CN103371366B - Product with effects of invigorating stomach and protecting liver - Google Patents

Abstract

The invention discloses a product with effects of invigorating stomach and protecting liver. The main components of the product comprise the following raw materials in parts by weight: hot water extracts of radix puerariae and hovenia dulcis thunb, and are characterized by also comprising hot water extracts of fructus amomi, Poria cocos, ginger and dried tangerine or orange peel. The production method comprises the following steps of: grinding raw materials, mixing, decocting, filtering, concentrating or drying, pelletizing and pressing. The product has the effects of protecting liver, invigorating stomach and tonifying spleen, can be chewed before, during and after drinking, has the functions of invigorating stomach and protecting liver, is fast in effect, high in efficiency and free form toxic or side effect and is suitable for excessive drinking people.

Description

A kind of product with promoting digestion and protecting liver function

Technical field:

The present invention relates to a kind of product and the preparation technology thereof with promoting digestion and protecting liver function.

Background technology:

Present promoting digestion and protecting liver class Orally taken product is more, and mouthfeel is poor generally, takes inconvenience.

Summary of the invention:

The object of the invention is to want to provide a kind of product with promoting digestion and protecting liver function newly, effect that this formula should have stomach invigorating, protect the liver, has good mouthfeel again, is easy to people and accepts, and safety, have no side effect.

For realizing above-mentioned purpose of the present invention, the technical scheme adopted is: according to listed as parts by weight, and this product is made up of the root of kudzu vine 50 ~ 100 parts, hoveniae semoveniae semen 50 ~ 100 parts, fructus amomi 10 ~ 50 parts, 5 ~ 20 parts, ginger, dried orange peel 10 ~ 50 parts, 50 ~ 100 parts, Poria cocos.

The preparation technology of product of the present invention is: get the root of kudzu vine, hoveniae semoveniae semen, fructus amomi, ginger, dried orange peel, Poria cocos, pulverizes, boiling twice, first time adds 8 ~ 15 times of water gagings, micro-decoction 1 ~ 2 hour of boiling by weight, and second time adds 6 ~ 10 times of water gagings by weight, micro-decoction 0.5 ~ 1 hour of boiling, collecting decoction, filters, concentrated, dry, add auxiliary material, through granulating, dry, whole grain, total mixed, compressing tablet, makes masticatory pattern oral formulations.

Compatibility reason of the present invention is:

The root of kudzu vine (Radix Puerariae) is the dry root of legume pueraria lobata Pueraria Iobata (Willd.) Ohwi.Begin to be loaded in Shennong's Herbal, record like this in Compendium of Material Medica: " Pueraria lobota, property is sweet, pungent, flat, nontoxic, cures mainly: quench one's thirst, high fever of the body, vomiting, all frauds, cloudy gas, separates all poison.”。Return spleen, stomach warp, have relieving muscles to expel heat, promote the production of body fluid, promoting eruption, rise the function of positive antidiarrheal.The function that the root of kudzu vine is used for relieving the effect of alcohol is mentioned with regard to there being a large amount of treatises in Ancient Times in China, and such as supplement to the Herbal is recorded: " (root of kudzu vine) survivor breaks blood, closes sore, induced abortion, relieving alcoholism, and body heat is red, and wine is yellow, hot urination." " property of medicine opinion " record: " and (root of kudzu vine) control sky capable on gas, vomit inverse, whetting the appetite, main relieving alcoholism, only polydipsia.Endure bits and control metal-inflicted wound, when controlling, disease is antipyretic." " prescriptions worth thousand gold " record: " a pipeful of two liters of kudzuvine root juice, drinks it, gets awake, only.”。Recent studies finds, Pueraria Flavonid is the principle active component of kudzu root extract, and Puerarin is that a kind of active monomer component in general flavone all has preventing drunkenness, controls the effects such as drunk and antagonism alcoholic liver injury.The discoveries such as Liu Yinong, no matter before wine after drinking, root of kudzu vine extract all has the effect of good sober up effect and protection liver, Stomach duodenum to mouse.The people such as Feng Qin confirm the root of kudzu vine Aqueous extracts gavage test of the rat of alcoholic liver injury: root of kudzu vine Aqueous extracts has the effect of significant anti-chronic alcohol liver injury.

