CN103386041B - Honeysuckle, Chinese gall, realgar and dayflower cream for treating condyloma acuminata - Google Patents

Abstract

The invention relates to a traditional Chinese patent medicine preparation, and in particular relates to a honeysuckle, Chinese gall, realgar and dayflower cream for treating condyloma acuminata. The cream is characterized in that honeysuckle, Chinese gall, realgar powder, cattail pollen, dayflower, castor bean, reed rhizome, white pepper, puffball, semen strychni powder, centipede, radices trichosanthis, asarum, angelica root, perilla leaf, stiff silkworm, rhizoma alismatis and folium artemisiae argyi are adopted as traditional Chinese medicinal raw materials, wherein the cream is prepared by the following steps: packaging the realgar powder and the semen strychni powder independently for later use; shelling and crushing the castor bean; grinding the white pepper into fine powder, cutting the centipede and the stiff silkworm into pieces, putting the white pepper, the centipede and the stiff silkworm into warm sesame oil, and decocting with slow fire until the mixture is dried and turns into black; removing slag to obtain filtrate, adding the realgar powder and the semen strychni powder, and decocting with slow fire; adding white rice vinegar when the decoction is hot, uniformly mixing, filling into a large-caliber sterile glass bottle when the mixture is hot, and sealing the bottle cap for later use. Therefore, the honeysuckle, Chinese gall, realgar and dayflower cream is prepared, and has the advantages of clearing heat and removing toxicity and purging intense heat, diminishing swelling and draining purulence and promoting granulation, activating blood and dissolving stasis and relieving itching, softening hardness to dissipate stagnation and eliminating wart, strengthening body resistance and eliminating evil and strengthening consolidation, tonifying spleen and promoting diuresis and invigorating vital energy and the like.

Description

Silver times Dendrobium denneanum Kerr. cream for condyloma acuminatum

Technical field

The present invention relates to a kind of Chinese patent medicine preparation, specifically a kind of silver for condyloma acuminatum times Dendrobium denneanum Kerr. cream.

Background technology

Condyloma acuminatum is the sexually transmitted disease (STD) being caused by human papillomavirus, often occurs in the positions such as anus and external genitalia, and main trafficability characteristic contact direct contagion, is modal sexually transmitted disease (STD) in global range.In recent years the pathogenic effects that condyloma acuminatum occurs at anus anogenital cancer has been affirmed fully in lot of documents report and basic clinical research, as is most commonly in cervical cancer high-risk-type etc.The young and the middle aged that being apt to occur in property of primary disease is active, is generally 2 weeks incubation period～8 months, average out to 3 months.External genitalia and skin around the rectum mucosa humid region are predilection site, and male is more common in coronary sulcus, foreskin, glans penis, frenulum, urethral orifice, body of penis, perineum etc.Women is more common in the positions such as large nympha, urethral orifice, clitoris, vagina, cervix uteri, perineum and crissum.Skin lesion is from the beginning of being the little pimple of the single or multiple pale reds that are dispersed in, and quality is soft, and top is sharp-pointed, and rear cumulative increase, can be mamillary, cauliflower form, cockscomb shape etc. more.Wart body is often white in color, pink or dirty Lycoperdon polymorphum Vitt, and surface easily occurs rotten to the corn, has sepage, dipping and ulceration, still can merge hemorrhage and infection.Clinical diagnosis is the patient of condyloma acuminatum, mainly gives laser, freezing, the method such as fulgerize is removed wart body, and huge wart body can excision, also has the treatments such as the interferon of cooperation, not only expensive, and easily recurrence.The western fourth of application podophyllotoxin, podophyllum ester tincture have teratogenesis, and chloroacetic acid liquid normal tissue is also corrosive, all easily recurrence.Because condyloma acuminatum is viral infection, people is unique host of papovavirus, and virus is under mucocutaneous, thereby physiotherapy is removed wart precursor virus and is easy to recurrence.

Summary of the invention

Technical problem to be solved by this invention is in order to overcome the deficiencies in the prior art, provide that a kind of cost is low, treatment condyloma acuminatum curative effect is high, have no side effect and do not recur, have heat-clearing and toxic substances removing pathogenic fire purging, detumescence and apocenosis granulation promoting, blood circulation promoting and blood stasis dispelling is antipruritic, the hard masses softening and resolving wart that disappears, strengthening vital QI to eliminate pathogenic factors consolidates, the silver for condyloma acuminatum of invigorating spleen to remove dampness QI invigorating effect times Dendrobium denneanum Kerr. cream.

