CN103340697A - Fixing device used for fixing back skin of experimental animal - Google Patents
Fixing device used for fixing back skin of experimental animal Download PDFInfo
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- CN103340697A CN103340697A CN2013103030019A CN201310303001A CN103340697A CN 103340697 A CN103340697 A CN 103340697A CN 2013103030019 A CN2013103030019 A CN 2013103030019A CN 201310303001 A CN201310303001 A CN 201310303001A CN 103340697 A CN103340697 A CN 103340697A
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Abstract
The invention relates to a fixing device used for fixing the back skin of an experimental animal. The fixing device used for fixing the back skin of the experimental animal comprises a base and fixing tables, wherein each fixing table comprises a connecting part and a fixing and clamping part connected with the connecting part, the fixing tables are connected with the base in a detachable mode through the connecting parts, the fixing and clamping parts of the two fixing tables are matched to form a fixing through hole allowing the experimental animal to pass through, and the end faces, away from the connecting parts, of the two fixing and clamping parts are matched to clamp the back skin of the experimental animal so that the back skin which is pulled up of the experimental animal can be spread on the outer walls of the fixing and clamping parts. The fixing device used for fixing the back skin of the experimental animal has the advantages that the back skin of the experimental animal can be fixed, negative influence of respiratory movement of the experimental animal on imaging is effectively avoided, damage to the experimental animal is small due to the fact the non-invasive fixing method is adopted, and long-time and stable observation and study of a subcutaneous transplantation tumor model on the back of the experimental animal by means of a photoacoustic imaging system is available.
Description
Technical field
The present invention relates to the photoacoustic imaging technical field, particularly relate to a kind of for the fixing fixture of laboratory animal skin of back.
Background technology
Photoacoustic imaging is a kind of novel noinvasive biomedical imaging technology that has optical imagery and ultra sonic imaging advantage concurrently.The principle of photoacoustic imaging is that pulse laser is incided in the biological tissue, tissue produces ultrasonic signal because transient heat expands, survey by ultrasonic probe and can obtain to react the signal that this place organizes light absorption information, thereby provide contrast mechanism based on optical absorption characteristics for imaging.And the hemoglobin in the biological tissue is to the degree of absorption difference of different wavelengths of light, and the strong and weak degree of the photoacoustic signal that is inspired is also different.Select the high single wavelength that absorbs that blood vessel is scanned, but direct imaging need not to inject any contrast medium; And select multi-wavelength to scan, and then can obtain parameters such as oxygen saturation, oxygen metabolism rate in the blood by calculating, this has great significance to research tumor-blood-vessel growth and research and development cancer therapy drug.
In the optoacoustic system of non-array, be subjected to the restriction of ultrasonic probe quantity and mechanical scanning speed, when it needs the long period during to big regional imaging, therefore require testee to keep resting state in scan period as far as possible.Because mice ear rich blood vessel, being easy to stationary fixing and being subjected to respirometricly influences lessly, and the main tumour transplatation during therefore current optoacoustic research tumor-blood-vessel growth and the position of observation are ear.Yet in the research of oncological pathology, than the tumor of ear model, Subcutaneous tumor model in back is accepted more widely.Still remain to be improved for mouse back Subcutaneous tumor imaging effect when yet current optoacoustic is studied tumor-blood-vessel growth, its main cause is the whole undulatory motion of its trunk of mouse breathing motion effects, and the testee in the motion causes the pseudo-shadow of imaging easily.
In the existing experimental apparatus, the external mouse back skin window device of producing (dorsal skin flap chamber) is specifically designed to fixedly mouse back skin.This device must be with the foil of circular hole to clamp in the middle of two the pull-up of mouse back skin, passes mouse back skin with screw, makes foil and skin fix; Cut off a side skin as the observation area, be embedded between skin and the foil with coverslip again.This device is very big to mice damage, and careless manipulation causes its ischemia easily, infect and cause death, and this device must omnidistance install under super-clean environment, and technology is loaded down with trivial details, and very high to operating environment and operator's requirement, the model success rate is lower.Even the model success, but because the damage of skin large tracts of land, the mice time-to-live is shorter, is about most to be 2-3 month, is unfavorable for observing as steady in a long-term.
Summary of the invention
Based on this, be necessary to provide a kind of can noinvasive the fixing fixture of laboratory animal skin of back.