Hoveniae semoveniae semen is the seed of Rhamnaceae Hovenia plant trifoliate orange root Hovenia acerba Lind1.L and northern trifoliate orange Dulcis Hovenia dulcis Thunb..Property is put down, and taste is sweet, enters stomach warp.Tool relieving alcoholism, relieving restlessness quench the thirst, preventing or arresting vomiting, profit two function just, are used for the treatment of the diseases such as drunk, polydipsia, vomiting, difficulty in urination and defecation.Modern pharmacological research shows: hoveniae semoveniae semen aqueous extract in advance gastric infusion can stop the mouse liver MDA caused by ethanol to raise and glutathione decline, and the cholesterol of energy caused by Anti-ethanol, olein increase; Raisin tree seed extract significantly can reduce Serum hyaluronic acid, I procollagen type, type III precollagen and Growth of Cells transforming factor β 1 content, alleviates Liver Collagen fibroplasia degree; Hoveniae semoveniae semen aqueous extract significantly can suppress the nitric oxide production release of Turnover of Mouse Peritoneal Macrophages, and this may be one of mechanism of its hepatoprotective effect; Hoveniae semoveniae semen aqueous extract can obviously shorten alcohol induced mouse sleep time, reduces the concentration of ethanol in blood, reduces mda content and can improve glutathione peroxidase activity.

Fructus amomi (Amomi Semen) is the dry mature fruit of zingiberaceous plant amomum viosum Amomum villosum Lour., green shell sand Amomum villosum Lour.var.xanthioides T.L.Wu et Senjen or SEMEN AMOMI LONGILIGULA Amomum longiligulare T.L.Wu.Taste is pungent, warm in nature.Return spleen, stomach, kidney channel.Dampness elimination is had to whet the appetite, warming spleen and stopping diarrha, antiabortive function of regulating the flow of vital energy.Research finds, fructus amomi contains volatile oil, soaping agents, flavonoid glycoside, organic acid and inorganic constituents.To digestive system, immune system and nervous system, there is definite curative effect, also there is the effects such as anti-inflammatory, cholagogic and analgesia.Pharmacological tests shows, fructus amomi is to water logging stress ulcer, and the gastric mucosal cell obstacle that the acute gastric mucosal lesion that hydrochloric acid causes, indoles cause by a pungent ethanol has obvious inhibitory action.Zhu Jinzhao etc. are tested by rat in vivo, and find that fructus amomi Aqueous extracts promotes the equal highly significant of effect of gastric emptying and enteron aisle transmission, its small intestinal transit and Cisapride have certain comparativity.And tentatively illustrate the short gastroenteritic power mechanism of fructus amomi: after rats gavaged fructus amomi aqueous extract, gastroenteritic power significantly strengthens, and in blood plasma, stomach hole and jejunal tissue, motilin (MTL), Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 (SP) content obviously increase.

Poria cocos (PORIA) is the dry sclerotia of On Polyporaceae Poria cocos Poria cocos (Schw.) Wolf., and property is put down, and taste is sweet, light.The thoughts of returning home, lung, spleen, kidney channel.Be one of Chinese medicine " four monarch's eight delicacies ", Shennong's Herbal is classified as top grade.There is effect of eliminating dampness and diuresis, the peaceful heart of invigorating the spleen.For oedema oliguria, phlegm and retained fluid is dizzy throbs with fear, and insufficiency of the spleen food is few, has loose bowels in loose stool, confused and worried, and palpitation with fear insomnia waits card.Research finds, hydroxyl pachymaran (Carboxymethylpachymaran, CMP) is one of active component of Poria cocos, and show through modern pharmacology test, CMP is to alcohol and CCl ₄the Mouse Liver infringement caused has protective effect, and serum glutamic pyruvic transaminase can be made significantly to reduce, and the liver regeneration ability of the rat that hepatic portion can also be made to excise improves, and Liver Regeneration ratio that is heavy and body weight increases.

