate with it are flowed to pure oxygen storage bottle 7 internal direction owing to oxygen wherein flows into animal capsule 15 in the pure oxygen storage bottle 7, the inlet valve of the automatic water inflow control system 6 of second liquid level relay is opened to pure oxygen storage bottle 7 private water supplies; The volume of the volume of the water of 1ml and 1ml oxygen is identical under the stationary temperature condition, and the quality of water is constant and can measures with balance; To raise and make water manometer 8 water columns mobile thereby compensated behind the oxygen that flows into animal capsule 15 pure oxygen storage bottle 7 internal gas pressures when the water that flows into, thereby the inlet valve of the automatic water inflow control system 6 of second liquid level relay is closed and stopped to intake to the pure oxygen storage bottle to pure oxygen storage bottle 7 outside directions; Thereby this process is gone round and begun again and is realized that gas pressure keeps constant in the pure oxygen storage bottle 7; The liquid paraffin (like 20ml) of putting into certain volume in the pure oxygen storage bottle 7 stops the oxygen and the oxygen of bottle to dissolve in the decline of water build-up of pressure to form the paraffin oil reservoir.Because the volume of gas receives Influence of Temperature easily, so the pure oxygen storage bottle is whole is put in the constant water bath box 10.
The water that flows into pure oxygen storage bottle 7 is to be supplied with by the water storage bottle 4 that is put on the balance 3, and its number of dropouts is passed through the computer 1 automatic successive record that balance DOL Data Output Line 2 is mounted the weight change logging software and advanced in the Microsoft Office Excel document to be convenient to date processing and mapping real-time.
Oxygen consumption and oxygen consumption rate process through animal in the above process animal capsule just can be advanced in the Microsoft Office Excel document to be convenient to date processing and mapping by automatic successive record.Logging software is WeightRecorder v1.2.0, and precision is 0.1g, can be continuously with certain hour record data at interval, record data in the time of also can only water storage bottle weight changes when water inlet.Machine time and water storage bottle weight strict synchronism at that time.
Test Example:
Use the dynamic change of toy oxygen consumption monitoring and automatically and continuously recording device in real time, observed normal rat at normal oxygen of normal pressure and the oxygen consumption of simulating in the 6000m normal pressure low oxygen environment, device runs well.
1. experimental technique: get 3 of body weight 500～520g SD male rats.Put into animal capsule after rat weighed, the about 5L of animal capsule internal volume, enclosure carry out the mensuration of oxygen consumption behind the door immediately.Microsoft Office Excel document is gone in variation according to 15 seconds interval record water storage bottle weight, writes down 15 minutes.The normal oxygen rat of normal pressure oxygen consumption is measured the back and in animal capsule, is fed the low-oxygen gas mixture (being equivalent to simulate the environment of low oxygen plateau of 6000m) 15 minutes that contains 10% oxygen, and flow is 5L/min.Stop the inside and outside pressure of low-oxygen gas mixture ventilation back adjustment animal capsule and simulate the mensuration of the oxygen consumption of rat in the 6000m normal pressure low oxygen environment after identical immediately; Microsoft Office Excel document is gone in variation according to 15 seconds interval record water storage bottle weight, writes down 15 minutes.Utilize Microsoft Office Excel to carry out the calculating of oxygen consumption.The animal oxygen consumption is steady in 15 minutes, and the slope of the regression curve that data carry out obtaining behind the linear regression is the oxygen consumption of animal again divided by body weight.
2. experimental result: normal oxygen of normal pressure and normal pressure low oxygen rat oxygen consumption are respectively (22.1 ± 2.5) ml O
2/ (kg.min) with (13.9 ± 1.9) ml O
2/ (kg.min).
Embodiment 2
Present embodiment is the another kind of embodiment of this utility model; Be that with the difference of embodiment 1 water that compensates directly gets into animal capsule 9 bottoms; Animal capsule is divided into two parts up and down; The centre is provided with dividing plate with holes 12, and animal capsule 9 its tops have opening to link to each other with an end of water manometer 7, and the other end is placed two electrodes 8 and linked to each other with automatic control system 6.As shown in Figure 2; In the animal capsule 9 because animal 10 continuous oxygen intakes; The carbon dioxide that produces is absorbed by the sodica calx in the absorption bottle in the animal capsule 9 11 and water manometer 7 water columns is flowed to animal capsule 9 internal direction; All immerse that short electrode breaks away from the circuit triggers that liquid level makes liquid level relay in two electrodes 8 of normal saline liquid levels liquid level relay control system 6 down, open the inlet valve of control automatic water inflow device, through rubber water pipe 5 to animal capsule 9 water supply; Thereby behind the water of the equal volume of the oxygen that has compensated animals consuming animal capsule 9 internal gas pressures will raise make water manometer 7 water columns to animal capsule 9 out of my cabin direction flow; Two electrodes 8 of liquid level relay control system 6 all immerse again under the normal saline liquid level, and liquid level relay control system 6 is closed inlet valve and stopped to supply water to animal capsule 9; Thereby this process is gone round and begun again and is realized that gas pressure keeps identical with animal capsule 9 outer atmospheric pressure in the animal capsule 9.