A kind of for the fixing fixture of laboratory animal skin of back, comprise base and two fixed stations, described fixed station comprises connecting portion and the fixed clamp portion that is connected with described connecting portion, described fixed station removably connects by described connecting portion and described base, the fixed clamp portion of two described fixed stations cooperates and is formed for fixed via that laboratory animal is passed, and two described fixed clamp portions cooperate the skin of back that is used for the clamping laboratory animal away from the end face of described connecting portion, so that the skin of back that laboratory animal is pulled up is layed on the outer wall of described fixed clamp portion.
Among embodiment, described fixed via is the semicolumn bodily form therein.
Therein among embodiment, described fixed clamp portion is planar structure away from the outer wall of an end of described connecting portion, is layed on the described planar structure so that the skin of back that laboratory animal is pulled up is plane.
Among embodiment, described fixed via is square therein.
Therein among embodiment, described fixed clamp portion is away from fixedly being useful on the elastomeric pad that prevents from crushing the laboratory animal skin of back on the end face of described connecting portion.
Therein among embodiment, described fixed clamp portion is provided with groove away from the end face of described connecting portion, described elastomeric pad is provided with the fin with described groove fit, and described elastomeric pad is fixed on the end face of described fixed clamp portion away from described connecting portion by described fin.
Among embodiment, described base is provided with boss therein, and the close side of the connecting portion of described fixed station and described base is provided with the chute that cooperates with described boss, described fixed station by described chute on described base slidably.
Among embodiment, described base is provided with a plurality of screwed holes therein, and described screwed hole is distributed in the both sides of described boss; The connecting portion of described fixed station offers the connecting through hole that runs through described connecting portion on the position corresponding with described screwed hole, and the connecting portion of described fixed station removably connects by screw or bolt and described base.
Therein among embodiment, described boss is provided be used to making described base be installed on counterbore on the external device.
Therein among embodiment, described base over against the position of described fixed via in the length on the direction of two openings of described fixed via less than the distance between two openings of described fixed via.
Above-mentionedly can realize fixing to the laboratory animal skin of back for the fixing fixture of laboratory animal skin of back, thereby efficiently solve the adverse effect that the laboratory animal respiratory movement brings imaging, and said fixing is that noinvasive is fixed, little to the laboratory animal infringement, thus make that using photoacoustic imaging system has feasibility at the observational study that laboratory animal back subcutaneous transplantation tumor model carries out long-term stability.And the said fixing process need not carry out under super-clean environment, to operating environment and operator's operant level require relatively lowly, technology is simple, realizes easily.
Description of drawings
Fig. 1 is the fixedly structural representation of the fixture of laboratory animal skin of back that is used for of an embodiment;
Fig. 2 is the fixedly explosive view of the fixture of laboratory animal skin of back that is used among Fig. 1;
Fig. 3 is the fixedly structural representation of the fixture of laboratory animal skin of back that is used for of another embodiment;
Fig. 4 is the fixedly structural representation of the fixed station of the fixture of laboratory animal skin of back that is used among Fig. 1;
Fig. 5 is the fixedly structural representation of the base of the fixture of laboratory animal skin of back that is used among Fig. 1;
Fig. 6 is the fixedly structural representation of the elastomeric pad of the fixture of laboratory animal skin of back that is used among Fig. 1;
Fig. 7 is the fixedly working state schematic representation of the fixture of laboratory animal skin of back that is used among Fig. 1.
The specific embodiment
For the ease of understanding the present invention, with reference to relevant drawings the present invention is described more fully below.Provided preferred embodiment of the present invention in the accompanying drawing.But the present invention can realize with many different forms, be not limited to embodiment described herein.On the contrary, provide the purpose of these embodiment be make the understanding of disclosure of the present invention comprehensively thorough more.
Need to prove that when element is called as " being fixed in " another element, can directly can there be element placed in the middle in it on another element or also.When an element is considered to " connection " another element, it can be to be directly connected to another element or may to have element placed in the middle simultaneously.
Unless otherwise defined, the employed all technology of this paper are identical with the implication that belongs to those skilled in the art's common sense of the present invention with scientific terminology.Employed term is not intended to be restriction the present invention just in order to describe the purpose of specific embodiment in description of the present invention herein.Term as used herein " and/or " comprise one or more relevant Listed Items arbitrarily with all combinations.
As shown in Figures 1 and 2, an embodiment is used for fixedly that the fixture 10 of laboratory animal skin of back comprises fixed station 100, base 200, screw 300 and elastomeric pad 400.