The fresh rhizome that ginger (Zingiber officinale Roscoe) is ginger ginger Zingiber officinale Rosc..Taste is pungent, tepor.Return lung, stomach, the spleen channel.There is loose trembling with fear of inducing sweat, warming middle energizer to arrest vomiting, the function of preventing phlegm from forming and stopping coughing.Pharmacology test shows: ginger decoction is two-way function to hydrochloric acid in gastric juice and stomachial secretion, namely just then suppresses and follow-up with the excitement of long period.And have nerve ending town to tell effect.And can gastric mucosa be protected, prevention mouse stress gastric ulcer.The people such as Wang Jinhua find that ginger decoction significantly can suppress the vomiting number of times of pigeon, reduce vomiting number of elements, have significant antipyretic effect to pyrogenicity rat.

The dry mature skin that dried orange peel (Pericarpium Citri Reticulatae) is rutaceae orange Citrus reticulata Blanco and variety thereof.Bitter, pungent, warm in nature.Return spleen, lung channel.There is regulating qi-flowing for strengthening spleen, eliminating dampness and eliminating phlegm function.Containing volatile oil and flavone compound in dried orange peel.Pharmaceutical research confirms, dried orange peel Aqueous extracts has obvious facilitation in vitro salivary amylase activity; Dried orange peel water decoction can promote progradation and the gastric emptying of mouse small intestine, improves the digestive function of small intestine; And there is remarkable impact to domesticated dog Lipid Secretion in Primary Culture of Hepatocytes, the ratio of cholesterol in secretion and cholesterol saturation index (CSI) can be made significantly to decline.Disappointing function that it is soothing the liver is relevant with promotion choleresis; The test of the people such as Zhang Xiongfei shows, with dried orange peel extracts in advance gavage mouse obviously can extend the time of drunk generation, shorten and sober up the time, reduce the death rate of mouse, and mice serum concentration of alcohol can be reduced, improve alcohol dehydrogenase (ADH) content, recover hepatic tissue GSH-PX activity sulfurtransferase (GST) active, improve the content of reduced glutathione (GSH).Thus to alcoholic liver, there is protective effect.

In this formula, wine heat poison in hoveniae semoveniae semen, root of kudzu vine solution, is monarch drug in a prescription in side; Fructus amomi is removed dampness by means of aromatics, promoting the circulation of qi of relieving the effect of alcohol; Poria cocos has inducing diuresis with bland drug, invigorating the spleen of sobering up; Ginger relieves the effect of alcohol and stomach, heat-clearing and damp-drying drug; Dried orange peel is regulated the flow of vital energy in tune, stopping nausea and vomiting by lowering the adverse flow of QI, and all medicines share, and the feasible point of wine that disappears wets, the merit that clearing liver cholagogic is damp and hot.

The invention has the advantages that: the promoting digestion and protecting liver food that the invention belongs to pure natural, security is high, and technique is simple, and mouthfeel is better, and taking convenience, is easy to carry and preserves.

Detailed description of the invention:

The following examples can make the present invention of those skilled in the art's comprehend, but do not limit the present invention in any way.

Example 1 promoting digestion and protecting liver product and production process thereof.

A kind of promoting digestion and protecting liver product, according to listed as parts by weight, by the root of kudzu vine 90 parts, hoveniae semoveniae semen 50 parts, fructus amomi 20 parts, 60 parts, Poria cocos, 10 parts, ginger, dried orange peel 20 parts, 50 parts, sweet mellow wine, dolomol 0.7 part is made, production method comprises the steps: the root of kudzu vine first selecting dried and clean, hoveniae semoveniae semen, fructus amomi, Poria cocos, ginger, dried orange peel is pulverized, make the material particular diameter after pulverizing at about 2cm, mixing after weighing, subsequently by mixed material and water with 1: 8 weight ratio mix, boil, then keep micro-to boil 1 hour, then filter obtain filtrate collect stand-by, to expect that slag and the water weight ratio with 1: 6 mixes subsequently, boil, then keep micro-to boil 40 minutes, subsequently after filtration or centrifugally obtain filtrate, after filtrate being merged, concentrated, be spray dried to powder, for subsequent use, 80 mesh sieves crossed by sweet mellow wine, mix with xeraphium, obtain softwood with 50% ethanol, granulate with 18 mesh sieves, dry, control pellet moisture and be less than 5%, whole grain, adds dolomol, flavoring essence, always mixes, compressing tablet.

