CN103385243B - A kind of bactericidal composition containing tiadinil and antibiotics - Google Patents
A kind of bactericidal composition containing tiadinil and antibiotics Download PDFInfo
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- CN103385243B CN103385243B CN201210142414.9A CN201210142414A CN103385243B CN 103385243 B CN103385243 B CN 103385243B CN 201210142414 A CN201210142414 A CN 201210142414A CN 103385243 B CN103385243 B CN 103385243B
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- VJQYLJSMBWXGDV-UHFFFAOYSA-N tiadinil Chemical compound N1=NSC(C(=O)NC=2C=C(Cl)C(C)=CC=2)=C1C VJQYLJSMBWXGDV-UHFFFAOYSA-N 0.000 title claims abstract description 69
- 239000000203 mixture Substances 0.000 title claims abstract description 39
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 17
- 239000003242 anti bacterial agent Substances 0.000 title claims abstract description 9
- 229940088710 antibiotic agent Drugs 0.000 title claims abstract description 9
- 229930182764 Polyoxin Natural products 0.000 claims abstract description 29
- YEBIHIICWDDQOL-YBHNRIQQSA-N polyoxin Polymers O[C@@H]1[C@H](O)[C@@H](C(C=O)N)O[C@H]1N1C(=O)NC(=O)C(C(O)=O)=C1 YEBIHIICWDDQOL-YBHNRIQQSA-N 0.000 claims abstract description 29
- 201000010099 disease Diseases 0.000 claims abstract description 20
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 20
- 239000000375 suspending agent Substances 0.000 claims description 29
- 235000007164 Oryza sativa Nutrition 0.000 claims description 18
- 235000009566 rice Nutrition 0.000 claims description 18
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 claims description 16
- 239000003094 microcapsule Substances 0.000 claims description 16
- 239000000839 emulsion Substances 0.000 claims description 14
- 241000233679 Peronosporaceae Species 0.000 claims description 13
- 230000035613 defoliation Effects 0.000 claims description 10
- 239000004563 wettable powder Substances 0.000 claims description 9
- 241000221785 Erysiphales Species 0.000 claims description 8
- 206010039509 Scab Diseases 0.000 claims description 8
- 230000001580 bacterial effect Effects 0.000 claims description 8
- 241000918585 Pythium aphanidermatum Species 0.000 claims description 7
- 239000000725 suspension Substances 0.000 claims description 7
- 239000004562 water dispersible granule Substances 0.000 claims description 7
- 241001530056 Athelia rolfsii Species 0.000 claims description 6
- 206010027146 Melanoderma Diseases 0.000 claims description 6
- 239000004530 micro-emulsion Substances 0.000 claims description 5
- 240000007594 Oryza sativa Species 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 15
- 230000002265 prevention Effects 0.000 abstract description 7
- 238000005406 washing Methods 0.000 abstract description 2
- 230000000855 fungicidal effect Effects 0.000 abstract 1
- 238000001228 spectrum Methods 0.000 abstract 1
- 239000003814 drug Substances 0.000 description 37
- 238000012360 testing method Methods 0.000 description 29
- 239000002131 composite material Substances 0.000 description 20
- 241000209094 Oryza Species 0.000 description 17
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 15
- 239000013530 defoamer Substances 0.000 description 13
- 239000002270 dispersing agent Substances 0.000 description 13
- 230000003449 preventive effect Effects 0.000 description 11
- 230000002195 synergetic effect Effects 0.000 description 11
- 239000000575 pesticide Substances 0.000 description 10
- 239000000470 constituent Substances 0.000 description 9
- 239000008367 deionised water Substances 0.000 description 9
- 229910021641 deionized water Inorganic materials 0.000 description 9
- 239000003995 emulsifying agent Substances 0.000 description 9
- 239000002904 solvent Substances 0.000 description 9
- 239000000080 wetting agent Substances 0.000 description 9
- 240000008067 Cucumis sativus Species 0.000 description 7
- 235000010799 Cucumis sativus var sativus Nutrition 0.000 description 7
- 230000002528 anti-freeze Effects 0.000 description 7
- 231100000419 toxicity Toxicity 0.000 description 7
- 230000001988 toxicity Effects 0.000 description 7
- 229940079593 drug Drugs 0.000 description 6
- 238000011835 investigation Methods 0.000 description 6
- 239000000463 material Substances 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- 239000002562 thickening agent Substances 0.000 description 6
- 231100000820 toxicity test Toxicity 0.000 description 6
- 206010011732 Cyst Diseases 0.000 description 5
- 206010067482 No adverse event Diseases 0.000 description 5
- 241000209140 Triticum Species 0.000 description 5
- 235000021307 Triticum Nutrition 0.000 description 5
- 239000004480 active ingredient Substances 0.000 description 5
- 230000010165 autogamy Effects 0.000 description 5
- 208000031513 cyst Diseases 0.000 description 5
- 230000005764 inhibitory process Effects 0.000 description 5
- 229920002521 macromolecule Polymers 0.000 description 5
- 239000012071 phase Substances 0.000 description 5
- 239000003381 stabilizer Substances 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 239000004094 surface-active agent Substances 0.000 description 5
- 244000141359 Malus pumila Species 0.000 description 4
- 235000011430 Malus pumila Nutrition 0.000 description 4
- 235000015103 Malus silvestris Nutrition 0.000 description 4
