CN103348990A - Bactericidal composition containing mandipropamid and captan - Google Patents
Bactericidal composition containing mandipropamid and captan Download PDFInfo
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- CN103348990A CN103348990A CN2013103234247A CN201310323424A CN103348990A CN 103348990 A CN103348990 A CN 103348990A CN 2013103234247 A CN2013103234247 A CN 2013103234247A CN 201310323424 A CN201310323424 A CN 201310323424A CN 103348990 A CN103348990 A CN 103348990A
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Abstract
The invention provides a bactericidal composition containing mandipropamid and captan, and relates to a bactericidal composition which adopts mandipropamid and captan as active ingredients and is used for preventing grain, fruit, vegetables, flower, lawn and industrial crops from harmful bacteria. The bactericidal composition containing mandipropamid and captan comprises active components of mandipropamid and captan, and the weight ratio of mandipropamid and captan is (1:100)-(100:1). According to the invention, mandipropamid and captan are subject to binary formulation, so that the obtained bactericidal composition has an enhanced control effect, expands a bacteriocidal spectrum and takes multiple effects. Moreover, as mandipropamid and captan have different functions mechanisms, the disease prevention effect can be improved and germs have low probability of resistance to drugs.
Description
Technical field
A kind of bactericidal composition that contains mandipropamid and captan of the present invention relates to is that a kind of mandipropamid (mandipropamid) and captan (Captan) of comprising is as the bactericidal composition of active component.The invention still further relates to a kind of bactericidal composition that comprises mandipropamid and captan and prevent and treat the purposes of the germ harm of cereal, fruit, vegetables, flowers, lawn, economic crops.
Background technology
In horticultural crop and dry-land crop production, crop can run into multiple fungi or infecting of bacterium and various diseases, also often because of in the soil multiple cause a disease or saprophytic fungi (mould such as corruption, epidemic disease is mould, Rhizoctonia solani Kuhn, sickle-like bacteria, botrytis cinerea etc.) and bacterium (soft-rot fungi etc.) infect harm, cause mashed kind, mashed root, seedling extremely.
Mandipropamid (mandipropamid), its chemical name is: (RS)-N-2-(4-chlorphenyl)-N-[2-(3-methoxyl group-4-propine-2-base oxygen base phenyl) ethyl]-2-propine-2-base oxygen yl acetamide, its structural formula is:
Mandipropamid is novel mandelamide type Oomycete disease bactericide.Its mechanism of action all has good preventive effect to large absolutely number by ovum microbial leaf section and fruit disease for suppressing the biosynthesis of phosphatide.The spore that is in the sprouting stage is had higher activity, and can suppress mycelia and grow up and sporulation.Can be rapidly absorbed by blade, and rest in the leaf table wax coat, blade is shielded.Mandipropamid has good control efficiency to tomato late blight and cucumber downy mildew, Oomycete disease to other vegetable crop has good control efficiency too, and for example: downy mildew of lettuce, spinach and capsicum and Phytophthora capsici cucurbitaceous that mustard vegetables such as Chinese cabbage downy mildew, lettuce castor belong to are sick.
Captan (captan), the Chinese another name is called Gai Pudan, and its chemical name is: N-(trichloro-methylthio)-hexamethylene-4-alkene-1,2-dicarboximide; 1,2,3,6-tetrahydrochysene-N-(trichloro-methylthio) phthalimide, its structural formula is:
Captan is a kind of organic sulfur class broad spectrum activity low toxicity bactericide; take protective effect as main, have certain therapeutic action concurrently, use safer; many kinds of fungal diseases on the various crop are all had good preventive effect, be specially adapted to the crop to copper agent agricultural chemicals sensitivity.This medicine is permeable to the cell membrane of germ, not only can disturb germ respiratory, but also can disturb its cell division, have a plurality of bactericidal actions site, continuous several times uses extremely difficulty to induce germ to develop immunity to drugs, it is more obvious to spray continuously protection effect.It mainly makes spray application, also can make seed treatment, dips product after the results, carries out soil treatment before the sowing or before planting.Generally with 0.1% left and right sides concentration liquid spraying, the downy mildew of control fruit tree, vegetables, flowers and other economic crops etc., downy mildew, powdery mildew, anthracnose, gray mold, early blight, late blight etc.The 0.3-0.5% that presses seed weight processes seed, can prevent and treat Cereal smut, disease in cotton seedling stage etc.The activity of this compound is good, and still, it is sometimes also unsatisfactory when low rate of application.
Summary of the invention
The objective of the invention is for solving above-mentioned at least one problem or its at least one aspect, in particular for effectively controlling plant disease, and/or reduce cost or application dosage, through the large number of biological test screen, provide a kind of bactericidal composition that contains mandipropamid and captan and uses thereof.
The present invention relates to a kind of bactericidal composition that contains mandipropamid and captan.
A kind of bactericidal composition that contains mandipropamid and captan of the present invention and uses thereof is to take following technical scheme to realize:
A kind of bactericidal composition that contains mandipropamid and captan is characterized in that containing active component mandipropamid and captan.
The present invention is a kind of to contain that mandipropamid and captan are the Synergistic effective dosies in the bactericidal composition of mandipropamid and captan, the weight proportion that the present invention is a kind of to contain active component mandipropamid described in the bactericidal composition of mandipropamid and captan and captan is that 1:100 is to 100:1, preferred 1:50-50:1, preferred 1:20-20:1 again, more preferably 1:10-10:1, most preferably 1:5-5:1.