The technical scheme that the present invention solves the problems of the technologies described above employing is:

A kind of silver for condyloma acuminatum times Dendrobium denneanum Kerr. cream, it is characterized in that adopting Flos Lonicerae, Galla Chinensis, Realgar powder, Pollen Typhae, Herba Commelinae, Semen Ricini, Rhizoma Phragmitis, Radix orixae japonicae, Lasiosphaera Seu Calvatia, Semen Strychni Pulveratum, Scolopendra, Radix Trichosanthis, Herba Asari, the Radix Angelicae Dahuricae, Folium Perillae, Bombyx Batryticatus, Rhizoma Alismatis, Folium Artemisiae Argyi is crude drug, first by Realgar powder, stand-by after Semen Strychni Pulveratum list bag, Semen Ricini shells and smashs to pieces, Radix orixae japonicae is ground into fine powder, Scolopendra, Bombyx Batryticatus is cut into segment, join in warm Oleum sesami, 6 milliliters of the crude drug of 1 gram of Chinese medicine can add Oleum sesami, slow fire decocts 30～40 minutes, medicinal residues are decocted to withered black, the filtrate of removing slag to obtain, add again Realgar powder, Semen Strychni Pulveratum slow fire decocts 3～5 minutes, add while hot white rice vinegar, in the crude drug of 1 gram of Chinese medicine, can add 1 milliliter of white rice vinegar, and mix homogeneously, pack into while hot in large mouthful of aseptic vial, seal bottle cap is standby, make silver times Dendrobium denneanum Kerr. cream.

The crude drug of above-mentioned Chinese medicine of the present invention is by weight percentage: Flos Lonicerae 12～15%, Galla Chinensis 4～7%, Realgar powder 0.8～1.5%, Pollen Typhae 6～8%, Herba Commelinae 8～11%, Semen Ricini 2～4%, Rhizoma Phragmitis 5～8%, Radix orixae japonicae 3～5%, Lasiosphaera Seu Calvatia 2～4%, Semen Strychni Pulveratum 2～3%, Scolopendra 5～8%, Radix Trichosanthis 6～8%, Herba Asari 1～2.5%, the Radix Angelicae Dahuricae 3～5%, Folium Perillae 4～6%, Bombyx Batryticatus 3～6%, Rhizoma Alismatis 4～7%, Folium Artemisiae Argyi 2～3%.

The invention has the beneficial effects as follows that cost is low; treatment condyloma acuminatum curative effect is high, have no side effect; can infiltrate fast wart body bottom and surrounding skin internal layer; kill the virus in epidermis, corium, mucomembranous cell core; and form potent protective layer at skin surface, prevent Virus entry, deep layer nourishes rough skin; excite body immunity, prevent recurrence.There is the effects such as heat-clearing and toxic substances removing pathogenic fire purging, detumescence and apocenosis granulation promoting, blood circulation promoting and blood stasis dispelling are antipruritic, hard masses softening and resolving disappears wart, strengthening vital QI to eliminate pathogenic factors consolidates, invigorating spleen to remove dampness QI invigorating, be applicable to male, women, have ansa and without ansa condyloma acuminatum.

one, the specific embodiment

Below in conjunction with embodiment, the invention will be further described:

Embodiment 1:

Adopting Flos Lonicerae, Galla Chinensis, Realgar powder, Pollen Typhae, Herba Commelinae, Semen Ricini, Rhizoma Phragmitis, Radix orixae japonicae, Lasiosphaera Seu Calvatia, Semen Strychni Pulveratum, Scolopendra, Radix Trichosanthis, Herba Asari, the Radix Angelicae Dahuricae, Folium Perillae, Bombyx Batryticatus, Rhizoma Alismatis, Folium Artemisiae Argyi is that raw material is prepared from.Every pair of its component (% by weight) is Flos Lonicerae 13.3, Galla Chinensis 5.9, Realgar powder 1.1, Pollen Typhae 7.8, Herba Commelinae 10.6, Semen Ricini 2.9, Rhizoma Phragmitis 6.9, Radix orixae japonicae 4.9, Lasiosphaera Seu Calvatia 2.9, Semen Strychni Pulveratum 2.9, Scolopendra 7.4, Radix Trichosanthis 7.4, Herba Asari 1.9, the Radix Angelicae Dahuricae 4.9, Folium Perillae 5.5, Bombyx Batryticatus 4.9, Rhizoma Alismatis 5.9, Folium Artemisiae Argyi 2.9.Getting above-mentioned 18 taste raw material gross weights is 204 grams, first by Realgar powder, after Semen Strychni Pulveratum list bag, use, the Semen Ricini of Yuing in 16 taste Chinese herbal medicine shells and smashs to pieces, Radix orixae japonicae is ground into fine powder, Scolopendra, Bombyx Batryticatus etc. are cut into segment, join in 1200 milliliters of warm Oleum sesami, slow fire decocts 30～40 minutes, medicinal residues are decocted to withered black, the filtrate of removing slag to obtain, add again Realgar powder, Semen Strychni Pulveratum slow fire decocts 3～5 minutes, add while hot 200 milliliters of white rice vinegars, mix homogeneously, pack into while hot in large mouthful of aseptic vial, approximately 800～1000 milliliters altogether, seal bottle cap is standby, make " silver times Dendrobium denneanum Kerr. cream ".Patients with condyloma acuminatum laser, freezing, the physical method such as fulgerize is removed after wart body or excision wart body, wound surface and surrounding edge add aseptic spatula with aseptic cotton carrier and coat silver times Dendrobium denneanum Kerr. cream, thick about 5mm, with Sterilized application, fix, each replacing before ointment, first use 30 grams of Folium Artemisiae Argyis, 30 grams of Rhizoma Phragmitiss, 10 grams of Radix orixae japonicaes add 1000 milliliters, water, intense fire boils, slow fire decocts and about 15 minutes, removes the moisture of approximately 200 milliliters, local with the stifling wart body of medicine juice of 800 milliliters while hot, with aseptic cotton carrier or gauze, dip the medicine juice of Wen Liang, clean coating wound surface, wait to do, repaste silver times Dendrobium denneanum Kerr. cream, method is the same, every day 2～3 times, with 5 days medicines, stopping 2 days is 1 course for the treatment of, be used in conjunction 4 courses for the treatment of.To the little pimple of the early stage pale red of condyloma acuminatum, after can first decocting with Folium Artemisiae Argyi, Rhizoma Phragmitis, Radix orixae japonicae (method is the same), with decocting stifling rear scouring of soup, repaste silver times Dendrobium denneanum Kerr. cream while hot, 2 days was 1 course for the treatment of, was used in conjunction 4 courses for the treatment of.Patient to recurrence can use said method again.