- 241000220317 Rosa Species 0.000 description 4
- 239000011230 binding agent Substances 0.000 description 4
- 239000000945 filler Substances 0.000 description 4
- 238000009472 formulation Methods 0.000 description 4
- -1 micro emulsionAgent Substances 0.000 description 4
- 239000003002 pH adjusting agent Substances 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Divinylene sulfide Natural products C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 3
- 239000008346 aqueous phase Substances 0.000 description 3
- 238000000498 ball milling Methods 0.000 description 3
- 239000007884 disintegrant Substances 0.000 description 3
- 238000013401 experimental design Methods 0.000 description 3
- 230000001965 increasing effect Effects 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 241000196324 Embryophyta Species 0.000 description 2
- 241000607479 Yersinia pestis Species 0.000 description 2
- 239000011149 active material Substances 0.000 description 2
- 239000003905 agrochemical Substances 0.000 description 2
- 230000008485 antagonism Effects 0.000 description 2
- 230000003115 biocidal effect Effects 0.000 description 2
- 235000013339 cereals Nutrition 0.000 description 2
- 235000013399 edible fruits Nutrition 0.000 description 2
- 230000009036 growth inhibition Effects 0.000 description 2
- 230000002045 lasting effect Effects 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 238000010008 shearing Methods 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 229930192474 thiophene Natural products 0.000 description 2
- 235000013311 vegetables Nutrition 0.000 description 2
- FRXSZNDVFUDTIR-UHFFFAOYSA-N 6-methoxy-1,2,3,4-tetrahydroquinoline Chemical compound N1CCCC2=CC(OC)=CC=C21 FRXSZNDVFUDTIR-UHFFFAOYSA-N 0.000 description 1
- 229930182536 Antimycin Natural products 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 108090000371 Esterases Proteins 0.000 description 1
- 240000003978 Ipomoea coccinea Species 0.000 description 1
- 241000813090 Rhizoctonia solani Species 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- CQIUKKVOEOPUDV-IYSWYEEDSA-N antimycin Chemical compound OC1=C(C(O)=O)C(=O)C(C)=C2[C@H](C)[C@@H](C)OC=C21 CQIUKKVOEOPUDV-IYSWYEEDSA-N 0.000 description 1
- 239000012752 auxiliary agent Substances 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 210000002421 cell wall Anatomy 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 238000004945 emulsification Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 230000004907 flux Effects 0.000 description 1
- UFHLMYOGRXOCSL-UHFFFAOYSA-N isoprothiolane Chemical compound CC(C)OC(=O)C(C(=O)OC(C)C)=C1SCCS1 UFHLMYOGRXOCSL-UHFFFAOYSA-N 0.000 description 1
- PVTHJAPFENJVNC-MHRBZPPQSA-N kasugamycin Chemical compound N[C@H]1C[C@H](NC(=N)C(O)=O)[C@@H](C)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)[C@@H]1O PVTHJAPFENJVNC-MHRBZPPQSA-N 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 244000144977 poultry Species 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 239000002718 pyrimidine nucleoside Substances 0.000 description 1
- 210000001082 somatic cell Anatomy 0.000 description 1
- 230000004763 spore germination Effects 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000001018 virulence Effects 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
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- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a kind of bactericidal composition containing tiadinil and antibiotics, the bactericidal composition that contains active components A and active component B, active components A is selected from tiadinil, active component B is selected from following any one composition: polyoxin, jinggangmeisu, kasugarnycin, and the weight ratio of active components A and active component B is 1 ︰ 60 ~ 80 ︰ 1. The multiple diseases that the present composition can be used for preventing and treating in multiple kinds of crops all has good prevention effect; Have that fungicidal spectrum is wide, dosage is little, resistance of rainwater washing against, the obvious feature of synergy.<!--1-->
Description
Technical field
The invention belongs to technical field of pesticide, relate to a kind of sterilization group containing tiadinil and antibioticsThe application of compound in crop pest.
Technical background
Tiadinil (Tiadinil) molecular formula: C11H10ClN3OS, chemical name: 3'-is chloro-4,4'-dimethyl-1,2,3-thiadiazoles-5-formailide, this medicament has well interior absorption, Ke YitongCross root absorption, and be transmitted to rapidly other positions, be suitable for the water surface and use, the lasting period is long, rightLeaf blast disease and fringe rice blast have good prevention effect.
Polyoxin (polyoxin) chemical name: peptide pyrimidine nucleoside, molecular formula: C17H25N5O14，Polyoxin belongs to broad-spectrum antibiotics class, has interior conduction, its effect machine inhaled preferablySystem is to disturb the chitinous biosynthesis of bacterial cell wall, after germ tube contacts medicament with mycelium, and officeCell inclusion is expanded, breaks, overflowed in portion, and can not normal development, causes death, also hasSuppress germ and produce spore and scab expansion effect, this medicine does not have toxicity to animal, and plant is not had to medicineEvil.
