CN103393576B - A kind of mangosteen extract and application thereof - Google Patents
A kind of mangosteen extract and application thereof Download PDFInfo
- Publication number
- CN103393576B CN103393576B CN201310340403.6A CN201310340403A CN103393576B CN 103393576 B CN103393576 B CN 103393576B CN 201310340403 A CN201310340403 A CN 201310340403A CN 103393576 B CN103393576 B CN 103393576B
- Authority
- CN
- China
- Prior art keywords
- mangosteen
- extract
- mangosteen extract
- ethanol
- solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 240000006053 Garcinia mangostana Species 0.000 title claims abstract description 78
- 235000017048 Garcinia mangostana Nutrition 0.000 title claims abstract description 78
- 239000000284 extract Substances 0.000 title claims abstract description 57
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 88
- 239000000203 mixture Substances 0.000 claims description 31
- 238000000605 extraction Methods 0.000 claims description 18
- 239000002904 solvent Substances 0.000 claims description 17
- 238000010521 absorption reaction Methods 0.000 claims description 16
- 239000000843 powder Substances 0.000 claims description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 13
- 230000006837 decompression Effects 0.000 claims description 12
- 238000001035 drying Methods 0.000 claims description 12
- 239000000706 filtrate Substances 0.000 claims description 12
- 238000011084 recovery Methods 0.000 claims description 12
- 150000002148 esters Chemical class 0.000 claims description 6
- 229930003944 flavone Natural products 0.000 claims description 6
- 235000011949 flavones Nutrition 0.000 claims description 6
- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 claims description 5
- 150000002212 flavone derivatives Chemical class 0.000 claims description 5
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 5
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 claims description 5
- 238000002329 infrared spectrum Methods 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 3
- 239000008367 deionised water Substances 0.000 claims description 2
- 229910021641 deionized water Inorganic materials 0.000 claims description 2
- 239000004615 ingredient Substances 0.000 claims description 2
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims 1
- 125000005250 alkyl acrylate group Chemical group 0.000 claims 1
- CBTVGIZVANVGBH-UHFFFAOYSA-N aminomethyl propanol Chemical compound CC(C)(N)CO CBTVGIZVANVGBH-UHFFFAOYSA-N 0.000 claims 1
- 229920006037 cross link polymer Polymers 0.000 claims 1
- 239000002537 cosmetic Substances 0.000 abstract description 15
- 230000002087 whitening effect Effects 0.000 abstract description 8
- 239000003814 drug Substances 0.000 abstract description 5
- 235000013402 health food Nutrition 0.000 abstract description 2
- 230000002605 anti-dotal effect Effects 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 description 21
- 239000000243 solution Substances 0.000 description 20
- 238000010828 elution Methods 0.000 description 17
- -1 dimethyl sulfoxine Chemical compound 0.000 description 16
- 238000012360 testing method Methods 0.000 description 16
- 239000000523 sample Substances 0.000 description 14
- 239000007788 liquid Substances 0.000 description 11
- 239000003921 oil Substances 0.000 description 11
- 235000019198 oils Nutrition 0.000 description 11
- 230000000694 effects Effects 0.000 description 10
- 229920005989 resin Polymers 0.000 description 10
- 239000011347 resin Substances 0.000 description 10
- 239000001993 wax Substances 0.000 description 10
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 9
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 9
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 9
- 238000002835 absorbance Methods 0.000 description 9
- 239000003960 organic solvent Substances 0.000 description 9
- 239000012071 phase Substances 0.000 description 9
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 8
- 239000000287 crude extract Substances 0.000 description 7
- 239000000839 emulsion Substances 0.000 description 7
- 230000007760 free radical scavenging Effects 0.000 description 7
- 229930195733 hydrocarbon Natural products 0.000 description 7
- 150000002430 hydrocarbons Chemical class 0.000 description 7
- 230000002401 inhibitory effect Effects 0.000 description 7
- 239000000463 material Substances 0.000 description 7
- 239000004215 Carbon black (E152) Substances 0.000 description 6
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 6
- 239000000546 pharmaceutical excipient Substances 0.000 description 6
- 238000010998 test method Methods 0.000 description 5
- 239000002253 acid Substances 0.000 description 4
- 239000003463 adsorbent Substances 0.000 description 4
- 239000008346 aqueous phase Substances 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 4
- 235000013399 edible fruits Nutrition 0.000 description 4
- MNWFXJYAOYHMED-UHFFFAOYSA-N heptanoic acid Chemical compound CCCCCCC(O)=O MNWFXJYAOYHMED-UHFFFAOYSA-N 0.000 description 4
- 239000013641 positive control Substances 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- 238000001179 sorption measurement Methods 0.000 description 4
- 239000002562 thickening agent Substances 0.000 description 4
- 239000000341 volatile oil Substances 0.000 description 4
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 3
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 3
- JMGZEFIQIZZSBH-UHFFFAOYSA-N Bioquercetin Natural products CC1OC(OCC(O)C2OC(OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5)C(O)C2O)C(O)C(O)C1O JMGZEFIQIZZSBH-UHFFFAOYSA-N 0.000 description 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 3
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 3
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 3
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 3
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 3
- 230000003796 beauty Effects 0.000 description 3
- 239000004205 dimethyl polysiloxane Substances 0.000 description 3
- 235000013870 dimethyl polysiloxane Nutrition 0.000 description 3
- IVTMALDHFAHOGL-UHFFFAOYSA-N eriodictyol 7-O-rutinoside Natural products OC1C(O)C(O)C(C)OC1OCC1C(O)C(O)C(O)C(OC=2C=C3C(C(C(O)=C(O3)C=3C=C(O)C(O)=CC=3)=O)=C(O)C=2)O1 IVTMALDHFAHOGL-UHFFFAOYSA-N 0.000 description 3
- 239000000945 filler Substances 0.000 description 3
- 229910052500 inorganic mineral Inorganic materials 0.000 description 3
- 150000002632 lipids Chemical class 0.000 description 3
- 239000011707 mineral Substances 0.000 description 3
- 229920001206 natural gum Polymers 0.000 description 3
- 239000000049 pigment Substances 0.000 description 3
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 3
- FDRQPMVGJOQVTL-UHFFFAOYSA-N quercetin rutinoside Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 FDRQPMVGJOQVTL-UHFFFAOYSA-N 0.000 description 3
- 150000003254 radicals Chemical class 0.000 description 3
- IKGXIBQEEMLURG-BKUODXTLSA-N rutin Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@@H]1OC[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 IKGXIBQEEMLURG-BKUODXTLSA-N 0.000 description 3
- ALABRVAAKCSLSC-UHFFFAOYSA-N rutin Natural products CC1OC(OCC2OC(O)C(O)C(O)C2O)C(O)C(O)C1OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5 ALABRVAAKCSLSC-UHFFFAOYSA-N 0.000 description 3
- 235000005493 rutin Nutrition 0.000 description 3
- 229960004555 rutoside Drugs 0.000 description 3
- 239000012488 sample solution Substances 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 150000005846 sugar alcohols Polymers 0.000 description 3
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 description 2