Example 2 promoting digestion and protecting liver product and production process thereof.

A kind of promoting digestion and protecting liver product, according to listed as parts by weight, by the root of kudzu vine 100 parts, hoveniae semoveniae semen 100 parts, fructus amomi 30 parts, 50 parts, Poria cocos, 5 parts, ginger, dried orange peel 10 parts, 50 parts, sweet mellow wine, microcrystalline cellulose 25 parts, dolomol 0.7 part, flavoring essence 0.35 part is made, production method comprises the steps: the root of kudzu vine first selecting dried and clean, hoveniae semoveniae semen, fructus amomi, Poria cocos, ginger, dried orange peel Six-element medicine materical crude slice, mixing after weighing, subsequently by mixed material and water with 1: 15 weight ratio mix, boil, then keep micro-to boil 1.5 hours, then filter obtain filtrate collect stand-by, to expect that slag and the water weight ratio with 1: 8 mixes subsequently, boil, then keep micro-to boil 1 hour, subsequently after filtration or centrifugally obtain filtrate, after filtrate being merged, be condensed into medicinal extract, for subsequent use, microcrystalline cellulose, sweet mellow wine cross 80 mesh sieves respectively, join in medicinal extract, mixing, obtained softwood, granulates with 18 mesh sieves, dry, controls pellet moisture and is less than 5%, whole grain, adds dolomol, flavoring essence, always mixes, compressing tablet.

Claims (2)

1. there is a product for promoting digestion and protecting liver function, it is characterized in that: the preparation be made up of the stock and adjunct of following portions by weight ratio;

Described raw material is: the root of kudzu vine 50 ~ 100 parts, hoveniae semoveniae semen 50 ~ 100 parts, fructus amomi 10 ~ 50 parts, 50 ~ 100 parts, Poria cocos, 5 ~ 20 parts, ginger, dried orange peel 10 ~ 50 parts,

Described auxiliary material is: 50 ~ 100 parts, sweet mellow wine, dolomol 0.5 ~ 5 part, flavoring essence 0.1 ~ 1 part;

The described product with promoting digestion and protecting liver function is prepared by the following method:

By the root of kudzu vine 50 ~ 100 parts, hoveniae semoveniae semen 50 ~ 100 parts, fructus amomi 10 ~ 50 parts, 5 ~ 20 parts, ginger, dried orange peel 10 ~ 50 parts, the pulverizing of 50 ~ 100 parts, Poria cocos, boiling twice, first time adds 8 ~ 15 times of water gagings by weight, micro-decoction 1 ~ 2 hour of boiling, second time adds 6 ~ 10 times of water gagings, micro-decoction 0.5 ~ 1 hour of boiling by weight, collecting decoction, filters, concentrated, spraying dry, adds auxiliary material, through granulating, drying, whole grain, always mixes, compressing tablet, makes masticatory pattern oral formulations.

2. a preparation technology with the product of promoting digestion and protecting liver function according to claim 1, it is characterized in that: the root of kudzu vine, hoveniae semoveniae semen, fructus amomi, ginger, dried orange peel, Poria cocos are pulverized, boiling twice, first time adds 8 ~ 15 times of water gagings, micro-decoction 1 ~ 2 hour of boiling by weight, and second time adds 6 ~ 10 times of water gagings by weight, micro-decoction 0.5 ~ 1 hour of boiling, collecting decoction, filters, concentrated, spraying dry, add auxiliary material, through granulating, dry, whole grain, total mixed, compressing tablet, makes masticatory pattern oral formulations.