In a kind of bactericidal composition that contains mandipropamid and captan of the present invention, the weight percentage that described active component mandipropamid and captan account for composition is 5-90%, preferred 10%-80%, more preferably 20%-60%.
In described a kind of bactericidal composition that contains mandipropamid and captan, described active component mandipropamid and captan mix with liquid or solid carrier and/or surfactant.
Above-mentioned a kind of bactericidal composition that contains mandipropamid and captan of the present invention can only comprise active ingredient, also can mix together with additive, therefore a kind of bactericidal composition that contains mandipropamid and captan of the present invention can be prepared into various formulations, and the formulation of described bactericidal composition is suspending agent, plants clothing agent, wetting powder, water dispersible granules, micro-capsule granules, paste, aerosol, ZC, coated granule, extrudes granule, missible oil, microemulsion, aqueous emulsion, effervescent tablet.
A kind of bactericidal composition that contains mandipropamid and captan is characterized in that: also comprise one or more other active components.
A kind of bactericidal composition that contains mandipropamid and captan of the present invention is used for preventing and treating cereal, fruit, vegetables, flowers, lawn, economic crops.
The bactericidal composition that the present invention is a kind of to contain mandipropamid and captan is for the protection of the purposes of plant propagation material and the plant organ that grows subsequently.
The place control soil that the bactericidal composition that a kind of usefulness of the present invention contains mandipropamid and captan is applied to required control causes a disease or the purposes of saprophytic fungus and bacterium.
Detailed Description Of The Invention
The invention provides a kind of bactericidal composition with synergistic function that contains mandipropamid and captan.
The present invention creatively unites two into one mandipropamid and captan, not only can prevent and treat the germ harm of cereal, fruit, vegetables, flowers, lawn, economic crops, can also doublely control the fungus and bacterium disease in the soil, it is multiplex to have a medicine, widens the diseases prevention spectrum.And be used for soil treatment or soak (mixing) kind, mashed kind, the mashed root that can prevent soil disease to cause ensure full stand, alleviate sprout term disease, better effects if.
The invention provides a kind of bactericidal composition that contains mandipropamid and captan.
Concrete scheme of the present invention is: a kind of bactericidal composition that contains active component mandipropamid and captan is comprised of following component: the suspending agent that mandipropamid, captan bactericide and insecticides adjuvant form, plant clothing agent, wetting powder, water dispersible granules, micro-capsule granules, paste, aerosol, ZC, coated granule, extrude granule, missible oil, microemulsion, aqueous emulsion, effervescent tablet.
Mandipropamid bactericide and captan bactericide are the Synergistic effective dosies in the composition of the present invention, the weight ratio of compound mandipropamid and captan is 1:100-100:1 in the present composition, preferred 1:50-50:1, preferred 1:20-20:1 again, more preferably 1:10-10:1, most preferably 1:5 is to 5:1.
Active component mandipropamid and captan bactericide account for the 5-90% of composition in the composition of the present invention, preferred 10%-80%, more preferably 20-60%.
Above-mentioned composition of the present invention can only comprise active ingredient, also can mix together with additive, therefore composition of the present invention can be prepared into various formulations, the liquor that forms such as mandipropamid, captan bactericide and insecticides adjuvant, wetting powder, water dispersible granules, suspending agent, the agent of kind clothing, aerosol, coated granule, effervescent tablet, aqueous emulsion, microemulsion etc.According to the character of these compositions and use purpose and the ambient conditions that composition will reach, can select composition is used with spraying, immersion, atomizing, the method for broadcasting sowing, pour, filling with root etc. and so on.
Can produce these preparations by known method.For example, in the situation of selectively using surfactant, by being mixed with filler, reactive compound prepares preparation, and described filler is the diluent or carrier of liquid or liquid gas or solid, said surfactant is emulsifier, dispersant, wetting agent.In the situation of water as filler, also can with an organic solvent, for example, organic solvent be used as cosolvent.
According to the present invention, term " carrier " refer to can be with reactive compound combined or associating so that it is easier to be administered to the natural or synthetic organic or inorganic compound of object (for example plant, crop or careless class).Therefore, described carrier is preferably inertia, and it is acceptable to should be at least agricultural.Described carrier can be solid or liquid.
Operable nonactive medium both can be that solid also can be liquid among the present invention, can be used as for example having that the solid media material uses: the phyteral powdery type (particle of soybean meal, starch, grain dust, wood powder, bark powder, sawdust, walnut shell powder, wheat bran, cellulose powder, coconut husk, corncob and tobacco stem for example, extract residue behind the plant essence etc.), paper, sawdust, pulverize synthesized polymer body, clay class (such as kaolin, bentonite, acid china clay etc.), the talcum powder class of synthetic resin etc.Silica (for example diatomite, silica sand, mica, moisture silicic acid, calcium silicates), chemical fertilizer, the clay fertilizer of active carbon, natural mineral matter class (float stone, attapulgite and zeolite etc.), the inorganic mineral powder of firing diatomite, sand, plastics medium etc. (such as polyethylene, polypropylene, polyvinylidene chloride etc.), potassium chloride, calcium carbonate, calcium phosphate etc., ammonium sulfate, ammonium phosphate, urea, greening ammonium etc., these materials can use separately or use with more than 2 kinds.