- GLCFQKXOQDQJFZ-UHFFFAOYSA-N 2-ethylhexyl 12-hydroxyoctadecanoate Chemical compound CCCCCCC(O)CCCCCCCCCCC(=O)OCC(CC)CCCC GLCFQKXOQDQJFZ-UHFFFAOYSA-N 0.000 description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 241001597008 Nomeidae Species 0.000 description 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 241000191967 Staphylococcus aureus Species 0.000 description 2
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 2
- 102000003425 Tyrosinase Human genes 0.000 description 2
- 108060008724 Tyrosinase Proteins 0.000 description 2
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 2
- 239000013543 active substance Substances 0.000 description 2
- 230000001476 alcoholic effect Effects 0.000 description 2
- 150000001298 alcohols Chemical class 0.000 description 2
- 239000003513 alkali Substances 0.000 description 2
- 150000001336 alkenes Chemical class 0.000 description 2
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 description 2
- VSCWAEJMTAWNJL-UHFFFAOYSA-K aluminium trichloride Chemical compound Cl[Al](Cl)Cl VSCWAEJMTAWNJL-UHFFFAOYSA-K 0.000 description 2
- 230000003712 anti-aging effect Effects 0.000 description 2
- 230000002421 anti-septic effect Effects 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 229920001577 copolymer Polymers 0.000 description 2
- IEJIGPNLZYLLBP-UHFFFAOYSA-N dimethyl carbonate Chemical compound COC(=O)OC IEJIGPNLZYLLBP-UHFFFAOYSA-N 0.000 description 2
- KPUWHANPEXNPJT-UHFFFAOYSA-N disiloxane Chemical class [SiH3]O[SiH3] KPUWHANPEXNPJT-UHFFFAOYSA-N 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 230000001815 facial effect Effects 0.000 description 2
- 150000002191 fatty alcohols Chemical class 0.000 description 2
- 229930003935 flavonoid Natural products 0.000 description 2
- 150000002215 flavonoids Chemical class 0.000 description 2
- 235000017173 flavonoids Nutrition 0.000 description 2
- 239000000499 gel Substances 0.000 description 2
- 150000004676 glycans Chemical class 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 230000002209 hydrophobic effect Effects 0.000 description 2
- 238000011534 incubation Methods 0.000 description 2
- TZIHFWKZFHZASV-UHFFFAOYSA-N methyl formate Chemical compound COC=O TZIHFWKZFHZASV-UHFFFAOYSA-N 0.000 description 2
- 239000013642 negative control Substances 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 239000008363 phosphate buffer Substances 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 235000013824 polyphenols Nutrition 0.000 description 2
- 229920001282 polysaccharide Polymers 0.000 description 2
- 239000005017 polysaccharide Substances 0.000 description 2
- 230000002000 scavenging effect Effects 0.000 description 2
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 description 2
- 229920002545 silicone oil Polymers 0.000 description 2
- 229920002050 silicone resin Polymers 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000007921 spray Substances 0.000 description 2
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 2
- 230000007704 transition Effects 0.000 description 2
- 235000015112 vegetable and seed oil Nutrition 0.000 description 2
- 239000008158 vegetable oil Substances 0.000 description 2
- JNELGWHKGNBSMD-UHFFFAOYSA-N xanthone Chemical compound C1=CC=C2C(=O)C3=CC=CC=C3OC2=C1 JNELGWHKGNBSMD-UHFFFAOYSA-N 0.000 description 2
- RTBWWWVNZWFNBV-SFHVURJKSA-N (2s)-3-phenyl-2-(undec-10-enoylamino)propanoic acid Chemical compound C=CCCCCCCCCC(=O)N[C@H](C(=O)O)CC1=CC=CC=C1 RTBWWWVNZWFNBV-SFHVURJKSA-N 0.000 description 1
- ALSTYHKOOCGGFT-KTKRTIGZSA-N (9Z)-octadecen-1-ol Chemical compound CCCCCCCC\C=C/CCCCCCCCO ALSTYHKOOCGGFT-KTKRTIGZSA-N 0.000 description 1
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 1
- ULQISTXYYBZJSJ-UHFFFAOYSA-N 12-hydroxyoctadecanoic acid Chemical compound CCCCCCC(O)CCCCCCCCCCC(O)=O ULQISTXYYBZJSJ-UHFFFAOYSA-N 0.000 description 1
- ZEMPKEQAKRGZGQ-AAKVHIHISA-N 2,3-bis[[(z)-12-hydroxyoctadec-9-enoyl]oxy]propyl (z)-12-hydroxyoctadec-9-enoate Chemical compound CCCCCCC(O)C\C=C/CCCCCCCC(=O)OCC(OC(=O)CCCCCCC\C=C/CC(O)CCCCCC)COC(=O)CCCCCCC\C=C/CC(O)CCCCCC ZEMPKEQAKRGZGQ-AAKVHIHISA-N 0.000 description 1
- HIXDQWDOVZUNNA-UHFFFAOYSA-N 2-(3,4-dimethoxyphenyl)-5-hydroxy-7-methoxychromen-4-one Chemical compound C=1C(OC)=CC(O)=C(C(C=2)=O)C=1OC=2C1=CC=C(OC)C(OC)=C1 HIXDQWDOVZUNNA-UHFFFAOYSA-N 0.000 description 1
- KIHBGTRZFAVZRV-UHFFFAOYSA-N 2-Hydroxyoctadecanoic acid Natural products CCCCCCCCCCCCCCCCC(O)C(O)=O KIHBGTRZFAVZRV-UHFFFAOYSA-N 0.000 description 1
- XULHFMYCBKQGEE-UHFFFAOYSA-N 2-hexyl-1-Decanol Chemical compound CCCCCCCCC(CO)CCCCCC XULHFMYCBKQGEE-UHFFFAOYSA-N 0.000 description 1
- LEACJMVNYZDSKR-UHFFFAOYSA-N 2-octyldodecan-1-ol Chemical compound CCCCCCCCCCC(CO)CCCCCCCC LEACJMVNYZDSKR-UHFFFAOYSA-N 0.000 description 1
- CYSSSYKSBHKJQE-UHFFFAOYSA-N 2-undecylpentadecan-1-ol Chemical compound CCCCCCCCCCCCCC(CO)CCCCCCCCCCC CYSSSYKSBHKJQE-UHFFFAOYSA-N 0.000 description 1
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 description 1
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 description 1
- 239000005995 Aluminium silicate Substances 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- PZNSFCLAULLKQX-UHFFFAOYSA-N Boron nitride Chemical compound N#B PZNSFCLAULLKQX-UHFFFAOYSA-N 0.000 description 1
- 241000195940 Bryophyta Species 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 239000005632 Capric acid (CAS 334-48-5) Substances 0.000 description 1
- HJTVQHVGMGKONQ-LUZURFALSA-N Curcumin II Natural products C1=C(O)C(OC)=CC(\C=C\C(=O)CC(=O)\C=C\C=2C=CC(O)=CC=2)=C1 HJTVQHVGMGKONQ-LUZURFALSA-N 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- XMSXQFUHVRWGNA-UHFFFAOYSA-N Decamethylcyclopentasiloxane Chemical compound C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1 XMSXQFUHVRWGNA-UHFFFAOYSA-N 0.000 description 1
- GHVNFZFCNZKVNT-UHFFFAOYSA-N Decanoic acid Natural products CCCCCCCCCC(O)=O GHVNFZFCNZKVNT-UHFFFAOYSA-N 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 102000016942 Elastin Human genes 0.000 description 1
- 108010014258 Elastin Proteins 0.000 description 1
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 description 1
- ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 description 1
- 229940123457 Free radical scavenger Drugs 0.000 description 1
- BIVBRWYINDPWKA-VLQRKCJKSA-L Glycyrrhizinate dipotassium Chemical compound [K+].[K+].O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C(O)=O)C([O-])=O)[C@@H]1O[C@H](C([O-])=O)[C@@H](O)[C@H](O)[C@H]1O BIVBRWYINDPWKA-VLQRKCJKSA-L 0.000 description 1
- 238000004566 IR spectroscopy Methods 0.000 description 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 1
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N Lactic Acid Natural products CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 1
- 241000446313 Lamella Species 0.000 description 1
- QTDMGAWIBXJNRR-UHFFFAOYSA-N Mangostin Natural products CC(=CCc1c(O)cc2Oc3cc(C)c(O)c(CC=C(C)C)c3C(=O)c2c1O)C QTDMGAWIBXJNRR-UHFFFAOYSA-N 0.000 description 1
- RJQXTJLFIWVMTO-TYNCELHUSA-N Methicillin Chemical compound COC1=CC=CC(OC)=C1C(=O)N[C@@H]1C(=O)N2[C@@H](C(O)=O)C(C)(C)S[C@@H]21 RJQXTJLFIWVMTO-TYNCELHUSA-N 0.000 description 1
- 239000004677 Nylon Substances 0.000 description 1
- 244000025272 Persea americana Species 0.000 description 1
- 235000008673 Persea americana Nutrition 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- 239000004809 Teflon Substances 0.000 description 1
- 229920006362 Teflon® Polymers 0.000 description 1
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 1
- 206010053615 Thermal burn Diseases 0.000 description 1