Jinggangmeisu (jingangmycin) chemical name: N-[(1S)-(Isosorbide-5-Nitrae, 6/5)-3-methylol-4,5,6-trihydroxy-2-cyclohexenyl group] [O-β-D-glucopyranosyl-(1 → 3)]-1S-(1,2,4,3,5)-2,3,4-trihydroxy-5-methylol-cyclo-hexylamine, molecular formula: C20H35O13N, wellRidge mycin is the agricultural antibiotic that systemic action is very strong, when the mycelia of Rhizoctonia solani Kuhn touchesAfter jinggangmeisu, can be absorbed by somatic cells very soon and conduct in thalline, disturb and inhibition bacteriumBody cell normal growth is grown, thereby plays therapeutic action. Well ridge is mouldElement also can be used for preventing and treating wheat sharp eyespot, false smut etc.
Kasugarnycin (kasugamycin) chemical name: [5-amino-2-methyl-6-(2,3,4,5,6-carbonyl cyclohexyl oxo) pyrans-3-base amino-a-IMDA], molecular formula: C14H25N3O9，Kasugarnycin is agricultural antibiotic, has stronger interior absorption, and this medicine mainly disturbs amino acid whoseMetabolism esterase system, thus the synthetic of protein affected, suppress mycelia elongation and cause cellGranulation, but on spore germination without impact.
Summary of the invention
Tiadinil, polyoxin, jinggangmeisu, the long-term use of kasugarnycin single dose may bring anti-Property occur, degradation problem under drug effect, the bactericidal composition that the present invention proposes contain active components A withActive component B, and appropriate surfactant and carrier.
A kind of bactericidal composition, contains active components A and active component B, it is characterized in that: active one-tenthDividing A and active component B weight ratio is 1 ︰ 60 ~ 80 ︰ 1, and described active components A is selected from thiophene acyl bacteriumAmine, active component B is selected from the one in polyoxin, jinggangmeisu, kasugarnycin, Isoprothiolane, active components A and the preferred weight ratio of active component B are 1 ︰ 40 ~ 60 ︰ 1; More preferably thiophene acylThe weight ratio of bacterium amine and polyoxin is 1 ︰ 20 ~ 20 ︰ 1, the weight of tiadinil and jinggangmeisuThan being 1 ︰ 20 ~ 20 ︰ 1, tiadinil and kasugarnycin weight ratio are 1 ︰ 10 ~ 20 ︰ 1.
Described bactericidal composition is used for preventing and treating on cereal crop, fruit tree, vegetables, ornamental plant sickThe purposes of evil.
Described disease comprises: powdery mildew, downy mildew, early blight, scab, banded sclerotial blight, grey moldDisease, rust, epidemic disease, rust, spot defoliation, leaf mold, droop, soft rot,Bacterial angular leaf spot, rice blast, false smut, damping-off, leaf blight, black spot, charcoalSubcutaneous ulcer disease, brown spot, late blight.
The weight ratio of active components A and active component B is 1 ︰ 60 ~ 80 ︰ 1. Conventionally in composition active groupPoint weight percentage be gross weight 0.5%～90%, be preferably 5%～80%. According to notSame preparation type, active component content scope is different. Conventionally, liquid preparation contain byThe active material of weighing scale 0.5%～70% is preferably 5%～50%; Solid pharmaceutical preparation contains by heavyThe active material of amount meter 5%～80% is preferably 10%～80%.
In bactericidal composition of the present invention, at least contain a kind of surfactant, activity while being beneficial to useThe dispersion of component in water. Surface-active contents is 5%～30% of total formulation weight amount, and surplus isSolid or liquid diluent.
The selected surfactant of bactericidal composition of the present invention is known in those skilled in the art: can be selected from one or more in dispersant, wetting agent, binding agent or defoamer. According toDifferent dosage form, can also contain disintegrant known in those skilled in the art, freeze proof in preparationAgent etc.
Bactericidal composition of the present invention can be by user before use through dilution or directly use. It is joinedSystem can be prepared by common processing method known in those skilled in the art, by active materialAfter mixing with liquid flux or solid carrier, then add surfactant as dispersant, stabilizing agent, one or more in wetting agent, binding agent, defoamer etc.
Bactericidal composition of the present invention, can be processed into acceptable formulation on any agricultural chemicals on demand,Wherein more excellent formulation is: wettable powder, water dispersible granules, suspending agent, aqueous emulsion, micro emulsionAgent, microcapsule suspending agent, microcapsules suspension-suspending agent, suspension emulsion.
When making wettable powder, composition comprises following constituent content: active components A1% ~ 80%, active component B1% ~ 60%, dispersant 2% ~ 10%, wetting agent 2% ~ 10%, filler surplus。
When making water dispersible granules, composition comprises following constituent content: active components A 1% ~ 80%,Active component B1% ~ 60%, dispersant 3% ~ 12%, wetting agent 1% ~ 8%, disintegrant 1% ~ 10%,Binding agent 0 ~ 4%, filler surplus.