Can be used as can in following material, selecting of liquid media materials'use, water for example, alcohol type (methyl alcohol for example, ethanol, isopropyl alcohol, butanols, ethylene glycol etc.), ketone (acetone for example, methyl ethyl ketone, isobutyrone, cyclohexanone etc.), ethers (ether for example, dioxanes, methylcellulose, oxolane etc.), aliphatic hydrocarbon class (kerosene for example, the mineral wet goods), aromatic hydrocarbons class (benzene for example, toluene, dimethylbenzene, solvent naphtha, Fluhyzon, chlorinated aromatic hydrocarbons, chlorinated aliphatic hydrocarbon, chlorobenzene, etc.), the halogenated hydrocarbon class, amide-type, the sulfone class, dimethyl sulfoxide (DMSO), mineral and vegetable oil, the animal wet goods.
As other adjuvants can come choice for use according to application target, also can use separately, some occasion more than 2 kinds adjuvant share, or some occasion can not used adjuvant fully.For making the emulsification of active ingredient compound; disperse; solubilization; and/or the wetting surfactant that can use for example can be enumerated fatty alcohol-polyoxyethylene ether; polyoxyethylene alkylaryl ether; the polyoxyethylene high-grade aliphatic ester; the phosphate of polyoxyethylene alcohol or phenol; the fatty acid ester of polyalcohol; the alkane aromatic sulfonic acid; the naphthalene sulfonic acids polymer; lignosulfonates; a dress copolymer of macromolecule comb shape; butyl naphthalene sulfonate; alkylaryl sulfonates; the alkyl sodium sulfosuccinate; grease; fatty alcohol and ethylene oxide condensate; the polyacrylates such as alkyltaurate; protein hydrolysate.Suitable oligosaccharide thing or polymer are for example based on the combination of independent vinyl monomer, acrylic acid, EO and/or PO or itself and for example (polynary) alcohol or (polynary) amine.
For making active ingredient compound decentralized stabilization, adhering to and/or combination, can use such as adjuvants such as xanthans, aluminium-magnesium silicate, gelatin, starch, methyl cellulose, polyvinyl alcohol, polyvinyl acetate and natural phospholipid (such as cephalin and lecithin) and synthetic phospholipid, bentonite, sodium lignin sulfonates.
The optional spent glycol of antifreezing agent wherein, propane diols, glycerine, sorbierite.Can use adjuvant such as naphthalene sulfonic acids polymer, polymeric phosphate etc. as the deflocculant of suspension product.
Defoamer can use silicone defoaming agent.
Operable colouring agent, inorganic pigment for example is such as iron oxide, titanium oxide and Prussian blue; And organic pigment/dyestuff: alizarin dyes, azo dyes and metal phthalocyanine dyestuff; And trace element, for example molysite, manganese salt, boron salt, mantoquita, cobalt salt, molybdenum salt and zinc salt.
Randomly, also can comprise other annexing ingredient, for example protecting colloid, adhesive, thickener, thixotropic agent, bleeding agent, stabilizing agent, screening agent.
Described a kind of formulation that contains the composition pesticide of mandipropamid and captan is: aerosol, suspending agent, the micro-capsule granula, granula subtilis, concentrate can flow, the ready to use solution agent, pulvis, aqueous emulsion, oil emu, fine granule, the oil dispersion powder, the miscible mobile concentrate of oil, the miscible liquid of oil, foaming agent, paste, suspending concentrate, suspension emulsion, solubility concentrates thing, soluble powder, granule, water-soluble granular and/or tablet, water solube powder, wetting powder, natural or synthetic material through the reactive compound dipping, microcapsules in the polymeric material and water-dispersible granule.In preferred embodiments, described composition pesticide is suspending agent, water dispersible granules, wetting powder, suspension emulsion and/or microcapsule suspending agent.
Described preparation of the present invention can mix described reactive compound by known way and prepare with conventional additives.Described conventional additives such as conventional extender and solvent or thinner, emulsifier, dispersant and/or adhesive or fixative, wetting agent, waterproofing agent, if necessary, can also comprise drier and colouring agent, stabilizing agent, pigment, defoamer, preservative, thickener, water and other processing aid.
These compositions not only comprise and can be applicable to immediately pending object such as spraying or dusting equipment by suitable equipment, are applied to the concentrated commercial composition that need dilute before the object but also be included in.
Composition of the present invention can be made the preparation that is suitable for using with the form of the composition of its active compound component, also can use with the form of the combination of the commodity preparation of its suitable dosage.
Composition of the present invention can also be co-administered with other active component, such as fungicide, bactericide, attractant, insecticide, miticide, nematocide, growth regulator, weed killer herbicide, safener, fertilizer or semiochemical etc. of described other active component.
Composition of the present invention or combination can also be presented as the form of kit, and it comprises mandipropamid and captan.On the other hand, the invention still further relates to the germ harm that described kit is used for preventing and treating cereal, fruit, vegetables, flowers, lawn, economic crops.The invention still further relates to described kit for the protection of plant propagation material and the plant organ that grows subsequently.The invention still further relates to the pathogenic or saprophytic fungus and bacterium of place control soil that described kit is applied to required control.
Described a kind of composition pesticide that contains mandipropamid and captan is used for preventing and treating cereal, fruit, vegetables, flowers, lawn, economic crops.Common germ has stem canker, leaf rust, smut, bunt, rust, stem rot, gray mold, southern blight, anthracnose, bud rot, Brown patch disease, huge pinta, fairy ring, red thread, false smut, spot defoliation, leaf spot, epidemic disease, head blight, downy mildew, banded sclerotial blight, powdery mildew, phytophthora rot, anthracnose, brown spot, tar spot, balck shank, soft rot, canker, purple spot, damping off, stem wilt, damping off, the seedling epidemic disease, leaf blight, rust, black spot, scab.