- 208000005946 Xerostomia Diseases 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 238000004847 absorption spectroscopy Methods 0.000 description 1
- 229920006221 acetate fiber Polymers 0.000 description 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 239000000443 aerosol Substances 0.000 description 1
- 150000001335 aliphatic alkanes Chemical class 0.000 description 1
- 229960000458 allantoin Drugs 0.000 description 1
- QMAYBMKBYCGXDH-SOUVJXGZSA-N alpha-Cadinene Natural products C1CC(C)=C[C@@H]2[C@H](C(C)C)CC=C(C)[C@@H]21 QMAYBMKBYCGXDH-SOUVJXGZSA-N 0.000 description 1
- QMAYBMKBYCGXDH-UHFFFAOYSA-N alpha-amorphene Natural products C1CC(C)=CC2C(C(C)C)CC=C(C)C21 QMAYBMKBYCGXDH-UHFFFAOYSA-N 0.000 description 1
- QMAYBMKBYCGXDH-KKUMJFAQSA-N alpha-cadinene Chemical compound C1CC(C)=C[C@H]2[C@H](C(C)C)CC=C(C)[C@@H]21 QMAYBMKBYCGXDH-KKUMJFAQSA-N 0.000 description 1
- GNRIZKKCNOBBMO-UHFFFAOYSA-N alpha-mangostin Chemical compound OC1=C(CC=C(C)C)C(O)=C2C(=O)C3=C(CC=C(C)C)C(OC)=C(O)C=C3OC2=C1 GNRIZKKCNOBBMO-UHFFFAOYSA-N 0.000 description 1
- ZVFQDLCERPGZMO-UHFFFAOYSA-N alpha-mangostin Natural products OC1=C(CC=C(C)C)C(O)=C2C(=O)C3=C(CC=C(C)C)C(OC)=C(O)C=C3CC2=C1 ZVFQDLCERPGZMO-UHFFFAOYSA-N 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- 235000012211 aluminium silicate Nutrition 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 230000001741 anti-phlogistic effect Effects 0.000 description 1
- 230000001754 anti-pyretic effect Effects 0.000 description 1
- 239000000043 antiallergic agent Substances 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- BTFJIXJJCSYFAL-UHFFFAOYSA-N arachidyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCO BTFJIXJJCSYFAL-UHFFFAOYSA-N 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 229910052788 barium Inorganic materials 0.000 description 1
- DSAJWYNOEDNPEQ-UHFFFAOYSA-N barium atom Chemical compound [Ba] DSAJWYNOEDNPEQ-UHFFFAOYSA-N 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 229920001222 biopolymer Polymers 0.000 description 1
- 239000012490 blank solution Substances 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 239000004204 candelilla wax Substances 0.000 description 1
- 229940073532 candelilla wax Drugs 0.000 description 1
- 235000013868 candelilla wax Nutrition 0.000 description 1
- KBPLFHHGFOOTCA-UHFFFAOYSA-N caprylic alcohol Natural products CCCCCCCCO KBPLFHHGFOOTCA-UHFFFAOYSA-N 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 150000001721 carbon Chemical group 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 239000006229 carbon black Substances 0.000 description 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 239000004203 carnauba wax Substances 0.000 description 1
- 239000007766 cera flava Substances 0.000 description 1
- 229910000420 cerium oxide Inorganic materials 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 229940086555 cyclomethicone Drugs 0.000 description 1
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 1
- 230000035614 depigmentation Effects 0.000 description 1
- 229960005215 dichloroacetic acid Drugs 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- XEYBRNLFEZDVAW-ARSRFYASSA-N dinoprostone Chemical compound CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O XEYBRNLFEZDVAW-ARSRFYASSA-N 0.000 description 1
- 229960002986 dinoprostone Drugs 0.000 description 1
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 206010013781 dry mouth Diseases 0.000 description 1
- 230000002849 elastaseinhibitory effect Effects 0.000 description 1
- 229920002549 elastin Polymers 0.000 description 1
- 239000003974 emollient agent Substances 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 125000004185 ester group Chemical group 0.000 description 1
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 description 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 1
- 150000002170 ethers Chemical class 0.000 description 1
- TVQGDYNRXLTQAP-UHFFFAOYSA-N ethyl heptanoate Chemical compound CCCCCCC(=O)OCC TVQGDYNRXLTQAP-UHFFFAOYSA-N 0.000 description 1
- 238000004299 exfoliation Methods 0.000 description 1
- 238000005562 fading Methods 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 150000002195 fatty ethers Chemical class 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 150000002213 flavones Chemical class 0.000 description 1
- 239000011737 fluorine Substances 0.000 description 1
- 229910052731 fluorine Inorganic materials 0.000 description 1
- NBVXSUQYWXRMNV-UHFFFAOYSA-N fluoromethane Chemical compound FC NBVXSUQYWXRMNV-UHFFFAOYSA-N 0.000 description 1
- ZHPNWZCWUUJAJC-UHFFFAOYSA-N fluorosilicon Chemical compound [Si]F ZHPNWZCWUUJAJC-UHFFFAOYSA-N 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000005283 ground state Effects 0.000 description 1
- IUJAMGNYPWYUPM-UHFFFAOYSA-N hentriacontane Chemical compound CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC IUJAMGNYPWYUPM-UHFFFAOYSA-N 0.000 description 1
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 1
- 229960001340 histamine Drugs 0.000 description 1
- 229920001519 homopolymer Polymers 0.000 description 1
- 229920006270 hydrocarbon resin Polymers 0.000 description 1
- 230000000640 hydroxylating effect Effects 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 239000001023 inorganic pigment Substances 0.000 description 1
- 239000000077 insect repellent Substances 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- WNWHHMBRJJOGFJ-UHFFFAOYSA-N isooctadecyl alcohol Natural products CC(C)CCCCCCCCCCCCCCCO WNWHHMBRJJOGFJ-UHFFFAOYSA-N 0.000 description 1
- 229940060384 isostearyl isostearate Drugs 0.000 description 1
- 229940119170 jojoba wax Drugs 0.000 description 1
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 208000006443 lactic acidosis Diseases 0.000 description 1
- 239000002502 liposome Substances 0.000 description 1
- 229940057995 liquid paraffin Drugs 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 229960003085 meticillin Drugs 0.000 description 1
- 244000000010 microbial pathogen Species 0.000 description 1
- 239000004200 microcrystalline wax Substances 0.000 description 1
- 239000004005 microsphere Substances 0.000 description 1
- 239000002480 mineral oil Substances 0.000 description 1
- 235000010446 mineral oil Nutrition 0.000 description 1
- 230000004898 mitochondrial function Effects 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 235000011929 mousse Nutrition 0.000 description 1
- 150000002790 naphthalenes Chemical class 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- SLCVBVWXLSEKPL-UHFFFAOYSA-N neopentyl glycol Chemical compound OCC(C)(C)CO SLCVBVWXLSEKPL-UHFFFAOYSA-N 0.000 description 1
- FBUKVWPVBMHYJY-UHFFFAOYSA-M nonanoate Chemical compound CCCCCCCCC([O-])=O FBUKVWPVBMHYJY-UHFFFAOYSA-M 0.000 description 1
- 235000008935 nutritious Nutrition 0.000 description 1
- 230000000050 nutritive effect Effects 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- 239000007764 o/w emulsion Substances 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- WQDGUYZIAJKLAB-UHFFFAOYSA-N octan-2-yl nitrite Chemical compound CCCCCCC(C)ON=O WQDGUYZIAJKLAB-UHFFFAOYSA-N 0.000 description 1
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- XMLQWXUVTXCDDL-UHFFFAOYSA-N oleyl alcohol Natural products CCCCCCC=CCCCCCCCCCCO XMLQWXUVTXCDDL-UHFFFAOYSA-N 0.000 description 1
- 229940055577 oleyl alcohol Drugs 0.000 description 1
- 239000012860 organic pigment Substances 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- BMMGVYCKOGBVEV-UHFFFAOYSA-N oxo(oxoceriooxy)cerium Chemical compound [Ce]=O.O=[Ce]=O BMMGVYCKOGBVEV-UHFFFAOYSA-N 0.000 description 1