The water that flows into animal capsule 9 is to be supplied with by the water storage bottle 4 that is put on the balance 3, and its number of dropouts is passed through the computer 1 automatic successive record that balance DOL Data Output Line 2 is mounted the weight change logging software and advanced in the Microsoft Office Excel document to be convenient to date processing and mapping real-time.
Oxygen consumption and oxygen consumption rate process through animal in the above process animal capsule just can be advanced in the Microsoft Office Excel document to be convenient to date processing and mapping by automatic successive record.
Logging software is WeightRecorder v1.2.0, and precision is 0.1g, can be continuously with certain hour record data at interval, record data in the time of also can only water storage bottle weight changes when water inlet.Machine time and water storage bottle weight strict synchronism at that time.
Test Example:
Animal anoxia enduring and oxygen consumption dynamic change are measured synchronously in the mice normal pressure airtight anoxia model.
1. experimental technique: get 8 of body weight 35～42g SD male mices.Put into animal capsule after mice weighed, the about 550ml of animal capsule internal volume, enclosure carry out the mensuration of oxygen consumption behind the door immediately.Microsoft Office Excel document is gone in variation according to 3 seconds interval record water storage bottle weight, writes down 20 minutes.More than the automatic control water inlet system of device directly links to each other with the animal capsule (the about 550ml of volume) of placing mice, and animal capsule is divided into two parts up and down, opens (Fig. 2) in 12 minutes to utilize gas exchange with foraminous dividing plate.
2. experimental result
The airtight mice of representational normal pressure time-curvilinear regression of accumulative total oxygen consumption analyzes, its process meets quadratic equation with one unknown.Time-to-live average out to (46.5 ± 4.6) min of normal mouse, oxygen consumption total amount is (75.0 ± 9.9) ml O when dead
2
Claims (4)
1. toy oxygen consumption dynamic change is measured and recording equipment synchronously; It is characterized in that, comprise animal capsule, place the absorbent bottle in the said animal capsule; Animal capsule connection first water inspection suitable for reading meter; Two electrodes of first water inspection meter link to each other with first relay control system, and the two ends of first relay control system link to each other with animal capsule with the pure oxygen storage bottle respectively through rubber tube, pure oxygen storage bottle connection second water inspection suitable for reading meter; Two electrodes of second water inspection meter link to each other with second relay control system; The two ends of second relay control system link to each other with the water storage bottle with the pure oxygen storage bottle respectively through rubber tube, and the water storage bottle places on the balance, and balance is connected with computer through DOL Data Output Line.
2. toy oxygen consumption according to claim 1 dynamic change is measured and recording equipment synchronously, it is characterized in that said pure oxygen storage bottle places in the constant water bath box.
3. toy oxygen consumption according to claim 1 dynamic change is measured and recording equipment synchronously, it is characterized in that, is placed with liquid paraffin in the said pure oxygen storage bottle.
4. toy oxygen consumption dynamic change is measured and recording equipment synchronously, it is characterized in that, comprises animal capsule; Place the absorbent bottle in the said animal capsule; Animal capsule is divided into two parts up and down, and the centre is provided with dividing plate with holes, animal capsule connection water inspection suitable for reading meter; Two electrodes of water inspection meter link to each other with relay control system; The two ends of relay control system link to each other with the water storage bottle with animal capsule the lower partition respectively through rubber tube, and the water storage bottle places on the balance, and balance is connected with computer through DOL Data Output Line.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201220063167 CN202619631U (en) | 2012-02-24 | 2012-02-24 | Dynamic-change synchronic measurement and recording device for small animal oxygen consumption |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201220063167 CN202619631U (en) | 2012-02-24 | 2012-02-24 | Dynamic-change synchronic measurement and recording device for small animal oxygen consumption |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN202619631U true CN202619631U (en) | 2012-12-26 |
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ID=47372885
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201220063167 Withdrawn - After Issue CN202619631U (en) | 2012-02-24 | 2012-02-24 | Dynamic-change synchronic measurement and recording device for small animal oxygen consumption |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102579006A (en) * | 2012-02-24 | 2012-07-18 | 中国人民解放军军事医学科学院卫生学环境医学研究所 | Device for simultaneous measurement and recording of oxygen consumption dynamic change of small animal |
| CN103340629A (en) * | 2013-05-29 | 2013-10-09 | 浙江大学 | Method for dynamically determining breathing oxygen consumption and hypoxia device for same |
-
2012
- 2012-02-24 CN CN 201220063167 patent/CN202619631U/en not_active Withdrawn - After Issue
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102579006A (en) * | 2012-02-24 | 2012-07-18 | 中国人民解放军军事医学科学院卫生学环境医学研究所 | Device for simultaneous measurement and recording of oxygen consumption dynamic change of small animal |
| CN102579006B (en) * | 2012-02-24 | 2013-07-10 | 中国人民解放军军事医学科学院卫生学环境医学研究所 | Device for simultaneous measurement and recording of oxygen consumption dynamic change of small animal |
| CN103340629A (en) * | 2013-05-29 | 2013-10-09 | 浙江大学 | Method for dynamically determining breathing oxygen consumption and hypoxia device for same |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| AV01 | Patent right actively abandoned |
Granted publication date: 20121226 Effective date of abandoning: 20130710 |
|
| AV01 | Patent right actively abandoned |
Granted publication date: 20121226 Effective date of abandoning: 20130710 |
|
| RGAV | Abandon patent right to avoid regrant |