Can use the useful plant of bactericidal composition of the present invention to comprise a lot, for example: paddy rice, peanut, cotton, beet, potato, lawn, wheat, barley, cucumber, grape, mango, wax-apple, strawberry, apple, banana, tomato, sunflower, pears, potato, corn, pear tree, coffee, ornamental plants class.
Described a kind of composition pesticide that comprises mandipropamid and captan is used for multiple causing a disease or the purposes of saprophytic fungus and bacterium in prevention or the control soil.The example of soilborne fungoid disease substance comprises Alternaria (Alternaria spp.), Ascochyta (Ascochyta spp.), Botrytis cinerea (Botrytis cinerea), Cercospora (Cercospora spp.), ergot (Claviceps purpurea), standing grain cochliobolus (Cochliobolus sativus), Colletotrichum (colletotrichum spp.), Epicoccum (Epicoccum spp.), F.graminearum schw (Fusarium graminearum), rice is disliked seedling chain spore (Fusarium moniliforme), fusarium oxysporum (Fusarium oxysporum), fusarium moniliforme (Fusarium proliferatum), fusariun solani (Fusarium solani), dimension glue chain spore (Fusarium subglitinans), Helminthosporium (Helminthosporium spp), avenge rotten microtorr bacterium (Microdochium nivale), Penicillium (Pencillium spp), Phoma (Phoma spp.), wheat class nuclear cavity bacteria (Pyrenophora graminea), rice blast Pyricularia Sacc. (Pyricularia oryzae), Rhizoctonia solani Kuhn (Rhizoctonia solani), Rhizoctonia cerealis (Rhizoctonia cerealis), Sclerotinia (Sclerotinia spp.), Septoria (Septoria spp.), silk axle smut (Sphacelotheca reilliana), Tilletia (Tilletia spp.), meat spore nuclear coral bacterium (Typhula incarnate), hidden smut (Urocystis occulta), Ustilago (Ustilago spp.) or Verticillium (Verticillium spp.).
The soil germ has rhizoctonia solani, sickle-like bacteria, pythium spp, phytophthora, the bacterium of dampinging off, root rot, pythium spp, botrytis cinerea, soft-rot fungi etc.In the ordinary course of things, the soil germ can produce a large amount of thalline, the host is susceptible as long as condition is grown favourable to pathogen growth, germ just can also can be infected the host by amount reproduction, in the presence of susceptible host, these germs just can enter the lasting pathogenic phase, the amount reproduction diffusion along with the continuous cropping of crop, but nutrient has been consumed or soil condition such as temperature, humidity etc. when unfavorable to germ afterwards, and germ can enter resting stage again.When susceptible host does not exist, under the soil-borne disease bacterium also can survive in soil, except the soil germ has widely host range, can also survive root surface or the broken branches and fallen leaves of non-host, have saprophytic competitive ability with it and be undivided.But different germs are discrepant, almost can survive indefinite duration in soil as sickle-like bacteria.
The soil of said plant or cultivation medium refer to the supporter that can make crops take root, grow when using method of the present invention is implemented, for example: soil, water etc., concrete raw material can use such as sand, float stone, vermiculite, diatomite, agar-agar, gelling material, polymer substance, asbestos, wood chip, bark etc.
Use the method for medicament in the soil, for example be diluted in liquid preparation in the water or do not dilute the root that directly is applied to plant corpus or the medium method in rice seedling bed that seedling is used, method in the rice seedling bed of the root of plant corpus or seedling that granule is disseminated to have prior to seeding pulvis, water dispersible granules etc. is sprayed in the soil and with the whole method of mixing of soil, to be sprayed in implantation hole, the seed furrow behind pulvis, the water-dispersible grain dilution agent before the sowing or before the serike body, in the method for sowing etc.
Described a kind of composition pesticide that comprises mandipropamid and captan is for the protection of the purposes of plant propagation material and the plant organ that grows subsequently.
Term " plant propagation material " is interpreted as the plant part that refers to that all have fertility, seed for example, and it can be used for the breeding latter, and vegetable matter for example cuttage bar or stem tuber (for example potato).Therefore, plant part used herein comprises plant propagation material.What can mention is seed (narrowly) for example, root, fruit, stem tuber, bulb, rhizome and plant part.Germination plant and effective plant until germinate from soil rear or the rear inhibition of emerging also can be mentioned.Immature plant can be undertaken all by dipping before transplanting or Local treatment is protected.
Plant part and the plant organ that grows subsequently are for example any parts of the plant of seed generation of oily plant propagation material.Plant part, plant organ and plant also can be benefited from the cause of disease infringement protection that obtains by composition pesticide being applied to plant propagation material.In embodiment, the plant organ that grows behind certain plants part and some place also can be regarded plant propagation material as, himself can use with composition pesticide (or processing); Thereby also can be benefited from the cause of disease infringement protection that obtains by composition pesticide being applied to certain plants part and certain plants organ by plant, other plant part and other plant organ that treated plant part and treated plant organ produce.
Preferably, propagating materials is seed, the method of seed treatment, for example can enumerate, the medicament of diluent liquid or solid shape or need not dilute directly is immersed in seed the method that makes medicament soak into seed in the liquid condition solution, solid chemicals or liquid preparation is mixed with seed, carries out Cotton seeds and makes the surface of the seed adhere to the method for medicament, the method such as sprays when planting near seed.