In the present embodiment, laboratory animal is mice.Be appreciated that in other embodiments laboratory animal also can be rabbit, Cavia porcellus isotype biology.
As shown in Figures 2 and 3, fixed station 100 comprises connecting portion 110 and fixed clamp portion 120.Fixed clamp portion 120 is connected with connecting portion 110.In the present embodiment, connecting portion 110 is one-body molded with fixed clamp portion 120.
Fixed station 100 removably connects by connecting portion 110 and base 200.The fixed clamp portion 120 of two fixed stations 100 cooperates and is formed for fixed via 130 that mice is passed, and two fixed clamp portions 120 cooperate away from the end face 122 of connecting portion 110 and are used for clamping mouse back skin, so that the skin of back that mice is pulled up is layed on the outer wall 124 of fixed clamp portion.
In the present embodiment, fixed via 130 is roughly the semicolumn bodily form.When mice passed the fixed via 130 of the semicolumn bodily form, the skin of back that mice is pulled up was clamped in the top of fixed via 130, and the sidewall of the fixed via 130 of the semicolumn bodily form also can play certain fixed effect to mice.
When the skin of back to mice carries out photoacoustic imaging, because that ultrasound wave decay is very big, in order to survey the ultrasonic signal of generation, at the skin of back of mice and between popping one's head in couplant (being generally water or medical ultrasonic coupling agent) must be arranged in air.Usually ultrasonic probe is placed tank, perforate and layer overlay optical thin film under the tank are coated with the skin of back surface of mice and are close on the optical thin film after spreading couplant.When pulse laser import to inspire ultrasound wave in the biological tissue after, ultrasonic signal spreads out of from tissue, through couplant, thin film and water, is received by ultrasonic probe at last.For the skin of back that mice is pulled up is on the plane outer wall 124 that is layed in fixed clamp portion 120, fixed clamp portion 120 is made as planar structure 126 away from the part outer wall 124 of an end of connecting portion 110, is close to thereby be convenient to skin of back and optical thin film that mice is pulled up.
As shown in Figure 4, in other embodiments, fixed via 330 also can be for square, is convenient to skin of back and optical thin film that mice is pulled up and is close to.Be appreciated that fixed via also can be for other shapes, as isosceles trapezoid.
As Fig. 2, Fig. 3 and shown in Figure 5, in the present embodiment, base 200 is provided with boss 210.The connecting portion 110 of fixed station 100 and base 200 close sides are provided with the chute 112 that cooperates with boss 210.Fixed station 100 by chute 112 on base 200 slidably, in order to adjust fixed station 100 position on base 200, make two fixed station 100 rapid alignments, so can be fast fixing mouse back skin.
Be appreciated that, in other embodiments, can there be boss on the base yet, be that base can be slab construction, do not need to be provided with chute on the connecting portion of fixed station yet, at this moment, can adjust fixed station position on base yet, but in the alignment procedures of two fixed stations, the relatively slow situation of alignment speed may appear.
Further, base 200 is provided with a plurality of screwed holes 220, and screwed hole 220 is distributed in the both sides of boss 210.The connecting portion 110 of fixed station 100 and screwed hole 220 offer the connecting through hole 114 that runs through connecting portion 110 on the corresponding position.The connecting portion 110 of fixed station 100 is removably connected on the base 200 by screw 300.Further, connecting through hole 114 extends towards the end of connecting portion 110 away from fixed clamp portion 120, and runs through connecting portion 110 away from the end face of an end of fixed clamp portion 120, obtains having the link slot of three openings.
In the present embodiment, screw 300 comprises threaded post 310 and is located at the nut 320 of threaded post 310 1 ends.When the connecting portion 110 of fixed station 100 was connected on the base 200, threaded post 310 was passed connecting through hole 114, was connected with the screwed hole 220 of connecting through hole 114 belows, and nut 320 is positioned on the connecting through hole 114 near the surface of threaded post 310 1 sides.Screw 300 is preferably soket head cap screw.Be appreciated that in other embodiments, also can replace screw with bolt.
Because base 200 is provided with a plurality of screwed holes 220, and fixed station 100 by chute 112 on base 200 slidably, after fixing what a fixed station 100 at base 200, when fixing another fixed station 100, can suitably adjust another fixed station 100 position on base 200, so that two fixed stations 100 reach best mated condition.