Principal agent of the present invention: Flos Lonicerae nature and flavor are sweet, tremble with fear, return lung, the heart, stomach warp, have heat-clearing and toxic substances removing, and dispelling wind and heat pathogens effect, for carbuncle furuncle, sore throat, erysipelas, toxic-heat and blood stasis, anemopyretic cold, epidemic febrile disease.Galla Chinensis can make the tissue protein of the parts such as skin, mucosa, ulcer solidify, and is astriction, can accelerate blood coagulation and is anastalsis, can precipitate alkaloid, has the alkaloid of solution intoxication.Staphylococcus aureus, Diplococcus pneumoniae, beta hemolytic streptococcus, typhoid fever, bacillus pyocyaneus, expense Shigella flexneri, hog cholera bacillus and escherichia coli are all had to inhibitory action.Galla Chinensis liquid through proposing with ether after its tannic acid still has antibacterial action, and its antibacterial action is mainly present in skin zone.Nature and flavor are sour, puckery, cold, return lung, large intestine, kidney channel.There is the pathogenic fire reducing of astringing the lung, relieving diarrhea with astringents, arresting sweating, hemostasis, removing dampness sore effect.For chronic cough of deficiency lung, lung-heat productive cough, chronic diarrhea chronic dysentery, spontaneous sweating, quench one's thirst, have blood in stool hemorrhoidal bleeding, traumatic hemorrhage, carbuncle sore tumefacting virus, Skin wet and rotten.Realgar powder is to common pyococcus, pathogenic entero becteria, and human-like, bacillus tuberculosis bovis, shame dirt bacillus and Common Pathogenic dermatophytes all have inhibitory action.Nature and flavor are pungent, warm, poisonous, return liver, large intestine channel.There is removing toxic substances parasite killing, removing dampness and eliminating phlegm, preventing the attack (or recurrence) of malaria effect, for carbuncle furuncle, snake bite and insect sting, abdominal pain due to worm stagnation, infantile convulsion, malaria.Pollen Typhae nature and flavor are sweet, flat, return liver, pericardium channel.There is hemostasis, blood stasis dispelling, treating stranguria effect, for haematemesis, epistaxis, spitting of blood, metrorrhagia, traumatic hemorrhage, amenorrhea dysmenorrhea, breast ventral spine pain, tumbling and swelling, blood strangury and dry pain.Herba Commelinae nature and flavor are sweet, light, cold, return lung, stomach, small intestine meridian.There is clearing away heat-fire, removing toxic substances, inducing diuresis to remove edema effect, for cold, fever, calentura excessive thirst, laryngopharynx swelling and pain, edema oliguria, the puckery pain of pyretic stranguria, carbuncle furunculosis.Semen Ricini nature and flavor are sweet, pungent, flat, poisonous, return large intestine, lung meridian.Have and rush down lower treating stranguria, detumescence and drawing out poison effect, for constipation due to dry stool, swollen ulcer drug, sore throat, scrofula.Rhizoma Phragmitis nature and flavor are sweet, cold, attach to the lung and stomach meridians.There is clearing away heat-fire, promoting the production of body fluid to quench thirst, relieving restlessness, preventing or arresting vomiting, diuresis effect, for calentura excessive thirst, cough due to lung-heat, lung abscess vomiting pus, gastric heat the vomit sound of vomiting, the puckery pain of pyretic stranguria.Radix orixae japonicae nature and flavor are pungent, hot, return stomach, large intestine channel.There is warming spleen and stomach for dispelling cold, the therapeutic method to keep the adverse QI flowing downwards, expectorant effect, for gastrofrigid vomiting.Stomachache is had loose bowels, inappetence, epilepsy abundant expectoration.Lasiosphaera Seu Calvatia nature and flavor are pungent, flat, return lung meridian.There is removing heat from the lung and relieving sorethroat, hemostasia effect, for the strongly fragrant lung pharyngalgia of wind heat, hoarseness, cough, external treatment epistaxis, wound hemorrhage.Semen Strychni Pulveratum nature and flavor are bitter, warm, very toxic, return liver, spleen channel.There is removing obstruction in the collateral to relieve pain, mass dissipating and swelling eliminating effect, for traumatic injury, fracture swell and ache, rheumatoid arthritis stubborn, paralysis and numbness, skin sore, laryngopharynx swelling and pain.Scolopendra nature and flavor are pungent, warm, poisonous, return Liver Channel.A extinguish wind town suffering, only strengthen the pain, tapping poison fights efficacy, used to move, twitching, infantile convulsion, the tuyere , hemiplegia, tetanus, rheumatism obstinate arlhralgia s headaches, ulcers, scrofula, snake insect bites.Sweet, the micro-hardship of Radix Trichosanthis nature and flavor, be slightly cold, attach to the lung and stomach meridians.There is clearing away heat-fire, promoting the production of body fluid to quench thirst, detumescence and apocenosis effect, for calentura excessive thirst, lung-heat type cough, interior-heat quench one's thirst, sore swollen toxin.Herba Asari nature and flavor are pungent, warm, GUIXIN, lung, kidney channel.There is expelling wind and cold, wind-expelling pain-stopping, sensible, warming the lung to resolve fluid-retention effect, for anemofrigid cold, headache, toothache, nasal obstruction watery nasal discharge, allergic rhinitis, nasal sinusitis, rheumatic arthralgia, phlegm retention, breath with cough.Radix Angelicae Dahuricae nature and flavor are pungent, warm, return stomach, large intestine, lung meridian.There is the cold expelling of inducing sweat, wind-expelling pain-stopping, a surname's clearing the nasal passage, dampness leukorrhagia stopping, detumescence and apocenosis effect, for headache due to common cold, supraorbital bone pain, nasal obstruction watery nasal discharge, allergic rhinitis, nasal sinusitis, toothache, leukorrhagia, skin infection, swell and ache.Folium Perillae nature and flavor are pungent, warm, return lung, spleen channel.There is the cold expelling of inducing sweat, relieving QI stagnancy in the stomach effect, poisoning for anemofrigid cold, cough vomiting and nausea, vomiting during pregnancy, fish Eriocheir sinensis.Bombyx Batryticatus nature and flavor are salty, pungent, flat, return liver, lung, stomach warp.Extinguish wind antispasmodic and functions of the pain, eliminating phlegm to fights efficacy, used to clamp phlegm, chronic ulcerated twitch, infantile urgent surprised, tetanus, in tuyere, wind hot headache, eye red sore throat itchy, rubella, hair h mumps.Rhizoma Alismatis nature and flavor are sweet, light cold, return kidney, urinary bladder channel.There is promoting diuresis to eliminate damp pathogen, expel the heat-evil, change turbid fat-reducing effect.For dysuria, edema distension, the oliguria of having loose bowels, dizziness due to fluid-retention, the puckery pain of pyretic stranguria, hyperlipemia.Folium Artemisiae Argyi nature and flavor acrid, bitter, warm, slightly poisonous, return liver,spleen,kidney warp.There is warming the meridian for stopping bleeding, dispersing cold for relieving pain effect, external removing dampness to relieve itching.For haematemesiss, blood nosebleed, metrorrhagia, menorrhagia, vaginal bleeding during pregnancy hematochezia, to lack abdomen cold type of pain, coldness and unbalance in meridians, cold womb infertile, external treatment skin pruritus.The ingenious prescription of 18 taste Chinese herbal medicine, science compatibility, existing theory of Chinese medical science foundation, has again the check of clinical practice.Mutual reinforcement between between medicine, mutual-assistance compatibility, can play synergism, can improve drug effect; Mutual restraint between two drugs, mutual-detoxication compatibility can alleviate or eliminate toxic and side effects.Chinese medicinal decoction takes advantage of hot smoking to wash wart body part or wound surface, by means of warm merit, dredge local QI and blood, strengthened the osmosis of medicine, in can inductor, produce a large amount of endogenous interferons, thorough copying of blocking virus, thus reach the object of rapid healing condyloma acuminatum, and effect is lasting, can effectively prevent that wart body from recurring again.In using the method treatment, avoid pungent, peppery irritable food, as tobacco and wine, Herba Alii fistulosi, Bulbus Allii, Fructus Capsici, Rhizoma Zingiberis Recens, seafood and beef or mutton etc., during treatment and prohibitive life in 6～8 months after curing.