- RVTZCBVAJQQJTK-UHFFFAOYSA-N oxygen(2-);zirconium(4+) Chemical compound [O-2].[O-2].[Zr+4] RVTZCBVAJQQJTK-UHFFFAOYSA-N 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 239000003961 penetration enhancing agent Substances 0.000 description 1
- WXZMFSXDPGVJKK-UHFFFAOYSA-N pentaerythritol Chemical class OCC(CO)(CO)CO WXZMFSXDPGVJKK-UHFFFAOYSA-N 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- 239000004014 plasticizer Substances 0.000 description 1
- 239000004584 polyacrylic acid Substances 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 150000008442 polyphenolic compounds Chemical class 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 1
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 description 1
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 1
- XEYBRNLFEZDVAW-UHFFFAOYSA-N prostaglandin E2 Natural products CCCCCC(O)C=CC1C(O)CC(=O)C1CC=CCCCC(O)=O XEYBRNLFEZDVAW-UHFFFAOYSA-N 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 239000002516 radical scavenger Substances 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 239000012088 reference solution Substances 0.000 description 1
- 239000003507 refrigerant Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 210000000582 semen Anatomy 0.000 description 1
- 239000012056 semi-solid material Substances 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 206010040872 skin infection Diseases 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 1
- LUPNKHXLFSSUGS-UHFFFAOYSA-M sodium;2,2-dichloroacetate Chemical compound [Na+].[O-]C(=O)C(Cl)Cl LUPNKHXLFSSUGS-UHFFFAOYSA-M 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 235000013599 spices Nutrition 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 229910052712 strontium Inorganic materials 0.000 description 1
- CIOAGBVUUVVLOB-UHFFFAOYSA-N strontium atom Chemical compound [Sr] CIOAGBVUUVVLOB-UHFFFAOYSA-N 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 230000000475 sunscreen effect Effects 0.000 description 1
- 239000000516 sunscreening agent Substances 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 235000019605 sweet taste sensations Nutrition 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- 229920001059 synthetic polymer Polymers 0.000 description 1
- 235000010384 tocopherol Nutrition 0.000 description 1
- 229960001295 tocopherol Drugs 0.000 description 1
- 229930003799 tocopherol Natural products 0.000 description 1
- 239000011732 tocopherol Substances 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 238000002834 transmittance Methods 0.000 description 1
- IMFACGCPASFAPR-UHFFFAOYSA-N tributylamine Chemical compound CCCCN(CCCC)CCCC IMFACGCPASFAPR-UHFFFAOYSA-N 0.000 description 1
- LADGBHLMCUINGV-UHFFFAOYSA-N tricaprin Chemical class CCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCC)COC(=O)CCCCCCCCC LADGBHLMCUINGV-UHFFFAOYSA-N 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
- LINXHFKHZLOLEI-UHFFFAOYSA-N trimethyl-[phenyl-bis(trimethylsilyloxy)silyl]oxysilane Chemical compound C[Si](C)(C)O[Si](O[Si](C)(C)C)(O[Si](C)(C)C)C1=CC=CC=C1 LINXHFKHZLOLEI-UHFFFAOYSA-N 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 229940099259 vaseline Drugs 0.000 description 1
- 239000004034 viscosity adjusting agent Substances 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 239000007762 w/o emulsion Substances 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 239000011787 zinc oxide Substances 0.000 description 1
- XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical compound [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 description 1
- 229910001928 zirconium oxide Inorganic materials 0.000 description 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
Abstract
The invention provides a kind of mangosteen extract and application thereof, described mangosteen extract has good whitening and antidotal effect, can be used for cosmetics, health food and field of medicaments, especially can be applicable in cosmetics.
Description
Technical field
The invention belongs to field of natural product chemistry, particularly relate to a kind of mangosteen extract and application thereof.
Background technology
Garcinia mangostana (Garciniamangostana) is a kind of fruit originating in tropical and subtropical zone, has very high nutritive value, has another name called mangosteen, Manggis, Cortex Garciniae, originates in torrid areas, Nan Yang, has the title of " after the fruit of the torrid zone ".The areas such as Taiwan of China, Guangdong, Fujian and Yunnan also more introduces a fine variety, and people are called " after in fruit " and " God really ".Why Garcinia mangostana is called " torrid zone fruit after ", and except itself has a sweet taste, another main cause is the role taken in the medicine of ancient times Southeast Asia, and traditionally, Garcinia mangostana is used for controlling the temperature of fever by people and prevents various skin infection.The peel of Garcinia mangostana or crust all contain abundant Xanthone, help enhancement immune system health, and it is happy to make us body and mind.
Garcinia mangostana is nutritious, the sweet middle band acid of taste, delicious abnormal, is rich in flavonoid, polyphenol, protein and lipid.Traditional medicine thinks that its sarcocarp is cold in nature, has refrigerant antipyretic effect, cures mainly thirsty xerostomia, burn, scald, eczema etc.All the time, Garcinia mangostana is in the plant amedica of tropical and subtropical region Chang Zuowei antiinflammatory, and oral administration, also can use in external application, but excessive use can to the toxic effect of mitochondrial function, and infringement Repiration, causes lactic acidosis.
In peel of Carcinia mangostana L., the extraction ratio of volatile oil is 0.14%, identifies 22 kinds of chemical substances, accounts for 92.68% of total composition; In sarcocarp, the extraction ratio of volatile oil is 0.21%, identifies 11 kinds of chemical substances, accounts for 69.11% of total composition.Main containing alkene class, naphthalene class and acids in peel of Carcinia mangostana L. volatile oil, main containing alcohols, alkene class and alkanes in sarcocarp volatile oil; Peel and sarcocarp main constituent are α cadinene, and content is respectively 32.41% and 41.38%.Research shows, mangosteen extract has good antiphlogistic effects, and causing scorching medium to histamine, 5-hydroxy tryptamine and dinoprostone etc. all has good inhibitory action.Simultaneously, mangosteen extract has stronger inhibitory action to the multiple pathogenic microorganism of nature, mangosteen extract can suppress dermatology common disease bacterium as the growth of staphylococcus aureus, some of them composition is still inhibited to methicillin resistant staphylococcus aureus, wherein especially the strongest with α-mangostin activity.But, have not yet to see relevant in Garcinia mangostana in beauty and skin care, the investigation and application of especially whitening aspect.
Summary of the invention
The object of the invention is to: a kind of mangosteen extract and application thereof are provided, be intended to the activity extract in Garcinia mangostana to be applied in skin preparations for extenal use, to play the effect of beauty and skin care.
The object of the present invention is achieved like this:
A kind of mangosteen extract, its infrared spectrum is at 3400cm
-1left and right is the characteristic absorption peak of hydroxyl, 3000-2850cm
-1region is C-H stretching vibration characteristic absorption peak, 1600cm
-1left and right is the characteristic absorption peak of phenyl ring, 1300-1000cm
-1for C-O stretching vibration characteristic absorption peak.