When making suspending agent, composition comprises following constituent content: active components A 0.1% ~ 50%, activityComposition B0.1% ~ 50%, dispersant 2% ~ 10%, wetting agent 2% ~ 10%, defoamer 0.01% ~ 2%,Thickener 0.05% ~ 2%, antifreeze 0 ~ 8%, deionized water add to 100%.
When making aqueous emulsion, composition comprises following constituent content: active components A 0.1% ~ 50%, activityComposition B0.1% ~ 50%, solvent 0 ~ 30%, emulsifying agent 1% ~ 15%, antifreeze 0 ~ 8%, thickener0.05% ~ 2%, defoamer 0.01% ~ 2%, deionized water are supplied surplus.
When making microemulsion, composition comprises following constituent content: active components A 0.1% ~ 50%, activityComposition B0.1% ~ 50%, solvent 0 ~ 30%, emulsifying agent 3% ~ 20%, antifreeze 0 ~ 8%, thickener0.05% ~ 2%, defoamer 0.01% ~ 2%, stabilizing agent 0 ~ 4%, deionized water is supplied surplus.
When making microcapsule suspending agent, composition comprises following constituent content: active components A 0.1% ~ 50%,Active component B0.1% ~ 50%, macromolecule cyst material 2% ~ 10%, dispersant 1% ~ 10%, solvent0 ~ 10%, emulsifying agent 1% ~ 7%, pH adjusting agent 0.01% ~ 5%, deionized water add to 100%.
When making microcapsule suspension-suspending agent, composition comprises following constituent content: active components A 0.1%~ 50%, active component B0.1% ~ 50%, macromolecule cyst material 2% ~ 12%, surfactant 3% ~ 15%, solvent 1% ~ 15%, emulsifying agent 1% ~ 6%, defoamer 0.01% ~ 2%,Thickener 0.05% ~ 2%, pH adjusting agent 0.01% ~ 5%, deionized water add to 100%.
When making suspension emulsion, composition comprises following constituent content: active components A 0.1% ~ 50%, activityComposition B0.1% ~ 50%, dispersant 2% ~ 10%, defoamer 0.01% ~ 2%, solvent 0 ~ 15%, increasingThick dose 0.05% ~ 2%, emulsifying agent 2% ~ 12%, antifreeze 0 ~ 8%, stabilizing agent 0 ~ 3%, deionized waterAdd to 100%.
Wettable powder the key technical indexes of the present invention:
Water dispersible granules the key technical indexes of the present invention:
Suspending agent the key technical indexes of the present invention:
Aqueous emulsion the key technical indexes of the present invention:
Microemulsion the key technical indexes of the present invention:
Microcapsule suspending agent the key technical indexes of the present invention:
Microcapsule suspension-suspending agent the key technical indexes of the present invention:
Suspension emulsion the key technical indexes of the present invention:
The invention has the advantages that:
(1) tiadinil, polyoxin, jinggangmeisu, kasugarnycin composite after, have brightAobvious synergy and lasting effect; (2) on cereal crop, fruit tree, vegetables, ornamental plantPowdery mildew, downy mildew, early blight, scab, banded sclerotial blight, gray mold, rust, epidemic disease, rust, spot defoliation, leaf mold, droop, soft rot, bacterial angular leaf spot,Rice blast, false smut, damping-off, leaf blight, black spot, anthracnose, brown spot, late blightDisease etc. all has special efficacy; (3) reduce agricultural chemicals dosage, reduced residual on crop of agricultural chemicalsAmount, has alleviated environmental pollution; (4), to person poultry safety, Environmental compatibility is good; And preparation adhesionPower strengthens, resistance of rainwater washing against.
Detailed description of the invention
Below in conjunction with embodiment, to further instruction of the present invention, the percentage in embodiment is weightPercentage, but the present invention is not limited thereto.
Application Example one
Example 1 ~ 15 wettable powder
Tiadinil, active ingredient B, dispersant, wetting agent, filler are mixed, mixed in mixed cylinderClose evenly, after airslide disintegrating mill is pulverized, mix again, can be made into of the present invention canWP product. Specifically in table 1.
The each component of table 1 example 1 ~ 15 and content
Example 16 ~ 21 water dispersible granules
By tiadinil, active ingredient B, dispersant, wetting agent, binding agent, disintegrant, filler oneRise through air-flow crushing and obtain the particle diameter needing, obtain the materials of granulating. Quantitatively send item to fluidisationIn bed granulating drier, after granulating and being dried, make water dispersible granules of the present invention and produceProduct. Specifically in table 2.
The each component of table 2 example 16 ~ 21 and content
Example 22 ~ 27 suspending agents
Dispersant, wetting agent, defoamer, thickener, antifreeze are mixed through high speed shear, adding tiadinil, active ingredient B, surplus is supplied by deionized water, ball milling in ball mill2 ~ 3 hours, make diameter of particle all below 5 μ m, make oil-suspending agent of the present invention and produceProduct. Specifically in table 3.