Be appreciated that, in other embodiments, can at connecting portion connecting through hole be set yet, can offer screwed hole in the bottom of chute, screwed hole runs through chute, boss and base, makes the connecting portion of fixed station be removably connected on the base by screw again.
In addition, be appreciated that in other embodiments, also can adopt other fixed forms to replace herein screw and the screwed hole connecting portion of realizing fixed station to be removably connected on the base, as the mode of gluing knot.
When the skin of back to mice carries out photoacoustic imaging, need sometimes that the fixture 10 of mouse back skin is installed on external device with being used for fixedly, external device may be mechanical elevating platform or optical table.In the present embodiment, also be provided with counterbore 230 at boss 210.Base 200 is installed on the external device by screw 300 and counterbore 230.
When mice passed fixed via 130, state was that mouse back pastes mutually with fixed via 130 tops preferably.For mouse back and fixed via 130 tops are pasted mutually, in the present embodiment, base 200 over against the position of fixed via 130 in the length on the direction of two openings of fixed via 130 less than the distance between two openings of fixed via 130.When external force was pushed down mouse head, owing to there is difference in height, the back of mice can be corresponding to fixed via 130 tops.
As Fig. 2 and shown in Figure 6, further, in order to prevent that fixed clamp portion 120 from crushing mouse back skin away from the end face 122 of connecting portion 110, fixedly be useful on the elastomeric pad 400 that prevents from crushing mouse back skin in fixed clamp portion 120 away from the end face 122 of connecting portion 110.The material of elastomeric pad 400 is rubber.
In the present embodiment, fixed clamp portion 120 is provided with the groove (not shown) away from the end face 122 of connecting portion 110, and elastomeric pad 400 is provided with the fin 410 with groove fit.Elastomeric pad 400 is fixed on the end face 122 of fixed clamp portion 120 away from connecting portion 110 by fin 410.Elastomeric pad 400 is fixed in fixed clamp portion 120 away from the end face 122 of connecting portion 110 time, and the upper surface of elastomeric pad 400 and planar structure 126 be copline roughly.
Be appreciated that, in other embodiments, also can not have fin 410 on the elastomeric pad 400, namely elastomeric pad 400 can be laminated structure, can elastomeric pad 400 be fixed on the end face 122 of fixed clamp portion 120 away from connecting portion 110 by the mode of gluing knot.
As Fig. 2 and shown in Figure 7, during above-mentioned fixture 10 work for fixing mouse back skin, earlier fix a fixed station 100 at base 200, mice is positioned over (back of mice is away from base 200) on the base 200, place another fixed station 100 again, the fixed clamp portion 120 that makes mice be arranged in two fixed stations 100 cooperates the fixed via 130 that forms, and makes skin of back 20 that mice is pulled up simultaneously between the end face 122 of fixed clamp portion 120 away from connecting portion 110 of two fixed stations 100.Before base 200 is fixed another fixed station 100, suitably adjust fixed station 100 position on base 200 earlier, the skin of back 20 that makes mice be pulled up is clamped by two end faces 122, and the skin of back 20 that makes mice be pulled up is layed on the planar structure 126 of fixed clamp portion 120.
Above-mentionedly can realize fixing to mouse back skin for the fixing fixture 10 of mouse back skin, thereby efficiently solve the adverse effect that the mouse breathing motion brings imaging, and said fixing is that noinvasive is fixed, little to the mice infringement, thus make that using photoacoustic imaging system has feasibility at the observational study that mouse back subcutaneous transplantation tumor model carries out long-term stability.And the said fixing process need not carry out under super-clean environment, to operating environment and operator's operant level require relatively lowly, technology is simple, realizes easily.
The above embodiment has only expressed several embodiment of the present invention, and it describes comparatively concrete and detailed, but can not therefore be interpreted as the restriction to claim of the present invention.Should be pointed out that for the person of ordinary skill of the art without departing from the inventive concept of the premise, can also make some distortion and improvement, these all belong to protection scope of the present invention.Therefore, the protection domain of patent of the present invention should be as the criterion with claims.