A kind of mangosteen extract, its general flavone content is 1-34%.
By Garcinia mangostana raw material being flooded organic solvent and carrying out after extraction filtering, reducing pressure and concentrated rear acquisition Garcinia mangostana crude extract; By Garcinia mangostana crude extract again through adsorbent resin absorption and the eluting of organic solvent, after evaporate to dryness Garcinia mangostana activity enrichment extract, Garcinia mangostana crude extract and activity enrichment extract are carried out respectively the experimentation of anti-aging effects and whitening function.
Described organic solvent refers to the organic solvent containing hydroxyl or carbonyl isopolarity group, such as but not limited to: water, Methanamide, dimethyl formamide, triethylamine, tri-n-butylamine, acetonitrile, methyl formate, ethyl acetate, DMC dimethyl carbonate, dimethyl sulfoxine, acetone, butanone, dioxane, pyridine, oxolane, methanol, ethanol, acetate fiber, chloroform, glycerol, propylene glycol, propylene glycol, isopropyl alcohol, n-butyl alcohol and ether etc., in one or more, wherein preferred alcohol aqueous solution.
When taking ethanol water as organic solvent, the concentration of ethanol selects 0-95%, and preferably 70%.
Described adsorbent resin and macroporous adsorbent resin, prioritizing selection low pole or the adsorbent resin of middle polarity, such as: X-5, AB-8, D101, XDA-6, LX-21, NK-9, D3520 and WLD etc., wherein preferred AB-8 resin, AB-8 is polystyrene type nonpolar adsorption resin, there is certain ester group on surface, is hydrophobic adsorption.The specific surface area of this resin and aperture are comparatively large, are suitable for that absorption is all kinds of has certain hydrophobic composition, and adsorbance is comparatively large, and eluting is easy, and adsorption dynamics adsorption kinetics is functional.Stablize the acid under heat, organic solvent and average operating, alkali, therefore service life is longer.Albumen, saccharide, mineral acid, alkali, salt, micromolecule hydrophilic organics hydrophilicity are not all adsorbed, thus reaches separation object.
Known according to test, mangosteen extract all has good effect in whitening and defying age, can add in cosmetic formulations as active component, and the active component of indication can provide one or more effect in some cases here.
Active component described in the present invention can also be pantothenylol, glycyrrhizic acid dipotassium, allantoin, nicotiamide, NAP, Herba Violae Hortensis extract, hyaluronate sodium, tocopherol acetas, undecylenoyl phenylalanine etc.In addition, this type of describes is for the ease of understanding, and is not the application or listed application that composition are limited to specifically note.
Mangosteen extract can be applicable to skin preparations for extenal use, health food and medicine, especially can be applicable in cosmetics, the consumption different according to the dissimilar interpolation of preparation.
Described Dermatologic preparation composition is the general designation concept of all the components being generally used for skin outside, such as, can be cosmetic combination or pharmaceutical compositions.Can be foundation make up material, facial dressing cosmetic preparation, health cosmetic preparation etc. in described cosmetic combination, to its dosage form without particular restriction, can choose reasonable according to different object.
According to the medium difference also allowed containing different cosmeceutical aspects of dosage form and object or matrix excipients in described cosmetic combination.
May be used for the cosmetics of Dermatologic preparation composition of the present invention, dermatological or pharmaceutically acceptable excipient and include, but are not limited to one or more aqueous systems, glycerol, C1-4 alcohols, aliphatic alcohols, fatty ethers, fatty lipid, polyalcohols, di-alcohols, vegetable oil, mineral oil, liposome, lamella lipid material, silicone oil, water or its combination in any.
In the present invention, excipient can be the form of aqueous phase, oil phase, gel, water bag wax pattern emulsion, emulsion oil-in-water or water-in-oil emulsion.Aqueous phase is the mixture of one or more water solublity or dispersibility component, and it can be liquid, semisolid or solid under room temperature (25 DEG C).It can be maybe the form of suspension, dispersion liquid or the solution in water or water-ol excipient that excipient comprises, and it can contain thickening agent or gel.The product form that the knowledge-chosen that those skilled in the art can grasp based on those skilled in the art is suitable, the component wherein comprised.
Described compositions can comprise aqueous phase, this aqueous phase can contain the mixture of water or water and at least one hydrophilic organic solvent, described hydrophilic organic solvent such as alcohol, the straight or branched low-grade monobasic alcohol especially containing 2-5 carbon atom, as ethanol or propanol; Polyhydric alcohol, as propylene glycol, sorbitol, glycerol, pantothenylol or Polyethylene Glycol and composition thereof.
When the compositions of inventing is emulsion form, said composition optionally can also comprise surfactant.
Described compositions can also comprise film forming polymer, as polyurethanes, polyacrylic acid homopolymer or copolymer, polyester, based on the resin of hydrocarbon and/or silicone resin.Polymer can be dissolved in or to be scattered in the acceptable excipient of cosmetics and optional and plasticizer merges.
Compositions of the present invention can also comprise oil phase, and described oil phase to contain under room temperature (25 DEG C) for the oil-soluble of liquid or oil-dispersing property component and/or is at room temperature oily or wax-like material, as wax, semisolid, natural gum and composition thereof.This oil phase can also contain organic solvent.
Usually be at room temperature liquid, suitable oily matter comprises: the oil based on hydrocarbon deriving from animal, as perhydro-squalene; Based on the vegetable oil of hydrocarbon, as the triglyceride of the C4-10 fatty acid of liquid, such as enanthic acid or Trivent OCG class, or oil, such as Oleum helianthi, Semen Maydis oil, soybean oil, Oleum Vitis viniferae, Oleum Ricini, American Avocado Tree oil, caprylic/capric triglyceride class, Jojoba oil; The straight or branched hydro carbons in mineral or synthesis source, such as liquid paraffin and its derivant, vaseline; The esters of synthesizing ester and ethers, particularly fatty alcohol, such as isopropyl myristate, Palmic acid 2-Octyl Nitrite, stearic acid 2-octyldodecyl, isostearyl isostearate ester; Hydroxylating esters, the enanthic acid esters of such as lactic acid isooctadecanol ester, octyl hydroxystearate, octyl hydroxystearate, hydroxy stearic acid octyldodecyl, fatty alcohol, sad esters and capric acid lipid; Polyhydric alcohol esters, such as propylene, neopentyl glycol two heptanoate, the different pelargonate of diethylene glycol two and pentaerythritol esters; Aliphatic alcohols containing C12-26, such as octyldodecanol, 2-butyl capryl alcohol, 2-hexyldecanol, 2-undecylpentadecanol, oleyl alcohol; Based on fluorocarbon oil and/or the fluorosilicon oil of part hydrocarbon, silicone oil, be at room temperature liquid or semisolid volatility or nonvolatile straight chain or cyclo-methicone, such as annular dimethyl polysiloxane and polydimethylsiloxane, it optionally comprises phenyl, such as Silicone DC 556, siloxanes and composition thereof.
Compositions of the present invention can comprise any component be usually used in cosmetic field further.These components comprise antiseptic, water phase thickener (polysaccharide biopolymer, synthetic polymer) and fatty phase thickening agent, aromatic, hydrophilic and lipophilic active agent and composition thereof.
Compositions of the present invention can also comprise other Particle Phase, and described Particle Phase can be the pigment and/or pearling agent and/or filler that use in cosmetic composition.
Pigment may reside in compositions, and suitable inorganic pigment comprises titanium oxide, zirconium oxide and cerium oxide and zinc oxide, ferrum oxide and ferrum are blue; Suitable organic pigment comprises barium, strontium, calcium and aluminum color lake and carbon black.
Pearling agent may reside in compositions, and suitable pearling agent comprises the Muscovitum being coated with titanium oxide, ferrum oxide or natural pigment.
