CN103347553B - 具有弹簧元件的药物递送装置 - Google Patents

具有弹簧元件的药物递送装置 Download PDF

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Publication number
CN103347553B
CN103347553B CN201180066267.5A CN201180066267A CN103347553B CN 103347553 B CN103347553 B CN 103347553B CN 201180066267 A CN201180066267 A CN 201180066267A CN 103347553 B CN103347553 B CN 103347553B
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CN
China
Prior art keywords
dose
dose setting
setting mechanism
medicament
drug delivery
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201180066267.5A
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English (en)
Chinese (zh)
Other versions
CN103347553A (zh
Inventor
D.M.利克
M.S.波伊德
D.T.德索斯马里兹林特尔
S.L.比尔顿
D.D.希金斯
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Sanofi Aventis Deutschland GmbH
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Sanofi Aventis Deutschland GmbH
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Publication of CN103347553A publication Critical patent/CN103347553A/zh
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Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests
    • A61M5/178—Syringes
    • A61M5/19—Syringes having more than one chamber
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31525—Dosing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/3155—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
    • A61M5/31551—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe including axial movement of dose setting member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/3156—Mechanically operated dose setting member using volume steps only adjustable in discrete intervals, i.e. individually distinct intervals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/31561—Mechanically operated dose setting member using freely adjustable volume steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31576—Constructional features; Drive mechanisms or modes for piston rods
    • A61M5/31583—Constructional features; Drive mechanisms or modes for piston rods the piston rod being moved by the rotational movement of a component directly in contact with it
    • A61M5/31585—Constructional features; Drive mechanisms or modes for piston rods the piston rod being moved by the rotational movement of a component directly in contact with it the component being manually operated or triggered by an axially moving actuator operated by user, e.g. an axially movable injection button
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/006—Sprayers or atomisers specially adapted for therapeutic purposes operated by applying mechanical pressure to the liquid to be sprayed or atomised
    • A61M11/007—Syringe-type or piston-type sprayers or atomisers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A61M15/0033—Details of the piercing or cutting means
    • A61M15/0035—Piercing means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M2005/2006—Having specific accessories
    • A61M2005/202—Having specific accessories cocking means, e.g. to bias the main drive spring of an injector
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or cartridges, e.g. automatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31566—Means improving security or handling thereof
    • A61M5/3157—Means providing feedback signals when administration is completed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/3159—Dose expelling manners
    • A61M5/31593—Multi-dose, i.e. individually set dose repeatedly administered from the same medicament reservoir

Landscapes

  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
CN201180066267.5A 2010-11-29 2011-11-28 具有弹簧元件的药物递送装置 Expired - Fee Related CN103347553B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP10192835.6 2010-11-29
EP10192835 2010-11-29
US201161433683P 2011-01-18 2011-01-18
US61/433,683 2011-01-18
PCT/EP2011/071117 WO2012072541A1 (en) 2010-11-29 2011-11-28 Drug delivery device having a spring element

Publications (2)

Publication Number Publication Date
CN103347553A CN103347553A (zh) 2013-10-09
CN103347553B true CN103347553B (zh) 2015-08-26

Family

ID=44021790

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201180066267.5A Expired - Fee Related CN103347553B (zh) 2010-11-29 2011-11-28 具有弹簧元件的药物递送装置

Country Status (6)

Country Link
US (1) US9402961B2 (enExample)
EP (1) EP2646076B1 (enExample)
JP (1) JP5916749B2 (enExample)
CN (1) CN103347553B (enExample)
DK (1) DK2646076T3 (enExample)
WO (1) WO2012072541A1 (enExample)

