CN103370311A - 用于治疗HSP90相关病状的Pochoxime缀合物 - Google Patents

用于治疗HSP90相关病状的Pochoxime缀合物 Download PDF

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CN103370311A
CN103370311A CN2011800601830A CN201180060183A CN103370311A CN 103370311 A CN103370311 A CN 103370311A CN 2011800601830 A CN2011800601830 A CN 2011800601830A CN 201180060183 A CN201180060183 A CN 201180060183A CN 103370311 A CN103370311 A CN 103370311A
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cancer
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N.温辛格
S.巴鲁恩嘉
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Centre National de la Recherche Scientifique CNRS
Universite de Strasbourg
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Universite de Strasbourg
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CN2011800601830A 2010-10-22 2011-10-24 用于治疗HSP90相关病状的Pochoxime缀合物 Pending CN103370311A (zh)

Priority Applications (1)

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CN201611152551.5A CN107011311A (zh) 2010-10-22 2011-10-24 用于治疗HSP90相关病状的Pochoxime缀合物

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US40588210P 2010-10-22 2010-10-22
US61/405,882 2010-10-22
PCT/IB2011/002796 WO2012052843A1 (en) 2010-10-22 2011-10-24 Pochoxime conjugates useful for the treatment of hsp90 related pathologies

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CN201611152551.5A Division CN107011311A (zh) 2010-10-22 2011-10-24 用于治疗HSP90相关病状的Pochoxime缀合物

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CN2011800601830A Pending CN103370311A (zh) 2010-10-22 2011-10-24 用于治疗HSP90相关病状的Pochoxime缀合物
CN201611152551.5A Pending CN107011311A (zh) 2010-10-22 2011-10-24 用于治疗HSP90相关病状的Pochoxime缀合物

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US (3) US20140031302A1 (https=)
EP (1) EP2630132A1 (https=)
JP (2) JP2013543840A (https=)
KR (1) KR20140021520A (https=)
CN (2) CN103370311A (https=)
AU (1) AU2011319685B2 (https=)
BR (1) BR112013009614A2 (https=)
CA (1) CA2812320A1 (https=)
IL (1) IL225371A0 (https=)
RU (1) RU2013122898A (https=)
WO (1) WO2012052843A1 (https=)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140079636A1 (en) 2012-04-16 2014-03-20 Dinesh U. Chimmanamada Targeted therapeutics
EP3738594A1 (en) 2013-09-10 2020-11-18 Madrigal Pharmaceuticals, Inc. Targeted therapeutics having an hsp90 ligand as binding moiety
WO2015066053A2 (en) 2013-10-28 2015-05-07 Synta Pharmaceuticals Corp. Targeted therapeutics
EP3099332A4 (en) 2014-01-29 2017-06-21 Madrigal Pharmaceuticals, Inc. Targeted therapeutics
JP6576942B6 (ja) 2014-03-03 2019-11-27 マドリガル ファーマシューティカルズ インコーポレイテッド 標的治療薬
MA39483A (fr) 2014-03-18 2015-09-24 Synta Pharmaceuticals Corp Agents thérapeutiques cibles
PL3292116T3 (pl) 2015-02-02 2022-02-21 Valo Health, Inc. 3-arylo-4-amidobicykliczne kwasy [4,5,0]hydroksamowe jako inhibitory hdac
TW201636329A (zh) 2015-02-02 2016-10-16 佛瑪治療公司 作為hdac抑制劑之雙環[4,6,0]異羥肟酸
EP3472131B1 (en) 2016-06-17 2020-02-19 Forma Therapeutics, Inc. 2-spiro-5- and 6-hydroxamic acid indanes as hdac inhibitors
KR20200016874A (ko) 2017-06-20 2020-02-17 마드리갈 파마슈티칼스 인코포레이티드 표적화 치료제를 포함하는 병용 요법
CA3067572A1 (en) 2017-06-20 2018-12-27 Madrigal Pharmaceuticals, Inc. Targeted therapeutics
WO2022082108A1 (en) * 2020-10-16 2022-04-21 The Brigham And Women's Hospital, Inc. Compositions for inducing tumor immunity and reducing drug tolerance
CN119424412A (zh) * 2024-12-04 2025-02-14 中国药科大学 以prdx1作为药物靶标的天然抑制剂在制备抗乳腺癌药物中的应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009091921A1 (en) * 2008-01-15 2009-07-23 Universite De Strasbourg Synthesis of resorcylic acid lactones useful as therapeutic agents

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5861156A (en) * 1993-01-08 1999-01-19 Creative Biomolecules Methods of delivering agents to target cells
US5624677A (en) 1995-06-13 1997-04-29 Pentech Pharmaceuticals, Inc. Controlled release of drugs delivered by sublingual or buccal administration
AU722492B2 (en) * 1996-08-30 2000-08-03 University Of Hawaii Pharmaceutical compounds
WO1998025934A1 (en) * 1996-12-13 1998-06-18 Kyowa Hakko Kogyo Co., Ltd. Dc 107 derivatives (2)
AU2001271567A1 (en) 2000-06-29 2002-01-14 Trustees Of Boston University Use of geldanamycin and related compounds for prophylaxis or treatment of fibrogenic disorders
ITRM20010079A1 (it) * 2001-02-16 2002-08-16 Sigma Tau Ind Farmaceuti Amminoderivati della biotina e loro coniugati con chelanti macrociclici.
TWI381852B (zh) * 2005-09-27 2013-01-11 Sigma Tau Ind Farmaceuti 生物素二胺基衍生物類及其與大環螯合劑之共軛物
US8329683B2 (en) * 2006-06-02 2012-12-11 Nexgenix Pharmaceuticals, Llc Treatment of neurofibromatosis with radicicol and its derivatives
JP5465006B2 (ja) * 2006-08-11 2014-04-09 ユニベルシテ・ドウ・ストラスブール キナーゼおよびhsp90の阻害剤として有用な大環状化合物
CN102015673B (zh) * 2008-02-21 2014-10-29 昂科协同公司 用作治疗剂的大环前药化合物

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009091921A1 (en) * 2008-01-15 2009-07-23 Universite De Strasbourg Synthesis of resorcylic acid lactones useful as therapeutic agents

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SOFIA BARLUENGA, ET AL.: "Inhibition of HSP90 with Pochoximes: SAR and Structure-Based Insights", 《CHEMBIOCHEM》 *

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BR112013009614A2 (pt) 2016-07-19
CA2812320A1 (en) 2012-04-26
JP2017039730A (ja) 2017-02-23
US20150374680A1 (en) 2015-12-31
AU2011319685A1 (en) 2013-04-11
KR20140021520A (ko) 2014-02-20
US20140031302A1 (en) 2014-01-30
CN107011311A (zh) 2017-08-04
WO2012052843A1 (en) 2012-04-26
JP2013543840A (ja) 2013-12-09
RU2013122898A (ru) 2014-11-27
US20170174669A1 (en) 2017-06-22
AU2011319685B2 (en) 2016-02-04
IL225371A0 (en) 2013-06-27
EP2630132A1 (en) 2013-08-28

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