Filler may reside in compositions, suitable filler comprises Pulvis Talci, silicon dioxide, zinc stearate, Muscovitum, Kaolin, nylon powder, polyethylene powders, Teflon, starch, borazon, copolymer microsphere, such as silicone resin microballon.
The oil phase of the present composition can comprise one or more waxes, natural gum or its mixture.Wax comprises based on the wax of hydrocarbon, fluorine wax and/or siloxane wax, and can derive from plant, mineral, animal and/or synthesis source.Suitable wax comprises Cera Flava, Brazil wax, candelilla wax, paraffin, microwax, ceresine; Synthetic wax comprises Tissuemat E, siloxane wax containing C16-45.Natural gum is generally polydimethylsiloxane or sodium carboxymethyl cellulose or polysaccharide, and semi-solid material is generally the compound based on hydrocarbon, as lanoline and derivant thereof.
Compositions of the present invention can be mixed with any suitable product form.This kind of product form includes, but are not limited to aerosol spray, cream, emulsion, solid, liquid, dispersion, foam, gel, astringent, mousse, ointment, powder, patch, brilliantine, solution, hands by pump-type spray, club, facial film and wet paper towel.Can using compositions of the present invention by various method well-known in the art expediently for the preparation of or as cosmetics, dermatological or medicine local application product.
Dermatologic preparation composition of the present invention can comprise one or more following ingredients: anti-allergic agent, antimicrobial, antioxidant, chelating agen, coloring agent depigmentation, emollient, emulsifying agent, exfoliation agent, film former, spice, wetting agent, insect repellent, lubricant, pharmaceutically active agents, humidizer, photostabilizer, antiseptic, skin protectant, skin penetration enhancer, sunscreen, stabilizing agent, surfactant, thickening agent, viscosity modifier, vitamin or its combination in any.
Accompanying drawing explanation
Fig. 1 is the infrared spectrogram of Garcinia mangostana 70% alcohol elution that the embodiment of the present invention provides.
Detailed description of the invention
In order to make object of the present invention, technical scheme and advantage clearly understand, below in conjunction with drawings and Examples, the present invention is further elaborated.Should be appreciated that specific embodiment described herein only in order to explain the present invention, be not intended to limit the present invention.
Embodiment 1: the concentration of Extraction solvent (ethanol) is chosen
Get the powder 20g after mangosteen drying and crushing, with pure water 200ml merceration, supersound extraction 2 times under room temperature, each 30min (500W), gets filtrate merging, and decompression and solvent recovery, to dry, got extract appropriate, is mixed with 0.05mg/ml solution for standby.
Getting the powder 20g after mangosteen drying and crushing, is 30% ethanol 200ml merceration, supersound extraction 2 times with volumetric concentration under room temperature, each 30min (500W), get filtrate merging, decompression and solvent recovery, to dry, got extract appropriate, is mixed with 0.05mg/ml solution for standby.
Getting the powder 20g after mangosteen drying and crushing, is 70% ethanol 200ml merceration, supersound extraction 2 times with volumetric concentration under room temperature, each 30min (500W), get filtrate merging, decompression and solvent recovery, to dry, got extract appropriate, is mixed with 0.05mg/ml solution for standby.
Getting the powder 20g after mangosteen drying and crushing, is 95% ethanol 200ml merceration, supersound extraction 2 times with volumetric concentration under room temperature, each 30min (500W), get filtrate merging, decompression and solvent recovery, to dry, got extract appropriate, is mixed with 0.05mg/ml solution for standby.
Above-mentioned 4 kinds of solution prepared are carried out respectively the test of free radical scavenging effect.
Test principle: have single electron according to DPPH free radical, the last one is had to absorb at 517nm place, its alcoholic solution is the characteristic of purple, when there being free radical scavenger to exist, make it absorb owing to matching with its single electron to fade away, its fading extent becomes quantitative relationship with the electron amount of its acceptance, thus can carry out quantitative study fast with spectrophotometer, detect free radical scavenging situation, thus whether judgement sample has oxidation resistance.
Test method: the testing sample solution 2ml of different dilution factor, different ratio is added in test tube, then add 2ml76 μm of ol/LDPPH alcoholic solution, mixing, under room temperature, lucifuge is at dark place reaction 30min.Absorbance A bs is measured at 525nm place.Each concentration in triplicate, is averaged as fitting data, to ensure the accuracy of experimental result.
Clearance rate I (%)=[1-(T-T0)/(C-C0)] × 100%
In formula: T0:2ml water or DMSO add the absorbance of 2mlDPPH solution;
T:2ml sample liquid adds the absorbance of 2mlDPPH solution;
C0:2ml water or DMSO add the absorbance of 2ml95% ethanol;
C:2ml sample liquid adds the absorbance of 2ml95% ethanol.
According to formulae discovery clearance rate above.Result of the test is as shown in table 1:
Table 1
As seen from the above table, when the ethanol of employing 70% volumetric concentration is Extraction solvent, the Free-radical scavenging activity of mangosteen extract is best.
Embodiment 2: choosing of solid-liquid ratio:
Getting the powder 20g after mangosteen drying and crushing, is 70% ethanol 160ml merceration, supersound extraction 2 times with volumetric concentration under room temperature, each 30min (500W), get filtrate merging, decompression and solvent recovery, to dry, got extract appropriate, is mixed with 0.05mg/ml solution for standby.
Getting the powder 20g after mangosteen drying and crushing, is 70% ethanol 200ml merceration, supersound extraction 2 times with volumetric concentration under room temperature, each 30min (500W), get filtrate merging, decompression and solvent recovery, to dry, got extract appropriate, is mixed with 0.05mg/ml solution for standby.
Getting the powder 20g after mangosteen drying and crushing, is 70% ethanol 240ml merceration, supersound extraction 2 times with volumetric concentration under room temperature, each 30min (500W), get filtrate merging, decompression and solvent recovery, to dry, got extract appropriate, is mixed with 0.05mg/ml solution for standby.
Getting the powder 20g after mangosteen drying and crushing, is 70% ethanol 300ml merceration, supersound extraction 2 times with volumetric concentration under room temperature, each 30min (500W), get filtrate merging, decompression and solvent recovery, to dry, got extract appropriate, is mixed with 0.05mg/ml solution for standby.
Above-mentioned 4 kinds of solution prepared are carried out respectively the test of free radical scavenging effect, test method is the same.Result of the test is as shown in table 2:
Table 2
As seen from the above table, when the ethanol of employing 70% volumetric concentration is Extraction solvent and solid-liquid ratio is 1: 10, the Free-radical scavenging activity of mangosteen extract is best.
Embodiment 3: the preparation of mangosteen extract
The preparation of Garcinia mangostana crude extract: get the powder 20g after mangosteen drying and crushing is 70% ethanol 200ml merceration, supersound extraction 2 times with volumetric concentration under room temperature, each 30min (500W), get filtrate merging, decompression and solvent recovery, to dry, obtains Garcinia mangostana crude extract, for efficacy study.
The preparation of Garcinia mangostana activity enrichment extract: get the powder 100g after mangosteen drying and crushing, with 70% ethanol 1000ml merceration under room temperature, supersound extraction 2 times, each 30min (500W), filtrate merges (about 1800ml), decompression and solvent recovery is extremely without alcohol taste, cross AB-8 resin, successively with 30% ethanol, 50% ethanol and 70% ethanol elution, collect each stream part (respectively about 400ml) respectively, evaporate to dryness, obtain Garcinia mangostana 30% alcohol elution (2.07g) respectively, Garcinia mangostana 50% alcohol elution (1.24g) and Garcinia mangostana 70% alcohol elution (0.53g), for efficacy study.