Method of the present invention also provides with separately, successively or the co-administered described reactive compound of simultaneous system.In one embodiment, use simultaneously mandipropamid and captan.In another embodiment, use successively mandipropamid and captan.In another embodiment, separate administration mandipropamid and captan.
In a preferred embodiment, method of the present invention comprises that the present composition that will comprise mandipropamid and captan is administered to object.
Bactericidal composition of the present invention can be made into common medicament form, medicament forms such as missible oil, wetting powder, suspending agent, liquor, granule, the agent of kind clothing is used, its amount of application, according to mixing ratio, meteorological condition, the medicament form of active ingredient, use period, application process, use the place, prevent and kill off the target pest, the difference of target crops etc. and variant:
-usually process for leaf section: 0.1-10000g/ha, preferred 10-1000 g/ha, more preferably 50-300 g/ha; For dipping or instil use for, described dosage even can also reduce is particularly when using inert base such as asbestos or pearl rock;
-for seed treatment: 2-200 g/100kg seed, preferred 3-150 g/100kg seed;
-for soil treatment: 0.1-10000 g/ha, preferred 1-5000 g/ha.
Above-mentioned dosage only is general exemplary dose, and those skilled in the art can according to actual conditions and needs, especially adjust rate of application according to the character of pending plant or crop and the seriousness of germ during actual using.
Should be pointed out that on the meaning of the present invention that term " mandipropamid and captan combination/associating " comprises and separates, uses successively or simultaneously mandipropamid and captan.Preferably, described mandipropamid and captan are combined as the form of the composition that comprises mandipropamid and captan.
A kind of bactericidal composition that contains mandipropamid and captan of the present invention and uses thereof, mandipropamid and captan is composite, has synergistic function, not only can prevent and treat the germ harm of cereal, fruit, vegetables, flowers, lawn, economic crops, can also doublely control the fungus and bacterium disease in the soil, it is multiplex to have a medicine, widens the diseases prevention spectrum.And be used for soil treatment or soak (mixing) kind, mashed kind, the mashed root that can prevent soil disease to cause ensure full stand, alleviate sprout term disease, better effects if.
Embodiment
Example of formulations
Embodiment 1 water dispersible granules
Mandipropamid 1%
Captan 50%
Polyvinyl alcohol 5%
Lauryl sodium sulfate 7%
Sodium lignin sulfonate 11%
Kaolin complements to 100%
Above-mentioned substance is evenly mixed, grinds, mixes suitable quantity of water and granulation, namely get said preparation after the drying.
Embodiment 2 wetting powders (gross weight of preparation is 100 parts)
Mandipropamid 50%
Captan 10%
Alkylnaphthalene sulfonate formaldehyde condensation products 5%
Sodium alkyl benzene sulfonate 3%
Sodium lignin sulfonate 11%
Kaolin complements to 100%
Active component, various auxiliary agent and filler etc. are fully mixed in the ratio of prescription, behind ultra-fine pulverizer disintegrating, namely get said preparation.
Embodiment 3 suspending agents (gross weight of preparation is 100 parts)
Mandipropamid 50%
Captan 1%
Propane diols 5%
Phosphoric acid ester 3.5%
Xanthans 0.2%
Dioctyl sodium sulfosuccinate 0.7%
Water complements to 100%
Take by weighing according to the above ratio and have the high microbicide compositions of synergistic effect and prepare material, load weighted above-mentioned raw material except xanthans is fully mixed, after sand mill grinds, mixing with a certain proportion of xanthans that configures, namely get said preparation.
Embodiment 4 wetting powders (gross weight of preparation is 100 parts)
Mandipropamid 0.5%
Captan 50%
Alkylnaphthalene sulfonate formaldehyde condensation products 5%
Alkyl polyoxyethylene ether sulfonate 4%
NONIN HS 240 3%
(8-9 moles of ethylene oxide)
Kaolin complements to 100%
Active component, various auxiliary agent and filler etc. are fully mixed in the ratio of prescription, behind ultra-fine pulverizer disintegrating, namely get said preparation.
Embodiment 5 water dispersible granules (gross weight of preparation is 100 parts)
Mandipropamid 20%
Captan 1%
Polyvinyl alcohol 5%
Lauryl sodium sulfate 7%
Sodium lignin sulfonate 11%
Kaolin complements to 100%
Above-mentioned substance is evenly mixed, grinds, mixes suitable quantity of water and granulation, namely get said preparation after the drying.
Embodiment 6 wetting powders (gross weight of preparation is 100 parts)
Mandipropamid 2%
Captan 40%
Alkylnaphthalene sulfonate formaldehyde condensation products 5%
Alkyl polyoxyethylene ether sulfonate 4%
NONIN HS 240 3%
(8-9 moles of ethylene oxide)
Kaolin complements to 100%
Active component, various auxiliary agent and filler etc. are fully mixed in the ratio of prescription, behind ultra-fine pulverizer disintegrating, namely get said preparation.
Embodiment 7 wetting powders (gross weight of preparation is 100 parts)
Mandipropamid 20%
Captan 40%
Alkylnaphthalene sulfonate formaldehyde condensation products 5%
Alkyl polyoxyethylene ether sulfonate 4%
NONIN HS 240 3%
(8-9 moles of ethylene oxide)
Kaolin complements to 100%
Active component, various auxiliary agent and filler etc. are fully mixed in the ratio of prescription, behind ultra-fine pulverizer disintegrating, namely get said preparation.