The embodiment that each raw material of the present invention also can the listed ratio of according to the form below (percentage by weight) mixes realizes, and its processing technique is identical with embodiment 1.

Below in conjunction with clinical trial, the present invention is described in further detail:

1. case selection: from year October in June, 2009 to 2012, be selected from my Out-patient Department to be diagnosed as patients with condyloma acuminatum 67 examples, its diagnosis basis meets < < skin cypridology > > the 7th edition People's Health Publisher in 2008 and publishes " condyloma acuminatum " diagnostic criteria, male 41 examples in 67 examples, female's 26 examples; 23～57 years old age; The course of disease is the shortest 2 weeks, the longest 3 months; Skin lesion is mamillary 9 examples, and multiple skin lesion 36 examples of cauliflower form and cockscomb shape, are pimple sample skin lesion 22 examples; There are erosion, sepage 31 examples in surface.With laser, freezing, the physical method such as fulgerize, remove wart body 49 examples, early stage hillock rash sample skin lesion 18 examples are not removed wart body.

2. tcm diagnosis standard: the < < disease of tcm Standardization of diagnosis and curative effect > > that tcm diagnosis standard is promulgated with reference to State Administration of Traditional Chinese Medicine.

3. Therapeutic Method: laser for patients with condyloma acuminatum, freezing, the method such as fulgerize are removed after wart body, and wound surface and surrounding edge add aseptic spatula with aseptic cotton carrier and coat silver times Dendrobium denneanum Kerr. cream, and thick about 5mm, fixes with Sterilized application.Each replacing before ointment, first with 10 grams of 30 grams of Folium Artemisiae Argyis, 30 grams of Rhizoma Phragmitiss, Radix orixae japonicae, add 1000 milliliters, water, intense fire boils, slow fire decocted about 15 minutes, by the medicine juice of 800 milliliters, first stifling wart body is local while hot, dips medicine juice scouring coating wound surface again wait to do after Wen Liang with aseptic cotton carrier or gauze, repastes silver times Dendrobium denneanum Kerr. cream, method is the same, every day 2～3 times, with 5 days medicines, stopping 2 days is a course for the treatment of, is used in conjunction 4 courses for the treatment of.To the little pimple of the early stage pale red of condyloma acuminatum, after can first decocting with Folium Artemisiae Argyi, Rhizoma Phragmitis, Radix orixae japonicae (method is the same), while hot with decocting the stifling wart body region of soup, after Wen Liang, dipping medicine juice scouring wart body region again with aseptic cotton carrier or gauze waits to do, repaste silver times Dendrobium denneanum Kerr. cream, method is the same, every day 2～3 times, with 5 days medicines, stopping 2 days is a course for the treatment of, is used in conjunction 4 courses for the treatment of.Patient to recurrence can use said method again.