Embodiment 4: the free radical scavenging Effect study of mangosteen extract
The crude extract of the Garcinia mangostana of preparation, 30% alcohol elution, 50% alcohol elution and 70% alcohol elution are carried out respectively the test of free radical scavenging effect, test method is the same.Result of the test is as shown in table 3:
Table 3
As seen from the above table, the various extracts of Garcinia mangostana all have the effect of good scavenging free radicals to free radical, and especially the scavenging action of 70% alcohol elution to free radical is best.
Embodiment 5: the Elastase Inhibitory research of mangosteen extract
Test method is according to document (Am.J.Pharmacol.Toxicol., 2009,4, method 127-129) is carried out, step is: in 96 orifice plates, add the 0.1MTris-Cl buffer solution (PH=8.0) that 10uL sample solution and 130uL contain 1.015mM reaction substrate Succ-Ala-Ala-Ala-p-nitroanilide, incubation 5 minutes at 25 DEG C, add 15uL elastin laminin enzymatic solution (0.5U/ml), continue incubation 30min at 25 DEG C, then measure the absorbance of 410nm wavelength by microplate reader.Replace sample aqueous solution with deionized water, as reference solution, measure absorbance, by with matched group compare the relative inhibition obtaining sample sets.Result of the test is in table 4:
Table 4
As seen from the above table, the various extracts of Garcinia mangostana all have good inhibitory action to elastoser, and especially the inhibitory action of 70% alcohol elution to elastoser is best.
Embodiment 6: the tyrosinase inhibitory action research of mangosteen extract
Test method: the sample solution respectively adding 1ml variable concentrations in sample cell and sample controls pipe, positive and negative control pipe replaces with phosphate buffer.0.5ml tyrosinase solution (Mei Huo unit 125u/ml) is added in sample cell and positive control pipe, sample controls and negative control pipe replace with 0.5ml phosphate buffer (pH=6.8), the all test tubes of jolting, sample and tryrosinase are fully mixed, 37 DEG C of tanks hatch 10 minutes, add the 0.03wt% tyrosine solution of 2ml, react 10 minutes, be namely engraved in 475nm place and measure absorbance.
Suppression ratio I (%)=[1-(T-T0)/(C-C0)] × 100%
In formula: T0: sample solvent contrasts;
T: sample controls;
C: positive control;
C0: positive control solvent control.
Result of the test is as shown in table 5:
Table 5
As seen from the above table, the various extracts of Garcinia mangostana all have good inhibitory action to tryrosinase, and especially the inhibitory action of 70% alcohol elution to tryrosinase is best.
Embodiment 7: the general flavone content of mangosteen extract detects
Pipette sample and rutin contrasts each 1mL in 10mL tool plug test tube, add the aluminum chloride/methanol solution of 1mL1%, by methanol constant volume, shake up, place 15min.With legal system for blank solution.Scan in 200 ~ 500nm wave-length coverage, record ultraviolet-visible absorption spectroscopy.The registration of sample maximum absorption band and rutin maximum absorption band is good, standard substance when therefore selecting rutin to be mensuration.Scanning result is shown in 355nm place and carries out determination of total flavonoids.Testing result is as shown in table 6:
Table 6
| Mangosteen extract | General flavone content (%) |
| Crude extract | 1 |
| 30% alcohol elution | 11 |
| 50% alcohol elution | 9 |
| 70% alcohol elution | 34 |
As seen from the above table, all containing certain total flavones in the various extracts of Garcinia mangostana, the general flavone content wherein in 70% alcohol elution is the highest.
Embodiment 8: the INFRARED ABSORPTION of mangosteen extract detects
Principle: when a branch of infrared light with continuous wavelength passes through material, in material molecule the frequency of vibration of certain group or rotational frequency the same with the frequency of infrared light time, molecule shakes the order transition of (turning) kinetic energy to higher (turning) kinetic energy level of shaking of energy with regard to absorbing energy by original ground state, the transition of vibration and rotational energy level occurs after molecule absorption infra-red radiation, and the light of this place's wavelength is just subsequently absorbed in the material.So infrared spectrometry is in fact a kind of analytical method determining material molecular structure and discriminating compound according to information such as the interatomic Relative Vibration of intramolecule and molecule rotation.The situation instrument record of molecule absorption infrared light is got off, just obtains infrared spectrogram.Infrared spectrogram leads to common wavelengths (λ) or wave number (σ) is abscissa, and representing the position of absworption peak, is vertical coordinate with light transmittance (T%) or absorbance (A), represents absorption intensity.
The infared spectrum of Garcinia mangostana 70% alcohol elution as shown in Figure 1.Known from collection of illustrative plates, the infrared spectrum of this mangosteen extract is at 3400cm
-1left and right is the characteristic absorption peak of hydroxyl, 3000-2850cm
-1region is C-H stretching vibration absworption peak, 1600cm
-1left and right is the characteristic absorption peak of phenyl ring, 1300-1000cm
-1for C-O stretching vibration absworption peak, illustrate that this extract contains phenolic hydroxyl group, phenyl ring etc.
By above various test, visible mangosteen extract has effect of good whitening, anti-ageing beauty and skin care of waiting for a long time.
Embodiment 9: the skin preparations for extenal use containing mangosteen extract
Get the powder 500g after mangosteen drying and crushing, with 70% ethanol 5000ml merceration, supersound extraction 2 times under room temperature, each 30min (500W), filtrate merges, decompression and solvent recovery, to without alcohol taste, crosses AB-8 resin, successively with the ethanol elution of variable concentrations, collect each eluting position, for the preparation of skin preparations for extenal use.The percentage by weight of described mangosteen extract in skin preparations for extenal use is 0.0001-4, preferred 0.01-2.It is below the embodiment of the embody rule of mangosteen extract in skin preparations for extenal use.In following table, "-" indicates without interpolation.
Embodiment 10: the astringent containing mangosteen extract
Get mangosteen extract, for the preparation of the astringent with defying age, whitening function, the component that described astringent contains is as shown in table 7:
Table 7
Embodiment 11: the essence containing mangosteen extract
Get mangosteen extract, for the preparation of the essence with defying age, whitening function, the component that described essence contains is as shown in table 8:
Table 8
Embodiment 12: the emulsion/frost containing mangosteen extract
Get mangosteen extract, for the preparation of the emulsion/frost with defying age, whitening function, the component that described emulsion/frost contains is as shown in table 9:
Table 9
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, all any amendments done within the spirit and principles in the present invention, equivalent replacement and improvement etc., all should be included within protection scope of the present invention.