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GB2497375A (en) * 2012-06-29 2013-06-12 Sanofi Aventis Deutschland Multiple medicament delivery system
EP3021908A1 (en) * 2013-07-17 2016-05-25 Sanofi Drive mechanism for a drug delivery device
CA2920835A1 (en) 2013-08-20 2015-02-26 Anutra Medical, Inc. Syringe fill system and method
WO2015074979A2 (en) * 2013-11-22 2015-05-28 Sanofi-Aventis Deutschland Gmbh Spring assisted drug delivery device
WO2015106107A1 (en) 2014-01-10 2015-07-16 Bayer Medical Care Inc. Single-use disposable set connector
WO2015181191A1 (en) * 2014-05-28 2015-12-03 Sanofi-Aventis Deutschland Gmbh Housing for a drug delivery device and drug delivery device
JP6622223B2 (ja) * 2014-05-28 2019-12-18 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 薬物送達デバイス用の用量設定機構、および薬物送達デバイス
USD763433S1 (en) * 2014-06-06 2016-08-09 Anutra Medical, Inc. Delivery system cassette
USD774182S1 (en) 2014-06-06 2016-12-13 Anutra Medical, Inc. Anesthetic delivery device
ES3030489T3 (en) 2015-01-09 2025-06-30 Bayer Healthcare Llc Multiple fluid delivery system with multi-use disposable set and features thereof
US10661014B2 (en) 2015-01-21 2020-05-26 Antares Pharma, Inc. Injection device having variable dosing
US20170100738A1 (en) * 2015-10-13 2017-04-13 The Werc Shop, LLC Metered Dosing Method and Mechanisms Thereof
US20180161510A1 (en) * 2015-05-27 2018-06-14 Sanofi-Aventis Deutschland Gmbh Drug delivery device
CN108025138A (zh) * 2015-10-01 2018-05-11 诺和诺德股份有限公司 在自动药物递送装置中的扭力弹簧固定
CN108472448B (zh) * 2015-12-30 2022-04-19 诺和诺德股份有限公司 用于序贯剂量递送的机构
WO2017205824A1 (en) 2016-05-27 2017-11-30 Proveris Scientific Corporation Devices and methods for using medicament devices
TWI746569B (zh) 2016-06-08 2021-11-21 瑞士商瑞健醫療股份有限公司 計量器具、注射裝置、及其應用
TWI651107B (zh) * 2016-06-15 2019-02-21 拜耳保健公司 多次使用可棄式系統及用於該系統之注射器
WO2018096149A1 (de) 2016-11-28 2018-05-31 Idorsia Pharmaceuticals Ltd Vorrichtung zur abgabe einer substanz
WO2019110559A1 (en) 2017-12-04 2019-06-13 Novo Nordisk A/S Spring straining mechanism for torsion spring based device
CN111989486B (zh) * 2018-04-19 2022-07-19 贝克顿·迪金森公司 自动泵送注射器
US10947105B2 (en) * 2018-11-22 2021-03-16 Maksim Nilov Hand held, volumetric multi material dispenser
KR102640172B1 (ko) 2019-07-03 2024-02-23 삼성전자주식회사 기판 처리 장치 및 이의 구동 방법
DE102019123730A1 (de) * 2019-09-04 2021-03-04 Henke-Sass, Wolf Gmbh Vorrichtung zum Applizieren eines Fluids
DE102019123734A1 (de) * 2019-09-04 2021-03-04 Henke-Sass, Wolf Gmbh Vorrichtung zum Applizieren eines Fluids
DE102019123733A1 (de) 2019-09-04 2021-03-04 Henke-Sass, Wolf Gmbh Vorrichtung zum Applizieren eines Fluids
DE102019123731A1 (de) 2019-09-04 2021-03-04 Henke-Sass, Wolf Gmbh Vorrichtung zum Applizieren eines Fluids
DE102019123735A1 (de) 2019-09-04 2021-03-04 Henke-Sass, Wolf Gmbh Vorrichtung zum Applizieren eines Fluids
DE102020119751A1 (de) 2020-07-27 2022-01-27 Henke-Sass, Wolf Gmbh Vorrichtung zum Applizieren eines Fluids
CN113576551B (zh) * 2021-07-21 2024-05-07 湖北汽车工业学院 一种肠道用螺旋式定点操作机构
US20240181442A1 (en) * 2022-08-23 2024-06-06 Maksim Nilov Parametric Multi Component Dispenser

Citations (5)

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US5378233A (en) * 1992-11-18 1995-01-03 Habley Medical Technology Corporation Selected dose pharmaceutical dispenser
US5423752A (en) * 1992-07-31 1995-06-13 Habley Medical Technology Corporation Variable proportion dispenser with cartridge replacement assembly
US20070060894A1 (en) * 2003-05-30 2007-03-15 He Dai Multiple chamber medication dispensing apparatus
WO2010077279A1 (en) * 2008-12-09 2010-07-08 Becton, Dickinson And Company Multi-stroke delivery pumping mechanism for a drug delivery device for high pressure injections
WO2010077280A1 (en) * 2008-12-09 2010-07-08 Becton, Dickinson And Company Open and closed valve medication delivery system for high pressure injections

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US5271527A (en) 1992-04-02 1993-12-21 Habley Medical Technology Corporation Reusable pharmaceutical dispenser with full stroke indicator
ZA941881B (en) * 1993-04-02 1995-09-18 Lilly Co Eli Manifold medication injection apparatus and method
TW201109056A (en) * 2009-06-02 2011-03-16 Sanofi Aventis Deutschland Delivery of two or more medicaments through a single dose selection and single dispense interface
US9089645B2 (en) * 2010-11-29 2015-07-28 Sanofi-Aventis Deutschland Gmbh Drug delivery device
EP2646084A1 (en) * 2010-11-29 2013-10-09 Sanofi-Aventis Deutschland GmbH Drug delivery device having a collar and a linkage component
US9248239B2 (en) * 2010-11-29 2016-02-02 Sanofi-Aventis Deutschland Gmbh Drug delivery device having linked dose dial components
EP2646074A1 (en) * 2010-11-29 2013-10-09 Sanofi-Aventis Deutschland GmbH Drug delivery device having a trigger

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5423752A (en) * 1992-07-31 1995-06-13 Habley Medical Technology Corporation Variable proportion dispenser with cartridge replacement assembly
US5378233A (en) * 1992-11-18 1995-01-03 Habley Medical Technology Corporation Selected dose pharmaceutical dispenser
US20070060894A1 (en) * 2003-05-30 2007-03-15 He Dai Multiple chamber medication dispensing apparatus
WO2010077279A1 (en) * 2008-12-09 2010-07-08 Becton, Dickinson And Company Multi-stroke delivery pumping mechanism for a drug delivery device for high pressure injections
WO2010077280A1 (en) * 2008-12-09 2010-07-08 Becton, Dickinson And Company Open and closed valve medication delivery system for high pressure injections

Also Published As

Publication number Publication date
DK2646076T3 (da) 2014-10-27
US9402961B2 (en) 2016-08-02
JP2014501572A (ja) 2014-01-23
CN103347553A (zh) 2013-10-09
EP2646076A1 (en) 2013-10-09
US20130245565A1 (en) 2013-09-19
JP5916749B2 (ja) 2016-05-11
WO2012072541A1 (en) 2012-06-07
EP2646076B1 (en) 2014-07-30
HK1190347A1 (en) 2014-07-04

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