Claims (10)
1. one kind is used for the fixedly fixture of laboratory animal skin of back, it is characterized in that, comprise base and two fixed stations, described fixed station comprises connecting portion and the fixed clamp portion that is connected with described connecting portion, described fixed station removably connects by described connecting portion and described base, the fixed clamp portion of two described fixed stations cooperates and is formed for fixed via that laboratory animal is passed, and two described fixed clamp portions cooperate the skin of back that is used for the clamping laboratory animal away from the end face of described connecting portion, so that the skin of back that laboratory animal is pulled up is layed on the outer wall of described fixed clamp portion.
2. according to claim 1 for the fixing fixture of laboratory animal skin of back, it is characterized in that described fixed via is the semicolumn bodily form.
3. according to claim 2 for the fixing fixture of laboratory animal skin of back, it is characterized in that, described fixed clamp portion is planar structure away from the outer wall of an end of described connecting portion, is layed on the described planar structure so that the skin of back that laboratory animal is pulled up is plane.
4. according to claim 1 for the fixing fixture of laboratory animal skin of back, it is characterized in that described fixed via is square.
5. according to claim 1ly it is characterized in that for the fixing fixture of laboratory animal skin of back that described fixed clamp portion is away from fixedly being useful on the elastomeric pad that prevents from crushing the laboratory animal skin of back on the end face of described connecting portion.
6. according to claim 5 for the fixing fixture of laboratory animal skin of back, it is characterized in that, described fixed clamp portion is provided with groove away from the end face of described connecting portion, described elastomeric pad is provided with the fin with described groove fit, and described elastomeric pad is fixed on the end face of described fixed clamp portion away from described connecting portion by described fin.
7. according to claim 1 for the fixing fixture of laboratory animal skin of back, it is characterized in that, described base is provided with boss, the close side of the connecting portion of described fixed station and described base is provided with the chute that cooperates with described boss, described fixed station by described chute on described base slidably.
8. according to claim 7 for the fixing fixture of laboratory animal skin of back, it is characterized in that, described base is provided with a plurality of screwed holes, described screwed hole is distributed in the both sides of described boss, the connecting portion of described fixed station offers the connecting through hole that runs through described connecting portion on the position corresponding with described screwed hole, and the connecting portion of described fixed station removably connects by screw or bolt and described base.
9. describedly it is characterized in that for the fixing fixture of laboratory animal skin of back according to claim 7 or 8 that described boss is provided be used to making described base be installed on counterbore on the external device.
10. according to claim 1 for the fixing fixture of laboratory animal skin of back, it is characterized in that, described base over against the position of described fixed via in the length on the direction of two openings of described fixed via less than the distance between two openings of described fixed via.
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| CN201310303001.9A CN103340697B (en) | 2013-07-18 | 2013-07-18 | Fixing device used for fixing back skin of experimental animal |
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| CN201310303001.9A CN103340697B (en) | 2013-07-18 | 2013-07-18 | Fixing device used for fixing back skin of experimental animal |
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| CN104257438A (en) * | 2014-09-29 | 2015-01-07 | 嘉兴博康生物科技有限公司 | Animal injury fixing clamp |
| CN104274157A (en) * | 2014-09-24 | 2015-01-14 | 深圳先进技术研究院 | Fixing device and photoacoustic tomography system with same |
| CN106308966A (en) * | 2016-09-14 | 2017-01-11 | 天津开发区合普工贸有限公司 | High-voltage electric shock anesthesia protection rack device for small animals |
| CN106821532A (en) * | 2017-02-28 | 2017-06-13 | 上海市第六人民医院 | A kind of mouse ridge skin wing form frame |
| CN107802372A (en) * | 2017-10-19 | 2018-03-16 | 中国科学院深圳先进技术研究院 | A kind of animal eyeball fixing device for photoacoustic imaging system |
| CN108498205A (en) * | 2018-05-12 | 2018-09-07 | 曹艳茹 | A kind of medicine small white mouse vivisection experimental bench |
| KR102052482B1 (en) * | 2018-07-19 | 2019-12-05 | 박성걸 | Injection restrainer for intracerebroventricular of Small Animal |
| CN111134887A (en) * | 2019-12-25 | 2020-05-12 | 西安交通大学 | Mouse spine window positioner for blood flow microscopic imaging experiment |
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| CN104274157A (en) * | 2014-09-24 | 2015-01-14 | 深圳先进技术研究院 | Fixing device and photoacoustic tomography system with same |
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| CN114668547A (en) * | 2022-03-25 | 2022-06-28 | 黑龙江中医药大学 | Stomach lavage device for traditional Chinese medicine digestive internal medicine experimental rat and use method |
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