The each component of table 3 example 22 ~ 27 and content
Example 28 ~ 30 suspension emulsions
By dispersant, defoamer, thickener, antifreeze, stabilizing agent, solvent warp in above-mentioned formulation materialCross high speed shear-mixed even, add tiadinil, in ball mill, ball milling 2 ~ 3 hours, makes micro-Grain particle diameter all, below 5 μ m, makes tiadinil suspending agent, then by active component B, breastAgent and various auxiliary agent in suspending agent, make of the present invention with the direct emulsification of high speed agitatorSuspension emulsion product. Specifically in table 4.
The each component of table 4 example 39 ~ 44 and content
Example 31 ~ 33 microemulsions
Tiadinil, active ingredient B are dissolved in the homogenizer that solvent is housed, by emulsifying agent, freeze proofAgent, defoamer, stabilizing agent join in the homogenizer that above-mentioned solution is housed, surplus deionizationWater gives strong mixing and homogenize after supplying, finally obtain as clear as crystal of the present invention of outward appearanceMicroemulsion product. Specifically in table 5.
The each component of table 5 example 31 ~ 33 and content
Example 34 ~ 45 aqueous emulsions
Tiadinil, active ingredient B, solvent, emulsifying agent are added together, make to be dissolved into even oil phase; Deionized water, antifreeze, thickener, defoamer are mixed, become homogeneous water.Under high-speed stirred, water is added to oil phase, make aqueous emulsion product of the present invention. ToolBody is in table 6.
The each component of table 6 example 34 ~ 45 and content
Example 46 ~ 48 microcapsule suspending agents
By tiadinil, active component B, macromolecule cyst material, solvent, make to be dissolved into evenlyOil phase, under shearing condition, joins oil phase to contain emulsifying agent, pH adjusting agent, dispersant, defoamer aqueous phase solution in, surplus is supplied by deionized water, bi-material is at oil-water interfacesReact, form macromolecule cyst wall, make the finely disseminated microcapsule suspension of the present compositionAgent product. Specifically in table 7.
The each component of table 7 example 46 ~ 48 and content
Example 49,50 microcapsule suspensions-suspending agent
By active component B, macromolecule cyst material, solvent, make to be dissolved into even oil phase, by oilUnder shearing condition, join in the aqueous phase solution that contains emulsifying agent, pH adjusting agent, make pointLoose good microcapsule suspending agent. By dispersant, wetting agent, defoamer, thickener process at a high speedShear-mixed is even, adds tiadinil, and in ball mill, ball milling 2 ~ 3 hours, makes diameter of particleAll, below 5 μ m, make suspending agent, then suspending agent is joined to micro-capsule suspensionIn aqueous phase solution, deionized water is supplied surplus, makes the finely disseminated micro-capsule of the present compositionSuspension-suspending agent product. Specifically in table 8.
Table 8 example 49,50 each component and content
Active component B polyoxin, jinggangmeisu, kasugarnycin in table 1 ~ 8 are exchanged, can make newPreparation.
The embodiment of the present invention is the method that adopts Toxicity Determination and field test to combine. The present inventionEmbodiment is the method that adopts Toxicity Determination and field test to combine. First by indoor poisonPower is measured, the synergy ratio (SR) after clear and definite two kinds of medicaments are composite by a certain percentage, SR < 0.5 is antagonism, and 0.5≤SR≤1.5 are summation action, and SR > 1.5 is synergistic effect, at thisOn basis, then carry out field test.
Tiadinil and active component B are composite to crop pest Toxicity Determination. Determine each medicine through prerunAfter the effective inhibition concentration scope of agent, each medicament is established respectively 5 dosage processing by active constituent content, establish clear water contrast. Carry out with reference to " farm-chemical indoor determination test rule bactericide ", adoptVirulence with mycelial growth rate method mensuration medicament to crop germ. After 72h, survey by right-angled intersection methodAmount colony diameter, calculates each processing net growth, mycelial growth inhibition rate.
Net growth (mm)=measurement colony diameter-5
Mycelial growth inhibition rate is converted into probit value (y), and it is right that liquor strength (μ g/mL) converts toNumerical value (x), is tried to achieve virulence regression equation (y=a+bx) with least square method, and calculates thusGo out the EC of every kind of medicament50Value. Calculate the different proportioning synergies of two medicaments according to Wadley method simultaneouslyRatio (SR), SR < 0.5 is antagonism, 0.5≤SR≤1.5 are summation action, SR > 1.5 be synergistic effect. Computing formula is as follows:
Wherein: a, b are respectively active component tiadinil and active component B shared ratio in combination；
A is tiadinil;
B is the one in polyoxin, kasugarnycin, jinggangmeisu.
Implementation of an application example two: tiadinil and polyoxin are composite to cucumber downy mildew Toxicity Determination。
Test medicine provides by Shaanxi Welch Crop Protection Co., Ltd..
Experimental design: determine that through pilot study tiadinil, the former medicine of polyoxin and the two difference joinThan effective inhibition concentration scope of mixture.