Embodiment 8 water dispersible granules (gross weight of preparation is 100 parts)
Mandipropamid 20%
Captan 10%
Polyvinyl alcohol 5%
Lauryl sodium sulfate 7%
Sodium lignin sulfonate 6%
Kaolin complements to 100%
Above-mentioned substance is evenly mixed, grinds, mixes suitable quantity of water and granulation, namely get said preparation after the drying.
9 kinds of clothing agent of embodiment (gross weight of preparation is 100 parts)
Mandipropamid 5%
Captan 50%
Propane diols 5%
Phosphoric acid ester 3.5%
Xanthans 0.2%
Dioctyl sodium sulfosuccinate 0.7%
Water complements to 100%
Take by weighing according to the above ratio and have the high microbicide compositions of synergistic effect and prepare material, load weighted above-mentioned raw material except xanthans is fully mixed, after sand mill grinds, mixing with a certain proportion of xanthans that configures, namely get said preparation.
Embodiment 10 aerosols (gross weight of preparation is 100 parts)
Mandipropamid 50%
Captan 5%
Propane diols 5%
Phosphoric acid ester 3.5%
The castor oil of ethoxylation (EL-40) 2.0%
Solvesso 100 complements to 100%
At first with the antifreezing agent propane diols, thinner SOLVESSO 100 mixes, and stirs lower add mandipropamid and captan; Surfactant is added wherein, under agitation pulverize by a breaking plant colloid mill, will be by the suspension behind the colloid mill, again through a micronizer.Move in circles till the particle diameter≤2um of solids.
Embodiment 11 ZC
Atlox 4913 4%
Citric acid 0.05%
Catalyzer 0.1%
Water 13%
Mandipropamid 10%
PAPI 1.35%
Solvesso 200 10%
Atlox4913 16%
Dispersant LFH 0.3%
Defoamer 0.16%
Urea 8.4%
Captan 50%
Water complements to 100%
With PAPI, the oil phase that captan and Solvesso 100 form adds and contains in the aqueous solution of Atlox4913, forms emulsion.Then heat and be incubated 50
oAdded catalyst reaction 2 hours under the C.Obtain the microcapsules of captan after the cooling.Atlox 4913, dispersant LFH, and defoamer, urea, mandipropamid and water mix in proportion, and through sand milling, are prepared into suspending agent.The microcapsules of the captan that obtains is added in the aqueous suspension agent of mandipropamid, and stirring obtains 10% mandipropamid+50% captan ZC.
Embodiment 12 extrudes granule
Mandipropamid 45%
Captan 45%
Sodium lignin sulfonate 4%
Carboxymethyl cellulose 2%
Kaolin complements to 100%
Active component is mixed with auxiliary agent and grind the mixture water-wet.This mixture is extruded, then dry in air stream.
Embodiment 13 coated granules
Mandipropamid 20%
Captan 60%
Polyethylene glycol 3%
The silicic acid 1% of high degree of dispersion
Calcium carbonate complements to 100%
In blender, levigate active component evenly is applied to by on the wetting carrier of polyethylene glycol.Can obtain dustless coated granule in this way.
Embodiment 14 missible oil
Mandipropamid 50%
Captan 0.5%
Ethoxylated castor oil 10%
Calcium dodecyl benzene sulfonate 6%
Solvesso 100 complements to 100%
With active ingredient, auxiliary agent and stirring solvent to transparent and homogeneous mutually, namely obtain missible oil.
Embodiment 15 effervescent tablets
Mandipropamid 1%
Captan 4%
Polyvinyl alcohol 2.0 %
Sodium Laurylsulfate 4.0%
Calcium carbonate 5.0%
White carbon complements to 100%
Above-mentioned substance is evenly mixed, grinds, mixes suitable quantity of water and granulation, namely get said preparation after the drying.
Embodiment 16 pastes
Mandipropamid 5%
Captan 5%
Lignosulfonates 10.0%
Octyl phenol polyglycol ether (11-14 moles of ethylene oxide) 5.0%
Water complements to 100%
Above-mentioned substance is mixed to homogeneous phase, namely obtain paste.
Embodiment 17 microemulsions
Mandipropamid 20.0 %
Captan 20.0%
Polyvinyl alcohol 10.0 %
Calcium dodecyl benzene sulfonate 5.0%
Water complements to 100%
Obtain the solution of clear after above-mentioned substance stirred.
Embodiment 18 aqueous emulsions
Mandipropamid 15%
Captan 5.0 %
1-METHYLPYRROLIDONE 15.0%
Ethoxylated castor oil 4.0%
Calcium dodecyl benzene sulfonate 3.0%
Water complements to 100%
Mandipropamid, captan are dissolved in the 1-METHYLPYRROLIDONE fully, add in the solution of ethoxylated castor oil, calcium dodecyl benzene sulfonate, obtain aqueous emulsion after the high shear.
Above embodiment proportioning is the weight per distribution ratio.
The biological test example
Calculate the toxicity index of each medicament and the co-toxicity coefficient of mixture (CTC value) according to the abundant method of Sun Yun, when CTC≤80, then compositions table reveals antagonism, when 80＜CTC＜120, then compositions table reveals summation action, and when CTC 〉=120, then compositions table reveals synergistic effect.