4. the standard of curative effect evaluation:

Cure: 4 courses for the treatment of of clinical treatment, wart body all disappears, and mucocutaneous recovery is normal, and transference cure is followed up a case by regular visits to after treatment 6 months, adopts phone or further consultation mode, within 6～8 months, does not recur, and acetic acid white test is all negative.

Effective: treat 4 courses for the treatment of, wart body substantially disappears and accounts for more than 90%, and mucocutaneous basic recovery is normal, and pain disappears substantially, further consultation in 3 months occasionally has recurrence, and acetic acid white test occasionally has the positive.

Effective: treat 4 courses for the treatment of, wart body 50% left and right of disappearing, mucocutaneously obviously changes, clinical symptom relief but still have pain, has recurrence in the time of 2 months, and acetic acid white test is most of positive.

Invalid: treat 4 courses for the treatment of, wart body does not disappear, mucocutaneous without changing, clinical symptoms is without disappearing, and still, acetic acid white test is all positive for pain.

Cure, effective, be effectively total effective rate.

5. therapeutic effect: use the present invention's 67 examples, application the standard of curative effect evaluation carries out treatment effectiveness evaluation: cure 46 examples, account for 68.7%; Effective 9 examples, account for 13.4%; Effective 7 examples, account for 10.4%; Invalid 5 examples, account for 7.5%; Total effective rate is 92.5%.

Claims (1)

1. for a silver times Dendrobium denneanum Kerr. cream for condyloma acuminatum, it is characterized in that adopting Flos Lonicerae, Galla Chinensis, Realgar powder, Pollen Typhae, Herba Commelinae, Semen Ricini, Rhizoma Phragmitis, Radix orixae japonicae, Lasiosphaera Seu Calvatia, Semen Strychni Pulveratum, Scolopendra, Radix Trichosanthis, Herba Asari, the Radix Angelicae Dahuricae, Folium Perillae, Bombyx Batryticatus, Rhizoma Alismatis, Folium Artemisiae Argyi is crude drug, first by Realgar powder, stand-by after Semen Strychni Pulveratum list bag, the Semen Ricini of remaininging in 16 taste Chinese herbal medicine shells and smashs to pieces, and Radix orixae japonicae is ground into fine powder, Scolopendra, Bombyx Batryticatus is cut into segment, joins in warm Oleum sesami, and the crude drug of 1 gram of Chinese medicine adds 6 milliliters of Oleum sesami, and slow fire decocts 30～40 minutes, and medicinal residues are decocted to withered black, the filtrate of removing slag to obtain, then add Realgar powder, Semen Strychni Pulveratum slow fire decocts 3～5 minutes, adds while hot white rice vinegar, adds 1 milliliter of white rice vinegar in the crude drug of 1 gram of Chinese medicine, and mix homogeneously, packing into while hot in large mouthful of aseptic vial, seal bottle cap is standby, make silver times Dendrobium denneanum Kerr. cream, the crude drug of described above-mentioned Chinese medicine is by weight percentage: Flos Lonicerae 12～15%, Galla Chinensis 4～7%, Realgar powder 0.8～1.5%, Pollen Typhae 6～8%, Herba Commelinae 8～11%, Semen Ricini 2～4%, Rhizoma Phragmitis 5～8%, Radix orixae japonicae 3～5%, Lasiosphaera Seu Calvatia 2～4%, Semen Strychni Pulveratum 2～3%, Scolopendra 5～8%, Radix Trichosanthis 6～8%, Herba Asari 1～2.5%, the Radix Angelicae Dahuricae 3～5%, Folium Perillae 4～6%, Bombyx Batryticatus 3～6%, Rhizoma Alismatis 4～7%, Folium Artemisiae Argyi 2～3%.