Toxicity test result
Table 9 tiadinil, polyoxin and the composite toxicity test analysis of results table to cucumber downy mildew thereof
As shown in Table 9, tiadinil, the EC of polyoxin to cucumber downy mildew50Be respectively 3.01mg/ L and 2.54mg/L, and proportioning is in the time of 80:1 to 1:60, and synergy ratio SR is all greater than 1.5,Illustrate that tiadinil and polyoxin mixture in 80 ︰ 1 to 1 ︰ 60 scopes all shows increasingEffect effect, especially, when the two proportioning is during at 1:20 to 20:1, synergistic effect is more obviousOutstanding, synergy ratio is all greater than 2.0, and wherein working as tiadinil and polyoxin weight ratio is 1 ︰1 o'clock synergy ratio SR maximum, synergistic effect is the most obvious, and test is found, when tiadinil is with manyThe proportioning of antimycin is at 20:1,15:1,10:1,9:1,8:1,7:1,6:1,5:1、4：1、3：1、2：1、1：1、1：2、1：3、1：4、1：5、1：6、1：7, when 1:8,1:9,1:10,1:15,1:20 to powdery mildew, downy mildew, early blight,Scab, banded sclerotial blight, gray mold, rust, epidemic disease, rust, spot defoliation, leaf moldDisease, droop, soft rot, bacterial angular leaf spot, rice blast, false smut, damping-off, leafRot, black spot, anthracnose, brown spot, late blight synergistic effect are obvious, and synergy ratio is equalBe greater than 1.5.
Implementation of an application example three: tiadinil and composite jinggangmycin are to rice sheath blight disease Toxicity Determination。
Test medicine provides by Shaanxi Welch Crop Protection Co., Ltd..
Experimental design: determine that through pilot study tiadinil, the former medicine of jinggangmeisu and the two difference joinThan effective inhibition concentration scope of mixture.
Toxicity test result
Table 10 tiadinil, jinggangmeisu and the composite toxicity test interpretation of result to rice sheath blight disease thereofTable
As shown in Table 10, tiadinil, the EC of jinggangmeisu to rice sheath blight disease50Be respectively 2.93mg/L and 2.42mg/L, and proportioning is in the time of 80:1 to 1:60, and synergy ratio SR is all greater than 1.5,Illustrate that tiadinil and jinggangmeisu mixture in 80 ︰ 1 to 1 ︰ 60 scopes all shows increasingEffect effect, especially, when the two proportioning is during at 1:20 to 20:1, synergistic effect is more obviousOutstanding, synergy ratio is all greater than 2.00, and wherein working as tiadinil and jinggangmeisu weight ratio is 1 ︰5 o'clock synergy ratio SR maximums, synergistic effect is the most obvious, examinationIssue after examination and approval existing, when the proportioning of tiadinil and jinggangmeisu 20:1,15:1,10:1,9:1,8：1、7：1、6：1、5：1、4：1、3：1、2：1、1：1、1：2、1：3、When 1:4,1:5,1:6,1:7,1:8,1:9,1:10,1:15,1:20 to white powderDisease, downy mildew, early blight, scab, banded sclerotial blight, gray mold, rust, epidemic disease, red starDisease, spot defoliation, leaf mold, droop, soft rot, bacterial angular leaf spot, rice blast, false smut, damping-off, leaf blight, black spot, anthracnose, brown spot, late blight synergyObviously, synergy ratio is all greater than 1.5 in effect.
Implementation of an application example four: tiadinil and kasugarnycin are composite to rice blast Toxicity Determination。
Test medicine provides by Shaanxi Welch Crop Protection Co., Ltd..
Experimental design: determine that through pilot study tiadinil, the former medicine of kasugarnycin and the two difference joinThan effective inhibition concentration scope of mixture.
Toxicity test result
Table 11 tiadinil, kasugarnycin and the composite toxicity test interpretation of result to rice blast thereofTable
As shown in Table 11, tiadinil, the EC of kasugarnycin to rice blast50Be respectively 2.98mg/L and 1.04mg/L, and proportioning is in the time of 80:1 to 1:60, and synergy ratio SR is all greater than 1.5,Illustrate that tiadinil and kasugarnycin mixture in 80 ︰ 1 to 1 ︰ 60 scopes all shows increasingEffect effect, especially, when the two proportioning is during at 1:10 to 20:1, synergistic effect is more obviousOutstanding, synergy ratio is all greater than 2.00, and wherein working as tiadinil and kasugarnycin weight ratio is 5 ︰1 o'clock synergy ratio SR maximum, synergistic effect is the most obvious, and test is found, when tiadinil and springThe proportioning of thunder mycin is at 20:1,15:1,10:1,9:1,8:1,7:1,6:1,5：1、4：1、3：1、2：1、1：1、1：2、1：3、1：4、1：5、1：6、1: 7, when 1:8,1:9,1:10 to powdery mildew, downy mildew, early blight, scab, lineRot, gray mold, rust, epidemic disease, rust, spot defoliation, leaf mold, droop, soft rot, bacterial angular leaf spot, rice blast, false smut, damping-off, leaf blight, blackspotDisease, anthracnose, brown spot, late blight synergistic effect are obvious, and synergy ratio is all greater than 1.5.