Actual measurement toxicity index (ATI)=(standard medicament EC50/ reagent agent EC50) * 100
The percentage composition of B in the percentage composition of A+B medicament toxicity index * mixture in theoretical toxicity index (TTI)=A medicament toxicity index * mixture
Co-toxicity coefficient (CTC)=[mixture actual measurement toxicity index (ATI)/theoretical toxicity index (TTI) * 100 of mixture
Test one: the toxicity test of potato cinerea
Be selected from the consistent potato set of growing way, each processing selects 3 basins for examination leaf seedling, and in the spraying of 50PSI pressure column, the about 5mL of every basin, each medicament arrange 12 concentration gradients with the potter spray tower.24h connects bacterium after the chemicals treatment, the potato cinerea leaf that picks up from the field is evenly shaken off conidium inoculate above potato set, then potato set is put into the greenhouse and cultivates.Morbidity grade scale complete stool according to potato cinerea behind the 7d is investigated disease index, and calculates control efficiency, then calculates concentration EC in the inhibition with method of least squares
50, calculate co-toxicity coefficient (CTC) according to the abundant method of Sun Yun again.
Table one: the virulence test result of the present invention on the control potato cinerea
From table one as can be known, mandipropamid and captan are in the scope of the proportioning 1:100 ~ 100:1 of control potato cinerea the time, co-toxicity coefficient is all greater than 120, illustrate that both all show as gain effect at being mixed in this scope, especially when both ratio was in 1:5, gain effect was particularly outstanding.
Test two: the toxicity test of downy mildew of garpe
Select the consistent grapevine seedling of growing way, in the spraying of 50PSI pressure column, the about 5mL of every basin, each medicament arrange 12 concentration gradients with the potter spray tower.24h connects bacterium after the chemicals treatment, the downy mildew of garpe leaf is evenly shaken off conidium inoculate above grapevine seedling, then grapevine seedling is put into the greenhouse and cultivates.Morbidity grade scale complete stool according to downy mildew of garpe behind the 7d is investigated disease index, and calculates control efficiency, then calculates concentration EC in the inhibition with method of least squares
50, calculate co-toxicity coefficient (CTC) according to the abundant method of Sun Yun again.
Table two: the present invention is in the virulence test result of preventing and treating on the downy mildew of garpe
From table two as can be known, mandipropamid and captan are in the scope of preventing and treating the proportioning 1:100 of downy mildew of garpe ~ 100:1 the time, co-toxicity coefficient is all greater than 120, illustrate that both all show as gain effect at being mixed in this scope, especially when both ratio was in 1:5, gain effect was particularly outstanding.
Test three: the toxicity test of angular leaf spot
Be selected from the consistent cucumber young phase leaf seedling of growing way, each processing selects 3 basins for examination leaf seedling, and in the spraying of 50PSI pressure column, the about 5mL of every basin, each medicament arrange 12 concentration gradients with the potter spray tower.24h connects bacterium after the chemicals treatment, the angular leaf spot leaf that picks up from the field is evenly shaken off conidium inoculate above cucumber seedling, then the cucumber leaf seedling is put into the greenhouse and cultivates.Morbidity grade scale complete stool according to angular leaf spot behind the 7d is investigated disease index, and calculates control efficiency, then calculates concentration EC in the inhibition with method of least squares
50, calculate co-toxicity coefficient (CTC) according to the abundant method of Sun Yun again.
Table three: the virulence test result of the present invention on the control angular leaf spot
From table three as can be known, mandipropamid and captan are in the scope of the proportioning 1:100 ~ 100:1 of control angular leaf spot the time, co-toxicity coefficient is all greater than 120, illustrate that both all show as gain effect at being mixed in this scope, especially when both ratio was in 1:1, gain effect was particularly outstanding.
Test four: the toxicity test of capsicum epidemic disease
Be selected from the consistent Seedling Stage capsicum leaf seedling of growing way, each processing selects 3 basins for examination leaf seedling, and in the spraying of 50PSI pressure column, the about 5mL of every basin, each medicament arrange 12 concentration gradients with the potter spray tower.24h connects bacterium after the chemicals treatment, the capsicum epidemic disease leaf that picks up from the field is evenly shaken off conidium inoculate above Hot Pepper Seedling, then capsicum leaf seedling is put into the greenhouse and cultivates.Morbidity grade scale complete stool according to capsicum epidemic disease behind the 7d is investigated disease index, and calculates control efficiency, then calculates concentration EC in the inhibition with method of least squares
50, calculate co-toxicity coefficient (CTC) according to the abundant method of Sun Yun again.
Table four: the virulence test result of the present invention on the control capsicum epidemic disease
From table four as can be known, mandipropamid and captan are in the scope of the proportioning 1:100 ~ 100:1 of control capsicum epidemic disease the time, co-toxicity coefficient is all greater than 120, illustrate that both all show as gain effect at being mixed in this scope, especially when both ratio was in 1:10, gain effect was particularly outstanding.
Test 5
When the effect of active compound combinations surpasses the summation of the effect when each reactive compound is used separately, there is synergistic function.The predictive role of the particular combinations of two kinds of reactive compounds can use so-called " Colby formula " (referring to S.R. Colby, " Calculating Synergistic and Antagonistic Responses of Herbicide Combinations ", Weeds 1967,15,20-22) following calculating: if
X be when use consumption as mg/ha or concentration the activity during as the reactive compound A of mppm;
Y be when use consumption as ng/ha or concentration the activity during as the reactive compound B of nppm, be expressed as the percentage that accounts for untreated control;
E be when use consumption as m and n g/ha or concentration the activity during as the reactive compound A of m and n ppm and B,
So
If the activity of actual observation (O) is greater than expection active (E), said composition [l1] namely has synergistic effect so.