Claims (1)
1. contain mangosteen extract as an essence for effective ingredient, it is characterized in that being made up of by weight percentage following composition:
Acrylic acid (ester) class/C10-30 alkyl acrylate cross-linked polymer PemulenTR-20.3
Aminomethyl propanol adjust ph is to 5.5-7
Essence appropriate amount of deionized water adds to 100
Wherein, mangosteen extract extracts by the following method: get the powder 20g after mangosteen drying and crushing, be 70% ethanol 200ml merceration, 500W supersound extraction 2 times with volumetric concentration under room temperature, each 30min, get filtrate merging, decompression and solvent recovery, to dry, obtains mangosteen extract, the general flavone content of described mangosteen extract is 34%, and the infrared spectrum of described mangosteen extract is at 3400cm
-1for the characteristic absorption peak of hydroxyl, 3000-2850cm
-1region is C-H stretching vibration absworption peak, 1600cm
-1for the characteristic absorption peak of phenyl ring, 1300-1000cm
-1for C-O stretching vibration absworption peak.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310340403.6A CN103393576B (en) | 2013-08-07 | 2013-08-07 | A kind of mangosteen extract and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310340403.6A CN103393576B (en) | 2013-08-07 | 2013-08-07 | A kind of mangosteen extract and application thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103393576A CN103393576A (en) | 2013-11-20 |
| CN103393576B true CN103393576B (en) | 2015-12-23 |
Family
ID=49557446
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310340403.6A Active CN103393576B (en) | 2013-08-07 | 2013-08-07 | A kind of mangosteen extract and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103393576B (en) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104721119A (en) * | 2015-03-03 | 2015-06-24 | 陈红旗 | Moisturizing hand cream |
| CN106137812A (en) * | 2015-04-03 | 2016-11-23 | 伽蓝（集团）股份有限公司 | Radix Gentianae extract and its production and use |
| CN106361784B (en) * | 2015-07-24 | 2020-08-14 | 山酮新药开发股份有限公司 | Use of mangosteen fruit shell extract for treating skin diseases |
| KR101721917B1 (en) * | 2015-09-21 | 2017-03-31 | 경상대학교산학협력단 | - Composition for skin whitening comprising -mangostin as effective component |
| CN105534812A (en) * | 2016-01-19 | 2016-05-04 | 中山百鸥医药科技有限公司 | Essence and preparation method thereof |
| CN105687032B (en) * | 2016-02-03 | 2018-05-11 | 湖南朗林生物制品有限公司 | A kind of natural composition for improving skin health |
| CN107648117A (en) * | 2017-10-31 | 2018-02-02 | 广州赛莱拉干细胞科技股份有限公司 | A kind of whitening spot-removing skin care item and preparation method thereof |
| TWI754345B (en) * | 2019-08-27 | 2022-02-01 | 大江生醫股份有限公司 | Use of garcinia mangostana fermented liquid for preparing a composition for beautifying skin and/or reducing fat |
| CN111357909A (en) * | 2020-04-02 | 2020-07-03 | 吉林农业科技学院 | Purification process and determination experimental method of mangosteen polysaccharide hypoglycemic solid beverage |
| CN111568845A (en) * | 2020-07-02 | 2020-08-25 | 成都恩喜医疗管理有限公司 | Nutrient solution for delaying facial aging |
Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2754447A1 (en) * | 1996-10-16 | 1998-04-17 | Codif International Sa | Sun-cream preparation |
| JP2000229857A (en) * | 1999-02-12 | 2000-08-22 | Eag Kk | Testosterone-5-alpha-reductase inhibitor |
| US20060105069A1 (en) * | 2004-11-16 | 2006-05-18 | Alex Moffett | Pharmaceutical and therapeutic compositions derived from Garcinia mangostana L plant |
| WO2007002666A2 (en) * | 2005-06-22 | 2007-01-04 | Renaissance Herbs, Inc. | Pharmaceutical and therapeutic compostions derived from garcinia mangostana l plant |
| CN101428046A (en) * | 2007-11-06 | 2009-05-13 | 王莉 | Novel broad spectrum antiphlogistic pain-easing externally used medicament |
| CN101904880A (en) * | 2010-07-20 | 2010-12-08 | 暨南大学 | Mangosteen total xanthone extract and application thereof in preparation of TR3 receptor inducer |
| CN102241658A (en) * | 2011-05-06 | 2011-11-16 | 南京泽朗医药科技有限公司 | Method for purifying gamma-mangostin by using high-speed countercurrent chromatography |
| CN102365090A (en) * | 2009-03-31 | 2012-02-29 | 罗蒂株式会社 | Composition for treatment and/or prevention of dermatopathy |
| CN103211850A (en) * | 2013-04-23 | 2013-07-24 | 吉林化工学院 | Method for extracting flavone from mangosteen skin |
-
2013
- 2013-08-07 CN CN201310340403.6A patent/CN103393576B/en active Active
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2754447A1 (en) * | 1996-10-16 | 1998-04-17 | Codif International Sa | Sun-cream preparation |
| JP2000229857A (en) * | 1999-02-12 | 2000-08-22 | Eag Kk | Testosterone-5-alpha-reductase inhibitor |
| US20060105069A1 (en) * | 2004-11-16 | 2006-05-18 | Alex Moffett | Pharmaceutical and therapeutic compositions derived from Garcinia mangostana L plant |
| WO2007002666A2 (en) * | 2005-06-22 | 2007-01-04 | Renaissance Herbs, Inc. | Pharmaceutical and therapeutic compostions derived from garcinia mangostana l plant |
| CN101428046A (en) * | 2007-11-06 | 2009-05-13 | 王莉 | Novel broad spectrum antiphlogistic pain-easing externally used medicament |
| CN102365090A (en) * | 2009-03-31 | 2012-02-29 | 罗蒂株式会社 | Composition for treatment and/or prevention of dermatopathy |
| CN101904880A (en) * | 2010-07-20 | 2010-12-08 | 暨南大学 | Mangosteen total xanthone extract and application thereof in preparation of TR3 receptor inducer |
| CN102241658A (en) * | 2011-05-06 | 2011-11-16 | 南京泽朗医药科技有限公司 | Method for purifying gamma-mangostin by using high-speed countercurrent chromatography |
| CN103211850A (en) * | 2013-04-23 | 2013-07-24 | 吉林化工学院 | Method for extracting flavone from mangosteen skin |
Non-Patent Citations (2)
| Title |
|---|
| 山竹果皮中抗氧化活性物质的提取分离;张泽生等;《食品研究与开发》;20090630;第30卷(第6期);第11-15页，尤其是第1.3.1节，1.3.6节，图4 * |
| 山竹黄酮的提取、合成、分析及性质研究;赵佳;《中国优秀硕士论文全文数据库 工程科技Ⅰ辑》;20080815(第8期);第31、33页，尤其是第31页第1段，第33页第2.2.1.2节 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103393576A (en) | 2013-11-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103393576B (en) | A kind of mangosteen extract and application thereof | |
| CN103393575B (en) | A kind of longan extract and application thereof | |
| CN107184482A (en) | Mateine and its application in skin preparations for extenal use | |
| CN104510668B (en) | Moisture-keeping composition and its preparation method and application | |
| CN107440949A (en) | Composition and its application comprising extractive of perilla and Radix Arnebiae extract | |
| CN103393578B (en) | A kind of carambola extract and application thereof | |
| ES2889777T3 (en) | Dahlia pinnata composition, Dahlia pinnata composition powder, cosmetic composition and production method thereof | |
| CN104758197B (en) | A kind of cudrania tricuspidata extract and its application | |
| CN104761651A (en) | Motherwort polysaccharide and application thereof | |
| CN105310918A (en) | Green bonnie flower extract and applications thereof | |
| CN103393577B (en) | A kind of Dermatologic preparation composition containing fruit extract mixture | |
| CN105213290A (en) | A kind of Volvariella volvacea (Bull． Ex Franch.) Singer.extract and application thereof | |
| CN115957161A (en) | Skin cosmetic composition containing solubilized mangostin and application thereof | |
| CN104586697A (en) | Chickpea sprout extract and application thereof | |
| CN105106266B (en) | Leontopodium ruthenicum extract and application thereof | |
| CN105193680B (en) | Short Radix Sangusorbae extract and its application in cosmetics are prepared | |
| CN109966372A (en) | A kind of Cortex Lycii extract and its new opplication | |
| CN104558233B (en) | Chickpea sprout polysaccharide and application thereof | |
| CN104274352A (en) | Skin external preparation composition containing lycium ruthenicum extractive and blackcurrant extractive | |
| CN105267058A (en) | Scindapsus aureus flower and application | |
| ES2667751T3 (en) | Oily composition containing an extract of hemerocallis and its uses | |
| CN109966191B (en) | Chrysanthemum flower extract and new application thereof | |
| CN105267082A (en) | Impatiens balsamina extract and application thereof | |
| CN106620295B (en) | Chinese herbal medicine composition | |
| CN105250430A (en) | Rosa davurica pall extract and applications thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CP03 | Change of name, title or address |
Address after: 201403 Shanghai City, Fengxian District Lifenglu No. 12 Patentee after: Shanghai Natural Hall Group Co.,Ltd. Country or region after: China Address before: 200040 No. 12 Lifeng Road, Shanghai Patentee before: JALA Group Co. Country or region before: China |
|
| CP03 | Change of name, title or address |