Application Example five tiadinils and the examination of the composite control rice blast of active component B drug effectTest
This EE is in Hanzhong City suburb, Shaanxi Province, and test medicine is had by Shaanxi Wei Erqi crop protectionLimit company provides, and contrast medicament 24% tiadinil suspending agent (autogamy), 3% polyoxin are wettableProperty pulvis (commercial), 5% jinggangmeisu aqua (commercial), 2% kasugarnycin wettable powder(commercial).
The investigation rice blast state of an illness before medicine, in the dispenser for the first time of state of an illness initial stage, dispenser in every 10 days once, dispenser 2 times altogether. Within after dispenser 7 days, 14 days, 30 days for the second time, investigation is sick respectivelyFeelings index also calculates preventive effect. Experimental result is as follows:
Table 12 tiadinil and the active component B control rice blast test of pesticide effectiveness
As can be seen from Table 12, tiadinil and polyoxin, jinggangmeisu, kasugarnycin composite afterCan effectively prevent and treat rice blast, prevention effect is all better than the preventive effect of single dose, and efficiency time is long; In test scope of medication, target crop is had no adverse effects.
Application Example six tiadinils and the composite control of active component B apple tree spot defoliationThe test of pesticide effectiveness
This EE is at Shaanxi Province's Weinan City Baishui County, and test medicine is by Shaanxi Wei Erqi crop protectionCo., Ltd provides, and contrast medicament 24% tiadinil suspending agent (autogamy), 3% polyoxin canWP (commercial), 5% jinggangmeisu aqua (commercial), 2% kasugarnycin wettable powderAgent (commercial).
Before medicine, the investigation apple tree spot defoliation state of an illness, in the dispenser for the first time of state of an illness initial stage, executes for every 10 daysMedicine once, is total to dispenser 2 times. Within after dispenser 7 days, 14 days, 30 days for the second time, investigate respectively the state of an illness and refer toCount and calculate preventive effect. Experimental result is as follows:
Table 13 tiadinil and the active component B control apple tree spot defoliation test of pesticide effectiveness
As can be seen from Table 13, tiadinil and polyoxin, jinggangmeisu, kasugarnycin composite afterEnergy effectively preventing and treating apple-tree spot defoliation, prevention effect is all better than the preventive effect of single dose, and holding effectTime is long; In test scope of medication, target crop is had no adverse effects.
Application Example seven tiadinils and the composite control cucumber downy mildew of the active component B test of pesticide effectiveness
This EE is at Xian District, Shanxi Province suburban area, and test medicine is had by Shaanxi Wei Erqi crop protectionLimit company provides, and contrast medicament 24% tiadinil suspending agent (autogamy), 3% polyoxin are wettableProperty pulvis (commercial), 5% jinggangmeisu aqua (commercial), 2% kasugarnycin wettable powder(commercial).
The investigation cucumber downy mildew state of an illness before medicine, in the dispenser for the first time of state of an illness initial stage, dispenser in every 10 days once, dispenser 2 times altogether. Within after dispenser 7 days, 14 days, 30 days for the second time, investigate respectively disease index meterCalculate preventive effect. Experimental result is as follows:
Table 14 tiadinil and the active component B control cucumber downy mildew test of pesticide effectiveness
As can be seen from Table 14, tiadinil and polyoxin, jinggangmeisu, kasugarnycin composite afterCan effectively prevent and treat cucumber downy mildew, prevention effect is all better than the preventive effect of single dose, and efficiency time is long; In test scope of medication, target crop is had no adverse effects.
Application Example eight tiadinils and the composite control of the active component B rose powdery mildew test of pesticide effectiveness
This EE is in suburb, Kunming, Yunnan Province, and test medicine is had by Shaanxi Wei Erqi crop protectionLimit company provides, and contrast medicament 24% tiadinil suspending agent (autogamy), 3% polyoxin are wettableProperty pulvis (commercial), 5% jinggangmeisu aqua (commercial), 2% kasugarnycin wettable powder(commercial).
The investigation rose powdery mildew state of an illness before medicine, in the dispenser for the first time of state of an illness initial stage, dispenser in every 10 days once, dispenser 2 times altogether. Within after dispenser 7 days, 14 days, 30 days for the second time, investigate respectively disease index meterCalculate preventive effect. Experimental result is as follows:
Table 15 tiadinil and the active component B control rose powdery mildew test of pesticide effectiveness
As can be seen from Table 15, tiadinil and polyoxin, jinggangmeisu, kasugarnycin composite afterCan effectively prevent and treat rose powdery mildew, prevention effect is all better than the preventive effect of single dose, and efficiency time is long; In test scope of medication, target crop is had no adverse effects.
The composite wheat rust test of pesticide effectiveness of preventing and treating of Application Example nine tiadinils and active component B
This EE is in Baqiao District, Xi'an City, Shanxi Province, and test medicine is by Shaanxi Wei Erqi crop protectionCo., Ltd provides, and contrast medicament 24% tiadinil suspending agent (autogamy), 3% polyoxin canWP (commercial), 5% jinggangmeisu aqua (commercial), 2% kasugarnycin wettable powderAgent (commercial).