Following biological test example is in order to illustrate the present invention.But the present invention is not limited to these embodiment.
Prolection to downy mildew of garpe
The leaf of potted plant grapevine seedling is sprayed with the aqueous suspension of the activity compound concentration with above appointment.Second day is with the spore suspension of the plant inoculating downy mildew of garpe of processing.Then basin is placed on 20-22
oIn the chamber with high atmospheric humidity (90-95%) under the C 24 hours.During this period, spore-germination and germ tube infiltrate in the leaf texture.Second day is back to test plants in the greenhouse and cultivated under the relative atmospheric humidity with 65-70% of 20-220C other 7 days.Then estimate the degree of downy mildew development on the leaf.
Claims (15)
1. a bactericidal composition that contains mandipropamid and captan is characterized in that: contain active component mandipropamid and captan.
2. a kind of bactericidal composition that contains mandipropamid and captan according to claim 1, it is characterized in that: described active component mandipropamid and captan weight proportion are 1:100-100:1.
3. a kind of bactericidal composition that contains mandipropamid and captan according to claim 1, it is characterized in that: the weight proportion of described active component mandipropamid and captan is: 1:50-50:1.
4. a kind of bactericidal composition that contains mandipropamid and captan according to claim 1, it is characterized in that: the weight proportion of described active component mandipropamid and captan is: 1:20-20:1.
5. a kind of bactericidal composition that contains mandipropamid and captan according to claim 1, it is characterized in that: the weight proportion of described active component mandipropamid and captan is: 1:10-10:1.
6. a kind of bactericidal composition that contains mandipropamid and captan according to claim 1, it is characterized in that: the weight proportion of described active component mandipropamid and captan is: 1:5-5:1.
7. a kind of bactericidal composition that contains mandipropamid and captan according to claim 1, it is characterized in that: the weight percentage that described active component mandipropamid and captan account for described composition is 5%-90%.
8. a kind of bactericidal composition that contains mandipropamid and captan according to claim 1, it is characterized in that: the weight percentage that described active component mandipropamid and captan account for described composition is 10%-80%.
9. a kind of bactericidal composition that contains mandipropamid and captan according to claim 1, it is characterized in that: the weight percentage that described active component mandipropamid and captan account for described composition is 20%-60%.
10. a kind of bactericidal composition that contains mandipropamid and captan according to claim 1, it is characterized in that: described active component mandipropamid and captan mix with liquid or solid carrier and/or surfactant.
11. a kind of bactericidal composition that contains mandipropamid and captan according to claim 1 is characterized in that: the formulation of described bactericidal composition is suspending agent, plants clothing agent, wetting powder, water dispersible granules, micro-capsule granules, paste, aerosol, ZC, coated granule, extrudes granule, missible oil, microemulsion, aqueous emulsion, effervescent tablet.
12. according to each a kind of bactericidal composition that contains mandipropamid and captan in the aforementioned claim, it is characterized in that: also comprise one or more other active components.
13. a kind of bactericidal composition of mandipropamid and captan that contains according to claim 1 is for the purposes of the germ harm that prevents and treats cereal, fruit, vegetables, flowers, lawn, economic crops.
14. a kind of bactericidal composition that contains mandipropamid and captan according to claim 1 is for the protection of the purposes of plant propagation material and the plant organ that grows subsequently.
15. described a kind of bactericidal composition that contains mandipropamid and captan place control soil of being applied to required control causes a disease or the purposes of saprophytic fungus and bacterium according to claim 1.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107897197A (en) * | 2017-12-26 | 2018-04-13 | 广东广康生化科技股份有限公司 | A kind of microbicide compositions containing folpet and mandipropamid |
| CN107980791A (en) * | 2017-12-14 | 2018-05-04 | 广东广康生化科技股份有限公司 | Containing captan He the bactericidal composition of famoxadone and its application |
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| CN1336912A (en) * | 1999-01-11 | 2002-02-20 | 辛根塔参与股份公司 | Novel propargylether derivatives |
| CN1429198A (en) * | 2000-05-17 | 2003-07-09 | 辛根塔参与股份公司 | Novel phenyl-proparylether derivatives |
| CN101198254A (en) * | 2005-06-21 | 2008-06-11 | 拜尔农科股份有限公司 | Fungicide composition comprising a phosphorous acid derivative, a mandelamide type compound and a further fungicide compound |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1336912A (en) * | 1999-01-11 | 2002-02-20 | 辛根塔参与股份公司 | Novel propargylether derivatives |
| CN1429198A (en) * | 2000-05-17 | 2003-07-09 | 辛根塔参与股份公司 | Novel phenyl-proparylether derivatives |
| CN101198254A (en) * | 2005-06-21 | 2008-06-11 | 拜尔农科股份有限公司 | Fungicide composition comprising a phosphorous acid derivative, a mandelamide type compound and a further fungicide compound |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107980791A (en) * | 2017-12-14 | 2018-05-04 | 广东广康生化科技股份有限公司 | Containing captan He the bactericidal composition of famoxadone and its application |
| CN107897197A (en) * | 2017-12-26 | 2018-04-13 | 广东广康生化科技股份有限公司 | A kind of microbicide compositions containing folpet and mandipropamid |
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