The investigation wheat rust state of an illness before medicine, in the dispenser for the first time of state of an illness initial stage, dispenser in every 10 days once,Dispenser 2 times altogether. Within after dispenser 7 days, 14 days, 30 days for the second time, investigate respectively disease index and calculatePreventive effect. Experimental result is as follows:
Table 16 tiadinil and active component B prevent and treat the wheat rust test of pesticide effectiveness
As can be seen from Table 16, tiadinil and polyoxin, jinggangmeisu, kasugarnycin composite afterCan effectively prevent and treat wheat rust, prevention effect is all better than the preventive effect of single dose, and efficiency time is long;In test scope of medication, target crop is had no adverse effects.
After draw through different local throughout the country tests, tiadinil and polyoxin, Jing GangMycin, composite wettable powder, water dispersible granules, suspending agent, the suspension emulsion made of kasugarnycin, white to all kinds of crops after aqueous emulsion, microemulsion, microcapsule suspending agent, microcapsule suspension-suspending agentPowder disease, downy mildew, early blight, scab, banded sclerotial blight, gray mold, rust, epidemic disease, redStar disease, spot defoliation, leaf mold, droop, soft rot, bacterial angular leaf spot, rice blastDisease, false smut, damping-off, leaf blight, black spot, anthracnose, brown spot, late blight etc.The preventive effect of Common Diseases all, more than 95%, is better than single dose preventive effect, and synergistic effect is obvious.
Claims (6)
1. the bactericidal composition containing tiadinil and antibiotics, contain active components A and active component B, it is characterized in that: active components A and active component B weight ratio are 1 ︰ 60 ~ 80 ︰ 1, described active components A is selected from tiadinil, and active component B is selected from the one in polyoxin, jinggangmeisu, kasugarnycin.
2. the bactericidal composition containing tiadinil and antibiotics according to claim 1, is characterized in that: the weight ratio of active components A and active component B is 1 ︰ 40 ~ 60 ︰ 1.
3. the bactericidal composition containing tiadinil and antibiotics according to claim 2, is characterized in that:
The weight ratio of tiadinil and polyoxin is 1 ︰ 20 ~ 20 ︰ 1;
The weight ratio of tiadinil and jinggangmeisu is 1 ︰ 20 ~ 20 ︰ 1;
The weight ratio of tiadinil and kasugarnycin is 1 ︰ 10 ~ 20 ︰ 1.
4. according to the bactericidal composition containing tiadinil and antibiotics described in any one in claims 1 to 3, it is characterized in that: composition is made wettable powder, water dispersible granules, suspending agent, suspension emulsion, aqueous emulsion, microemulsion, microcapsule suspending agent, microcapsule suspension-suspending agent.
5. the bactericidal composition containing tiadinil and antibiotics according to claim 4 is for preventing and treating the purposes of disease on crops.
6. purposes according to claim 5, it is characterized in that, described disease comprises: powdery mildew, downy mildew, scab, banded sclerotial blight, gray mold, rust, epidemic disease, rust, spot defoliation, leaf mold, droop, soft rot, bacterial angular leaf spot, rice blast, false smut, damping-off, leaf blight, black spot, anthracnose, brown spot.
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| CN101473829A (en) * | 2008-12-18 | 2009-07-08 | 孙家隆 | Bactericide agent composition containing tiadinil and flutolanil |
| CN102007934A (en) * | 2010-12-20 | 2011-04-13 | 陕西韦尔奇作物保护有限公司 | Bactericidal composition containing phosethyl-Al and antibiotic compound |
| CN102057914A (en) * | 2010-12-27 | 2011-05-18 | 陕西美邦农药有限公司 | Bactericidal composition containing metconazole and antibiotic compound |
| CN102057909A (en) * | 2010-12-23 | 2011-05-18 | 陕西韦尔奇作物保护有限公司 | Bactericidal composition containing triflumizole and antibiotic compounds |
| CN102308801A (en) * | 2011-04-28 | 2012-01-11 | 陕西韦尔奇作物保护有限公司 | Germicide composition containing spiroxamine and antibiotics compound |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101473829A (en) * | 2008-12-18 | 2009-07-08 | 孙家隆 | Bactericide agent composition containing tiadinil and flutolanil |
| CN102007934A (en) * | 2010-12-20 | 2011-04-13 | 陕西韦尔奇作物保护有限公司 | Bactericidal composition containing phosethyl-Al and antibiotic compound |
| CN102057909A (en) * | 2010-12-23 | 2011-05-18 | 陕西韦尔奇作物保护有限公司 | Bactericidal composition containing triflumizole and antibiotic compounds |
| CN102057914A (en) * | 2010-12-27 | 2011-05-18 | 陕西美邦农药有限公司 | Bactericidal composition containing metconazole and antibiotic compound |
| CN102308801A (en) * | 2011-04-28 | 2012-01-11 | 陕西韦尔奇作物保护有限公司 | Germicide composition containing spiroxamine and antibiotics compound |
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